LOCUS       NZ_CP082820            13099 bp    DNA     circular CON 26-OCT-2024
DEFINITION  Streptococcus pneumoniae strain SCAID PHRX1-2021 chromosome,
            complete genome.
ACCESSION   NZ_CP082820
VERSION     NZ_CP082820.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2098200)
  AUTHORS   Korotetskiy,I., Kerimzhanova,B., Jumagaziyeva,A., Myrzabayeva,A.,
            Shilov,S., Kuznetsova,T., Iskakbayeva,Z., Myrzagali,A., Reva,O.,
            Satylgankyzy,G., Korotetskaya,N., Zubenko,N. and Ivanova,L.
  TITLE     Clinical isolates genome sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2098200)
  AUTHORS   Korotetskiy,I., Kerimzhanova,B., Jumagaziyeva,A., Myrzabayeva,A.,
            Shilov,S., Kuznetsova,T., Iskakbayeva,Z., Myrzagali,A., Reva,O.,
            Satylgankyzy,G., Korotetskaya,N., Zubenko,N. and Ivanova,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2021) Virology and microbiology, Scientific Center
            for Anti-infectious Drugs (SCAID), 75A Al Farabi Ave., Almaty
            050060, Kazakhstan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: LR216047
            Genome Coverage                   :: 386x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019915285.1-RS_2024_10_26
            Annotation Date                   :: 10/26/2024 03:31:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,134
            CDSs (total)                      :: 2,061
            Genes (coding)                    :: 1,894
            CDSs (with protein)               :: 1,894
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 167
            CDSs (without protein)            :: 167
            Pseudo Genes (ambiguous residues) :: 0 of 167
            Pseudo Genes (frameshifted)       :: 87 of 167
            Pseudo Genes (incomplete)         :: 79 of 167
            Pseudo Genes (internal stop)      :: 50 of 167
            Pseudo Genes (multiple problems)  :: 42 of 167
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 33764
            Orig. end                         :: 46863
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP082820.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..13099
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..13099
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13099
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:8099](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8099
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(139..1149)
                     /locus_tag="K8B76_RS00180"
                     /old_locus_tag="K8B76_00180"
     CDS             complement(139..1149)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /locus_tag="K8B76_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00180"
                     /product="YeiH family protein"
                     /protein_id="WP_000009179.1"
                     /transl_table=11
                     /translation="MSFLSKNGAGILVCLLISIVSWYLGGFFPVIGAPVFAIFMGMLLH
                     PFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALIVA
                     YLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVLAAL
                     IFPTLGTWLHLSNDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLTRTLA
                     IIPITLFLSYWQSREQKNKQGLQLKKVFPLFILYFILASLLTTLLTSLGVSSSFFTPLK
                     QLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIGIF"
     gene            1298..2467
                     /locus_tag="K8B76_RS00185"
                     /old_locus_tag="K8B76_00185"
     CDS             1298..2467
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     8.2e-64. Score: 207.9. Matches aSDomain:
                     nrpspksdomains_K8B76_RS00185_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="K8B76_RS00185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00185"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366379.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.4e-62, bitscore:
                     208.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-07, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.8e-07,
                     bitscore: 27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPAVFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        1391..2443
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K8B76_RS00185_Aminotran_1_2.1"
                     /evalue="8.20E-64"
                     /label="K8B76_RS00185_Aminotran_1_2.1"
                     /locus_tag="K8B76_RS00185"
                     /protein_end="382"
                     /protein_start="31"
                     /score="207.9"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     VFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            2464..3234
                     /gene="recO"
                     /locus_tag="K8B76_RS00190"
                     /old_locus_tag="K8B76_00190"
     CDS             2464..3234
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="K8B76_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00190"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616162.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3231..4223
                     /gene="plsX"
                     /locus_tag="K8B76_RS00195"
                     /old_locus_tag="K8B76_00195"
     CDS             3231..4223
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="K8B76_RS00195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00195"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717460.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIVGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4229..4462
                     /locus_tag="K8B76_RS00200"
                     /old_locus_tag="K8B76_00200"
     CDS             4229..4462
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 3e-11.
