LOCUS       NZ_JAIHBQ010000001     23517 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7280762
            Orig. end                         :: 7304279
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23517
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23517
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23517
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13517](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13517)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    140..154
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            484..1305
                     /locus_tag="K4902_RS32975"
                     /old_locus_tag="K4902_32975"
     CDS             484..1305
                     /EC_number="2.4.2.28"
                     /GO_function="GO:0017061 - S-methyl-5-thioadenosine
                     phosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143990.1"
                     /locus_tag="K4902_RS32975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_32975"
                     /product="S-methyl-5'-thioadenosine phosphorylase"
                     /protein_id="WP_221747297.1"
                     /transl_table=11
                     /translation="MSDPSGTPPQADIAVIGGSGFYALLESVERVEVTTPYGAPSDAVS
                     VGTVGDRRVAFLPRHGSRHELPAHRINYRANMWALRSLGVRQVLAPCAVGSLRGSLGPG
                     SVVLPDQLVDRTAGRVQTYYEHGAVHVSFADPYCASGRAAVLKAAGETGADVHDGGVMV
                     VVEGPRFSTRAESRWYASAGWSLINMTGHPEAVLARELALCYTSIALVTDYDAGVEHGE
                     GVSQDEVFRVFAANVEHLKGLVLKTVGVLDRERACACATALDGMDLPFELP"
     gene            complement(1386..1898)
                     /locus_tag="K4902_RS32980"
                     /old_locus_tag="K4902_32980"
     CDS             complement(1386..1898)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237913.1"
                     /locus_tag="K4902_RS32980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_32980"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_221747298.1"
                     /transl_table=11
                     /translation="MTTPPRTAIALAPMTDDHAPAVMAIYQQGIDEGNATFETVAPPWS
                     AFDTAKLPAHRLVALDRHRKVVGWTAVSRVSARPAYAGVVEHSVYVCPTARGAGVGRAL
                     LDALIVSTERAGIWTIQAGIFPENAASLALHESVGFRVLGRRERVARHHGVWRDVLLVE
                     RRSPVVE"
     gene            complement(2016..3170)
                     /locus_tag="K4902_RS32985"
                     /old_locus_tag="K4902_32985"
     CDS             complement(2016..3170)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015715.5"
                     /locus_tag="K4902_RS32985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_32985"
                     /product="permease"
                     /protein_id="WP_073815620.1"
                     /transl_table=11
                     /translation="MDELRALGLFILFEVLHYLPWFLVAIVLGIAVQRLSIDVVARRSF
                     AHGRRGVLGIAVVTAIGAFSPFCSFTVIPLIRRFLIAGVPLSAVMAFWIASPSMDPEIY
                     ALSAAQLGLPIATARLIGALVLSFGAGLIVLALERRGRFADPLLDSTEEKTPAKTCSQE
                     TVAVPETACSTARVTVPETACSTAKVTVPEPVTVGGGAGDGASEGGCGGSAQEPAPAAG
                     GCSTAARNDTDDDGTPWRVLVRRDIKNLRAGEILKEIVSDSLILGKWLLLAIVLEALIV
                     RYVPTDVVSGILGTDGVLSVLVAGLISVPLYLNGVGAIPVVEGLLDQGMVAAAGVTFLL
                     GGAITTIPAMVAVKSVVKAKVFAFYLAVGLLGSVGIGLVSLAIL"
     misc_feature    complement(3267..3284)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    3544..3560
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.78"
                     /tool="antismash"
     gene            3570..3899
                     /locus_tag="K4902_RS32990"
                     /old_locus_tag="K4902_32990"
     CDS             3570..3899
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018382014.1"
                     /locus_tag="K4902_RS32990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_32990"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_229902042.1"
                     /transl_table=11
                     /translation="MSGTMNAQLIDRSTAESYATWFKALSDPTRVQILNLLALATGPMS
                     VGEIVDRMGVGQSTVSHHLKLLADVRFVLRERQGTSMLYSINVACVACFPSAADAVMGR
                     PAASA"
     gene            3911..4306
                     /locus_tag="K4902_RS32995"
                     /old_locus_tag="K4902_32995"
     CDS             3911..4306
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018531556.1"
                     /locus_tag="K4902_RS32995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_32995"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_073815617.1"
                     /transl_table=11
                     /translation="MTESTPHISGPRAAACCPPLVTAALSEGDAETMAAMFKALADPVR
                     LRLLSRVASHPSGEACVCDIADVGVSQPTVSHHLKKLREAGLLTSERRGTWVYYRPAPG
                     VLASLGAFLADTEKAGQEEISMEAQVS"
     gene            complement(4371..4733)
                     /locus_tag="K4902_RS33000"
                     /old_locus_tag="K4902_33000"
     CDS             complement(4371..4733)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005473395.1"
                     /locus_tag="K4902_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33000"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_073815614.1"
                     /transl_table=11
                     /translation="MSNVKSLPLVEPEIAPCCPPLDERPLTAEEAERTAVMFKALGDPV
                     RLRLFSSVASHEGGEACVCDISDVGVSQPTVSHHLKKLKEAGLLSSERRGTWVYYRVEP
                     TVLAAMGALLTQAASA"
     misc_feature    4742..4757
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            4866..6233
                     /locus_tag="K4902_RS33005"
                     /old_locus_tag="K4902_33005"
     CDS             4866..6233
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004924293.1"
                     /locus_tag="K4902_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33005"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_073815612.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-12, bitscore:
                     44.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTATDQLPVVVVGAGPAGLAAAAHLVDRGLEPLVLEAGTRAGA
                     AVREWSHVRLFSAWGEVTDPVAERLLAPTGWVKPDPDTYPTGGDWAAAYLQPLADVLGD
                     RIRLDARVTGVSRTGRDRVVDADREQQPFTVHVRYGDGREERVLARAVIDASGTWTAPG
                     PAGGDGLPALGERAAADRISYRVPDLKDPAVRARYAGRRTAVIGSGASAFTALASLAAL
                     AKSQGGEATRATWILRRGISGTTYGGGGADQLPARGALGLAAKAAVDEGYADAVTGFRT
                     DAIEREGERLVLVAEDGRRLDPVDEVIVLTGFRPDLTFLGELRLGLDERLQAPVGLAPL
                     IDPNQHSCGTVYPHGVTELSHPEEGLYLVGMKSYGRAPSFLALTGYEQVRSVVAAIAGD
                     RESAERVELVLPETGVCGGAGLFDQPADTTTDGGGCCATPTALQIGFGAPAASGAR"
     gene            6266..6733
                     /locus_tag="K4902_RS33010"
                     /old_locus_tag="K4902_33010"
     CDS             6266..6733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852629.1"
                     /locus_tag="K4902_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33010"
                     /product="ArsI/CadI family heavy metal resistance
                     metalloenzyme"
