LOCUS       NZ_CP082820            22991 bp    DNA     circular CON 26-OCT-2024
DEFINITION  Streptococcus pneumoniae strain SCAID PHRX1-2021 chromosome,
            complete genome.
ACCESSION   NZ_CP082820
VERSION     NZ_CP082820.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2098200)
  AUTHORS   Korotetskiy,I., Kerimzhanova,B., Jumagaziyeva,A., Myrzabayeva,A.,
            Shilov,S., Kuznetsova,T., Iskakbayeva,Z., Myrzagali,A., Reva,O.,
            Satylgankyzy,G., Korotetskaya,N., Zubenko,N. and Ivanova,L.
  TITLE     Clinical isolates genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2098200)
  AUTHORS   Korotetskiy,I., Kerimzhanova,B., Jumagaziyeva,A., Myrzabayeva,A.,
            Shilov,S., Kuznetsova,T., Iskakbayeva,Z., Myrzagali,A., Reva,O.,
            Satylgankyzy,G., Korotetskaya,N., Zubenko,N. and Ivanova,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2021) Virology and microbiology, Scientific Center
            for Anti-infectious Drugs (SCAID), 75A Al Farabi Ave., Almaty
            050060, Kazakhstan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: LR216047
            Genome Coverage                   :: 386x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019915285.1-RS_2024_10_26
            Annotation Date                   :: 10/26/2024 03:31:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,134
            CDSs (total)                      :: 2,061
            Genes (coding)                    :: 1,894
            CDSs (with protein)               :: 1,894
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 167
            CDSs (without protein)            :: 167
            Pseudo Genes (ambiguous residues) :: 0 of 167
            Pseudo Genes (frameshifted)       :: 87 of 167
            Pseudo Genes (incomplete)         :: 79 of 167
            Pseudo Genes (internal stop)      :: 50 of 167
            Pseudo Genes (multiple problems)  :: 42 of 167
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1762069
            Orig. end                         :: 1785060
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP082820.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="5"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12991](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(225..239)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            complement(782..2152)
                     /locus_tag="K8B76_RS08820"
                     /old_locus_tag="K8B76_08820"
     CDS             complement(782..2152)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="K8B76_RS08820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08820"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001036271.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGA
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSTFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAILATKVQS"
     gene            complement(2459..3625)
                     /gene="recA"
                     /locus_tag="K8B76_RS08825"
                     /old_locus_tag="K8B76_08825"
     CDS             complement(2459..3625)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="K8B76_RS08825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08825"
                     /product="recombinase RecA"
                     /protein_id="WP_001085462.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
     gene            complement(3680..4936)
                     /locus_tag="K8B76_RS08830"
                     /old_locus_tag="K8B76_08830"
     CDS             complement(3680..4936)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="K8B76_RS08830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08830"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_000642706.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     misc_feature    complement(4962..4975)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     misc_feature    complement(4963..4976)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     gene            complement(5021..6037)
                     /gene="brpA"
                     /locus_tag="K8B76_RS08835"
                     /old_locus_tag="K8B76_08835"
     CDS             complement(5021..6037)
                     /codon_start=1
                     /gene="brpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="K8B76_RS08835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08835"
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="WP_000239282.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     gene            complement(6045..6563)
                     /locus_tag="K8B76_RS08840"
                     /old_locus_tag="K8B76_08840"
     CDS             complement(6045..6563)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="K8B76_RS08840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08840"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000455537.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            complement(6553..6996)
                     /gene="tsaE"
                     /locus_tag="K8B76_RS08845"
                     /old_locus_tag="K8B76_08845"
     CDS             complement(6553..6996)
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="K8B76_RS08845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08845"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000288232.1"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     CDS             6987..7160