                     Score: 35.5. Matches aSDomain:
                     nrpspksdomains_K8B76_RS00200_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="K8B76_RS00200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00200"
                     /product="acyl carrier protein"
                     /protein_id="WP_000136447.1"
                     /sec_met_domain="PP-binding (E-value: 1.6e-10, bitscore:
                     38.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.00056, bitscore:
                     17.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     aSDomain        4253..4444
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K8B76_RS00200_PP-binding.1"
                     /evalue="3.00E-11"
                     /label="K8B76_RS00200_PP-binding.1"
                     /locus_tag="K8B76_RS00200"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.5"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     gene            <4499..4798
                     /locus_tag="K8B76_RS00205"
                     /old_locus_tag="K8B76_00205"
                     /pseudo=""
     CDS             <4499..4798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="K8B76_RS00205"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00205"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LEMRNIGQAGKILADSGYQGLMKIYPQAQTPRKSSKLKPLTVEDK
                     ACNHALSKERSKVENIFAKVKTFKMFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     misc_feature    complement(4516..4531)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(4840..4853)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     misc_feature    4861..4874
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.29"
                     /tool="antismash"
     gene            5001..5231
                     /gene="blpU"
                     /locus_tag="K8B76_RS00210"
                     /old_locus_tag="K8B76_00210"
     CDS             5001..5231
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="K8B76_RS00210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00210"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093068.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.3e-16,
                     bitscore: 55.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKKMSQFEIMDTDMLACVEGGGCNWGDFAKAGVGGGAARGLQL
                     GIKTRTWQGAATGAVGGAILGGVAYAATCWW"
     misc_feature    5018..5032
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            5234..5359
                     /locus_tag="K8B76_RS10540"
     CDS             5234..5359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="K8B76_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            5946..8099
                     /gene="comA"
                     /locus_tag="K8B76_RS00215"
                     /old_locus_tag="K8B76_00215"
     CDS             5946..8099
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="K8B76_RS00215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00215"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_000668287.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.3e-42, bitscore:
                     140.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1125.2,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMAFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            8112..9461
                     /gene="comB"
                     /locus_tag="K8B76_RS00220"
                     /old_locus_tag="K8B76_00220"
     CDS             8112..9461
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="K8B76_RS00220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00220"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_000801625.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQSEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            9631..10338
                     /gene="purC"
                     /locus_tag="K8B76_RS00225"
                     /old_locus_tag="K8B76_00225"
     CDS             9631..10338
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312208.1"
                     /locus_tag="K8B76_RS00225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K8B76_00225"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043300.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQELK"
     gene            10349..10483
                     /locus_tag="K8B76_RS10950"
     CDS             10349..10483
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429437.1"
                     /locus_tag="K8B76_RS10950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000429437.1"
                     /transl_table=11
                     /translation="MENLRLSTKRTQAEKVPQTFSLCRELGEPTDVYEIVWEKLQGLK"
     misc_feature    complement(10554..10567)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     misc_feature    11265..11279
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    12025..12035
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 actgttttga ggttgtagat acgactgacg aagtcagctc aaaacaccgt tttgaggttg
       61 cagatagaac tgacgaagtc agtaacatat atacggcaag gcgacgttga cgtggtttga
      121 agagattttc gaagagtatt agaaaatgcc gataagggtc tgcataccaa ggctggtgag
      181 gatgatggca atccagcaga cggctccgag aacaatggat tttccactgg atttgaccat
      241 agcgaccaga ttagttttga gaccgatggc actcatggcc atgataatga ggaatttaga
      301 gagttgtttg agaggggtaa agaaactact agacacaccg agagaggtca gaagggtggt
      361 taggagcgat gcaaggatga agtaaaggat aaaaagtggg aagacttttt tcagttgtaa
      421 gccttgctta tttttttgct cgcgactttg ccagtaggag agaaagagag tgatggggat
      481 gatagctagg gtgcgcgtga gtttgacaat ggttgcggat tcgagggtat tggtctggta
      541 gagactgtcc caagcgctag ctgtggcggt tacagaggaa gtatcattga ccgcagttcc
      601 tgcaaagagg gcgaagccgt cattggatag atgaagccag gtgccgaggg ttggaaagat
      661 gagcgcagcc aagacattga agaaaaagat aacggagatg gcttgggcta cttccttttc
      721 cttagcatgg ataacaggcg ctgtcgctgc aatggcagaa cccccacaga tagaagaacc
      781 tactccaatc aaggtagcca gttttgtatc cagggcaaag aagcgctgga agaggtaggc
      841 aacaatcaag gctattgaaa tggtggaaag gatgacaggg agtgaagatt gcccaactgc
      901 gaagacttga gagatattga gaccaaaacc aagtaagata acggcatact ggagcaattt