                     /protein_id="WP_073815609.1"
                     /transl_table=11
                     /translation="MSRVQLALRVPDLAASVAFYTKLFGSEPAKLREGYANFAIAEPPL
                     KLVLVEGTENEDTRLDHLGVEVDTTEAVHAATARLGEAGLPTTEENDTTCCHALQDKVW
                     VHGPGREPWEVYVVKADADTLTRQQGSTCCAGPAAGADDEVTEPVAAGGCC"
     gene            6741..7958
                     /locus_tag="K4902_RS33015"
                     /old_locus_tag="K4902_33015"
     CDS             6741..7958
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844281.1"
                     /locus_tag="K4902_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33015"
                     /product="MFS transporter"
                     /protein_id="WP_073815607.1"
                     /transl_table=11
                     /translation="MADLHTRGAATGTGDRSRPRAVLPALCVTQITGWGIVHYAFPVLN
                     PQITADSGWSTGATTAAFSLALVVSGIAGIRVGRIIDQRGPRMVMTAGSAAGVAGLAIV
                     ALAPNLPVFFAGWTLAGLSMAATFYQPAFAALTRWWAPDHVRALTVVTLAGGLASTVFA
                     PLTAVLADHLSWRGTYLVLAAILAVVTLPAHALALRAPWPPTPPAPDGTDADPGTVARS
                     RPFVLLAVAFTISAFAMYAVVVTLVPLLLERGYTTAQAAWALGLGGAGQTLGRTLHAPL
                     ARRTGTTVRTTTLLALGALTTAALAVTPGPYGLVIAVSIAAGTVRGNLTLLQATAITDR
                     WGARHYGRLSGLLSAPATTAAAVAPFAAALLAVPLGGYPELFGALAGLGLAAALVAMAS
                     SGRTGR"
     gene            8163..8807
                     /locus_tag="K4902_RS33020"
                     /old_locus_tag="K4902_33020"
     CDS             8163..8807
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944450.1"
                     /locus_tag="K4902_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33020"
                     /product="GAP family protein"
                     /protein_id="WP_073815604.1"
                     /transl_table=11
                     /translation="MVLDLVVIGTAITLGPLHNSAFILLLSSRRGVRKGLAFLLSWLAN
                     LVTVVAVVLLLTGGQPPARHSVPSTAAIAAKLAIGLALVVYGEYRRRRPPRPHGPPRWA
                     ARIDDASTVTAAGLAWLLQPWGLVGAGAATALDANLSTAAAWFALTAYCLLATLSLIVM
                     EMYVVWVPAVAHARLNALRTSLAQHQEQLIVTLALVAGVWLTARSIYELVT"
     gene            complement(8903..9187)
                     /locus_tag="K4902_RS33025"
                     /old_locus_tag="K4902_33025"
     CDS             complement(8903..9187)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS33025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_33025"
                     /product="hypothetical protein"
                     /protein_id="WP_221747299.1"
                     /transl_table=11
                     /translation="MSATTSAPASSSPSASVTASVTGTVTGTASATVAAAPPSSGSTSA
                     AAPGNDMTHLASPGPSSRLPLVLGFCGVLLGAGALLTVRSRGKVRRRTG"
     gene            9307..9954
                     /locus_tag="K4902_RS33030"
                     /old_locus_tag="K4902_33030"
     CDS             9307..9954
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013625.5"
                     /locus_tag="K4902_RS33030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33030"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_221747300.1"
                     /transl_table=11
                     /translation="MSALLPQCGGRSRCACLTPREAAGTYQGETRGEFDQEWVRPYLPA
                     QDAVPDGTTETWVIPRVPREAELPPEPGGTLPPVVMTQAYRRGREAPKRRRAVHLTAAL
                     AALAGSAAIAGAYAFSQGSDPNDMAGPQPASGLEVLDGGQEPLVSPPGSQANTELQQRL
                     RQLGLWPHPLRGHFNRHLQDAVQRFQAEHGISDDSPGVYGPATRHQLESMTS"
     gene            complement(10001..11047)
                     /locus_tag="K4902_RS33035"
                     /old_locus_tag="K4902_33035"
     CDS             complement(10001..11047)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840879.1"
                     /locus_tag="K4902_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33035"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_073815892.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-41, bitscore:
                     140.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTAPAGPDPSARDDLRALLAQVESGLRAFLSQERFRWSRPDGR
                     GAEPALAVAELVGAGGKRLRPRFLLSGYLAAGGEPGEAPVRAAMALELLHVSALIHDDV
                     MDDADRRRTRPTVHARHAEIHRDREWFGEPRRYGESVAILAGDLAWAYADYLMAGTSPA
                     VAREWFDLKSELIAGQAMDVTAAAELTPDAELARHIALVKSGRYTVHRPLTLGALLAGR
                     ADLAAAFQPYGEALGEAFQLRDDLIDAFGDGAVSGKPVRQDFGRGKMTLLLALAMRSDE
                     RIRALVERGEVELLRERLSGTAVHARIEARIEQLVERACASLAVAALPPEWRRELTSTA
                     SSAAYREA"
     gene            complement(11083..12429)
                     /locus_tag="K4902_RS33040"
                     /old_locus_tag="K4902_33040"
     CDS             complement(11083..12429)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="K4902_RS33040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33040"
                     /product="cytochrome P450"
                     /protein_id="WP_221747301.1"
                     /sec_met_domain="p450 (E-value: 2.3e-75, bitscore: 252.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTYDTLSPALAGGLPLLGHAPWLALRPLDFVERLRDHAPVALFR
                     IGTRSAYMVSSGELMKDLLITHQSKFEKGGPLFEQATKLLGNGLAASNGEFHLRQRRLS
                     QPAFHHSRMGVYARAALDAAVVVSGSWRDGEVVDLGRALNDTTMDILARTLFSSLTAEA
                     AAEIRRCLPALVAGVGRRAFIPVEFVHRLPLPVNRREAESLRRLYEVVDGIISDYRASD
                     LDQDDLLSTLMLARDEQTGEGMTTEQLHDEIRSMMVAGTETSATLLLWAFQVLAARPDV
                     ERRVHAELDEVLDGRPVGYADLPSLAYLGRVVQELLRMYPTGWILTRRATSSVVLGGHR
                     IPEGADVFFSPYALHRDPAVFADPGRFDPDRWLPERAATVPRHAYLPFGAGVRKCIGES
                     LAYAEITLILASLMGRWRMRSVTGRPPRPVAGSTLRPKESLMRVEERRR"
     gene            complement(12426..13517)
                     /locus_tag="K4902_RS33045"
                     /old_locus_tag="K4902_33045"
     CDS             complement(12426..13517)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="K4902_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33045"
                     /product="terpene synthase family protein"
                     /protein_id="WP_221747302.1"
                     /sec_met_domain="T1TS (E-value: 9.1e-54, bitscore: 182.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIDVDFSLPFAAGRPLPRQVERAGRRGVDWATEHRLIRPTEAAI
                     GYFLDMRLADVSTGFCPEADGPDLDVMTDVITWTAVCDDFFDGPAGDDPRFAEAAVLAL
                     SSVTGSAGPARVPPGIEALAGATADLWARMRAPMSPAWQARAARNWRRFLRSFLAEADA
                     RRARTVPDLAGYLALRRETMAMYVYLDAAERTGRYEVPERVLTDPVLLRLSTLQIDILA
                     HCNDVHSLEHEEARGDTHNLVLVLEQESGRSRDEVIEEIRDRVGRLVVRFQRAADDIPS
                     LCDRLSCDPAERAATYRHLTALTRQLRVTYDWSLATTRYTRRAASGRRPEYLKASTGRS
                     GAVAGRAGLARTGLVPQQIGEAR"
     gene            complement(13521..13814)
                     /locus_tag="K4902_RS33050"
                     /old_locus_tag="K4902_33050"
     CDS             complement(13521..13814)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137603.1"
                     /locus_tag="K4902_RS33050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33050"
                     /product="Dabb family protein"
                     /protein_id="WP_073815591.1"
