LOCUS       NZ_CP075971            26146 bp    DNA     linear   CON 27-NOV-2024
DEFINITION  Clostridium perfringens strain C269 plasmid pCPC269_1.
ACCESSION   NZ_CP075971
VERSION     NZ_CP075971.1
KEYWORDS    RefSeq.
SOURCE      Clostridium perfringens
  ORGANISM  Clostridium perfringens
            Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales;
            Clostridiaceae; Clostridium.
REFERENCE   1  (bases 1 to 70475)
  AUTHORS   Jaakkola,K., Lahti,P., Virtanen,K., Lindstrom,M. and Korkeala,H.
  TITLE     Comparative genome analysis and spore heat resistance assay reveal
            niche adaptation within Clostridium perfringens enterotoxin-carrying
            isolates
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 70475)
  AUTHORS   Korkeala,H. and Jaakkola,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2021) Department of Food Hygiene and Environmental
            Health, University of Helsinki, Agnes Sjoberginkatu 2, Helsinki
            000066, Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 104x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020138715.1-RS_2024_11_27
            Annotation Date                   :: 11/27/2024 04:03:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,042
            CDSs (total)                      :: 2,914
            Genes (coding)                    :: 2,876
            CDSs (with protein)               :: 2,876
            Genes (RNA)                       :: 128
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 94
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 12 of 38
            Pseudo Genes (incomplete)         :: 22 of 38
            Pseudo Genes (internal stop)      :: 10 of 38
            Pseudo Genes (multiple problems)  :: 5 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:22:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 43439
            Orig. end                         :: 69585
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP075971.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26146
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26146
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26146
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16146](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16146)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(433..446)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     misc_feature    complement(1018..1029)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.05"
                     /tool="antismash"
     gene            1391..1618
                     /locus_tag="KLF29_RS14790"
     CDS             1391..1618
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLF29_RS14790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_011428893.1"
                     /transl_table=11
                     /translation="MYSIMNGINVEVYNNGKKVRDNYAVSEDDSDYEKDYEIPDIILDV
                     FDEFTLFKGLNELKYAKIYYKSDSGEYKLF"
     gene            1685..2214
                     /locus_tag="KLF29_RS15275"
                     /old_locus_tag="KLF29_14745"
                     /pseudo=""
     CDS             1685..2214
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003459028.1"
                     /locus_tag="KLF29_RS15275"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14745"
                     /product="transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKKREQIYTFLIDFIKEKGYQPTVREIAHAVNLKSSSTVYKHLEM
                     LEKDGLIKLGKREQRGRKRSIHIIDLNKKIKKMYQKKLLKI"
     gene            2500..2625
                     /locus_tag="KLF29_RS15230"
     CDS             2500..2625
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLF29_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_011428895.1"
                     /transl_table=11
                     /translation="MRLSEEDKKCIKILYKNGLNVKEIEKLLTNNFSKDDIQKHI"
     gene            2791..3258
                     /locus_tag="KLF29_RS14800"
                     /old_locus_tag="KLF29_14755"
     CDS             2791..3258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003463356.1"
                     /locus_tag="KLF29_RS14800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14755"
                     /product="hypothetical protein"
                     /protein_id="WP_003470153.1"
                     /transl_table=11
                     /translation="MKTAQEVANELDLTRTEVYNLLRKKRFSPLVKKNGGQVAISNELF
                     ILLEEEIKSKRNNIKQQEDKLLAKKNTITDVKTEKSPDFNIIEVLQNQIKLKDNQITIL
                     NDVITNNLKRIKNLEEKNHEFIKLHEELNNLKLVIDSIQTKKKRKRLLGVF"
     misc_feature    3293..3306
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.66"
                     /tool="antismash"
     misc_feature    complement(3812..3827)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.27"
                     /tool="antismash"
     gene            4770..5444
                     /locus_tag="KLF29_RS14805"
                     /old_locus_tag="KLF29_14760"
     CDS             4770..5444
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470166.1"
                     /locus_tag="KLF29_RS14805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14760"
                     /product="response regulator transcription factor"
                     /protein_id="WP_003470166.1"
                     /transl_table=11
                     /translation="MSKLLVIDDDIDMLDLVRATLEKDGHQVDTEVDATTIQPSKCQQY
                     DLLLLDVMMPSENGFSLCSRIRSEVDCPILFLTAKAEDTALVQGFGLGADDYIKKPFSI
                     AELRARVNAHLRREVRQPTHTLSRSGVRFNMQEKMAIVGEDTIFFTKGEYAISEHLALH
                     IGQVFTKEQLYEAVFGFDADGDSSAIVEHIKNIRAKLKAYNLNPIETVWGVGYKWRKDK
                     IL"
     gene            5420..6751
                     /locus_tag="KLF29_RS14810"
                     /old_locus_tag="KLF29_14765"
     CDS             5420..6751
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470155.1"
                     /locus_tag="KLF29_RS14810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14765"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_003470155.1"
                     /transl_table=11
                     /translation="MAKRQNSISLSFVLLRFTIIMLGCMLSCFIIWLTTLQLLEKKDFI
                     YHGSVSNQQVEKMLAGKPLNFISPNNNFLAKYALFNKSGEILESNVEGKELEILTMYLK
                     ENINDIHSLRYTYQDESTIVIRWNYRREFINPTLRNILPPFEYLWWGTLGIAWILCLIF
                     NTLWLRYNLATKLKLFSQVSEKVASQELEFEIPHAGIREYDQALDAMEHMRKALYTSLS
                     LQWAAKQERESEIESLAHDLKTPLTLIGGNAELLLYEDLPDNTLKMVKTIISSNDRAKN
                     YVVSLLEASIGIDEEFEKIRLYDLLDKLYQNTMPIAENKKIYLQKKNKLDGIANIQEER
                     LLRALGNIVQNAIEHTNAGRNVYLEGKMINGGWQIIVRDEGPGFSKAALQHATKRLWRD
                     DTARAKSNHNGIGLWFALQVVKMHSGQIKLQNYDCGGLVTIEFK"
     gene            6993..7694
                     /locus_tag="KLF29_RS14815"
                     /old_locus_tag="KLF29_14770"
     CDS             6993..7694
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470164.1"
                     /locus_tag="KLF29_RS14815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14770"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding subunit"
