LOCUS       NZ_JAIHBQ010000001     10420 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7361471
            Orig. end                         :: 7371891
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10420
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="27"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10420
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10420
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5420](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5420)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            1478..2050
                     /locus_tag="K4902_RS33355"
                     /old_locus_tag="K4902_33355"
     CDS             1478..2050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031806.1"
                     /locus_tag="K4902_RS33355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33355"
                     /product="HPP family protein"
                     /protein_id="WP_079197034.1"
                     /transl_table=11
                     /translation="MSTDTALRPEPAPTAAAGSDERSPRRRRMAGRAPARPAPAAAFHN
                     VSAATAALLGLVAIGAVIHEPVLIPPLAASAALVHCAPALPLAQPRSVVVGHLLGAAAG
                     YAVAAVAAQGSAWAAALAAGLTLALTTLARTPHSPACATAVVIVLQAPAPGRFVPLLFG
                     STVLLVVTAFAASRVRRGSPRYPAYWW"
     gene            2127..2351
                     /locus_tag="K4902_RS33360"
                     /old_locus_tag="K4902_33360"
     CDS             2127..2351
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383400.1"
                     /locus_tag="K4902_RS33360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33360"
                     /product="DUF6458 family protein"
                     /protein_id="WP_073815459.1"
                     /transl_table=11
                     /translation="MGLGVCIILIAVGAILTFASDWQVDGVNLDLVGLILMAVGIIGTA
                     VYTSILRRRRLVVPPATTTVAENDRRDLL"
     gene            complement(2464..2889)
                     /locus_tag="K4902_RS33365"
                     /old_locus_tag="K4902_33365"
     CDS             complement(2464..2889)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979912.1"
                     /locus_tag="K4902_RS33365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33365"
                     /product="ATP-binding protein"
                     /protein_id="WP_241845620.1"
                     /transl_table=11
                     /translation="MNTRSDTLSRAAAADPHGTGHGGSSPVRTPAQARGLVRHALAALG
                     PLRPSQVEDLLLVTSELVTNALRHGGGVTGFGIRVGPDVVTLSVADASGISPLYQLRDE
                     LRPGGFGWPIVLRLCREVSVDTRPDGKTIHATVAVDR"
     misc_feature    complement(2904..2920)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            3067..3939
                     /locus_tag="K4902_RS33370"
                     /old_locus_tag="K4902_33370"
     CDS             3067..3939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031437.1"
