LOCUS       NZ_JAIHBQ010000001     21113 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1876210
            Orig. end                         :: 1897323
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21113
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="12"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21113
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21113
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11113](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11113)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            complement(832..1866)
                     /locus_tag="K4902_RS08255"
                     /old_locus_tag="K4902_08255"
     CDS             complement(832..1866)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150625.1"
                     /locus_tag="K4902_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08255"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_221744805.1"
                     /transl_table=11
                     /translation="MKRPTMADIARRAGVSKVAVSYALNDQPGVSDATRAAIKSIAEEL
                     GWRPSSAARALTGGRALAVGLAVRRPARMLGVEPFFMEFISGVEAALSERSYALMLQMV
                     ADQEQEIELCRRWWGERRIDGVFLMDLQAEDARVPAVEALGLPAVVVGPPDASGSLPAI
                     WSDDGESIHEIVRYLAVLGHRHIARVAGPAELTHTRVRDRALRGACEEAGIPEAAVVHT
                     DYTGDAGARAARSLLIARERPTAIVFDNDIMAVAALSVAQELNLSIPGDLSIVAWDESP
                     LTQVVRPTLSAVTRDIPAYGARAANALLSLVVGETVDDIRDGYARFVPRGSTSPPSGGR
                     PGSS"
     gene            2184..3989
                     /locus_tag="K4902_RS08260"
                     /old_locus_tag="K4902_08260"
     CDS             2184..3989
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980828.1"
                     /locus_tag="K4902_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08260"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_221744806.1"
                     /transl_table=11
                     /translation="MPPPDFPLDHRYRGEHPVRTLAYLLRPDRVRLAGAVVVFFAKHAP
                     VWLLPPVTANVIDVVVEHGPPADLWWNCALMFTVLLLNPPLHLLYVRWAHGAVRRTGRD
                     LRCALVQRMQQLSIGFHSRTSSSVLHTKVVRDVETLENGLQQTADNGLTAVATLAGGLV
                     VIAVVTPAFLPVFLVLVPVSVLLIAALRSRLGDGNASYRRSVERMSTSVSDMTTLIPIT
                     RAHGLERTALRRVGHELDTVLREGSRLDLLNARFGSLSWVVFNGLGMGCLLGAALVAYH
                     GWLAVTPGEVVMLSAYFSTLTGAVTSLLTLAPVVGRAVESLKSVGEVLQDPDLEENDGK
                     VEVTTVEGGFCFEGVDLTYEGETGPALRGIDLVVPPGRTVAVVGGSGAGKSTLLNLVLG
                     FHRATHGRVLLDGRDMSELDLRSYRKFVAVVPQESVLFEGSIRDNVTYGMPDIDEETVR
                     RALADANATEFVDGLAHGLDTIVGERGARLSGGQRQRLAIARALLRDPRVLVLDEATSA
                     LDARSEALVQEALARLVAGRTVFVVAHRLSTVRNADRIVVLDQGRVQEVGTHAELLRRG
                     AAYARLQATQLAYPDGLPAGEHEGP"
     gene            4323..5588
                     /locus_tag="K4902_RS08265"
                     /old_locus_tag="K4902_08265"
     CDS             4323..5588
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0000272 - polysaccharide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038086.1"
                     /locus_tag="K4902_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08265"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_221744808.1"
                     /transl_table=11
                     /translation="MKKPSRGTWLTAVGAAIAGIAALVLPVLGPAGEAEAAPTGLRVRD
                     GRLYEANGNEFVMRGVNHAHAWYPERTGSLADIAEKGANTVRIVLSTGDRWTRTTADQV
                     SSLIGQCRTSKLICVLEAHDTTGYGEEPAAASLDRAADYWVGVKNALVGQEDYVVVNIG
                     NEPFGNNDQSAWTNATKNAIAKLRTAGLRHALMVDAPAWGQDWNHVMRDNAASVLAADP
                     DRNTIFSVHMYGVYDTAAEVQNYLNHFVSNRLPIVVGEFGDNHSDGNPDENAIMATAQS
                     LRVGYLGWSWSGNGGGVEYLDLVTGFDADSLTAWGNRLFHGANGISTTSKTATVYTGGQ
                     PAEDTARNGYPYCAPGSTSDPDGDGWGWESNRSCVIRGGSADTAPNGYRYCAQGSASDP
                     DGDGWGWESNRSCVVRHGSADR"
     gene            complement(5610..6848)
                     /locus_tag="K4902_RS08270"
                     /old_locus_tag="K4902_08270"
     CDS             complement(5610..6848)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017242118.1"
                     /locus_tag="K4902_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08270"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_260461848.1"
                     /transl_table=11
                     /translation="MDASDIDYEAVYHALPGAVALLTPDLVFVDANEAYLRLSGRTREQ
                     VRGRYLFDVFPDRPGEPAASGTRSLRDSLRRVVSTGDSDSMALHRYDVEDPDRPGVWEE
                     RYWSPINVPVLGPDGAVVLVLHRVEEVTELIRARGTRGGGDRSRVLEAELYTRARELQE
                     VNQRLRETHAREREVALHLQRAMLPAPGQLGHHRAAVRYRPATGALNVCGDWYDLIDMR
                     DPDRDRAAVAVGDVVGHGLPAAGVMGQLRSALSAASRVAAGPAQALDVLGLYARHVDGA
                     ESTTAVSVFIDWTGHTLTYSSAGHPPPVLCHADGTVTFLDRATDPPLGARPEHVARPQS
                     RTGFTDGSTLILYTDGLVERRREDIDTGLQRLADSAARHRAADPGDLADALLADLIPPA
                     GITDDTALVVVRL"
     gene            7224..8042
                     /locus_tag="K4902_RS08275"
                     /old_locus_tag="K4902_08275"
     CDS             7224..8042
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_08275"
                     /product="hypothetical protein"
                     /protein_id="WP_079197156.1"
                     /transl_table=11
                     /translation="MASEDCHRVRGDIRRDPTGGSAKKTSAGPIRSERLPVEFLDARRI