                     /transl_table=11
                     /translation="MIRHVVLFKFKPGIDWNDPRALEAERSTAKVGGEVPELRAWRYGR
                     NVSTREIAYDFLAEGVMDDMEAVERYIVHPFHQESVRQWREISDWVIVDVED"
     gene            complement(13852..14160)
                     /locus_tag="K4902_RS33055"
                     /old_locus_tag="K4902_33055"
     CDS             complement(13852..14160)
                     /EC_number="5.4.99.5"
                     /GO_process="GO:0046417 - chorismate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01808.1"
                     /locus_tag="K4902_RS33055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33055"
                     /product="chorismate mutase"
                     /protein_id="WP_221747303.1"
                     /transl_table=11
                     /translation="MTETSHSTTGIDQERVAIDGLDGHIIELLARRARISARIQQSRMN
                     AGGPRTELSREMDVLARYRDGLGPYGTQVAMSILKLCRGAGPQELLALTAEATDRPA"
     gene            complement(14153..15343)
                     /locus_tag="K4902_RS33060"
                     /old_locus_tag="K4902_33060"
     CDS             complement(14153..15343)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-382). E-value:
                     1.7e-61. Score: 200.3. Matches aSDomain:
                     nrpspksdomains_K4902_RS33060_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741231.1"
                     /locus_tag="K4902_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33060"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_221747304.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.9e-59, bitscore:
                     200.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTEFAQRLQDLPRSSFATTVGRIDQLVAAGEDVVNLCQGNPDLP
                     TPPHIVEALRREVLDPGTHRYPSFSGLLELKAAIAQWYEANHQVGLDPETEVAILFGAK
                     AGLVEISQCFLNPGDVCLMPDPAFPDYWAGVVLARAHMHPLPLLRENGFLPDYTALDAA
                     TCERAKLMFLNYPNNPTSVTAPPEFYEDTVRFAAEHDVIVASDFAYGALGFDGQVPASF
                     LATEGAKDVGVEFISLSKMFNMAGWRIGAVVGNPDVVAAINLIQEHYYVSLPPFIQRAG
                     VAALSGPQDCVRELTAIYERRRDIFVAGVREAGHRIDEPRSIFAWLPIPGGGSSVAFAD
                     ELLTRAKVAVAPGRWFGAHGEGYVRVSLLAPEDRLREAVARLSAFWNATEEGTPHD"
     aSDomain        complement(14198..15247)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS33060_Aminotran_1_2.1"
                     /evalue="1.70E-61"
                     /label="K4902_RS33060_Aminotran_1_2.1"
                     /locus_tag="K4902_RS33060"
                     /protein_end="382"
                     /protein_start="32"
                     /score="200.3"
                     /tool="antismash"
                     /translation="DVVNLCQGNPDLPTPPHIVEALRREVLDPGTHRYPSFSGLLELKA
                     AIAQWYEANHQVGLDPETEVAILFGAKAGLVEISQCFLNPGDVCLMPDPAFPDYWAGVV
                     LARAHMHPLPLLRENGFLPDYTALDAATCERAKLMFLNYPNNPTSVTAPPEFYEDTVRF
                     AAEHDVIVASDFAYGALGFDGQVPASFLATEGAKDVGVEFISLSKMFNMAGWRIGAVVG
                     NPDVVAAINLIQEHYYVSLPPFIQRAGVAALSGPQDCVRELTAIYERRRDIFVAGVREA
                     GHRIDEPRSIFAWLPIPGGGSSVAFADELLTRAKVAVAPGRWFGAHGEGYVRVSLLAPE
                     DRLREAVARL"
     gene            complement(15333..16637)
                     /locus_tag="K4902_RS33065"
                     /old_locus_tag="K4902_33065"
     CDS             complement(15333..16637)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741232.1"
                     /locus_tag="K4902_RS33065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33065"
                     /product="MFS transporter"
                     /protein_id="WP_260462068.1"
                     /transl_table=11
                     /translation="MSDRSTDAEHPGGFPVLTVLALMAGIFAVGSEELVVSPLLVNMAD
                     SFGATVALMALSVSVYGIGTAVGALLFAPLGDRVSRRLSLVVGMVMFVLGTVLCASATG
                     PGTFFTGRVLAGLATGAFVPTAYAFVGDQIPYRHRARAMGILVSSWSLSLVLGVPLGSF
                     VGEWAGWRWTFGLLAILGALVVFVLLMVGGGKPARDQGDPAAAEKSAEPSRGGWVRSTA
                     QAFRGPRVTVYVLATFLNMFAFYGMYTFLGSALQYRFGSGSSMTGLMILLYGLGFATSF
                     LTGRWADELGKEKVLVALLAGLVPALVAIPFVTRWTALLVVCLFLWGAMQSLVVTLLST
                     LLSECSPQHRGAILALYSLATNLGVALGAALLGPLFTAYGFSAVGWVCAGITLIAFGLS
                     GWVYRRRHEGSPDGAGVPGKDKDTTHEARVAAHED"
     gene            complement(16677..17426)
                     /locus_tag="K4902_RS33070"
                     /old_locus_tag="K4902_33070"
     CDS             complement(16677..17426)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-155). E-value: 5.6e-12. Score:
                     37.9. Matches aSDomain:
                     nrpspksdomains_K4902_RS33070_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741233.1"
                     /locus_tag="K4902_RS33070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33070"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_073815582.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-37, bitscore:
                     127.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.7e-33, bitscore:
                     114.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEDKVVVVTGAASGIGRQTAIEFARQGAKVVVADIDEKGGTEVV
                     AALRNDGHDAVFVTTDLTVEADCRNLIAAAVDGFGRLDVLVNNAGIEITTPFHEMSEHE
                     WDRLVDTNLKSMFLCSKHALREMITATSGAIVNVCSVSGLVAWPGIAAYNSTKGGVMML
                     TKSLAVDYAKYNIRANCVCPSIIDTPMTDVSNGHDADIKAEKAKLNPIGRLGTPEDVAN
                     AILFLASDKSSFITGSALTVDGGYTAI"
     aSDomain        complement(16962..17411)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS33070_PKS_KR.1"
                     /evalue="5.60E-12"
                     /label="K4902_RS33070_PKS_KR.1"
                     /locus_tag="K4902_RS33070"
                     /protein_end="155"
                     /protein_start="5"
                     /score="37.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVVVTGAASGIGRQTAIEFARQGAKVVVADIDEKGGTEVVAALRN
                     DGHDAVFVTTDLTVEADCRNLIAAAVDGFGRLDVLVNNAGIEITTPFHEMSEHEWDRLV
                     DTNLKSMFLCSKHALREMITATSGAIVNVCSVSGLVAWPGIAAYNS"
     CDS_motif       complement(17328..17408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4902_RS33070_0001"
                     /evalue="9.30E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="K4902_RS33070"
                     /protein_end="33"
                     /protein_start="6"
                     /score="21.5"
                     /tool="antismash"
                     /translation="VVVTGAASGIGRQTAIEFARQGAKVVV"
     gene            complement(17441..18223)
                     /locus_tag="K4902_RS33075"
                     /old_locus_tag="K4902_33075"
     CDS             complement(17441..18223)
                     /NRPS_PKS="Domain: PKS_KR (3-115). E-value: 6.4e-07. Score:
                     21.4. Matches aSDomain:
                     nrpspksdomains_K4902_RS33075_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="K4902_RS33075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33075"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_073815579.1"
                     /transl_table=11
