LOCUS       NZ_JAIHBQ010000001     10423 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2850748
            Orig. end                         :: 2861171
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10423
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="17"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10423
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10423
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5423](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5423
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    1323..1338
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(1614..1629)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            1954..2628
                     /locus_tag="K4902_RS12540"
                     /old_locus_tag="K4902_12540"
     CDS             1954..2628
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035844.1"
                     /locus_tag="K4902_RS12540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12540"
                     /product="hemolysin III family protein"
                     /protein_id="WP_221745413.1"
                     /transl_table=11
                     /translation="MTSAMPSVNEIEQFVKPRLRGWLHAGMFPAVIVAGVVLVALAESP
                     RARVACGIFALTACMLFGVSALYHRGDWGPRGEAVLRRLDHANIFLIIAGTYTPLSLLL
                     LPDSTAEPLMWAIWTAALAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFLPDFLRAGGV
                     AVLVLVVVGGLLYSAGGVIYGIKRPNPSPRWFGFHEVFHSLTLAAFIAHYIGISLVAYR
                     HS"
     gene            complement(2641..3657)
                     /locus_tag="K4902_RS12545"
                     /old_locus_tag="K4902_12545"
     CDS             complement(2641..3657)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035843.1"
                     /locus_tag="K4902_RS12545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12545"
                     /product="glycoside hydrolase family 26 protein"
                     /protein_id="WP_221745415.1"
                     /transl_table=11
                     /translation="MSRFLPRPRAALIVLLAAVLVLLLVPDRIAPGERHTTARPVPEAA
                     PLPGVPSGFFTGSDEAGVRRIAQAQAWLGGGALTVGHTYLPGDRWSNIEGHPALFGPWA
                     RWKEARPGRLFVLNVPLLDRSEAGLPDAEVRAGLRSGAAGAYDRHFRVLGERLVEHGLG
                     DAVLVLGWEMNGTTYSHRCGPDPAAWKTYWRRVVGVLRGVPGQRFRFDFTPSRGRDAVE
                     WPRCYPGDDVVDIIGMDAYDQPEGLAFEDQVAEEYGLEHHVRFAAAHGKPVSYPEWGLF
                     RNGDNPAYVRGMLDWFARHRPVYQTVTDYCPHGVWGCADNPESARVVRNALGAPAGP"
     gene            complement(3659..4303)
                     /locus_tag="K4902_RS12550"
                     /old_locus_tag="K4902_12550"
     CDS             complement(3659..4303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239817.1"
                     /locus_tag="K4902_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12550"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_221745417.1"
                     /transl_table=11
                     /translation="MATVDVQGVPGQRRLARGDGTDGTIGAGRALAWLLMITGAAGVLS
                     GWVITIDKFKLLEDPGFQPGCSLNPVVSCGNIMKSEQAGVFGFPNPMLGLVTYAVVVAL
                     GAGLLAGARYRGWLWLGLNAGMLFGVGFCTWLMYQSLYEINSLCLWCCLAWVATIVMFW
                     YVTAHNVRHGVIPAPAGLRTFLGEFTFALPVLHIGIIGMLILTRWWEFWTS"
