LOCUS       NZ_JAIHBQ010000001     25431 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6917755
            Orig. end                         :: 6943186
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25431
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25431
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25431
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15431]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15431
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            269..1414
                     /locus_tag="K4902_RS31420"
                     /old_locus_tag="K4902_31420"
     CDS             269..1414
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827487.1"
                     /locus_tag="K4902_RS31420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31420"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_221747788.1"
                     /transl_table=11
                     /translation="MDEALLRSLTPSVLGVLVRRGADFAAAEDAVQDALVEAVRVWPSD
                     PPRDPKGWLVTVAWRKFLDATRADTARRRREERVDAEPAPGPGAATDDALQLYFLCAHP
                     SLTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVTGERFDRTGDVATV
                     LRVLYLVFNEGYSGDVDLAAEAIRLTRRLAAAIDHPEVAGLLALMLLHHARRAARTAPD
                     GSLVPLAEQDRGRWDTGAIAEGVAILQAALARDRLGEFQAQAAIAALHADARTAEETDW
                     VQIVEWFDELVLLTDSPVVRLNRAVAVGEADGPRAGLAALAEVDASVPRHTAVAAYLHE
                     RDGDLTTAARLYAEAARKATHLAERDHLTRQAARLNHRRDR"
     gene            1529..2350
                     /locus_tag="K4902_RS31425"
                     /old_locus_tag="K4902_31425"
     CDS             1529..2350
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (53-174). E-value: 1.2e-15. Score:
                     48.4. Matches aSDomain: nrpspksdomains_K4902_RS31425_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006350475.1"
                     /locus_tag="K4902_RS31425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31425"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_241845676.1"
                     /transl_table=11
                     /translation="MAESVEMRAQVRETYGPADLSSVPVFAGGFINFGYWRSIDLAGPL
                     SVDDRVRSQEDLYRHVLDAAGPLTGRHLLEVGCGLGVGCALAVREYRPEHVTGMDIHPQ
                     QLDRARNANAALLDASPPRLRFVRGAAEGMPFDDAAFDRVHSVEAAQHFDDLAAFARET
                     ARVLRPGGRVVVASFFTPDDDPGRGTRLADLLDSFADGLDIARPVGRLTEAFTRAGLTD
                     ARATSVGPEVWEGWDRWLSDQWAPGTWPRNFLKAYQEGSLDYYVVTANRAV"
     aSDomain        1688..2050
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS31425_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.20E-15"
                     /label="K4902_RS31425_oMT.1"
                     /locus_tag="K4902_RS31425"
                     /protein_end="174"
                     /protein_start="53"
                     /score="48.4"
                     /tool="antismash"
                     /translation="QEDLYRHVLDAAGPLTGRHLLEVGCGLGVGCALAVREYRPEHVTG
                     MDIHPQQLDRARNANAALLDASPPRLRFVRGAAEGMPFDDAAFDRVHSVEAAQHFDDLA
                     AFARETARVLRPGGRVV"
     gene            2653..3021
                     /locus_tag="K4902_RS31430"
                     /old_locus_tag="K4902_31430"
     CDS             2653..3021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575758.1"
                     /locus_tag="K4902_RS31430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31430"
                     /product="hypothetical protein"
                     /protein_id="WP_073816586.1"
                     /transl_table=11
                     /translation="MPTGSQPERTPDGRYIVVDGRRWRATDPDIPPEPAGRLRAHLMAA
                     RRGVAAARRKDDTGAERAARARVHRAKVALGERGDPWWDQSPTERTARWRDGLKALDEA
                     ESADAAEADQPAEADGDG"
     gene            complement(3046..3786)
                     /locus_tag="K4902_RS31435"
                     /old_locus_tag="K4902_31435"
     CDS             complement(3046..3786)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013006091.1"
                     /locus_tag="K4902_RS31435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31435"
                     /product="restriction endonuclease"
                     /protein_id="WP_079197101.1"
                     /transl_table=11
                     /translation="MKATREVRGGATRPRARVWRDLVLAVGLIGICAGGLALFLKTAEV
                     AGDRRSGVPAAVLVAIAALGVLAVGLAVTRHGRVPVRNRGVTRLAGVPEESAPVLDVPD
                     VGAEALDHAAVDADGFEHAVAALCARDGCTAVEVVGGAGDLGADVVAVTMDGRRVVLQC
                     KHYAEDNRVGSQDLQRFGGTCFTIHEADVAVVVTTSSFTAPATEYAATCGIICVDGEAL
                     AAWTDQLAPAPWDALAPDPTTPVA"
     gene            4059..4982
                     /locus_tag="K4902_RS31440"
                     /old_locus_tag="K4902_31440"
     CDS             4059..4982
                     /NRPS_PKS="Domain: PKS_KR (10-180). E-value: 7.4e-16.
                     Score: 50.5. Matches aSDomain:
                     nrpspksdomains_K4902_RS31440_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824254.1"
                     /locus_tag="K4902_RS31440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31440"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_221747126.1"
                     /sec_met_domain="adh_short (E-value: 1.2e-30, bitscore:
                     105.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSWDLQGRTAVVTGAARGLGEGLARRLSARGMRVALLGREAAT
                     LTAVATTLDTESHVVEVDITDDDAMSRAADEVVRHLGAPSVVIANAGVAAGGPFETSAP
                     ATWRRVIEVNLIGSAVTARSFLPGLRATHGYFLQVASTAAFGAAPMMSAYCASKAGAES
                     FARSLRPEVAGLGVAVGVAYLHWTDTDMIRDVDRHTVLRELRAHMPAPARRVYPVDQVA
                     AWIEHGVVRRRASVYAPPWLRLAQAGRPLYPVLVDLMSRRSLPRLMREHPLDQTGLLGH
                     GGRLEERSLGLSGTERGRDGRDGGGP"
     aSDomain        4089..4598
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS31440_PKS_KR.1"
                     /evalue="7.40E-16"
                     /label="K4902_RS31440_PKS_KR.1"
                     /locus_tag="K4902_RS31440"
                     /protein_end="180"
                     /protein_start="10"
                     /score="50.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAARGLGEGLARRLSARGMRVALLGREAATLTAVATTLDT
                     ESHVVEVDITDDDAMSRAADEVVRHLGAPSVVIANAGVAAGGPFETSAPATWRRVIEVN
                     LIGSAVTARSFLPGLRATHGYFLQVASTAAFGAAPMMSAYCASKAGAESFARSLRPEVA
                     GLGVAVG"
     CDS_motif       4095..4181
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4902_RS31440_0001"
                     /evalue="8.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="K4902_RS31440"
                     /protein_end="41"
                     /protein_start="12"
                     /score="12.0"
                     /tool="antismash"
                     /translation="VVTGAARGLGEGLARRLSARGMRVALLGR"
     gene            5102..5680
                     /locus_tag="K4902_RS31445"
                     /old_locus_tag="K4902_31445"
     CDS             5102..5680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017242346.1"
                     /locus_tag="K4902_RS31445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31445"