                     /protein_id="WP_003470164.1"
                     /transl_table=11
                     /translation="MHEYILKTNSVSKKFKKTYAVKNLSISVRRNSVYGLLGPNGAGKS
                     TLLKMIAGIVRPTSGEILFNNHDWTRKDLLDIGSLIESPPLYENLTAFENLKVRAILLG
                     IPLKKCNEVLEKMDLMDTKNKKTSDFSLGMKQRLGIALALLNNPKLLILDEPTNGLDPF
                     GIEELRKMIRRLVDSGISIIISSHILSEIQQVADDIGIIYNGTLLYEDSVNASEDLEQL
                     FMDIIRKERQS"
     gene            7694..8455
                     /locus_tag="KLF29_RS14820"
                     /old_locus_tag="KLF29_14775"
     CDS             7694..8455
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470130.1"
                     /locus_tag="KLF29_RS14820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14775"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_003470130.1"
                     /transl_table=11
                     /translation="MLQSYLKAESLKFKHSLFRKLTILIPLALILIAMIFMFVGIGLGG
                     FSSSIVCNWSMPIASLSIMFLCHQVNKKEKKHKYRTLYSLPIDLKKIFISKTILIALNL
                     LVISLLLSFISIISELVLSGFSVAIVYIGHYILGYILLWFSLLWQIPLCLFLDQKVGFI
                     ASIILSLFLSAFGGLFFALTPLFWIFPYSWTARLMTTLFGVLPNGLLVESGSKYILSLG
                     QSSFLILISIFIVVAFTGLFSVWYGKQVYRK"
     gene            8452..9183
                     /locus_tag="KLF29_RS14825"
                     /old_locus_tag="KLF29_14780"
     CDS             8452..9183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470126.1"
                     /locus_tag="KLF29_RS14825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14780"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_003470126.1"
                     /transl_table=11
                     /translation="MIILREFSSNFIKLKRTSLLLLHLLTPIVITFLFLYYYTISGYHI
                     ITDVRVFFIILQMCYPIFIGISVSAFTQLERNINAIQNTLGLVESRISIYLGKLLFMLF
                     LSAINLILYELCFYIGTNLFLDMNIFSLNLYVGIFLIFLLSNLFIYSLHLSIAFRFGST
                     VSVLLGIAGTILAGYFQTDIGDKIWPIIPWECGIRFLENYLNFSNSPIIFGIASMIILT
                     SIILILSILWFNRWEGKIIQE"
     gene            9267..9407
                     /locus_tag="KLF29_RS14830"
                     /old_locus_tag="KLF29_14785"
     CDS             9267..9407
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLF29_RS14830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLF29_14785"
                     /product="hypothetical protein"
                     /protein_id="WP_003470145.1"
                     /transl_table=11
                     /translation="MKLKKSKEKYFKEAIEEYKNKYSKSVDYYKKFKLIRVKIKEELNR
                     I"
     gene            complement(10001..11272)
                     /locus_tag="KLF29_RS14835"
                     /old_locus_tag="KLF29_14790"
     CDS             complement(10001..11272)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="KLF29_RS14835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14790"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_003470140.1"
                     /sec_met_domain="LANC_like (E-value: 4.5e-64, bitscore:
                     208.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLSNKKKLELDNLVINLAKKLAKIEYVEEVLALNETYYKPCSVA
                     VSYPALCVLFSELNYNFPQYNFDVCAHRYLERVNNSLLQNNIYDISLFDGLCGVGFAAN
                     CMSDNGKQYQSFIRNLNEHILNIADRNMLKYKKMPLNETIYDIMYGLTGIVNYLLNFKS
                     ESRVKNTLSNILQYLVDICTISIDGVPKFAIRVNQSQMFSLSNNSRMRYVNLGVAHGIP
                     GILLILCKSYELGICVDNQLEAIKYLSEYIFNNCVKNNNTIFWESQKIIGIENYEAVPA
                     RDAWCYGTPGVAYSLLIASKLLDNDEMNKLAIDAMKLSLNRLREVISPTFCHGLSGLCC
                     LARKFHEYTNDNYFYEMYIKLLKNILDLYSDQYPFGFINKEVEKGQITNKNEIGLLIGT
                     TGVILTILSCYRPIKTQWDSIFLL"
     gene            complement(11244..13079)
                     /locus_tag="KLF29_RS14840"
                     /old_locus_tag="KLF29_14795"
     CDS             complement(11244..13079)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KLF29_RS14840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14795"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_003470127.1"
                     /transl_table=11
                     /translation="MKKFKTLSISEIKEMLSSMKVIPKSIKIFFQVKKSIFIFIIIINI
                     IAGILPVISVNVLGTLINVISTTNLDMSLKILAIYIGISFLLNIVLSIKNFLTTKFQYL
                     LDYELVNKLMNKCANMSLEEFENPDVQDQLKHIQSQIGYRPYSIFTAILTLITSITTIL
                     SSIFSIIIWQPSAILFIITPSLAFSIFYLSISKREFQTEENNAKKSRNIWYYEFLLTKD
                     QSFKEVKILNLAKHLIKRNNDLKKTIIKENLYNTKVRLIISIVFDFIDQICMMALMILI
                     ILSVNAGKLLIGGAVSLLRIINMVFDSFNSIMNIIYSINQNSLYMYKLINFIHEPKIKH
                     GDKKIYRLEEINDIEINDLSFCYPGTNKKVLKNINLKINKGEKIAFFGRNGSGKSTLIK
                     LLLGYYLVDDSMIKINGISLNDINTDNLYKLIGILFQDYCKYELTLKDNVGFGNIDEID
                     NEPQILESLEKAAVDFIPPNLEQQLGKWFSDGIQLSGGQWQRVALARCFFKKAQLYILD
                     EPNAALDKMGEKKIMNTFFELTKNNIGIFVSHKIAHVMLADKIIYLDEGRIVAEGTHEQ
                     LLKTCPSYKEIYDLEFNIPINSKDVDDEFIKQKEA"
     gene            complement(13066..16146)
                     /locus_tag="KLF29_RS14845"
                     /old_locus_tag="KLF29_14800"
     CDS             complement(13066..16146)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="KLF29_RS14845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14800"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_011428898.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.9e-112,
                     bitscore: 366.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-10,
                     bitscore: 34.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.5e-31, bitscore:
                     100.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLFKDVGSFMIRTPSLPIDLLVDNVENSDNIDNIMFLSDSSFY
                     KNQFNEAILVASHDLYESIQRYINGDKVRNMDYLLNSVYKYFSRSCSRCTPFGLFSTVS
                     FGDITFKKTSFELRETELKRKPLIDSNWLFEVVYMYEDRYLKSLKYKINEGVAVYRNKA
                     NLFNCTQNNNSEKINKKSVNYSKAFEIVLEIANDYVSYYEIIENLKKSYPNMDEGIFHT
                     YIHSLIKEDYLISDLRPPLTISNQLEYFISKLIEYDINSDIFIDIKKQIDIYSDESKDE
                     KINCLMNIFNNMKSVYNSKNYLAIDSSFDYKECNLNVNEIKNIDKLINLFIQFNVNDPF
                     DILKEYKDKFLGKYGLSRCVSLIELIDNDIGLGFPSHYDRKTNVNNFGGYINPWVKFFE
                     RKYIESIRINSEIEITDTDIRMLLSENFEKDRLPKTMEIYFNYIKENGKDVFQLSNIFG
                     STYAGKSFGRFSHFMDEPKSFYEKINKAYGNDDECQFCEFAFLPDSLYTANVIRNMNGS
                     KYEISFGTSNSKDNIYKLKLSDILVGFENNKLYLKSAINNKRIVPTSTNMFNPQLKPKI
                     LRLIDDISSDGIRFYNKPWQNLLEKFAYIPTIRYKNFILEQEKWIFKIDDLGLAKRYNF
                     NEFKKGFNEYTKSRNIPSWVYIVDADKKLLLNLKDDRCLSVLQKSLEKSEIILERYNED
                     VEHPVKYNGSSYCCELVIPLMLDGEGYSSKSNDTKFAQICSNDRIKEPLDEWLYFKIYG
                     VEENIDYLLGEALFIPLQELLKNKEIDSYFFIQYKDPDTHLRLRLKADKDRLIAVQPKM
                     FDIFSKLMKQSIIFKYSIDCYELELERYGGYDLMDYAHEVFHKDSIVIQSIIREKNNRN
                     TEISDELLALIIIFFHMIKFKLSLEEMYIFLECDNNTKNNKEEFKKNRDKYVEFAINYL
                     TGKKVTLEEEFILDILSAKNESMEIYLNKIKESYLNDRTVKLSILDSLLHMSMNRLFGP
                     NTDLERKMRNLARHTFYSIYNRNKKTGILDGKKNEKI"