     gene            complement(4326..4829)
                     /locus_tag="K4902_RS12555"
                     /old_locus_tag="K4902_12555"
     CDS             complement(4326..4829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889043.1"
                     /locus_tag="K4902_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12555"
                     /product="DUF5949 family protein"
                     /protein_id="WP_073809396.1"
                     /transl_table=11
                     /translation="MTSSNVVSESRSISPLGTLSAVFWTTGPTDEKPAAPYLMVYSLGN
                     GRDGREAGVEAMRAAIEGMGLTVGGPVVDASQESGIDAHLLVEAQQAVLTLPFIKVQCS
                     VPAEWEAAANELGHAYLVCSVRPWPQVAPGEPVSEEQLRSFFAGEDPLAGGAHVVLPVR
                     RLQG"
     misc_feature    4906..4919
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.12"
                     /tool="antismash"
     gene            5001..5423
                     /locus_tag="K4902_RS12560"
                     /old_locus_tag="K4902_12560"
     CDS             5001..5423
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007499741.1"
                     /locus_tag="K4902_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12560"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_221745419.1"
                     /sec_met_domain="melC (E-value: 1.2e-43, bitscore: 147.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTRRLALRSLFTLTAAAFTGGALARIARTPRSGAPAAAAPPDG
                     TFDEMYRGRRIQGRPAPADGIEVLVDDRPLHLMRCADGGYLTPIDHYQTYPTPLAATRA
                     AVDELGSAPLTRFAAAHGVHTGRESAWPTHGRTSVI"
     gene            5390..6256
                     /locus_tag="K4902_RS12565"
                     /old_locus_tag="K4902_12565"
     CDS             5390..6256
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239814.1"
                     /locus_tag="K4902_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12565"
                     /product="tyrosinase family protein"
                     /protein_id="WP_221745420.1"
                     /transl_table=11
                     /translation="MAYTRKNQRDLTSAERRKFVAAVLELKRTGTYDDFVRTHIDYYTA
                     DGDGRLRLAHMAPSFLPWHRKFLLEFERALRRVDPTVTVPYWDWTRDNTPAASLWNDDF
                     MGGNGRRGDLQVMTGPFAHSGGRWTITHGMTEGAFLTRDLGHPRAPITLPTGADLDVVM
                     RETVYDVAPWNSTSTSGFRNRLEGWAPGRGNERFRVHNRVHRWVGGLMLGGASVNDPVF
                     WLHHSFVDLIWSRWQQRNPRAGYVPAQPPPPGDAQHGRIAARNERMGPWGVTPAQMLDH
                     SAVYRYA"
     gene            complement(6338..6619)
                     /locus_tag="K4902_RS12570"
                     /old_locus_tag="K4902_12570"
     CDS             complement(6338..6619)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007818707.1"
                     /locus_tag="K4902_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12570"
                     /product="chaplin"
                     /protein_id="WP_073809408.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVLAGTGAVALSGAGLAVADSGAEAVAAHSPGVASGN
                     VVQVPVHVPLNLCGNTVTVIGLINPAFGNSCANVDGHDHGDRDGGYGG"
     misc_feature    complement(6829..6841)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.57"
                     /tool="antismash"