                     GFVELPAPALSPWERGEVARLWAETKARNPATFDGPLVASLGVDPPGPGPMLVRWARMP
                     YRYRALRKLRAPHDVPGSVFVTVLLPTEHGLAVGRGSPTTAAPGRWSLPGGSAEPPEAG
                     SPLDMEALRRHAAVELAEELGVHDAAEGLRLWGLTRGARFGSLGFHFLAPPLPSALVRR
                     LHADLTVAETERGDAPELDRVAFVSSPEQAARLGSGADYLHQVLVRYFPT"
     misc_feature    8115..8130
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            8218..9522
                     /locus_tag="K4902_RS08280"
                     /old_locus_tag="K4902_08280"
     CDS             8218..9522
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136892.1"
                     /locus_tag="K4902_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08280"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_221744812.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.3e-10, bitscore:
                     39.6, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FMO-like (E-value: 3.5e-78, bitscore:
                     262.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVCVIGAGLSGLAAAHALAVKGVDFVCLERAADVGGIWRRPAAG
                     EPGPGYRSLHLNTAKQLTGYTEFPMPDTYPLYPGHSQVAAYLRSFAEWAGVSDRIEFGV
                     EVVSVRQEGDDASWTVVSRGPDGTLQSRRFAHVVVASGHNTVPTLPKPAPPGSDGFAGR
                     ILHSVDYEDGADFAGQRVVVVGLGASAVDIATDLSRHAARTVLSVRRGLHIVPKQLYGM
                     SVDQMAEEPWFTAMSLPEQVEFATEALRVARGKLSDYGLPEPDHPLFSSPVTISDEILS
                     RIRHGAVTPRPGIDHLDGTRVVFTDGTSEEADAIVYCTGYGMDFPFLPEGCPAGPGGSV
                     ELYRRVVAPGRPGLYFVGLVRPMGAITRLVEGQTRWVARIIGGEVVLPDADAMREEIDA
                     YLGGIARRYGSAEGGTSIQVDVGPYLREMRELQDA"
     gene            complement(10001..11113)
                     /locus_tag="K4902_RS08285"
                     /old_locus_tag="K4902_08285"
     CDS             complement(10001..11113)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971675.1"
                     /locus_tag="K4902_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08285"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_260461849.1"
                     /sec_met_domain="indole_PTase (E-value: 3.9e-135, bitscore:
                     449.1, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLPDTTPEPEAGTLGAHTRAQLTRLCDVAGLSPTDAETYAHT
                     LVEALGPAAGRSLALPPPTRTFLSDDHTPVEYSLSFSPGRAPALRVLVEPGFGAGSWAE
                     NGRIGLEAVRAMARRWDFSTERLDEIEDLFFPARAKGPLALWIALELLPGGVPRMKVYL
                     NPAVKGAKRSAKTVRKALRRLGHRRAFKALPKADGHPFLALDLGRWETPRVKVYARHLG
                     LSAAEAGGLSRTGSGPGPAELQEFFRATAATDDLDRRPGLSCHAFTETETGRPSGFTLH
                     IPVRDYARDDREVLERSVDVLRSHGMDPDPLVRSLSALTSRRPKDGVGLIAYLALAHQQ
                     GHPPRVTAYLSSEAYAVRPPAKLPRAAAAV"
     misc_feature    11298..11311
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.02"
                     /tool="antismash"
     misc_feature    complement(11336..11351)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            complement(11340..12701)
                     /locus_tag="K4902_RS08290"
                     /old_locus_tag="K4902_08290"
     CDS             complement(11340..12701)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125674.1"
                     /locus_tag="K4902_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08290"
                     /product="cytochrome P450"
                     /protein_id="WP_221744814.1"
                     /transl_table=11
                     /translation="MDTHTPAPAPPPGCPAHGSGARVPLYGTEFAADPQAYYAYLRHYG
                     PTAPVELAPGVDATLVTDYQAALQLLQDSASFRKDARLWRDFNEGRVPRDSPVVPLLAY
                     RQNCMFSDGGEHLRLRQAITDSMARVDSHRLARSTERISDYLISQFGSRGSADLLGDYA
                     KQLPLFVFNELFGCPAGVGDRVLFGISGMFDGVNAEKATAVLFGAVQELVTLKRSRPGD
                     DVTSWLMQHQANLSDQEMVDQLSLLLGAGAEPLRNLLGNTLHRLLTDDRYADGGGLIGE
                     ALDDTLWDNPPMSNYAPHYPAADMEFAGEKVQAGDLMLVSFAAANSGLALTAARTAGSN
                     RSHLAWSAGPHGCPSKEPARHITVTAIEHLLNRLPDVELAVPEDSLIWRPGPFNRALAT
                     LPARFTPVPSSGGGDARPGTAAASSGAPFGAPSGQEGKGERKGRWSQFLSWLTN"
     gene            complement(12707..13309)
                     /locus_tag="K4902_RS08295"
                     /old_locus_tag="K4902_08295"
     CDS             complement(12707..13309)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="K4902_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08295"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_073817825.1"
                     /transl_table=11
                     /translation="MVSVPSLGERDYVRDGASQIPVKILVVGHFAVGKTTFIGSISEIE
                     PLTTEERMTQAAEHVDDLKGVRSKTTTTVAMDFGRLTISERIVLYLFGTPGQQRFVQMW
                     EDLARGALGALVLVDPERLADSFGVIDLIEQYGLEYAIAVNHFDGSPLRDEAALREALD
                     LLDDTPVVTCDARDEKSSADALTTLVRFLLDRARQEQ"
     gene            complement(13284..13658)
                     /locus_tag="K4902_RS08300"
                     /old_locus_tag="K4902_08300"
     CDS             complement(13284..13658)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="K4902_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08300"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_073817827.1"
                     /transl_table=11
                     /translation="MTGREEWEPAAELVRPYVITKGRGLPDEEQLSLITLVTVAPEEGQ
                     RPTRLSPEEQRLLDICAAGYLSVAEIAGHTRLPLGVVKILLAALTEGGYLITRSPVRRA
                     VLADREILEEVLNGLRAKFG"