     aSDomain        complement(15427..15642)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KLF29_RS14845_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.90E-11"
                     /identifier="RREFam001.1"
                     /label="KLF29_RS14845"
                     /locus_tag="KLF29_RS14845"
                     /protein_end="240"
                     /protein_start="168"
                     /score="34.2"
                     /tool="antismash"
                     /translation="TQNNNSEKINKKSVNYSKAFEIVLEIANDYVSYYEIIENLKKSYP
                     NMDEGIFHTYIHSLIKEDYLISDLRPP"
     gene            complement(16336..16509)
                     /locus_tag="KLF29_RS14850"
                     /old_locus_tag="KLF29_14805"
     CDS             complement(16336..16509)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429840.1"
                     /locus_tag="KLF29_RS14850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14805"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_003470161.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.8e-19, bitscore:
                     61.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKDFDLNLKMETGSSDDKEPRITSVAYCTPGCLTGELCGSSECG
                     LTRSCTNTWLCS"
     CDS_motif       complement(16444..16509)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLKDFDLNLKMETGSSDDKEPR"
                     /locus_tag="KLF29_RS14850_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16336..16443)
                     /prepeptide="core"
                     /locus_tag="KLF29_RS14850_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="9.30"
                     /molecular_weight="3419.9"
                     /monoisotopic_mass="3417.5"
                     /core_sequence="ITSVAYCTPGCLTGELCGSSECGLTRSCTNTWLCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLKDFDLNLKMETGSSDDKEPR"
                     /leader_location="[16443:16509](-)"
                     /alternative_weights="3437.9"
                     /alternative_weights="3455.9"
                     /alternative_weights="3473.9"
                     /alternative_weights="3492.0"
                     /alternative_weights="3510.0"
     gene            16909..17616
                     /locus_tag="KLF29_RS14855"
                     /old_locus_tag="KLF29_14810"
     CDS             16909..17616
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="KLF29_RS14855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14810"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_003470159.1"
                     /transl_table=11
                     /translation="MGLNIIICDDEFLHRLILKEFLITILNEEFLEYDLIEYSSGKDLI
                     NNYNKADLLFLDIQMNELSGMDVARKIRELDNNVEIIFTTAIEKYVFEAYEVRAYRYLV
                     KPIEYEKLKRQVKLCISDYLIKNSIISIDTNKVTIKIPIGEILYAEVMKKEVTIHTESK
                     IYTIEISMKRVEKKLLNYGFFRCHHSYLVNLNKISEIRNKTIFIKDNEIPISRTRYKSL
                     KIKLVNLLGDSLC"
     gene            17610..18929
                     /locus_tag="KLF29_RS14860"
                     /old_locus_tag="KLF29_14815"
     CDS             17610..18929
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.5"
                     /locus_tag="KLF29_RS14860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14815"
                     /product="ATP-binding protein"
                     /protein_id="WP_003470168.1"
                     /transl_table=11
                     /translation="MLDSKLFLNLLIVISYIIELWSCKKVFDYTNEKKYSNIRINLIMT
                     LIIIFMIFLLQIDINPNIRIIIGIILTFIFYIINYDTSIIIAIITTLIYWLILLMVDEL
                     SMIILIWISSLDNMDMLIFNGSYRLQSIVFGKSILILMLFLYKLIKFKIKLHKKDSLYL
                     KMPIIPNIILFFVVFKYIFKFSELKLISTNEILYILILLFLSSLSTILVIRKIRSNSIL
                     LSQKDMVQNNLKMQYKYYMSIKENQDKIRQLHHDMKNHIICMRKLNQNGYNNEKYIESL
                     DKKIKSYENKFDTGNILLDIILIEKKQICDNKNIKFSSSINFTMCDFIDLEDICSIFSN
                     ILDNSIEACSKINENNKFIFIEGKVVEKFFIIKVENSKVNKINIKNNKFITDKNNKSSH
                     GLGISSIKNSVKKYNGETVIHYTDDRFIIKILIPLIIYKD"
     gene            complement(19090..20311)
                     /locus_tag="KLF29_RS14865"
                     /old_locus_tag="KLF29_14820"
                     /pseudo=""
     CDS             complement(19090..20311)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003482778.1"
                     /locus_tag="KLF29_RS14865"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14820"
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSYAEKELIKKLAKNSNIKTAEDAQNAIKSLFGGLIQQMLEAEME
                     EYLGYSKYDYTNKNTTNSRNGKSKKTVKSDLGLFDLDIPRDREGSFEPQIVKKHQTDIS
                     RLESSIIGMYAKGMSTRDIANQVNEMYGMDVSPTLISNITDKIIPSIKEWQCRPLESIY
                     PIVFMDAIHFKVKKDNSIVNKAAYAAIGVNIEGKKDVLGIWIGTSESSKYWLLVLNELK
                     NRGVKDILIACIDGLNGFKEAIKAVYPNTEVQRCIIHQIRNSSRYLSYKDIKEFNADLK
                     LVYTAVNEDAALQALSSLEEKWGDKYLLAIKSWRNNWEELSTFFKYPPEIRRIIYTTNA
                     IEGYNRQLRKVTKTKTAFPTDEALLKILYLATIDITKKMGSIY"
     misc_feature    21039..21052
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.12"
                     /tool="antismash"
     gene            complement(21097..21552)
                     /gene="tnpA"
                     /locus_tag="KLF29_RS14870"
                     /old_locus_tag="KLF29_14825"
                     /pseudo=""
     CDS             complement(21097..21552)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591496.1"
                     /locus_tag="KLF29_RS14870"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14825"
                     /product="IS200/IS605 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDTNSLAHTKWNCKYHIVFAPKYRRKEIYGEKKQEIGKILR"
     gene            complement(21724..22203)
                     /locus_tag="KLF29_RS14875"
                     /old_locus_tag="KLF29_14830"
     CDS             complement(21724..22203)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLF29_RS14875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLF29_14830"
                     /product="thioredoxin family protein"
                     /protein_id="WP_003470156.1"
                     /transl_table=11
                     /translation="MKKKVYIILILTIILMITSIESLKIISKNYYLKKESLNDKEVYDS
                     FTNKITDINQLINNELSGYIYFGRDTCPNCLKFNEFLKEEYIQKEDLLIYKFDTDYWRN
                     DENFTTVLDKYKISSIPTLILINNDKSYETLEFNNNNENDIESTLHCFLYKNQIN"
     gene            complement(22240..22767)
                     /locus_tag="KLF29_RS14880"
                     /old_locus_tag="KLF29_14835"
     CDS             complement(22240..22767)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022240.5"
                     /locus_tag="KLF29_RS14880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14835"
                     /product="DUF2599 domain-containing protein"
                     /protein_id="WP_003470134.1"
                     /transl_table=11
                     /translation="MKLKFKNIVFLLVSMIILNGIIVQANVLPNKNQITVEILYNSNGE
                     NFAENIVFDDGSRLSDYSYSIKYISAPKEGSKIKEYFNYAAWITRDGITSLSLDPKSNV
                     RTNSSVKNQAWEVLSSETEGFINSEYWQNTKVMKWQYDCHYTFASNKDYWNLEPHRTAS
                     SYLEVVFKKCNP"
     misc_feature    23784..23798