     gene            complement(6912..7388)
                     /locus_tag="K4902_RS12575"
                     /old_locus_tag="K4902_12575"
     CDS             complement(6912..7388)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239813.1"
                     /locus_tag="K4902_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12575"
                     /product="hypothetical protein"
                     /protein_id="WP_079196785.1"
                     /transl_table=11
                     /translation="MTALASAAMAAPASAAEAPVVVPLQGLEPVIPMDAPTVATGVPLP
                     VPGTPTVFHEGHSQALPDIGLPRVPVSSTLPNTVLAAPLPEAVEGSRPGTALLTTPSSP
                     VEAAAPGATVGNPVGLPRGDRFGLPDLTMPGAGVLTPAVNGVLAPQLGLAQPTA"
     gene            complement(7591..8673)
                     /locus_tag="K4902_RS12580"
                     /old_locus_tag="K4902_12580"
     CDS             complement(7591..8673)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_12580"
                     /product="hypothetical protein"
                     /protein_id="WP_221745423.1"
                     /transl_table=11
                     /translation="MRSIITRKLLTAAAATGVLSLTGGFAVAANSTEDAPGPGAGHHRQ
                     VPLSVSLCGDSVQLVDIAARAVRDHCAQAVDDPDGYGDGPDGETPDHPSENPAPPGHPT
                     GPGHPTHPGEPTKPGEPTGPGHPTNPGEPTKPGEPTGPGHPTHPGEPTKPGEPTGPGYP
                     THPGEPTKPGEPTGPGHPTNPGEPTKPGEPTKPGEPTKPGEPTGPGHPTHPGEPTKPGE
                     PTKPGEPTGPGHPTNPGEPTKPGEPTKPGHPTHPGEPTKPPTASPTPPGQHGEPGEPGE
                     STKPPTHPGESTKPPTHPGESTKPPGGPSQSGSGGPGVPQLPDTGRDTAVLTGAAAVSA
                     ALILGGAVVRFRVGRSGRRH"
     misc_feature    complement(8659..8674)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.62"
                     /tool="antismash"
     misc_feature    8760..8775
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            complement(8953..9219)
                     /locus_tag="K4902_RS12585"
                     /old_locus_tag="K4902_12585"
     CDS             complement(8953..9219)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035834.1"
                     /locus_tag="K4902_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_12585"
                     /product="hypothetical protein"
                     /protein_id="WP_073809419.1"
                     /transl_table=11
                     /translation="MKPTKVAAMVAGSVMALGAAAPAMAMGPAEVPTSLDGGLDVISSE
                     GLQTDALSSTTDGSPVQAVGEVTGKLNETTKKVPLLGGLPLAG"
     gene            complement(9485..10108)
                     /locus_tag="K4902_RS12590"
                     /old_locus_tag="K4902_12590"
     CDS             complement(9485..10108)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_12590"
                     /product="hypothetical protein"
                     /protein_id="WP_221745425.1"
                     /transl_table=11
                     /translation="MRPQAPLRLTVLAASAALTLGLAGPAAADVHQPPHASTVAAQAPI
                     GRTAALPAGLGDLGKAVSAAVAELIASIKADGRLTTAASEAFDAKIAQAVEAAKADAMA
                     PLPTTAVPDLPVPDTPAVAPPKAEAPAAATVVARPVAAEAVPADLLGDAGATVQKAVAD
                     LVDLIVSTLLGGLTAIDLPALPGLPALPTPPALPTLPTLPSPSR"
ORIGIN
        1 aggtgttcag gtggtcgggg acgagggcgg cctcctcgcg ccacacgtca cggtcgacct