                     /locus_tag="K4902_RS33370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33370"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_073815457.1"
                     /transl_table=11
                     /translation="MRTQPAEATTTYTTNGTREDLPVLDAPHRLPPQDARALSKVFFRE
                     LAAREEGTAEHQYVRNTLIEMNMSLVRYAAGRFRARGDEMEDIVQVGMVGLIKAIDRFD
                     LSREVEFATFAVPYIVGEIKRFFRDTTWAVHVPRRLQEARVELAKATDELSSRLGRAPR
                     VAELAPLMNLSEEEVVEAQVAANGYNSTSLDATIGGADSEDDDAALADLIGREDPAIEL
                     FEDFHTLAPLVEALDERDRVLLHLRFVEELTQTQIGERLGVSQMHVSRLLARSLNRLRE
                     GMVEPATDG"
     gene            complement(4057..4941)
                     /gene="thpD"
                     /locus_tag="K4902_RS33375"
                     /old_locus_tag="K4902_33375"
     CDS             complement(4057..4941)
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031436.1"
                     /locus_tag="K4902_RS33375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33375"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_073815455.1"
                     /sec_met_domain="PhyH (E-value: 1.5e-35, bitscore: 122.1,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAPTRPVDLYPTRGPKEELIGRKDPVVWSEPGTAGPFWARELE
                     EYDRDGFLTVDELVAPHEVDELRAELDRLVTDPAVRADERAIVEPSSQEIRSVFEVHRI
                     SEVFARLAEDPRLVGRARQILGSDVYVHQSRVNVKPGFGASGFYWHSDFETWHAEDGLP
                     RMRTVSVSIALTPNHTTNGSLMIMPGSHRTFLGCAGETPRDNYKKSLQMQDAGTPSDEA
                     LTTFAEACGIRHFTGPAGSATWFDCNALHGSGDNITPYPRSNVFLVFNSVENRPEAPFA
                     APVPRPSFIAARP"
     gene            complement(5001..5420)
                     /locus_tag="K4902_RS33380"
                     /old_locus_tag="K4902_33380"
     CDS             complement(5001..5420)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006375087.1"
                     /locus_tag="K4902_RS33380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33380"
                     /product="ectoine synthase"
                     /protein_id="WP_073815452.1"
                     /sec_met_domain="ectoine_synt (E-value: 9.6e-52, bitscore:
                     172.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFDELENTERHVKAASGTWESKRIVLARERVGFSLHETVLY
                     AGTETSMWYAHHVEAVVCTAGEAELTDHETGRTYTIVPGTMYLLDGHERHTLKVKRDFR
                     CLCVFNPPVTGREDHDENGVYPLLTEPDETVREES"
     gene            complement(5476..6741)
                     /gene="ectB"
                     /locus_tag="K4902_RS33385"
                     /old_locus_tag="K4902_33385"
     CDS             complement(5476..6741)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (27-364). E-value: 5.9e-73.
                     Score: 237.7. Matches aSDomain:
                     nrpspksdomains_K4902_RS33385_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031434.1"