                     /product="fasciclin domain-containing protein"
                     /protein_id="WP_221747789.1"
                     /transl_table=11
                     /translation="MNTTLTRRRVSAALAGAALTVSLGALALPASAAEGGGTFGAGCAA
                     VPKEGAGSLDDMADDPVATAASKNPALSTLVTAVQKAGLVDTLNNAKDVTVFAPTNDAF
                     AKIPKADLDKVLADKEMLTKILTYHVVDEPVDKADLADGSFKTLQGGTLTTDGSGDAYK
                     VNDSATIVCGDVQTSNATVHIIDTVLMPK"
     gene            complement(5741..7006)
                     /locus_tag="K4902_RS31450"
                     /old_locus_tag="K4902_31450"
     CDS             complement(5741..7006)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330842.1"
                     /locus_tag="K4902_RS31450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31450"
                     /product="cation:proton antiporter"
                     /protein_id="WP_073817210.1"
                     /transl_table=11
                     /translation="MILSDTVYLAMGLGALGAAIVPRLVFKRPLSTPMVFLAAGAAVAA
                     LPLPVPTVDPVRDRVWVEHVTELCVIVSLMGAGLALNRPFGRRAWGGPWRLLGISLPLT
                     IAGTALIAALLLDWPPALALLVAAVLAPTDPVLAAEVRVGEPTDAENDEDEVRFTLTAE
                     AGLNDGLAFPFVLAALALAAAAGDGWSADWIGQWLLVDVLGKVTAGVVVGLVAGRLLGL
                     MFFRARTDALRLSEHMEGFVALGATFLAYGAAELLHGYGFLAVFVTACTIRAAERSHGY
                     HRVLHEFTEQIERLLTVCLLFLLGGFLVAVGLEDLTWQGALLAVLLVLVVRPAAGWLGL
                     VGFAAGPKEKKVTAFFGIRGIGSLFYLAYALGHTEAFAPHARQLWSVVAFTVLLSVVVH
                     GAAATPVIRRLDRLRRSSPAPP"
     misc_feature    7057..7072
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(7180..7845)
                     /locus_tag="K4902_RS31455"
                     /old_locus_tag="K4902_31455"
     CDS             complement(7180..7845)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061111.1"
                     /locus_tag="K4902_RS31455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31455"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_073816599.1"
                     /transl_table=11
                     /translation="MTAELPSTDPSRLPLRERKKLRTRQALIDTALELFTSRGFGGVTL
                     DELCDAVDVSKRTFFRYFASKEDVAMAPTQDLWRTFLDELETREPVGRPLVELLQETLV
                     AALDRMTEEDWAGRVLRSRRLAGETPSMEAHGLQFCHETSRTALDTLHRRLDFDSSDDL
                     RPQLALDLLVAAFHRALDRWTARTSTPTRADLATDMHSAFTALPGSLTLIVTPRVTTG"
     gene            7942..8871
                     /locus_tag="K4902_RS31460"
                     /old_locus_tag="K4902_31460"
     CDS             7942..8871
                     /NRPS_PKS="Domain: PKS_ER (14-171). E-value: 5e-21. Score:
                     67.0. Matches aSDomain:
                     nrpspksdomains_K4902_RS31460_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061112.1"
                     /locus_tag="K4902_RS31460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31460"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_073816602.1"
                     /transl_table=11
                     /translation="MRALLVDRSAPTGLRLGQAPEPEPAPHQALIRVTATSLNHGEVRF
                     GLREAPDGAVLGWDAAGVVERPAADGSGPAAGTPVVTLGIDGAWAELRAVDTDWIGTVP
                     PGADPGAVSTVPVAGASALRALHRAGPLLGRRVLVTGATGGTGRYAVRLARLGGAHVIA
                     STGDPGRHGDSLRADGAHEVVAGPLDVGGPVDGVVELVGGRHLVDAYSRLAQGGTLVAV
                     GHAAHQGENFPLGALFGDQGRHDRSIVTFFLPACTGLAPDLTWLAQRVAAGELDPRISW
                     RGGWEKAADAIDALLQRRLHGKAVLEIG"
     aSDomain        7984..8454
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4902_RS31460_PKS_ER.1"
                     /evalue="5.00E-21"
                     /label="K4902_RS31460_PKS_ER.1"
                     /locus_tag="K4902_RS31460"
                     /protein_end="171"
                     /protein_start="14"
                     /score="67.0"
                     /tool="antismash"
                     /translation="RLGQAPEPEPAPHQALIRVTATSLNHGEVRFGLREAPDGAVLGWD
                     AAGVVERPAADGSGPAAGTPVVTLGIDGAWAELRAVDTDWIGTVPPGADPGAVSTVPVA
                     GASALRALHRAGPLLGRRVLVTGATGGTGRYAVRLARLGGAHVIASTGDPGRH"
     CDS_motif       8341..8403
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4902_RS31460_0001"
                     /evalue="5.50E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="K4902_RS31460"
                     /protein_end="154"
                     /protein_start="133"
                     /score="15.8"
                     /tool="antismash"
                     /translation="GRRVLVTGATGGTGRYAVRLA"
     gene            complement(8994..10004)
                     /locus_tag="K4902_RS31465"
                     /old_locus_tag="K4902_31465"
     CDS             complement(8994..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120220.1"
                     /locus_tag="K4902_RS31465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31465"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_221747127.1"
                     /transl_table=11
                     /translation="MKPEPSARRSRLPLSLRRGAVPWDRQRPTWRDARPGVIAEALKRA
                     QARPSGNWYVVGASAALRGDRPLARTIAGREVVVWRGADGRLLAGPGVCPHLGAPLADS
                     PVRCGTLVCHWHGLALDGAPFGGWDPLPAFDDGVLVWVRLDEVGGEEPLDAPVVPVRPH
                     PARGVTAVYEGTGVCEPEDVVANRLDPWHGAWFHPYSFVDLTVVGSPGEPDADDRFTVD
                     VSFKVAGRLVVPVRAVFTAPEPRTVVMHITEGEGVGSVVETHATPLGPDERGRPRTAVT
                     EAVVAASDRPGFGFVRRAAPLLRPAMRVAAARLWRDDLAYAERRWQLRSTGRFPG"
     gene            complement(10001..11017)
                     /locus_tag="K4902_RS31470"
                     /old_locus_tag="K4902_31470"
     CDS             complement(10001..11017)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670294.1"
                     /locus_tag="K4902_RS31470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31470"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_073816608.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.1e-118,
                     bitscore: 394.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-60,
                     bitscore: 204.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDSAGITDPVLRAAYRRCRELNAAHGKTYFLATRLLPVDR
                     RPAVHALYGFARWADDIVDVPEPGGDDGLRGERLAALQRRLDDGLRQEGGDEPVVLALA
                     DTARRYAIEHGHFRDFMAAMRSDLEVTDYATYADLRAYMHGSAAVIGLQMLPVLGTVVP
                     REEAEPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAGHGVDRELLLRCRDTGRQ
                     DRRVLAALREFEALTRRVYREAEPGLAMLDPLSRPCIRTAYILYGGILDAVARDGYAVL
                     HRRAVVPRRERATVAVDGLARVLAARLRHRNRSAPPGTPARPAQPAAPARPVPEEVA"
     gene            complement(11014..12534)
                     /locus_tag="K4902_RS31475"
                     /old_locus_tag="K4902_31475"
     CDS             complement(11014..12534)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134617.1"
                     /locus_tag="K4902_RS31475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31475"
                     /product="phytoene desaturase"
                     /protein_id="WP_073816612.1"
                     /sec_met_domain="DAO (E-value: 9.6e-17, bitscore: 60.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTLSGRTDHVVVVGAGLAGLSAALHLLGSGRRVTVVERDDLPG