                     /gene="allorf_1769056_1769229"
                     /locus_tag="allorf_1769056_1769229"
                     /protein_id="allorf_1769056_1769229"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCTYSYYTKNFSFVSIFLLNLYSMKIMKSIKIKEQTRKLAVGCSK
                     YCFEVADRADIV"
     CDS_motif       6987..7058
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCTYSYYTKNFSFVSIFLLNLYSM"
                     /locus_tag="allorf_1769056_1769229_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7059..7160
                     /prepeptide="core"
                     /locus_tag="allorf_1769056_1769229_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="3718.4"
                     /monoisotopic_mass="3716.0"
                     /core_sequence="KIMKSIKIKEQTRKLAVGCSKYCFEVADRADIV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCTYSYYTKNFSFVSIFLLNLYSM"
                     /leader_location="[6986:7058](+)"
                     /alternative_weights="3736.5"
     gene            complement(7213..7833)
                     /locus_tag="K8B76_RS08850"
                     /old_locus_tag="K8B76_08850"
     CDS             complement(7213..7833)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="K8B76_RS08850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08850"
                     /product="hypothetical protein"
                     /protein_id="WP_084572333.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYIHDLLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIATLIFF"
     misc_feature    complement(8085..8102)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            complement(8139..9002)
                     /locus_tag="K8B76_RS08855"
                     /old_locus_tag="K8B76_08855"
     CDS             complement(8139..9002)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="K8B76_RS08855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08855"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093641.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEVKSNLSNFKHLSARLLDDRNYDDLEYLYKIEVERSTF
                     LTLEDRTYLEWIKSIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     gene            9194..9364
                     /locus_tag="K8B76_RS10880"
     CDS             9194..9364
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="K8B76_RS10880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    complement(9196..9211)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            9467..9691
                     /gene="pneA1"
                     /locus_tag="K8B76_RS08860"
                     /old_locus_tag="K8B76_08860"
     CDS             9467..9691
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="K8B76_RS08860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08860"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       9467..9553
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="K8B76_RS08860_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9554..9691
                     /prepeptide="core"
                     /locus_tag="K8B76_RS08860_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[9466:9553](+)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            9698..9886
                     /gene="pneA2"
                     /locus_tag="K8B76_RS08865"
                     /old_locus_tag="K8B76_08865"
     CDS             9698..9886
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="K8B76_RS08865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08865"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       9698..9772
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="K8B76_RS08865_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9773..9886
                     /prepeptide="core"
                     /locus_tag="K8B76_RS08865_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[9697:9772](+)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            10001..12991
                     /locus_tag="K8B76_RS08870"
                     /old_locus_tag="K8B76_08870"
     CDS             10001..12991
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="K8B76_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08870"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_000875573.1"
                     /sec_met_domain="DUF4135 (E-value: 5e-90, bitscore: 299.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.4e-51, bitscore:
                     170.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKNLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     misc_feature    13191..13204
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.84"
                     /tool="antismash"
     gene            13341..14045
                     /locus_tag="K8B76_RS08875"
                     /old_locus_tag="K8B76_08875"
     CDS             13341..14045
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="K8B76_RS08875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08875"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     gene            14026..14955
                     /locus_tag="K8B76_RS08880"
                     /old_locus_tag="K8B76_08880"
     CDS             14026..14955
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="K8B76_RS08880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08880"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            14952..17060
                     /locus_tag="K8B76_RS08885"
                     /old_locus_tag="K8B76_08885"