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 13.73"
                     /tool="antismash"
     gene            <24217..>24426
                     /locus_tag="KLF29_RS15280"
                     /old_locus_tag="KLF29_14840"
                     /pseudo=""
     CDS             24217..>24426
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003482778.1"
                     /locus_tag="KLF29_RS15280"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="KLF29_14840"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTNNSCNRKSKKTVKSDLNLFDLYIPRERDGSFEPQIVKKY"
     gene            complement(24671..24910)
                     /locus_tag="KLF29_RS14895"
                     /old_locus_tag="KLF29_14850"
     CDS             complement(24671..24910)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470137.1"
                     /locus_tag="KLF29_RS14895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14850"
                     /product="hypothetical protein"
                     /protein_id="WP_003470137.1"
                     /transl_table=11
                     /translation="MANIERVNLRLNLDDPRDAAIWGLIKDKKNKKGTYIKFLVYNLIV
                     GNEISITKSFVNSYSDKNDISEDEFDDDINNEFG"
     gene            complement(24913..25758)
                     /locus_tag="KLF29_RS14900"
                     /old_locus_tag="KLF29_14855"
     CDS             complement(24913..25758)
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004456847.1"
                     /locus_tag="KLF29_RS14900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_14855"
                     /product="ParM/StbA family protein"
                     /protein_id="WP_042262828.1"
                     /transl_table=11
                     /translation="MIIAVDLGNYNIKTCEGIIFESRYQEVEKEDFDTDLLELENKFYR
                     MESGDFENEFNKAKKNFIPNLLYAISKSCDVDNIETDLVLGVPASNLGISEELKEKLLN
                     KCFNFSLFEVNKNIKINKVATVAEGLSSFYTLPKEERAKDLVILDIGGRTWNICVSSGG
                     KCIMKFTVPGGMIDLYSEIQEDYNKLGNNADVEEIIRLIKNDTIDASKAKERFVKDKLN
                     KVRLKVPNFSTYKIWGAGGGSLDLQDALRENLGNLNFVPDPLFSNVKGNKLIAEAKWGK
                     "
     misc_feature    25752..25766
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.46"
                     /tool="antismash"
     misc_feature    complement(25773..25786)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 26.06"
                     /tool="antismash"
     misc_feature    25792..25807
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.58"
                     /tool="antismash"
     misc_feature    complement(25825..25840)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    25897..25912
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.58"
                     /tool="antismash"
ORIGIN
        1 atatcctaat tttctaaaac cactttcagc aagtttagca ctattataac tatgttttac
       61 agaatcatga ccgaaagctt tagcatgatc acttcctttt tcaatatctc cgcctaatat
      121 ttcgccatta ttagcatcaa catacacttt agtatttccg tcattaatta cccatgcttg
      181 tcttacaaaa tcaactggat tatctaaaaa ttctcctttt tcatcgctca aaaaatagtt
      241 tggtcttatt atttcaaggg tagaagtttt atttgtatta ctttctttat tatctaaatt
      301 cttaaaaatt ttttctgaaa tattaattgc ttcttccttt gttattttta cttctaatgt
      361 ttctggagct tcatcaaaca tattaaaagt ttgtatttca ttattattct tatttacaaa
      421 aacttttact ccttgatatg gattaatcac tccattaggc aattgttttt caaatattat
      481 aattttcata ttttcatcga agtcttcatt ttgtataatt ttgtattcat ttgataaatt
      541 taaagcttct tttatattat taataattat atcttcctta acttcagaag ttaagctcct
      601 tttttttcta accttagtag ctaaattact ttgtataatc tcattattag tgatattttt
      661 tatttttaag ttttctgtta aactaacagt tttattatta tttgataaaa tataaatttt
      721 ttcgttatat aattcatctt ttactaactt aacttctttt aactcatcta aattaaaacc
      781 tatcaaattc aatttatttt caagattatc atcaatatta aatacaagtt cccctttatc
      841 atttttaata ttgttacctt caatattaaa gttttctaat actatttctc cttttattaa
      901 atttttactt tctttagcgt ctacatttat agttccaaaa ctaaaaataa ataaaataaa
      961 aattaataat aagtatttgt ttttcataat atccccccaa ttgttattaa tattagttaa
     1021 aacgttttca agttatacat attataatat attatgaaaa atatgtaaat gtttttttga
     1081 aaatatattg acatataata ccttcgagtt ataatgtgag taaaaatatt gagagggggt
     1141 attaagtatg aatttagtta aaacaagaga tgatttagaa agagaagctc ctagactaaa
     1201 aaaagaatga atacaaaaaa ttgatagtat agataatgca aatagaaaat atgtattaat
     1261 ttttgagaat ctagtattcg aggcagacca tgaacaggat attacttcaa gattaataag
     1321 ggattatata gaaactgatg atagaaatat gcagcttcta tttagaattg attttgcaag
     1381 agctttaagt atgtatagca taatgaatgg aattaatgtt gaagtttata ataacggtaa
     1441 gaaagtaaga gataactatg ctgtttctga agatgattcg gattatgaaa aggactatga
     1501 aattcctgat ataattctgg atgtatttga tgaatttact ctttttaagg gccttaatga
     1561 acttaagtat gctaaaatat actataagtc tgattctgga gagtataagc tattttaata
     1621 taaatttagg ataaagaagt aacttttatt atttaaagct acttcttttt tataaggtga
     1681 acatatgaaa aaaagagaac aaatatatac atttttaata gattttataa aagaaaaagg
     1741 atatcaacct acggttagag aaattgccca tgcagtaaat ttaaagtcat catctactgt
     1801 ttataaacat ttagaaatgt tggaaaaaga tggattaata aaacttggga aaagagaaca
     1861 aagaggtaga aaaagaagta ttcatattat tgatttaaac aaaaagatta aaaaaatgta
     1921 tcagaagaaa ctattaaaaa tctaattaaa ttttcaaaaa aacaagttaa tactaataat
     1981 gatgtatttc ccaagaaagt tactaatgat tatatagtaa ctgtagataa tatatttcct
     2041 gatgacatta ttatcgttga gaaagtaaat tctctagaaa aggatagtat aggattatta
     2101 ttatttgaaa atcatacctt tataaaaaaa atattttcag cttatgaaaa ggtatatgat
     2161 actgatccta tagttttagg gaagattatt ggtgtttata gagatttttt ataatattac
     2221 ttgaaaaaat ataaaagaaa cgttaaaata ggttaacaat attaaagttt actgtaataa
     2281 tatattagaa actttctagt tcacaagtta ataattgaac cagtattaac tattaaatta
     2341 attgcaaact taatttaatc tggatatcta ttaacacaaa aaagattatc tctttaattt
     2401 agagataatc tttttttgtg tttagaatta accaagaata ttatacaatt taattatatt
     2461 ctatactcat agtaattata aattggggta agaaaattta tgagattatc agaagaagat
     2521 aagaaatgta tcaaaattct ttataaaaat ggcttaaatg taaaagaaat tgaaaaatta
     2581 ttaactaata acttttctaa agatgatatt caaaaacata tatagacatt taaaaggatt
     2641 taaaaaggaa catattataa acagggtttt aaataaagat aaattaaaga aagaatttta
     2701 aaatattatt aagaataatt tttaataaag gattttccat aattttcaag aatattattt
     2761 atatattctt aaattagggg gagttaggat atgaaaacag ctcaagaagt agccaatgaa
     2821 ttagatttaa ccaggactga agtttataat ttacttagaa agaaaagatt ttctccatta
     2881 gttaaaaaga atggtggtca agtagcaata agcaatgaac tctttatatt attagaagaa
     2941 gaaattaaaa gtaaacgaaa taacatcaaa caacaagaag ataaattatt agctaaaaaa
     3001 aatactataa ctgatgtaaa aactgaaaaa agtcctgatt ttaatattat agaagttcta
     3061 caaaatcaaa taaaattaaa agataatcaa ataactattt taaatgatgt tataactaat
     3121 aacttaaaga gaataaaaaa tcttgaagaa aaaaatcatg aatttataaa gttgcatgaa
     3181 gaactcaata atttaaaact agttattgat tcaatacaaa ctaaaaaaaa gagaaaaaga
     3241 cttttaggag tattttaaaa gatgaggtta aatgagagtg taaaatagtc tgtgtaaact
     3301 tatgcacaga ctatatctta tacaaaaaaa gaattaataa aacaaattgt taaaacccta
     3361 atataaatac tactaaagat gctcaaaatg ctatttaaag tttatttggt ggtttaattc
     3421 aacaaacgtt taaatttgaa atagaagaat atttatgata ttcaaaatac aattacacaa
