LOCUS       NZ_JAIHBQ010000001     11482 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1654819
            Orig. end                         :: 1666301
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11482
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11482
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11482
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6482](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6482
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            310..1191
                     /locus_tag="K4902_RS07345"
                     /old_locus_tag="K4902_07345"
     CDS             310..1191
                     /GO_function="GO:0016776 - phosphotransferase activity,
                     phosphate group as acceptor [Evidence IEA]"
                     /GO_process="GO:0006797 - polyphosphate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238114.1"
                     /locus_tag="K4902_RS07345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07345"
                     /product="PPK2 family polyphosphate kinase"
                     /protein_id="WP_073817466.1"
                     /transl_table=11
                     /translation="MPKHDGTGKRSTRPEPALREVLRVPGGDRVDLTAYDPSAIPAGPA
                     GKTAGLAATAALAPRLADLQERLYASSTAGDRRRVLLVLQGMDTSGKGGTVKHVIGQFN
                     PSGCRVHAFKKPTQEERSHPFLWRITKALPGPGEIGIFDRSHYEDVLIARVRELVPRAQ
                     LDRRYEQINRFEASLAEEGVTVVKVFLHLSYEEQRERLLERLDNPEKHWKFNPGDIEER
                     ALWPAYREAYEIALARCNSDEAPWYLVPADRKWYRNWAISTLLLEHLQELDPRYPPGDY
                     DVDACRRRLLET"
     misc_feature    1227..1241
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.4"
                     /tool="antismash"
     misc_feature    1256..1269
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.93"
                     /tool="antismash"
     misc_feature    1257..1270
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.72"
                     /tool="antismash"
     misc_feature    complement(1258..1271)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.92"
                     /tool="antismash"
     gene            1270..2109
                     /locus_tag="K4902_RS07350"
                     /old_locus_tag="K4902_07350"
     CDS             1270..2109
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238115.1"
                     /locus_tag="K4902_RS07350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07350"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_073817467.1"
                     /transl_table=11
                     /translation="MAALGLLGAVLVGCGGGTAETTLSGRPAAPSAGAAVGGPKPARVP
                     AAPPTMAPGPGGLTPVYERRTKGTEKVVALTFDADMTADQGPRAARGERFDNPELIATL
                     RRLKVDATVFMTGRWAEEYPEQARSIGGDPRFEIANHSYSHYAFATPCYGLPTVPGPDM
                     TADVQRAFDAFRDAGALNVVPYFRFPGGCYDDAALRALAPAGVTAVQWDVVSGDAFAKD
                     ADAVAEQVLDGVRPGSLVVLHCTRSAAPVTERAIRRIVPELRARGYRFVKVSELMSR"
     gene            complement(2116..2301)
                     /locus_tag="K4902_RS07355"
                     /old_locus_tag="K4902_07355"
     CDS             complement(2116..2301)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445326.1"