     gene            complement(13655..14056)
                     /locus_tag="K4902_RS08305"
                     /old_locus_tag="K4902_08305"
     CDS             complement(13655..14056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="K4902_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08305"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_030215995.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARSNDYDKDNADRV
                     AAAMSGVQSLSRSLGFFCEDPRAQWRQTLVEFDGGWVFLISAGEGAYLGVSASPDVDMA
                     DITFRMQQLVGQLGKVLMTPPRENLGTRS"
     gene            complement(14053..15219)
                     /locus_tag="K4902_RS08310"
                     /old_locus_tag="K4902_08310"
     CDS             complement(14053..15219)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="K4902_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08310"
                     /product="ATP-binding protein"
                     /protein_id="WP_073817829.1"
                     /transl_table=11
                     /translation="MTEYIQNPLLWALSVLVLAAIAVLVRQRKAAKALRQQIDGLRSHY
                     SDLENHYTQSVEAAQEQAEEATKTVLKSAMRTLQGLAAEQQLVVSRLQSKYGESAMLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGRHRDVASVYDVVRSAQGRIRHFRRVEILSRVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINTRTVPKGVCIVVDDAGVGMSDEER
                     TRAEGLLSSNRVTGVSGLGNPPQFGFAVIGVLCERFGFEVSVDSSSPYGGVRAVLLLPH
                     ELLTSVPVQRPTAPPVTTPGVPHPGGPEAVPATDPTADGLPKRRRKRPMAIVPSSAPAQ
                     APSRSDAEAAAIMGAFQRGTQSGRASYPEAPDRTSSTSRASSEGHEVS"
     gene            complement(15553..16986)
                     /locus_tag="K4902_RS36140"
     CDS             complement(15553..16986)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070074.1"
                     /locus_tag="K4902_RS36140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sodium:proton antiporter"
                     /protein_id="WP_260461850.1"
                     /transl_table=11
                     /translation="MSGGSAWTGAAVAAVTIGYGLFSRRLASTPVSAPMVFAAFGVLIG
                     PIGLDVLDLGHDAGPVLTLVEAALALLLFTDAMTVRRRDLRADGYLPLRLLAIGLPLSI
                     AAGWLLAWPLLPGLTLWEFALLGAVLAPTDIALGKTASSSPRVPGPVRHGLEVESGLND
                     GLVLPFFVMFLAALPGTLASEEGVGGVFWRAIVVSGAVGLALGVVGARLLTLARARGWA
                     TGAWQQVVVLAVAFCAYSVATALDGSGFIATWTGGFAFGVTLRRTASAGGGRAAEERPS
                     DPAVERPSDPARERPADPAEERPAAPAAERPSDPAGERPADLAENLGGLLGTLSFLAFG
                     AVLLGPALEHLDWRIITYAVLSLTVVRMLPVALALVGSGLRLPTVAYVGWFGPRGLASV
                     VFGLLLVEEHVPGIELLGQVIAVTIGLSILLHGVSAPSFTDRYGNWFDAAQAGGADLRE
                     ARGTAEGLGKRRGGQRRLR"
     gene            17373..17639
                     /locus_tag="K4902_RS08325"
                     /old_locus_tag="K4902_08325"
     CDS             17373..17639
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005316351.1"
                     /locus_tag="K4902_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08325"
                     /product="hypothetical protein"
                     /protein_id="WP_073817831.1"
                     /transl_table=11
                     /translation="MAVNNPDQKAHTSFFARPAVRRLTPFILITAVALIFIFENRGDVR
                     IRLLIPEVTMPLWGALLIAWALGMLACAFTVRRRSSRHSGHHK"
     gene            complement(17717..17905)
                     /locus_tag="K4902_RS08330"
                     /old_locus_tag="K4902_08330"
     CDS             complement(17717..17905)
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025563.5"
                     /locus_tag="K4902_RS08330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08330"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_260461851.1"
                     /transl_table=11
                     /translation="MFLNCPPAKARWRTYGAAVGYLTLTARHSAKCLRPSGGSITNGAA
                     AVQWTCDGTTSQQLQAG"
     misc_feature    18051..18066
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            complement(18062..20995)
                     /locus_tag="K4902_RS08335"
                     /old_locus_tag="K4902_08335"
     CDS             complement(18062..20995)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330807.1"
                     /locus_tag="K4902_RS08335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_08335"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_221744816.1"
                     /transl_table=11
                     /translation="MRFTILGPVEAVAPGSAAPGLAPRHRAVLAYLLLHAGVAISTDRL
                     VEAMWGPLPPDSARAQIQTTVAAIRRMLRASEADRMLVTRPAGYVITPEPGQLDLDEFT
                     GLTAQASATSGDPGEAVDRIRAALALWRGEPLAGITAAYVEGARARLNGQLLTAVERLA
                     ELELARGRHDGLIEELTLHATANPLRERLCCQLMLALHRAGRQTDALHVARTFRATLAE
                     EQGLDPGHAFNKLEQDILRDAPDLRPPVTAPAKPQGGSFLPYDVPDFTGREDELDGLIR
                     LWSGDGGGVVTISAIDGMAGVGKTTLAVHAGHRLADRFPDGQLFVDLQAHTAGQEPLDA
                     GAALEILLSQLGVPAAQIPASVSDRSALWRSELSGRRVLTVLDNALGADQVRPLLPGAA
                     RALVLITSRRRLTDLDGAHALSLDVLPAADAVELFTAIVGERAAAEPLAVLDVLQLCGF
                     LPLAVRIAAARLHHRPRWTVAYLADRLRDQRRRLSELATSERGVAAAFTLSYEQLTPDQ
                     QRMFRLLGLQPGRDISAEAASTLADLPLDDAEMLLEDLLDAHVLAQHQLGRYTFHDLLR
                     EHALATAAAQEPAEARREALGRLFHHYLHTASTAIDHLYPEGRNRRPRIPAPDTPGSPP
                     RDEAEAITWLDGERANLMATGQYAAEHDWHSHTSRLAATLHRYLLGHAHQADAMALHGL
                     ALRAGRRSGDTAAEARTLLDLGEVHFWWHGAYEQAGEHYGQALDLARESGDRGAEARAL