     CDS             14952..17060
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="K8B76_RS08885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08885"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701298.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.7e-37, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            17084..18823
                     /locus_tag="K8B76_RS08890"
                     /old_locus_tag="K8B76_08890"
     CDS             17084..18823
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="K8B76_RS08890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08890"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000699969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3e-37, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            18874..19641
                     /locus_tag="K8B76_RS08895"
                     /old_locus_tag="K8B76_08895"
     CDS             18874..19641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="K8B76_RS08895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08895"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_000078816.1"
                     /transl_table=11
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRISSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEIGVA
                     FLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            19643..20275
                     /locus_tag="K8B76_RS08900"
                     /old_locus_tag="K8B76_08900"
     CDS             19643..20275
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="K8B76_RS08900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08900"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000571422.1"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     CDS             complement(20990..21097)
                     /gene="allorf_1783059_1783166"
                     /locus_tag="allorf_1783059_1783166"
                     /protein_id="allorf_1783059_1783166"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTISLSRSVRCETKKTPAMRVCVEGYTKKTPNAIQ"
     CDS_motif       complement(21041..21097)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTISLSRSVRCETKKTPAM"
                     /locus_tag="allorf_1783059_1783166_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(20990..21040)
                     /prepeptide="core"
                     /locus_tag="allorf_1783059_1783166_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1771.0"
                     /monoisotopic_mass="1769.9"
                     /core_sequence="RVCVEGYTKKTPNAIQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTISLSRSVRCETKKTPAM"
                     /leader_location="[21040:21097](-)"
                     /alternative_weights="1789.1"
     gene            complement(21221..21634)
                     /gene="ndk"
                     /locus_tag="K8B76_RS08905"
                     /old_locus_tag="K8B76_08905"
     CDS             complement(21221..21634)
                     /EC_number="2.7.4.6"
                     /GO_function="GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ndk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /locus_tag="K8B76_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_08905"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_000438289.1"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     misc_feature    complement(21619..21632)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(21919..21930)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    complement(22734..22749)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    complement(22790..22802)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
ORIGIN
        1 aatactcgtg cgttttaatt ccagctaaac tccctgtatc aagcgttttc ggcaaacctg
       61 cttcatctgc tagattgcgt aagagttcga tataaaggcg gtagtccgtc atgaactctt
      121 ctttggttga atggctttca atcagttcaa ccgctgcata ggtctcagca ttccaaccgc
      181 ccccaacgtc ccaggcacca ttatcaacag gtcctacctg catgatgcaa ccgttcccaa
      241 caatgtgcga gaaaaaacct aattctgggt ctttccgcca gtgataatcc gcttcattct
      301 gtacggttga atgcggattc ccagttgagt gtgcgtgtac ttgcctatat ggttgcacgc
      361 cgacttgagg caaatctgtt cttaatttac tcacattaat ttccatattc tactccttat
      421 caattaaaac aactcatttt ttacaatcca gaaccagaaa ctcctttatt tctaccttac
      481 aaagaagaca atcttagtca cgattaggct tgtagataga acttcaaaac gcactatttt
      541 gacactgtaa ataggactga caaggtctgc attctatcta caataacacc ccagactaaa
      601 aagcttttca aaagtatatt tttacagtct ctatatgtcc ttttcataaa tactatactt
      661 tattatatca tataaaagaa gtcaaaagtc tgttaaacta ttttcaacac caaactaaag
      721 acgagaacac aagttttttc gattttcact agaggaaatg gattttattc agtaaatcca
      781 actaggattg cactttggtt gccaagattg ccttgccttc ttttatcaag ggatgacgga
      841 ataatgagaa gtacagttga actgtcatgg caacccagat aagaggttca caaaggataa
      901 cacccttata tcctgcccaa ggaataatca aaaccacaaa aacgattttt ccgattagtt
      961 caataaagct agaaactaga ggaaggatct tttgccccaa gccctgcaag caattgcgat
     1021 aaatcaacaa gaggctcaaa atgggataaa aggttgaact gatttgcaga tagagacttc
     1081 cattttctat caagtaacca tctgtcgaac tagccaagaa ggaaaccaaa gctggactgg
     1141 caaaaaagag gaaaatacaa acaaaaactg cccaggatat acttaaacga ctgccgattc
     1201 gaagaccttg aacaatacgg tcaggtcgct tagctcctag attctgagaa gcaaaggtcg
     1261 tcattgatgc agaaatagcg gtcataggaa gaagggcaaa ggtcataatg cgtcgagctg
     1321 ccgtctgggc actaataatc actgcaccaa atgtattaac agaaaactgt aaaatcacac