                     /locus_tag="K4902_RS07355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07355"
                     /product="hypothetical protein"
                     /protein_id="WP_073817470.1"
                     /transl_table=11
                     /translation="MSESTSSCAPEPGPRPEPAAEGPFAACVLCQEPTEYAESTKGITL
                     CPVCEWREAERTACSG"
     gene            complement(2316..2966)
                     /locus_tag="K4902_RS07360"
                     /old_locus_tag="K4902_07360"
     CDS             complement(2316..2966)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238116.1"
                     /locus_tag="K4902_RS07360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07360"
                     /product="ABC transporter"
                     /protein_id="WP_073817472.1"
                     /transl_table=11
                     /translation="MTALLRYQTGLLLRSQRWLAPFLLYAAFVGVGVDPGEPVLGALGF
                     AAAALLPVTAWSVRICLTQEPPAARSVVAAAAGRDRAHLAALLTGTALPALVGAVAVLA
                     VTALCNRRGITALAATTTGLLATLACALTGAAVGALSSRPFVPAAGWSLAALVLGSLLA
                     LVTTGSPAKHAMTALISGSRTATADPPWLACAGAVLLAAAAAALACRATARLE"
     gene            complement(<3368..4093)
                     /locus_tag="K4902_RS36700"
                     /old_locus_tag="K4902_07365"
                     /pseudo=""
     CDS             complement(<3368..4093)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852476.1"
                     /locus_tag="K4902_RS36700"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07365"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLERVGRRHGLRGPWVLREVDLHLPAGTLVRIVGTNGTGKSTLL
                     RLVAGVDAPGEGRVTGRPARTAYVPERFPAALPFTAADYLVHLARIQGLGRAAARAAAG
                     EWLERLGAAEHAGTDMARLSKGSSQKIAVAQALLADPALLVLDEAWTGLDTGARAELDA
                     AVRERRSAGATVVFVDHDPRRLAGEADAVYAVESGRVRETRQPDRPPTGPHGTAVPGDR
                     HGTTAPGHPAPAPGRLTPAP"
     gene            4223..4918
                     /locus_tag="K4902_RS07370"
                     /old_locus_tag="K4902_07370"
     CDS             4223..4918
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657150.1"
                     /locus_tag="K4902_RS07370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07370"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_260461838.1"
                     /transl_table=11
                     /translation="MSSSDTDLRDEKPQFVLPLVVRMEREAPPSRTDALETAARAVLEI
                     LTDARSLGDGEWAQVMTDWQDARIRKVVRRARGAEWRRADALPGITVTGEEAEVRVFPP
                     VPLDGWPKDLARLQVSGTELDDPAAPGPVPEGAAVLWFNPGLGMSAGKAMAQAGHGAQL
                     LWWAMTEDEREAWREAGFPLAVRTAAAGDWAGLTSSGLPVVRDAGFTEIAPGSCTVVSA
                     FPRPRRNLK"
     gene            5001..6482
                     /locus_tag="K4902_RS07375"
                     /old_locus_tag="K4902_07375"
     CDS             5001..6482
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888544.1"
                     /locus_tag="K4902_RS07375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07375"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_221744672.1"