                     QNLGTLSARRREYDRAEDHCTRSLGLFRQLGDRGGEARCLTDLGTVHERRGRYEDAHEH
                     HRQALRVYRETGSRIGEIIVLNNIGLLDQRQGRYDEARRRHREALELSRRYDFPGDEAE
                     SLNALAEAARSLGDLAGAATEHDTALTLAREFSYRPEQARAHAGLAYVHRDLGRVDLAR
                     DHAREALGLYLALAVPDADEIRAFLGGLPPTTNEHEAPEEATADGLS"
ORIGIN
        1 cgccacggtg gtggtcctgc tgccgctggc cgtcgtcttc ctgacctcgc tcaagacgtc
       61 ggaggaggtc ggagacgggg gcgcgctctc cctgccgggg aactggctga acctcgacaa
      121 ctacgtcacg gcgttcaccg acggccacat gctcatggcc ttcgggaaca ccgcgttcat
      181 cctgttcttc tccatcagcg gcaccgtgat catcggctcg atgacggcct acgcggtgga
      241 ccgcttcgac ttccgtgcca agaaaccggt catggcgctc ttcctgatcg ccaccctcgt
      301 gcccagcgtc accacgcagg tcgcgacctt ccaggtcatc agcggcttcg gcctggtcga
      361 cacccgctgg gccccgatcc tgctctacat gggcaccgac atcgtgtccg tctacatctt
      421 cctgcagttc atccgcggca tccccgtctc cctcgacgag gcggcccggc tcgacggcgc
      481 caacgccttc accatctacc gcaggatcat cttcccgctc ctgaagccgg ccatcgccac
      541 cgtcgtcatc atcaagggga tcaccaccta caacgacttc tacatcccct tcctctacat
      601 gcactccgag gacctgggga cgatctcgac cgcgctcttc cgcttcaagg gcccgttcgg
      661 cgcgcactgg gaggccatct cggccggcgc gatcctcgtc atcgtgccga ccctggtcat
      721 cttcctgctg ctccagcgct ggatctacaa cggcttctcg cagggagcca ccaagtagcc
      781 gcggagcggg aaggccgggc cgtcaggagg gtccgggcag gcgggcggac gtcaggagga
      841 tcccggccgc ccgcccgacg gcggggaggt gctgccccgg gggacgaagc gggcgtaccc
      901 gtcccggatg tcgtcgaccg tctcgccgac gacgagcgac aggagcgcgt tcgccgcgcg
      961 agccccgtac gccgggatgt cccgtgtgac cgccgacagc gtggggcgga ccacctgggt
     1021 cagcggagac tcgtcccagg cgacgatcga caggtccccg gggatggaga ggttcagctc
     1081 ctgcgccacg gagagcgcgg ccacggccat gatgtcgttg tcgaagacga tggccgtcgg
     1141 gcgttcccgc gcgatcagca gcgaacgggc cgcgcgggcc ccggcgtcac cggtgtagtc
     1201 ggtgtggacc acggccgcct cggggatccc ggcctcctcg cacgcaccgc ggagcgcccg
     1261 gtcccggacc cgcgtgtggg tcagttccgc ggggccggcc acccgggcga tgtgccgatg
     1321 gcccagcacc gcgagatacc gcacgatctc gtggatgctc tcgccgtcgt ccgaccagat
     1381 cgcgggcagc gagcccgagg cgtcgggggg cccgacgacc accgccggaa gaccgagggc
     1441 ctcgacggcg ggcacgcgcg cgtcctcggc ctggaggtcc atgaggaaca cgccgtcgat
     1501 ccgccgctcg ccccaccagc gccgacagag ctcgatctcc tgctcctggt ccgccaccat
     1561 ctgcagcatc agcgcgtacg aacgctccga cagggcggct tccacgccgc tgatgaactc
     1621 catgaagaac ggctccacgc cgagcatccg ggcgggcctg cgtaccgcga gccccaccgc
     1681 cagcgccctg cctccggtga gcgcgcgggc ggcgctgctg ggacgccacc ccagctcctc
     1741 ggcgatgctc ttgatcgcgg cgcgggtggc gtcggagacc cccggctggt cgttcaacgc
     1801 gtacgagacc gccaccttgg acacgcccgc gcggcgtgcg atgtccgcca tggtcggccg
     1861 cttcacgcgc cacccctgtc ctgtgctggt ccgtcgccgg tggtcgaccc taccgcccgc
     1921 ccgtaccgcc gggggaactc cgctcggcgg ccccgtggga cgcgaggggc gtcgatcgac
     1981 gccggctcac cgccgggcgc ccgcaccctc cggcgccccg cccccgctcc ccctctccgc
     2041 ccccacgctc ccgtgcacac tccccctccc cgcccccagc ttccgtgccc actccccctc
     2101 tcccctccct ctggaccgaa gacccactcc cctccctcag cgcaccgcgc accgcgcacc
     2161 gcgcaccgaa gagatgagtc cgcatgcccc cgcccgattt ccccctggac caccgctacc
     2221 gcggcgaaca cccggtccgc accctcgcct acctcctccg tcccgaccgc gtacggctcg
     2281 ccggcgccgt ggtcgtcttc ttcgccaagc acgccccggt atggctgctg ccgccggtga
     2341 ccgcgaacgt catcgatgtc gtcgtggagc acggtccccc ggccgacctg tggtggaact
     2401 gcgccctcat gttcacggtg ctcctcctca acccgccgct ccatctcctg tacgtacgct
     2461 gggcccacgg cgccgtccgc cgtaccggcc gtgatctgcg ctgcgcgctg gtgcagcgga
     2521 tgcagcagct gtccatcggc ttccacagcc gcaccagttc ctcggtgctg cacaccaagg
     2581 tcgtgcggga cgtggagacg ctggagaacg gcctccagca gacggccgac aacgggctga
     2641 ccgccgtcgc gaccctcgcc ggcggcctcg tcgtgatcgc cgtggtcacg ccggcgttcc
     2701 tgccggtgtt cctcgtgctc gtaccggtct ccgtccttct gatcgcggcc ctccgctccc
     2761 gcctcgggga cggaaacgcc tcctaccggc gctccgtcga gcggatgtcg accagcgtca
     2821 gcgacatgac cacgctcatc ccgatcaccc gcgcccacgg cctggagcgc accgccctgc
     2881 ggcgggtcgg gcacgagctg gacaccgtgc tgcgggaggg gtcacggctc gatctgctca
     2941 acgcccgctt cggctccctc tcctgggtcg tcttcaacgg gctcgggatg ggctgcctgc
     3001 tcggcgccgc cctcgtcgcc taccacggat ggctggcggt cacccccggc gaggtcgtca
     3061 tgctcagcgc ctacttctcc accctcacgg gcgcggtgac cagtctgctg acgctggcgc
     3121 cggtcgtcgg cagggccgtg gagtcgctga agtccgtcgg ggaggtcctc caggaccccg
     3181 atctggagga gaacgacggc aaggtcgagg tcacgacggt ggagggaggc ttctgcttcg
     3241 agggcgtcga cctgacctac gagggcgaga ccggtcccgc gctccgcggc atcgacctcg
     3301 tggtcccgcc gggtcggacc gtggccgtcg tcggcggatc gggcgccggt aagtccactc
     3361 tcctcaacct cgttctcgga ttccaccgcg ccacgcacgg ccgtgtcctt ctggacggcc
     3421 gggacatgag cgagctggat ctgcggagct accggaaatt cgtggccgtc gtaccccagg
     3481 aatcggttct cttcgaaggg agcatccggg acaacgtcac ctacggaatg ccggacatcg
     3541 acgaggagac cgtgcgccgc gcgctggcgg acgcgaacgc gaccgaattc gtcgacggac
     3601 tcgcccacgg cctcgacacg atcgtgggcg aacggggcgc ccggctctcc ggcggccagc
     3661 gccaacgcct tgccatcgcg cgagcgctcc tccgtgaccc ccgggtcctc gtcctcgacg
     3721 aggcgacctc tgcgctcgac gcacggtccg aggcgctggt ccaggaggcc ctcgcccgac
     3781 tggtcgccgg aagaacggtg ttcgtcgtgg cccaccggct ctcgaccgtg aggaacgcgg
     3841 accgcatcgt cgtcctggac cagggccgcg tccaggaggt cgggacccac gccgaactcc
     3901 tgcgcagggg agcggcctac gcgcgcctcc aggccaccca gctcgcctat cccgacggcc
     3961 tgccggcggg ggaacacgag ggaccgtaaa gcctttcggg gaatccgagc aaccctcagg