                     /translation="MTRVAIILGAGRGIGRATALHLSAKGYTTVLCARGSEDLEKVAAE
                     ANAGTGDGGRSAYVLPGDVTSPSFREELVGDVERRFGRIDVLINNAPGPPPGHFDDILV
                     DDVRSAMDQKLVPYLDLIKSVAPVMVRNEFGRIVNIVGNIGREPTAGMFLSGLVNAAVS
                     NAVKYLASQYARHNVTVNCVHPGIIRTQRYDNAVAHMARTGGITRQDAEERLRRAIPMD
                     RPGEADEVAALIGFLASDESSYVTGQQISVDGGHMTCV"
     CDS_motif       complement(17612..17725)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4902_RS33075_0002"
                     /evalue="1.80E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="K4902_RS33075"
                     /protein_end="204"
                     /protein_start="166"
                     /score="1.4"
                     /tool="antismash"
                     /translation="KYLASQYARHNVTVNCVHPGIIRTQRYDNAVAHMARTG"
     aSDomain        complement(17879..18214)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS33075_PKS_KR.1"
                     /evalue="6.40E-07"
                     /label="K4902_RS33075_PKS_KR.1"
                     /locus_tag="K4902_RS33075"
                     /protein_end="115"
                     /protein_start="3"
                     /score="21.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIILGAGRGIGRATALHLSAKGYTTVLCARGSEDLEKVAAEANA
                     GTGDGGRSAYVLPGDVTSPSFREELVGDVERRFGRIDVLINNAPGPPPGHFDDILVDDV
                     RSAMDQKL"
     CDS_motif       complement(18146..18208)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4902_RS33075_0001"
                     /evalue="3.50E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K4902_RS33075"
                     /protein_end="26"
                     /protein_start="5"
                     /score="10.1"
                     /tool="antismash"
                     /translation="IILGAGRGIGRATALHLSAKG"
     gene            complement(18220..18924)
                     /locus_tag="K4902_RS33080"
                     /old_locus_tag="K4902_33080"
     CDS             complement(18220..18924)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.5"
                     /locus_tag="K4902_RS33080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33080"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_073815574.1"
                     /transl_table=11
                     /translation="MTAEVREHPYFPAPGVTLHDDGVRIESYRREDTEVRLLYIAPGAG
                     VRGDESRREAHVGMVIRGEISATVGDVTKLMKPEHDVYVAPPGIELSAVNTSSAETILL
                     EIRRCKAGESYPAPSGYFLEPLESRKFVKMDVTFFLADWIELMVADIPGGGEMPYHKHS
                     HEQIGTCLDGRYEMTVEGSRHELQFGATYFCGSQEGHGAANPNESLARSLNIFIPPRYH
                     RVPQQEAEQESR"
     gene            complement(18905..19537)
                     /locus_tag="K4902_RS33085"
                     /old_locus_tag="K4902_33085"
     CDS             complement(18905..19537)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS33085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_33085"
                     /product="hypothetical protein"
                     /protein_id="WP_079197038.1"
                     /transl_table=11
                     /translation="METVRIPDSEKQALMALIPADATQRVAIGTLGPKGTSSEHIARLM
                     LHSVGDPESCRIVLKDTFEQCMDALVGARIELALVPHAYSHINVFYMHPGLEPVSVFYG
                     STPEYGLAARADFPFHEELLSTETVATHPAPIPMLQHHFDHPVKLATVSSTSQAADHVA
                     SGRYNIALTNEQAVEEYNLKFVYRFSRIPMTWTVFSRRKDLNDRGSA"
     misc_feature    complement(19621..19636)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.26"
                     /tool="antismash"
     gene            20153..21022
                     /locus_tag="K4902_RS33090"
                     /old_locus_tag="K4902_33090"
     CDS             20153..21022
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031520.1"
                     /locus_tag="K4902_RS33090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33090"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_221747305.1"
                     /transl_table=11
                     /translation="MTQDADPGLFGPRSVTWQLHSDPVMWLAGVRALWLQALHPVAVRG
                     VMINSSFREDPWGRLMRTASFVGTLSYETADVAEAAAARVRRIHRLLGVDDPELLLWVH
                     CAETDSYLSVARRSGLPLTDTLADRYVDEHRTSARLIGLDPAAVPGSAAELAAYFDAVR
                     PRLTAGPDARTVEAFLRRPPVKPVLVPAREVIWRRVTALAYDTLPPYAHALYGHPAPPP
                     ATVTRRLVATAGLLRRVPAHLRWRLPPGHIIRAVERLGPEARPDPYAYPAPYPLSEPAS
                     ILEEPEKA"
     gene            21049..23472
                     /locus_tag="K4902_RS33095"
                     /old_locus_tag="K4902_33095"
     CDS             21049..23472
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031519.1"
                     /locus_tag="K4902_RS33095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_33095"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_221747306.1"
                     /sec_met_domain="Pkinase (E-value: 2.6e-50, bitscore:
                     169.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDSRLIQGRYRLHEVIGRGGMGEVWRATDEALGRGVAVKCLKPL
                     GPQQDPQVLTVVRERFRREARVAAALQHRGITVVHDFGEDDGVLFLVMELLEGRNLSQL
                     LAANAQHPLPVQDVVEIADQVADALAYTHGHGIVHRDLKPANIMRLRDGTVKICDFGIA
                     RLGADMGFTSRLTGTGIAMGTPHYMSPEQIGGGEIDHRSDLYSLGCVLYELATGAPPFD
                     LGDSWAILIGHRDTVPRPPRAHRAELPDYFDRIVVDLLAKVPEERPADAGDLRRRIVSG
                     RVSPSLAGTTVGMPVPGGTVVPGPGPGTGPGPIPGPGPIPGPAPIPGPAPIPGPAPVPG
                     PGPVPGPGPIPGQGQGPAPVPGPVPAVGTFPGAPGPAPVPAWVRGITGGPRPADAGAAP
                     RPVAHDPAAAVLTTEWTTARSAPDAPAPVPVAPSAELVAVLAGRYRAGMGLGRLGRWDE
                     AESVHRSVAEHRAAVLGEDHPDTLASRYEVGFALARLDRPADALSVFDRVAAIRARVLG
                     EDHPDTLAARQERAYALGRLGRHPEAYEVYVSVLAARERTVGPDHPDTLRCRHNLAFTL
                     GRLGRLEESYRTAHEVAEARARLLGEDHPDTLVTRHEVAYTLGRLGRGQESLTLYRAVA
                     DARAAALGPDHPDTLAARYETGVCLGRLGQAADALEVCRDLIAARTRAQGAYGTETLRA
                     RHALAVNLGRLGRWPEALAESESVHADRERVLGPEHPDTLLSRRETAVALGRLGRWAEA
                     LEAHRAIAATRTRLLGPVHPDTVAALDDEAHCLERLGRHAEAAALLLRAAAPPS"
ORIGIN
        1 gactcatctg gtcccgcggc tacgcgacgg gcgagttgca gggtcacgtg tacccggacg
       61 taccgcccgc actggagcac tggaggacac agggcacagg ccgcttcgtc tactcctccg
      121 gctccgtggc cgcccagcgg gactggttcg gccacaccgc ccacggcgac ctgcgcccac
      181 tgctcgacgg ctacttcgac ctgacgacgg ccggacccaa ggcggacgcc gactcctacc
      241 gcaccatcgc ggcggagctg ggccacgcgc ccgccgacct gctgttcgtc agcgacgtcg
      301 gcgccgaact cgacgccgcg gccgcggccg gctggcggac ggtggccgtc cgccgccccg
      361 acgacgcacg cgcggccgtg cccggccacg aggccgtcgc ctccctcacc ccactcgttt
      421 cccgacccgg cccgggcagt tccacggcgc cggtcgacac gcacacccag gagggcccga
      481 gcgatgagtg atccgtccgg cacgccgccg caggccgaca tcgcggtcat cggcggcagc
      541 ggcttctacg cactcctgga gtcggtggag cgcgtcgagg tcaccacccc ctacggcgcc
      601 ccgtccgacg cggtgtccgt cggcaccgtg ggcgaccgcc gggtggcctt cctgccccgg
      661 cacggcagcc gccatgaact ccccgcgcac cgcatcaact accgcgccaa catgtgggcc
      721 ctgcgttcgc tgggcgtacg acaggtcctc gccccctgcg ccgtcggctc gctgcgcggt
      781 tccctcggcc ccggaagcgt cgtcctcccg gatcagctcg tcgaccggac cgccggccgg
      841 gtgcagacgt actacgagca cggggccgtc cacgtgtcgt tcgccgaccc gtactgcgcg