      961 cttggaacta aaggtcaatc caacatccag ttgtttataa gacgagagaa agggatgtag
     1021 gagcatgccc ataaaaatcg caaaaacggg tgcgccaata acagggaaga atcctcctaa
     1081 gtaccaagat acgatagaaa tgagaaggca gaccaagatg cctgctccat tttttgatag
     1141 aaatgacata aaaacctcca aatagaatct gttaccatta tagacctgta aacaggaaaa
     1201 gtaaaataga aagtggaaag ctattctcta atgtattttt gcggtcgggg ggcttttgta
     1261 gtataataga gatacgtttt gaaagtagga ggtatctatg gacttaacta agcgctttaa
     1321 taaacagtta gataaaattc aagtttcgtt gattcgtcag tttgaccagg ttatttcgga
     1381 gattcctggg gtcttgcgtt tgaccttggg ggaacctgat tttacaacgc cagaccatgt
     1441 caaggaggcg gccaagcgag cgattgatca gaaccaatcc tactatacag ggatgagtgg
     1501 tctgctgact ctacgtcagg cagccagtga ctttgttaag gaaaagtacc aactggacta
     1561 tgctcctgaa aatgaaatct tggttacaat tggggcgaca gaggctttat ctgcgacttt
     1621 gacggctatt ttggaagagg gagacaaggt acttttacca gctcctgctt atccaggcta
     1681 tgaaccgatt gttaacttag ttggggcaga aattgttgag attgatacga ctgaaaatgg
     1741 ttttgtcttg actcctgaga tgttggagaa ggccattttg gagcagggtg ataagctcaa
     1801 ggcggttatt ctcaactatc cagccaatcc gacaggaatt acctacagtc gagagcagtt
     1861 agaggccttg gcagctgttt tacgcaagta cgaaattttt gttgtctgtg atgaggttta
     1921 ctcagaattg acctacacag gcgaagccca tgtgtctcta ggaacgatgt tgagagacca
     1981 ggctattatt atcaatggtt tgtctaaatc gcatgccatg acaggttggc gtttggggct
     2041 gattttcgct cctgcggtct tcacagccca gttaatcaag agtcaccaat acttggtcac
     2101 tgccgcaaat accatggcgc aacatgctgc ggtagaagcc ttgacggctg gtaaaaatga
     2161 tgcggagccc atgaagaagg aatatatcca gcgtcgggac tatatcatcg aaaaaatgac
     2221 tgctcttggt tttgagatta tcaaaccaga cggtgccttc tatatttttg ctaaaattcc
     2281 agcgggctac aatcaagact cctttgcttt tctgaaggat tttgctcaga agaaggccgt
     2341 tgcctttatc cctggtgcag cctttggacg ttacggggaa ggctacgtcc gcctatctta
     2401 tgcagccagc atggagacta tcaaagaagc catgaaacga cttgaggagt acatgagaga
     2461 agcatgattc agtctatcac gagtcaaggc ttggtgcttt acaatcgcaa ttttcgtgag
     2521 gatgacaagc tcgtcaaaat ttttacagag caggttggca aacgcatgtt ttttgtcaaa
     2581 cacgctggtc agtctaagct ggcgcctgtt attcagccct tggtgttggc acgatttctc
     2641 ttgcgaatca atgatgacgg actcagttac atcgaagact atcatgaggt catgactttt
     2701 cccaagatta atagtgacct ctttgtcatg gcctatgcga cctatgtggc agctcttgca
     2761 gatgctagtt tgcaggacaa tcagcaggat gctcccttgt ttgctttttt gcaaaagact
     2821 ttggagttga tggaagcagg cttggattat caggttttga ccaatatttt tgaaattcaa
     2881 attttgactc gatttggaat cagcctcaat tttaatgagt gtgtcttctg ccatcgggtt
     2941 ggtcaggctt ttgacttttc tttcaaatat ggagcctgcc tctgtccaga gcattatcat
     3001 gaggatgaga gacgttgtca tctcaatccc aatatcccct atctgctcaa tcaatttcaa
     3061 gctattgatt ttgagacttt ggagaccatt tcgctcaagc ctggaatcaa gcaagagcta
     3121 cgccaattta tggatcaatt atatgaagag tacgttggga ttcacctaaa atcaaagaaa
     3181 tttattgatt ccctagcaga ctggggacaa ttactaaaag aggaaaagaa atgaaaaaaa
     3241 tcgcagtaga tgccatgggg ggcgattacg cacctcaggc cattgttgag ggtgtcaatc
     3301 aagccctatc tgacttttca gatatcgagg ttcaacttta cggagatgaa gctaaaatca