                     /sec_met_domain="DUF692 (E-value: 4e-93, bitscore: 310.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELGIGIGWRPEIAEAVEGLSGVDWVEVVAENICVGHLPDSLTR
                     LRERGVTVVPHGVSLGLGGADRPDPARLAALGEKAVALGAPLVTEHIAFVRAGGPLTAT
                     PLLEAGHLLPVPRTRDALDVLVENVRIAQDALPVPLALENIAALLSWPGEEMSEGRFLA
                     ELVERTGVRLLVDVANLHTNHVNRGEDPARALSELPVEAIAYVHVAGGVERDGVWHDTH
                     AHPVPEAVLDVLAELASRVSPPGVLLERDDDFPPAAELAGELEVIATAVGMRSAGATGV
                     PRDDVPERVGAAHLHGAPHPAPAPLVASAAQPLLIGAGARVSGGAMPGVADAGTVDGDG
                     LGGDGFHGDALDGGRDTDAARQRLGLAQASLLSALVAGTPVPEGFDSRRLGVQSRALAA
                     KRADVVAKVAPELPEILGGAFRQAFLAYARSRPMTGGYRRDALDFAEHLLVAGRPEDPV
                     ARRRLTRWWQDRSGSRPPGRATRLVRAARHALAGR"
     gene            6490..7551
                     /locus_tag="K4902_RS07380"
                     /old_locus_tag="K4902_07380"
     CDS             6490..7551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956906.1"
                     /locus_tag="K4902_RS07380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07380"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_073817479.1"
                     /transl_table=11
                     /translation="MSALIALFYLAAAVGITLVVTRVVRMRGGPGGPVHDRYEVAFLNG
                     GPARVVDSALAGLHWDGRIAVGGPGIVGVVRPVAHDPVERAVFEAHAAAPHGALHHLRL
                     AVMRHPAVQEVGDGLAARGLVVSPATRRTTAWWCAGLGFTAFVLFPVSVVLTVVDLAST
                     SGSSVPFVFAVLPALLACGVTAIVCGALSSGQVTAAGRNALFGYGRTYGHLTDAGHLVA
                     RHGLRALPDPVLREQLLAAARFYGPVRRGGRRTAPAVTTWDAADDSGAAAVWCAGSSSC
                     GGGGSGSGGSGSCSAGSCSGGVSCSGGGSGWGGGGSSCGGGGGGSSCSSSSSGGSSCSS
                     SSSGSSCSSSSSS"
     gene            complement(7706..8419)
                     /gene="hemQ"
                     /locus_tag="K4902_RS07385"
                     /old_locus_tag="K4902_07385"
     CDS             complement(7706..8419)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962204.1"
                     /locus_tag="K4902_RS07385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07385"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_073817481.1"
                     /transl_table=11
                     /translation="MSAPEKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRGGYADE
                     VQELFDQLAAKDITVRGTYDLSGLRADADVMIWWHAETSDELQEAYNLFRRTRLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADENPRDYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGFPDVRANTVASFSLGDYEWLLAFEADELHRIVDLMRHLRASEARMHVREEVPFY
                     TGRRKSVADLVAGLA"
     gene            complement(8437..9900)
                     /gene="hemG"
                     /locus_tag="K4902_RS07390"
                     /old_locus_tag="K4902_07390"
     CDS             complement(8437..9900)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238123.1"
                     /locus_tag="K4902_RS07390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07390"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_221744674.1"
                     /sec_met_domain="DAO (E-value: 3e-11, bitscore: 42.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADTTGPHVVVAGGGITGLAAAHRLALAGHRVTLLEAGPRLGGK