       61 tgaggaggaa ctccaggtcc tcggccggca ggtccaggcc gtcggtgtcg aaggactccg
      121 gggtcggcag gatgccgatc ggggtctcga cgccctcggc cttgccctcc aggcgctcca
      181 cgatccactt caggacgcgg ctgttctcgc cgaagccggg ccagacgaac ttcccggcgt
      241 cgttcttgcg gaaccagttc acgtagtaga tcttcggcag cttggcggcg tcggcgttcg
      301 ccccgacctt gacccagtgg gccatgtagt cgcccatgtt gtagccgcag aacggcagca
      361 tggcgaaggg gtcgcggcgc agctcgccga ccttgccctc ggcggcggcg gtcttctcgg
      421 aggcgacgtt cgcgccgagg aacacgccgt ggttccagtc gaaggactcg gtgaccagcg
      481 gcacggcgga ggcgcggcgg ccgccgaaga ggatcgcgga gatcgggacg cccttggtgt
      541 cctcccactc cggggcgatc gtcgggcact ggccggccgg gacggtgaag cgggcgttcg
      601 ggtgggcggc cggggtctcg gactccggcg tccagtcgtt gcccttccag tccgtgaggt
      661 gggccggggc cttctcggtc atgccctccc accagacgtc gccgtcgtcg gtgagcgcga
      721 cgttggtgaa gacggagttg ccccagaggg tcttcatggc gttggcgttg gtgtgctcgc
      781 cggtgccggg cgcgacgccg aagaagccgg cctcggggtt gatcgcgtag aggcggccgt
      841 cctcgccgaa gcgcatccag gcgatgtcgt cgccgatggt ctcgacggtc cagccggaga
      901 tcgtgggctc cagcatggcc aggttcgtct tgccgcaggc ggacgggaac gcggcggcga
      961 cgtacttcgc ctcgccctgc ggcggggtca gcttcaggat gagcatgtgc tcggcgagcc
     1021 agccctcgtc acgcgccatg acggaggcga tacggagcgc gtagcacttc ttgccgagca
     1081 gggcgttgcc gccgtagccc gagccgtacg accagatctc gcggctctcg gggaagtgcg
     1141 agatgtactt ggtggagttg cacggccacg gaacgtcctc ctggccctcc tccagggggg
     1201 cgccgagggt gtggacggcc ttgacgaaga agccgtcggt gccgagctcg tcgaggacgg
     1261 cctggcccat gcgggtcatg gtgcgcatgg agaccgcgac gtacgcggag tcggtgatct
     1321 cgacgccgat ggcggagagc ggggagccga ccgggcccat gcagaagggt acgacgtaca
     1381 tggtgcggcc gcgcatggag ccgcggaaga tgcccttctc ccccgcgaag agctccttca
     1441 tctcggccgg ggccttccag tggttggtcg ggcccgcgtc ctcctccttc tcggagcaga
     1501 tgaaggtccg gtcctcgacg cgcgcgacgt cggtcgggtc ggaggcggcg tagtacgagt
     1561 tcgggcgcag ggtcgggtcg agcttcgtga aggtgccctt ggcgacgagc tcctcgcaca
     1621 ggcgctcgta ctcggcctcg gagccgtcgc accagacgat gctgtccggc tgggtgatct
     1681 cggcgatctc gttcacccag gagacgagct cctggtgctg ggtcggaagg gtctggggag
     1741 ccgcgttgtc gcgcgccacg attgctcctt gtagaggggt tttttggtgt gtgccccgtg
     1801 ggggccgcga cccggatgct tcgtagctgc tcatccggtg ccgaccgcac tcatttgatc
     1861 atccgatgga actgcccata tgtccagggg gccgcacacg tgagcatcgc cactcgtatc
     1921 cggggcctac ggaggcgtag gtagcatgcg gacatgactt ccgccatgcc gtcggtgaac
     1981 gagatcgagc agttcgtgaa gcccaggctc aggggctggc tgcatgccgg gatgttcccc
     2041 gcggtgatcg tggcgggggt cgtcctggtc gcgctcgccg agtccccccg ggcccgcgtc
     2101 gcctgcggga tcttcgccct caccgcctgc atgctcttcg gcgtcagcgc gctctaccac
     2161 cgcggcgact ggggcccgcg cggcgaggcc gtcctacggc gcctcgacca cgccaacatc
     2221 ttcctgatca tcgcgggcac ctacaccccg ctcagcctgc tcctgctccc ggactccacg
     2281 gccgagccgc tcatgtgggc gatctggacg gcggccctcg cgggcatcgc cttccgggtc
     2341 ttctgggtcg gcgccccccg ctggctgtac acgccctgct acatcgccat gggctgggcc
     2401 gccgtcttct tcctgcccga cttcctgcgg gccggcggcg tcgccgtcct cgtcctcgtc
     2461 gtcgtcggcg ggctgctcta cagcgcgggc ggcgtcatct acggcatcaa gcgccccaac
     2521 ccgtcaccgc gctggttcgg cttccacgag gtcttccact cgctgaccct ggccgccttc
     2581 atcgcccact acatcggcat ctcgctggtg gcctaccggc actcctgacg ggccccgccg