     3481 ataaaaatac tactaattct cataatagac aaagtaagaa aactgttaaa tatgatttag
     3541 tgctatttta tttatatata ccccaaaatc gtgatggttc tttctaaaca caaatcgtaa
     3601 aaaatatatt taaactataa agttcaataa ataataggta tgtatgcgaa aggcatgtct
     3661 acacgatata tagctaacca agttaattaa atgtatggca tggatatttc tcctactcta
     3721 atctcaaata taaatgataa aataataact tctacaaaat aattacaatg tagatcatta
     3781 gaaattatat atccattatt ttcatggata ctattcgctt caagctttaa gttcttttga
     3841 ggagaaatag gaagataaat atttaattaa tataaaataa tgaataaata atttgaaaga
     3901 gttatctata ttatcgaagg ctataatagt caattaaaga aacttattga aaataaaata
     3961 aatttttcta cagactaagc tttacttaaa atactttaac ttacaaaaat agatataacg
     4021 aaaaaaatag gttcaatcta ttagaactgt tctcaaatct tagctcaact ttcaatttat
     4081 ttctacgaac gtcttgacga ccatttatac taaaaaaatt taatatacta accctagttt
     4141 ttatacaatt tatattcaat ataattatat aaaaagaaaa aagggttaaa taaattatta
     4201 tctaaacctt aatatatttt tttatatagt ttacacaaaa ttattgatat tctcttttgg
     4261 agtagcacaa atactagctt tgtttgttac tttatataaa attaagaaac ataaatagtt
     4321 ttaaaaaagt ttctatgtct ggttaatatt ataattttat taaattatat attaaataat
     4381 gagttttaag agaattagta attatgaaaa atatttttta atgaataact ttattatatt
     4441 gcgaagtaaa taatttttga aaatttatag tagaataatt tacaaaatat cctataatta
     4501 acttatgatt ctattattgt gtgagttagt ttgattttta agatgtttta aatgtaaaag
     4561 ttattatgag tagccgtatg ctggaaaaca gcatgtacgc attccatgat atacttacat
     4621 tatgagatat aagtctactg aactatctag gagttatata aatcaattaa ctcttattaa
     4681 gaataaaatt ttataaaatt ttcattagtg aaataaaaat ctttatatta taatcaaatt
     4741 aaaatgtttt aaacttagga gaatagttta tgtcgaaatt attagttatt gatgatgata
     4801 ttgatatgtt ggatttagtg cgtgctacat tagaaaaaga tggtcatcaa gtagatactg
     4861 aagtagatgc tactacaata cagcctagta aatgtcaaca atatgatctt ctgttacttg
     4921 atgtaatgat gccgagtgaa aacggctttt ctctttgtag tcgtatacgc tctgaagtag
     4981 attgcccaat tcttttctta actgcaaaag ctgaagatac agctcttgta caagggtttg
     5041 gattaggagc tgatgactat attaagaagc ctttcagtat tgcagaatta cgagcacgag
     5101 taaatgctca cctacgtcga gaagttcgtc agccaacaca cacacttagt agaagtggtg
     5161 tgcgttttaa catgcaagaa aaaatggcta ttgtaggtga ggataccatt ttctttacta
     5221 aaggtgaata tgctataagt gaacacttgg ctttacatat aggacaagta tttactaaag
     5281 aacaattata tgaagctgtt tttggttttg atgctgacgg tgattcatca gctattgtag
     5341 agcatataaa aaatattcgt gctaaactaa aagcttataa ccttaatcct attgaaactg
     5401 tttggggggt aggttataaa tggcgaaaag acaaaattct ataagtcttt cttttgtact
     5461 tttacgtttt actatcatca tgctaggatg tatgttgtct tgtttcataa tatggttaac
     5521 cacattacaa ttactagaaa aaaaagattt tatttatcat ggatcagtat ctaaccaaca
     5581 agtggagaaa atgttagctg gaaaaccatt aaatttcatt tcacctaata ataattttct
     5641 agcaaagtat gctttattta acaaaagtgg tgagatatta gaaagtaatg tagaaggaaa
     5701 agaactagaa atattaacta tgtatttaaa agagaatata aatgatatac atagtttacg
     5761 atatacctac caagatgaaa gtactatagt aattcgttgg aattacagga gagagtttat
     5821 aaatcctact ttacgaaata tacttcctcc ttttgaatat ctatggtggg gtacactagg
     5881 tattgcatgg attctttgct taatctttaa tactttatgg cttagatata atcttgctac
     5941 aaaattgaaa ctatttagtc aagtaagtga aaaagtagct tcacaagagt tggaatttga
     6001 aattcctcat gcaggcataa gggagtatga tcaggcactt gacgctatgg aacatatgag
     6061 aaaagcattg tatacttctt tatctttaca gtgggcagcg aagcaagaac gggagtcaga
     6121 aatagaatct cttgcacatg acttaaaaac tccacttacc ctaataggtg ggaatgctga
     6181 acttctgtta tatgaagact tacctgataa tactctaaaa atggtgaaaa caatcatatc
     6241 aagcaatgat agagcaaaaa actatgtagt aagtctacta gaagcttcaa tagggataga
     6301 tgaagagttt gaaaaaataa gattatacga tttacttgat aagttatatc aaaatactat
     6361 gcctattgca gaaaataaga aaatttattt gcaaaaaaaa aataaattag atggtattgc
     6421 aaatatacag gaagaacgct tgcttcgagc tttaggaaat atagtacaaa atgctattga
     6481 acatacaaat gcaggtagaa atgtctattt agaaggtaaa atgataaatg gcggatggca
     6541 aattattgtg cgtgatgaag gtcctggttt cagtaaggca gcactacaac acgcaactaa
     6601 acgcctttgg cgtgatgata cagctcgtgc caagagtaat cataatggaa ttggactatg
     6661 gtttgcttta caagtagtaa aaatgcattc aggtcagatt aaactacaaa actatgattg
     6721 tggtggattg gtaacaatcg aatttaaata aacattagct tatcacaaaa aactgagtaa
     6781 gtaccgatta actatttagt aatgcattaa tcgaaagatt taagtcactg gaagatattc
     6841 tagtgactta cttttttatt caaatggaat atttttattt ccttataaaa tccttataat
     6901 tggttgttat tataattatt gttaaatgta ggaattataa atattctacg aaatgttctt
     6961 tattaaataa aaaaggaaag aaggtaataa taatgcatga atatattcta aaaacaaata
     7021 gtgtttctaa aaaatttaaa aagacatatg cagtaaaaaa tttatcaatc tctgtaagaa
     7081 gaaattctgt ctatggtcta ttaggaccta atggtgcagg taaatctacc ttattaaaga
     7141 tgattgcagg aattgttaga cccacatcag gtgaaatatt attcaataat catgattgga
     7201 cacgaaaaga tttgttagat attggttcat tgattgaatc accaccacta tatgagaact
     7261 taactgcatt tgaaaattta aaggttcgtg caatactttt aggtattcca ctaaaaaaat
     7321 gtaatgaagt tttagaaaaa atggacttaa tggatacaaa aaataaaaaa acatcagatt
     7381 tttcattagg aatgaagcaa aggttgggaa ttgcattagc attattaaat aatcctaaac
     7441 tacttatttt agatgagcct acaaatggac tagatccttt tggaattgaa gaattaagaa
     7501 aaatgattcg aagattagta gactcaggaa tttctattat tatatctagc catattttaa
     7561 gcgaaataca acaagttgct gatgatattg gaattatata taatggaaca ctcctatatg
     7621 aagattcagt taatgcaagt gaagatttag agcaattgtt tatggatatt ataagaaagg
     7681 agcgtcaatc ctaatgttac aatcatattt aaaagcagaa agtttaaaat ttaagcactc
     7741 actattcaga aaactcacca tcttaatacc attagcttta attttgatag ctatgatttt
     7801 catgtttgtt ggtattggtt taggaggctt ttcaagttct atagtttgta attggagtat
     7861 gccaattgca tcattatcaa ttatgttttt atgtcatcaa gtgaataaaa aagaaaaaaa
     7921 gcataaatat agaacgcttt atagtttgcc tattgatcta aagaaaatat ttatttcaaa
     7981 gacaattttg atagcactta accttttagt aatatcattg ctattgtcat ttatatctat
     8041 tatctctgaa ttagtattat caggattttc agtagcaatt gtatatattg gacattatat
     8101 tttaggatat attctattat ggttttcttt attatggcaa atacctttat gcttattttt
     8161 agatcaaaaa gtagggttta ttgcttctat tatactaagt ttattcttaa gtgctttcgg
     8221 tggattattc tttgcattga ctcctttatt ttggattttc ccatatagct ggactgctag
     8281 attgatgact acattatttg gagttttacc aaacggatta ttagttgaat caggttcaaa
     8341 atatatttta agtttaggcc aaagttcatt tttaatatta atttctatat ttattgtagt
     8401 tgcatttacc ggcttgtttt cagtttggta tggaaagcag gtgtatcgta aatgataatt
     8461 ttgagagagt tcagttctaa ttttatcaaa ttaaaacgaa cttcccttct tttattacat
     8521 ttgttaacac ctatagtgat tacattttta tttctttact attacactat ttcaggatat
     8581 catatcatta ctgacgtaag agtatttttt attatactac agatgtgtta tccaattttt
     8641 ataggtattt ctgtatctgc ttttactcaa ttggaaagaa atataaacgc tattcaaaat
     8701 actctaggac tagtggaatc acgaataagt atttacctag ggaaactatt atttatgcta
     8761 tttctatcag caataaattt aatactttat gaattatgtt tttatattgg taccaattta
     8821 tttttagata tgaatatatt ttcattgaat ttatatgtcg gtatatttct aatattctta
     8881 cttagtaact tgtttatata ttcattacat ttatcaattg cttttcgatt cggatctact
     8941 gtctctgttt tactaggaat agctggtaca attctagcag gttactttca aactgatatc
     9001 ggcgataaaa tttggccaat aattccttgg gaatgtggta tcagattttt agaaaactat
     9061 ttgaattttt caaattcacc tattattttt ggaattgctt ctatgattat tttgacttct
     9121 attattctga ttttatcaat tttatggttc aatagatggg aaggaaaaat catacaagag