      901 tcgggccgcg cggccgtgct caaggccgcg ggagagaccg gcgcggacgt ccacgacggc
      961 ggagtgatgg tcgtcgtcga agggccccgg ttctccaccc gggccgagtc ccggtggtac
     1021 gcctcggcgg gctggtccct gatcaacatg accgggcacc ccgaagccgt actcgcccgt
     1081 gaactcgccc tctgctacac ctccatagcc ctggtcaccg actacgacgc cggcgtggag
     1141 cacggagagg gcgtctcgca ggacgaggtg ttccgcgtgt tcgcggcgaa cgtggaacac
     1201 ctgaagggcc tggtcctgaa gaccgtcggc gtcctggacc gcgagcgggc atgcgcgtgc
     1261 gcgacggcgc tcgacgggat ggacctgccg ttcgagctcc cctgacacgg cgagcggcgc
     1321 gggcgggatc cgcgccgctc ggcgacgtgc gggccgatgc cggtcaccct ggtgaccggc
     1381 atccgtcatt cgacgaccgg gctgcggcgt tccacgagca ggacgtcgcg ccagacgccg
     1441 tgatggcggg ccacccgctc ccgccggccc agcacgcgga accccacgga ctcgtgcagc
     1501 gccaggctcg ccgcgttctc ggggaagatg cccgcctgga tcgtccagat ccccgccctc
     1561 tccgtggaga cgatcaacgc gtccagaagc gcgcgtccca caccggctcc gcgcgccgtg
     1621 ggacagacgt acacggaatg ctcgacgacc cccgcgtagg cggggcgggc cgagacgcgg
     1681 gacaccgccg tccagccgac gaccttccgg tgccggtcga gtgccacgag ccggtgggcc
     1741 ggcagcttgg cggtgtcgaa ggcgctccac ggcggcgcga ccgtctcgaa cgtggcgttt
     1801 ccctcgtcga tgccctgctg gtagatcgcc atgacggcgg gcgcgtggtc gtcggtcatg
     1861 ggggcgagag cgatcgcggt gcggggggga gtggtcatgc tcggctcctt tccggggtgc
     1921 gctcgcggcg gacgcgcacg ggcgggtacg gcgacgctcc cgtggcggcg tcggccgcca
     1981 caggagcgtg gctggggggt gagagaaacg ccgggtcaga gaatcgccag cgagaccagg
     2041 ccgatgccca cgctaccgag gaggcccaca gcgaggtaga acgcgaagac cttcgccttg
     2101 acgacgctct tgacggccac catggccgga atggtcgtga tggcaccgcc gaggaggaag
     2161 gtgacgcccg cggcagccac catgccctgg tccaggaggc cctcgacgac cgggatggcg
     2221 ccgacgccgt tgaggtagag cgggacgctg atgagcccgg cgaccaggac ggagaggacg
     2281 ccgtccgtgc ccaggatgcc cgacacgacg tcggtgggta cgtagcgcac gatcagggct
     2341 tcgaggacga tggcgagcag cagccacttg cccaggatca gcgagtcgct gacgatctcc
     2401 ttgaggatct cgcccgcgcg gaggttcttg atgtcacgcc ggacgagcac acgccacgga
     2461 gtgccgtcgt cgtccgtgtc gttccgtgcc gcggtggagc agcctcccgc cgcgggcgcg
     2521 ggctcctgtg cggagcctcc gcagccaccc tcggaggcgc cgtcaccggc gccgccaccg
     2581 acggtcacgg gctcgggaac ggtcaccttc gcggtggagc acgccgtctc cgggacggtc
     2641 accctggccg tcgagcacgc cgtctcggga acggccaccg tctcctgcga gcaggtcttc
     2701 gcgggcgtct tctcctcggt ggagtcgagc agcggatcgg cgaaccgccc acgccgttcg
     2761 agcgccagga cgatgagacc cgcgccgaag ctcagtacca gggcgccgat gaggcgggcg
     2821 gtggcgatgg ggagcccgag ctgggcggcg gagagcgcgt agatctccgg gtccatggag
     2881 ggggaggcga tccagaacgc catgaccgcc gagagcggga cgcccgctat caggaagcgc
     2941 cggatcagcg ggatcacggt gaaggagcag aaggggctga acgctccgat ggccgtgacg
     3001 acggcgatgc cgaggacgcc cctgcgcccg tgggcgaagc tgcggcgcgc gaccacgtcg
     3061 atcgacagac gctgtacggc gatccccagg acgatggcga ccaggaacca cgggagatag
     3121 tgcagcacct cgaacaggat gaacaggcca agggcccgca attcgtccac gggtgaacct
     3181 ctctgagacg gtgacacatg aggggagcgg cgccgtgaag ggatgtacgg gggacgtggc
     3241 gagccgcgtg ggggaggctc gaacggcatc ccctttatcg aatatcgatg atagacgatt
     3301 aaagagaggc ccggcaatgg ggatcagacc ccgtcggccc gccgaaggtc cccgtcctcg
     3361 cctccgggtc gggcgcgccc agcgtcgcgt acgtgtgccc aggtggcacc ggtgatgatc
     3421 tggaccgggt ggcgcccgca ccgtcgctcg cgccgttggc gcggggcgtg cgcgaggggc
     3481 tggtgggacg atggggccgc tgcggggacc gtctccacgc gggacgaacc ttgccgtcgc
     3541 gggtggtcat cgaataacat cgatggatca tgagcggtac gatgaatgcc cagctgatcg
     3601 accgaagcac ggccgagtcc tatgcaacct ggttcaaggc cctctccgat cccacccgcg
     3661 tgcagatcct caatctcctc gcgctcgcga ccgggccgat gagtgtcgga gagatcgtgg
     3721 accgcatggg cgtcgggcag tcgacggtgt cccaccacct gaagctgctc gccgacgtgc
     3781 gcttcgtcct gcgcgagcgc caggggacgt ccatgctcta ctccatcaac gtcgcctgcg
     3841 tggcctgctt tcccagcgct gccgacgccg tcatgggccg ccccgcggcc tcggcgtgag
     3901 gaccggcccc ttgaccgagt cgacccccca catatccggt ccgcgggctg cggcctgctg
     3961 cccgcccctc gtgacggccg cgctgtccga aggggacgcg gagaccatgg cggcgatgtt
     4021 caaggcgctg gccgaccccg tgcggctccg cctcctgtcc cgagtggcct cacaccccag
     4081 tggtgaggca tgcgtctgcg acatagccga cgtgggcgtc tcccagccca cggtcagcca
     4141 ccatctcaag aagctccggg aagcgggcct tctcacctcc gagcggcgcg gcacctgggt
     4201 gtactaccgc ccggcgcccg gcgtcctggc ctcactgggc gcgtttctcg ccgacacgga
     4261 gaaggccggc caggaagaga tctccatgga ggcccaggtc tcctgacgtc acgacgcgac
     4321 ggcgccgtcg tccccacacg cgggggcggc ggcgccgtcg cgtcgtgacg tcaggccgaa
     4381 gccgcctggg tgagaagcgc tcccatcgcc gcgaggacag tgggctcgac gcggtagtag
     4441 acccaggtgc cgcgtcgttc cgaggagagc agcccggctt ccttcagctt cttcaggtgg
     4501 tgggagaccg tgggctgtga gacgcccacg tcggagatgt cgcagacgca ggcctcgccc
     4561 ccctcgtgcg aggcgacgga ggagaagagc cgcagccgga ccggatcgcc cagcgccttg
     4621 aacatgacgg cggtccgctc ggcctcttcg gcggtcagcg gccgctcgtc gagaggcggg
     4681 cagcagggcg ctatctcggg ctccacgagc ggcagcgact tcacgttcga catgtatcta
     4741 tgttgacaca tgtcgaacca gtccagggtt tggattcgat acttgtctat gttgacgcct
     4801 gtcgaagcaa gtgtcatgct gaaggcgcaa gagatcgaca aacgtcgaat caaaggggaa
     4861 gagccgtgaa cgtcaccgcc accgaccagc tgcccgtcgt ggtcgtcgga gccggacccg
     4921 ccggtctggc cgcggccgcg cacctcgtcg accggggcct ggagcccttg gtcctggagg
     4981 ccggcacccg ggcgggagcc gcggtacggg agtggtccca cgtgcggctc ttctccgcct
     5041 ggggcgaggt caccgacccg gtcgccgaga ggctgctggc cccgaccggc tgggtgaagc
     5101 ccgacccgga cacgtacccg accggcggtg actgggcggc cgcctacctc cagccgctcg
     5161 cggacgtcct cggcgacagg atcaggctcg acgcccgcgt caccggcgta tcccgcaccg
     5221 gtcgcgatcg cgtcgtcgac gccgaccgcg agcagcagcc cttcaccgtg cacgtccggt
     5281 acggcgacgg acgcgaggag cgcgtcctcg cccgtgccgt gatcgacgcc tccggtacgt
     5341 ggaccgcccc gggcccggcc ggcggggacg gcctcccggc cctcggcgag cgcgcggcgg
     5401 ccgaccggat ctcctaccgc gtccccgacc tcaaggaccc cgccgtgcgc gcccggtacg
     5461 cgggcaggcg caccgccgtc atcggctccg gagcctccgc cttcaccgcg ctcgcctcgc
     5521 tcgccgccct cgcgaagtcc cagggcggcg aggccacccg tgcgacctgg atcctgcggc
     5581 gcggcatctc gggcaccacc tacggtgggg gcggcgccga ccagctcccc gcccgtggcg
     5641 ccctcggcct cgcggcgaag gccgcggtcg acgaggggta cgcggacgcc gtcaccggct
     5701 tccgcacgga cgcgatcgag cgcgagggtg agcgcctggt cctggtcgcc gaggacggcc
     5761 ggcggctcga cccggtcgac gaggtcatcg tcctgaccgg gttccgcccc gacctgacct
     5821 tcctcggcga actgcgcctg gggctcgacg agcggctcca ggcccccgtc gggctcgcgc
     5881 cgctcatcga cccgaaccag cactcctgcg gaacggtcta cccgcacggc gtgacggagc
     5941 tgtcgcaccc ggaggagggc ttgtacctgg tcggcatgaa gtcctacggc cgcgctccgt
     6001 ccttcctggc cctcaccggc tacgagcagg tccgctcggt cgtcgccgcc atcgccggcg
     6061 accgcgagtc cgccgagcgc gtcgaactcg tcctccccga gaccggtgtc tgcggcggcg
     6121 caggcctctt cgaccagccc gccgacacca cgaccgacgg cggaggctgc tgcgcgaccc
     6181 cgaccgcgct ccagatcggc ttcggagccc cggcagcctc cggcgcccgc tgaccctgcc
     6241 cgaccaccga cagctggagg acaccatgtc ccgcgtacag ctcgccctgc gcgttcccga
     6301 cctggcggca tccgtcgcct tctacaccaa gctcttcggc agcgaaccgg ccaagctccg
     6361 tgaggggtac gccaacttcg ccatcgccga accgccgctc aagctcgtcc tcgtcgaagg
     6421 caccgagaac gaggacaccc gtctggacca cctcggcgtc gaggtcgaca ccaccgaggc
     6481 ggtccacgcc gccaccgccc gcctgggcga ggccggtctg ccgacgacgg aggagaacga