     3361 agcaatatct gacagcgaca gagcgcgtca gcattatcca tacggatgag aagattgatt
     3421 cggatgatga acctacgaga gctattagga ataagaaaaa tgccagtatg gtattggcag
     3481 ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat acaggtgcct
     3541 tgttggcagc aggattcttc atcgtgggtc gtatcaagaa tatcgaccgt cctggactca
     3601 tgtctacctt gcctaccgtt gatggaaaag gttttgacat gctagacctt ggtgccaatg
     3661 cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc tatgctaaaa
     3721 atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca gagagtagca
     3781 agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa agtttgaact
     3841 ttatcggaaa cgtggaagcg cgtgatttga tgaatggcgt tgcagatgtt gttgtggcag
     3901 atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg ggaatcgtgg
     3961 gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt gccctccttc
     4021 tcaaggacag cctcagtggt ttgaaaaaac agctcaatta ttcagatgtt ggtggagcgg
     4081 tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat gccaaggctg
     4141 tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt gcccagactg
     4201 cgcgtgaatt ttcaggagaa taaaagagat gacagaaaaa gaaatttttg accgtattgt
     4261 gaccattatc caagagcgac agggagagga ctttgtcgtg acagaatcct tgagtctgaa
     4321 agacgatttg gatgcggatt ctgttgactt gatggagttt atcttgactc tggaagatga
     4381 atttagtatc gaaatcagcg atgaagaaat tgaccaactc caaaacgtag gagatgtggt
     4441 taaaatcatt caaggaaaat agcaatcgga gttccaagtc aacggaagta gatggttttt
     4501 agaaatgaga aatatcggac aagctggtaa aatcttggct gacagtggtt atcaagggct
     4561 catgaagata tatcctcaag cacaaactcc acgtaaatcc agcaaactca agccgctaac
     4621 agttgaagat aaagcctgta atcatgcgct atctaaggag agaagcaagg ttgagaatat
     4681 ctttgccaaa gtaaaaacgt ttaaaatgtt ttcaacaacc tatcgaaatc atcgtaaacg
     4741 cttcggatta cgaatgaatt tgattgctgg tattatcaat catgaactag gattctagtt
     4801 ttgcaggaag tctaatagta aaaaagtgat tagaaaacat cttttttaaa aatagagatg
     4861 attttgaaac aaaaaagcta attcaagacg tttcgatgcc aattcaagat ttggatgaaa
     4921 aaaattaata gatactgtta tactaaactt gtcaagtttg taacaagaca aatattaaaa
     4981 ataaaaaaga ggtattcgtt atgaatacaa aaaagatgtc acaatttgaa attatggata
     5041 ctgatatgct tgcttgcgtt gaaggtggcg gatgcaattg gggagatttt gccaaagcag
     5101 gtgttggagg aggagcagca cgaggtcttc agctaggaat taaaacaaga acatggcaag
     5161 gtgcagcaac tggtgctgtg ggaggagcta tacttggagg tgtggcctat gcagcgacat
     5221 gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg
     5281 tccttatatg gatgatttaa ttagaaaaaa atttttaaag tcttcggaga agaaaacaga
     5341 aaaatctgtt aaaaaataat caaaactata aatgatgaat ctgaatcaaa attattttgc
     5401 gcatgtaaag aggagtctta tagtaacgag tcaaaaaagg agtaactatg aatcgtaatt
     5461 tagaacggtg ttatctattc tgactaggaa tagatcatac cagaggtagc ttagaaatag
     5521 cagagacatt agaaattgaa gtaataaata ggatgtcgta agtgttacta tcaatgattt
     5581 atttgtttca agcttgccta gggtgacagt aaaaaatcaa tttcctttca atagcatatt
     5641 tttagtgggc aggactcttg ttctgcctat ttttttatcc aaaaagtgca gttgggaggg
     5701 agataggctc atttgggaag gaagtccagt ttttgtttag tgattgaggt aagatagttg
     5761 ttatcagatg agtttatact cttcgaaaat caaattcaaa ccacgtcaac gtcgccttga