                     /locus_tag="K4902_RS33385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33385"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_073815868.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.2e-76, bitscore:
                     255.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDIAAPSVFEALESEVRSYCRAWPVVFERASGSRLYDEHGRPYL
                     DFFAGAGSLNYGHNNPVLKRALLDYLADDGITHGLDMSTTAKRDFLETFHETVLEPRAL
                     PYKVMFPGPTGTNAVEAALKLARKVTGRQTVVSFTNAFHGMSLGSLAVTGNAAKRAGAG
                     VPLHHAFRMPFDDYLDGQVPDFLWFERLLGDSGSGLDHPAAVIVETVQGEGGINVARAE
                     WLRGLAELCRRHDMLLIVDDIQMGCGRTGDFFSFEEAGITPDIVTLSKSISGYGLPMAL
                     CLFRQELDVWEPGEHNGTFRGNNPAFVTATAALDAHWRDGALRERTLSRAGRVESALLD
                     LCGGDGRTGVSVRGRGLVWGLEFADGDRAAAVCRRAFETGLLLETSGPDGEVVKLLPPL
                     TATDEDLDEGLGILARSVRHTA"
     aSDomain        complement(5650..6660)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS33385_Aminotran_3.1"
                     /evalue="5.90E-73"
                     /label="K4902_RS33385_Aminotran_3.1"
                     /locus_tag="K4902_RS33385"
                     /protein_end="364"
                     /protein_start="27"
                     /score="237.7"
                     /tool="antismash"
                     /translation="FERASGSRLYDEHGRPYLDFFAGAGSLNYGHNNPVLKRALLDYLA
                     DDGITHGLDMSTTAKRDFLETFHETVLEPRALPYKVMFPGPTGTNAVEAALKLARKVTG
                     RQTVVSFTNAFHGMSLGSLAVTGNAAKRAGAGVPLHHAFRMPFDDYLDGQVPDFLWFER
                     LLGDSGSGLDHPAAVIVETVQGEGGINVARAEWLRGLAELCRRHDMLLIVDDIQMGCGR
                     TGDFFSFEEAGITPDIVTLSKSISGYGLPMALCLFRQELDVWEPGEHNGTFRGNNPAFV
                     TATAALDAHWRDGALRERTLSRAGRVESALLDLCGGDGRTGVSVRGRGLVWGLEFA"
     gene            complement(6820..7335)
                     /gene="ectA"
                     /locus_tag="K4902_RS33390"
                     /old_locus_tag="K4902_33390"
     CDS             complement(6820..7335)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059805.1"
                     /locus_tag="K4902_RS33390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33390"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_073815450.1"
                     /transl_table=11
                     /translation="MTAPVGGLDIGPASIDDGAELWRIARGSGELDLNSPYSYLLWCRD
                     FADTTAVARDASGRPVGFVTGYLRPDAPETLFVWQVAVEGSHRGSGVAGTLLDALTARV
                     AAEHGVSRVEATVTPGNLASDRLFRSYARRHGADLTQEVLFPSAAFPAAGHESEVLYRI
                     GPLGPRES"
     misc_feature    complement(7506..7523)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    complement(7546..7561)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            complement(7683..8486)
                     /locus_tag="K4902_RS33395"
                     /old_locus_tag="K4902_33395"
     CDS             complement(7683..8486)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009324198.1"