     1381 tgccgataga tacaattgaa ctcatcaagc ccatagccaa accttgctcc aagagatccg
     1441 cgtacaagct tttgtcccat ttgaaatgtt taaactgtgg caagagttct ggcacacttt
     1501 tacgaatata ataaaagcag agaaccgctg ataaaccttg cgaaataatg gtagcaagtc
     1561 ctgcggattg aactcccaga tgcaattgcg taataaaata gagatccaga accacattaa
     1621 ccaaggcaga gaaaatcaga aatcccaggg ctgctagact gtcaccaata gaccgcaaca
     1681 agcctgcaaa aagattataa gcaaagctga cacctacaca ggtcacaatc atagaaatat
     1741 attgataaga ttgaggaaga atttctgcag gagtatctaa gtattgcaag agaggataca
     1801 agccaagaaa gcccagcaac ataactagaa tgctcaaaag agcacctaaa atccaggtgg
     1861 ctgctactgc ttccttgatt ttagtgaaat tccgagcccc ataataacga gcaatgacaa
     1921 tccccatgcc attgccaaca ccaagtgtaa agcctacaat caggtcaaaa atcgctgtcg
     1981 tcgctcctac tgcagccaag gattcttgac caagaaatcg tccaacaatc aagacatcag
     2041 cagtgttata gagctgttga aaaatatttg atagcaagat tggaaaggtg aagcttaaga
     2101 gcgagggaag aatcggacca tgtatcaggt ccactgttcg ttttttattc ataaagctat
     2161 tatatcagct ttccagagga gcgacaagaa acagcaaact tatatatagc ggaatgaaat
     2221 aaggacagtc aaatcgattt ttaacaatgt tttagaagta gatgtgtact attctagttt
     2281 cgatctatta tagttggttg agtttggaat agtacgctgt agctgctaaa acatttctag
     2341 aaattaattt gactttccta ataaagttgt tcatatctta tttcaagcta ctatatataa
     2401 tctaaaaact tgaatcaaaa atcgaaaaag tagcggattt ctccactgct ttaacagctt
     2461 attcttcaat ttcgatttca agttcatcgc ctaagtcaag cggaacttct tcattcactg
     2521 cttcttcttt ctttggctca tcttttttgt tttcagtatc ttgttctgaa acttcttctc
     2581 catcaatcaa gccaaattta gaacggactt gcttatcaat ttcatcaaag atttctgggt
     2641 gctctgccaa gtatttctta gcattctcag aaccttgccc aattttttca tctttgtaag
     2701 aataccaagc ccctgctttt ttgataatat ccaaatcgct tgcaatcttc aaaagctcac
     2761 cagtcttaga aattccttct ccgtacataa tttcaactac ggcttcctta aacggtggag
     2821 ctaccttatt ttttacaacc ttaatcttag tttctttacc gacattggtt tctttttgat
     2881 caccagttcc cttaatttgt gtattaccac gaacatccaa gcggactgaa gcatagaatt
     2941 tcaaagcacg tccgcccggt gttgtttctg gatttccaaa catcactcca actttttcac
     3001 gcaattggtt gataaaaatg gcaattgttt tggttttatt gatagaggcg ccaagtttac
     3061 gcatggcctg gctcatcata cgagcctgca aaccaacatg gctatctccg atatctccat
     3121 caatttccgc acgaggaaca agggcagcaa ctgagtcgac tacgacaaga tcaactgcac
     3181 ctgagtcaat caattttccc gcaatctcaa gaccttgctc tcctgagtct ggttgagaca
     3241 agagcaattc gtcaatattg acaccaaggg ccgcagcata agctggatca agggcatgtt
     3301 ccgcatcgat aaaggcagca atcccacctt ctttttgcgc ttgtgcaact gcatgaaggg
     3361 caaccgttgt cttaccagat gactctgggc catagatttc gatgatacgt cccttaggat
     3421 aaccacctga gccaagggca atgtcaagag ctaaagaacc tgagctcatc acttgcacct
     3481 tttgctccgc acgttcaccc aaacgcatga ttgatccttt accaaagtct ttctcaatca
     3541 atttaagagc gtcattcaag gccttttcac gttctgcccc aaattttttt gaaatttctt
     3601 ctaatttttt tggttttttc gccattctat tctcctacat tctaatgatc ctcagaccta
     3661 tctactatta tatcaaaagt tagtcactta ataaagcctt gcgaactagg ttaaaggcat
     3721 gcataaccgc aatgtgacgt acatctgctc ggcttctgcc tccaatatta accttgataa
     3781 cctcagttcc ttgatcttgc gccaagccta tgaagactgt cccaactggg tgtccttcta
     3841 ggctatctgg tcctgccact ccagtcaaac taattccaaa atcagactgg gtcttgcttc
     3901 gtgcctgctc agccatcttc tgagctgtaa attcagacac cacaccatgt tcttccaaat
     3961 tcttggcagg aatatccaac atccttgatt tttcctccaa gctataggtc acaaaaccac
     4021 cctcaaatat acttgaaact ccagaaaaat tcgccacggt agcttggaaa agacctgccg
     4081 tcaaactctc tgcagccgcg atggttttcc cttgcctttt cagttcttct accacaatgc
     4141 tggctaaact agtttcttcc ccataaccat agcaaaagtc tcgtaaagaa attccttcga
     4201 aagtctggca gtccaagatt tgattttcca agatatccag cgcttgattc gcctcttctt
     4261 gactgctagc ctttgttgac agacgtagag tgacttctcc tgtcttggca taaggggcca
     4321 aggtaggatc gatctgatta tcaattaaat cagccaaaat cgtaaccaac tggctctcgc
     4381 caatcccaaa gaaacgaaga actcgggaat acagcttgct ccctgtcatc aacttgggta
     4441 gaagttggtt taagaccatg ggtttcaatt cacttggcgg acctggaagg acgacatagg
     4501 tcactccgtc tacttctaat tttcctccaa cagccagtcc tgtttcgttt ggcagtggaa
     4561 tcgctccttc tacaatttga gcttgtcttt cgttattcgg tgttcgggca tagtctggtc
     4621 gcagggcaaa aaagatatcc aacttctcct gagcctgagg atcaaagact aatgctttcc
     4681 ctaaaaattt agctagggtt tgtttggtta ggtcgtcctc agttggcccc aaaccgcctg
     4741 tcaaaatcac cagactgcta cgttgactgg caatctcaag caaagacaag agacgaactt
     4801 cattgtctcc tacagccgtc tgaaaatata catctacccc aatctcagct agtttttccg
     4861 acaaaaactg ggcattggtg ttgacaatct gtcctgtcaa aatctctgtt ccaacagcaa
     4921 tgatttctgc tttcatgttt cctcctacct atctattcgt atttttttga aaaaatcgca
     4981 ggaattttcc tacgattgat ttttttattt gtatcaaaag ttaattatct tcatcaccaa
     5041 caggtgctct gccaaataaa tcttcaaata aaaccgcatt ggtttcaagc tgagtaactt
     5101 cttcttgtcc caaagaacgt cggagtatat tttgcatttc caacatatgt gctctcgaaa
     5161 caatctggta agaaacacct tgaagtatct ctccttcacc ctgcaactgc tgagtttcaa
     5221 tggttttaaa tgaatcttta tagcctagca agttagggat actttttgca gacaaatcaa
     5281 tattggtctg catattgtca ctcaaagctt ttagaatctc ttgataatga ccaatgctat
     5341 ttaaactgag agctttttcc atgacttttt gaataacttc acgttgacgt ttttgacgac
     5401 cataatcccc ctcaggatct tggtaacgca ttcgtgcata gactagggct tcttctcccc
     5461 caatatgttg ctccccaaca ccgatagaaa tggtattaaa ttcttcttgg tcactgatag
     5521 aaattgggaa acctaggata ttattgactg taatacctcc tactgcatcc actaattttt
     5581 gcaaccctct catattgacc atcacatagc gatcaatatg gatattcatc attttttgaa
     5641 tggtttctat agcaagctct gctccaccat ctgcatatgc tgagttcagt ttcgcttcat