                     LLAGEIAGAPVDLGAESLLARRPEAVALARAVGLGDRLQAPATTTASVWSRGELVPMPK
                     GHVMGVPGDAHAVEGLLSEEGVRRIALDGEQPPTEIGEDIAIGAYVADRMGHEVVDRLV
                     EPLLGGVYAGDAYRISMRAAVPALFEAARKHPTLTAAVRAVQQAGAAVPADAAGAATGL
                     GGSVFLGVDGGVGTLPAAVADAIRAAGGEILTDAPVTALRRTGPTGWQVVSGDRVLAAD
                     AVVVATPAGPAAALLAAHAPAAAAELDAVAYASMALVTLAFRRSDMPALAGSGFLVPPV
                     DGHTIKASTFSSQKWRWVTDGAPDLFVLRTSVGRHGEEDQVHREDADLVAASLKDLAAA
                     TGLTARPVATTVTRWLGGLPQYPVGHLARVARVREAVAALPGLRIAGAAYDGVGVPACI
                     ASAHRAADEIADEIIATSKRADPGAGHSR"
     gene            10049..11026
                     /locus_tag="K4902_RS07395"
                     /old_locus_tag="K4902_07395"
     CDS             10049..11026
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824201.1"
                     /locus_tag="K4902_RS07395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_07395"
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_221744675.1"
                     /transl_table=11
                     /translation="MRDTRATARARAAAAAALLTAVLVVTGCGAGGTATSGDAKRDLGA
                     AEAPARGAADGSSGSEQAAAPKAPAQQHVIRTASLSVEVADVTKAVATARRVTAGADGR
                     VENESTERIDDSHVASHLVLRVPQERYDTVLTELAGTGKLLGRKADAKDVTEQVVDVES
                     RIATQRASVARVRALMQRAEKLADVVTLEGELSRRQSDLEALLAQQSSLKDRTSMATIT
                     LHLTEKQKQAPTPAEEGRPGFGDALSGGWNALVGVVTWIGIILAALAPWLAVALIAFAL
                     WHRLIRPRRAARTPQASPTPPEAPRNAAGAPMAPEPPAAPGTGE"
ORIGIN
        1 ggacggcgac ggggcgcagc acgtctacgg ggtgagcagg aagggcgagg tgtacgcgct
       61 cgcccggggc gcgcggaaca tcggcacccc ggaggctccg gagtgggggg agttcgcggg
      121 cgtcaccttc tcgcccgacc ggcagacgat gtacgtgaac tgctacaccc ccgggacgac
      181 gttcgccgtg acgggtccgt ggtgctgacc tgaccccgtt ccggcccggc cgtccgcact
      241 cgcgggcggc cgggttccgt cgcaggatcg ggggaagacg ggcggcgacg cggcggagag
      301 gggaacggga tgccgaagca cgacggaacg ggcaagcggt cgacgcgccc ggagccggcc
      361 ctccgggagg tgctgcgggt ccccggcggc gaccgggtcg acctcaccgc gtacgacccc
      421 tcggcgatcc cggccggccc cgccggcaag acggccggcc tggccgccac cgccgccctc
      481 gcgccccgtc tggcggacct ccaggaacgc ctgtacgcgt cgagcacggc cggcgaccgc
      541 cgacgcgtcc tgctggtcct ccagggcatg gacaccagcg gcaagggcgg cacggtcaag
      601 catgtgatcg gccagttcaa cccgtccggc tgccgtgtcc acgccttcaa aaagccgacc
      661 caggaggaac ggagccaccc cttcctctgg cggatcacga aggcgcttcc cggtccgggc
      721 gagatcggca tcttcgaccg ctcgcactac gaggacgtcc tcatcgcgcg cgtgcgggag
      781 ctggtcccgc gagcgcagct ggaccgccgc tacgagcaga tcaaccgctt cgaggcgtcc
      841 ctcgcggagg agggcgtgac ggtcgtcaag gtcttcctgc acctctcgta cgaggagcag
      901 cgcgagcggc tcctggagcg gctggacaat cccgagaagc actggaagtt caacccgggc
      961 gacatcgagg aacgcgcgct gtggccggcg taccgcgagg cctacgagat cgcgctcgca
     1021 cgctgcaact ccgacgaggc cccctggtac ctggtcccgg cggaccgcaa gtggtaccgc
     1081 aactgggcga tcagcacgct gctcctggag cacctccagg agctggaccc gcggtacccg
     1141 ccgggggact acgacgtgga cgcgtgccgg cggcggctgc tggagacgtg acgcgagggc
     1201 actgccacgt tgcgagcttg agccacattg atcggataac ttccgatcgt gaacacttct
     1261 gtacgaaaaa tggcggcgct cggtctgttg ggcgccgttc tcgtcggttg cggcgggggt