     4021 ggcgaaaacg acgagtttag cggcggttta tcattcacca cccaccggat gatccgggaa
     4081 agcacatcac tgctttcccg cctattgacg cgggaggaac tccgagtgcc tcatggtgaa
     4141 gagcaccgac cggaactcgt cgaccgccga gctctccgga cgccgcggtg tcccccactc
     4201 cgacgcgccg tcacccacgg tcgctccagg gcatgacaac gttgccaggg cggataccgc
     4261 actcgactcc cggcccgcgc cccagcgggc cggtcccccg tgaagcactc ctgaggagaa
     4321 gcatgaagaa gccatcgcgc ggaacctggc tgacagccgt cggcgcggcg atcgccggca
     4381 tcgccgctct ggtgctgccc gtcctcggcc ccgccggtga ggccgaggcc gcccccaccg
     4441 gactccgcgt cagagacggc cgtctgtacg aggccaacgg gaacgagttc gtgatgcgcg
     4501 gcgtcaacca cgcgcacgcc tggtacccgg agcggaccgg ttcgctcgcc gacatcgccg
     4561 agaagggcgc caacaccgtc cggatcgtcc tcagcaccgg cgaccggtgg accaggacga
     4621 ccgcggacca ggtctcctcc ctgatcggcc agtgcaggac cagcaagctg atctgcgtgc
     4681 tggaggcgca cgacacgacc ggatacggcg aggagcccgc cgcggcctcc ctggacaggg
     4741 ccgccgacta ctgggtgggc gtcaagaacg cgctggtggg ccaggaggac tacgtcgtcg
     4801 tcaacatagg caacgagccg ttcggcaaca acgaccagag cgcgtggacc aacgccacga
     4861 agaacgcgat cgccaagctc cgcaccgccg gcctccgcca cgccctgatg gtggacgccc
     4921 ccgcctgggg ccaggactgg aaccacgtca tgcgggacaa cgccgcctcg gtcctcgccg
     4981 ccgaccccga ccgcaacacg atcttctcgg tccacatgta tggcgtctac gacaccgccg
     5041 ccgaggtcca gaactacctg aaccacttcg tcagcaaccg actccccatc gtggtcggcg
     5101 agttcggcga caaccacagc gacggcaacc ccgacgagaa cgccatcatg gcgacggccc
     5161 agtcgctccg ggtcggctac ctcggctggt cgtggagcgg caacggcggc ggagtcgagt
     5221 acctcgacct ggtcaccggc ttcgacgccg actccctgac ggcgtggggc aaccgcctct
     5281 tccacggcgc gaacggcatc tccaccacct cgaagaccgc caccgtctac acgggcgggc
     5341 aacctgcgga ggacaccgcc cgcaacggct acccgtactg cgcccccggc agcacctccg
     5401 acccggacgg ggacggctgg ggctgggaga gcaaccgctc ctgcgtcatc cgcggcggat
     5461 ccgccgacac cgctcccaac ggctaccggt actgcgccca gggcagcgcc tccgaccccg
     5521 acggagacgg ctggggctgg gagagcaacc gctcctgcgt ggtccgccac ggctctgcgg
     5581 accgctgacg ccggagccct cgccgccggt cagagacgga cgacgacgag cgcggtgtcg
     5641 tcggtgatgc cggcgggagg gatcaggtcg gccaggagcg cgtcggcgag gtcccccggg
     5701 tcggcggcgc ggtggcgggc ggcggagtcc gcgaggcgct ggaggccggt gtcgatgtcc
     5761 tcgcggcggc gctcgacgag gccgtcggtg tagaggatga gcgtggagcc gtccgtgaag
     5821 ccggtccggc tctgcgggcg ggccacgtgt tcggggcggg cgcccagcgg cgggtcggtc
     5881 gcccggtcga ggaacgtcac ggtgccgtcc gcgtggcaga ggacgggcgg cgggtggccg
     5941 gcgctgctgt aggtgagggt gtggccggtc cagtcgatga agacagacac ggcggtggtc
     6001 gactccgcgc cgtcgacatg gcgggcgtag agaccgagga cgtcgagggc ctgcgcgggg
     6061 ccggccgcca ccctcgacgc cgcggacagc gcgctgcgga gctgacccat gactccggcg
     6121 gcgggcagtc cgtgaccgac gacgtcaccg acggcgacgg ccgcgcggtc gcggtcgggg
     6181 tcgcgcatgt cgatcaggtc gtaccagtcc ccgcacacgt tgagagcccc ggtggcgggc
     6241 cggtaccgca ccgccgcgcg gtggtggccg agctgaccgg gtgccgggag catcgcccgc
     6301 tggaggtgga gggcgacctc gcgttcgcgg gcgtgcgtct cgcgcagccg ctggttgacc
     6361 tcctggagtt cccgtgcgcg ggtgtacagc tcggcctcca ggacccgcga ccggtcaccg
     6421 ccgccgcgcg tgccccgggc gcggatgagt tcggtcacct cctccacgcg gtgcagcacc
     6481 agcaccaccg cgccgtccgg accgagcacc gggacgttga tcgggctcca gtaccgctcc
     6541 tcccacactc ccggccggtc cgggtcctcc acgtcgtagc ggtgcagcgc catgctgtcg
     6601 ctgtcgccgg tggacacgac cctccgcaac gagtcgcgca ggctgcgcgt accgctcgcg
     6661 gccggttccc cgggccggtc ggggaagacg tcgaacaggt agcgtcccct cacctgctca
     6721 cgggtgcggc ccgacagcct caggtacgcc tcgttcgcgt cgacgaagac caggtccggg
     6781 gtcaggaggg cgaccgctcc cggcagcgcg tggtagaccg cctcgtaatc gatgtcagaa
     6841 gcgtccacgc tgatctcctc cacgcgaatc cgctggtggc ggtggtgtat gtcgcggcga
     6901 tcaggtgaaa tcgaccggtc ccatgcgtcc attgcagcat cggccggaac gcttcgcacg
     6961 gcctcgggcg gtcccggggc cccggtgggc cggtggctcc cccgcatccc gacgggcggg
     7021 cggccgtcgc cgggggagac ggcccgggcg ccgtgacgtc ccgtagccgc ccgtggctcc
     7081 tcgcgtacgc cccgagaggc tgacgcccgc gcgggccggc gtgtccgcgt gcggttcatc
     7141 cacgtcggtg tcggtggccg ctgctacacc ggtgtcagca gggcgcgcgc cgatgcggcc
     7201 ctcatgtcgg gaggggacac gtcatggcgt ccgaggactg tcaccgggtg cggggcgaca
     7261 tccgccggga tccgaccggt gggtccgcga agaagacgag tgccgggccg atccggtccg
     7321 agcgtctccc cgtcgagttc ctcgacgcgc gacggatcgg cttcgtcgag ctgccggcac
     7381 cggccctgtc gccgtgggag cgcggcgagg tcgcccgcct gtgggcggag acgaaggccc
     7441 gcaaccccgc caccttcgac ggcccgctcg tcgcgagcct gggcgtcgac ccgccgggtc
     7501 ccgggccgat gctggtgcga tgggcgagga tgccgtaccg gtaccgggcg ctgcggaagc
     7561 tgcgggcgcc ccacgatgtt cccgggtccg tcttcgtcac cgtcctgctg ccgacggagc
     7621 acggcctcgc ggtcggacgc ggctccccca cgaccgcggc gcccggccgt tggagccttc
     7681 ccggcggctc ggcggaaccc cccgaggccg ggagcccctt ggacatggag gcgctccgca
     7741 ggcacgccgc ggtcgaactg gccgaggaac tcggcgtgca cgacgcagcc gaggggctgc
     7801 ggctgtgggg cctcacccga ggagcacggt tcggcagcct cggcttccac ttcctcgccc
     7861 cgccccttcc cagcgccctc gtgcggcgcc tgcacgcgga cctcaccgtg gcggagacgg
     7921 aacgcggaga cgctcccgaa ctcgaccggg tcgccttcgt gtcgtcaccc gagcaggccg
     7981 cccgcctcgg ctcgggcgcg gactacctgc accaggtcct ggtccgttac ttcccgacct
     8041 gaaccggcag accggtcccg cgggttgcgg aagctgtccg ggccggtcgg ggccggtcgt
     8101 cgtcggcaac gcgaacaccc ccgggggata acctgcggtg ttgcgcgtgt gaggcgtggg
     8161 gcgggtgggc agtgaatgat cgttcgagtg gagcgtgtct gttctgtggg ggaaaccttg
     8221 agtgtgtgcg tgatcggtgc ggggctgtcg ggactggcgg ccgcacacgc tctggccgtc