     2641 tcatggcccg gccggcgccc cgagcgcgtt cctgacgacc cgcgccgact cggggttgtc
     2701 ggcgcacccc cagacgccgt gcgggcagta gtcggtgacc gtctggtaga cgggacggtg
     2761 ccgcgcgaac cagtccagca tcccgcgcac gtacgccggg ttgtccccgt tcctgaagag
     2821 cccccactcc gggtacgaga ccggcttgcc gtgcgccgcc gcgaaccgga cgtggtgttc
     2881 gagcccgtac tcctcggcga cctggtcctc gaacgcgagc ccctcgggct ggtcgtaggc
     2941 gtccatgccg atgatgtcga cgacgtcgtc cccggggtag cagcgcggcc actccacggc
     3001 gtcccgaccc cggctcgggg tgaagtcgaa gcggaaccgc tgccccggca ccccccgcaa
     3061 caccccgacg accctgcgcc agtacgtctt ccaggccgcc gggtccgggc cgcagcggtg
     3121 gctgtacgtg gtgccgttca tctcccagcc gagcaccagg accgcgtccc cgaggccgtg
     3181 ctccacgagc cgctccccga gcacccggaa gtgacggtcg tacgcgccgg ccgcgccgct
     3241 ccgcagcccc gcccgcacct ccgcgtccgg caggcccgcc tcgctccggt cgagcagcgg
     3301 cacgttcagc acgaagagac gccccggccg cgcctccttc caccgggccc agggcccgaa
     3361 gagcgccggg tgcccctcga tgttggacca gcggtcgccc ggcagatacg tgtgcccgac
     3421 ggtcagcgcc ccgccgccca gccaggcctg cgcctgggcg atcctgcgga cccccgcctc
     3481 gtcggagccg gtgaagaacc ccgacggcac cccgggcagg ggcgccgcct cgggcacggg
     3541 ccgggccgtg gtgtgccgct cgcccggcgc gatccggtcg ggcacgagca gaagcacgag
     3601 aacggccgcg agcagcacga tcagtgccgc ccgcggccgg gggaggaaac ggctcacgtc
     3661 aactcgtcca gaattcccac caccgggtca ggatcagcat cccgatgatc ccgatgtgca
     3721 ggacgggcag ggcgaaggtg aactcgccga ggaacgtccg cagccccgcc ggggcgggga
     3781 tcaccccgtg gcggacgttg tgcgcggtga cgtaccagaa catgacgatg gtggcgaccc
     3841 aggccaggca gcaccacagg cagagcgagt tgatctcgta cagcgactgg tacatcagcc
     3901 aggtgcagaa gccgacgccg aagagcatgc cggcgttgag gccgagccag agccagcccc
     3961 ggtagcgggc cccggcgagg agcccggccc ccagggcgac gacgacggcg tacgtgacga
     4021 gtccgagcat cgggttgggg aagccgaaga cccccgcctg ctcgctcttc atgatgttgc
     4081 cgcaggagac gaccgggttc aggctgcacc cgggctggaa gccggggtcc tcgaggagct
     4141 tgaacttgtc gatcgtgatc acccagccgg acagcacgcc cgccgccccg gtgatcatca
     4201 gcagccaggc gagggcccgg cccgcgccga tcgtcccgtc cgtcccgtcg ccccgcgcga
     4261 gccgccgctg ccccggcacg ccctggacat ccaccgtcgc catgtcgccg ccgcccgcca
     4321 tccgctcagc cctgcagtcg ccggacgggc agcacgacgt gtgccccgcc cgccaggggg
     4381 tcctcgccgg cgaagaagga acgcagctgc tcctccgaga ccggctcacc gggcgcgacc
     4441 tgcggccagg ggcggaccga gcagaccagg taggcgtgcc cgagctcgtt ggcggccgcc
     4501 tcccactcgg ccggcaccga acactgcacc ttgatgaacg gcagggtgag gaccgcctgc
     4561 tgggcctcga cgaggaggtg ggcgtcgatg ccggactcct gggacgcgtc gaccacgggc
     4621 ccgccgacgg tgaggcccat gccctcgatg gcggcccgca tcgcttccac accggcctcg
     4681 cggccgtcgc gtccgttgcc gagcgaatac accatcaggt acggagcggc cggcttttcg
     4741 tcggtgggtc cggtggtcca gaagacggcc gagagcgtac ccagcgggga gatgctgcgc
     4801 gactcggaaa cgacattgga agaagtcatg ggtccggatg ctagtggcca cacgcccgcc
     4861 attccccatc ccattcaccc gaacggccga cattctcccg gcagcagttt tcaccacaac
     4921 gaatcggtgt ttttctcgtt gttctctcag ggcatttccg tccgcctgcg gcgggccgcc
     4981 ggaccaccag gagatcactc atgaccgtca cgcgccgcct cgcactgcgg tccctcttca
     5041 ccctgaccgc cgccgccttc accggtggcg cgctcgcccg tatcgccagg acgccccgga
     5101 gcggagcgcc cgccgccgcc gcgccgcccg acgggacctt cgacgagatg taccggggcc
     5161 gccgcatcca gggccggccg gcgccggccg acgggatcga ggtcctcgtc gacgaccggc
     5221 cgctgcatct gatgcgctgc gcggacggcg gctacctcac ccccatcgat cactaccaga