     5701 gagcctgacc attccctgat tcaatgcgcg tcagaatatc ccgctctaaa ctcatcattg
     5761 ttgttttttt cgttttagga ttcactgtca tcaagatcat gctatcactt ctaccgaccc
     5821 aagtttcagt tcgttcaaca tttccggtgt ccactcccat taacagaatg gttagaggtt
     5881 cagtcgcttc aataaccttg gtttcttcac cgattttttt ataggtttta gctaaggttt
     5941 ctgtcccttg ttgataaata gtataagcaa aaacacctac tcctactaca gttacagaaa
     6001 gtaaagctag caccattcca ataatttttt taaccatatt tctactaacc tatcagttta
     6061 cccatcaagt aaacatcgat aaatttccct tcttctatat atgccccacg ctcttggcta
     6121 ccttcaatga caaagccatg cttttgataa agatggactg ctgcttgatt acgagtttgg
     6181 acagtcagtt ggagacgacg cagaatgcca cttgcttgtg cccactctat cgcttcttct
     6241 agcaacaaac ttcccaagcc attattccaa tatctttttc caatcacaat gaagagatct
     6301 ccaatatgac ggactctctt acgctgatca gctgtaatat ttacaatacc agcaattttg
     6361 ccatttaaga atgcaagtaa ggttatctga ttgtccgaac tagcttgctt gttgaggaat
     6421 atttccatct cctcactagt caagagaata ccatctccgt ctaggctggt aaagtctgtc
     6481 tccaaactca cacgatttaa aaaggccact aattcagctg catctttggg ctctgcttcc
     6541 ctaatgagca attcatactc catattgaag ctcctctaac aatttctcag cacgcaaacc
     6601 ctttgcctga aaatttaaac ggcgtccatc tgcttctttt agaatttcca attctaaata
     6661 agcatctggc aaggcatctc ctaagagatt tccccactca ataacagtca cgccgccacc
     6721 aaagataaac tcatccaagt cgatagaatc agcatccccc tctatacgat aaacatctag
     6781 gtggtaaagc ggaagacgcc cctcatactc tcttacgata gtataggtgg gacttttaat
     6841 catttgagaa atctgtaaac ctttagcaag tcctttagta aaggtcgttt tacctgcgcc
     6901 cagttctcca gttaagatta aaacatcatt ctttgctaat agatgaccca aacgctcccc
     6961 taaggcttgc aactcttctt cattttttgt gtacatattc ttattatacc aaaaactttt
     7021 cttttgtgtc tattttcctg ctaaacttat actcaatgaa aatcatgaaa agcataaaaa
     7081 tcaaagagca aactaggaag ctagccgtag gctgctcaaa atactgtttt gaggttgcag
     7141 atagagctga catagtttga agagattttc gaagagtatt accatcataa catccataaa
     7201 aacaagcttt ctctaaaaga aaatgagcgt agcaatgacc aatacaagat ctcggaaaat
     7261 atgaccataa aaggaaactt ccttcttaac cgaatttggg acaagatagg ctgcaaagaa
     7321 caagcccagt ccaatataaa tcagaagtga gacaatggtc attggatttc ttaagaaaag
     7381 aagtgttgct aaaatagtca ccaacaccgt cttttttcta tctagcatag caagcaaatc
     7441 gtgtatgtat tttttcaagg gtaaaaaaat cagcaaatct agcccaaata gaaagaaaaa
     7501 ggatggcaac aaaaagtcaa ctaattcttg ctgcaacgta tttttaatga acaagttatc
     7561 tgacaagaca aggacagctc ctaataaatt aattaagagt aacatactgt aaaaaagctt
     7621 cactgacttc ttactggcta ggacactatg gacttcttgc ttacgggtat aaagataatt
     7681 tactccagca cagattcctg aaacgaagac catacttccg atgaaaaaag ctgtactttg
     7741 tttaaaggac aagatgcatt ctttccatag gaaacagcta ctcaaactga tttgaattaa
     7801 agctaacaaa aataagattc tcattgattt catcttttct ctcccttcct accaatcatt
     7861 atactaggag aaaagagaga actgtttcta atcttctcaa atgtcttttt aagacgctaa
     7921 acaaacacca gagactaata ctcaatgaaa atcaaagagc aaactaggaa gctagccaca
     7981 ggttgctcaa aacactgttt tgaggttgca ggtagagctg acgtggtttg aaaagattgt
     8041 cgaagaatat aaacttgaaa taaggctgat agtattcatt tcactatcag ccttacaggt
     8101 tatttaacgt ttcagaaaaa ctataatgtc aagattaact aaacagtatc taattccttc
     8161 aaataatttt ctatcttcat caacattaaa ggattgttat aaatcttaca taactctctt
     8221 gcttctatat aataattttt gacttgttct ctgtctagaa atttggctcc agcatttcct
     8281 acaagaataa gtagaggagc caattggtag cttgtctgtc tttgtttaca gagttcaatc
     8341 gtttcaagag cttcttggat ggcttcatta tatttttcct ttgatactag gtagtgagcg
     8401 tagttgtaac gaactctgat gtagccaaat aaaaactctt gatggtccaa attttttgtc
     8461 tgatacaact ctattaaatg agagtagttt gcctcatatt cttgttcacg acccactaag
     8521 gaatagaaat tagatagagt attcaacgcc tttaaataaa tcagagtatt tgaagagact
     8581 tttaataata tattttccaa tgacgaaatt gcctcacact tactgtcata ttgatagaag
     8641 tcaattatag atttaatcca ttcaaggtaa gttcggtctt ctaatgttag aaaagtgctt
     8701 cgttctacct ctattttata aagatattct aaatcgtcat aatttctgtc atctaatagg
     8761 cgagcagata gatgtttgaa attagagagg ttagacttaa cttcgatttg ttcattgaaa
     8821 aagtaatcca aagggacttc aagtcgttga gagagtttga ataacaagtc tgcggaggga
     8881 ataaaatgac ctctttcaat tttactaatc tggctttgtt cacaaattcc ttctgcaaga
     8941 gtttgttggg agagtctcaa ctcttttctt ttcaatctga atttctctgc gagtgtattc
     9001 attaaagata ataaaccttc ctatttgctt aatttcatta taaagttttt agttcaaaat
     9061 agcaagttaa aggaataaat aattctttat agtaataaac aaaaaaaaaa gttaaaaatt
     9121 acataaaaat acttgactaa ataaaatata tctgttagaa taaaaacaag gaaaaagaaa
     9181 ggggtttcat tgcatgagaa aaaaacgtgg aattaaaaaa ttagttacat ttgcattgct
     9241 aggtgttttt atgtttagta atacaattcc ttaccaacag tttattcaga agaataaaca
     9301 attggagatt cgagtgcaat cgcaaaagaa gtccaatggt cttgatgttg ggaaggcgga
     9361 ttaaaacccg atattttgca cgagaatgag agaattataa tttatctgaa aaaacgaaaa
     9421 atatagagca acttatttaa ctttttataa ggaggagtta ttacttatga ccaactttaa
     9481 ttcaaacgaa aaattttgtg gaaaaagttt aaaatcattg tctgctgatg aaatgagttt
     9541 aatttatggt gcatctgatg gtgcagagcc acgttggacg cctactccta ttattttgaa
     9601 atcagctgca gctagctcga aagtatgcat tagtgcagct gtttctggta ttggggggct
     9661 agttagctac aataatgatt gtttggggta aattaaaatg aaaaatgatt ttgtaatcgg
     9721 aaagagtttg aaagaattat ctcttgaaga aatgcaattg gtttatggtg gcacagatgg
     9781 tgctgaccct agatcaacaa ttatatgttc tgctacatta agttttattg catcatattt
     9841 ggggtcagct cagactcgtt gtggcaaaga caacaagaaa aaataaaata ttcaatttta
     9901 aaaataaaag ttgctcttta ttttcctctc tcgtaactaa taattttgag agaggttttt
     9961 tttaaaacaa tagtaagtcg tataggtttg aggtaagtaa atgaaatata aaattaaaaa