     9181 taaaatacac gtaaagatta tgttaaaaca aagaaggaga tgtatatatt tatgaagaat
     9241 actctgagaa cataaaaata ttatatatga aactgaagaa gtctaaggaa aaatatttta
     9301 aagaagctat tgaagaatat aaaaataaat atagtaaatc ggtagattat tataaaaagt
     9361 ttaaattaat aagagttaaa ataaaagaag agttaaatag aatataattt atattaatct
     9421 ttccatattt ttaagtcaga atgataaatt aaaatgttta ccgataaaaa aactcttagg
     9481 tatttctacc taagagtttt tttattgagc aaataattaa ataaggaaaa atcctatata
     9541 aataggtaag tggttaatgg aatactacta taaaatgctg gtagaatcac caccaataac
     9601 atctcggtta gcttgaatgt cttaatagaa catttaaatt ttcttattgt atgaattgtg
     9661 attattgtag tgaaaatggt gctatttatg gtattaatct ttttaataat tttacatatg
     9721 caagaatcta aaaattcttg ataaataata aaattaaata tcaatccaac ttttcctaag
     9781 atattgaatg attctttgtt atacttaaat ttagagtaaa attataatta ttaaattaaa
     9841 atatattcat ttattttaat tatatctatt ttttcatacg aaactttaca ctatttctca
     9901 atataataat tgatactacg ataaaaataa tcataattat taattgctta tcatttaagt
     9961 aaaaataaat tatgataatt cacacaagct attagtattt ttataatagg aatattgagt
    10021 cccattgtgt tttaattggt ctatagcaag ataaaattgt caagattact cctgtagttc
    10081 ctattaataa acctatttca tttttatttg tgatttgacc tttttctact tccttattta
    10141 taaatccaaa cggatattga tcgctatata aatctagtat atttttaagt agttttatat
    10201 acatttcata aaaatagttg tcattggtgt attcatggaa ttttctagcc aaacaacata
    10261 atcctgaaag cccatgacaa aaagttggag atataacttc acgcaaccta tttagagata
    10321 gtttcatagc atcaattgcc agtttattca tttcatcatt atccagcagc tttgaagcaa
    10381 tcaataatga atatgcaact ccaggagttc cataacacca tgcatctctt gctggcacag
    10441 cttcataatt ttctatccct attatttttt gactttccca aaaaattgta ttattgtttt
    10501 ttacacaatt attgaaaatg tattctgata aatattttat tgcttcaagt tggttatcaa
    10561 cacatattcc caattcataa gatttgcata atatcaaaag tattccaggt attccatggg
    10621 caacccctaa atttacatat cgcattctag agttattcga taaagaaaac atctgacttt
    10681 ggtttactct aatagcaaac ttaggaactc catcaatact tattgtacaa atatcaacca
    10741 aatattgcaa aatatttgat aatgtatttt taactctact ttcagattta aaattcaaca
    10801 aataattaac tataccagtt aaaccataca taatatcgta aatagtttca tttaatggca
    10861 tttttttata cttcaacata tttctatctg ctatatttaa aatatgttca tttaaatttc
    10921 ttataaaaga ctggtattgt ttaccattat ctgacataca atttgctgca aaccccactc
    10981 cacataatcc atcaaataag gaaatatcat aaatattatt ttgcaaaaga gagttattta
    11041 ctctctctaa atatctatga gcacatacat caaaattata ttgtgggaaa ttataattaa
    11101 gctctgaaaa caatacacat aaagcgggat atgaaactgc tactgaacaa ggtttataat
    11161 atgtttcatt taaggctaat acttcttcaa catattctat ttttgctaat ttctttgcta
    11221 aatttataac taaattatct aattcaagct tctttttgtt tgataaattc atcatcaaca
    11281 tccttactat ttataggtat attgaattct aaatcataaa tttctttgta agaaggacat
    11341 gtttttaata attgttcatg cgtgccttct gccactatcc tgccttcatc aagataaatt
    11401 attttatccg ctaacattac atgtgcaatt ttatgagaaa caaatatacc tatattattt
    11461 tttgtaagtt caaagaaagt attcataatc ttcttttcac ccattttatc aagtgctgca
    11521 tttggttcat ctaaaatata caattgtgct tttttgaaaa aacaacgagc taatgcaacc
    11581 ctttgccatt gtcctccaga tagttgaatt ccatccgaaa accattttcc taattgctgt
    11641 tctaaatttg gtggaataaa atctacagct gctttttcta gagattctaa tatttgaggc
    11701 tcattatcaa tttcatcaat atttccaaac ccaacattat ctttaagtgt tagctcatat
    11761 ttacagtaat cttggaacaa tatacctatt aatttatata aattatcagt attaatgtca
    11821 tttaatgaaa taccattaat cttaatcata ctatcatcta ctaaatagta tcctagtagt
    11881 aattttatta atgtactttt cccagatcca tttctaccaa aaaatgcaat tttttctcct
    11941 ttattaattt ttaaattaat atttttaaga acttttttgt ttgttccagg ataacaaaat
    12001 gataaatcat ttatttcaat atcatttatt tcttcaagcc tatatatttt tttatcacca
    12061 tgttttattt tcggctcatg tataaaattt atcaatttat acatatatag actattttgg
    12121 ttaatactat aaattatatt cattatacta ttaaaactat caaataccat atttataatc
    12181 ctaagaagtg aaacagcgcc acctattaga agtttaccag cattcactga tagtattatt
    12241 agtatcataa gtgccatcat acatatttga tcaataaaat caaacactat agaaattatt
    12301 aaacgtactt ttgtgttgta tagattttct ttaataatag tcttctttaa atcattattt
    12361 ctctttatga ggtgtttagc caaatttaaa attttgacct ctttaaatga ttgatcttta
    12421 gtaagtaaaa attcataata ccatatattt cttgactttt tagcattatt ttcctcagtt
    12481 tgaaattctc ttttgcttat tgataaatag aatattgaaa aagctaatga tggagtaata
    12541 ataaacaata ttgctgaagg ttgccatatt attatgctaa aaatggatga aagtatagta
    12601 gtaattgaag ttatcaatgt caatattgca gtaaaaatac tataaggtct ataacctatt
    12661 tgtgattgaa tgtgttttag ctgatcctgt acatcaggat tttcgaattc ttccaaagac
    12721 atattagcac acttattcat tagcttgtta accagttcat aatctaataa atattgaaac
    12781 ttggtagtca aaaaattttt tatacttaag acaatattta atagaaaact gattccaata
    12841 tatattgcta atatctttaa agacatatca agattagtgg ttgatattac attaattaaa
    12901 gtacctaaaa cattaacgga aattactgga agaataccag cgataatatt tattattatt
    12961 ataaatataa atattgactt tttaacttga aaaaatatct taatagattt tggtatcact
    13021 ttcatggaag aaagcatttc ttttatttct gaaatactta atgttttaaa ttttttcatt
    13081 tttcttacca tccaatattc ctgttttttt gtttctatta taaatactat aaaatgtatg
    13141 cctagctaaa tttctcattt ttctctctaa atctgtattt ggcccaaaca atctgttcat
    13201 actcatatgc aacaaactat caagtatgct tagctttaca gtcctatcat taagataact
    13261 ttcctttatt ttatttaaat atatttccat agattcattt tttgcagata gaatatctaa
    13321 aataaattct tcttctaacg ttactttttt tccagttaaa taatttattg caaattcaac
    13381 atatttatct ctatttttct tgaattcttc tttattattc ttggtattat tatcacactc
    13441 aagaaaaata tacatctctt ctaaactcaa tttaaattta atcatatgaa aaaatattat
    13501 tatcaaagct agaagttcat cagaaatttc tgtatttcga ttattttttt cacggattat
    13561 tgattgaatt actatgctat ctttatgaaa tacttcatgt gcatagtcca tcaaatcata
    13621 accaccatac ctttctagtt ctaattcata acaatcaatg ctatatttaa agataattga
    13681 ttgtttcatg agtttactaa aaatatcaaa cattttaggt tgaaccgcta ttaacctatc
    13741 cttgtctgct tttaatctca atctcaaatg cgtatctgga tctttatatt gaataaaaaa
    13801 ataactatct atttctttat tttttagtaa ttcttgcaat gggataaaca aagcttctcc
    13861 taataaataa tctatatttt cttcaactcc atatatttta aaatataacc actcatctaa
    13921 aggctccttg attctatcat tactacagat ttgagcaaat ttagtatcat tgcttttact
    13981 tgaatagcct tctccatcta acattaaagg tataactaat tcacagcaat aagatgatcc
    14041 attatactta acaggatgtt ctacatcttc attatatctt tcaagaataa tttctgattt
    14101 ttcaagtgat ttttgtaaaa ctgataaaca tctatcatct ttaagattta ataaaagttt
    14161 tttatctgcg tccacgatat atacccaact aggtatattt cttgacttag tatattcatt
    14221 gaatcctttt ttaaactcat taaaattata gcgtttagct aaacctaaat catctatctt
    14281 aaaaatccat ttttcttgct ctaatataaa atttttatat cgtattgttg gaatataagc
    14341 aaatttttca agtaaatttt gccatggctt attataaaat ctaattccat cagaagagat
    14401 atcatcaata agccttaata ttttaggctt taactgcgga ttaaacatat ttgttgaagt
    14461 aggaactatt cttttgttat taatagcaga ctttaaatat aatttgttat tttcaaatcc
    14521 tactaaaata tcgcttaatt taagcttata tatattatct ttagaatttg atgttccaaa
    14581 actaatttca tatttggaac cattcatatt tcttataaca tttgcagtat ataaactatc
    14641 aggtaaaaaa gcaaattcac aaaactgaca ttcatcatca ttcccatatg ctttattaat
    14701 tttttcatag aaagattttg gctcgtccat aaaatgagaa aatctaccaa acgacttccc
    14761 agcataagtt gatccaaata tattacttaa ttgaaatacg tctttaccat tttctttgat