                     GRAGRLELNGYRIDTGPTVLTMPDLADEAFAAVGDSLHKRVDLIPLHPAYRASFADGST
                     LDVHTEGDAMAAEVERFAGAREAAGYRRLRVWLERLYRAQMRRFIDANFDSPLDLLTGD
                     LARLAALGGFGRLDRRIGAFLRDERLQRVFSFQALYAGVPPARALAAYAVIAYMDTVAG
                     VYFPRGGMHALPQAMADAAGDAGAELRFGEAVTRLERSGGRVTAVVTAKDRIRCDAVVL
                     TPDLPVTYRLLGRAPRRPVRLRHSPSAVVLHAGTDRTWPQLAHHTISFGAAWRATFDEL
                     TRQGRLMSDPSLLITRPTASDPGLAPPGRHLHYILAPCPNTDIGPGVAAWGELGPRYRD
                     ELLGELERRGLDGIGSAVEDDSLVTPADWAGQGHAAGTPFSVSHTFLQTGPFRPRNLVR
                     GTENAVLAGCGTTPGVGVPTALVSGKLAAARITGGARRPSARTEGAAR"
     gene            complement(12531..14024)
                     /locus_tag="K4902_RS31480"
                     /old_locus_tag="K4902_31480"
     CDS             complement(12531..14024)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827629.1"
                     /locus_tag="K4902_RS31480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31480"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_221747128.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.9e-49, bitscore:
                     166.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPTQAKDHPAAAPSPLPRLVAPSGSSPRRRRAGRAAAGGAHGAG
                     PPRGAALRQVEPVAVDEDVPAAVGHVLDQVLADRLARAGALDTLFARELAERVARFTQA
                     GGKRTRSQLVWWSMRACGGSDGSTASAALRVGAALELLQTCALVHDDVMDGATLRRGRP
                     ALHADVQGRYGDTAAPARAARFGEAAAILAGDLALAWSDDVVAETPLDRWTATMVRRLW
                     SDMRTEMVAGQFLDLQGQLTGSRSQPRALRAACLKSALYSVERPLALGATLAGADGRTI
                     RALCAAGRRVGMAFQLRDDLDDVFGDPERTGKSRGGDIREGKPTYLVALAVARAEAAGD
                     RPALTVLERTLGDENLSPAGLDEVRDVLVRTGARAAVESKIDRLSTQGLRHFDGALPAT
                     EATARLRGLLAAAAVSRAAAPDGCRNAPSGAGPDDSPEGPRGVGPADSPEGSPGLAPAA
                     SAASRASGVASPAPDDPPARSRPAAALAPAGSGAPEARR"
     gene            14244..15431
                     /locus_tag="K4902_RS31485"
                     /old_locus_tag="K4902_31485"
     CDS             14244..15431
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670291.1"
                     /locus_tag="K4902_RS31485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31485"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_073817212.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 2.8e-100,
                     bitscore: 334.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKADVVIVGAGAAGLSLAHRLNGHVPGARTPSVVLVDAPPGPLR
                     PATRTWCFWEAGPGRFDAAVRAEWSHLRVRPPTGPAIEGDIAPLRYKMIRSDDFEALVA
                     GDLEGSPNVRRVEATVDTVEEIPSGARVLTTRPDGRPDVLEARWVFDSRPLGSLPAART
                     TLLQHFHGWFVRTARPVFDPGTVELMDFRTPQPPDGLSFGYVLPTGPREALVEYTEFSP
                     RLLTASGYEAAVRHYADDVLGLGDLETVATETGVIPMTDAPMPRRIGVSVFRIGAAGGA
                     TRPSTGYAFAGLQRQTRAVAAALRQGRTPVPPNAHSPRARAMDAVLLRALDSGRVDGPA
                     LFSRLFARVPTGRVLRFLDGRTGLFEDLSVGRHTPVGPMLRTVIELPGLPRRPYA"
     gene            15464..16183
                     /locus_tag="K4902_RS31490"
                     /old_locus_tag="K4902_31490"
     CDS             15464..16183
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677064.1"
                     /locus_tag="K4902_RS31490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31490"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_221747129.1"
                     /transl_table=11
                     /translation="MTLLRDEDLSAAFDHASRSYDALVAANPGYHSHLRRSVRRLGLPG
                     RGEGLRVLDLGCGTGASTAAIRSVLPAAAVTAVDASAGMLGRAAAKPWADGVRFVHAPA
                     EHLAEAGVDGPFDAVFAAYLFRNVSDPDAVLRTVRTVLRPGGRLGVHEYSLSGRPADRA
                     VWTTVCRGVVQPAATLLGDGPLYRHLWRSVLDFDTAGRFADRLRAAGFDRVRTLPLPGW
                     QTGITHTFVAERGEDGR"
     gene            16180..17736
                     /locus_tag="K4902_RS31495"
                     /old_locus_tag="K4902_31495"
     CDS             16180..17736
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525638.1"
                     /locus_tag="K4902_RS31495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31495"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_221747130.1"
                     /sec_met_domain="DAO (E-value: 3.5e-10, bitscore: 38.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPAHPLPAARRGRDRRARVLPAHAGARRAYARHSVAVIGAGIA
                     GLAAATALAERGVAVTLYEREPYVGGRVGGWPTTLRDGSTVTMSRGFHAFFRQYYNLRG
                     LLRRTDPALARLRGLPDYPLLHADGMRDSFRHVPRTPPWSALGFVALSPSFGLRDLRAM
                     DPVAALPLLDVRVPDVYDRLDDISAYDFLASVRFPERARHLAFEVFSRSFFADPRQLSA
                     AEMALMFHIYFLGSAEGLLFDVPRSPYPTALWDPLVAYLRGHGAEVRTGSPVAHVAPTR
                     DGGYEIAGDHGERRHDAVVLALDAVGLRSLVARSERLGDPAWRERVEGLRTAPPFLVTR
                     LWLDRPVAPDRPGFLGTSGFGGLDNISVLERWEDEAARWAARTGGSVVELHAYAVDPRA
                     DRATEERRLVEQLRRVYPETRTATVVDVRHEWREDCPLFPVGGHEGRPAVRTSDPGLVV
                     AGDIVRTDLPVALMERAATTGFLAANALLERWGVRGQTLWTVPDRGRDAVLRKAAAWAG
                     R"
     gene            17858..19096
                     /locus_tag="K4902_RS31500"
                     /old_locus_tag="K4902_31500"
     CDS             17858..19096
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982651.1"
                     /locus_tag="K4902_RS31500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31500"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_221747131.1"
                     /sec_met_domain="DAO (E-value: 7.4e-07, bitscore: 27.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAAQDATDVLVVGAGVAGLACARDLSAAGVGVRVVEAGDEVGGR
                     MRSDRVEGFVVDRGFQVFNTSYPQVRRRLPLRDLRLRPFTPGVLIHDPSGRLRFTDPTR
                     RPRTLPDLLPGRLAGPRDLAALGLLSARDMLSPPGLLKRRPETTTRTALADAGVSDALV
                     ERFFRPFLSGVFLEEDLETSARVFHLVWRSMLRGTLCLPTAGVGAVPRALADALPHGAL
                     ALESPVAVLTDEGALTADGRELPARAVVVATGPGPVTALLPGVALPGYRTVTTYYHVAP
                     RSPLGEPTLLVDTRRRFLNTCVLSDVVPSYAPPGHALVATSVLGRDGEGRERQVREALG
                     EAYGTGTDGWDLLTVRTIEDALPAMAPPQPLSRTTRVAPGRYVCGDHRATGSVQGALAS
                     GARAAREVLHDLR"
     gene            19115..19792
                     /locus_tag="K4902_RS31505"
                     /old_locus_tag="K4902_31505"
     CDS             19115..19792
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139765.1"
                     /locus_tag="K4902_RS31505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31505"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_221747132.1"
                     /transl_table=11
                     /translation="MDVKDARVLVPGATGVIGAALAERLHGLGARIAVAGRDPDSLARV
                     AAACGDAPARRLDAYDLDGCARSIPWAVGELGGLDAVVVCVGVAGFGPAEEVGDTVAEH
                     LLTVNALAPVAVLRAALAAVPAGGVLAAVTGVVVDAAPAGMADYAASKAALATWLTSVR
                     RERRRIGPAVVDIRLPHVESGFAERAVCGNPPTLPRGRTVDEAVDRILDALTSGGAGAG
                     HGP"
     gene            19905..20648
                     /locus_tag="K4902_RS31510"
                     /old_locus_tag="K4902_31510"
     CDS             19905..20648
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746941.1"