     1321 accgccgaga ccaccctgtc cgggcggccg gccgcgccgt cggcgggcgc cgcggtcggc
     1381 ggcccgaagc ccgcacgcgt cccggccgcg ccgcccacca tggcaccggg gcccggcggg
     1441 ctcacccccg tctacgagcg ccggacgaag ggcaccgaga aggtcgtcgc cctcaccttc
     1501 gacgccgaca tgacggccga ccaggggcca cgggccgcgc gcggcgaacg cttcgacaat
     1561 cccgaactca tcgcgaccct gcgccggctc aaggtggacg cgaccgtctt catgaccggc
     1621 cgctgggcgg aggagtaccc cgagcaggcc cggtccatcg gcggcgaccc gcgcttcgag
     1681 atcgccaacc actcctacag ccactacgcc ttcgcgaccc cctgctacgg gctcccgacc
     1741 gtcccgggcc ccgacatgac ggccgacgtc cagcgggcct tcgacgcctt ccgcgacgcc
     1801 ggggccctca acgttgtccc gtacttccgc ttccccggcg gctgctacga cgacgcggcc
     1861 ctgcgcgccc tcgcgcccgc cggggtgacg gcggtccagt gggacgtggt cagcggggac
     1921 gccttcgcga aggacgcgga cgccgtcgcc gaacaggtcc tggacggggt acgacccggc
     1981 tccctggtcg tcctgcactg cacgcgcagc gccgcgcccg tcaccgagcg ggcgatccgc
     2041 cggatcgtcc cggagctccg ggcccgcggc taccgcttcg tgaaggtctc cgagctcatg
     2101 agccgctgac ggggctcagc cggagcaggc cgtgcgctcg gcctcccgcc attcacacac
     2161 ggggcacagc gtgatgccct tcgtcgactc ggcgtactcg gtcggctcct ggcacagcac
     2221 gcacgcggcg aacggtccct ccgccgccgg ttcgggcctc gggccgggct cgggcgcgca
     2281 ggacgacgtg gattcgctca tgtcttcgag cgtactcact ccagccgtgc ggtggcccgg
     2341 caggcgaggg cggcagcggc ggcggccagg agcacggcac cggcgcacgc cagccacggc
     2401 gggtccgcgg tggccgtgcg ggagccgctg atcagggccg tcatcgcgtg cttcgccggg
     2461 gagccggtgg tcaccagggc gagcagcgag ccgaggacga gggccgcgag cgaccagccg
     2521 gcggcgggga cgaagggccg ggagctcagg gcgccgacgg cggcgcccgt cagggcgcag
     2581 gccagggtcg cgaggagacc cgtggtcgtg gcggcgagcg ccgtgatgcc gcgccggttg
     2641 cacagcgccg tcaccgcgag cacggcgacc gcgccgacca gcgcgggcag ggcggtcccg
     2701 gtgaggagcg ccgcgagatg cgcgcggtcc cggccggccg ccgccgcgac cacgctccgg
     2761 gccgcgggcg gctcctgcgt cagacagatc cgcacggacc aggcggtcac cggaaggaga
     2821 gcggcggccg cgaacccgag agcgccgagc accggctcgc ccgggtccac gccgacgccg
     2881 acgaaggccg cgtacaggag gaacggcgcg agccagcgct gcgagcggag caacagaccg
     2941 gtctggtagc gcaggagcgc cgtcataccc gtacgccttc ggtggtgagg tggtggatgt
     3001 gccaggacgc cgcgaggagc gccccgagca gggcgtcgga atgggcggcg tccacggtga
     3061 ggacggtggt ggtgtcaccg ggctccggca cggagacgac gggatcaccg ggcagccgcc
     3121 ggggaagcgg ccccgcccca ccggagacgg cgatccgcac gagggagccc gatccggggg
     3181 cgggacgccc gggggcggcc gttccgtggc cgggcgcggc ggtgaggtgc ccgggggagg
     3241 ccgttccgtg gccgggcgcg ggggccgggt gtccgggggt cccgcggccg ggcgcggggg
     3301 tgaggcgccc gggggaggcc gttccgtggc cgggcgcggg ggccgggtgt gcgggggtcc
     3361 cgtggccggg cgcgggggtg aggcgcccgg gggcgggggc cggatgtccg ggggcggtcg
     3421 ttccgtgccg gtcacccggc accgccgtcc cgtgcggccc cgtggggggc cggtccggct
     3481 gtcgcgtctc gcgtacgcgg cccgactcca ccgcgtacac cgcgtccgcc tcgcccgcga
     3541 gcctgcgggg gtcgtggtcg acgaagacga ccgtcgcgcc cgccgaacgc cgctcgcgga
     3601 cggccgcgtc cagctccgca cgcgcgcccg tgtcgaggcc cgtccaggcc tcgtcgagga
     3661 cgagcagggc cggatcggcg aggagcgcct gcgccacggc gatcttctgg ctgctgccct
     3721 tggagagccg cgccatgtcc gtgccggcgt gctcggccgc tccgaggcgc tccagccact
     3781 cccccgccgc ggcccgcgcc gccgcccggc cgaggccctg gatccgggcc aggtggacca
     3841 ggtagtcggc ggccgtgaac ggcagggccg ccgggaagcg ttcggggacg tacgcggtac