    14821 ataattaaag taaatctcca tagtttttgg caatctatct ttttcaaaat tttcagacaa
    14881 aagcattctt atatctgtat ctgtaatctc tatttcacta tttattctta tggactctat
    14941 atattttcgt tcaaaaaatt taacccatgg attaatatat cctccaaagt tattaacatt
    15001 agtttttcta tcataatgag atggaaaacc taatccaata tcattatcaa taagttcaat
    15061 taatgaaaca catctagata acccatactt gcccaaaaat ttatccttat attcttttaa
    15121 tatatcgaat ggatcattaa cgttaaattg tataaataaa ttaatcaatt tatctatatt
    15181 ttttatttca tttacattta aattacattc tttatagtca aaagaagaat ctattgcaag
    15241 gtaatttttt gagttgtata ctgatttcat gttattaaaa atattcatta aacaatttat
    15301 cttttcatct ttactctcat cagaataaat atcaatttgt ttttttatat caataaaaat
    15361 gtcgctgttt atatcatatt caataagttt agagataaaa tattctaatt gattagatat
    15421 agtcaatggt ggtcgtagat cagagattaa ataatcttct tttattaaag agtgaatata
    15481 tgtatggaat attccttcat ccatattagg atatgatttc ttaagatttt ctataatttc
    15541 atagtaactt acataatcgt ttgctatttc taaaactatt tcaaatgctt tagaataatt
    15601 tacagatttt ttatttattt tttctgaatt attattttgt gtgcaattga ataaattcgc
    15661 cttatttcta taaactgcaa caccttcgtt tattttatac ttaagagact ttaaatatct
    15721 atcttcatac atataaacca cttcaaataa ccaatttgaa tctatcagtg gttttcgttt
    15781 cagttcggtt tctcttagtt caaatgatgt ttttttaaaa gtaatatccc caaaagaaac
    15841 agtagagaat aaaccaaatg gagtacaacg agagcagctt ctactaaaat acttatatac
    15901 agaatttaat aaataatcca tattccttac cttgtctcca tttatataac gctgaataga
    15961 ttcatataaa tcatgacttg ctacaagtat agcttcgtta aattgattct tgtaaaaaga
    16021 agaatcagat aaaaacataa tattatctat attatctgaa ttttcaacat tatctactaa
    16081 taaatcaatt ggtagacttg gagttcttat cataaaagaa cctacatctt taaataactg
    16141 tttcattttt ttcaccagac ccttcctttt tttacataaa ttatattccg cattctaaac
    16201 gtttaaatat attgctttta ttaaacatta aattcaaggc taattttaag atatttcttt
    16261 aacaaaatta aaacgccatg cattcagacg aatgcctaaa tgcatgaacg tttaaggttt
    16321 atatcagtat tgtaattatg agcataacca tgtgtttgtg cagcttcttg ttaaaccaca
    16381 ttcacttgat ccacataact ctcctgtcag acaaccaggt gtacaatatg caacacttgt
    16441 aatacgtggc tccttgtcat ctgatgaacc tgtttccatt tttagattta aatcaaaatc
    16501 ctttaacata atatcctccc ccttatctaa atttctataa taatgtatat aaattaggtt
    16561 tcatatttat cctttaaata tattgaattc ccaaatatta aaggcgataa cctacattat
    16621 tatttaaata acttttaatt tcctacacct attttaaaaa ataatatatg ttttaatatc
    16681 gtgttttttc tttagtatac tatatatata tcatctacta tacaattaat tcaagtatat
    16741 ggaataagtt gtaaatatat agtataattg gttattatat aaaaaataaa agtagatttt
    16801 taagtaatat aaaaaagaaa ataaaattag ttatataatt cagaaaaaga gttaagctct
    16861 aaaaatgtaa aattaaatct tcataagtaa gagttttggg aggttattat ggggttaaat
    16921 ataattattt gcgatgatga atttttacat aggttaattt taaaagagtt tttaattaca
    16981 atattaaatg aagagttttt agaatatgat ttaatagaat atagctctgg taaagattta
    17041 ataaataatt acaataaagc tgatttatta tttttagata ttcaaatgaa tgaattatca
    17101 ggaatggatg tagcaaggaa aattcgagaa cttgataata atgttgaaat aatattcact
    17161 acagctatag agaaatatgt ttttgaagca tatgaagtaa gagcatatag atatttagta
    17221 aaaccaatag agtatgaaaa acttaaaaga caagtaaaac tttgtatatc tgattatcta
    17281 atcaaaaata gtattatatc aatagataca aataaagtta caattaaaat accaataggt
    17341 gaaattttat atgctgaagt tatgaaaaaa gaggttacta tacatacaga gtctaaaatt
    17401 tatactattg aaattagtat gaaaagagtt gagaaaaagc ttttaaatta tggatttttc
    17461 aggtgtcacc atagttattt agttaattta aataagatta gtgagataag aaacaagact
    17521 atttttatta aagataatga aatacctata agcagaacaa gatataaatc attaaaaata
    17581 aaattagtta atttattagg agattcttta tgttagacag taagttattt ttgaacttat
    17641 taatagtaat atcttatata atagaattat ggagttgtaa aaaagtattt gattatacaa
    17701 atgaaaaaaa atatagcaat ataagaatta atttaataat gactttgatt ataatattta
    17761 tgatattttt attacaaata gatataaatc ctaatattag aattattata gggataattt
    17821 taacatttat tttttatata attaattatg atacaagtat tattatagca ataataacaa
    17881 ctttaattta ttggctaatt ttattaatgg tagacgaact aagtatgatt atattaatat
    17941 ggattagttc attagataat atggatatgc taatttttaa tggttcatat agattacaat
    18001 caattgtttt tggaaaaagt attttaattt taatgttatt tttatataaa ttaattaaat
    18061 ttaaaataaa attgcataaa aaagattctt tatacctaaa aatgcctata atcccaaata
    18121 tcatattatt ttttgttgtt tttaaatata tattcaaatt ctcagagcta aaattaatta
    18181 gtacaaatga aatactctat atattaatat tattattttt atctagctta tcaactatat
    18241 tagttataag aaaaattaga agtaatagta tcttattgtc tcaaaaagac atggtgcaaa
    18301 ataacctaaa gatgcaatat aagtactata tgagtataaa agaaaaccaa gataaaataa
    18361 gacaattgca tcatgatatg aaaaatcata ttatttgtat gcgtaagctt aatcaaaatg
    18421 gctataataa tgaaaaatat atagaaagtc tagataaaaa aattaaaagt tatgaaaata
    18481 aatttgatac tggaaatata ttattagata ttatattaat tgagaaaaaa caaatctgtg
    18541 ataataaaaa tataaaattt tcaagcagta taaactttac aatgtgtgat tttatagact
    18601 tagaagatat atgtagtatt ttttcaaata tactagataa ctcaatagag gcctgctcta
    18661 aaataaatga aaataataag tttatattta tagaagggaa ggtagtcgaa aagttcttta
    18721 ttattaaggt tgaaaatagt aaagttaata aaataaatat taaaaataat aaatttataa
    18781 ctgataaaaa taataagagc tctcatggat taggaataag tagtattaaa aattcagtaa
    18841 aaaaatataa tggtgaaact gtaatacatt atacagatga tagatttata ataaaaatat
    18901 taataccact tataatatat aaagattagt taattttaga gaatgtcaat aattttgtgt
    18961 aaactatcta aaaaaatata ttgaaatttg ttgaggttta gatattgatt tatttaaacc
    19021 ttaattttct ttttatgtaa ttatattgaa tataaattgt acaaagacta gatctattat
    19081 attaaatttt taatataaat ggtcgtcaag acgttcgtcg aaataaattg aaagttgtgc
    19141 taagatttga gaccattccc taatagattg aacccatttt ttttgttata tctattgttg
    19201 caagataaag tattttaagt aaagcttcat ctgtaggaaa agctgtttta gttttagtaa
    19261 cttttcttaa ttgtctgtta tagccttcta tagcattagt tgtatatatt attcttcgta
    19321 tctccggtgg atatttaaag aatgtagata gctcctccca attgtttctc caagatttta
    19381 tagcaagtaa atatttatct ccccatttct cctcaagaga acttaacgct tgaagtgcag
    19441 catcttcatt tactgcagta tatactagtt ttaaatcagc attaaactct ttaatatctt
    19501 tatatgataa ataacgacta gaatttctaa tttgatgaat aatacaacgt tgtacctcag
    19561 tattcggata tacggctttt atagcttctt taaagccatt taatccatct atgcaagcta
    19621 taagaatatc tttaactccc ctgtttttta attcatttaa aacaagtaac cagtactttg
    19681 aagattccga agtaccaatc caaataccta aaacatcttt cttaccttca atgtttacac
    19741 cgatagcagc gtaagcagcc ttattaacta tagaattatc ttttttaact ttaaaatgaa
    19801 tagcatccat aaaaacgata ggatatatac tttctagtgg tctgcattgc cattctttta
    19861 tagaaggtat tattttatca gttatatttg agattagagt aggagaaacg tccatgccat
    19921 acatttcatt aacttgatta gctatatctc gtgtagacat gcctttcgca tacataccta
    19981 ttattgaact ttctagtcta gatatatcag tttgatgttt ctttacgatt tgtggttcga
    20041 aagaaccctc acgatctctt ggtatatcta aatcaaataa ccctaaatca gatttaacag
    20101 ttttcttact tttcccatta cgagaattag tagtattttt atttgtataa tcatattttg
    20161 aatatcctaa atattcttcc atttcagctt caagcatttg ttgaattaaa ccaccgaata
    20221 aacttttaat agcattttga gcatcttcag cagtctttat gttagaattt ttggcaagtt
    20281 tttttatcaa ttctttttcg gcataagaca tagtctgtgc accctccttt tgtatgatac
    20341 ttaattatat cattttagta gtttacacag actattttac actctcttat tttaaattat
    20401 ttatattaaa ttatgttata gtattgaata gtaatggaac cccaaatatt attttttata