     5821 cgtatatatg tgactgactt cgtcagtcct atctacaacc tcaaaacagt gttttgagca
     5881 gcctgcggct agtttcctag tttgctcttt gattttcatt gagtattagg gaaaaggaga
     5941 tgaatatgaa atttgggaaa cgtcactatc gtccgcaagt ggatcagatg gactgcggtg
     6001 tagcttcatt agccatggtt tttggctact atggtagtta ttattttttg gctcacttgc
     6061 gagaattggc taagacgacc atggatggga cgacggcttt gggcttggtc aaggtggcag
     6121 aggagattgg ttttgagacg cgagccatta aggcggatat gacgcttttt gacttgccgg
     6181 atttgacttt tccttttgtt gcccatgtgc ttaaggaagg gaaattgctc cactactatg
     6241 tggtgactgg gcaggataag gatagcattc atattgccga tccagatccc ggggtgaagt
     6301 tgactaaact gccacgtgag cgttttgagg aagaatggac aggagtgact ctttttatgg
     6361 cacctagtcc agactataag cctcataagg aacaaaaaaa tggtctgctc tcttttatcc
     6421 ctatattagt gaagcagcgt ggcttgattg ccaatatcgt tttggcaaca ctcttggtaa
     6481 ccgtgattaa cattgtgggt tcttattatc tgcagtctat cattgatacc tatgtgccag
     6541 atcagatgcg ttcgacacta gggattattt ctattgggct agtcatcgtc tacatcctcc
     6601 agcaaatctt gtcttacgct caggagtatc tcttgcttgt tttggggcaa cgcttgtcga
     6661 ttgacgtgat tttgtcctat atcaagcatg tttttcacct ccctatgtcc ttctttgcga
     6721 cacgcaggac aggggagatc gtgtctcgtt ttacagatgc taacagtatt atcgatgcgc
     6781 tggcttcgac cattctttcg attttcctag atgtgtcaac agttgtcatt atttcccttg
     6841 ttttattttc acaaaatacc aatctctttt tcatgacttt attggcgctt cctatctaca
     6901 cagtgattat ctttgccttt atgaagccgt ttgaaaagat gaatcgggac accatggaag
     6961 ccaatgcggt tctgtcttct tctatcattg aggacatcaa cggtattgag actatcaagt
     7021 ccttgaccag tgaaagtcag cgttaccaaa aaattgacaa ggaatttgtg gattatctga
     7081 agaaatcctt tacctatagt cgagcagaga gtcagcaaaa ggctctgaaa aaggttgccc
     7141 atctcttgct taatgtcggc attctctgga tgggggctgt tctggtcatg gatggcaaga
     7201 tgagtttggg gcagttgatt acctataata ccttgctggt ttactttacc aatcctttgg
     7261 aaaatatcat caatctgcaa accaagcttc agacagcgca ggttgccaat aaccgtctaa
     7321 atgaagtgta tctagtagct tctgagtttg aggagaagaa aacagttgag gatttgagct
     7381 tgatgaaggg agatatggcc ttcaagcagg ttcattacaa gtatggctat ggtcgagacg
     7441 tcttgtcgga tatcaattta accgttcccc aagggtctaa ggtggctttt gtggggattt
     7501 cagggtcagg taagacgact ttggccaaga tgatggttaa tttttacgac ccaagtcaag
     7561 gggagattag tctgggtagt gtcaatctca atcagattga taaaaaagcc ctgcgccagt
     7621 acatcaacta tctgcctcaa cagccctatg tctttaacgg aacgattttg gagaatcttc
     7681 ttttgggagc caaggagggg acgacacagg aagatatctt acgggcggtc gaattggcag
     7741 agattcgaga ggatatcgag cgcatgccac tgaattacca gacagaattg acttcggatg
     7801 gggcagggat ttcaggtggt caacgtcaga gaatcgcttt ggcgcgtgct ctcttgacag
     7861 atgcgccggt cttgattttg gatgaggcga ctagcagttt ggatattttg acagagaagc
     7921 ggattgtcga taatctcatg gctttggaca agaccttgat tttcattgct caccgcttga
     7981 ctattgctga gcggacagag aaggtagttg tcttggatca gggcaagatt gtcgaagaag
     8041 gaaagcatgc tgatttgctt gcacagggtg gcttttacgc ccatttggtc aatagctaga
     8101 aagaggagag gatgaaacca gaatttttag aaagtgcgga gttttataat cgtcgttacc
     8161 ataatttttc cagtagtgtg attgtaccca tggcccttct gctcgtgttt ttacttggct