    10021 tgtgcataaa acattgttta ttaaggaaag atatcaaata ttatctgaac gaaatgataa
    10081 ttccttaaat aacttttcat taaataattg gcgttctaca atgtcaatta tttctgaaaa
    10141 aacttttgaa gaaatgttga aattaaataa ttacaataaa aaaatatttt ctaacactgt
    10201 gaactatgat tataccgagg aacagataag actatattca gaatatgcca aaaattcgga
    10261 atggtataaa tttgcggagg gttcatttga aatatttaga aaacatcccc aaagaattaa
    10321 ttttaagaaa gatttttcta gaattttgga accctttatt attaatttgc ttaaattaat
    10381 caataattat ctagagaata aagaatacga gtggattgac aagaatggaa atattttttc
    10441 ctctctagta ttttatttag aagatttaat ctatccttgg attgttaaac ctttggtttt
    10501 agagataaat tcattgcgtg aaaaaggttt acttgaaggg gaatcggagc agcaacggta
    10561 caaatatttt ataacattgt ttgacaagga agagaatata ttaaattttt ataacaaata
    10621 tcccgtttta ctgaggcaaa tatcggagtc ttgtcttcgg ttctatactt attttataga
    10681 aattttatca aatttagaaa atgattttag tgtgctagaa gaagaattag ggctaagggg
    10741 gaaattaaat gatataaaat ttggaaaggg tgatacacac agccaaggaa aaactgtttt
    10801 gatactcttc tttgatgacg cgaaaattgt ttacaagcct aaaaatttaa taatcaataa
    10861 ctcactaaat actattgctg agtatatccg aaaggttgat gaaaaaatta ggataagaat
    10921 acctcgaact attgcttatt cggatcacag ctatgaagaa tttattgatt atctacctct
    10981 agagcaaaag aaaaatttac ctgaatatta ttataatttt ggtgtgcttt tagcatttat
    11041 atatttattt aatgggagtg atatacattt tgaaaattta atttcctatg gagatatgcc
    11101 tgtaataata gactttgaaa caatgttaca gcaacctcta tttgatgata aaactggtca
    11161 gagtttgctg gataccctgt ttcacagggt gactcgaact ttgcttcttc caacagaggg
    11221 agtaaaaagg gaggatggtc ttgatgttga gatgagtgct cttacaggaa attttaagaa
    11281 ggatgctttt aatggtcaag ttttaattaa tttaaatact gataaggtaa agtttgatat
    11341 tgggaaaatt gattttgaag gtgggaaaaa cctgcctgtt cgggatggtg atatagaatt
    11401 tgataagtat ataaaagatt tcaaaaaagg ttttagggat ttttatctga tatttgaaga
    11461 gttaaataaa acagaagaat ttaaaatgct attaaaagca aacttgtatg gtttaaagac
    11521 aagggtactt tttagagaca caaatagcta tgcttcagta ctatcttttt tatatcatcc
    11581 tgatttttat gaagaaatgt tagatagaga aaaagcattg gaaaatctct ggagcaataa
    11641 gttttctaat caaggtattg tagcaagcga atgtgaacaa atgaggttat tagatattcc
    11701 gattttttat acagatacaa atatcaatga aatctacgat gattttggaa atcattttat
    11761 ttccctacat caattttctg gatatgacta ttttatgaaa tatttaccta ataataattt
    11821 ggaaaattta gaaaagcaac ttgatatcat tgaaatttat tttccaagct ttgatcagcg
    11881 aaaaaaagga tataaattaa acttatctaa tagaaaaaaa ctcccaaatg aaagtttagt
    11941 tactattctg cataatgaag tagaaaatat tgcagactct ttggttatta ataatattta
    12001 tgacgaatat ccaatttgga gtatacctgt taattttaaa ggttctaaat ggtgtcttga
    12061 acaaacgggt aatgatatgt ataggggtag agctggaata ttactgttta tgtactatgt
    12121 aaaattattg aaagataaat catcatatac tcaactgtac aataaaatgt tatctgcaat
    12181 tccgccatct gtttctttat ctaagaccac atttggttta actggggata taggatattt
    12241 cattgttcta tccattatag aggattacga tacaaatact ctcgcatgct taaattatat
    12301 aaagagtgtt ttaactgagc ttgaaaagac tgattttgca agtgtttcaa acaagtctga
    12361 ctatattaat ggtcttctac ctttaattaa tacactggta agatattata ggagaggaat
    12421 agagaaggaa cgtgttctaa ggctagtatt aagtttaggt gatacgctat ataatgatgt
    12481 aagcgagaga gataatagta attttggata tagttttggc catggactat caggtgtaat
    12541 ttttacatta aaaaatattt ataaagtgac aagacttaaa aaatataaag aattaatttt
    12601 acaactagtt cctagggaga aaatcaaaat tcattctttg aagtggtgta gtggagaatt
    12661 tgggacatta gttaatcatc cccaaagtgt tccagaggga attgtagcta gtttagataa
    12721 tgatacattt tgccatggaa gtatggccat aataaatttt tacatcgact acatgaaaga
    12781 aatggatact agtatggaat tggagtcttt attgtgtagt gttgtaatga ataaatcaaa
    12841 agaaggagag tatcgtatcg tccaaacaag caatttccca gatttttctt tgtatacagg
    12901 tgtgactggt attgcttata cttttttaag gtatatcgca ctgaatcaga atgacaaaaa
    12961 gatagttatc ccctcattac ttgaaatcta gcttaattta tagttttgtt tctaaaatag
    13021 aggtgtccac tcattaagca atataaaaat accaagattg actagtttaa tatgtaattc
    13081 tataaaatat ttttaatagt gtagcttttc gttgagataa taatataata aagaaaagtt
    13141 ctattctaat tgctaaacgg cttgaggtat atgctactgt tatagaaatg attttaaact
    13201 aaaatcaaaa ttactccaaa aatagtattg attttggttt aatacaaaac atatgtaata
    13261 atgtgagtca acaaaagtct gtttttgtac catactatct tgaaaaatct actaaattca
    13321 aattgagagg atgaattaaa atgaataaaa tatttatata tgcaggagtg cgaaatcata
    13381 actctaagac tttagagtat actaagagac tttcaagtat catttctagt agaaataatg
    13441 ttgatatatc tttcaggaca cctttcaatt cagagctaga aatatctaat tctgattcag
    13501 aagagttgtt taagaaagga attgataggc aaagtaatgc tgatgatgga ggtgttataa
    13561 aaaaagagtt attagagtct gatattataa ttatctcttc tcctgtatat ttacaaaacg
    13621 tatctgtgga cacaaaaaac tttattgaaa ggattggggg gtggagccat ctttttcgat
    13681 tagctggaaa gtttgttgta acattagatg ttgctgagag taacggctct gataatgtgt
    13741 cagaatatct tagagatata ttttcatata tgggaggaca gatattacac caagtttcaa
    13801 ttaccaattc actcaaagat attgcagagg ctcagttgat ggaggcaact tataaaattg
    13861 aagatgtact tgaagggaaa attaagtaca aaacaacgga ttatcaagaa agagcttacc
    13921 agacattaaa attaatttta gaaaattatg attccgaaca ttttgagaag atgtattggg
    13981 agaaaaaacg cctttttgaa gctaatagtt tagaggaatg gtattatgtt gaaaatatta
    14041 aataactctg tcatatattt atgtttgatt ccgttattgt tcctattatt gataattttt
    14101 ccaaatgatt cattaatcta ttattttcga ttgattttaa tttcgttaat atcaattaca
    14161 ttacatgaac taggtcattt tttagtggga agatgtttat cttataaact agagatgctt
    14221 gctactccct ttttcttcta tttcagaaaa aaaatatatt tcaaatttcc agtgttatta
    14281 gcattcggtt attgtcaaat gagtaataga aacattacta atgaaaaaaa tagtgatagg
