LOCUS       NZ_CP075970            21584 bp    DNA     linear   CON 27-NOV-2024
DEFINITION  Clostridium perfringens strain C269 chromosome.
ACCESSION   NZ_CP075970
VERSION     NZ_CP075970.1
KEYWORDS    RefSeq.
SOURCE      Clostridium perfringens
  ORGANISM  Clostridium perfringens
            Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales;
            Clostridiaceae; Clostridium.
REFERENCE   1  (bases 1 to 3208157)
  AUTHORS   Jaakkola,K., Lahti,P., Virtanen,K., Lindstrom,M. and Korkeala,H.
  TITLE     Comparative genome analysis and spore heat resistance assay reveal
            niche adaptation within Clostridium perfringens enterotoxin-carrying
            isolates
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3208157)
  AUTHORS   Korkeala,H. and Jaakkola,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2021) Department of Food Hygiene and Environmental
            Health, University of Helsinki, Agnes Sjoberginkatu 2, Helsinki
            000066, Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 104x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020138715.1-RS_2024_11_27
            Annotation Date                   :: 11/27/2024 04:03:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,042
            CDSs (total)                      :: 2,914
            Genes (coding)                    :: 2,876
            CDSs (with protein)               :: 2,876
            Genes (RNA)                       :: 128
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 94
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 12 of 38
            Pseudo Genes (incomplete)         :: 22 of 38
            Pseudo Genes (internal stop)      :: 10 of 38
            Pseudo Genes (multiple problems)  :: 5 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:22:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2384141
            Orig. end                         :: 2405725
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP075970.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21584
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="4"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21584
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21584
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11584](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11584)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    128..145
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(1157..2599)
                     /locus_tag="KLF29_RS10545"
                     /old_locus_tag="KLF29_10495"
     CDS             complement(1157..2599)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451561.1"
                     /locus_tag="KLF29_RS10545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10495"
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="WP_224380001.1"
                     /sec_met_domain="PF04055 (E-value: 5.5e-20, bitscore: 69.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFIS
                     ENMVKISEGDNSFSYEFKEGYGFKTELKKGIFKFLSETLKDEYPWGTLVGIRPSKIALS
                     LIREGKSEEEIIKYFEDNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFCPTR
                     CLYCSFAANPIAGCKKDVEPYLEALSKEISAISDYVSKRGLKIETVYFGGGTPTSVNNE
                     QFEVLMKHIYDSFVNNKGIKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKT
                     LKSIGRGHLTEDVVDKFNLARSLDFDNINMDIIIGLPNEDISEVSKTCSMIKGLNPDSL
                     TIHGMSIKRASRLHENLVLHNTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMV
                     GNMENVGYSKDNKECIYNIQMIEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVK
                     EYVKRIEEMVEGKIELLDTLYK"
     gene            complement(2589..3209)
                     /locus_tag="KLF29_RS10550"
                     /old_locus_tag="KLF29_10500"
     CDS             complement(2589..3209)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003455108.1"
                     /locus_tag="KLF29_RS10550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10500"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_011010693.1"
                     /transl_table=11
                     /translation="MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESL
                     DAKPKMILLTHGHFDHVGAVQKLAEKYKIPFYIDKKDEDMIERNVDVFGKLPKADGYLK
                     DGDTLKFSDNYEIKCLETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHATLL
                     KSINDKLVPLGDDIVVYPGHGPSSTIKHERQRNPFLAGDFYVY"
     gene            complement(3369..3818)
                     /gene="dtd"
                     /locus_tag="KLF29_RS10555"
                     /old_locus_tag="KLF29_10505"
     CDS             complement(3369..3818)
                     /EC_number="3.1.1.96"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dtd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451157.1"
                     /locus_tag="KLF29_RS10555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10505"
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="WP_003451157.1"
                     /transl_table=11
                     /translation="MRVVVQRVNKSSVKVDNEIVGSINKGFNVLVGIGKEDTIEDLKYM
                     KDKVLNLRVFEDEEDKMNLSLKDVCGELLLISQFTLYGDCRKGRRPNFMNALGGDEAKK
                     LFDEFVSMCREEGIKVETGVFGAHMVVDIENDGPVTLILDSKKNF"
     gene            complement(3833..6013)
                     /locus_tag="KLF29_RS10560"
                     /old_locus_tag="KLF29_10510"
     CDS             complement(3833..6013)
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451435.1"
                     /locus_tag="KLF29_RS10560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10510"
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_224380002.1"
                     /transl_table=11
                     /translation="MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYIT
                     HPISVAMILADMGMDTNTIVAGLLHDVIEDTDYTYEDISNIFNVEVANLVDGVTKLGKI
                     KYKSKEEQQADNVRKMLLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQETLDI
                     FAPLAHRLGISKIKWELEDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENL
                     DKANIDSDIEGRPKHFYSIYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTI
                     YKPIPGRFKDYIAMPKPNMYQSLHTTVIGSEGKTFEIQIRTFEMHRTAEYGIAAHWKYK
                     SGINGTDSKDMTFENKLTWLRDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVI
                     NLPAGATPIDFAYKIHTDIGNKCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNID
                     WLNIANSNQARSKIKQWLRKARREENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLK
                     RYHLNNVEEIYVAIGEGELLSSTVISKLKENIVKQVAEEELNKNIEEQIAKTERQIKKK
                     QNYGVTVKGLNNIMVRFARCCNPVPGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQTEK
                     VVDVSWGTEKGAAYVAELEVKAEDRMCLLSDVMLVITDSNLSLLSLNAKSGRNGVANIN
                     IQVKIDNIEQLKELMKKIRRLQGILDVYRVNK"
     gene            complement(6165..6683)
                     /locus_tag="KLF29_RS10565"
                     /old_locus_tag="KLF29_10515"
     CDS             complement(6165..6683)
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006168 - adenine salvage [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012424264.1"
                     /locus_tag="KLF29_RS10565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10515"
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_003451591.1"
                     /transl_table=11
                     /translation="MSLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFK
                     DKNIDVVVGPEARGFIFGVPVAYALGVGFIPVRKPGKLPGDTVRVEYDLEYGKDALEIH
                     KDAIKPGMRVAIVDDLLATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLKGYE
                     VTSLVDYDV"
     gene            complement(6728..7582)
                     /locus_tag="KLF29_RS10570"
                     /old_locus_tag="KLF29_10520"
     CDS             complement(6728..7582)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010695.1"
                     /locus_tag="KLF29_RS10570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10520"
                     /product="DHH family phosphoesterase"
                     /protein_id="WP_011010695.1"
                     /transl_table=11
                     /translation="MQKAWKNIYCTNYISGYSPFNIKNMNKAIERLASAINNREKIVIY
                     GGCDLDSICAISSLMLILKYLNADVEYCVSSEHEEKNYDIDEYTLREDIAFLGAELLIT
                     VGCGLKNKEVENLCNRFNIDLIIMENKRTKCIYDSTYINPSEEKCSYRYKDLTNSGLTF
                     KLMQAIAIYYNMKRINKYLDLILIGSVSKNVKNKGENGIILKEGIQYLRYTNSIGLNAI
                     KSFFNISDINIDSINKIVNEITPREGAISKKDNAKIVVELLTTNDKDRAEQITKYIYNE
                     KIR"
     gene            complement(7782..8651)
                     /gene="secF"
                     /locus_tag="KLF29_RS10575"
                     /old_locus_tag="KLF29_10525"
     CDS             complement(7782..8651)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591004.1"
                     /locus_tag="KLF29_RS10575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10525"
                     /product="protein translocase subunit SecF"
                     /protein_id="WP_003451195.1"
                     /transl_table=11
                     /translation="MLKIVEKKKIWFTISILIIVIGFGFMFTKGMNFGIDFRGGTQVVI
                     NMGTDFNKTDVDKIVDEYSKDAVTNQVNGTELQIKAKELNSSQVNDIFKALKEKYDLKD
                     DALVSQNEIGASVGRDLTTNAIVALVIAVIGMLIYVVIRFEFSFGIAAIIALLHDVLIT
                     ISVYAVFGITINTPFIAAILTIVGYSINDTIVIFDRIRENRKKLRGKSVEEIADMSITQ
                     TMSRSINTTLTTLITIVCVYIFVPTVRDFAFPLIVGIASGACSSIFIASPIWCILANRQ
                     KNKKARNK"
     gene            complement(8644..9903)
                     /gene="secD"
                     /locus_tag="KLF29_RS10580"
                     /old_locus_tag="KLF29_10530"
     CDS             complement(8644..9903)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454737.1"
                     /locus_tag="KLF29_RS10580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10530"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_003451081.1"
                     /transl_table=11
                     /translation="MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITK
                     GLDLQGGVSVLMEIQSNDVTVDQLNTTKELLSLRVNKVGVSETVVTTEGNNRIRIDIPG
                     QYDSGTIVDSLQKTGELTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEEGKQ
                     KFAEATKKYKGQKIAIKMDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGA
                     LPVPVKAVSVETVGAQLGANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYI
                     LLVLYIFALVGVTLTLPGIAAFLLTVGMAVDANVLIFERIKEELGNGRSITSAMKIGFS
                     NALRSIMDSNITTLIAGLVLYFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFN
                     MGILNKPSMFGRIKGGRHNA"
     gene            complement(10001..11374)
                     /gene="scfB"
                     /locus_tag="KLF29_RS10585"
                     /old_locus_tag="KLF29_10535"
     CDS             complement(10001..11374)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591005.1"
                     /locus_tag="KLF29_RS10585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10535"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_003451573.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 2.2e-26,
                     bitscore: 89.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.4e-84, bitscore:
                     280.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.5e-13, bitscore: 46.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.8e-13, bitscore: 47.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.8e-21, bitscore:
                     73.7, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.8e-06, bitscore: 25.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALIHKFMQGGEYYVVDVNSGSVHIVDDLIYNMIDNDNKLSSKES
                     LIEKLKDKYPVEEIEEAYEDLLQLVEEDALYSGDLYEEVAKESDKAPSYIKALCLNVVH
                     DCNLRCKYCFADEGEYKGCRKPMSAEVGKKAIDFVLANSGGIKNIEVDLFGGEPLMVFD
                     TIKEIIDYGKKRGQEVGKNVRFTMTTNATLLNDERIDYIDKNIGNIILSIDGRKEVNDA
                     VRIRVDGSGSYDRILPNIKKMVEKRDPSKQYYARGTFTRNNTDFFQDVMALANEGFTEI
                     SIEPVVLPDEHELSLRREDLPTIFGEYDKLYNEMVRRLEEGDNIFKFYHFNIDLNGGPC
                     VYKRIAGCGAGHEYIAVTPDGEIYPCHQFVGNTDFLLGNIYDGEIRKDLSTEFKQAHIY