     6541 caccacctgt tgccacgccc tccaggacaa ggtgtgggtc cacggccccg gccgcgaacc
     6601 gtgggaggtg tacgtggtca aggccgacgc cgacaccctg accaggcaac agggcagcac
     6661 ctgctgcgcc ggcccggccg ccggcgccga cgacgaggtg acagaaccgg tcgccgcggg
     6721 cggttgctgc tgatctcccg atggccgacc tccacacccg cggggccgcg accggaacag
     6781 gggaccggtc gcggccccgc gccgtcctgc ccgccctctg cgtcacccag atcaccggct
     6841 ggggcatcgt ccactacgcc ttcccggtcc tgaacccgca gatcaccgcc gacagcggct
     6901 ggtccaccgg cgccacgacg gcggcgttct cactggcgct cgtcgtctcc gggatcgccg
     6961 gaatccgcgt gggccgcatc atcgaccagc gcggcccgcg catggtcatg acggcaggtt
     7021 ccgcggccgg cgtcgcaggc ctcgccatcg tggccctggc accgaacctg cccgtcttct
     7081 tcgccggttg gaccctcgcg gggctctcca tggccgccac cttctaccag cccgccttcg
     7141 ccgccctcac ccgctggtgg gcccccgacc acgtccgggc cctcacggtc gtcaccctcg
     7201 ccggcggcct cgcctccacc gtcttcgcgc cgctcaccgc cgtcctggcc gaccaccttt
     7261 cctggcgcgg gacctacctg gtgctggccg cgatcctcgc cgtcgtcacc ctcccggccc
     7321 acgctctcgc gctcagggcc ccctggccgc cgacaccacc cgccccggac ggcacggacg
     7381 ccgaccccgg cacggtcgcc cgcagccggc cgttcgtcct gctcgcggtc gcgttcacga
     7441 tctcggcctt cgcgatgtac gccgtcgtcg tcaccctcgt cccgctcctc ctcgaacgcg
     7501 gctacaccac ggcccaggcc gcctgggccc tcggcctcgg cggcgcgggc cagaccctgg
     7561 gccgcactct ccacgccccg ctcgcccgcc gcaccggcac gacggtccgc accacgacgc
     7621 tcctcgcact cggcgccctg accaccgccg ctctcgcggt cacgccgggt ccgtacggcc
     7681 tggtgatcgc ggtgtcgatc gcggccggca cggtccgcgg caacctcacg ctcctccagg
     7741 ccaccgcgat caccgaccgc tggggcgcgc ggcactacgg ccggctctcc ggacttctca
     7801 gcgcccccgc cacgacggcc gcggccgtgg cccccttcgc ggccgccctg ctcgcggtac
     7861 cactgggcgg atacccggag ctgttcggcg ccctcgccgg cctcggcctg gcggctgctc
     7921 tcgtcgccat ggcgagctcc gggcgaaccg ggaggtaggc cgactcgccc cgaacggact
     7981 gacggaactc catggccgaa cggactgaca gagcttcatg ggcgtggcct ccttgaccgg
     8041 tcgggacgcc gcctgcacag tcggatttgc gcaccgggac ggtgccgcat ccctcctccg
     8101 ccgaccggtc cctcgtccat ggggggggcg ggcggccctg acatccagga gcgactggtc
     8161 cgatggtcct cgacctggtg gtgatcggta cggccatcac tctggggcct ctgcacaaca
     8221 gcgccttcat cctgctgctc tcctcgcggc gcggcgtccg caagggtctg gccttcctgt
     8281 tgtcgtggct ggccaacctg gtcacggtgg tcgccgtcgt gctgctgctc accggcggcc
     8341 agcccccggc ccgtcacagc gtgccgtcga ccgccgcgat cgccgcgaaa ctcgccatcg
     8401 gcctggcact ggtggtgtac ggggagtacc ggcggcgccg cccgccccgc ccccacggcc
     8461 cgccacgctg ggccgcccgg atcgacgacg cctccacggt cacggcggcc ggcctggcat
     8521 ggctgctgca gccctggggg ctggtcggcg ccggtgccgc gacggcgctc gacgcgaacc
     8581 tctccaccgc cgccgcctgg ttcgcgctga ccgcctactg cctgctggcc acgctcagcc
     8641 tcatcgtcat ggagatgtac gtggtctggg tgcccgccgt cgcgcacgcc cgcctgaacg
     8701 ccctgcggac gtccctggca cagcaccagg agcaactgat cgtcaccctg gcgctggtcg
     8761 ccggcgtgtg gctgacggcc cggagcatct acgagctggt cacctgaccg ggaggctccc
     8821 gttgccccca agctgcacct ttcgtctcag ccaactgttg ggtatgccgc cgcggtcgcc
     8881 gctcgtccgc cgatcggatg ggtcagccgg tgcggcgcct gaccttcccg cggctgcgga
     8941 cggtgaggag ggcgcccgcg ccgagcagga ctccgcagaa cccgagcacg agcggcagac
     9001 ggctggacgg gccgggactg gccaggtgcg tcatgtcgtt gccgggagcg gcggcactcg
     9061 tgcttccgct cgacggcggt gccgcggcga ccgtcgcgga tgcggtcccg gtgacggtcc
     9121 cggtgacgga cgcggtgacg gacgcggagg gggacgacga ggccggagcc gacgttgtgg
     9181 ccgacaccga tgtcgacgac gaaattctca cgatccgttc gcccctacgc cccgcatctc
     9241 ccagtcctcg cacagcacgc gacgcgagtc cgtgcagcgt gttctgaagc agtcgacagg
     9301 atttcggtga gcgctctcct gccccagtgc ggtggccgtt cccgttgcgc ctgcctcacc
     9361 ccgcgggaag cagccgggac gtaccagggc gagacccggg gggagttcga ccaggagtgg
     9421 gtgcggccgt acctccccgc ccaggacgcc gtgccggacg gtacgacgga aacctgggtg
     9481 ataccgcgcg ttccccggga ggccgaactg ccgcccgagc ccggcggcac cctcccgccc
     9541 gtggtcatga cccaggcgta ccggcgaggg cgcgaagccc cgaagcgacg acgggccgtc
     9601 cacctcaccg ccgccctggc cgccctcgcc ggttccgccg cgatcgcggg agcgtacgcg
     9661 ttctcccagg gctcggaccc caacgacatg gcagggcctc aaccggccag cgggctcgaa
     9721 gtgctcgacg gcgggcagga gccgttggta tcaccccccg ggagccaggc gaacaccgaa
     9781 ctgcagcaac gcctccgtca gctcgggctg tggccccatc cgctacgagg tcacttcaac
     9841 cggcatctgc aggacgcggt gcagcggttc caggcggaac acggcatcag cgacgactct
     9901 cccggggtct acgggccggc cacccgacac cagctggaat ccatgacctc gtgaccacga
     9961 cggcacgtcg ggccaccgcc gagcatccgc ccgtgcggac tcaggcctcc cggtacgcgg
    10021 ccgacgaagc cgtggacgtg agttcgcggc gccactcggg aggcagggcg gccacggcga
    10081 gggaggcgca ggcccgttcc acgagctgtt cgatccgtgc ctcgatccgc gcgtggaccg
    10141 cggtgccgga gaggcgctca cgcagcagtt cgacctcacc tcgctcgacc agcgcgcgga
    10201 tgcgctcgtc ggaccgcatc gccagggcga gcagcagcgt catcttgccg cggccgaagt
    10261 cctggcgcac cggcttgccg ctcaccgccc cgtcaccgaa ggcgtcgatg aggtcgtccc
    10321 gcagctggaa ggcctcgccc agggcctcgc cgtacggctg gaacgccgcg gcgagatctg
    10381 cgcgaccggc caggagcgcg ccgagggtca gcggacggtg caccgtgtac cggcccgact
    10441 tcaccagcgc gatgtgccgt gcgagttcgg catccggtgt cagctcggcc gcggcggtca
    10501 cgtccatcgc ctgaccggcg atcagttcgg acttgaggtc gaaccactcc cgggccaccg
    10561 ccggggacgt accggccatg aggtagtcgg cgtacgccca ggccaggtcg ccggcgagga
    10621 tcgccaccga ctccccgtag cgcctcggct cgccgaacca ctcccggtcc cggtggatct
    10681 ccgcgtgccg ggcgtggacc gtgggccggg tcctgcggcg gtccgcgtcg tccatcacgt
    10741 cgtcgtggat gagcgccgac acgtgcagga gctccagcgc catcgcggcc cggaccggtg
    10801 cctccccggg ctctcccccc gcggcgagat agccgctgag gaggaacctc ggacgcagcc
    10861 gcttgcctcc ggcaccgacc agctcggcca ccgccagagc cggctccgct cctctgccgt
    10921 ccggccgcga ccagcggaac cgctcctgcg agaggaaggc gcgcagaccg ctctccacct
    10981 gtgcgagcag tgcccgcagg tcgtcccgtg cggacgggtc cgggccggcg ggggccgtcc
    11041 tcgtcatggt tccgccttcc ggcgaccgcg cctcgcgcgc ggtcaccggc gacgctcttc
    11101 cacgcgcatg agcgactcct tgggccgcag cgtggagccc gcgaccgggc ggggcggccg
    11161 tcccgtcacg gaccgcatcc gccagcggcc catgagcgag gcgaggatca gagtgatctc
    11221 ggcgtaggcg agcgactcgc cgatgcactt gcgcaccccg gccccgaacg gcagataggc
    11281 gtgccgagga acggttgccg cccgctcggg gagccagcgg tccgggtcga acctgccggg
    11341 gtcggcgaag accgccgggt cgcggtggag ggcgtacggg ctgaagaaca cgtccgcgcc
    11401 ctcgggtatg cggtggccgc cgaggacgac cgaggaggtc gcccgccggg tgaggatcca
    11461 gccggtcggg tacatccgga gcagctcctg gacgacgcgg ccgaggtagg ccagggaggg
    11521 caggtcggcg tagcccaccg gccggccgtc cagcacctcg tcgagctccg cgtgcacccg
    11581 gcgttcgacg tccggccggg cggccagtac ctggaaggcc cagagcagca gggtcgccga
    11641 ggtctccgtg cccgcgacca tcatcgaccg gatctcgtcg tggagctgct cggtggtcat
    11701 gccctcgccg gtctgctcgt cacgcgccag catcagcgtc gacagcaggt cgtcctggtc
    11761 gaggtcgctc gcccggtagt ccgagatgat gccgtcgacc acctcgtaga gccgtcgcag
    11821 ggactccgcc tcgcgccggt tcaccggcag cgggagcctg tggacgaact cgaccgggat
    11881 gaatgcccgc cggcccacgc ccgccaccag ggccggcagg caccgccgta tctcggccgc
    11941 cgcctcggcg gtgagggacg agaacagcgt cctggcgagg atgtccatgg tcgtgtcgtt
    12001 gagcgcacgg cccaggtcga cgacctcgcc gtcacgccag gacccggaga ccaccacggc
    12061 ggcgtcgagc gccgcacggg cgtagacgcc catccggctg tggtggaagg ccggctgcga
    12121 caggcgtcgc tgccgcaggt ggaactcccc gttcgaggcg gcgagtccgt tcccgaggag