    14341 aatttggtgt tctacttctt tgggggaggt ggagctaacc taattgtcgc aatattagca
    14401 cttttgggat ttgtgccgta cgcatcagaa ttttttattt tgaatataat tctttttcta
    14461 gttacggtat gtttaccaat tgatggaaca gatggcaatg ctattagaga gatagttttg
    14521 tattcaaaag attcaaaaac atatcagaga ttctttgcga acagtctcta taataatcct
    14581 tatataacaa tcgacgattt tgcaaaatta acctctaaag aaaaatcttt tttttcaaaa
    14641 tttgaaaaat gtttgataaa cctttacttt gaagtgaaag gtgaagggtc agcatttaca
    14701 attgctaatc atgaagtttt tgattcaaat attcaggaaa atattatcca tgagtactat
    14761 aaattactac ataaatcttc tgattggatt attccacaga acttatcttt agaagaagtt
    14821 gtttttacct tgtcaaacta tatttactcg aaaaataata aatatttaga aaagattaag
    14881 tatctaaaga aattagtaga ttttagacaa gaagaaatta tcgactttat tttgaacaag
    14941 gaggaagtat tgtgaaaatt ccaatgatat atcaaatgga aaattcagaa tgtggattag
    15001 catgctgtgc catgatattg aactatttta aatatgagat ttctttaaat gaactacgtg
    15061 aaatctaccc atcatccaga tctggatatt ctctcctatc tataagtaaa gttttaggag
    15121 attttaatat aagttctcat gcttttaaag cttcggtaag agatttaaaa ccgctcagtt
    15181 tcccactcat ttgcttctgg gagagttctc attttattat tcttgaaaaa attagtaaaa
    15241 acaagtttta tattttagat cctgcaaaag gcaggcagag aatgtcaata agtgaatttg
    15301 aaaggcatta ttcaaatatc attttaacat ttaaaaagtt agatagcttt atgtctcgta
    15361 aagataataa gaagtcgcct gttttaaagt atttttttaa gtataggaat aagctaggga
    15421 ttttattttt tgtaacagca ttattgtatg taatacaatc attagtacct atagctaata
    15481 gatacataat tgacacgaat ttcaaggacg attcgtattc gtctagaatg ttatttacta
    15541 tattatttat atttactgtt tcattctcac taatgtattt attaagacag atatatgttg
    15601 catccttaaa atatataatg gataaagaga ttagctatga ttttatgaaa catttgatat
    15661 atttacctta cagtttttat gaaaaacgta ctttagggga tatacttttt agagctaact
    15721 ctattgttta tataagagaa atactatcaa ataattttat agcagctata cttgatttgt
    15781 taatgattgt ggtttatgct gtggttttat ttagcttttc taagtacatg gtaatctttt
    15841 taatatcact aagtctagct ctatctattg taatgtatcc aatcataaaa atctcaaaaa
    15901 atttaattga taaaaatata aaagaaaagg ttaatgttca aaatattact tccgaagtaa
    15961 tttctaaaaa tagtgatatt aagctaactg gagaagagga attttggatt aacaaatggg
    16021 ataattttaa tacaaaacag ctcatcatag gtcgaaaact tgatatacat ttatcaattg
    16081 ttagtagtat aacgaatgtt ttacaaatta ttctccctgt tttgaccctt attgtaggtg
    16141 taaatataaa aacattcgaa caattgacgt taggacaaat tgtagcaata agtacagtct
    16201 caccatactt tatttctcct ataatttctt taagtgataa ctatatacaa ttaatgttat
    16261 taaagggata ttttttaaga atagaggatg tgtttaatac taaatccgaa ttaattccag
    16321 aaagagtcag tcaagatata aaatttgata aaaaaataga attaaaagat atttggtata
    16381 aatatggatt atttgatgat tatgttttga aaggaataaa tgttactatt aaaaaaggag
    16441 aaactgttgc tattgttgga gaatcaggtt caggtaagag tacattagct aaaattttat
    16501 taggtttatt agaacctaat attggttcaa tagaagttga tggagtagaa aaagaagaaa
    16561 ttggtcaaac attgtataga aagatttttg gagcagtgtt acaaaattca accctaagtt
    16621 atggtacctt aagagagaat ttgacatttg gacactttgt ttcagatgaa gaattaatga
    16681 caaatctaaa ttcaattggt cttagcaatg tagttaaatc tttacctctt ggattagaga
    16741 caatcatcgc tgaagaaggt aataactttt ctggagggca gcagcaaatg atacttttag
    16801 ctcgttgtct tttgtcgaaa ccttcggtag ttgttttgga cgaagcaaca agtagtttag
    16861 ataatttatc tcaacaaatt acaacttctt acttaagtga aatcggtacc actaagattt
    16921 taattgccca tcgactagat actatcaagt ctgcagataa gatcttagta atgcataatg
    16981 gtgaaattgt agagattggg acccatagag aacttcttga actaggaggc atttataagc
    17041 aattgtattc aaataattag tttttgatta aaagggtaaa tttatgaaga ttatgaaaaa
    17101 aaaatattgg actttagcga tattattctt ttgtttgttc aataattctg ttactgctca
    17161 agaaatacct aaaaatcttg atggcaatat aactcacact cagactagcg aaagtttttc
    17221 tgaatctgat gaaaaacagg ttgactattc taataaaaat caagaagaag tagaccaaaa
    17281 taaatttcgt attcaaatcg ataagacaga attatttgta acaacagata aacatttaga
    17341 aaaaaactgt tgtaaattgg aacttgaacc acaaataaat aacgatattg ttaactctga
    17401 aagtaataat ttactaggcg aagataattt agataataaa attaaggaaa atgtttctca
    17461 tctagataat agaggaggaa atatagagca tgacaaagat aacttagaat cgtcgattgt
    17521 aagaaaatat gaatgggata tagataaagt tactggtgga ggcgaaagtt ataaattata
    17581 ttctaaaagt aattctaaag tttcaattgc tattttagat tcaggagtcg atttacaaaa
    17641 tactggatta ctgaaaaatc tttcaaatca ctcaaaaaac tatgtcccca ataaaggata
    17701 tttaggaaaa gaggagggag aggaaggaat aatatcagat attcaagata gattaggtca
    17761 tggtacggct gttgtagctc aaattgtagg ggatgacaat attaatggag taaatcctca
    17821 cgttaatatt aacgtctata gaatatttgg taagtcgtca gctagtccag attggattgt
    17881 aaaagcaatt tttgatgctg tagatgatgg caatgatatt atcaatctta gtactggaca
    17941 atatttaatg attgatggag aatatgagga cggaacaaat gattttgaaa catttttgaa
    18001 gtataaaaag gctattgatt acgcgaatca aaaaggagta attatagtag ctgcattagg
    18061 gaatgactcc ctaaatgtat caaatcagtc agatttattg aaacttatta gttcacgcaa
    18121 aaaagtaaga aaaccaggat tagtagttga tgttccaagt tatttctcat ctacaatttc
    18181 ggtcggaggc atagatcgct taggtaattt atcagatttt agcaataaag gggattctga
    18241 tgcaatatat gcgcctgcag gctcaacatt atctctttca gaattaggac ttaataactt
    18301 tattaatgca gaaaaatata aagaagattg gattttttcg gcaacactag gaggatatac
    18361 gtatctttat ggaaactcat ttgctgctcc taaagtttct ggtgcgattg caatgattat
    18421 tgataaatac aaattaaaag atcagcccta taattatatg tttgtaaaaa aaattctgga
    18481 agaaacatta ccagtaaaaa atggtataaa agtgttaaat ataccaaacg tattgagata
    18541 tgatttgaat atgttacaat tagaatataa aaatgaacaa agttgggata gtttcataga
    18601 taatgttaat ttaattgagt tggaagagag aattcaaact actattggaa ttaaacaaat