                     /locus_tag="K4902_RS31510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31510"
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_073816629.1"
                     /transl_table=11
                     /translation="MTAQWRPVRQSRTHELVLESIEQQVLAGELKAGDRLPPERELALA
                     LGVSRSALREALRVLETIGALVANVGRGPDAGARIVRNPDDALGRVLRLHLALGSYGVE
                     DVLEARVVLERSSFEAAARSASEEDLAEAEALLARMREAGPDVVTYNDLDTAFHVLIAR
                     SSGNHLVSTLTSAVRESVRTLILQAEEAAEDRAVTVDRLHAEHVELLRLLRAGEGAAAA
                     DLVERHIRGFHGAVVGEREPGAPAS"
     gene            20802..21569
                     /locus_tag="K4902_RS31515"
                     /old_locus_tag="K4902_31515"
     CDS             20802..21569
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049720.1"
                     /locus_tag="K4902_RS31515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31515"
                     /product="(Fe-S)-binding protein"
                     /protein_id="WP_073816632.1"
                     /transl_table=11
                     /translation="MRIGLFATCLGDTLFPDAVRATALLLTRLGHELVFPPDQTCCGQM
                     HINTGYQREPVPLVRAFAEQFGDRAIDAVVMPSGSCAGSVRHQHETVAARYGDAALRAG
                     VAAVKDKTYELSEFLVDVDGTVDVGAYFPHRVTYHPTCHSLRMLRVEDKPLRLLRAVEG
                     IDLVELPEADTCCGFGGTFAVKNAATSSAMLADKLDHVTSTGAAVCTAGDSSCLMHIGG
                     GLSRIRSGTRTLHLAQILAATRTSPLPLPEAAR"
     gene            21566..23104
                     /locus_tag="K4902_RS31520"
                     /old_locus_tag="K4902_31520"
     CDS             21566..23104
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0006089 - lactate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016910600.1"
                     /locus_tag="K4902_RS31520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31520"
                     /product="lactate utilization protein B"
                     /protein_id="WP_221747133.1"
                     /transl_table=11
                     /translation="MSSTFLGMPAAPPRSPYGEGHLRGERTFPKAAATELGNGQLRSNL
                     HKATHTIRAKRLAVTAEVPDWEELRSAGAAIKTDTMNRLPELLEQLEAKVTEAGGTVHW
                     ARDAAEANAIVTRLVAATGSDEVIKVKSMATQEIGLNEHLESHGVTAHETDLAELIVQL
                     ADDRPSHILVPAIHRNREEIRRIFLAEIPGVDPDLSSVPADLAAAARAYLREKFLTVPV
                     AVSGANFGIAETGTLSVVESEGNGRMCLTLPRTLITVMGIEKVLPRYADLEVFLQLLPR
                     SSTGERMNPYTSLWTGVTPGDGPQEFHLVLLDNGRTAALADAVGRQALNCIRCSACLNV
                     CPVYERVGGHAYGSTYPGPIGAVLTPQLAGMHAAKNDPNSSLPYASTLCGACYDACPVK
                     IDIPSLLVELRHQNTEQTGRSAERLAMRAAAAVMGRPKLFKAAQKAAGLGRIAAGRDRT
                     ISHLPPPLRGWSDSRDTPAPPRRTFRDWYASEEGRRALADAAPRGEDDTPEENR"
     gene            23101..23730
                     /locus_tag="K4902_RS31525"
                     /old_locus_tag="K4902_31525"
     CDS             23101..23730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641381.1"
                     /locus_tag="K4902_RS31525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_31525"
                     /product="LUD domain-containing protein"
                     /protein_id="WP_221747134.1"
                     /transl_table=11
                     /translation="MTARETVLGRVRDALALAPQPPTTVDRTYRRGRSLPDAERLELFT
                     DRLVDYKARVRTCTAGETAATLADVLDGLGARRVGVPAGLDRTWLAGWDGTAEEDRADV
                     PAPRLAALDAVVTSSAVSCAETGTIFLDGSADQGRRALSLVPDVHVCVVDLSSVAVGVP
                     EALARLVPERPTTLISGPSATSDIELERVEGVHGPRTLVVVIRTDA"
     misc_feature    24510..24525
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    complement(24707..24721)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 tcgtcgacgg ccaggcgctc gcccccgagg gcaccttcgt ccgctacgac ggcgagggcc
       61 gcccaccggt caccgacggc cccttcgccg agaccaagga cctcatcgcc ggctggatgg
      121 tgatcgacgt cgacagctac gagcgcgccg tcgaactggc cggggaactg tccgccgcgc
      181 ccggagcggg cggcgagccg atccacgagt ggctcgaact ccgtcccttc ctcaccgccc
      241 cgcccaccgt caccgagtga ccacgccgat ggacgaggcc ctgctccgga gcctcacccc
      301 gagtgtcctc ggggtcctcg tccgccgcgg agccgacttc gcggcggccg aggacgccgt
      361 gcaggacgcg ctggtcgagg cggtccgcgt ctggccgtcc gacccgccgc gggaccctaa
      421 gggctggctg gtcaccgtgg cctggcgcaa gttcctcgac gcgacccgtg cggacaccgc
      481 ccgccgccgc cgcgaggaac gcgtcgacgc cgagccggcg cccggccccg gggcggcgac
      541 ggacgacgca ctccagctct acttcctgtg cgcccacccg tcgctgacgc cgtcgtccgc
      601 ggtcgccctc acgctgcgcg cagtcggcgg gctgaccacc cgccagatcg cccaggccta
      661 cctggtgccc gaggcgacca tggcgcaacg gatcagccgg gccaagcgca ccgtgaccgg
      721 cgaacggttc gaccggaccg gggacgtcgc caccgtgctg cgcgtcctct acctggtctt
      781 caacgagggc tactccggtg acgtcgacct cgccgccgaa gccatccgcc tcacccgccg
      841 gctcgcggcc gcgatcgacc accccgaggt cgcgggcctg ctcgccctca tgctgctcca
      901 ccacgcccgg cgcgccgccc ggaccgcgcc cgacggcagc ctggtgccgc tcgccgagca
      961 ggaccgcgga cggtgggaca ccggggcgat cgccgagggc gtcgcgatcc tgcaggcggc
     1021 cctcgcccgc gaccggctgg gcgagttcca ggcccaggcc gccatcgcgg cgctgcacgc
     1081 cgacgcgcgc accgcggagg agaccgactg ggtgcagatc gtcgagtggt tcgacgaact
     1141 ggtgctcctg accgacagcc cggtcgtccg gctcaaccgc gcggtggccg tcggcgaggc
     1201 cgacgggccg cgcgccggcc tggcggcgct cgcggaggtg gacgcgtcgg tgccccgcca
     1261 cacggcggtg gcggcgtacc tccacgagcg cgacggcgac ctgacgacgg cggcacggct
     1321 gtacgccgag gcggcccgga aggcgaccca cctggccgaa cgcgaccatc tgacgcgcca
     1381 ggcggcgcgg ctcaaccacc gccgggaccg ctgacggcgg tcctggacgt ggcggtctcg
     1441 tcggcggtgt cgaccggtcg gccgccgggc gaggcgccgt cgacacgggt gcacccggga
     1501 cgcacactct tccgtggagg tgacgcacgt ggcggaatcg gtggagatgc gggctcaggt
     1561 ccgcgagacg tacgggccgg ccgacctcag ttcggtcccc gtgttcgccg gagggttcat
     1621 caacttcggt tactggcggt cgatcgatct cgccgggccg ctctcggtcg acgatcgcgt
     1681 ccgcagtcag gaggacctgt accggcacgt gctcgacgcc gcgggcccgc tcaccggccg
     1741 gcatctgctc gaggtcggtt gcgggctcgg cgtcggctgt gcgctggccg tacgcgagta
     1801 ccggccggag cacgtgaccg gcatggacat ccatccgcag cagctggacc gcgccaggaa
     1861 cgccaacgcc gctctgctgg acgcgtcccc gccgcggctc cggttcgtcc ggggcgccgc
     1921 ggagggcatg ccgttcgacg acgccgcgtt cgaccgcgtc cacagcgtcg aggccgccca
     1981 gcacttcgac gacctggccg ccttcgcccg cgagaccgcg cgggtcctgc ggcccggcgg
     2041 gcgggtggtg gtcgcgagct tcttcactcc ggacgacgac ccgggccgcg gcacccggct
     2101 cgcggacctg ctcgactcgt tcgccgacgg cctggacatc gcccgtcccg tcggccgtct
     2161 gaccgaggcg ttcacccggg ccggcctgac ggacgcgcgg gccacctccg tcggcccgga
     2221 ggtgtgggag ggctgggacc gctggctctc ggaccagtgg gcgccgggca cctggccgcg
     2281 caacttcctg aaggcctatc aggagggcag cctcgactac tacgtcgtca cggccaaccg
     2341 tgccgtgtga ccggcatcac gcgccgcggt cgtgatgggt gggacggcca gctgcacccc
     2401 ttccgtccgt ggtcggcacg tccaacgcgc cacggcgagc ggcgccttcg gccgtaccac
     2461 gtgcaggggt gaactccccg cgtgcgaggc cgacgcggtc cccgcggaag ccacctgatc
     2521 cgggcggctc tcccgcgcgc gtacgcccgc ggccggggcg gtacgggccg tcgtcctgcg
     2581 cggccgggct gcgatcgggg ccgggggcgg gcaggatcgg tgtcatgggg gcctgaaggg
     2641 agtgaggggc cgatgccgac ggggtcgcag ccggagcgta cgcccgacgg gcgctacatc
     2701 gtcgtcgacg gccgccggtg gcgtgccacc gaccccgaca tccctccgga gcccgccggg