     5281 cctatccgac accgctggcg gccacgcgcg cggccgtgga cgagctcggg tccgcgccgc
     5341 tgacccgttt cgccgccgcc cacggcgtcc acaccgggag ggagtccgcg tggcctacac
     5401 acggaagaac cagcgtgatc tgaccagcgc cgagcgaagg aagttcgtcg ccgcggtcct
     5461 ggagctgaag cgcacgggga cgtacgacga cttcgtccgc acccacatcg actactacac
     5521 ggccgacggc gacggccggc tgcgcctggc ccacatggcg cccagcttcc ttccctggca
     5581 ccgcaagttc ctgctggagt tcgagcgggc gctgcgccgg gtcgacccca cggtcaccgt
     5641 cccgtactgg gactggaccc gcgacaacac ccccgccgcc tccctctgga acgacgactt
     5701 catgggcggc aacggccggc gcggtgacct ccaggtgatg accgggccct tcgcccactc
     5761 gggcggccgc tggaccatca cccacgggat gaccgaaggc gccttcctca cccgggacct
     5821 cggccacccc cgcgccccga tcaccctccc caccggggcg gacctcgacg tggtgatgcg
     5881 cgagacggtg tacgacgtgg ctccctggaa ctccacgagc acctccggct tccgcaaccg
     5941 cctcgaggga tgggccccgg gccggggcaa cgagcgcttc cgcgtccaca accgcgtgca
     6001 ccgctgggtc ggcggcctga tgctgggcgg cgcctcggtc aacgacccgg tcttctggct
     6061 ccaccactcc ttcgtcgacc tgatctggtc acgctggcag cagcgcaacc cgcgcgccgg
     6121 ctacgtgccg gcacaacccc cgccaccggg tgacgcgcag cacggccgga tcgcggcccg
     6181 caacgagcgg atgggcccgt ggggcgtcac cccggcgcag atgctcgacc acagcgcggt
     6241 ctaccggtac gcctgagggg ctgggtgcgc gcgcccccgc acgggaaagc ggccctccgg
     6301 cggatgtgcc gggggccgct ccatggggag ggggggatca gccgccgtag ccgccgtcgc
     6361 ggtcaccgtg gtcgtgaccg tcgacgttcg cgcaggagtt gccgaacgcc gggttgatca
     6421 gaccgatgac ggtgacggtg ttgccgcaca ggttcagcgg cacgtggacc gggacctgga
     6481 cgacgttgcc ggaggcgaca ccgggcgagt gggcggcgac ggcctcggcg cccgagtcgg
     6541 cgacggccag gccggctccg ctgagggcca cggcacccgt gccggcgaga acagcggcag
     6601 ccttcgcgat gcgagacatc aagaactcct tggacgtgga aagtcgaccg cgagtatcac
     6661 ggccgcacag ttcccttcaa cgccgaaaag gcggaccggt aacggccttt gggccggatg
     6721 gggcgtacgg gagaggggaa ggcccgcaga ccgggggccc ttccgccgcc ggatacgacg
     6781 gaccggacct ccggacctgc gggccgcggc catgcgacaa gccttctgtt gcaacgagca
     6841 acgacccttc gggttgcggg gaagaatcgt gtcttcatcc gccgggccat tggtcgtaca
     6901 aagggccctt gtcaggccgt cggctgcgcc aggcccagct ggggggccag caccccgttc
     6961 accgcggggg tgaggacgcc ggcgcccggc atcgtgaggt ccgggagccc gaacctgtcg
     7021 ccgcgcggca ggccgaccgg gttgccgacc gtggccccgg gggcggccgc ctccacgggc
     7081 gagctcgggg tggtcaacag ggccgtgccg ggccggctgc cctcgacggc ctcggggagc
     7141 ggggcggcga ggacggtgtt cgggagcgtg ctggagaccg gcacccgcgg caggccgatg
     7201 tccggcagag cctgggagtg cccctcgtgg aagacggtgg gggtgcccgg gacgggcagc
     7261 gggacaccgg tggccacggt cggcgcgtcc atggggatca ccggctccag accctggagc
     7321 gggacgacca ccggcgcctc ggcggcggag gcgggggcgg ccatggcggc cgaggcgaga
     7381 gcggtcatga gaattcccat gccggcttgt gatcgcaggt tcatgactgc gtgtgccctt
     7441 cggagggtgg tgacgacggt gcgatggagc tgtgtcctgt gaacgagccc tccggcagga
     7501 aagtcgcgaa aatcgcctac gtgcagcaac acccaaggtc cccaccggtg acggtgagga
     7561 ccttggttga cagggggtca gcccgacgcg tcagtggcga cgcccggagc gcccgacgcg
     7621 gaagcggacg accgctcccc cgaggatgag ggcggcactg acggccgcgg cgcccgtcag
     7681 cacggcggtg tcccgtccgg tgtcgggaag ctggggcacc cccggcccgc ccgaacccga
     7741 ctggctcgga ccgccgggcg gcttggtcga ctcaccgggg tgggtgggcg gcttcgtcga
     7801 ctcccccggg tgggtcggcg gcttcgtcga ctcaccgggc tcacccggct cgccgtgctg