                     /locus_tag="K4902_RS33395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33395"
                     /product="endonuclease I family protein"
                     /protein_id="WP_073815449.1"
                     /transl_table=11
                     /translation="MSAAQTGRWKARAAAIAAVLVTLTLPTVTATPASATTTAYDSTYY
                     KNAIGKTGTSLKSSLHTIISSQSKISYDAVWNALKVTDQDPANSANVVLLYSGASRSKS
                     LNGGDVGDWNREHVWAQSHGSFGTSAGPGTDLHHLRACDVQVNSTRGNKDWDTGGSPVS
                     GASGSYTDSNSFEPRNADKGDVARMILYMAVRYEGDDAWADLEPNDSTTNGSVPFHGRL
                     SVLKQWNEQDPPSAFEERRNDVIFNTYQGNRNPFIDHPEWVEAIW"
     misc_feature    complement(8583..8598)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(8732..9196)
                     /locus_tag="K4902_RS33400"
                     /old_locus_tag="K4902_33400"
     CDS             complement(8732..9196)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031431.1"
                     /locus_tag="K4902_RS33400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33400"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_073815447.1"
                     /transl_table=11
                     /translation="MDRIDLHILRELQNDGRLSNQELAQRVGLSPSPCLRRVRQLEQDG
                     VIRGYRAIIDPDAVGRGFEVLVSVEVRRDRETVEAFEAALQDVPDVIEAYRLFGSPGCL
                     LRIAVADLAAYERLWIERLTTLAGVTEVNSQIIMKRVKEPKGMPVDVRGV"
     misc_feature    complement(9182..9195)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 agcgacgcgc cagcgggaca gccagcccca gagcagaccg gccacgaagc cgacgagcac
       61 cagcgcgccc agcagccacc agccgcggcc caggccgaac gaggccacgt ccgaggcggc
      121 cgccggaccg tcgacgacgt ccaccgtcag ctcgatgggc atgcccggcg tcgtcttgac
      181 cgacggggga gcggagaacg agttgctgac ctggagacag accgtctcgg cgaccggctt
      241 cgcgtccccc ggcccgtcgt cgcgttccgg cttcgggtag cgcaggcccg tcgagatcac
      301 gtcggtgcgt ccgtcgcccg cctcggagcc gcgcacgatc tcccggccgt gccgggtgac
      361 ggcccggagc agcacgccgt agtcgtcgtt gacggcccgg tcggccgaca cgctgacgga
      421 ggcgcgcagt tcctgccccg gcagcaggtc cacccggtac cagcggtgct caccgaagga
      481 ctcgcggtcg gtgtacaggc cgggcctgag ctgcggcgcg tcggcgcagc gcccggcgcc
      541 ctcggtggcc acgggcgtga cgaccgggtc ggcggcgcgg tcgaccagct ggcggacgcg
      601 gcgggagagg tcctcggtgc ggtggaccga ggtgtacgtc cctccggtcg cctccgcgat
      661 gcacgtgagc tgctgccggg tcttggcgtc cggcaccagg cccagggtgt cgatgacgag
      721 gtggatgccc ttcgccgcga tctcccgcgc cacctggcac gggtcgagcg gggcacaggt
      781 gtcctcgccg tccgtgatga gcacgatcct gcgggtggct tcgccgccct ccaggtcctc
      841 ggcagcgccg agcagcgccg ggccgatcgg ggtccagccc gtcggggcca gggtggccac
      901 cgcggtcttc gcctcggtcc ggtcgagggg gccgaccggg tagagctggc gggtgtcctt
      961 gcagccccgc ttgcggtccg gccccgggta gtcggcgccc agggtgcgga tgcccagccg
     1021 gacctcctcg ggcaccgcgt ccaggacctc gttgaaggcc tgcttggccg ccgccatccg
     1081 ggacttgccg tcgatgtcct tggcccgcat ggagccgctg acgtcgagga ccagctcgac