                     NKPKCKECWARFYCSGGCQANNFNFNGDIHVPYEVGCEMQKKRIECAIALKSKTMDAE"
     aSDomain        complement(11072..11371)
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KLF29_RS10585_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="2.20E-28"
                     /identifier="RREFam024.1"
                     /label="KLF29_RS10585"
                     /locus_tag="KLF29_RS10585"
                     /protein_end="101"
                     /protein_start="1"
                     /score="89.4"
                     /tool="antismash"
                     /translation="ALIHKFMQGGEYYVVDVNSGSVHIVDDLIYNMIDNDNKLSSKESL
                     IEKLKDKYPVEEIEEAYEDLLQLVEEDALYSGDLYEEVAKESDKAPSYIKALCLN"
     gene            complement(11444..11584)
                     /gene="scfA"
                     /locus_tag="KLF29_RS10590"
                     /old_locus_tag="KLF29_10540"
     CDS             complement(11444..11584)
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003357718.1"
                     /locus_tag="KLF29_RS10590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10540"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_003451489.1"
                     /sec_met_domain="TIGR03973 (E-value: 8e-21, bitscore: 71.0,
                     seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.1e-17, bitscore: 61.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIKTVNKSSLKKSLCKPADCRECANSCQSACKTSATVANLACE
                     N"
     gene            complement(11780..12049)
                     /gene="yajC"
                     /locus_tag="KLF29_RS10595"
                     /old_locus_tag="KLF29_10545"
     CDS             complement(11780..12049)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451165.1"
                     /locus_tag="KLF29_RS10595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10545"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_003451165.1"
                     /transl_table=11
                     /translation="MNFQQIATMVLPFILMFGVFYFLLILPEKKRKKKYDAMIDELKVN
                     DKIITRGGIIGRIVKLKDDSVIIETTQDRTKIEFSKQGISSKID"
     gene            complement(12088..13230)
                     /gene="tgt"
                     /locus_tag="KLF29_RS10600"
                     /old_locus_tag="KLF29_10550"
     CDS             complement(12088..13230)
                     /EC_number="2.4.2.29"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) bTGT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003461963.1"
                     /locus_tag="KLF29_RS10600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10550"
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="WP_003451459.1"
                     /sec_met_domain="bTGT (E-value: 5.9e-162, bitscore: 536.1,
                     seeds: 1816, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKRYTLLKKDGKARRGEFVTPHGTIQTPVFMNVGTLAAIKGAV
                     SSMDLKEIGCQVELSNTYHLHLRPGDKIVKQMGGLHNFMNWDRPILTDSGGFQVFSLAG
                     MRKIKEEGVYFNSHIDGRKIFMGPEESMQIQSNLGSTIAMAFDECIPNPSTREYVEKSV
                     ARTTRWLERCKKEMDRLNSLDDTVNKEQMLFGINQGGVYEDIRIEHAKTIREMDLDGYA
                     IGGLAVGETHEEMYRVIDAVVPHLPEDKPIYLMGVGLPSNILEAVERGVDFFDCVLPAR
                     NGRHGHVFTKEGKINLMNAKFELDARPIDEGCQCPACKNYTRAYIRHLFKAKEMLAMRL
                     CVLHNLYFYNKLMEDIRDAIDGGYFAEFKAKKLEEWNGRA"
     gene            complement(13254..14279)
                     /gene="queA"
                     /locus_tag="KLF29_RS10605"
                     /old_locus_tag="KLF29_10555"
     CDS             complement(13254..14279)
                     /EC_number="2.4.99.17"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="queA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451606.1"
                     /locus_tag="KLF29_RS10605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10555"
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="WP_011592785.1"
                     /transl_table=11
                     /translation="MKVSDFYFELPEELIAQYPLEKRDSSRLMVLDKKTGEIEHRKFHD
                     ILEYLNEGDTLVLNNTRVLPARLIGEKEETGGKIEFLLLKRIEGDKWECLAKPGRKAKV
                     GTVFTFGEGKLKAIVREIGEEGNRIIEFKYDGIFEQVLDELGQMPLPPYIHEKLEDKER
                     YQTVYSKEKGSAAAPTAGLHFTEDLLKEIKDKGVNIAYLTLHVGLGTFRPVKVDDVNNH
                     VMHSEYYHLDKENAELINKTKEAGKRVIAVGTTSSRTLETIGDENGRVREQSGWTDIFI
                     YPGYKFKIVDNLITNFHLPESTLIMLVSALAGQDNIMNAYNTAVKEKYRFFSFGDSMFI
                     K"
     gene            complement(14301..15341)
                     /gene="ruvB"
                     /locus_tag="KLF29_RS10610"
                     /old_locus_tag="KLF29_10560"
     CDS             complement(14301..15341)
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003451099.1"
                     /locus_tag="KLF29_RS10610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10560"
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="WP_003451099.1"
                     /transl_table=11
                     /translation="MSERLVTSNEIGIDSTNEYSLRPEKINEYIGQDKVKERLNIFIKA
                     AQRREEALDHVILYGPPGLGKTTLANIIANEMGGNLKITSGPAIERAGDLAAILTTLNT
                     NDVLFIDEIHRLNRSVEEILYPAMEDYVLDIIIGKGAASKSIRLDLPKFTLIGATTRIG
                     MLSSPLRDRFGVLCSMEYYTDEQLKEIIIRSAEILGCHITEEGAFEIAKRSRGTPRIAN
                     RLLKRVRDFAEVLYDNEITEEAAKKSLEILEVDGEGFDRIDNKILEAIIDNFNGGPVGI
                     ETLAYFVGEELDTIEDVYEPYLLQKGFIVRTPRGRMATDKAYKHLGRVRFNESKIDSKQ
                     CTLFEK"
     gene            complement(15355..15960)
                     /gene="ruvA"
                     /locus_tag="KLF29_RS10615"
                     /old_locus_tag="KLF29_10565"
     CDS             complement(15355..15960)
                     /EC_number="3.6.4.12"
                     /GO_component="GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003473697.1"
                     /locus_tag="KLF29_RS10615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10565"
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="WP_003473697.1"
                     /transl_table=11
                     /translation="MYEYIRGQFQGISKDYVVIELNNIGYKIFTSGNTMSNMPKVGEEV