    12181 cttcgtggcc tgctcgaaga gagggccgcc cttctcgaac ttgctctgat gagtgatcag
    12241 cagatccttc atcagctccc cggaactcac catgtacgcc gaccgggtgc cgattcggaa
    12301 gagggcgacc ggagcgtggt cgcgcagtct ctccacgaag tcgaggggcc gcagggccag
    12361 ccacggagcg tgcccgagca gagggaggcc gccggcgagg gcgggggaca gggtgtcgta
    12421 cgtggtcaac gggcttctcc gatctgctgc ggtacgaggc cggtgcgggc gaggccggcc
    12481 cggccggcga ccgcgccgct gcgcccggtg ctcgccttca ggtactccgg ccgccgaccc
    12541 gacgcggccc gccgggtgta ccgcgtcgtc gcgagcgacc agtcgtacgt cacccgcagc
    12601 tggcgggtga gcgccgtcag atggcgatac gtggccgccc gctcggccgg atcgcaggac
    12661 aaccggtcgc agagggacgg gatgtcgtcc gcggcgcgct ggaaccggac gacgagccgg
    12721 cccacccggt cacgtatctc ctcgatcacc tcgtcgcggg agcgaccgct ctcctgttcc
    12781 aggacgagca ccagattgtg ggtgtcgccc cgggcctcct cgtgttcgag ggagtggacg
    12841 tcgttgcagt gcgcgaggat gtcgatctgc agggtgctga gccggagcag taccgggtcg
    12901 gtcaggaccc gctccggcac ctcgtagcgg ccggtccgtt cggcggcgtc cagatagacg
    12961 tacatcgcca tggtctccct gcgcagggcc aggtaaccgg ccagatcggg gacggtccgg
    13021 gcccgccggg cgtcggcctc cgccaggaac gaccggagga aacggcgcca gttccgagcg
    13081 gccctggcct gccacgcggg cgacatgggc gcccgcatcc gggcccacag atcggcggtg
    13141 gcaccggcca gggcctcgat gcccgggggg acccgggccg gcccggcgga cccggtcacc
    13201 gacgagagcg cgaggaccgc ggcctcggcg aaccgggggt cgtcgccggc cggaccgtcg
    13261 aagaagtcgt cgcagaccgc ggtccaggtg atgacgtcgg tcatcacgtc gaggtcgggt
    13321 ccgtcggcct cggggcagaa cccggtcgag acgtccgcga gccgcatgtc caggaagtaa
    13381 ccgatcgcgg cctccgtcgg ccggatcagc cggtgctccg tcgcccagtc cacgccccgc
    13441 cggccggcgc gctccacctg ccgggggagc ggtcgcccgg cggcgaaggg cagggagaag
    13501 tccacatcga tcggcatgtc tcagtcctcg acgtcgacga tgacccaatc gctgatctca
    13561 cgccattgac ggaccgactc ctggtggaac gggtgcacga tgtaccgctc gaccgcctcc
    13621 atgtcgtcca tgaccccctc ggcgaggaag tcgtaggcga tctccctggt ggagacgttg
    13681 cgcccgtagc gccaggcgcg gagctcgggc acctcgccgc ccaccttggc ggtggaacgt
    13741 tccgcctcga gggcgcgcgg gtcgttccag tcgatcccgg gcttgaactt gaacagcacg
    13801 acatgacgta tcacggtgat ggatctcctg cggatcgatg agggctgggg ttcaggcggg
    13861 tcggtcggtc gcttccgcgg tcagcgcgag gagctcctgc ggaccggcgc cccggcagag
    13921 tttgagaatg ctcatcgcga cctgggtgcc gtacgggccg aggccgtccc ggtagcgcgc
    13981 gaggacgtcc atctcccggg acagctccgt gcgcgggccg ccggcgttca tacggctctg
    14041 ctggatgcgg gcggatatcc gggcgcgtcg ggcgagcagt tcgatgatgt gcccgtcgag
    14101 accgtcgatc gcgacgcgct cctgatcgat cccggtggtg ctgtggctcg tctcagtcat
    14161 gaggggttcc ttcttccgtg gcgttccaga acgctgacag tcgggcgacg gcctcccgga
    14221 gacggtcctc cggcgcgagc aggctgaccc ggacgtaacc ttcgccgtgc gcgccgaacc
    14281 aacggccggg cgccaccgcg accttggccc gtgtcagcag ctcgtcggcg aacgcgacgg
    14341 agctgccgcc gccgggtatc ggcagccagg cgaagatcga ccggggttcg tcgatccggt
    14401 ggccggcctc ccgcacgccg gccacgaaga tgtccctgcg gcgctcgtag atcgccgtca
    14461 gctcccggac gcagtcctgc gggccggaca gggccgcgac gccggcccgc tggatgaacg
    14521 gcgggagcga gacgtagtag tgctcctgga tgaggttgat cgcggcgacg acgtccgggt
    14581 tgccgacgac ggcaccgatc cgccatcccg ccatgttgaa catcttcgac agggagatga
    14641 actcgacgcc cacgtccttg gcgccttccg tcgccaggaa cgaggccggc acctggccgt
    14701 cgaagcccag ggcgccgtag gcgaagtcgg acgccacgat gacgtcgtgc tcggccgcga
    14761 agcggaccgt gtcctcgtag aactccggcg gcgccgtcac cgaggtgggg ttgttggggt
    14821 agttgaggaa catcagcttg gcccgctcgc acgtcgccgc gtcgagcgcg gtgtagtccg
    14881 gcaggaagcc gttctccctg aggagcggga gggggtgcat atgggcccgg gccaggacca
    14941 cgcccgccca gtagtcgggg aaggccgggt cgggcatcag gcacacgtcg cccgggttga
    15001 ggaagcactg gctgatctcc accagtccgg ccttcgcgcc gaacaggatc gcgacctccg
    15061 tctccgggtc cagcccgacc tggtggttcg cctcgtacca ctgggctatg gcggccttga
    15121 gttcgagcag ccccgagaag gacgggtacc ggtgggtgcc ggggtcgagc acctcgcggc
    15181 gcagggcctc gacgatgtgc ggaggggtgg ggaggtcggg gttgccctgg cagaggttga
    15241 cgacgtcctc acccgccgcg acgagctggt cgatcctgcc cacggtcgtc gcgaaggaac
    15301 tcctgggcag gtcctggagc cgttgcgcga actcagtctt catgtgcagc gaccctcgcc
    15361 tcgtgtgtcg tgtccttgtc cttgcccggg acgccggcac cgtccgggga tccttcgtgg
    15421 cgccgccggt acacccatcc gctcaggccg aacgcgatga gcgtgatccc ggcgcagacc
    15481 cagccgacgg ccgagaaccc gtacgccgtg aacagggggc cgaggagggc cgcaccgagg
    15541 gccacgccga ggttggtcgc gaggctgtag agggccagga tggcgccgcg gtgctggggc
    15601 gagcactcgc tcagcagagt gctgagcagc gtgaccacca gactctgcat cgcgccccac
    15661 aggaagaggc agacgacgag cagcgccgtc caccgggtga cgaacgggat cgccaccagc
    15721 gccgggacca gccccgcgag cagggcgacc agcaccttct ccttgcccag ttcgtcggcc
    15781 cacctgccgg tgaggaagct ggtggcgaac cccagtccgt agaggaggat catgaggccg
    15841 gtcatggagc tccccgagcc gaaccggtac tgcagggcgc tgccgaggaa cgtgtacatg
    15901 ccgtagaagg cgaacatgtt caggaaggtc gccagcacgt acacggtcac cctcggccca
    15961 cggaacgcct gggcggtcga gcgcacccag ccgcctcgcg acggctccgc ggacttctcc
    16021 gcggcggcag ggtcgccctg gtcgcgggcg ggcttcccgc cgccgaccat gagcagcacg
    16081 aagacgacga gggcgccgag gatcgcgagc agcccgaagg tccagcgcca gcccgcccat
    16141 tccccgacga acgaccccag gggcacgccg aggaccagcg agagcgacca gctcgacacg
    16201 aggatgccca tggccctcgc gcggtgccgg tacgggatct ggtcaccgac gaaggcgtac
    16261 gccgtgggga cgaaggcacc cgtggccagg ccggccagca ccctgcccgt gaagaacgtc
    16321 cccggccctg tggcggacgc gcacagaacc gtgccgagga cgaacatcac catccctacc
    16381 accaggctga ggcggcgcga caccctgtcc ccgagcgggg cgaagagcag cgcgccgacc
    16441 gccgtaccga tgccgtagac gctgaccgac agcgccatca gggccaccgt tgcgccgaag
    16501 gaatcggcca tgttcacaag cagcggtgag accaccagct cctcggatcc gacggcgaag
    16561 attcccgcca tcagcgcgag gacggtcagg acgggaaacc caccggggtg ttccgcgtcg
    16621 gtcgatcggt ccgacactcc agccaacctt tctttcgtgc atgtggaacg agacggctag
    16681 atggccgtgt aaccgccgtc tacggtgagc gcgctgcccg tgatgaagga cgacttgtcc
    16741 gacgcgagga aaaggatcgc gttcgcgacg tcctccggtg tgccgaggcg cccgatcggg
    16801 ttcagcttcg ccttctccgc cttgatatca gcgtcgtgtc cgttggacac gtccgtcatc
    16861 ggggtgtcga tgatgctggg gcagacgcag ttcgccctga tgttgtactt ggcgtagtcg
    16921 acggcgagcg atttcgtcag catcatcacc cctcccttgg tcgagttgta cgcggcgatg
    16981 ccgggccagg cgaccagtcc gctcacggag cagacgttga cgatggctcc gctcgtcgcc
    17041 gtgatcatct cgcggagggc gtgcttggag cacaggaaca tgctcttcag gttggtgtcg
    17101 accaacctgt cccactcgtg ttccgacatc tcgtggaacg gagtggttat ctcgattccg
    17161 gcgttgttga ccaggacgtc gagccgtccg aaaccgtcga cggcggcggc tatgaggttc
    17221 ctgcagtccg cctcgaccgt caggtccgtc gtcacgaaga cggcgtcgtg tccgtcgttc
    17281 ctgagcgcgg cgacgacctc ggtcccgccc ttctcgtcga tgtccgcgac gacgaccttc
    17341 gcgccctgcc gtgcgaattc gatcgcggtc tgcctgccga tccccgatgc ggcaccggtg
    17401 acgacgacca ccttgtcctc gaacatgagc aggtctcctt tcacacgcat gtcatgtggc
    17461 cgccgtcgac cgagatctgc tgaccggtga cgtaggacga ttcgtcggac gccagaaagc
    17521 cgatgagggc ggcgacctcg tcggcctctc ccggcctgtc catcgggatc gcccgtcgca
    17581 ggcgctcttc cgcgtcctgt cgggtgatgc cgccggtccg ggccatatgg gcgacggcgt
    17641 tgtcgtagcg ctgggtccgg atgattccgg ggtgcacgca gttcacggtc acgttgtgcc
    17701 gggcgtactg gctcgccagg tacttgacgg cgttcgagac cgccgcgttg accaggccgg
    17761 agaggaacat gccggccgtg ggttccctgc cgatgttgcc gacgatgttg acgatccggc
    17821 cgaattcgtt gcggaccatc acgggggcga cggatttgat caggtccagg tacgggacga