     8281 aagggcgtcg acttcgtctg tctggaacgg gccgccgatg tcggcgggat ctggcgccgg
     8341 ccggcggccg gtgagccggg gcccgggtac cggtcgctgc atctgaacac cgcgaagcag
     8401 ctcacgggct acaccgagtt cccgatgccc gacacgtacc ccctctatcc ggggcacagc
     8461 caggtcgcgg cctatctgcg gtccttcgcc gaatgggcgg gggtctcgga ccggatcgag
     8521 ttcggcgtcg aggtcgtgtc ggtgcgtcag gagggtgacg acgcgtcgtg gacggtcgtc
     8581 agccggggcc cggacgggac cctgcagtcg cggcggttcg cccatgtcgt cgtcgcctcg
     8641 gggcacaaca cggtgccgac gctgccgaag cccgcgccgc ccggctcgga cgggttcgcg
     8701 ggcaggatcc tgcattccgt cgactacgag gacggggccg acttcgccgg gcagcgcgtc
     8761 gtcgtcgtgg gcctcggggc gtcggcggtg gacatcgcca cggacctctc ccggcacgcg
     8821 gcgcggaccg tgctctcggt ccggcgggga ctgcacatcg tccccaagca gctgtacggc
     8881 atgtcggtcg accagatggc cgaggagccg tggttcaccg ccatgtccct gcccgaacag
     8941 gtcgagttcg ccacggaggc cctgcgtgtc gcgcggggca agctgtccga ctacggcctg
     9001 cccgagccgg accacccgct cttctcctcg ccggtgacca tctcggacga gatcctgagc
     9061 cgcatacgcc acggcgcggt gacccccagg ccggggatcg accacctcga cggcacgcgg
     9121 gtggtcttca ccgacgggac ctcggaggag gccgacgcga tcgtctactg caccggctac
     9181 ggcatggact tcccgttcct gcccgagggg tgcccggccg ggccgggcgg atcggtcgag
     9241 ctgtaccggc gggtcgtcgc ccccggcagg cccggcctct acttcgtcgg tctggtccgc
     9301 ccgatgggcg cgatcacgcg gctcgtggag ggccagaccc ggtgggtcgc gcgcatcatc
     9361 ggcggcgagg tcgtcctgcc ggacgcggac gcgatgcgcg aggagatcga cgcgtacctg
     9421 ggcggcatcg cccggcgtta cggctcggcg gagggcggca cctccatcca ggtcgacgtc
     9481 ggcccctacc tccgcgagat gcgcgaactc caggacgcct gaacccccgg ccgggccgcg
     9541 cgcccggccc cacgacggtg gagctcccgg tggacaccca ccgggaactc caccgtcgtg
     9601 ggggccgagg gaaacgtgac cgggccggcc gggagccgga acgacgaccc tcacgcgccc
     9661 gggcccgtac gaggcggggg ccatgaccag ggaccacgac caggggccac ggcaaagacc
     9721 ggggctgcgc ccccgaccgg accggcccac gacctcgacc cgcccgcgcg gcggccccga
     9781 cgacctcccg gctcacgccc ttgacccggc cgggccgcaa ccctgacctc ccggcccgcg
     9841 accccgcccc gcccgcgccg cgacccgacc tcccggcctg cgccctcgac gcgcccggcc
     9901 cgcgaccccg acccgcccgg gcaaacggcc cgaggccacg gcggagccgg gcccgcgatc
     9961 ctggtcatcc aaggccgcgg ccccgacttc ccggccctgc ctagaccgcc gccgcggcgc
    10021 ggggcagttt cgccgggggt cggacggcgt aggcctccga cgagaggtac gcggtcaccc
    10081 ggggcgggtg gccctgctgg tgggcgagcg cgaggtaggc gatgaggccc actccgtcct
    10141 tgggccgccg cgaggtgagc gcggacagcg accggaccag cgggtcgggg tccatgccgt
    10201 ggctccgcag gacgtccacc gaccgctcga ggacctcccg gtcgtcgcgg gcgtagtcgc
    10261 gcaccgggat gtggagggtg aagccgctgg ggcggccggt ctccgtctcg gtgaaggcgt
    10321 ggcaggacag gccgggccgc cggtcgaggt cgtcggtggc ggcggtggcc cggaagaact
    10381 cctggagctc cgccggcccc gggccggagc ccgtacggga caggccgccc gcctcggcgg
    10441 ccgacaggcc gaggtgccgg gcgtagacct tcacccgcgg tgtctcccac cggcccaggt
    10501 ccagggcgag gaagggatgg ccgtcggcct tcggcagcgc cttgaacgcc cgtcggtggc
    10561 cgagtcggcg cagggccttc cgcacggtct tggcggaacg tttcgccccc ttcaccgcgg
    10621 ggttcaggta caccttcatc ctgggcacgc cgccgggcag cagctccagc gcgatccaca
    10681 gcgccagcgg ccccttcgcc cgggccggga agaagaggtc ctcgatctcg tcgagccgct
    10741 cggtggagaa gtcccagcgc cgggccatcg cgcggacggc ctccaggccg atccggccgt
    10801 tctccgccca gctgcccgcg ccgaagcccg gctccaccag cacgcgcagg gccggggcac
    10861 ggccagggct gaaggagagc gagtactcga cgggggtgtg gtcgtcggag aggaaggtgc
    10921 gcgtcggcgg cggcagggcc agcgaccgcc cggcggccgg ccccagcgcc tccaccaggg
    10981 tgtgcgcgta cgtctccgcg tcggtcggcg agagtcccgc gacgtcgcag aggcgtgtca
    11041 actgggcccg ggtgtgggcg ccgagggtgc cggcctccgg ctccggagtc gtgtcgggca
    11101 gcaagcggct caccgacccc cgcccagaac acgaggcacg cacgaagata cccgccgaca
    11161 agggcgggta tcccggtgcg cacccccacg gggtggtggc tctgacaaag cggtgtcggt
    11221 ggatatgtgg tccacgacag ctcctctacc tcatacacaa cactgatgcc gcgacgatca
    11281 ctacccctgt gatcgatcgg atagtcatgc agagaggggg aggagaggga aatcgtggat
    11341 cagttggtca gccaggacag gaactggctc cagcggccct tgcgttcgcc cttgccctcc
    11401 tgcccggacg gggcgccgaa cggcgcgccg gacgaggcgg ccgccgtgcc cggccgcgcg
    11461 tcgccaccac ccgatgacgg gacgggggtg aacctggcgg gcagcgtggc cagggcccgg
    11521 ttgaaggggc cgggacgcca gatcaggctg tcctccggta cggcgagttc gacgtcgggc
    11581 agccggttga gcaggtgctc gatggccgtg acggtgatgt gccgggccgg ctccttggac
    11641 gggcagccgt gcggacccgc gctccacgcc aggtgcgacc ggttgctgcc ggccgtacgg
    11701 gcggccgtca gcgcgaggcc cgagttggcg gccgcgaagc tcaccagcat caggtccccg
    11761 gcctgtacct tctcgcccgc gaactccatg tccgcggccg ggtagtgggg cgcgtagttc
    11821 gacatcggcg ggttgtccca cagcgtgtcg tcgagcgcct ccccgatcag cccgccgccg
    11881 tcggcgtacc ggtcgtcggt gagcagccgg tgcagggtgt tgccgaggag gttgcgcagc
    11941 ggttcggcac ccgcgccgag gagcagggag agctggtcga ccatctcctg gtcgctcagg
    12001 ttggcctgat gctgcatcag ccaggaggtg acgtcgtcgc ccggccggct ccgcttgagc
    12061 gtgaccagtt cctgcacggc cccgaagagt acggcggtcg ccttctcggc gttcaccccg
    12121 tcgaacatcc ccgagatgcc gaacagcacc cggtcgccga cgccggcggg gcagccgaag
    12181 agttcgttga agacgaacag cgggagctgc ttggcgtagt cgccgagcag gtccgccgag
    12241 ccccgggagc cgaactggga gatcaggtag tcggagatgc gctcggtgct ccgggccagc
    12301 cggtgcgagt cgacccgggc catgctgtcc gtgatcgcct ggcgcagccg caggtgctca
    12361 ccgccgtcgc tgaacatgca gttctgccgg tacgcgagga ggggcacgac gggactgtcc
    12421 cgcgggaccc ggccctcgtt gaagtcccgc cacagccgtg cgtccttgcg gaacgacgcg
    12481 gagtcctgga gcagctggag cgccgcctgg tagtcggtga cgagggtggc gtccaccccg