    20461 atatttaatg tttaattaga aaattcttag cagtatatag ttactgtatt tattataaaa
    20521 aaatatatat tttatgtgct taaggtcagt aatatttatt ataaatatat ttataatagt
    20581 gacagtaaat catataaata atcaactaga taatttagaa aaaatataat ataaatattt
    20641 atattaataa ttacttgtaa tactaatagg attattttta gatttatcaa tattttattt
    20701 gaatttttgt ttattttact gataatcaaa aataaaaatg aatagatttt ttaggagaaa
    20761 tacattagaa atttattaat ttttgtaaca tatatatatc caaatttaac ttatttaaag
    20821 aagttgatat tgttgaatat tatttaaaca ataggactaa aaataacctt agatataaga
    20881 caatttttta agtatttacc aaataatagt taagtgttgc atttagcttt acaattgatc
    20941 atatataaaa aaggtaataa aatatatcaa taatattacc tgtaaataat aaaaatccac
    21001 cagcttagct ggtggtattt cctccttagc cctataaggg catactacct gcgttgcgtc
    21061 ttaagaagct tagattagtg ccagccgcat actcctttac ttgctaccct taaaagggtc
    21121 cgtatattct tttaaactta tttgatcagc tatcatatct tcttgttctt gatttcttat
    21181 atagtcttta atttccttct tattttttct cacagtatca acgtaaaatc ccctacacca
    21241 gaaatgtcta tttccatatt tatattttaa atttgcaaat ttctcaaaaa tcataagact
    21301 acttttacct tttagaaacc caacgaaact tgaaacactc attttaggtg gtatttcaac
    21361 aagcatgtgt atgtgatcta cgcaagcgtg cgcttcgact atcctaaccc ctttccattc
    21421 acaaagctac cttaatatct tacctatttc ttgttttttc tctccatata tttctttcct
    21481 tctgtatttt ggtgcaaaaa ctatatgata tttacaattc cattttgtat gtgctaaact
    21541 gtttgtatcc atttaaaaac ctccttttgt taaaatgagg ttttttctta catcgctaaa
    21601 gctcttctga acacactcgc atagcgagtg gttttcatta aacaaaaaaa tattaccgca
    21661 aataaaaatt tccagtaata ttaataaaat aaatatatta aatacacaaa acaatctagt
    21721 ctattaattg atttgatttt tatataaaaa acaatgtaga gttgattcaa tatcattttc
    21781 attattattg ttaaattcaa gagtttcata tgatttatcg ttgttaatta atatcaaagt
    21841 gggaattgat gatattttat acttatccaa tacagtagtg aaattttcat catttctcca
    21901 gtaatcagta tcaaacttat aaattaataa atcttctttt tgaatatatt cttcttttag
    21961 aaattcatta aatttcaaac aattaggaca agtatctctt ccaaagtata tatacccaga
    22021 tagctcatta tttattaatt ggttaatatc agtaatttta tttgtaaaag aatcataaac
    22081 ttctttatca tttagtgatt ctttttttaa ataataattt ttactaatta tttttaatga
    22141 ttctatagaa gttatcatta gtattattgt taatattaat ataatatata cttttttctt
    22201 catgtatttc tcctaattaa atagatttta ttatttattt taaggattac atttcttaaa
    22261 tactacttct aaataacttg atgcagttct atgaggttct aaattccaat aatctttgtt
    22321 tgaagcaaaa gtataatgac aatcatattg ccatttcatc actttagtat tttgccaata
    22381 ttcactattt ataaatcctt cagtttcgct tgataacact tcccatgctt gatttttaac
    22441 actagaattt gttctaacat ttgatttagg atcaagactt aatgatgtaa ttccatctct
    22501 tgtaatccaa gcagcataat taaaatattc tttaattttg gacccctcct taggtgctga
    22561 gatatatttt atagagtaag aataatctga taatcttgaa ccgtcatcaa atacaatatt
    22621 ttctgcaaaa ttctccccat tactattata aagtatttct acagttattt gatttttatt
    22681 aggtaatacg ttagcttgta ctattattcc attaagaata atcatgctaa ctaataaaaa
    22741 tacaatattt ttaaatttta acttcataaa ccttccccct tatatttact ttacataatt
    22801 ataataccat tatttataaa ttttggaaac tatttatttt attataagat taatttaatg
    22861 ttgattaata aaacataagt taaaatttta tatgtggaat attaatataa gtaaaaaatt
    22921 tcaatatatg ggttattaga actgagtatt acagaaaact caaccctaat taaaatatta
    22981 gcaggaataa tttatcttat gtaaacattt actacataag taaaagtttt aatatattca
    23041 tattaattta aacgtaaatt aatattagta gaaatgactc aaagtatatc tagagtaagt
    23101 aaatatataa acttatacaa taataaaaaa taacaaaaaa aagattaaac ggcctagctt
    23161 tagcaattta aaataattct tattattttc actgtttact ttataagggt aagttaagat
    23221 tgaaattatg gtaagtttta ttatcaaaac ttaaaaagta tcaagtattg attacagtat
    23281 ttaaaggagt tgctaaagat ttgtattcaa aagatcgtaa atactatata tcattagata
    23341 atagtatcaa aagtgtaata agtaataaat taatagatta tgctatggtc aaccattaag
    23401 caataaatgt aaatttatta gagcaaaaca attagactca ataacaaata gatattctac
    23461 tgaaattata tatgaaaaaa ggaaaagtag tgttaaataa agaagagtat ttaataaagt
    23521 aatagcagct ttgaattatg tgatacctta gtagttataa ttagatagat tctacaaaac
    23581 tgtaaaacag tgattagaaa taatatattt acttatgaat aaatgtataa taatatattg
    23641 aatattgggt taatagaaga catacaaatg ggaaaattaa taataactaa ttttttagca
    23701 ttttcaaaat ttgagcaatc tattatagtt aatataatct aaatatggga taaaatatca
    23761 aaaacaaaag aagtttggaa agaaggacgt tcgaaacttt ggactaatga aaatctagac
    23821 aacatgttat ctatgttaat agtaaatgag gaatagaatc tataaagaag tagaaatatt
    23881 atttagaata agtaaaagta cattaataag cgaaaatttg aaagagacac gtgttggtag
    23941 taaataggtt aagtgaggga gtagcgatat gtttcagagt aatatgataa aaaagttaat
    24001 ttataaaata caaaaaagga gaatatcttg ttttatataa taaatataaa tgccgattaa
    24061 tattgaggtg ttatattagt atgatataaa gcaggttgta catataatag gatttagtaa
    24121 aaataaatta ataaaagaaa attaagaaat aaaaaagctt ttagttagag agaataaaaa
    24181 atatatgctt tagaagatgg aatagactta ttaattaata ctaataattc ctgtaataga
    24241 aaaagtaaga aaactgttaa atctgattta aatctatttg atttatatat accaagagag
    24301 cgtgatggtt ccttcgaacc acaaatcgta aaaaaatatt aaactgatat atctatacta
    24361 gaaagtatat atcctattgt tttcatagat actattcact ttaaagtgaa aaaatataat
    24421 tatataaata tccacagtaa ctacgaaaaa taatacatac aactaatatt atagaagtct
    24481 ataatagaca attaagaaaa gttactaaaa ctaaaataac ttttcctaca gacaaagctt
    24541 tacttattta atataattaa atataaaaaa attaaggttt aaatagatta ttatttaaac
    24601 ctcaataaac ttcaatattt ttttagataa tttacaccaa attattgata ttctcaatta
    24661 accttccttt ttaaccaaac tcattattaa tatcatcatc aaattcatct tctgaaatat
    24721 catttttatc actataagaa ttaacaaaac ttttagtaat acttatttca ttaccaacaa
    24781 tcaaattata aactaaaaac tttatataag ttcctttttt attcttctta tcttttatta
    24841 aaccccaaat agctgcatct ctaggatcat ctaaatttaa tcttaggtta acacgttcta
    24901 tatttgccat aactatttac cccatttagc ttcagctatc aatttattac ctttcacatt
    24961 actaaataaa ggatccggaa caaagtttaa atttcctaag ttttctctta atgcatcttg
    25021 taaatctaaa ctaccaccac cagctcccca aattttataa gtagaaaaat taggaacttt
    25081 aagtctaacc ttatttaatt tatctttaac aaatctctct tttgctttac ttgcatcaat
    25141 agtatcattc ttaattagcc ttattatttc ttcaacatca gcattattac ctagcttatt
    25201 atagtcttct tgtatttcag aatataaatc tatcatacca ccaggaacag tgaatttcat
    25261 aatacactta ccaccagaag atacacatat attccatgtc ctacctccta tatccaatat
    25321 cactaaatct tttgctcttt cttctttagg taaagtataa aatgagctta gtccttctgc
    25381 aactgtagca actttattta tttttatatt tttattaact tcaaataaac taaaattaaa
    25441 acacttatta agaagttttt cttttaattc ttcacttatt cctaaattag aagctggtac
    25501 tcctaatacc aaatcagtct ctatattgtc cacatcgcat gattttgaaa ttgcataaag
    25561 taagttaggt ataaagtttt tcttagcttt attaaactca ttttcaaaat ctccagattc
    25621 cattctataa aatttatttt ctaattctaa aagatctgta tcaaaatctt ctttttctac
    25681 ttcttgatat ctactttcaa atatgattcc ttcacatgtt ttgatattat aatttcctaa
    25741 gtcaactgct attatcaatt ttaaaacctc cattttttta aaaaatcatc ggttactcaa
    25801 aagttacttt aaagtgtttt ataagtgact tttaagtgac ttatactatt ataatatcat
    25861 aaagtaactt aaaagtcaac ttttaaccac ctaaaagtta cttttaagtt acttttagaa
    25921 aaatgtaatg aaaaagagag taaaattttc tataatttta ctctcttgaa aaattatttt
    25981 taacatggta ttattaactc aattaaatta aatagtacga aaaaggaaaa atccattaag
    26041 tttcctagtc gccaaacaaa gtaaacttaa tggatgaacc taaatcctaa atagaacaaa
    26101 gttctatttg aaatattcac ttttcatagc tttatgatat caaagc
//