    17881 gtttctggtc catcgcggaa cgcacgtcgt cgaccaggat gtcgtcgaag tgtccgggcg
    17941 gcggtccggg ggcgttgttg atcaggacgt cgatcctgcc gaaacggcgc tcgacgtcgc
    18001 ccaccaactc ctcgcggaag gacggcgagg tgacgtcgcc cggaaggacg tacgcggacc
    18061 gcccgccgtc acccgttccc gcgttcgcct ccgcggcgac cttctccagg tcctcggaac
    18121 cgcgcgcgca caggacggtc gtgtacccct tggcgctcag gtgcagtgcg gtcgccctcc
    18181 cgatgccgcg gccggcgccc aggatgatcg ctacccgggt caccgggact cctgctcggc
    18241 ttcctgctgg gggacccggt ggtaccgcgg cgggatgaag atgttgaggg agcgggccag
    18301 gctctcgttc gggttggcgg ccccgtgccc ctcctggctc ccgcagaagt aggtggcgcc
    18361 gaactgcagc tcgtggcgcg atccctcgac cgtcatctcg taccggccgt cgaggcacgt
    18421 cccgatctgc tcgtgcgagt gcttgtggta cggcatctcg ccgccgccgg gaatgtcggc
    18481 gaccatcagc tcgatccagt cggccaggaa gaacgtgacg tccatcttga cgaacttgcg
    18541 cgactcgagc ggttcgagga agtaaccgct gggcgcgggg taggactcgc ccgccttgca
    18601 gcgcctgatc tcgaggagaa tggtttcggc ggaactcgtg ttcacggccg agagttcgat
    18661 gccgggcggc gcgacgtaca cgtcgtgctc gggcttcatc agcttcgtga cgtctccgac
    18721 cgtcgcggag atctcgcccc ggatgaccat cccgacgtgt gcctcccgcc gggattcgtc
    18781 gcctcgcaca ccggcgccgg gggcgatgta gaggagtcgt acctccgtgt cctcgcgtcg
    18841 gtaggactcg atccggaccc cgtcgtcgtg aagcgtgacg ccgggagcgg ggaagtaggg
    18901 gtgctcacgc acttccgcgg tcattgagat ccttcctcct tgagaagacc gtccaggtca
    18961 tggggatccg tgaaaacctg tagacgaact tcaggttgta ttcctcgacc gcctgctcgt
    19021 tcgtgagagc gatgttgtag cggccgctgg cgacgtgatc cgccgcctgg ctcgtggagc
    19081 tgacggtggc cagcttcacg gggtggtcga agtggtgttg cagcatggga atcggagccg
    19141 ggtgagtggc tacggtctcg gtgctgagca gttcctcgtg gaaggggaag tcggctcgtg
    19201 cggcaagtcc gtattcgggc gtactcccgt agaagacgct caccggttcc agtcccggat
    19261 gcatgtagaa gacgttgata tgggaatagg cgtgagggac cagagccagt tcgatgcgcg
    19321 cgccgacgag cgcgtccatg cactgctcga aggtgtcctt caggacgatt cggcaggatt
    19381 cggggtcgcc gacgctgtgc agcatcagcc gtgcgatgtg ctcgctgctg gtccccttcg
    19441 ggcccagtgt cccgatcgcg acgcgttgtg tggcgtcggc gggaatgagc gccatgagtg
    19501 cctgtttttc actgtcagga attcggactg tctccatgtc tcgacctcct ctgtggcgtc
    19561 cattcgcggg cttcttctct cggcggcgca gatcgaaatg cgtcgccgag gcgcaggatc
    19621 actggtctgc accaatgtcg ggaatcgatg ggtggacggt tccgacggtg atgcttcccg
    19681 ttccggcgat cttgatcagg agtgacccta ggactccctc gtcggggcaa tcaagcgtga
    19741 ccttgaattg ccgtcaagtc gcggctgatt tccatcggag ggggcgatgt gtttcactct
    19801 tgtttcggcc gaattaaacg agccagatgg cgtgatggtg ctggtccttt tgctgcggat
    19861 ggtgtcggct tgggcctgtc tccgagcccg ggcgtgcgcc gggggaacgt gtacggagag
    19921 tcccgacggg tcgtcatcgg ggggccgcgg ccagccgccg gaaccccttc ccggggagcc
    19981 ccccgccgca tggttggcgg gatcatgtca gtcagcggtg ggtgggaacg agccatgtcg
    20041 aggtctacgc gaggggcgca agggactcca gaggcgcagg ggctccggca ccccgcgaac
    20101 ccgggtgccc gcatctgttc gcgccccgag ggccgggctt agcctgagcg ccatgacgca
    20161 ggatgccgac cccgggctct tcgggccccg ctccgtcacc tggcagctgc acagcgaccc
    20221 cgtcatgtgg ctcgcgggcg tccgcgccct gtggctccag gcactgcacc ccgtcgccgt
    20281 gcgcggcgtc atgatcaaca gcagcttccg ggaggacccc tggggccggc tcatgcggac
    20341 cgcgagcttc gtcgggaccc tcagctacga gaccgccgac gtcgccgagg ccgccgccgc
    20401 ccgggtgcgc cggatccacc ggctgctcgg ggtggacgac ccggagctgc tcctctgggt
    20461 gcactgcgcc gagaccgact cctacctctc cgtcgcacgg cgctccggcc tcccgctcac
    20521 cgacaccctg gccgaccgct acgtcgacga acaccgcaca tcggcccgcc tcatcgggct
    20581 cgacccggcc gccgtcccgg gatccgccgc cgaactcgcc gcctacttcg acgccgtacg
    20641 cccccggctc accgccgggc ccgacgcccg caccgtcgag gccttcctcc gcagaccgcc
    20701 cgtgaaaccc gtcctcgtac cggcgcgcga ggtgatctgg cggcgcgtca ccgcgctcgc
    20761 gtacgacact ctgcccccct acgcccacgc gctctacggc caccccgccc caccgccggc
    20821 caccgtcacc cgccgcctgg tcgcgacggc aggactcctc cgccgcgtcc ccgcccacct
    20881 gcgctggcgc ctcccgcccg ggcacatcat ccgcgccgtg gagcggctcg gcccggaggc
    20941 gcgacccgac ccttacgcgt accccgcccc gtacccactg tccgaaccgg cgtccatact
    21001 ggaggagccg gaaaaggcgt aggaaaccga cgggggcggc agcacacgat gggggactcc
    21061 agactgatcc agggccggta ccgcctgcac gaggtcatcg gccgcggggg tatgggcgag
    21121 gtgtggcgcg cgaccgacga ggcgctcggg cgcggggtcg ccgtgaagtg cctcaaaccg
    21181 ctcggaccac agcaggaccc ccaggtcctc accgtggtgc gcgagcggtt ccggcgcgag
    21241 gcccgggtgg ccgccgcgct ccagcaccgt ggcatcacgg tcgtgcacga cttcggtgag
    21301 gacgacggcg tcctcttcct cgtcatggag ctcctggagg ggcgcaacct cagccagctc
    21361 ctcgccgcca acgcccagca tccgctaccc gtgcaggacg tcgtcgagat cgccgaccag
    21421 gtcgccgacg ccctcgccta cacccacggc cacggcatcg tgcaccgcga cctgaagccc
    21481 gcgaacatca tgcggctgcg ggacggcacg gtgaagatct gcgacttcgg gatagcgcgc
    21541 ctcggcgccg acatgggctt cacctcccgc ctcaccggca ccggcatcgc catgggcacg
    21601 ccccactaca tgtccccgga gcagatcggc ggcggcgaga tcgaccaccg cagcgacctc
    21661 tactcactcg ggtgcgtcct gtacgaactg gccaccggcg ccccgccctt cgacctcggc
    21721 gactcctggg cgatcctcat cggacaccgg gacacggtgc cgcgtccgcc gcgcgcgcac
    21781 cgcgccgagc tgcccgacta cttcgaccgg atcgtcgtcg acctgctcgc caaggtgccc
    21841 gaggaacggc cggccgacgc gggcgacctg cgccgccgga tcgtctcggg ccgggtctcg
    21901 ccgtccctcg ccgggaccac ggtcggcatg cccgtccccg gaggcaccgt cgtcccgggc
    21961 ccaggccctg gcaccggccc gggcccgatc cccggcccgg gcccgatccc cggcccggca
    22021 ccgatccccg gcccggcacc gatccccggc ccggcaccgg tccccggccc gggcccggtc
    22081 cccggcccgg gcccgatccc cggccagggg cagggtcccg ccccggtccc cggcccggtc
    22141 cccgcagtcg gcaccttccc cggcgctccc ggcccggccc ccgtgcccgc gtgggtccgg
    22201 gggatcaccg gcggaccccg gcccgccgac gcgggcgccg cgccgcggcc ggtcgcccac
    22261 gaccccgccg ccgccgtgct caccaccgag tggaccaccg cccgttccgc accggacgcg
    22321 cccgcgcccg tgcccgtcgc cccctccgcc gagctggtcg ccgtgctcgc cggccggtac
    22381 cgggccggga tgggactcgg ccgcctcggc cgctgggacg aggccgagtc cgtgcaccgg
    22441 tccgtcgccg agcaccgcgc cgcggtcctc ggggaggacc accccgacac cctcgcgagc
    22501 cgttacgagg tcggcttcgc cctcgcccgg ctcgaccgcc ccgccgacgc gctgagcgtc
    22561 ttcgaccggg tcgccgcgat ccgcgcccgc gtcctcggcg aggaccaccc cgacaccctg
    22621 gcggcccgtc aggagcgggc gtacgcactc gggcgcctcg gacggcaccc cgaggcgtac
    22681 gaggtgtacg tcagcgtcct cgccgcacgc gagcgcaccg tcggccccga ccaccccgac
    22741 accctgcgct gccggcacaa cctggcgttc acgctcggcc gcctcggccg cctggaggag
    22801 tcgtaccgca cggcgcacga ggtcgcggag gcccgcgccc ggctgctcgg cgaggaccac
    22861 cccgacaccc tcgtgacccg gcacgaagtg gcctacaccc tcggacgcct cggccggggc
    22921 caggagtcgc tcaccctgta ccgcgcggtc gccgacgccc gcgccgccgc cctcggcccc
    22981 gaccaccccg acaccctcgc cgcccgctac gagaccggtg tctgcctcgg acggctcggc
    23041 caggccgccg acgccctgga ggtgtgccgg gacctcatcg cggcccgcac ccgcgcccag
    23101 ggcgcctacg ggaccgagac cctgcgcgcc cgccacgccc tcgccgtcaa cctcggccgc
    23161 ctcggccgct ggccggaggc cctcgcggag tccgagagcg tccacgccga ccgggagcgg
    23221 gtgctggggc ccgagcaccc ggacacgctg ctgagccgcc gtgagaccgc cgtcgccctc
    23281 ggccggctgg gccgctgggc ggaggcgctg gaggcgcacc gcgccatcgc cgccacccgc
    23341 acccgcctcc tcggccccgt ccaccccgac accgtcgcgg ccctcgacga cgaggcccac
    23401 tgcctggagc gcctgggccg ccacgccgaa gcggcggccc tcctgctgag agcggccgcc
    23461 ccgccgtcct gatccgccgc ggggccggag cgggcccggg tgccagggct cgcgacg
//