    12541 ggggcgagct ccacgggcgc ggtgggcccg tagtggcgca ggtaggcgta gtacgcctgc
    12601 gggtccgcgg cgaactccgt gccgtacagc gggacccggg cgcccgagcc gtgggcgggg
    12661 cagccgggcg ggggcgccgg ggcgggggtg tgggtgtcca tggcggctac tgctcctgtc
    12721 gggcgcggtc cagcaagaag cggaccaggg tggtcagtgc gtcggcggac gacttctcgt
    12781 cgcgcgcgtc gcaggtgacg acgggggtgt cgtccagcag gtccagcgcc tcgcgcagcg
    12841 ccgcctcgtc ccgcaggggc gaaccgtcga agtggttgac ggcgatggcg tactcgagcc
    12901 cgtactgctc gatcaggtcg atgaccccga aggagtccgc gagccgctcg gggtcgacca
    12961 ggaccagcgc gccgagggcc ccgcgcgcga ggtcctccca catctgcacg aaccgctgct
    13021 gaccgggggt gccgaacagg tacaggacga tgcgttcgct gatggtcagg cggccgaagt
    13081 ccatggcgac cgtggtggtg gtcttgctcc ggacgccctt gaggtcgtcg acgtgctcgg
    13141 cggcctgggt catccgctcc tcggtggtca gcggctcgat ctcggagatc gagccgatga
    13201 acgtggtctt gcccaccgcg aagtgcccga cgacgaggat cttcaccggg atctgcgaag
    13261 ccccgtcgcg tacgtagtcc cgctcaccca aacttggcac ggagaccatt cagcacctcc
    13321 tcaaggatct cccggtcggc gaggacggcc cggcgcaccg gcgagcgggt gatgaggtag
    13381 ccgccctcgg tcagggcggc gaggaggatc ttcaccacgc cgaggggcag ccgggtgtgg
    13441 ccggcgatct cggcgaccga caggtagccg gcggcgcaga tgtcgagcag ccgctgctcc
    13501 tcgggcgaga gccgggtggg ccgctggccc tcctccggcg ccaccgtcac cagcgtgatc
    13561 agggagagct gttcctcgtc gggcaggccg cgtcccttgg tgatgacgta cggccggacc
    13621 agctcggcgg ccggctccca ctcctcgcgt cccgtcatga gcgcgtgccg aggttctcgc
    13681 gcggcggcgt catgagcacc ttgccgagct ggccgacgag ctgctgcatc cggaaggtga
    13741 tgtccgccat gtcgacgtcc ggggacgcgg agacgccgag gtaggcgccc tcaccggcgg
    13801 agatcaggaa gacccagccg ccgtcgaact cgaccagggt ctgccgccac tgcgcgcgcg
    13861 ggtcctcgca gaagaagccg agcgagcggc tcagcgactg caccccgctc atcgcggccg
    13921 cgacgcggtc ggcgttgtcc ttgtcgtagt cgttcgacct ggccatcagc aggccgtcgg
    13981 cggatatcag gaccgcgtgc agcgcgccgg gaatctccag ggcgctgtcg agcatccatg
    14041 acagatcgtc gttcacgaga cctcatgtcc ttcgctgctt gcacgagatg tgctgctcgt
    14101 ccggtccggc gcctccgggt aggaggcccg gccggactgc gtgcctcgct ggaaggcacc
    14161 catgatcgcc gccgcttcgg cgtcggagcg gctcggagcc tgtgcgggcg cactgctggg
    14221 cacgatggcc atcgggcgct tgcggcgccg cttgggcagg ccgtcggcgg tcgggtccgt
    14281 cgcgggcacg gcttcgggcc cgcccgggtg cggtacgccg ggtgtggtca cgggcggcgc
    14341 cgtgggcctc tgcaccggca cgctggtgag cagctcgtgc ggcagcagga ggaccgcgcg
    14401 gacaccgccg tacggggagg acgagtcgac ggacacctcg aaaccgaacc gttcgcacag
    14461 cacgccgatc accgcgaagc cgaactgcgg cgggttgccg agtccggaga caccggtgac
    14521 gcggttgctg gagagcagtc cctcggcgcg ggtccgttcc tcgtcgctca tgccgacgcc
    14581 cgcgtcgtcg acgacgatgc acacgccctt gggcacggtg cgggtgttga tctcgacgac
    14641 ggtgtcggga ctggagtagc tggtggcgtt gtcgaggagc tcggcgagcg ccagcgccac
    14701 cggttcgacg gcgcggctgg tgatgccgaa gtcgacgcgc gagaggatct ccacgcggcg
    14761 gaagtgccgg atccggccct gggcgctgcg gaccacgtcg tacacggacg ccacgtcgcg
    14821 gtggcggccg agccagccgt cgcagaggac ggcgatggac tgggcgcgcc ggccgaactg
    14881 cgagttggtg tggtcgatct ccagcaggtc ctggagcatg gcggactcgc cgtacttgct
    14941 ctggagccgg gagacgacga gctgctgttc ggcggcgagg ccctggagcg tccgcatcgc
    15001 ggacttcagg acggtcttcg tcgcctcttc ggcctgttcc tgcgccgcct cgacggattg
    15061 tgtgtagtgg ttctccaggt cggagtaatg gctccggagc ccgtcgatct gctgccgcag
    15121 agccttggcc gccttgcgct ggcggacgag gacggcgatg gcggcaagaa cgaggaccga
    15181 cagagcccag agcagcgggt tctgtatgta ttccgtcata agactctctt caggcgaccg
    15241 acggccagtt gctgaattcc cgtcaatgcg gtgcaccggc ggaccgcccg catcgggacg
    15301 cctgcccgga acacccctga agtcggaggt gttctcctgc gctcatccgc ccgccccgct
    15361 tgcgcgccga tcgtatcact gtgcgattta gtgatggccc gtcaatagac ggtctgacca
    15421 gtccagtcgg acggtacgcc acgcgctcgc gggcccacgg aaccgccccc tccggccgaa
    15481 gtcctgcgac ggaccgcgtc accccaggtc acgcccgccg aggggactcc ctccctgcgg
    15541 agcccgcccc gctcagcgaa ggcgtcgctg gccgccgcgc cgcttcccga ggccctcagc
    15601 cgtgccccgc gcctcgcgca ggtcggcgcc gccggcctgc gcggcatcga accagttgcc
    15661 gtagcggtcg gtgaaggagg gggccgacac gccgtgcagc aggatgctga gaccgatggt
    15721 gaccgcgatg acctgcccga ggagttcgat ccccggtacg tgctcctcca ccaggagcag
    15781 tccgaagacc acggaggcca ggccgcgggg cccgaaccag ccgacgtagg ccacggtggg
    15841 cagccgcagt ccggagccga ccagcgcgag agccacgggc agcatcctga cgaccgtcag
    15901 gctgagcacc gcgtaggtga tgatccgcca gtccaggtgc tcgagcgccg ggccgagcag
    15961 gaccgcgccg aaagccagga aactcagggt ccccagcagc ccgcccaggt tctccgccag
    16021 gtcggcgggc cgctcccccg ccggatcgga cggccgttca gccgccgggg cggcgggccg
    16081 ctcctccgcc gggtcggcgg gccgctccct cgccggatcg gacggccgtt caaccgccgg
    16141 gtcggagggc cgttcctccg ccgcccgtcc cccgcccgcc gacgcggtcc tgcgcagggt
    16201 gacaccgaag gcgaagccgc ccgtccaggt ggcgatgaag ccgctgccgt cgagggccgt
    16261 cgccacgctg tacgcgcaga aggccaccgc aaggaccacg acctgctgcc acgccccggt
    16321 cgcccagccc cgcgcccgcg cgagggtcag cagccgtgca ccgaccaccc ccagggccaa
    16381 gcccacggcg ccgctgacca cgatcgcgcg ccagaacact ccccccacgc cctcctccga
    16441 ggcgagcgtg ccgggaaggg cggcgaggaa catgacgaag aacggcagta ccaggccgtc
    16501 gttcaggccg ctctcgactt cgagcccgtg ccgcacgggc cccgggacac gtggactgga
    16561 ggacgccgtc ttgccgagtg cgatgtcggt aggcgcgagg acggccccga gcagcgcgaa
    16621 ctcccacagg gtcagccccg gaagcagggg ccacgccaac agccagcccg ccgcgatgct
    16681 caggggcagg ccgatggcca ggagacgcag gggcaggtag ccgtccgccc gcaggtccct
    16741 ccgccgtacc gtcatcgcat cggtgaagag caggagagcc agagcggcct cgaccagcgt
    16801 cagcaccgga cccgcgtcat gccccaggtc gaggacgtcc agcccgatcg ggccgatgag