                     LLYLEQIVREDFIGLYGFTTREELEMFKLLLSINGVGAKAALSLLSISTVNNLKYAIMM
                     GDEKHITRAPGIGKKTAQRIILELKDKLKPDELTSEEGQLIEGINDNSDYSFNINETLS
                     ALMALGYTEKEAQKALEKVDKTLSIENMIKESLKLLMR"
     gene            complement(16188..16781)
                     /locus_tag="KLF29_RS10620"
                     /old_locus_tag="KLF29_10570"
     CDS             complement(16188..16781)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010701.1"
                     /locus_tag="KLF29_RS10620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10570"
                     /product="hypothetical protein"
                     /protein_id="WP_195390254.1"
                     /transl_table=11
                     /translation="MNFNNIKNNDKIKNLIFILLSIFIFASSYMITYFYNSRKIQQTNM
                     KVTEKKGELVLAENMDVIFTRRTLDDHVVVDYKTTIGEMVKNDEIKGENMDELISAVEK
                     DGYELVSSTSGEIIFLNDMGILEAGKYYIGEKDGYIAIFKAGEDGRPFIEKPEDVSTKK
                     IEDLPEVDRSKISNFEKKYDTREECEENITNYIS"
     gene            complement(17077..20613)
                     /locus_tag="KLF29_RS10625"
                     /old_locus_tag="KLF29_10575"
     CDS             complement(17077..20613)
                     /EC_number="3.1.3.5"
                     /EC_number="3.1.3.6"
                     /EC_number="3.1.4.16"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003478460.1"
                     /locus_tag="KLF29_RS10625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLF29_10575"
                     /product="multifunctional 2',3'-cyclic-nucleotide
                     2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase"
                     /protein_id="WP_195390255.1"
                     /transl_table=11
                     /translation="MLKKVRDKKFTALAVATSMIFGIATPLTTVKATENLAPENLEKKG
                     EEASLEKEGDVTIQILGTSDLHGRFMNYEYARNQKSDGGLNQISTLVNEARNENPNTIV
                     VDNGDTIQGNFNHLFKNGPNPMVMGMNAIGYDVFSLGNHEFNYGMDNLNDVVSQANDNL
                     DVLCANLYKDGKRVYEGYTTREIEGVEVALIGVVSPHIMKWDSENLKGYEAKNPAEEVG
                     FVIDEIENRPEGGADVYAVVSHVGLESEYGNGDSARAIAEMNPEVSAIVAGHSHTNVPE
                     EKINNAVISQPTSNGQMVSKIELTVRKNGEKVEVVDKKSKLLSTKGVAEDQKINDLLAD
                     FHNTAIADATAPVGEMVGGNLADKNEIKEIPQSLVEDQGITDFINEVQLYNSRKHLESK
                     NINPDEVYMVSGAALFSASSNLYEGNISKADISNIYRYDNKLYTIKTNGKQLKKYMEKN
                     AEYYNTYKDGDLTVSFNEDVRMYLYDMFDGISYEINISKEPGQRIENLKFEKDGKPVED
                     SDVVYLTVNDYRYNSGLAAGIMDQGEHEKIYDTNNDQISDMRDLIVDYIQNVKGGKITK
                     NVDNNWKITGNDWDSEQRELAVKLVNEGKIKIPVSEDGRTPNVKAVTWNDVLEALGTKE
                     VEIPIVTFNDFHGSLAESKSDVGAAKLVGEIKRVKEENPNTVVVTGGDIYQGSAMSNLL
                     KGEPVTAMLKEMGLEFSAVGNHEFDWGYEYIPDWAKAGEFDFLASNIYEKETGEPVEWA
                     KPYGVVEREGKKVGFIGLATPETAYKTKPDNVAHLEFKDPVEATKTWVDYLENEENVDA
                     VVVLSHLGSEQNRETGEITGEIVEVAEVPGVDAIISAHSHQKVEGKVNGVPVIQAYKNG
                     RNLGYVNLKFDYKDELVVTTKLDDISKRKDTLPVDKNMEDILAKFEADLAPIMNEKVAD
                     LSVDLPHDRDTGVSPMGATVAETMRRIVDADIAITNGGGVRAPLMAGTVTVGDMYTILP
                     FDNTLVTMEMKGSDIIKVLEHGIEPDNFGWGQHAGVKLWYTPGAERGEKITSVRLADGT
                     KLENDKYYTVVTNDFMAVGGDSYDFSAAKNVVDTNLVIRDEMANYWKENGIDPITDLAT
                     LLEDGEDTTVDSEKPENPENPGNPETPENPDNGENLPNTGMPFGTGAVAAMGTVLTIGG
                     LAVLRKKKNNAA"
     misc_feature    20707..20724
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 20.08"
                     /tool="antismash"
     misc_feature    21474..21488
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.44"
                     /tool="antismash"
ORIGIN
        1 tttagctcct attttattag catatttcat ttgagcttta acactctttc ctaagtgatc
       61 tatttcagcc ttaataccag cctttctaag attaaatgct aatttcatag cttcaagctt
      121 agcattgtct cccattgagc caatataaac ttcgcatcta acaggctcag gaatttctat
      181 tccttcttca tctaaaacta aaagaagtct ttctaaacct aatgcaaatc ccatagctgg
      241 agttttagga ccatctattt cttctactag ataatcatat cttcctccac cacaaactgt
      301 taatccattt tttataactt caaaaacagt tttactatag taatctaatc ctcttactat
      361 ttgtggatct atattatact ctattcccat aacatctaag taagctttta acttgctaaa
      421 gtgatcacta cactcttcgc agatgtaatc tagtattgaa ggagcttcct taactatttc
      481 cttacatctc ttttctttac agtctatgat tctcatagga ttcttttcaa atcttgtttt
      541 acaagtttca caaagattat catagttctc ttttaaatat tgttttaaag cttcattgaa
      601 ttttgctcta cattttggac atcctaaact gtttatattt aagcttaatc cttttattcc
      661 aaaatcctct gttaatgctc tcataactaa agataagatt tctgcatcaa tagaagcttc
      721 ttgtgaacca aaaacttcta ttccatattg atggaattct cttaatcttc ctttttgcat
      781 tttttcatat ctaaaacatg gagtaaaata gaacattttt gttggctgag catcagcata
      841 taaactattt tcaataaatg ctctaacagc tgtagctgtc ccctctggtt taagagttat
      901 acttcttcca cctttgtctt caaaagtata catttccttt tgaaccacgt cagtagtttc
      961 tccaactcct cttttgaaaa gttcagttgc ctcaaacata ggagttctga tctctctaat
     1021 tccatattca gctgatattt ttcttaactt ttcttctata taatgccatt tataagcgtc
     1081 attaggtaac atatcctttg tacccttttg agcttgtatc gccataaaca actcctccta
     1141 cataatatta aattttttat ttatataaag tatcaagtaa ttctatctta ccttcaacca
     1201 tttcctctat tctttttaca tattccttta catctttaac atttgcaaat ctttctatac
     1261 gatttttatc ttcttctaaa aacactacct tagaaacggc atctgctcct agtgcaatta
     1321 tagtttgctt atcttcaatc atttgaatat tgtagataca ttccttgtta tcttttgaat
     1381 atcctacatt ctccatatta ccaaccatat ttttttgtct atacatataa tatggatgca
     1441 tatttagttc tctacctaaa actttactca tctcatacat cttattaaga tttttttgct
     1501 ctgcaatagt tatagtatta tgtaaaacta aattttcatg aagtcttgat gctcttttaa
     1561 tagacatccc atgaatagtt aaactatctg gattaagccc ctttatcata gagcatgttt
     1621 tagaaacctc tgaaatatct tcatttggaa gacctattat aatatccata tttatgttat
     1681 caaagtctag gcttcttgcc aaattgaatt tatccactac atcctctgtt aaatgccctc
     1741 tacctattga tttcaaggtt ttatcgttca tactttgagg atttatagat attctagata
     1801 cttcatatct cttcatagtt tttaattttt cttcagttat agaatcaggt cttccacatt
     1861 caacagtgaa ctcctttatt cctttattat taacgaaact atcatatata tgtttcatta
     1921 atacttcaaa ctgttcatta tttactgatg ttggagtacc tccaccaaaa taaacagttt