     2761 cggctgcgcg cccacctgat ggcggcgcgc cgtggcgtgg cggcggcgcg gcggaaggac
     2821 gacacggggg ccgagcgggc ggcacgtgcg cgcgtacaca gggcgaaggt cgctctcggc
     2881 gagcgcgggg acccgtggtg ggaccagagc ccgaccgagc ggacggcccg ctggcgcgac
     2941 gggctgaagg ccctcgacga ggccgagagc gccgatgccg ccgaggcgga ccagcctgcc
     3001 gaggccgacg gcgacgggtg accggcgggc gggggagggg cgggctcagg cgaccggggt
     3061 cgtcggatca ggggcgagcg cgtcccacgg ggccggcgcg agctggtccg tccacgccgc
     3121 cagcgcctca ccgtccacgc agatgatccc gcaggtggcg gcgtactcgg tggcgggcgc
     3181 ggtgaacgag ctggtggtca cgacgacggc cacgtccgcc tcgtggatgg tgaagcaggt
     3241 gccgccgaac ctctgcagat cctgggagcc gacccggttg tcctccgcgt agtgcttgca
     3301 ctggagcacc acccgccggc cgtccatggt caccgcgacc acgtcggcgc ccaggtcgcc
     3361 cgctccgccg accacctcca ccgcggtgca gccgtcccgc gcgcagagcg cggcgaccgc
     3421 gtgctcaaag ccgtcggcgt cgaccgccgc gtgatccaga gcctcggccc cgacatcggg
     3481 gacgtccagg acgggggccg actcctccgg gacaccggcg agacgcgtga ccccgcggtt
     3541 ccggaccggc accctgccgt gcctggtcac cgccagcccg acggcgagga cacccagggc
     3601 ggcgatcgcc acgagaaccg cggccggcac ccccgatcgg cggtcccccg ccacttcggc
     3661 cgtcttgagg aagagggcca gaccgcccgc gcatatccct atgagtccga ccgccagcac
     3721 cagatcgcgc cacacgcgcg cacgcgggcg cgtggcccca cccctgacct cccgggtcgc
     3781 cttcatccgg gccctcccct cgctgctcga cggctcacgc acgccgaggc cccgacccgg
     3841 aggggtgtgg ggcggtgtcg ctcccggtcc gcggtcggtg ccgcggcgtc ccctccgaga
     3901 agtcgatgtt cccgacggac gccgcctatc cgtgaacgcg ccctcgaaac ctgaccggga
     3961 ggagccggcc ggcctccgcc actccgcgcg catccggatc ccgccgtggt gagaatagcc
     4021 aggggcgccc gttctgcccc tttcctcacg gaggcgacat gtcacgctca tgggatctgc
     4081 agggacgcac cgctgtcgtg acgggtgcgg cacggggtct cggcgagggc ctggcccgcc
     4141 ggctctcggc ccgcgggatg cgggtggccc tcctgggccg tgaggccgcc accctgacgg
     4201 cggtggccac gacactcgac acggagagcc acgtcgtcga ggtcgacatc accgacgacg
     4261 acgccatgag ccgggccgcc gacgaggtcg tacggcacct cggcgccccc tcggtcgtca
     4321 tcgccaacgc cggcgtcgcc gcgggaggtc ccttcgagac ctccgccccg gccacctggc
     4381 gccgtgtcat cgaggtcaac ctcatcggca gcgccgtgac cgcgcggtcc ttcctccccg
     4441 gcctgcgggc cacccacggc tacttcctcc aggtcgcctc cacggcggcc ttcggcgccg
     4501 cccccatgat gagcgcctac tgcgcctcca aggcgggcgc cgagtccttc gcccgctccc
     4561 tccgccccga ggtggccggc ctcggcgtcg cggtcggcgt cgcctacctg cactggaccg
     4621 acaccgacat gatccgtgac gtcgaccgcc acacggtgct ccgggagctg cgcgcgcaca
     4681 tgcccgcccc cgcccggcgc gtctacccgg tggaccaggt cgccgcctgg atcgagcacg
     4741 gggtggtacg ccgtcgcgcg tcggtctacg cgccgccgtg gctgcgcctc gcccaggcgg
     4801 gacgcccgct ctatcccgtc ctggtcgacc tgatgtcccg acggtcgctg ccgcggctca
     4861 tgcgggagca cccgctcgac cagacgggcc tcctgggtca cggcgggcgc ctggaggagc
     4921 ggtcgctcgg cctctccggc acggaacggg gccgtgacgg gcgcgacggc ggcgggccgt
     4981 gaagaaatat gccgccgacc ccatccgcgg acccttcggg tgccgaagca ctccttgaga
     5041 ggacaaccga cacacggccg gcggccgctg ggcgtccggc cgatcgaagg agcacctcat
     5101 gatgaacacc acgctgaccc ggcgtcgcgt ctccgccgcc ctggccggcg cggccctcac
     5161 ggtctcgctg ggagccctcg ccctgccggc gtcggccgcc gagggcggcg gcacgttcgg
     5221 cgccggatgc gccgcggtgc cgaaggaggg cgccggctcg ctcgacgaca tggcggacga
     5281 cccggtcgcc acggcggcct cgaagaaccc cgccctgtcc acgctcgtca ccgcggtcca
     5341 gaaggccgga ctggtcgaca ccctcaacaa cgcgaaggac gtcaccgtct tcgcacccac
     5401 gaacgacgcc ttcgccaaga ttccgaaggc cgatctggac aaggtcctcg ccgacaagga
     5461 gatgctcacc aagatcctca cctaccacgt ggtcgacgaa ccggtggaca aggccgacct
     5521 cgcggacgga tcgttcaaga ccctgcaagg cggcacgctg accacggacg ggtccggaga
     5581 cgcgtacaag gtgaacgact ccgccaccat cgtctgcggc gacgtgcaga cctccaacgc
     5641 gaccgtgcac atcatcgaca ccgtcctcat gccgaagtga gggacgctcc aggcccggga
     5701 cccggccacg gccccgcccc gggcccgtca cccgctcccc tcacggaggc gcgggcgagg
     5761 agcggcgcag ccggtcgagg cgccggatga caggagtcgc ggcggcgccg tggacgacca
     5821 cggagagcag cacggtgaag gcgaccaccg accacagctg acgcgcgtgc ggtgcgaagg
     5881 cctcggtgtg gccgagggcg tacgcgaggt agaacagcga gccgatgccg cggatgccga
     5941 agaaggcggt gaccttcttc tccttcggcc ccgccgcgaa gccgaccagg ccgagccacc
     6001 ccgcggccgg tcggacgacg aggaccagca ggacggcgag gagcgctccc tgccaggtga
     6061 ggtcctccag gccgacggcc acgaggaatc cgccgagaag gaagagcagg cacaccgtaa
     6121 gcagccgttc gatctgctcg gtgaactcgt gcagcacgcg gtggtagccg tggctgcgct
     6181 cggccgcccg gatggtgcag gccgtcacga acacggcgag gaagccgtag ccgtgcagga
     6241 gttcggccgc tccgtacgcc aagaacgtgg cccccagggc gacgaacccc tccatgtgct
     6301 ccgacagccg cagcgcgtcc gtccgcgcgc ggaagaacat caggccgagc aggcgtccgg
     6361 ccacgagccc caccaccacc ccggccgtga ccttgcccag gacgtcgacg agcagccact
     6421 gtccgatcca gtccgccgac catccgtcgc cggccgcggc ggcgagcgcg agggcggcca
     6481 ggacgaacgg gaaggcgagt ccgtcgttca gtccggcttc ggcggtgagc gtgaaccgga
     6541 cctcgtcctc gtcgttctcc gcgtccgtgg gctctcccac gcgcacctcg gccgccagga
     6601 cggggtcggt cggtgcgagc accgcggcga cgagcagcgc gagcgcgggc ggccagtcga
     6661 gcaggagggc ggcgatgagc gccgtcccgg cgatggtcag gggcaggctg atgccgagaa
     6721 ggcgccaggg cccgccccac gcacgccggc cgaagggccg gttgagggcg agaccggccc
     6781 ccatcagcga cacgatcacg cacagctcgg tcacgtgctc gacccacacc cggtcgcgca
     6841 ccgggtccac cgtcggcacg ggcagcggca gcgcggccac ggcggcgccg gcggcgagga
     6901 agaccatggg cgtcgagaga ggccgcttga agacgagcct cggaacgatg gccgcgccga
     6961 gcgcgcccag gcccatcgcc aggtagacgg tgtcggagag gatcaccccg cccatcctgt
     7021 ccgaaacggc tccgtccatg cgtgtgccgg ggcggtacgc cgagtgcgga cccgggcttg
     7081 gagggcgggc agacggaccg gcacccgagt gcgctcgggc acgccggctc ctggtgtcgg
     7141 tctacggcga cgcggtcgcg gcgctccgaa gcggctcgct cacccggtgg tgacgcgcgg
     7201 ggtgacgatc agagtgaggc tgccggggag ggcggtgaac gcgctgtgca tgtcggtggc
     7261 caggtcggcg cgggtggggg tggacgtgcg ggccgtccat cggtcgagcg ctcggtggaa
     7321 ggcggcgacc agcaggtcca gggcgagttg cggccgcagg tcgtcggagg agtcgaagtc
     7381 gagccgccgg tgcagggtgt cgagcgccgt gcggctggtc tcgtggcaga actgaagccc
     7441 gtgcgcctcc atggacggcg tctccccggc cagccgccgg ctgcgcagca cacggccggc
     7501 ccagtcctcc tccgtcatcc ggtcgagcgc ggcgaccagg gtctcctgga gcagctccac
     7561 cagggggcgc ccgacgggtt cgcgggtctc cagctcgtcg aggaacgtcc gccacaagtc
     7621 ctgcgtcggc gccatggcca cgtcctcctt gctggcgaag tagcggaaga acgtgcgctt
     7681 cgagacgtcc accgcgtcgc acagctcgtc gagggtcacc ccgccgaagc cgcgcgaggt
     7741 gaacagctcc agggcggtgt cgatcagagc ctgacgggtg cgcagcttct tgcgctcccg
     7801 cagcgggagc cggctggggt cggtcgacgg aagctcagcg gtcatggccg agatcgtacc
     7861 ccgagaggcg agcgcccctt gtgcgctcat gccactcagt ggcataactg gggttcttga
     7921 tcctcaccga agggtgcacc catgcgtgct ctgctcgtcg accgctccgc ccccaccgga
     7981 ctccgcctcg gtcaggcgcc cgaacccgaa ccggcccccc accaggcact gatcagggtg
     8041 acggcgacct ccctcaacca cggcgaagtg cgcttcggcc tgcgcgaggc gcccgacggc
     8101 gccgtcctcg gctgggacgc ggccggcgtg gtggaacggc ccgccgccga cgggtcgggc
     8161 ccggcagccg gcacgcccgt cgtcaccctc ggcatcgacg gagcctgggc cgaactccgc
     8221 gccgtggaca ccgactggat cggcacggtc ccgcccggag ccgatcccgg ggccgtcagc
     8281 accgtccccg tcgcgggggc cagcgccctg cgcgccctgc accgcgcggg tccgctcctc
     8341 ggcaggcgcg tcctcgtcac cggcgccacg ggcgggacag gccggtacgc cgtgcggctc
     8401 gcccggctcg gtggggcgca cgtcatcgcg tccacgggcg accccggccg gcacggcgac