     1141 cttgggggat tccttcgcca ctggctcgtc ggcggccgcg ctcgtcggca gcagcgcgac
     1201 gctcagggcg gcgagcagcg cgcaggcccc ggtcgtcagc cgttttctcg tgatcatcgc
     1261 cggatcgtat tgatgatcct ccgacaatcc aaaacgagac cgccgacccc gcccgcgcca
     1321 ccgggaaccc gctggttaga gtggtgggcg gtcgcgccgc cgcaccaggc cgaggcgcga
     1381 gaccgggccg actgtcgacc acagggtccc gtacgaccac cagccagccc ccgtctcgtc
     1441 cggcccccag gccgccaccc cggaaacacc gcgccccatg agcaccgaca ccgccctgcg
     1501 ccccgagccc gccccgaccg ccgccgccgg ctccgacgag cgaagcccgc ggcggcgccg
     1561 gatggccggt cgcgcccccg cccggcccgc gcccgcggcc gccttccaca acgtcagcgc
     1621 ggccacggcc gccctgttgg gactcgtcgc gatcggcgcc gtgatccacg agccggtgct
     1681 cataccgccg ctcgccgcca gcgccgcact ggtgcactgc gcccccgccc ttccgctggc
     1741 ccagccgcgg agtgtggtcg tgggtcacct tctcggagcc gccgccggct acgcggtggc
     1801 cgccgtcgcc gcgcagggca gcgcgtgggc cgccgccctc gccgccggtc tcaccctcgc
     1861 cctgacgacg ctcgcccgga ccccgcactc gcccgcctgc gccaccgccg tcgtcatcgt
     1921 gctgcaggcg cccgcgccgg gcaggttcgt gccgctgctg ttcggatcca cggtcctgct
     1981 cgtggtgacc gccttcgccg cgtcccgcgt ccggcgcgga tcaccgaggt accccgccta
     2041 ctggtggtga gtccccgacc gcgatccggg gatgacccgc gaggacgggg gtagccgatg
     2101 cccatctcac ccactaggga ggcatcatgg gtctgggagt gtgcatcatc ctgatcgcgg
     2161 tcggggccat tctcacgttc gcgtccgact ggcaggtcga cggggtcaac ctcgacctgg
     2221 tcggtctgat cctcatggcc gtcggcatca tcggcacggc ggtctacacc agcattctga
     2281 ggcggcgtcg gctcgtggtc ccgccggcca ccaccacggt ggccgagaac gaccgacgag
     2341 accttctctg agacggtgtc cgtccgcacc ggacggcccc gcacacggaa gaggaggggt
     2401 ggccacgcga atcgcgtggc cacccctcct cttccgtgtg cgggtctctt ctccgtgtcc
     2461 gggtcaccgg tcgaccgcca ccgtcgcgtg gatggtcttg ccgtccgggc gggtgtcgac
     2521 ggacacctca cggcacagcc gcagcacgat cggccagccg aagccgccgg gacgcagctc
     2581 gtcgcggagc tggtagagcg gggagatccc actggcgtcg gccacggaca gggtcaccac
     2641 gtcgggtccg accctgatcc cgaagccggt gaccccaccc ccgtggcgga gcgcgttcgt
     2701 gaccaactcc gaggtgacga gaagcagatc ctcgacctgg gagggacgca gggggccgag
     2761 agccgcgagc gcgtggcgga cgaggccgcg cgcctgagcc ggtgtacgga ccggggacga
     2821 cccgccgtgg cccgtaccgt gcgggtccgc cgcggccgcc cgggacaggg tgtcgctccg
     2881 ggtgttcatc acgagtccct ttctgcctgg ttcgtcatca ggtgatggga ttcgcctgcc
     2941 cgttcctccc gccctgatgc acccgaccag gtgaggaagc ggccgaaacg gacgaggagt
     3001 gctcaaggga agccggggta cgagaaccgg gaccgctgaa ccgaccgcga gcaggaggag
     3061 gttcccgtgc ggacccagcc ggccgaggcg acgacgacgt acacgacgaa cggtacgcgt
     3121 gaggacctgc cggttctcga cgcgccgcac cgactcccgc cccaggacgc gcgggccctg
     3181 tcgaaggtgt tcttccgcga gctggcggca cgggaggagg gcaccgcgga gcaccagtac
     3241 gtgcgcaaca cgctgatcga gatgaacatg tcgctggtgc ggtacgcggc ggggcggttc
     3301 cgtgcgcggg gcgacgagat ggaggacatc gtccaggtcg gcatggtcgg cctgatcaag
     3361 gcgatcgacc gcttcgacct ctcgcgcgag gtcgagttcg ccaccttcgc cgtgccctac
     3421 atcgtggggg agatcaagcg gttcttccgc gacaccacct gggcggtgca cgtcccccgc