     1981 ctatctttaa gcctctcttt gatacataat cacttatagc tgaaatttct ttgcttaaag
     2041 cttctaaata aggctcaaca tctttcttgc atccagctat aggatttgct gcaaaggaac
     2101 aataaaggca tcttgtagga caaaaaggca taccaacata tatacttatg tttttttcct
     2161 ctttgtttac aaaactttct tctctttctg caacttctat gcaaagctta gctttttctt
     2221 ccctagccat ataattatct tcaaaatatt ttattatctc ttcctcagat tttccttctc
     2281 ttattagaga taatgctatt ttacttggtc ttattccaac taatgttccc caaggatatt
     2341 catccttaag agtttcagat aaaaatttga atattccctt tttaagttca gttttaaatc
     2401 cgtatccttc tttgaattca taagaaaaac tattgtctcc ctctgaaatt ttaaccatat
     2461 tttcagatat aaagacatca tagtctctct cttcatcttc atttacaaac tttaattcct
     2521 taaaagtata gaatatatta aacatttgat aaacgtcata tctatacttt aagtcattaa
     2581 gatatatttt aatatacata aaaatctcct gctaaaaatg ggtttctttg tctttcgtgt
     2641 ttaatagttg aacttggtcc gtgtcctgga tatactacta tatcatcacc taatggtacc
     2701 agtttatcat ttatactctt aagaagagta gcatgattac ccccttcaaa atcacttctt
     2761 ccaattgatt ctctaaatag agtatctcct gtaaaaagac aattatctat taagaagcat
     2821 aatcctcctg gtgtatgtcc tggtgtctct agacatttta tttcataatt atctgagaac
     2881 ttaagagtat ctccatcttt taaatatcca tctgcctttg gaagttttcc aaaaacatca
     2941 acatttcttt ctatcatatc ttcatctttt ttatctatat aaaaaggtat tttatatttt
     3001 tctgcaagtt tttgcacagc tccaacatga tcaaaatgtc catgagttaa taatatcatt
     3061 tttggttttg catctaaaga ttctattaca ttttcaattc ttgatgcttc ttcacctgga
     3121 tctaccatta tacaatcctt agtttcttca tctataacaa cataacaatt agcttgatac
     3181 attcctactg gaattgtttt tattaacata tcaatccctc ctaaaaaatg aagtttaatt
     3241 tatattttta accgaattta taggagtcta acttattaag ctaaactcct ataaaaactt
     3301 tcaatgttta acttttctaa aagcctatat ttattataat gctttataca caaaatagta
     3361 atatttgttt agaaattctt tttgctatct aaaattaaag ttacaggccc atcattttct
     3421 atgtcaacta ccatatgggc accaaagact ccagtttcaa cttttatgcc ctcttctctg
     3481 cacatgctta caaactcatc aaaaagtttc ttagcttcat cccctccaag agcattcatg
     3541 aaatttggtc ttcttccctt tctacagtct ccataaaggg taaattgcga tataagaagt
     3601 agttctccac aaacatcctt taaagataaa ttcattttat cttcttcatc ttcaaaaact
     3661 cttaagttta agaccttatc tttcatatat tttaagtctt caatagtatc ctctttgcca
     3721 attccaacta atacattaaa gcctttattt atacttccaa ctatctcatt atccacttta
     3781 acagaggatt tattcactct ttgaactaca actctcacga ttatgccccc ttttatttat
     3841 ttactctata aacgtctaat attccttgta gtcttcttat tttcttcatt aattctttta
     3901 attgttctat attatcaatt tttacttgaa tatttatatt tgctactcca tttctacctg
     3961 atttagcatt taaagaaagt aggctaagat tagagtcagt tataactaac ataacatcag
     4021 ataataaaca cattctatct tctgctttaa cctcaagttc agcaacatat gcagctcctt
     4081 tttcagttcc ccaactaaca tctacaactt tctctgtctg tttttctact atagctttaa
     4141 aattagaaca gtcttttcta tgtacagaaa ctcctcttcc cttagttata tacccagcta
     4201 tatcatctcc aggtacagga ttacaacacc ttgcaaatct aaccattata ttatttaatc
     4261 ccttaacagt tactccatag ttttgttttt tctttatttg tctttcagtt ttagctattt
     4321 gttcttcaat attcttattt aattcctctt cggcaacctg ttttacaata ttctctttaa
     4381 gcttagatat tacagtagat gaaagtaact ctccttctcc tatagctaca tatatttctt
     4441 caacattatt taaatgatat ctctttaata atttatcata taatggccct ttggaaagat
     4501 ctgaaaatac taaggattgc tttttacatt ccttatcaag catttccttt cctctttcta
     4561 aattctcttc tcttcttgct tttctaagcc actgctttat tttacttcta gcttgattgc
     4621 tattagctat atttaaccag tctatattag gtcctctaga tgatgaggat gttaatatct
     4681 ctactatttc cccagtttta agcttgtaat ctagagttac tatctttccg tttactttag
     4741 ctcctacgca tttatttcct atatctgtat gaatcttata tgcaaagtct atgggagttg
     4801 ctcccgctgg caaatttata actactccct taggagtaaa tacaaatatt tcatctgaga
     4861 ataagtcaag tttaaaccct tccataaact cagttgcatc aacagcttcc ttttgccact
     4921 caagtatatc tctaagccat gttaacttat tttcaaaagt catatctttt gaatcagtgc
     4981 cattaatacc actcttatat ttccaatgag ctgctattcc atactcagcc gttctatgca
     5041 tttcaaaagt tcttatttga atttcaaaag tctttccttc gcttcctatt actgttgtat
     5101 gtaaagattg atacatatta ggttttggca ttgctatata atctttaaat ctacctggta
     5161 ttggcttata aatagtgtgt actataccta gtactgcata gcaatcttta actgtattaa
     5221 ctaaaatcct tatagctgtt aaatcaaaga tttgttctat gctcttatgt ttattcacca
     5281 tttttctata tatactgtag aaatgttttg gtcttccttc tatatcgcta tctatattag
     5341 ctttgtctaa attttctttt agctctttaa ttatacgaga aataaatttt tctctctcca
     5401 cccttttttc agctatcata tttactaagt cataatattc ttctgggtga atatatctta
     5461 aacacaaatc ttctaactcc cactttattt tagatatacc caatctatga gctaaaggtg
     5521 caaatatatc taaagtttct tgggcttttt tcttttgttt ttcaggcttc atatatttaa
     5581 gtgttctcat attatgaagt ctatctgcta gttttattat tataaccctt atgtctttag
     5641 ccattgctaa aagcattttt cttacattgt cagcttgttg ttcttctttg cttttatatt
     5701 ttatttttcc aagcttagta actccatcga ctaaattagc tacttcaaca ttaaaaatat
     5761 tgcttatatc ttcataagta taatccgtat cctctattac atcatgaaga agtcctgcaa
     5821 ctatagtatt tgtatccatt cccatatcag ctaatatcat agctacacta ataggatgag
     5881 ttatgtatgg ttctcctgat tctctttttt gttctttatg tgcttcaaaa gctaaatcat
     5941 atgctttttt aactaaatct atatcaacat tattcccatt agcttttatt ttagaaatta
     6001 gttcttctaa catactggat tattctcccc tacttaaaat ttcttttaat atattatatt
     6061 attatataac aaaaaaataa aataaaccaa taataaaatt aatggctggt cgataaacca
     6121 gccattttta actctattat aattttttac aaaattaaag aattttaaac atcataatca
     6181 actaatgatg ttacttcgta tccttttaat ttatctcttc cttttaattc tgttaactca
     6241 atagtaaatg ctaatccagc aacttctcca ccagcttgtt ctactaattt agcaacagca
     6301 gctattgtac caccagtagc taaaagatcg tcaactatag caactctcat acctggtttt
     6361 atagcatctt tgtgtatttc taaagcatct tttccatact ctaaatcata ttctactcta
     6421 actgtgtccc ctggaagttt acctggcttt cttactggaa tgaatccaac acctaaagca
     6481 taggctacag gaactccaaa tataaatcct ctagcttctg gtccaactac aacgtcaata
     6541 ttcttatctt tgaagaattc tgccatttgg tcaactgaat ctcttaagcc ttctccatct
     6601 gctattagag tagttatatc tttaaaactt attcccttct taggaaaatc ttctataact
     6661 cttattttat cctttaaact cattactttc cctccaaaat caataaatat atataaattt
     6721 ttaattacta ccttattttt tcattataaa tatatttagt tatttgctcc gctctatcct
     6781 tatcatttgt agttaataac tccacaacta tcttcgcgtt atctttttta ctaatagcac
     6841 cttctcttgg agttatctca ttaactattt tattaatact atctatattt atatcactaa