     8461 agcctgcggg ccgacggggc gcacgaggtg gtggcagggc ccctcgacgt cggcgggccg
     8521 gtggacggcg tcgtggagct ggtgggcggc cggcacctcg tcgacgccta cagcaggctc
     8581 gcccagggag gcaccctggt cgcggtcggg cacgccgcgc accagggcga gaacttcccc
     8641 ctcggcgccc tgttcggcga ccagggccgt cacgaccgct cgatcgtcac gttcttcctg
     8701 ccggcctgca cgggcctcgc gcccgacctg acctggctgg cccagcgggt cgccgccggg
     8761 gaactcgacc cccgcatctc atggcgcggc ggctgggaga aggccgccga cgcgatcgac
     8821 gccctgctcc agcggcggct ccacggcaag gcggtcctgg agatcggctg acggacggag
     8881 ccgcacggcc gctctccgct tccttgcgca cccgtacggc cgctccccgc ttcacctccc
     8941 gcccccgcac ggccgacagc cccgcccccg gccgccccgc ccgggaaccg ggatcacccc
     9001 gggaaacggc ccgtcgagcg cagctgccag cgtcgttcgg cgtaggccag gtcgtcgcgc
     9061 cacagccggg ccgccgcgac gcgcatcgcc gggcgcagca gcggggcggc ccggcgtacg
     9121 aacccgaagc cggggcggtc ggacgcggcc accacggcct cggtgaccgc cgtgcgcggg
     9181 cggccccgct cgtccgggcc gagcggcgtc gcatgggtct ccaccacgga gcccacgccc
     9241 tccccctcgg tgatgtgcat gacgacggta cgcggctcgg gcgcggtgaa gacggcccgc
     9301 accggcacca cgagccgccc cgccaccttg aaggagacgt cgacggtgaa ccggtcgtcg
     9361 gcgtcgggct cgccgggcga accgaccacc gtcaggtcca cgaacgagta cgggtggaac
     9421 caggccccgt gccacgggtc cagacgattg gccaccacgt cctcgggttc gcagacgccg
     9481 gtgccctcgt acacggccgt caccccgcgc gcgggatgcg gacggaccgg tacgacgggg
     9541 gcgtccaggg gctcctcccc gcccacctcg tcgagccgca cccagacgag gacaccgtcg
     9601 tcgaaggcgg gcagcggatc ccagcccccg aacggcgccc cgtccagagc gagtccgtgc
     9661 cagtggcaca cgagggtccc gcaccggacc gggctgtccg ccaggggcgc ccccaggtgc
     9721 gggcagacgc ccggcccggc gagcagccgt ccgtcggcgc cgcgccagac caccacctcg
     9781 cggcccgcga tcgtccgggc caggggacgg tcgccgcgca gtgcggccga ggcccccacg
     9841 acgtaccagt tcccggacgg ccgtgcctgc gcgcgcttca gcgcctccgc gatgacgccc
     9901 ggcctggcgt cccgccaggt gggccgctgc cggtcccacg ggacggcacc gcgccgcagc
     9961 gagagcggca gacgggagcg gcgtgcggac ggttcgggct tcacgcgacc tcctcgggga
    10021 ccggccgggc cggagcggcg ggctgtgccg gccgcgccgg cgtacccggc ggcgcggacc
    10081 ggttccggtg gcgcagcctg gccgccagca cccgggccag accgtccacc gcgaccgtcg
    10141 cacgctcccg gcggggcacc acggcgcggc ggtgcagcac cgcgtacccg tcccgggcga
    10201 cggcgtcgag gatgcccccg tacaggatgt aggcggtgcg gatgcacggc cgggacaggg
    10261 gatcgagcat ggcgagtccg ggttccgcct cgcggtagac acggcgggtg agcgcctcga
    10321 actcccgcag cgcggccagg acacgacggt cctggcggcc cgtgtcacgg cacctgagga
    10381 gcagctccct gtcgaccccg tgcccggcca gcaggtcggc gggcaggtac acccgcccgc
    10441 ggtcgaggtc ctcgccgacg tcccggagga agttggtcag ctggaacgcc acaccgaggg
    10501 ccgccgcgtg cggttcggcc tcctcgcgcg gcaccaccgt gccgagcacc ggcagcatct
    10561 gcaggccgat caccgcggcc gagccgtgca tgtaggcccg caggtcggcg taggtggcgt
    10621 agtccgtgac ctccaggtcg gacctcatcg ccgccatgaa gtcccggaag tgaccgtgct
    10681 cgatggcgta gcggcgtgcg gtgtcggcca gggccagcac caccggttcg tcgccgccct
    10741 cctgccgcag cccgtcgtcc agccgtcgct ggagcgccgc gagacgctca ccgcgcaggc
    10801 cgtcgtcacc gcccggttcc ggtacgtcga cgatgtcgtc ggcccaccgg gcgaacccgt
    10861 acagcgcgtg cacggccggc cggcgatcga ccggcagcag gcgggtggcg aggaagtacg
    10921 tcttcccgtg cgccgcgttg agctcgcggc accggcggta ggccgctcgc agcaccgggt
    10981 cggtgatgcc cgcggagtcg agttcgcgtg cggtcatcgt gccgcccctt cggttcgggc
    11041 ggagggacgc cgggcgccac cggtgatccg ggccgccgcc agcttccccg acaccagggc
    11101 ggtcggcacg cccacgccgg gagtggtccc gcagccggcc aggacggcgt tctccgtgcc
    11161 ccgcaccagg ttgcgcggcc ggaacggacc cgtctgcagg aacgtgtggg acaccgagaa
    11221 cggggtgccc gccgcgtgcc cctggcccgc ccagtcggcc ggggtgacga gggaatcgtc
    11281 ctcgacggcc gacccgatgc cgtcgagacc gcgccgctcc agctcgccca ggagctcgtc
    11341 ccggtagcgc gggccgagct cgccccaggc ggcgacgccg gggccgatgt cggtgttggg
    11401 gcagggagcg aggatgtagt gcagatggcg gcccggcggg gcgaggcccg ggtcggacgc
    11461 cgtggggcgg gtgatgagca gggacgggtc gctcatcagc cgcccctgac gggtgagttc
    11521 gtcgaacgtc gcgcgccagg cggcaccgaa cgagatcgtg tgatgggcca gctgcggcca
    11581 ggtgcggtcc gtgcccgcgt gcagcacgac ggcggacggg gagtgccgca gccgcaccgg
    11641 ccggcggggg gcccggccga ggagccggta ggtgacgggc aggtccgggg tgaggacgac
    11701 cgcgtcgcag cggatgcggt ccttcgccgt gacgacggcg gtgacgcgcc cgcccgaccg
    11761 ctccagccgg gtcaccgctt cgccgaaccg cagctcggcg cccgcgtccc cggcggcgtc
    11821 ggccatggcc tgcggcaggg cgtgcatgcc gccgcgcggg aagtacaccc cggcgaccgt
    11881 gtccatgtag gcgatgaccg cgtacgcggc gagcgcacgg gccggcggca cgcccgcgta
    11941 cagggcctgg aaggagaaga cccgctgcag ccgctcgtcc cggaggaagg cgccgatgcg
    12001 ccggtcgagt cggccgaagc cgccgagcgc cgcgaggcgg gcgaggtcac cggtcagcag
    12061 gtccaggggg gagtcgaagt tcgcgtcgat gaagcggcgc atctgggccc ggtagagccg
    12121 ctccagccag acacgcagcc gccggtagcc cgccgcctcg cgggccccgg cgaaccgttc
    12181 cacctccgcc gccatcgcgt cgccctcggt gtgcacgtcc agcgtgctgc cgtccgcgaa
    12241 cgacgcccgg taggccgggt ggagcgggat caggtcgacc cgtttgtgca ggctgtcgcc
    12301 gaccgcggcg aaggcctcgt cggcgaggtc gggcatggtc aggacggtcg ggccggtgtc
    12361 gatccggtag ccgttcagct ccagtcgacc cgcccggccg ccgggcaggt cgtcccgttc
    12421 gacgacggtg acccggcgcc cggaccccag caggtgaagg gccgccgaca gaccggccag
    12481 gccggctccg acgaccacca cgtggtccgt acggccggac agcgtgcgcg tcatcgacgg
    12541 gcctccggag ctccggagcc cgccggagcg agagcggctg ccggtcgcga gcgagccggt
    12601 gggtcgtccg gggcggggga ggcgacgccg gaggcacgag aagcagcgga agcggcggga
    12661 gcgaggcccg gcgaaccctc gggggagtcg gcagggccga cgccccgggg gccctcgggg
    12721 gagtcgtcgg ggccggcgcc cgagggcgcg ttccggcaac cgtccggcgc agccgcccgg
    12781 gacaccgccg ccgcggccag cagtccgcgc agacgcgccg ttgcctccgt ggcgggcaga
    12841 gcgccgtcga agtgccgcag cccctgcgtc gacaggcggt cgatcttcga ctcgaccgcc
    12901 gcccgggcac ccgtacgcac caggacgtcc cgtacctcgt cgagtccggc cggcgacagg
    12961 ttctcgtcgc cgagcgtccg ttcgagcacc gtcagggcgg gccggtcgcc cgcggcctcc
    13021 gcccgcgcca ccgccagggc gaccagatac gtcggcttgc cctcgcggat gtccccaccg
    13081 cggctcttgc cggtgcgctc cgggtcgccg aacacgtcgt cgaggtcgtc gcgcagctgg
    13141 aaggccatgc ccacacggcg tcccgccgcg cacagagccc gtatggtgcg gccgtccgcg
    13201 cccgcaaggg tcgcgcccag cgccagcggc cgctcgaccg agtacaacgc gctcttgagg
    13261 caggcggcgc gcagggcgcg cggctgcgag cgcgacccgg tcagctggcc ctggaggtcg
    13321 aggaactgac cggccaccat ctccgtgcgc atgtcgctcc acagccggcg caccatggtc
    13381 gccgtccacc ggtcgagcgg cgtctcggcc accacgtcgt ccgaccacgc cagcgccagg
    13441 tccccggcca ggatcgcggc cgcctccccg aaacgggcgg cgcgggccgg tgccgcggta
    13501 tcgccgtagc ggccctgcac gtccgcgtgc agggccggac gcccgcgccg cagcgtcgcc
    13561 ccgtccatca cgtcgtcgtg gacgagggcg caggtctgga gcagttcgag cgccgccccg
    13621 acgcgcaggg cggccgaggc cgtggagccg tcggatccgc cgcaggcgcg catcgaccac
    13681 cagacgagct gcgaccgggt gcgcttgccg ccggcctggg tgaagcgggc gacccgctcg
    13741 gccagttcac gcgcgaagag ggtgtccagg gcgccggccc gggcgagccg gtcggcgagc
    13801 acctggtcga ggacgtgccc gacggcggcg ggcacgtcct cgtcgacggc gacgggctcg
    13861 acctgccgga gggcggcgcc gcgcgggggg cccgcgccgt gggccccgcc ggcggccgct
    13921 cggcccgcgc gcctccgccg cggcgaggac cccgacgggg ccaccaggcg ggggaggggc
    13981 gacggcgcgg ccgcggggtg gtccttcgcc tgggtcgggc gcatcccggt tcctctcgtc
    14041 gtggcatcga tcgttcttct ccgcgtcttc cgtcccttcc cgtgatacgg atgcggtgcg