     3901 gggccggacg gcccgtgacc cggccctcgc cgggcgcgtc gaccccggcg acgagccgca
     3961 ggagcgtgga cttgccggtg ccgttggtgc cgacgatccg gacgagcgtc ccggcgggca
     4021 ggtggaggtc gacctcacgc agcacccacg gcccccggag tccgtgccgg cgcccgaccc
     4081 gctccagcct caaccggccg cgttcttccg cggggtggcc tcgccggggc ggacgatcac
     4141 caagctcttc atgggggcat cctggcccgg aagggacgat caccacaaga acggctcgtc
     4201 accgcgatgg cagacttggc gggtgagcag cagcgacacc gatctccgcg atgagaagcc
     4261 ccagttcgtc ctccccctgg tcgtccggat ggagcgggag gcgcccccgt cccgtaccga
     4321 cgccctggag accgccgcgc gcgccgtcct ggagatcctc accgacgccc gttccctggg
     4381 cgacggggag tgggcccagg tcatgaccga ctggcaggac gcaaggatcc gcaaggtggt
     4441 gcggcgggcg cgcggcgccg agtggcggcg ggcggacgcg ctgccgggga tcacggtcac
     4501 cggcgaggag gcggaggtac gggtcttccc gccggtcccg ctcgacggct ggcccaagga
     4561 cctggcccgg ctccaggtct cgggcacgga gctcgacgac ccggccgcgc ccggccccgt
     4621 cccggagggg gcggcggtgc tgtggttcaa ccccggcctc gggatgtcgg cgggcaaggc
     4681 gatggcgcag gccggacacg gggcgcagct gctgtggtgg gcgatgacgg aggacgagcg
     4741 cgaggcctgg cgggaggccg ggttcccgct cgcggtccgg acggcggcgg ccggggactg
     4801 ggccggtctg acgtcgagcg gtctgccggt ggtgcgggac gcggggttca cggagatcgc
     4861 cccgggctcg tgcacggtgg tgtcggcgtt cccccggccg cgtcgcaacc tcaaatgaag
     4921 ctctgaacgt ccccctcctg gggttcgaac gttcccgcga gggccatcac gtgggtgact
     4981 gaggaccgaa ggagggggac atgacggaac tcggcatcgg catcggctgg cgtcccgaga
     5041 tcgcggaggc ggtggaggga ctgtccggcg tcgactgggt ggaggtcgtc gcggagaaca
     5101 tctgcgtggg ccatctgccc gactcgctga cccggctgcg cgagcgcggc gtgacggtcg
     5161 tcccgcacgg cgtctcgctg gggctcggcg gcgcggaccg gcccgacccg gcgcggctcg
     5221 ccgcgctcgg ggagaaggcg gtggcgctcg gggcgccgct ggtcacggaa cacatcgcgt
     5281 tcgtacgggc cggggggccg ctgaccgcga ccccgctgct cgaagcgggc catctgcttc
     5341 ccgtgccccg gacccgggac gccctcgacg tgctcgtcga gaacgtgcgg atcgcgcagg
     5401 acgcgctgcc cgtgccgctc gccctggaga acatcgcggc gctcctctcc tggccgggcg
     5461 aggagatgtc ggaggggcgg ttcctggcgg agctggtgga gcgcaccggg gtccggctcc
     5521 tcgtcgacgt cgccaacctg cacaccaacc acgtcaaccg gggcgaggac ccggcgcggg
     5581 cgctgtcgga actgccggtc gaggccatcg cgtacgtgca cgtggcgggg ggtgtcgagc
     5641 gggacggggt ctggcacgac acgcacgcgc accccgtgcc ggaggcggtg ctcgacgtgc
     5701 tcgcggagct cgcgtcgcgg gtgtcgccgc cgggggtgct cctggaacgg gacgacgact
     5761 ttccgcccgc ggcggagctg gcgggtgagc tggaggtcat cgccaccgcg gtgggcatgc
     5821 gttccgcagg ggcgacgggg gtcccccggg acgacgtccc ggagagggtg ggcgcggccc
     5881 atctgcacgg cgcgccccat ccggcgcccg cgcccctggt cgcctccgcg gcgcagccgc
     5941 tcctcatcgg tgccggggcc cgggtctcgg ggggtgcgat gccgggcgtg gccgatgccg
     6001 gcactgtgga cggtgacggt ctcggcggcg acggtttcca cggcgacgct ctcgacgggg
     6061 ggcgcgacac cgacgccgcc cgccagcgtc tcggcctcgc ccaggcctcg ctcctctccg
     6121 cgctggtggc cgggacaccc gtgcccgagg ggttcgacag ccggcggctc ggcgtgcaga
     6181 gccgggcgct ggcggcgaag cgggccgacg tggtcgcgaa ggtcgcgccg gagctgccgg
     6241 agatcctggg cggggccttc cggcaggcgt tcctcgccta cgccaggtcg cgccccatga
     6301 caggcggcta ccgtcgggac gcgctcgact tcgccgaaca cctgctggtg gccgggcggc
     6361 cggaggatcc ggtggcccgg cgccggctga cccggtggtg gcaggaccgt tccggcagcc