     3481 cggctccagg aggcgcgggt ggagctcgcg aaggcgaccg acgagctgag ctcccggctc
     3541 ggccgggctc cccgggtcgc ggagctggct ccgctcatga acctgtccga ggaggaggtc
     3601 gtcgaggccc aggtggccgc caacggctac aactccacgt ccctcgacgc cacgatcggc
     3661 ggcgccgaca gcgaggacga cgacgccgcg ctggccgacc tcatcggccg ggaggacccg
     3721 gcgatcgagc tcttcgagga cttccacacc ctcgccccgc tcgtggaggc cctggacgag
     3781 cgcgaccggg tgctgctgca cctccgcttc gtcgaggagc tgacccagac gcagatcggg
     3841 gagcggctcg gcgtctcgca gatgcacgtc tcgcgcctcc tcgcccggag cctgaaccgg
     3901 ctgcgggagg gcatggtcga gccggccacc gacggctgag ggaccagcga gccgagaggg
     3961 gcccggccat caggccgggc ccctctctcg gtctcatctc ccggtctcag cggaccgcgt
     4021 ccgggaacgt gtcggcgcgc tcccgagcgg gtgtcctcac gggcgcgccg cgatgaagga
     4081 gggccgcggg accggggccg cgaagggcgc ctcgggccgg ttctcgacgc tgttgaacac
     4141 gaggaacaca ttgctccggg ggtacggggt gatgttgtcg cccgaaccgt gcagggcgtt
     4201 gcagtcgaac caggtggcgg accccgcggg accggtgaag tggcggatgc cgcaggcctc
     4261 ggcgaaggtg gtcagcgcct cgtcggacgg ggtcccggcg tcctgcatct gcagcgactt
     4321 cttgtagttg tcccgaggcg tctcaccggc gcagcccagg aaggtgcggt gcgagcccgg
     4381 catgatcatc aggctgccgt tggtggtgtg gttcggggtc agcgcgatcg agaccgagac
     4441 ggtccgcatc ctcggcaggc cgtcctcggc gtgccaggtc tcgaagtcgg agtgccagta
     4501 gaagccgctg gcgccgaagc cgggcttgac gttgacccgc gactggtgga cgtagacgtc
     4561 cgagccgagg atctggcggg cgcgccccac gagccgcggg tcctcggcca gccgggcgaa
     4621 gacctcgctg atccggtgca cctcgaagac ggaacgtatc tcctgggagc tgggttcgac
     4681 gatcgcccgt tcgtccgccc gtacggcggg atcggtgacg agccggtcca gctcggcccg
     4741 gagttcgtcg acctcgtgcg gggcgaccag ctcgtccacg gtgaggaaac cgtcgcggtc
     4801 gtactcctcc agttcacggg cccagaacgg ccccgccgtg ccgggctcgg accacaccac
     4861 ggggtccttg cgcccgatca gctcctcctt ggggccacgg gtggggtaga ggtcgacggg
     4921 acgggtgggt gcggaggtca tgagggagcg tgccttcctt cctgtgcggg ttcgttcggg
     4981 cgtccggtgt cgtgcccggc tcagctctct tcgcggacgg tctcgtccgg ctcggtgagc
     5041 agggggtaga cgccgttctc gtcgtggtcc tcgcggcccg tgacgggcgg gttgaagacg
     5101 cagaggcagc ggaagtcccg cttgaccttg agggtgtggc gctcgtgccc gtcgagcagg
     5161 tacatcgttc cgggcacgat cgtgtacgtg cggccggtct cgtggtcggt gagctcggcc
     5221 tcgcccgccg tgcagacgac ggcctcgacg tggtgcgcgt accacatgga cgtctcggtg
     5281 cccgcgtaca gcacggtctc gtggagggag aagcccaccc gctcgcgggc gaggacgatg
     5341 cgcttgctct cccacgtgcc cgaggcggcc ttcacgtgcc gctcggtgtt ctccagctcg
     5401 tcgaaggaac ggacgatcat ggggtgttgc ctttcggtgc gtgctcgatg cgtgtgcggt
     5461 ggcggctctg cggggtcagg cggtgtggcg cacggagcgg gccaggatgc cgagaccctc
     5521 gtcgaggtcc tcgtccgtcg cggtcagcgg cggcagcagc ttgaccacct cgccgtcggg
     5581 acccgacgtc tccaggagca gcccggtctc gaacgcgcgt cggcacacgg ccgcggcccg
     5641 gtcgccgtcg gcgaactcca ggccccagac caggccgcgg ccgcggacgg agacgccggt
     5701 ccgcccgtcg cccccgcaca ggtcgaggag ggcgctctcc acccggccgg cccggctcag