    14101 gatcgggtag ccggaatgcg cgggaatgcc accgtctgga cgcacctgtc cgagtggcgg
    14161 ccgccgaaga ccgcatccgg atcgacgccg aggggggaac ccgtacgggt ggcggacagc
    14221 agaaccggga cggagggagc cgcgtgctga aggcggatgt ggtgatcgtc ggggcgggag
    14281 ccgccggcct ctcccttgcc caccggctga acgggcacgt gcccggcgcc cggacgccgt
    14341 ccgtggtcct cgtcgacgct ccgcccgggc cgctgcggcc ggccacgcgc acctggtgct
    14401 tctgggaggc gggccccggc cggttcgacg ccgccgtccg ggccgagtgg agccacctgc
    14461 gggtgcgacc gccgaccggc ccggcgatcg agggggacat cgcgccgctg cggtacaaga
    14521 tgatccgctc cgacgacttc gaggccctcg tcgccggaga cctcgaaggc agccccaacg
    14581 tccgccgggt ggaggccacc gtggacaccg tggaggagat cccctccggg gcccgcgtgc
    14641 tgacgacccg gcccgacgga cgccccgacg tcctggaggc ccggtgggtg ttcgactcgc
    14701 ggcccctggg cagcctcccg gccgcccgca ccaccctgct ccagcacttc cacggctggt
    14761 tcgtacgcac cgcgcggccc gtcttcgacc ccgggaccgt ggaactgatg gacttccgga
    14821 ccccccagcc ccccgacggg ctctccttcg gctacgtcct gcccaccggc ccgcgcgaag
    14881 ccctcgtcga gtacacggag ttctccccgc gcctcctgac ggcgagcggc tacgaggccg
    14941 cggtacggca ctacgccgac gacgtgctcg gcctcggcga cctggagacc gtggcgaccg
    15001 agaccggggt gatccccatg acggacgccc cgatgccccg ccggatcggc gtctcggtgt
    15061 tccggatcgg tgcggcgggc ggtgcgaccc gcccgtccac cggatacgcc ttcgccggac
    15121 tccagcggca gacccgggcg gtcgccgccg cactccggca gggccgcacg ccggtgccgc
    15181 cgaacgccca ctccccgcgg gcccgcgcca tggacgcggt cctcctgcgc gccctcgaca
    15241 gcgggcgcgt cgacggtccc gccctgttct cccggctgtt cgcccgcgtc cccacgggcc
    15301 gggtgctgcg cttcctcgac ggacgcacgg gcctgttcga ggacctctcc gtcggccgcc
    15361 acaccccggt cggccccatg ctgcgcaccg tgatcgaact gcccggcctg ccccgccgcc
    15421 cctacgcctg atccgtcccg ccccacccga ccctggagac cgcatgaccc tgctgcgcga
    15481 cgaggacctc tccgccgcgt tcgaccacgc gtcccgcagt tacgacgcgt tggtggccgc
    15541 gaaccccggc taccactccc acctgcggcg ctccgtccgc cgcctcggcc tgccgggccg
    15601 gggggagggg ctgcgcgtgc tcgacctcgg ctgcggcacc ggcgcctcga cggccgcgat
    15661 ccggtccgtc ctcccggccg ccgccgtcac cgccgtcgac gcctccgccg gcatgctggg
    15721 gcgggccgcc gccaaaccgt gggcggacgg cgtgcggttc gtccacgccc cggccgagca
    15781 cctggcggag gcgggggtcg acgggccgtt cgacgcggtg ttcgccgcct acctgttccg
    15841 caacgtctcc gaccccgacg ccgtcctccg cacggtccgg accgtcctgc gaccgggcgg
    15901 acggctcggg gtgcacgagt acagcctcag cggacgcccc gccgaccggg cggtctggac
    15961 gacggtgtgc cggggcgtcg tccagcccgc cgcgaccctc ctgggggacg ggccgctcta
    16021 ccgccacctg tggcgcagcg tcctcgactt cgacacggcc ggccggttcg ccgaccggct
    16081 ccgcgcggcc ggcttcgacc gggtccggac cctgccgctg ccgggctggc agacgggcat
    16141 cacccacacc ttcgtggccg agcgcgggga ggacggccga tgaccggccc ggcacacccg
    16201 ctgcccgccg cacgccgcgg ccgggaccgc cgggcccgcg tcctgccggc ccacgcgggg
    16261 gcgcgccgcg cctacgcccg gcactccgtc gccgtgatcg gcgccgggat cgccggactg
    16321 gccgccgcca ccgcgctggc cgagcggggc gtcgcggtga cgctgtacga gcgcgagccc
    16381 tacgtcggcg gcagggtggg cggttggccg accaccctgc gggacggcag caccgtgacg
    16441 atgagccgtg gcttccacgc gttcttccgc cagtactaca acctgcgggg tctgctgcgc
    16501 cgtaccgacc ccgccctggc ccgactccgg ggactgcccg actacccgct gctgcacgcg
    16561 gacgggatgc gcgacagctt ccggcacgtg ccgcgcaccc cgccgtggag cgccctcggc
    16621 ttcgtcgcgc tcagcccctc cttcgggctg cgggacctgc gcgccatgga cccggtcgcg
    16681 gcactgccgc tgctcgacgt ccgcgtaccc gacgtgtacg accgcctcga cgacatcagc
    16741 gcctacgact tcctggcgtc cgtccgcttc cccgaacgcg cccgccacct cgccttcgag
    16801 gtgttctccc ggagcttctt cgccgacccg cggcagctgt cggccgccga gatggcgctg
    16861 atgttccaca tctacttcct cggctccgcc gagggcctgc tgttcgacgt gccccgctcg
    16921 ccctacccga ccgccctgtg ggaccccctc gtcgcctacc tgcgggggca cggcgccgag
    16981 gtgcgcaccg gcagccccgt cgcccacgtc gcacccacca gggacggcgg ttacgagatc
    17041 gccggggacc acggcgagcg ccgccacgac gccgtggtcc tcgccctgga cgccgtcggc
    17101 ctgcgatccc tcgtcgcccg ctcggagcgg ctgggcgacc ccgcctggcg ggagcgcgtc
    17161 gaaggcctgc gtacggcccc gcccttcctg gtcacccggc tgtggctgga ccggcccgtc
    17221 gcccccgacc ggcccggctt cctcggcacc agcggcttcg gcggcctcga caacatcagc
    17281 gtgctggagc gctgggagga cgaggcggcc cggtgggcgg cgcgcaccgg cgggtccgtc
    17341 gtggaactcc acgcctacgc cgtcgacccc cgcgcggacc gcgccaccga ggagcggcgc
    17401 ctcgtcgagc agctccgccg cgtgtacccg gagacccgca ccgccacggt cgtcgacgtc
    17461 cgccacgagt ggcgggagga ctgcccgctg ttccccgtgg gcggccacga gggccgtccc
    17521 gccgtacgca cctccgaccc cggtctggtg gtggccgggg acatcgtgcg caccgacctg
    17581 cccgtcgcgc tgatggagcg ggcggccacg accgggttcc tggccgcgaa cgccctcctc
    17641 gaacggtggg gcgtacgcgg gcagacgctg tggacggtgc cggaccgggg ccgtgacgcc
    17701 gtcctgcgga aggcggccgc gtgggccggg cgctgaccgg gcagccgcgg gcgcgcggac
    17761 ggtgcggacg ggcggcgccg catccggcgc cgggtgacgt gcggaacaca gggaacgagc
    17821 ggtgcgagcc gtgccgacag gtgggagagg tggtcgtgtg tccgcagccc aggacgcgac
    17881 ggacgtgctg gtcgtcgggg ccggtgtcgc cgggctcgcg tgcgcccggg acctgtcggc
    17941 cgccggcgtc ggcgtacggg tggtggaggc cggcgacgag gtcggcggcc ggatgcgctc
    18001 ggaccgggtc gagggcttcg tggtggaccg gggcttccag gtcttcaaca cctcgtaccc
    18061 ccaggtccgg cgccggctgc cgctgaggga cctgagactg cggcccttca cccccggtgt
    18121 gctcatccac gacccctcgg gccgcctccg cttcaccgat cccacccgcc gcccgcgcac
    18181 gctgcccgac ctgctgccgg ggcggctcgc cggaccccgc gacctggccg ccctcggact
    18241 gctgtccgcc cgggacatgc tgtcgccccc cggcctgctc aagcgccgtc cggagaccac
    18301 cacccgcacc gcgctcgcgg acgccggagt ctccgacgcg ctggtcgaga ggttcttccg
    18361 ccccttcctg tcaggggtgt tcctggagga ggacctggag acctccgccc gcgtgttcca
    18421 cctggtgtgg cggagcatgc tgcgcggcac cctgtgcctg cccaccgccg gcgtcggagc
    18481 ggtcccccgg gctctcgccg acgccctgcc gcacggtgcc ctggcgctgg agagccccgt
    18541 ggcggtgctc acggacgagg gcgcgctgac ggccgacggc cgcgaactcc cggctcgcgc
    18601 cgtcgtggtc gccaccggcc ccgggcccgt cacggccctg ctgcccggcg tcgccctgcc
    18661 cggctaccgg accgtgacga cgtactacca cgtcgccccg cgctcgcccc tcggcgagcc
    18721 gacgctgctc gtggacaccc ggcgccgctt cctcaacacc tgtgtcctca gcgacgtcgt
    18781 gccctcctac gccccgcccg gccacgccct cgtcgccacc tcggtcctcg gccgggacgg
    18841 ggagggccgt gagcgtcagg tgcgggaggc gctcggtgag gcgtacggga ccggtaccga
    18901 cggctgggac ctgctgaccg tccgcaccat cgaggacgcg ctccccgcca tggcgccgcc
    18961 ccagccgctc tcgcgcacca cccgggtggc gccgggccgg tacgtgtgcg gcgaccaccg
    19021 cgccaccggt tccgtccagg gcgccctggc gtccggcgcg cgggcggccc gggaggtgct
    19081 gcatgacctg cggtgaccgg acgggagacg gatcgtggac gtgaaggacg cgcgtgtcct
    19141 cgtgcccggc gccaccggtg tcatcggtgc cgccctggcc gagcggctgc acggactcgg
    19201 ggcgcgcatc gcggtggcgg gccgcgaccc ggactccctg gcccgggtcg cggccgcctg
    19261 cggcgacgcg ccggcccgcc gcctcgacgc ctacgacctg gacgggtgcg cccgctcgat
    19321 cccctgggcc gtgggcgaac tcggtggtct ggacgcggtc gtggtctgtg tcggggtcgc
    19381 cggattcggt ccggccgagg aggtcggcga cacggtcgcc gagcatctcc tgacggtcaa
    19441 cgcgctcgct cccgtggccg tcctccgcgc ggccctcgcc gccgtgcccg cgggcggggt
    19501 gctcgccgcg gtgaccggcg tcgtcgtgga cgccgcgccg gccggcatgg cggactacgc
    19561 cgcgtcgaag gccgcgctgg cgacgtggct gacgtcggtc cgccgtgaac gccggcggat
    19621 cggcccggcc gtcgtggaca tccggctgcc ccacgtggag tcgggcttcg cggaacgcgc
    19681 cgtgtgcggc aacccgccga ccctgccgcg cggacgcacc gtcgacgagg ccgtggaccg