     8221 ttgcaactgt tgcagaaaag gagatgagtt tgtccactag agctactgtc gaacctagtc
     8281 gtatccttgc aaatatccag tcaactagca acaatcgtat tcttgtcaat catttggaag
     8341 aaaataagct ggttaagaag ggggatcttt tggttcaata ccaagaaggg gcagagggtg
     8401 tccaagcgga gtcctatgcc agtcagttgg acatgctaaa ggatcaaaaa aagcaattgg
     8461 agtatctgca aaagagcctg caagaagggg agaaccactt tccagaggag gataagtttg
     8521 gctaccaagc cacctttcgc gactacatca gtcaagcagg cagtcttagg gctagtacat
     8581 cgcaacaaaa tgagaccatc gcgtcccaga atgcagcagc tagccaaacc caatccgaaa
     8641 tcggcaacct catcagtcaa acagaggcta aaattcgcga ttaccagaca gctaagtcag
     8701 ctattgaaac aggtgcttcc ttggccggtc agaatctagc ctactctctt taccagtcct
     8761 acaagtctca gggcgaggaa aatccccaaa ctaaggttca ggcagttgca caggttgaag
     8821 cacagatttc tcagttagaa tctagtcttg ctacttaccg tgtccagtat gcaggttcag
     8881 gtacccagca agcctatgcg tcagggttaa gcagtcaatt ggaatccctt aaatcccaac
     8941 acttggcaaa ggttggtcag gaattgaccc ttctagccca gaaaatcttg gaggcagagt
     9001 caggtaagaa ggtacaggga aatcttttag acaaggggaa aattacggca agtgaggatg
     9061 gggtgcttca tcttaatcct gagaccagtg attctagcat ggttgcagaa ggtgccctac
     9121 tagcccaact ttatccatct ttggaaagag aagggaaagc caaactcaca gcctatctaa
     9181 gttcaaaaga tgtagcaaga atcaaggtcg gtgattctgt tcgctatact acgactcatg
     9241 atgccgggaa tcaacttttt ctagattcta ctattacaag tattgatgcg acagctacta
     9301 agactgagaa agggaatttc tttaaaatcg aggcggagac taatctaact tcggagcagg
     9361 ctgaaaaact taggtacggg gtggaaggcc gcttgcagat gattacgggc aagaaaagtt
     9421 atctacgtta ttatttggat caatttttga acaaagagta atgttcgtgt ttttagagtt
     9481 aaataatttt taaactgtga gaaagattct tcttgcagtt ttttctttac attttttgaa
     9541 aaacatctgc tatttattcg gttaaattct tgtgtttttt ggttttttgt ggtaaaatgt
     9601 gctcaagtaa tacgaaaggc gaactttaaa atgtcaaaac aattgatcta ttcgggaaaa
     9661 gctaaagata tctatacaac tgaggatgaa aatcttatta tttcaactta caaggaccag
     9721 gcgactgctt tcaacggtgt caagaaggag cagattgcag gtaagggagt cttgaataat
     9781 cagatctcat cttttatttt tgagaaatta aatgcggctg gtgtggcgac tcactttgtg
     9841 gagaaacttt cagacacgga acaactcaat aaaaaggtta agattattcc tttggaagtc
     9901 gtgctccgca actatactgc tggttccttt tcaaaacgtt ttggtgtgga tgagggaatc
     9961 gccttggaga ctccgattgt cgaattttac tacaaaaatg atgatttgga tgatccattt
    10021 atcaatgatg agcatgtgaa attcctacag attgcggatg accagcagat tgcctacttg
    10081 aaggaagaaa cgcgtcgtat caatgaacta ttgaaagtct ggtttgctga gattgggctt
    10141 aaattgattg actttaagct agagttcggt tttgacaagg atggcaagat tatcttggca
    10201 gacgaatttt caccagataa ctgccgcttg tgggatgctg atggcaacca catggataag
    10261 gatgttttcc gtagaggatt gggagaacta accgacgttt atgagattgt ttgggaaaag
    10321 ttgcaggaat tgaaataatc tgtttgcaat ggaaaacctt cgtctctcaa ctaaaaggac
    10381 tcaggctgaa aaggtccccc agaccttttc actctgtaga gaactaggtg aaccaaccga
    10441 tgtttacgaa attgtctggg aaaagttgca gggtttaaaa taacaacctc aaggctgttt
    10501 gggaatattg caagagctga aataaaggaa taagaattga tggataaacg tatttttgtt
    10561 gaaaaaaagg ctgattttca ggtcaagtca gagagtttgg ttagagaact ccagcacaac
    10621 ttgggactgt caagcttgaa aagtattcgt attgtgcaag tatatgatgt atttgacttg