    18661 aaacacacac aatattatta ctattgcccg agaagggtac tctcaaaatt atttacctaa
    18721 cacttcagaa aatacatata attcattaca agtcagttta gttggagtat tactactttt
    18781 tataagtatg gtaaatattt tatgggctaa aaaaagtaaa tgaaaataaa atttggagcc
    18841 ctctgaaaaa gtaagtccta cagttcaact aaaatgagtc aaaagatgaa tcaccttgat
    18901 gtaggggagt ttgtcttatt gctgcctgaa cacctccgtt cagaggaaga acattataaa
    18961 tctgtttttg aagacgactt aaccagtcgc atatctagtc aagatgaacg acagcaaatg
    19021 actgctacgg taggttattt agaatcaggt caggatcgtt ttgtgtataa tacgacccct
    19081 atttcttacc agcagttttt gaaagatcca atcatcattg ttataacacc ccaatcaact
    19141 ggtccacagt ccattttgtt ttggatagac gcagtacaga actacgttct ctttaatcaa
    19201 ttgtctgatg cccaggagct tatccagaga caaggcattg aaaattgggt ctcagaaatg
    19261 caaacaggtt accacaacta catcacatta ttggataata tccagaggga acgttgggta
    19321 atgctagcag gagctgtgct tgggattgca acttcaatct tgttgtttaa cactatgaat
    19381 aggctctact ttgaagaatt tagacgtgcc atttttatca aacgcattgc aggtctcagg
    19441 ttcttagaaa tccatcgcac ttatctcttt gctcaactgg gtgtgttttt actgggattt
    19501 gttgcgagtg tatttcttca ggtagagata ggagttgctt tcttagtctt gttactcttt
    19561 actggtctat ctcttttaca gttacatgtc caaatgcaga aagaaaacaa gatgtccatg
    19621 cttgttttga agggaggtta atatgattga acttaaacag gtgagtaaat cttttggaga
    19681 acgagagtta ttttcgaatc tttcaatgac atttgaggct ggaaaagtct atgccttaat
    19741 tggttcaagt ggtagcggaa aaacaacctt gatgaacatg attgggaaat tagaacctta
    19801 tgatgggacg attttttacc gaggtaaaga cttggccaat tataaatcaa gtgatttttt
    19861 ccgtcacgaa ttgggctacc tcttccagaa ctttggctta attgaaaacc aaagtattga
    19921 agaaaacctt aagctaggtc tcattggtca aaagttgagt cggtcggaac agcggttgag
    19981 gcagaagcag gctttagaac aggtcggcct ggtttatctt gacctagata agcgcatctt
    20041 tgagttatcg ggcggagaat cgcaacgggt tgccttggca aaaattatct taaagaatcc
    20101 accctttatt ctggcagatg agccaacagc ttcaatagac ccagcaacct ctcagttgat
    20161 tatggagatt ttgctatctc ttcgagatga taataggcta atcattatcg caacacataa
    20221 tccggcaatt tgggagatgg ctgatgaagt gttcacgatg gatcatctga aataaaaatc
    20281 cttgttttta attgcacgat gagttactga aatattatca tgaatcaaga attggagtta
    20341 atttagaatt gtacttaatt tagaattgta ctttattaat attgaggtaa ctttttcttg
    20401 ataaaggaag aaataatgga gaggaagtta gaatgaaaaa attcgacaat tatattattg
    20461 agaagccttg cgattctaat tcagataaac tgcaaaaaat cttaataatt gaaagtttgg
    20521 tagatgatat tttgcaattt tctctcagaa tcaataatag tgtaggagag attttcctcc
    20581 tacaaccgtt ttaaaagaaa actatcttta ttccatgtta ttttgaggaa gatattgtga
    20641 aagtcaaaga tgatgataaa gttgagtgga atttgttaga atttcaaaaa tttagagcat
    20701 ttttggctta gtaatctgtg ttgaaggctc aaaacctatg gtaaaaaagt agctttgaaa
    20761 acgtattgcc tccaaagatt tagttaaata atgatttaac acaaaaagaa attattgaag
    20821 ttctggaaag atgttgtttc agtattgaga aaaggtggga aaaacttgcg attttcacag
    20881 agaaaggaag aaaaagtata gaaatatagt caattgaaac aagaacagga taaaagaacc
    20941 ttttgtgcca tatttttctc ctttcgcttt acaattggat tgaacacctt tattgtatcg
    21001 cgtttggagt ttttttggta taaccttcga cgcacacccg catagcgggt gttttttttg
    21061 tctcgcacct aacggagcga gacaaactaa tagtcactta atcaaaaaac gcaccatatc
    21121 aaaaactaaa aagtttgata tcatgcgtca tgtcttaaac taattgacta tactttctat
    21181 tcaaatgagc ttttaaccaa ttgattgagc caatccactc ttaaaaccaa agagcaattt
    21241 ctcgcttagc tgactcttct gaatctgaac catgtacaac attttggata atctcatttt
    21301 ctccagcagc ttttgcaaaa tcacctcgaa tagtgcctgg taaagcttct tctggacgag
    21361 ttgcacccat catggtccgc caagtttcga ttactttggg accagaaatg acacccacaa
    21421 gaactggacc tgaagtcatg aattcacgaa tcggtgggta aaaactctga ccaaccaagt
    21481 cctgatagtg ctggtcaatc aactcttctg aaacctgtga acgaaactcc aatttttcga
    21541 ttgtaaatcc acgttgttcg atgcgcttta acacttcacc cactagccct ctttttacac
    21601 catctggttt gatgataaag aatgtttgtt ccatacccgt ctcctttgtc agcttctttc
    21661 ttttatttta ccacatttcg tggaaaaatg gagaaagttt tcagaagaga gaatgagaga
    21721 accctcgggt tctctcattc tctcttattc tactgtttct tccacagttt caacggcagt
    21781 atccacaact acttctgttg tttcttcatt tccttcttcc tctactggag gattaaggta
    21841 ttcttcttcg ttgacagcat gtggttcaag gttacggtaa cgggccatac cagtaccagc
    21901 tgggatgatc ttaccgatga taacattttc tttaagtcca aggagatggt ctttcttacc
    21961 acggatagct gcgtcagtaa ggacacgagt tgtttcctgg aaggaagccg ctgacaagaa
    22021 actgtttgtt tcaagtgagg ctttggtaat tcccataagg actgggcgac ctgtcgctgg
    22081 aactccacct gcgataagga catctttgtt ggcatctgta aagtcattga tatccatgag
    22141 ggtacccatg agaagatctg tatcacctgg atccatgaca cggactttac ggatcatttg
    22201 acgaaccatt acctcgatgt gtttgtcacc gatttctacc ccttggctac ggtaaacttt
    22261 ttgtacttca ccgagaaggt acgtttcaac tgacaagaca tcacgaactg caaggagacg
    22321 ttttggttgg atagaacctt ctgtcagagc agcaccacgc gctacttggc ccccaacttc
    22381 gacacgcata cgagctgtaa atggaacgac atattcacct tcgccagttt cacccttaac
    22441 aaagactttc ttggtacgag ttgatgcatc ttcttcgata gcagtaactt gtcctttaac
    22501 ctctgtaata accgcttccc ctttaggatt gcgggcttca aagatttctt ggacacgagg
    22561 aagaccctga gtgatatcgg tatttgaggc aaccccacct gtgtggaagg tacgcattgt
    22621 aagctgtgta ccaggttccc cgatagattg ggcagcgatt gtaccaactg cttcaccaac
    22681 ttcaaccgca tcaccagtcg ccaagttgat accgtaacag tgacggcaga caccgtgacg
    22741 agtgttacat gtaaatacag aacggatagt cacttcttcc acaccagcat tgacaatttc
    22801 acgcgccttg tcttctgtaa tcaattcatt tggaccaata atcactgcac cagtttctgg
    22861 atgtttaaca gttttcttag tgtaacgacc gttgagacgc tcttcgagag actcgatcat
    22921 ctcttttcct tctgcgatag aacggatcaa gagaccacgg tcagttccac agtcgtcctc
    22981 acggatgata a
//