    19741 gatcctggac gcgctgacgt ccggcggggc gggggcgggg cacggcccgt gacgttccgg
    19801 cccgccgagc cctcgggcac gccgtggctg tggtcggacc aaagttagga tggcctgacc
    19861 ggggcgcggg tctccgtgcc cgtacaccga caggggaggc atccgtgacg gcccagtggc
    19921 gacccgtgcg gcagtcgcgg acgcacgagc tcgtgctgga gagcatcgag cagcaggtgc
    19981 tcgccggcga actgaaggcg ggcgaccgcc tgccgcccga gcgggagctg gccctggcgc
    20041 tgggcgtgag ccggtccgcc ctgcgtgagg ccctgcgcgt cctggagacc atcggcgcgc
    20101 tggtcgcgaa tgtggggcgc ggtcccgacg cgggcgcgcg catcgtacgc aatcccgacg
    20161 acgcgctcgg ccgggtgctg cggctccacc tcgccctcgg cagctacggc gtcgaggacg
    20221 tgctcgaggc gcgggtcgtc ctggagcggt ccagcttcga ggcggccgcc cggtcggcgt
    20281 cggaggagga cctggccgag gcggaggcgt tgctcgcccg gatgcgggag gcggggccgg
    20341 acgtcgtcac gtacaacgac ctggacacgg ccttccacgt gctgatcgcc cggagctccg
    20401 gcaaccacct cgtctcgacc ctcacctccg ccgtccgtga gtccgtgcgc acgctgatcc
    20461 tgcaggcgga ggaggcggcc gaggaccggg ccgtgaccgt ggaccggctc cacgccgagc
    20521 acgtcgagct gctccgcctc ctccgggccg gcgagggcgc cgcggcggcg gacctggtcg
    20581 agcggcacat ccgcggattc cacggcgcgg tcgtcggcga gcgggagccc ggcgcacccg
    20641 cgagctgacg gtcccgtcgc gccccctctc gcccatcgga accgtccgcg tcggttccgg
    20701 ctcccaggcg ctttaaggtc ggaccacatg gtggtcagta cttggcggga gcgaagcccg
    20761 cgcgtatggt cggaccatac ttcgaccgtg gaggtccccc catgcgcatc ggactcttcg
    20821 ccacctgtct gggagacacc ctcttccccg acgcggtgcg ggcgacggcc ctgctgctca
    20881 cccggctcgg ccacgagctg gtcttcccgc cggaccagac ctgctgcggc cagatgcaca
    20941 tcaacaccgg ctaccagcgc gaaccggtgc ccctggtccg cgccttcgcc gagcagttcg
    21001 gcgaccgggc gatcgacgcc gtcgtcatgc cctccggctc gtgcgccgga agtgtgcgcc
    21061 accagcacga gaccgtcgcc gcccggtacg gcgacgccgc cctgcgcgcc ggcgtcgcgg
    21121 cggtgaagga caagacgtac gagctgtccg agttcctggt cgacgtcgac ggcaccgtgg
    21181 acgtcggcgc gtacttcccg caccgcgtca cgtaccaccc gacctgccac tcgctgcgga
    21241 tgctccgcgt ggaggacaaa ccgctccgcc tgctgcgggc cgtcgagggc atcgacctgg
    21301 tcgaactgcc cgaggcggac acctgctgcg gcttcggcgg caccttcgcc gtcaagaacg
    21361 ccgcgacctc ctcggccatg ctcgccgaca agctcgacca cgtgacgtcc acgggcgccg
    21421 ccgtctgcac cgccggggac tcctcctgcc tgatgcacat cggcggcggc ctgtcccgca
    21481 tccggtccgg gacccgcacg ctccacctcg cccagatcct cgccgccacc cgtacctcgc
    21541 cgctccccct cccggaggcc gcacgatgag cagcacgttc ctcggcatgc ccgccgcccc
    21601 gccccgctcc ccgtacggcg agggccatct gcgcggcgag cggacgttcc cgaaggcggc
    21661 cgcgaccgag ctgggcaacg ggcagctccg ctccaacctc cacaaggcga cgcacaccat
    21721 ccgcgccaag cgcctggccg tcaccgcgga ggtgcccgac tgggaggaac tgcgctccgc
    21781 cggggcggcg atcaagaccg acaccatgaa ccggctgccc gagctgctcg aacagctgga
    21841 ggcgaaggtc accgaggccg gcggcaccgt gcactgggcc cgcgacgcgg cggaggcgaa
    21901 cgcgatcgtc acccggctcg tcgccgccac cggcagcgac gaggtcatca aggtcaagtc
    21961 gatggccacg caggagatcg gcctcaacga gcacctggag agccacggcg tcaccgccca
    22021 cgagaccgac ctcgccgagc tgatcgtgca gctcgccgac gaccgcccct cgcacatcct
    22081 ggtccccgcg atccaccgca accgcgagga gatccgccgg atcttcctcg cggagatccc
    22141 gggcgtcgac ccggatctca gttccgtgcc cgccgacctc gccgccgcgg cccgcgccta
    22201 tctgcgcgag aagttcctga ccgtccccgt cgccgtctcc ggcgccaact tcgggatcgc
    22261 cgagaccggc acgctctccg tcgtcgagtc cgagggcaac ggccggatgt gtctgacact
    22321 gccgcgcacc ctgatcaccg tcatgggcat cgagaaggtc ctgccccgct acgcggacct
    22381 ggaggtcttc ctccagctgc tgccgcgatc ctccaccgga gagcggatga acccctacac
    22441 ctcgctgtgg acgggcgtga caccgggcga cggcccgcag gagttccatc tggtgctgct
    22501 cgacaacgga cgcaccgccg cactcgccga cgccgtcggc cgacaggccc tcaactgcat
    22561 ccgctgctcc gcctgcctga acgtctgccc ggtgtacgag cgggtcggcg gccacgccta
    22621 cggttcgacc taccccggcc cgatcggcgc cgtgctcact ccgcagctcg ccggcatgca
    22681 cgccgcgaag aacgacccca actcctcgct gccctacgcc tccaccctct gcggcgcctg
    22741 ctacgacgcc tgccccgtga agatcgacat cccgtcgctg ctcgtggagc tgcgccacca
    22801 gaacaccgaa cagaccggcc gcagcgccga gcggctcgcc atgagggccg ccgccgccgt
    22861 catgggccgg cccaagctgt tcaaggccgc gcagaaggcc gccggcctcg gccggatcgc
    22921 cgccggccgg gaccgcacga tctcccatct gccgccaccc ctgcggggct ggagcgacag
    22981 ccgcgacacc cccgctccgc cccggcgcac cttccgcgac tggtacgcct ccgaggaagg
    23041 ccggcgcgcc ctcgccgacg ccgccccgcg gggcgaggac gacacccccg aggagaaccg
    23101 atgaccgcac gcgagacggt gctcggccgc gtacgcgacg cgctggcgct cgccccgcag
    23161 ccgccgacga cggtggaccg cacctaccgg aggggccgca gcctcccgga cgccgagcgc
    23221 ctggagctgt tcaccgaccg gctcgtcgac tacaaggcgc gggtgcggac ctgtacggcg
    23281 ggggagaccg cggcgaccct cgcggacgtg ctcgacggac tcggcgcccg gcgggtcggc
    23341 gtgcccgcgg gcctcgaccg gacctggctc gccggctggg acggcaccgc cgaggaggac
    23401 cgcgccgacg tgcccgcacc ccgcctggcc gccctcgacg cggtggtgac gtcctcggcg
    23461 gtgagctgcg ccgagaccgg gacgatcttc ctcgacggct cggccgacca ggggcgccga
    23521 gcgctgtccc tcgtccccga tgtccacgtg tgcgtggtcg acctctcctc cgtcgccgtc
    23581 ggagtccccg aggcgcttgc ccggctggtc cccgaacggc cgacgaccct gatcagcgga
    23641 ccgtccgcga cgtcggacat cgagctggag cgggtggagg gcgtccacgg cccgcgcacg
    23701 ctggtggtgg tcatccgcac ggacgcgtga cccgggccgg acgtcatacc cccgcgacgg
    23761 tcagggggag cggcggggcg gcggctccac gccgagcgcc tgctccgtcc agatcgtctt
    23821 gccgcgtgcc ccgtagcgac agccccagcg gttcgccagc tgggcgatga ggaagaggcc
    23881 ccggccgccc tcctcggtgt tcagggccct gcgcagccgg ggctgggtgt tgctggggtc
    23941 ggagacctcg cagacgagga cgcggtcgcg gatgaggcgc agcacgatgg ggccaccggc
    24001 gtagcggagg gcgttggtga cgagttcgct gacgatcagt tccgtggcga acgccggctc
    24061 gtcgaggccc caggcctcca gccggccgtt gacgtcggca cgggcctcgt gcaccgccgc
    24121 cgggtcggcc gggtactccc acgtcgccat gtcgtgctcg gccacggcgc gggtgcgggc
    24181 caggagaagg gtgacgtcgt cgtcgggata gtcgtgggag ggatgaccgg cgatcagctc
    24241 ggcgccgatc cggtcgagcg gctccccctc ccgcaccagc cgggagagcg aggcgagcag
    24301 gccggcctcg ccgtcgccgg tgtcgtggtc ccggcggacg agcccgtcgg tgtagagcgc
    24361 gaggacactg ccgggcggca gcgtcgtcgt gaacacctcg aaggggttgt caccgacgcc
    24421 cagggtcggt ccggggacca cggcgaggta ctcggcgctg ccgtccggca gcaccacggc
    24481 cgggggcgga tggccggcac tggccatctg gcacacccgc gtcaccggat cgtagagggc
    24541 gaacagacac gaggctccga gggtgtcgga ctcgtcggcc tcggtcatca tgcgctgcac
    24601 caggtcgtcg agacgcatca ggagctcgtc cggcgggaga tccagatcgg ccagggtctg
    24661 cacggcggtg cgcagccggg ccatcgtcgc ggtggcctgc aggccgtggc cgatgacgtc
    24721 cccgacgacg agcgcgatcc gcagcgagga cagcgggaac gcgtcgaacc agtcgccgcc
    24781 gacgctgacg ctgccgcccg ccggcagata ggtgccggcg gtctcggccg cggcgctctc
    24841 ggtggccgac gggggcagca ggctccgctg cagcacgacg gccgtgtggt gctcgcgcgt
    24901 gaactggaag gcgttgtcga tcgccagcgc cgcccggtgg cacaggtcct gcatgagctt
    24961 gatgtcggcc tcgtcgaacg ggtcggggtc gtgcgtgcgg tacacggcgg cgtacccgaa
    25021 gaaccggccc cggtggtaga gcggacagcc gagggcgctg cgcatgccct cgggcatgaa
    25081 acgagcgagg agccgcgggt cgtgccccat gatctcccgg agcaggtcgg cgtccgcgac
    25141 gagcaccccg cggacgacca gcgcggccag ctcgggactc tcggactcga tcgcggtcgg
    25201 ctcgcccacc tgggcgagcc cgcggggcca cacgccgtcg gccgaccgga ccgcgacccg
    25261 ccggggcgcg gacgcctccg ccccggggta gccgagggga ggatcgcggc cctggaggac
    25321 gtcgtcgggg aagtcgacgc aggcgaggtc gccgagcgcg ggcaccagga cggccaccag
    25381 gtcgcgggcg ctgtgcacca cgtcgagcga gccgccgatc tcgaaggcgt t
//