     6901 tattaaagaa actcttaata gcattcaatc ctatactatt agtatatctt aaatattgaa
     6961 tgccttcctt taatattatt ccattttccc ctttattttt aacgttcttt gaaacactac
     7021 ctataagtat taaatctaaa tacttattta ttcttttcat gttataatat atagcaatag
     7081 cttgcattaa cttaaaagtt aaccccgaat tagtcaaatc cttatatcta tatgaacact
     7141 tttcttcact tgggtttata tatgttgaat catatatgca ttttgtgcgt ttattttcca
     7201 ttattattag atctatatta aatctattac agagattctc cacctcttta tttttaagtc
     7261 cacaacctac tgttattaaa agttctgcac ctaaaaaagc aatatcttcc cttaaagtat
     7321 attcatctat atcataattt ttttcttcat gttctgaact tacacaatat tcaacatcag
     7381 catttaaata ctttagtata agcattaaag atgatattgc acatatggaa tctaaatcac
     7441 atccaccata tataactatc ttttctctat tgttaattgc agatgctagt ctttctattg
     7501 ctttattcat atttttaatg ttaaaagggc tatacccaga tatgtaatta gtgcaatata
     7561 tgtttttcca agccttctgc ataatttaac tcctccataa aattaagaaa acaagtatat
     7621 tataatttaa aattaccttt ttgacaaata cttttcaaat aaatacgtat tcattagtca
     7681 tttttattac ttttctccta tttttcttaa aaaacaataa aaattctaat taaaataaaa
     7741 aaaatgctaa aagttataaa acttttagca tttatatact attacttatt tcttgccttt
     7801 ttattttttt gtctgttagc taaaatacac caaattggac ttgctataaa tattgaagaa
     7861 caagctcctg atgctatacc aactattaat ggaaaagcaa aatccctaac tgtaggaaca
     7921 aatatataaa cacaaactat agttattaaa gttgtaagtg ttgtatttat agatcttgac
     7981 attgtttgag ttatactcat gtctgcaatc tcttctacag attttcctct aagttttttt
     8041 ctattttctc ttattctatc aaatataact attgtatcat ttatagaata acctactatt
     8101 gtaagtatgg ccgctataaa tggagtattt attgttattc caaatacagc ataaacactt
     8161 atagttatta atacatcatg taatagagct attatagctg caataccaaa agagaattca
     8221 aatcttataa ctacgtatat aagcatacct attacggcta tcacaagagc tactatggca
     8281 tttgttgtta aatctcttcc tactgaagcc ccaatctcat tttgtgatac taaggcatca
     8341 tcttttaaat catatttttc tttaagagcc ttaaagatat cattaacttg agaactattt
     8401 aactcttttg cttttatttg aagttcagta ccattaactt gatttgtaac ggcatccttt
     8461 gaatattcat ctacaatttt atcaacatcg gttttattaa aatctgtacc catgtttatt
     8521 acaacctgag taccccctct aaagtcgatt ccaaagttca tacctttagt aaacataaat
     8581 ccaaaaccta taacaattat aagaattgat atagtaaacc atattttctt cttctctaca
     8641 attttaagca ttatgtctac ctccttttat acgaccaaac attgaaggct tatttaatat
     8701 tcccatgttg aatcctaaat tcataaagaa tcttgtcatt attatagcgg taaacatact
     8761 tattacaata cctattaata atgttaaagc aaatccttta actggtcctg atccaaagaa
     8821 gtataatact aaaccagcaa taagggttgt tatattagaa tccattattg atcttaaagc
     8881 attgctaaaa cctattttca tagctgatgt tatacttcta ccatttccaa gttcttcttt
     8941 gattctttca aatataagta cgttagcatc tactgccata cctactgtta ataagaaagc
     9001 tgctatacct ggtaaagtaa gagttactcc tactaatgca aatatataaa gcactaataa
     9061 tatataaaca cttagtgaca tacatgcaat gaatcctgga actctatagt atagtatcat
     9121 aaataagaat attatagcta cacctattgc tcctgctttc agagcatttg gaagagcatt
     9181 tgcacctaat tgagcaccta cagtctcaac tgaaactgcc ttaactggaa ctggtaatgc
     9241 accagcattt attattccag ataccttttc agcttcttcc attgatctat ttcctgaaat
     9301 aatagcttca ccattagaaa ttatgtcatt tactactgga tctgttaatg tttcattatc
     9361 catttttata gctatttttt ggcctttata tttttttgtt gcctcagcaa acttttgctt
     9421 accttcttcg ttaagctcta attttataac tggcttacct gtttgagggt ctatatatac
     9481 acttgacttt tcaacatctt tacctgttaa aataacatca tcctcaggcc ctacaaatgt
     9541 taactcccct gttttttgaa gagaatccac tatagttcct gaatcgtatt gtcctggaat
     9601 atcaattctt attctattat ttccctctgt cgttactaca gtttctgaaa ctccaacctt
     9661 attaaccctt aaagatagaa gttcctttgt tgtgtttaat tgatctactg ttacatcatt
     9721 actttggatt tccataagaa cagaaactcc accttgtaaa tccaatcctt tagttataac
     9781 ctcattaaac gttttaaatt gatagtcccc taatgtaaat cctttgaacc ctgctagagc
     9841 taaaaaactt atcactgcta tggagataaa aaataatatg aagctaccta attttgattt
     9901 catggttatc cccctctgta aaattttctc tgataaacta aattatatta atatgttgcc
     9961 atatagtcaa tatatggcaa caattattaa tattatattt ttattcagcg tccatagtct
    10021 ttgactttaa tgcaatagca cactcaattc ttttcttttg catttcacat ccaacttcat
    10081 aaggaacatg aatatcgcca ttaaagttaa agttattagc ttgacatcca ccactacagt
    10141 agaatctagc ccaacattct ttacattttg gtttattata tatatgagct tgtttaaatt
    10201 ctgttgaaag atcttttctg atttctccat catagatatt tcctagtaag aaatcagtat
    10261 ttccaacgaa ttggtgacat ggatatattt ctccatctgg agttacagca atatactcat
    10321 gacctgctcc acatcctgct attctcttat aaacacaagg accaccattt aaatcaatgt
    10381 taaagtgata gaatttgaat atgttatctc cctcttctaa tcttctcacc atttcattgt
    10441 ataatttatc atactctcca aagatagtcg gtaaatcttc tcttcttaaa gataattcat
    10501 gttcatctgg aagaacaact ggctctattg aaatctcagt aaatccttca ttagcaagag
    10561 ccattacatc ttggaagaag tcagtattat ttcttgtaaa tgttcctcta gcataatatt
    10621 gtttacttgg atctctcttt tcaaccattt tctttatgtt tggaagtatt ctatcataac
    10681 ttcctgaacc atcaactctt attctaacag catcgttaac ttcttttctt ccatctattg
    10741 aaagaattat atttccgatg tttttatcta tataatcgat tctttcatca tttaaaagag
    10801 ttgcattagt agtcatagta aatcttacat ttttgcctac ttcttgtcct cttttcttac
    10861 cataatctat tatttctttt atagtatcaa ataccattag tggttcccca ccaaataaat
    10921 caacttctat attctttatt ccacctgaat ttgctaatac aaaatcaata gcttttttac
    10981 caacttcagc actcattggt tttctacatc ctttgtattc tccctcatca gcgaaacaat
    11041 atttacatct taaattacag tcatgtacaa catttaagca tagagctttt atgtatgaag
    11101 gtgccttatc actttcttta gcaacctctt catataaatc tcctgagtat aaagcgtctt
    11161 cttctactaa ttgaagtaaa tcttcataag cctcttcaat ttcctcaact ggatatttat
    11221 cttttaactt ttcaattaaa gattccttac tacttaattt gttatcatta tctatcatat
    11281 tgtaaataag gtcatcaaca atatgaacac ttcctgagtt tacgtctact acgtaatact
    11341 ctccaccttg cataaattta tgaattaatg ccacaatatt tcctcctaac taagaactat
    11401 ggcagcaact ttaaaagtta ctgccactta agaattttta taattaattt tcacaagcta
    11461 agtttgctac tgtagctgat gttttacaag ctgattggca tgagttagca cactctctgc
    11521 aatctgctgg tttacataag ctctttttta agcttgactt gtttactgtt tttatacgct
    11581 tcatttactc ttcctccaat caaaactatc tttaatatta taccatgtta aggtttaatt
    11641 ttaaagttct ttttaaaaag ctaatttgat ttaccaccct tattctttca cattatactg
    11701 taaaattcaa tacctaaaat gaaaaaatag ttattttaat gcataaaata cattaaaaca
    11761 actatttctt taaattatac taatcaatct ttgaacttat gccttgtttt gaaaactcga