     5761 ggtgcgctcg cgcagggcgc cgtcgcgcca gtgggcgtcg agggcggccg tggcggtgac
     5821 gaaggcgggg ttgttgccgc ggaaggttcc gttgtgctcg ccgggctccc acacgtcgag
     5881 ctcctgccgg aacaggcaca gggccatcgg caggccgtat ccgctgatgg acttggacag
     5941 ggtgacgatg tcgggcgtga tgcccgcctc ctcgaaggag aagaagtcgc cggtgcgccc
     6001 gcagcccatc tggatgtcgt cgacgatgag gagcatgtcg tggcggcggc agagctccgc
     6061 gagcccgcgc agccactcgg cccgggcgac gttgatgccg ccctcgccct ggacggtctc
     6121 gacgatcacg gccgccgggt ggtcgagacc cgaaccggag tcgcccagga gacgctcgaa
     6181 ccagaggaag tcggggacct gcccgtcaag gtagtcgtcg aagggcatgc ggaaggcgtg
     6241 gtgcagcggg acgcccgctc cggcgcgctt ggcggcgttg ccggtgacgg ccagcgaacc
     6301 gagcgacatg ccgtggaagg cgttggtgaa ggagacgacg gtctggcgcc cggtgacctt
     6361 gcgggcgagc ttcagcgcgg cctccacggc gttggtgccg gtggggccgg ggaacatcac
     6421 cttgtagggc agggcgcggg gttcgaggac cgtctcgtgg aaggtctcca ggaagtcgcg
     6481 tttggccgtc gtcgacatgt cgagaccgtg ggtgatcccg tcgtcggcga ggtagtcgag
     6541 gagggcccgc ttgaggaccg ggttgttgtg gccgtagttc agcgagcccg cgccggcgaa
     6601 gaagtcgagg tacggacgcc cgtgctcgtc gtacagcctg ctgccgctgg cgcgttcgaa
     6661 gacgaccggc caggcgcggc agtagctgcg gacctcggac tcgagggcct cgaagacgga
     6721 gggggcggcg atgtcgatca gggtcacgga gtctcttctc caggtgtggt tcgggaacgt
     6781 ggtgcgtgcg gacgacggct caggacgcgg tgggccggct caggactccc ggggcccgag
     6841 gggaccgatg cggtacaaca cctcggactc gtgtcctgcc gcggggaagg cggctgaagg
     6901 gaacagcacc tcctgcgtca ggtccgcgcc gtgccggcgc gcgtaggacc ggaacagccg
     6961 gtcggaggcg aggttcccgg gggtgacggt ggcctcgacg cggctgactc cgtgctcggc
     7021 cgcgacccgt gcggtcaggg cgtcgagcag ggtcccggct accccgcttc cgcggtgtga
     7081 accctccacg gcgacctgcc agacgaagag cgtctccggc gcgtcgggcc gcaggtagcc
     7141 ggtgacgaag ccgaccgggc gtccggaggc gtcacgggcg acggcggtcg tgtcggcgaa
     7201 gtcgcggcac cacagcaggt agctgtaggg cgagttgagg tcgagttccc ccgatccgcg
     7261 ggcgatccgc cagagctcgg cgccgtcgtc gatggaggcg gggccgatgt cgaggccgcc
     7321 gaccggggct gtcatatggg ctgtggtcat gggggccgaa gctacccagt ggatccggga
     7381 acttcctcga cccaagggct tgttctggac aggagtccgt gataggtgct ccggtgtccc
     7441 gtgaggctgg aatgcaagct tcctcacatg aaaaaggcgt acggaacggg acatagtcac
     7501 cgtttataac ggacacataa cgtctccggg gtgtgtcccg cgcctgtgcg aagaccgtga
     7561 gaacatccgc catttggcgt ttgaacgtgc cgcgagcggt caggatcttg ggtcgacatg
     7621 cgcggagccg ggcccggtgc gcgcaccggg cccggctccg tccgatctcc gacctggtcg
     7681 gactaccaga tcgcctcgac ccactccggg tggtcgatga acggattccg gttcccctgg
     7741 taggtgttga agatgacgtc gttgcggcgc tcctcgaaag cgctcggcgg gtcctgctcg
     7801 ttccactgct tgaggaccga gaggcggccg tggaagggga cgctgccgtt ggtggtcgag
     7861 tcgttcggct ccaggtcggc ccaggcgtcg tcgccctcgt agcgcacggc catgtagagg
     7921 atcatccggg ccacgtcgcc cttgtccgcg ttccgcggct cgaacgagtt gctgtccgtg
     7981 tagctgccgg aggcgccact caccgggctg ccgccggtgt cccagtcctt gttcccccgg
     8041 gtgctgttga cctggacgtc acaggcgcgc agatggtgga ggtcggtgcc cgggccggcc