     6421 gccctccggg ccgcgccacc cggctcgtac gagccgcccg tcacgcactg gccggaaggt
     6481 gaggtgccca tgagcgccct gatcgccctc ttctacctcg ccgccgccgt cggcatcacg
     6541 ctggtcgtca cccgggtcgt ccggatgcgg ggcggacccg gcgggcccgt ccacgaccgg
     6601 tacgaggtcg cgttcctcaa cggcggcccg gccagggtcg tcgacagcgc cctcgccgga
     6661 ctgcactggg acggcaggat cgcggtcggt gggccgggga tcgtgggcgt ggtccggccg
     6721 gtcgcccacg acccggtgga gcgcgccgtg ttcgaggcgc acgccgccgc cccgcacggg
     6781 gcgctgcacc acctgcggct cgccgtgatg cggcacccgg ccgtccagga ggtgggcgac
     6841 ggactcgcgg cgcgggggct cgtcgtctcc cccgcgaccc ggcggaccac ggcctggtgg
     6901 tgtgccggtc tcggcttcac ggccttcgtc ctgttcccgg tgtcggtcgt cctgacggtc
     6961 gtggacctcg cctcgaccag cgggagctcg gtgccgttcg tcttcgcggt gctgccggcg
     7021 ctgctggcct gcggggtcac ggccatcgtc tgcggggcgc tctcgtccgg gcaggtcacc
     7081 gcggccgggc gcaacgcgct cttcgggtac gggcggacgt acgggcatct cacggacgcg
     7141 gggcatctgg tggcccggca cgggctgcgg gcgctgccgg atccggtgct gcgggagcaa
     7201 ctcctcgccg ccgcacggtt ctacgggccg gtcaggcgcg gtggacgccg tacggcgccc
     7261 gccgtcacga cctgggacgc ggccgacgac tccggagcgg cggccgtgtg gtgcgcgggg
     7321 agcagttcct gcggcggagg cgggagcgga tccggcgggt ccgggtcgtg ctccgcgggt
     7381 tcctgttcgg gcggggtctc ctgctccgga gggggctccg gctggggagg cggcggctcc
     7441 agttgcggag gcggaggcgg cggcagctcg tgctccagct ccagttccgg cgggagttcg
     7501 tgctccagct ccagttccgg cagctcgtgc tccagctcca gcagctcctg agatgacgcc
     7561 ggtgcggcgc gcttcacgcg cgccgcaccc ggagccggac ccggtgtcgc tggaccggca
     7621 ggcgttcccg cctgccgtct gatcttccgg gtcgagggtg gcgcacccgg ccggaagccg
     7681 ggccgccacc aggttcgtac ggccgtcagg ccaggcccgc caccaggtcg gcgacgctct
     7741 tgcggcgacc ggtgtagaac gggacctcct cgcggacgtg catccgcgcc tcggaggcgc
     7801 gcaggtgacg catgaggtcc acgatgcggt gcagctcgtc ggcctcgaag gcgaggagcc
     7861 actcgtagtc gccgagcgag aaggaggcga ccgtgttggc gcggacgtcc gggaagccac
     7921 gggccatctt gccgtggtcg gcgagcatcc ggcggcggtc ctcgtccggc agcaggtacc
     7981 agtcgtagga gcgcacgaag gggtagaccg agacgtagtc gcgggggttc tcgtcggcca
     8041 ggaaggccgg gatgtgcgac ttgttgaact cggcggggcg gtgcagcgcc atgttcgacc
     8101 agaccggctc cagggcgcgg cccaggcggg tgcgacggaa gaggttgtac gcctcctgga
     8161 gctcgtcgct cgtctcggcg tgccaccaga tcatgacgtc ggcgtcggcg cgcagaccgg
     8221 acaggtcgta cgtgccgcgg acggtgatgt ccttggccgc gagctggtcg aacagctcct
     8281 ggacctcgtc ggcgtaaccg ccgcggtcct cgggcaggac gtcgcgcagc ttgaagacgg
     8341 accacagggt gtagcggatg acctcgttga ggtccttcgc cttcttaccg gcgttcggga
     8401 tcttttcggg cgcactcata cgcctattct cgcccgtcac cgggagtgcc ccgcaccggg
     8461 gtcggccctt ttcgacgtgg cgatgatctc gtccgcgatc tcgtcggcgg cccggtgggc
     8521 cgaggcgatg caggcgggga caccgacgcc gtcgtacgcg gcgccggcga tccgcagtcc
     8581 ggggagcgcg gcgacggcct cgcggacccg ggcgacgcgc gcgaggtggc cgacggggta
     8641 ctggggcagg ccgccgagcc agcgggtgac cgtggtggcg acggggcggg cggtgagccc
     8701 ggtggcggcg gcgaggtcct tgagggaggc ggcgacgagg tcggcgtcct cacggtggac
     8761 ctggtcctcc tcgccgtgcc ggccgacgga ggtgcgcagc acgaacaggt cgggggcgcc
     8821 gtcggtgacc caccgccact tctgcgagga gaaggtggag gccttgatcg tgtggccgtc
     8881 gacgggcggc acgaggaagc cggagccggc cagggcgggc atgtcggagc ggcggaaggc