    11821 tctttgttct atcttgagta gtctctatta taacgctatc atcttttaat tttactattc
    11881 tacctatgat tccgcctcta gttatgatct tatcattaac ttttagctca tctatcatag
    11941 catcatattt tttctttctt ttcttttctg gtaagataag taagaaataa aatacaccaa
    12001 acattaaaat aaaaggtaat accattgttg ctatttgttg aaaattcata ctagccactc
    12061 ccttcttatt atgtaaattt tatattatta agctcttcca ttccactctt ctaatttttt
    12121 agctttgaat tctgcaaagt atccgccatc tatagcatct cttatatcct ccataagctt
    12181 attatagaag tatagattgt gaagaacaca taatctcata gctaacattt ctttagcctt
    12241 aaataagtgt cttatatatg ctcttgtgta atttttacat gcaggacatt gacatccttc
    12301 atctattggt ctagcatcta attcaaactt agcattcatt aagtttattt taccttcctt
    12361 agtgaaaaca tgaccatgtc ttccatttct agcaggtaaa acacaatcaa agaagtctac
    12421 tcctctttct actgcctcta atatatttga tggaagacca acccccatta aatatattgg
    12481 tttatcctct ggtaagtgag gaactacagc atctataact ctatacattt cttcatgagt
    12541 ttctccaact gctaatcctc caatagcata tccatctaaa tccatttctc ttatagtttt
    12601 agcatgttct attcttatat cttcataaac tccaccttgg ttaataccaa aaagcatttg
    12661 ctctttatta acagtgtcat ctaatgaatt taatctatcc atttcttttt tacatctttc
    12721 aagccatctt gttgttcttg caactgactt ttctacatat tctctagttg atgggtttgg
    12781 aatacattca tcaaaagcca tagctattgt tgaacctaaa ttactttgta tttgcatact
    12841 ttcttctggt cccatgaata tttttctacc atctatgtgt gagttaaaat aaactccctc
    12901 ttcttttatc tttctcattc ctgctaatga gaaaacttgg aatccacctg aatctgttaa
    12961 gattggtcta tcccaattca taaagttatg taagcctccc atttgcttta caatcttatc
    13021 tcctggtctt aaatgtaaat ggtatgtatt agaaagctct acttgacatc ctatttcttt
    13081 taaatccatt gaagaaacag caccttttat agctgctaaa gttcctacat tcataaaaac
    13141 aggagtttga attgtaccgt gaggagttac aaactcacct cttctagctt ttccgtcttt
    13201 ttttaaaaga gtatatcttt ttttagtcat gaaaaaagtc cttcctttgc tttttatttt
    13261 ataaacattg aatctccaaa tgagaagaat ctgtattttt cttttactgc ggtgttataa
    13321 gcattcatta tattatcttg accagctaaa gctgaaacaa gcattattaa agttgattca
    13381 ggtaaatgga agtttgtaat taaattatca actattttaa acttatatcc tggatatatg
    13441 aatatatctg tccatccact ttgttctcta actcttccat tttcatctcc aatagtttct
    13501 aaagttcttg aagatgttgt tcctacagca attactctct ttccagcttc cttagtttta
    13561 tttataagct ctgcattttc tttatctaaa tgataatatt ctgaatgcat aacatgatta
    13621 tttacatcat caacctttac tggtctaaat gtaccaagtc ctacatgtaa agttaaatat
    13681 gctatattaa cacctttatc tttaatttct tttaataaat cctcagtaaa atgtaatcca
    13741 gctgttggtg ctgctgctga tcccttttct ttagaataaa ctgtttgata tctttctttg
    13801 tcttctaact tttcatgtat ataaggtgga agtggcattt gtcctaattc atctagaact
    13861 tgttcaaata taccatcata cttaaactct attattctgt ttccttcttc accaatttct
    13921 ctaactatgg ctttaagttt accttctcca aaagtgaaaa ctgtacctac tttagccttt
    13981 cttcctggct tagctaaaca ctcccactta tctccttcta ttctctttaa aagaagaaat
    14041 tctattttac caccagtttc ttctttttct cctataagtc tagcaggtaa tactctagta
    14101 ttatttaaaa ctaaagtatc tccttcattt aaatactcta atatatcatg gaattttcta
    14161 tgttcaatct ctccagtttt tttatctaaa accattaatc ttgaagaatc tctcttttca
    14221 agtggatatt gagctataag ttcctctggt agctcaaaat aaaaatcact tactttcatt
    14281 ttaattacac cttctctatt ttatttttca aataacgtac actgtttaga atctatctta
    14341 gattcattaa atctaactct tcctaagtgt ttatatgctt tatctgttgc cattcttccc
    14401 cttggagttc taactataaa ccctttttgt agaagatatg gctcataaac atcttctata
    14461 gtatctaatt cctctccaac gaagtaagct aaggtttcta tccctactgg tcccccattg
    14521 aagttatcta ttatggcttc tagaatttta ttatcaattc tatcaaaacc ttctccatca
    14581 acttctaaaa tctctaagga tttttttgca gcctcttctg taatttcatt atcatataaa
    14641 acttctgcaa aatctctcac tctctttaaa agtctatttg ctattctagg agtacccctt
    14701 gaccttttag caatttcaaa ggccccttct tcagttatat ggcatcctaa aatttcagca
    14761 cttctaatta ttatttcctt taattgttca tcagtataat attccataga acataaaacc
    14821 ccaaatctat ctcttaaagg tgaactaagc ataccaattc tagttgtggc acctattaga
    14881 gtaaatttag gtaaatcgag tcttatggat ttactagcag cccccttacc aataattata
    14941 tctaaaacat aatcctccat ggcaggatat agtatttcct ctacacttct atttaatcta
    15001 tgtatctcat caataaacag aacatcatta gtgtttaagg ttgttaatat tgccgctaag
    15061 tctcctgctc tttcaatagc aggccctgat gttattttaa gatttccacc catttcattt
    15121 gctattatat tagctaatgt tgtctttcca agacctggtg gtccatataa aattacatgg
    15181 tctaaggctt cctctcttct ttgagcagct tttatgaata tgtttaatct ttctttaact
    15241 ttgtcttgcc ctatatattc atttattttc tctggtctca aactgtattc attagttgaa
    15301 tctattccaa tctcattaga ggtaactaat ctttcactca tttaattaca cctcctaacg
    15361 cattaaaagt tttaaagact cctttatcat attttctata gataatgtct tatcaacttt
    15421 ttctaaagct ttttgagctt ccttctctgt atatcctaat gccattaagg cacttaatgt
    15481 ttcatttata ttgaaactat aatcagaatt atcattaatt ccttctatta attgtccctc
    15541 ttcagaagta agttcatctg gttttaactt atccttaagc tctagaataa ttctttgagc
    15601 cgttttcttt cctattccag gtgctcttgt tatatgcttt tcatctccca tcattattgc
    15661 gtactttaaa ttattaacag tactaatgga taaaagtgat aaagcagctt ttgctcctac
    15721 cccatttatg gataataaaa gcttaaacat ttctaattct tctcttgttg taaatccata
    15781 tagacctatg aaatcttctc taacgatctg ctctagatat agaagaactt cctctcccac
    15841 ttttggcata ttagacattg tatttccaga tgtgaaaatt ttatatccta tattatttaa
    15901 ttctattaca acataatcct tacttatccc ttgaaattgg cctcttatat attcgtacat
    15961 atttaatgct cctatgtata ataagttctt taaatctata taatacttta acatgaagag
    16021 ggaatattat caatgaatta cacaaaattt actattcatt aaaaacactc taaactctct
    16081 attttcctag gtcatacttt catttaagta ataaaaaaag ccacatctta ctaagacata
    16141 gctattgatt atatatattt tttcaaatga taaatctact tacattttta acttatataa
    16201 tttgttatat tttcttcaca ttcttctctt gtatcatatt tcttttcaaa attacttatt
    16261 ttacttctat caacctctgg caaatcttct atcttctttg tgctaacatc ctctggcttt
    16321 tcaataaatg gtcttccatc ttcaccagcc ttaaatattg ctatgtatcc atctttttcg
    16381 cctatataat atttaccagc ttctaatatt cccatatcat ttaagaaaat tatttctcct
    16441 gaagttgatg aaactaattc atacccatct ttttctacag cagaaattaa ctcatccata
    16501 ttttctccct tgatttcatc atttttaacc atttctccaa tagtagtttt ataatcaact
    16561 acaacatggt catctaaagt tcttcttgta aatattacat ccatattctc agctaaaaca
    16621 agttcacctt ttttctctgt aaccttcata ttagtttgtt gaatttttct actattataa