     8101 gaggtgccga agctgccgtg ggactgggcc cacacgtgct cgcggttcca gtcgcccacg
     8161 tcacccccgt tgaggctctt gctgcgcgag gcgccgctgt acagcaggac gacgttggcg
     8221 gagttggcgg ggtcctggtc ggtgaccttc agggcgttcc agacggcgtc gtacgagatc
     8281 ttgctctggc tgctgatgat cgtgtgcagc gaggacttga ggctcgtacc ggtcttgccg
     8341 atcgcgttct tgtaataggt gctgtcgtac gcggtggtcg tggcgctcgc gggagtcgcg
     8401 gtgaccgtcg gaagcgtgag ggtgacgagg acggcggcta tcgctgccgc tcgcgccttc
     8461 cagcggcctg tctgtgcagc ggacatgggg ggtgcccttt cccggggacg tcacgcgaag
     8521 ggcgcggagc ccgctcaacg gctccgcgtt ctacgcgtgt tgcgtggtgg tagccgggag
     8581 cgtcgcacag ccgtgcggaa ggccgtgtat ccatgaggag gcgattccgt gacgttctcg
     8641 catacggctc ccccctgacg gccgctcagt cccgatcccg gggtgaccgg tgacggtcga
     8701 tgccccttcg cccccgatcc accgacactc cctagacgcc ccggacgtcc accggcatcc
     8761 ccttcggctc cttgacgcgc ttcatgatga tctgcgagtt gacctcggtg accccggcca
     8821 gcgtcgtcag gcgttcgatc cacagccgtt cgtacgccgc gagatcggcc accgcgatcc
     8881 tgaggaggca tccggggctg ccgaacagcc ggtacgcctc gatgacgtcc ggcacgtcct
     8941 gcaaggccgc ttcgaaggcc tccaccgtct cccggtcgcg ccgcacctcc accgagacga
     9001 ggacctcgaa gccgcgcccc accgcgtccg ggtcgatgat cgcccggtag ccccggatca
     9061 ccccgtcctg ctccagctgg cgcacccggc gcaggcaggg cgacgggctc agcccgacgc
     9121 gctgtgccag ctcctggttg ctcagtcggc cgtcgttctg cagctcacgc aagatatgga
     9181 gatcgattcg gtccatggcg caattatcta ccacgatgaa acattcggcg gggtgatttc
     9241 gcaatcgcct tgcgcgacct ctgccttatc gttgcgagac aggagattct ggtaccgagt
     9301 gagggtgacg ggcatgaagc ggacgaacga cgggggagcg cgccggatcg tcgtcatcag
     9361 caccggcggc acgatcgcga gccgctggca gggcaccggc tacgccgccg acgcctcggg
     9421 cgacgacgtc ctcgccaccg cccccctccc cgagggcgtc accgtcgagg tcgtcgacct
     9481 gttcaacgtc aacagctccc gcatgaccgc ggcccatcag ctggccctcc tgcgcaccgt
     9541 ccacgagacc ctcgccgacc ccggcgtcga cggcatcgtg atcacccacg gcaccgacac
     9601 ccttgaggag accgccttcc tcctggacct ccaccacacc gacgtccgcc cggtcgtcct
     9661 caccggcgcc cagcgcccct tcggcaccgg cgacggggac ggccccggca acctctacga
     9721 cgccctccag gtcgcctcat ccgtcagcga cctcggcgtc ctcgtcgtct tcgacggccg
     9781 ggtccacgcc gcccgcggca ccgtcaagag ccagaccctg gccgccgacg ccttctccga
     9841 cccgtcggcc gagcgtctgg ggcgcgtcgg gttctcccgc gtcgacatcg agcgccgccc
     9901 ggagcgcccc gcgccgctgc cgctccccgt cgccgcccac accgcgaccc ccggcgttcc
     9961 cgggcccgtc ccgctgcccc gggtcgacat cgtcagccac cactccgacg gcgacccgtt
    10021 cctgttgaac gcggccgtcg ccgccggtgc gcggggcatc gtcctcgaag cgaccggcgc
    10081 gggcaacgcc acccccgaga tcgccgccgc cgtggcggac gccgtcgccc agggggtcct
    10141 cgtcgccgtg accacccgcg tccccgcggg gccgctcgcc gagatctaca ccggcggcgg
    10201 cgcggtggac ctggtcgccg ccggtgcgct gctcaccggc acgctccgcg ccgcccaggc
    10261 acggatcgcc gtcctcgcga cgctcctcgc cgacggcggc ccgggcgacc ccgcccgcag
    10321 cgccgctctc ctgcggcgcc tcctcgaagg gccggtccgc gcggaacccg cgctcgccac
    10381 cggcgcctcc cgatcggcct cggcggtcgc cgcccgcacc
//