    10681 gttgaggact tgtttgcacc tgcagagaag cacattttct ctgagcaggt aaccgaccat
    10741 gttttagatg aagtatctgt gcaggcggat cttgctaact atgctttctt tgccattgaa
    10801 agtctgccag ggcagtttga ccagcgtgca gcttcgtcac aggaagcctt gcttttgttg
    10861 ggaagttcga gtgacgtgac agtcaacaca gcccaacttt acttggtgaa taaagatatt
    10921 gatgcgactg agttgaaagc tgtcaaaaac tacctgctca atccagttga ttctcgtttc
    10981 aaggatatca cgacagggat tgccaagcag gagttttcag agtcagacaa gaccattcca
    11041 aaattgactt tctttgaaag ctatacagca gaagactttg ctcgctacaa ggccgaacaa
    11101 gggatggcca tggaagtgga tgatttgctc tttatccaag actactttaa gtcaatcggg
    11161 cgcgtgccaa ctgagactga acttaaggtt ttggacactt actggtctga ccactgccgt
    11221 catacgactt ttgagacaga gttgaaacac atcgactttt cagcttctaa atttcaaaag
    11281 caattgcagt caacctatga caagtatatt gccatgcgcg aggaattagg tcggtctgaa
    11341 aaaccacaaa ccttgatgga tatggcgact attttcggtc gttatgagcg tgctaatgga
    11401 cgattggatg atatggaagt ctctgacgaa atcaatgcct gctcagttga aattgaagtg
    11461 gacgttgatg gtgtcaagga accttggctc ctcatgttta aaaacgaaac ccacaaccat
    11521 ccaacagaaa ttgagccatt tggtggagcg gctacctgta ttggtggagc tattcgtgat
    11581 ccgttgtcag gccgttccta tgtttaccaa gccatgcgta tttcaggtgc tggtgatatt
    11641 acagcaccga tttcggaaac tcgtgctggg aaattgccac aacaagtcat ttctaaaaca
    11701 gcagctcatg gttattcttc atatggtaac cagattgggc ttgccacaac ctacgttcgt
    11761 gaatacttcc acccaggctt tgtagctaaa cgtatggaac ttggtgccgt tgttggtgcg
    11821 gctcccaagg gcaatgttgt ccgtgaaaaa cctgaagcag gtgatgtgat catccttctc
    11881 ggaggcaaaa caggtcgtga tggtgtcggt ggtgcgacgg gctcttctaa ggttcaaaca
    11941 gttgagtctg tagagactgc tggtgctgag gttcaaaaag gaaatgccat cgaagaacgc
    12001 aagattcagc gcctcttccg taatggcaat gtcactcgtc tgatcaagaa gtccaatgac
    12061 tttggtgcag gcggcgtctg tgtggctatc ggtgaattgg cagacggtct tgaaatcgac
    12121 ctcaacaagg tgcctcttaa ataccagggc ttgaatggta cagaaattgc catctctgaa
    12181 tcacaagaac ggatggcggt cgtggttcgt cctgaagatg tggatgcctt cgttgccgaa
    12241 tgtaacaaag aaaatattga tgctgttgtg gtggcgacag taactgaaaa accaaatctt
    12301 gtcatgcact ggaatggtga gacaatcgtt gacttggagc gtcgtttcct tgacaccaat
    12361 ggtgtgcgcg tggttgtcga tgccaaagtt gtggacaagg atgtcaaact cccagaagag
    12421 cgtcaaacat ctgctgaaac actggaatca gataccctta cggttctatc tgacctcaac
    12481 catgcaagtc aaaaaggatt acagactgtc tttgactgct ctgttggacg ctcaacggtt
    12541 aatcacccac ttggtggtcg ttaccaactc acaccaactg aggcatctgt gcagaaattg
    12601 ccagttcaac acggtgtgac tcatactgcg tcggtcattg ctcaaggttt caacccatat
    12661 gtagctgaat ggtctccata ccacggtgct gcttatgcgg ttatcgaagc aactgctcgt
    12721 ttggtggctg ctggtgccaa ctggtccaag gctcgtttct cttaccaaga gtatttcgag
    12781 cgtatggata aacaagcaga gcgtttcggt cagccagtag ctgctcttct aggttctatt
    12841 gaagcacaaa ttcaacttgg cttgccatct atcggtggta aggactccat gtctggtacc
    12901 tttgaagaat tgaccgttcc gccaaccttg gttgcctttg gggtgacgac ggcagatagc
    12961 cgtaaggtgc tctctccaga atttaaagct gttggggaaa atatctacta catcccaggt
    13021 caagccctct ctgcagagat tgattttgac ttgattaaga aaaattttgc tcagtttgaa
    13081 gccatccaag ctgaccata
//