    16681 aagtaagtta tcatataact gcttgcaaat ataaatatgc ttaaaagaat aaatattaag
    16741 tttttgattt tatcattatt ttttatatta ttaaaattca tatcatcacc tcattggtga
    16801 ttattaacat attttctctt tttatacaca cattttatgt ttttttattt tcaaacactt
    16861 ttaatattaa tattctatct aaatctccct agcttttgtt caataacctt cctatagtaa
    16921 ttaaattctt actatcttat ctaaaaaaat caaataaaaa tattcatggt taaactaaaa
    16981 aaatctctat ttttatatct aagatcaaaa ttagattaaa gtatatcata aaataaaaag
    17041 ggagtgatta aaattcactc ccaaaataat taattattat gcagcattat tctttttctt
    17101 tcttaataca gctagtccac caattgttaa tactgtaccc atagcagcca ctgctccagt
    17161 tccaaatggc atacctgtgt taggtaagtt ttcaccatta tcaggatttt ctggtgtttc
    17221 tgggttacct ggattttctg gattttcagg tttttctgaa tcaacagttg tatcttcacc
    17281 atcttctaat aaagtagcta aatcagttat aggatctatt ccattttctt tccaataatt
    17341 tgccatttca tctcttataa ctaagtttgt atccactaca tttttagcag ctgagaaatc
    17401 ataagaatct ccacctacag ccatgaaatc attagtaact actgtataat acttgtcatt
    17461 ttctaattta gttccatcag ctaatctaac agaagttatc ttttctcctc tttcagcccc
    17521 tggagtgtac caaagtttaa caccagcatg ttgtccccat ccaaagttat ctggttctat
    17581 tccatgctct aaaactttta ttatatctga acctttcatt tccattgtaa ctaaagtatt
    17641 gtcaaatgga agtattgtgt acatatctcc aacagtaact gttccagcca ttaatggggc
    17701 tcttactcct ccaccattag ttattgctat atcagcatca actattcttc tcatagtttc
    17761 agctacagta gcccccatag gacttactcc agtatctcta tcatgtggta aatctactga
    17821 taaatcagca actttttcat tcattatagg agctaaatca gcttcaaatt ttgctaatat
    17881 atcttccata ttcttatcaa ctggaagagt atcttttctc ttagaaatat cgtcaagttt
    17941 agttgtaact actaattcat ctttatagtc aaattttaag ttaacatatc ctaaatttct
    18001 accattttta tacgcttgta taactggtac tccattaact tttccttcaa ctttttggtg
    18061 actatgagct gatattatag catcaactcc tggtacttca gcaacttcaa caatctcacc
    18121 agttatttct ccagtctctc tattttgttc acttcctaaa tggcttaaaa caacaacggc
    18181 atctacattt tcttcatttt ctaaataatc tacccaagtc ttagttgctt ctacaggatc
    18241 tttaaattct aaatgagcaa cgttatctgg ttttgtcttg tatgcagttt caggagtagc
    18301 aagtcctata aatccaactt tctttccttc tctttcaaca acgccataag gcttagccca
    18361 ttcaactggt tctccagttt ctttttcata tatatttgat gctaagaaat caaattctcc
    18421 agctttagcc cagtctggta tatattcata tccccagtca aactcatggt taccaactgc
    18481 tgaaaattct aagcccattt ccttaagcat agcagtaact ggctcacctt ttaaaagatt
    18541 tgacatagca cttccttgat atatatctcc acctgtaaca actacagtat ttggattttc
    18601 ttcttttact ctctttattt ctccaactaa cttagctgct ccaacatcac tcttagattc
    18661 tgctaaagat ccatggaaat cgttgaaagt aactattggt atttcaactt ccttagttcc
    18721 taaagcttct aaaacatcat tccaagttac agcttttaca tttggagttc ttccatcttc
    18781 tgatacaggt atttttattt taccttcatt tacaagttta acagctaatt ctctttgttc
    18841 tgaatcccaa tcattacctg ttatcttcca gttattatca acgtttttag taatttttcc
    18901 accttttaca ttttgaatat aatcaactat taaatctctc atatctgata tttgatcatt
    18961 atttgtatca tatattttct catgctcacc ttggtccatt attccagcag ctaatccaga
    19021 attatatcta taatcattta ctgttaagta aactacatct gagtcttcaa ctggcttacc
    19081 atctttttca aactttaagt tttcaattct ttgacctggc tctttagata tatttatttc
    19141 ataacttatt ccatcaaaca tatcatataa atacattcta acatcttcat taaaagatac
    19201 tgttaaatcc ccatctttat aagtattata atactcagca tttttttcca tatacttttt
    19261 aagttgcttt ccatttgttt ttatagtata taatttatta tcatatctat aaatatttga
    19321 aatatctgct ttgcttatat ttccttcata taagtttgat gaagcactaa ataaagctgc
    19381 tccagaaacc atataaacct catctggatt tatattcttt gattctaaat gctttctact
    19441 attatataat tgaacttcat ttataaagtc agttatacct tgatcttcaa ctaatgattg
    19501 tggaatttct tttatttcat ttttatcagc aagatttcct ccaaccattt cgccaacagg
    19561 tgctgttgca tcagcaattg ctgtgttatg aaaatcagca agtaaatcat ttattttttg
    19621 atcctctgct acaccctttg tgcttaataa tttagacttt ttatctacaa cttctacttt
    19681 ttctccattt tttctaacag ttaattctat tttagaaacc atttgaccat tacttgtagg
    19741 ttggcttata actgcattat ttattttttc ttctggtaca ttagtatgac tatgtcctgc
    19801 aactatggca gatacctctg ggttcatttc agctatggct ctagcgctat ctccattacc
    19861 atattcactt tctaatccca cgtgtgaaac tactgcataa acatcagcgc caccctcagg
    19921 tctattttct atctcatcta ttacaaatcc aacttcttct gcaggatttt tagcctcata
    19981 tccttttaga ttttctgaat cccatttcat tatatgagga cttacaactc caattagagc
    20041 aacttcaacg ccttctattt ccctagttgt atatccttca taaactctct taccatcttt
    20101 ataaagattt gcacataata catctaaatt atcattagct tgacttacaa catcattaag
    20161 gttgtccatt ccatagttaa attcatgatt tcctaaagag aaaacatcat atcctatagc
    20221 attcattccc ataaccatag gattaggacc atttttaaat aagtgattga aatttccttg
    20281 tatagtatct ccattatcaa ccactattgt attaggattt tcatttctag cttcattaac
    20341 taatgtggat atttgattta atccaccatc agatttttga ttacgagcat actcataatt
    20401 cataaatcta ccatgaaggt ctgatgtacc taaaatctga atagttacat ctccttcttt
    20461 ttctaaacta gcttcttctc cttttttctc taggttttcc ggtgctaaat tttcagtagc
    20521 ctttacagta gttaacggtg ttgcaattcc aaagatcatt gaagtagcaa ctgctaatgc
    20581 tgtaaatttc ttatccctta cttttttaag catatttttc cccctcattt agtttactat
    20641 tgttataaaa gtaaatttta tacatatgta ttgtacatta tttggcgaat atttttcaat
    20701 cttttattgt taaatattcg ttaactttaa ttaacttttt tattttttta attcctagta
    20761 aattctatgc ttaaataaat ttaaatttaa taatcaatta atcttcttaa ataataaaag
    20821 cagtaaagaa attttcttta ctgctttttt agtcatttta aattaagctg catcattatg
    20881 tttctttttt agaattatgc taccgcctat agtagctaaa actcccattg ctgcaaaaac
    20941 ttcagatcca aaaggatttc ctgtgttagg taatttaatt aaatcatcct ttttattttc
    21001 ttcattattt gaattattat ctggattaga tatttcaggc ttatctgtat taatatcatc
    21061 tatagttgga tccattggct tatttgtatc tatagatggt ttttcttgtt caactggttt
    21121 gtttgaatct acagatggat tttctggttc tactggttta acagcttcac ccttatcttc
    21181 tccaggttca ataagagttg ctaagttagt tataggattt ataccatgat ttttccaata
    21241 atcacttatt ccttctctta aaactttatt agtatcttta atattcttag ctgctgagaa
    21301 atcatatcca tctccaccag ctgccataaa atcattagtc gctaatttat aatatttatt
    21361 tggatctagc ttacttccat ctaataatct tacagaagtt attctatttc caggttcagc
    21421 atctggatta taccagaact taagaccagc atgttgtccc catccaaaat ctttaggagc
    21481 aattccatgt tctaatactt taataatatc tgaacctttc atatccattg ttactatagt
    21541 attatcaaaa ggaagtatag tgtacatatc tcctactgtt atta
//