     7861 acccggaggt gtcggcgaag cggtcggcgg cttggtcggc tcacccgggt gcgtgggatg
     7921 ccccggcttg gtcggctcgc caggcttggt cggctcaccc gggttcgtgg gatgccccgg
     7981 cccggtgggc tcacccggct tcgtcggctc acccggcttg gtcggctcac ccgggtgcgt
     8041 gggatgcccc ggtccggtgg gctcacccgg cttcgtcggc tcacccggct tggtcggctc
     8101 gccaggcttg gtcggctcac ccgggttcgt gggatgcccc ggcccggtgg gctcacccgg
     8161 cttggtcggc tcacccgggt gcgtgggata ccccggcccg gtgggctcac ccggcttcgt
     8221 cggctcaccc ggatgcgtcg gatgccccgg ccccgtcggc tcgccaggct tggtcggctc
     8281 acccgggttc gtgggatgcc ccggccccgt cggctcaccc ggcttcgtcg gctcacccgg
     8341 atgcgtggga tgccccggcc ccgtcgggtg cccgggaggt gccgggttct cgctcgggtg
     8401 gtcgggggtt tcgccgtccg ggccgtcccc gtagccgtcg gggtcgtcga cggcctgggc
     8461 gcagtggtca cggaccgccc tggcggcgat gtcgacgagc tgcacggagt ccccgcacag
     8521 gctcaccgag agggggacct gtcgatggtg ccccgcgccg ggccccggcg cgtcctccgt
     8581 ggagttcgcc gccacggcga agcctccggt cagcgacagg acgcccgtcg cggctgcggc
     8641 agtgagcagc ttcctggtga tgatggatcg cataccgctc ttcctctgga gaaagggaga
     8701 gaccggcggg gagccccctc gctccgaccg gcctttccgc gcacccagtg cgtcagtcgc
     8761 tgacgaactg gtcacggaac gcgggactcg gggacatcgg gcggatgcac cgccgcgacc
     8821 cccgagccga ccttccgtgg atgactggcc agagcgtaag gagcggtgca cggctaagaa
     8881 ccggacctcc acggcgacag atcagaaaat cattcgatca gccgatcact gcgacccgat
     8941 agggaaaggg cgtcagccgg ccagcgggag gccgccgagc agcggcacct tcttggtggt
     9001 ctcgttcagc ttcccggtga cctcgcccac ggcctggacc ggggagccgt ccgtggtgct
     9061 gctcagcgcg tcggtctgca ggccctcgct ggagatcacg tcgagtcccc cgtccaggct
     9121 ggtggggacc tccgccggcc ccatggccat ggcgggcgcg gcggcaccca gggccatgac
     9181 ggaaccggcg accatcgcgg cgaccttggt gggcttcatg gagtgagtcc ttcctctagg
     9241 catcttgagc gtcagtgcgt cttcgttgcg agcaagtcgc ttaccgcgcg actgagttga
     9301 gctttccacg cggtcttccg cttctgtaac gagaggcgtg ctccccggaa actccgggag
     9361 ggcgacactg cacccgaatg aagggtccgg tccgatttac cgatcggaaa ggcgaacgcc
     9421 gtaccggccc aggggtacgg ggccggtacg gcgtgatgcg tctgacgcgc ctagcggacg
     9481 gacgtcaacg actcggggac ggaagcgtcg gaagcgtagg gagcgccggg ggcgtcggca
     9541 gggcaggcaa gcccggcagg gccggcaggt cgatcgcggt gaggccgccg agcagggtgg
     9601 acacgatgag gtcgaccagg tcggcgacgg ccttctgcac ggtggcgccc gcgtcgccga
     9661 ggaggtcggc gggcacggcc tcggccgcga cgggtctcgc cacgaccgtc gcagcggcgg
     9721 gagcctccgc cttcggcggg gcgacggccg gcgtgtccgg tacggggagg tcgggaaccg
     9781 cggtggtggg cagtggcgcc atggcatcgg ccttggcggc ctcgaccgcc tgggcgatct
     9841 tggcgtcgaa cgcctcggag gcggcggtgg tgagccggcc gtcggccttg atcgacgcga
     9901 tgagctcggc caccgctgcg ctcaccgcct tcccgaggtc gccgagcccg gccggaaggg
     9961 cggcggtacg gccgatgggg gcctgggcgg cgacggtgga cgcgtggggc ggctggtgta
    10021 cgtcggcggc ggcgggtccc gccaagccga gggtgagggc ggcggatgca gccaggacgg
    10081 tgaggcggag tggtgcctgg ggacgcatat ttgttccttt tccgtatgcg tcggacaact
    10141 tccccttcac cgtgcctgcg cttatagcgc tccgcaatcg cagaactact gaacgccacg
    10201 catccgttcg ggtgaatcca cccctccgac ctgccactcc caggggcgta cgccgttgca
    10261 ccgggcggcg cacgacagtg cgcccgaacg agcgaaaggc cggcgcgcac accccggagg
    10321 ggtggcgcac cggcctcgga aggaccgcga tccgtgtgcg gtgtcaggcg ttgacgcagg
    10381 tgttgccgaa ggcggggttg agggcgccga tgacgttgac ggt
//