    16861 cacgccgaag gcggcgaaca ccatcggagc ggagaccggt gtcgaggcca gccggcggga
    16921 gaacagcccg tagccgatgg tgacggccgc gacggcggcc ccggtccagg cgctgccacc
    16981 actcatgacg taccactttc tccgtgacgc gcgctgcgcc ccgcgccgca cgaacctgga
    17041 cgttcctccg cgggtcgcgc gaccgacccc ggtcgcctga cagccgcccc tgtgcgcgcg
    17101 agagccgtca tgtgcccatg ctgggcgact tccggacggt ccgcatctgc gtgaggacgt
    17161 cgagggcagc cggcgcacga tgcgcgtgcg gtccgtccac gaggcgcgca gcatggtggt
    17221 atgaccggtt tcgcggcgtc gtgccgctgc cgccgggcca tgacggcccg gagcccgagg
    17281 gcggggtgcg cgtccggcgc agctccacct gacagggcca tcgcgcccgg ccgcgtcgct
    17341 cgcaccgggg ggagcaccag tgagaggcaa tcatggccgt gaacaacccg gaccagaagg
    17401 cgcacacgtc gttcttcgcc cgccccgctg tccgtcgact cacgcccttc atcctgatca
    17461 ccgcggtcgc tctgatcttc atcttcgaga atcggggcga tgtcaggatc cgccttctca
    17521 ttcccgaggt gaccatgccg ctgtggggtg ccctgctgat cgcgtgggcg ctcggcatgc
    17581 ttgcctgcgc cttcaccgtg cgccgtcgtt ccagtcgcca ctccggacac cacaaatagg
    17641 aaggcgggcg gctgcgagcg gcccacgaga accgggcccc gatcacatgg accggggccc
    17701 ggacacgtct cgcgggtcag cccgcctgga gctgctggct ggtcgtcccg tcgcaggtcc
    17761 actggacggc tgccgcgccg ttcgtgatgg atccaccgct cggccggagg cacttggcgc
    17821 tgtggcgggc cgtcagtgtg aggtatccga cggcggcgcc gtacgtacgc caacgtgctt
    17881 tggcaggagg gcagttcaga aacacgcgcg tgaataccgg ctcacagccc ggacgcggta
    17941 cggagcagaa cgacggcctc agttgaagag cgaggtcacg gccctacgta ctcgaagacc
    18001 ccgccgtgcg ggtgtcgcag caccacctcg ccagatccgg cgaacagctc ggtgacggcc
    18061 ttcacgaaag gccgtccgcg gtggcctcct ccggcgcttc gtgctcgttc gtggtcggcg
    18121 gcagtccgcc gaggaaggcg cggatctcgt cggcgtcggg gacggcgagg gcgaggtaga
    18181 ggccgagggc ctcccgggcg tggtcgcgcg cgaggtcgac gcggccgagg tcgcggtgga
    18241 cgtacgccag gccggcatgg gcgcgggcct gctcggggcg gtaactgaac tcgcgggcca
    18301 gggtcagcgc ggtgtcgtgt tcggtcgcgg cccccgcgag gtcccccaga gagcgggcgg
    18361 cctccgcgag cgcgttcagc gactcggcct cgtcgccggg gaagtcgtac ctgcggctca
    18421 gctccagggc ctcgcggtgc cggcgccggg cctcgtcgta ccggccttgg cgctggtcca
    18481 gcagcccgat gttgttcagc acgatgatct cgccgatgcg ggaccccgtc tcgcggtaca
    18541 cgcgcagcgc ctgccggtgg tgctcgtgcg cgtcctcgta ccggcctcgg cgttcgtgga
    18601 cggtaccgag atcggtcagg cagcgggctt cgcccccgcg gtcgcccagc tggcggaaga
    18661 gcccgaggga ccgcgtgcag tggtcctcgg cccggtcgta ctcccgtcgc ctcgcggaga
    18721 gggtgccgag gttctgcagg gcgcgggcct cggcgccccg gtcgccgctc tcccgcgcga
    18781 ggtcgagcgc ctgcccgtag tgctcgcccg cctgctcgta ggcgccgtgc caccagaagt
    18841 gcacctcgcc gaggtcgagg agcgtgcgtg cctcggcggc ggtgtcgccg ctgcggcgac
    18901 cggcccgcag ggccagaccg tggagggcca tcgcgtcggc ctggtgggcg tggcccagca
    18961 ggtagcggtg cagggtggcg gcgagccggc tggtgtggga gtgccagtcg tgctcggccg
    19021 cgtactggcc ggtcgccatg aggttcgcgc gttcaccgtc cagccaggtg atcgcctcgg
    19081 cctcgtcccg tgggggcgat cccggggtgt ccggcgcggg gatgcgcggc ctgcggttcc
    19141 tgccctcggg gtagaggtgg tcgatggccg tgctcgcggt gtggagatag tggtggaaca
    19201 gccggccgag ggcctcgcgc cgggcctcgg cgggttcctg ggcggccgcg gtggcgaggg
    19261 cgtgttcgcg cagcaggtcg tggaaggtgt agcggcccag ctggtgctgg gccaggacgt
    19321 gtgcgtccag caggtcttcc aggagcatct cggcgtcgtc gagcgggagg tcagccagcg
    19381 tggatgccgc ctcggcgctg atgtcacggc ccggctgcag ccccaggagc cggaacatgc
    19441 gctgctgatc gggcgtcagc tgttcgtagg acagggtgaa cgccgccgcc accccccgct
    19501 ccgacgtggc cagctcggag agcctgcggc gctggtcgcg gagccggtcg gccaggtacg
    19561 ccacggtcca gcgggggcga tggtgcaggc gggcggcggc gatgcggacg gccagcggca
    19621 ggaagccgca caactgcagg acgtcgagga cggccagggg ctcggcggcc gcccgttcac
    19681 cgacgatcgc cgtgaacagc tccacggcgt ccgcggcggg cagcacgtcc agggacaggg
    19741 cgtgcgcccc gtccaggtcg gtcagccgtc ggcggctggt gatgaggacg agggcgcggg
    19801 cggctcctgg cagcaggggg cgcacctggt cggcgccgag ggcgttgtcc agtacggtca
    19861 gcacgcgacg gcccgagagc tccgaccgcc acagcgcgct ccgatcggag accgacgcgg
    19921 gtatctgcgc ggcgggcaca ccgagttggc tcaggaggat ctccagcgcg gcaccggcgt
    19981 cgagcggttc ctgtcccgcg gtgtgcgcct gcaggtcgac gaagagctga ccgtccggga
    20041 agcggtccgc gaggcggtgt ccggcgtgga ccgcgagcgt cgtcttgccg accccggcca
    20101 tcccgtcgat cgcggagatc gtcacgacgc cgccgccatc gcccgaccac aggcggatca
    20161 gcccgtcgag ctcgtcctcg cggccggtga agtccgggac gtcgtacggc aggaagctgc
    20221 ccccctgcgg cttcgccggc gcggtgaccg gcggccgcag gtcgggggcg tcccgcagga
    20281 tgtcctgttc cagcttgttg aacgcgtggc cggggtccag cccctgttcc tcggccaggg
    20341 tcgcccggaa cgtccgtgcc acgtgcaacg cgtcggtctg ccgtccggcg cggtgcaggg
    20401 cgagcatcaa ctggcagcag agccgttccc gcagggggtt ggccgtcgcg tggagggtca
    20461 gctcctcgat gaggccgtca tgccgccccc gggccagttc cagctcggcc aggcgctcga
    20521 cggcggtcag cagctgcccg ttcagacgtg ctcgggcacc ctcgacgtac gcggcggtga
    20581 tgccggccag cggctccccc cgccacaacg ccagggcggc acgtatccgg tccaccgcct
    20641 ctcccgggtc gccggaggtg gccgacgcct gcgcggtcag gccggtgaac tcgtccaggt
    20701 cgagctgccc cggctcgggg gtgatcacgt aaccggccgg ccgcgtcacc agcatccggt
    20761 cggcctccga ggcgcgcagc atccgtcgga tcgcggcgac cgtggtctgg atctgcgcgc
    20821 gggcggaatc cggcggcaac ggcccccaca tcgcctcgac caggcgatcc gtactgatcg
    20881 cgacccccgc gtgcagcagc aggtacgcga gcaccgcacg gtgacggggt gccagaccgg
    20941 gcgcggccga accgggagcc acggcctcca ccgggccgag gatcgtgaac cgcatgccgt
    21001 cgctccaggg gtcgcccgca cgtgcatcga agacgcatcg ggaatgtatc aagatcaacc
    21061 ggcatggttc tcggcatgca aggacttcac atcgtggaac cggagatcac gac
//