     8941 gagggtgacc agggccatgg aggcgtacgc gacggcgtcg agctcggcgg ccgccgcggg
     9001 cgcgtgcgcg gcgaggagcg cggcggccgg cccggcgggg gtggcgacga cgacggcgtc
     9061 cgcggcgagg acccggtcgc cgctgacgac ctgccagccg gtgggaccgg tgcggcgcag
     9121 tgcggtcacg ggggcgtcgg tgaggatctc gccgcccgcg gcgcggatcg cgtcggcgac
     9181 cgcggcgggc agggtgccga caccgccgtc gacgccgagg aagacggagc cgccgaggcc
     9241 ggtggccgcg cccgccgcgt cggcggggac ggcggcgccg gcctgctgga cggcgcggac
     9301 ggcggcggtg agcgtggggt gcttccgggc ggcctcgaag agggcgggga cggcggcccg
     9361 catcgagatg cggtaggcgt caccggcgta caccccgccg aggaggggtt ccacgagccg
     9421 gtcgacgacc tcgtggccca tgcggtcggc gacgtacgcg ccgatggcga tgtcctcgcc
     9481 gatctcggtc gggggctgct cgccgtcgag ggcgatgcgg cgcacgccct cctcggagag
     9541 gagcccttcg acggcgtggg cgtcgccggg gacgcccatg acgtggccct tgggcatggg
     9601 gacgagctcg ccgcgcgacc agacggacgc ggtggtggtg gcgggtgcct ggagccggtc
     9661 gccgaggccg acggcgcggg cgagggcgac cgcctcgggg cggcgggcga gcagcgactc
     9721 ggcgccgagg tccacgggcg cccccgcgat ctccccggcg aggagcttgc cgccgagccg
     9781 gggccccgct tcgagcaggg tcacccggtg gccggcgagg gccagccggt gggcggccgc
     9841 gagcccggtg ataccgcctc cggcgacgac gacatggggt cccgtggtgt ccgcgttcat
     9901 gggaccactc tctcaaatcg cccgccgctc ccgttccgag gccggaccgt gaccgcatcg
     9961 ctaccggccg ggggaaaccc gttccggggg cgcgtacgtc gaatcagcgt cgaagcgaca
    10021 acaccgatca ccaccctggg gggacgcgat gcgagacaca cgagcgaccg cgagagcgcg
    10081 ggcggcggcg gccgccgcgc tgctcacggc cgtactggtc gtgacgggct gcggcgccgg
    10141 cggcaccgcc acgagcgggg acgccaagcg ggatctgggc gcggccgagg cgcccgcccg
    10201 gggcgccgcc gacggctcct cgggcagcga gcaggccgcg gcgccgaagg ctcccgccca
    10261 gcagcacgtc atccggacgg cctccctctc ggtggaggtc gccgacgtga cgaaggcggt
    10321 ggccacggcc cgccgggtga cggcgggcgc ggacgggcgg gtcgagaacg agtcgacgga
    10381 gcggatcgac gacagccacg tcgcctcgca cctcgtgctg cgggtgccgc aggagcggta
    10441 cgacaccgtg ctcaccgagc tcgcgggcac cgggaagctc ctcggccgca aggcggacgc
    10501 gaaggacgtc accgagcagg tggtggacgt ggagagccgg atcgcgaccc agcgcgcgag
    10561 cgtggcgcgg gtccgggcgc tgatgcagcg cgcggagaag ctggcggacg tggtgaccct
    10621 ggagggcgag ctgagccgcc gccagtcgga cctggaggcg ctgctcgcac agcagtcctc
    10681 gctgaaggac cgcacgtcca tggcgacgat caccctccat ctgacggaga agcagaagca
    10741 ggcgccgacg ccggcggagg agggccgccc gggcttcggg gacgccctga gcggcggctg
    10801 gaacgccctg gtcggcgtgg tgacctggat cggcatcatc ctggccgccc tggcgccgtg
    10861 gctcgcggtc gccctgatcg ccttcgccct gtggcaccgc ctgatccgcc cccgccgcgc
    10921 ggcccggacg ccccaggcct cccccacccc gccggaggcc ccgcgcaacg ccgccggggc
    10981 gccgatggcg cccgagccgc ctgccgcccc cggaaccggc gagtgagccg aaggggcgcg
    11041 ccggggcaac gggcccgagc gcgcggagcc tcctgaggaa cgaaggaggc gagcacggtc
    11101 gggcctgtga gcccggcttc agcgcccccg gaggcgaacc gagccgcaaa atggggggat
    11161 gagcgaacga cttgtggtca tcggtgggga cgcggcgggg atgtccgccg cgtcgcaggc
    11221 gcggaggctc agggaacccg gggagctgga gatcgtcgcc ttcgagcggg gccgtttctc
    11281 ctcgtactcg gcgtgcggca tcccgtactg ggtcggcggc gacgtctcct cgcgcgacga
    11341 gctgatcgcg cgctcccccg aggaacaccg ggagcgcgcc atcgatctgc ggatgcggac
    11401 ggaggtgacg gagatcgacg tggccggtca gcgggtccgc gcacgcgacc tggagagcgg
    11461 tgcggaggcc tggacgggct tc
//
