LOCUS       NZ_JAIHBQ010000001     22631 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1027789
            Orig. end                         :: 1050420
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22631
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="6"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22631
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22631
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12631](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12631
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(15..1850)
                     /locus_tag="K4902_RS04470"
                     /old_locus_tag="K4902_04470"
     CDS             complement(15..1850)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823439.1"
                     /locus_tag="K4902_RS04470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04470"
                     /product="thiamine pyrophosphate-requiring protein"
                     /protein_id="WP_221744187.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.4e-42, bitscore:
                     143.9, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.6e-29, bitscore:
                     100.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTKVSDHVLHRLREWGVEHVFAYAGDGINGLLAAWGRADNKPK
                     FVQARHEEMAALQAVGYAKFSGRVGVCAATSGPGAIHLLNGLYDAKLDHVPVVALVGQT
                     NRSAMGGSYQQEVDLHSLYKDVASDFCETATVPEQLPNLIDRAMRTAYAKRTVTAIILP
                     ADVQDLDYSPPAHAFKMVPSSLGMSRYAPVPADEDVARAAEVLNAGERVAVLIGQGAAG
                     ARAEVERLADVLGAGVAKALLGKDALPDDLPYVTGAIGLLGTRPSYELMRECDTLLVIG
                     SSFPYSQFLPEPDQARAVQIDIDPHMIGLRYPFEVNLVGDARETLQRLLPRLHRKTDRA
                     WREKVEENVARWWEVMQRRAAVDADPLNPEYVVHALDGRLPDNAILTADSGSAANWYAR
                     HLRLRGAMRGSLSGTLATMGPGVPYAIGAKFAHPDRPAIALVGDGAMQMNGMMELVTAA
                     KYRHEWSDPRLVVAVLNNGDLNQVTWEMRAMSGAPQFEESQHLPDLPYADIARSIGLDG
                     VRVEKPKHVEAAWDRALAADRPFVIDFRTDPAVPPIPPHATLDQIEAAATAILHGDSDT
                     GSVLKQGLKAKVQEFLPGTRHRHDRPGAGRDDSAR"
     misc_feature    1820..1834
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     gene            complement(1936..2262)
                     /locus_tag="K4902_RS04475"
                     /old_locus_tag="K4902_04475"
     CDS             complement(1936..2262)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970760.1"
                     /locus_tag="K4902_RS04475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04475"
                     /product="plasmid stabilization protein"
                     /protein_id="WP_221744195.1"
                     /transl_table=11
                     /translation="MPAGSNAKRERQYEHIKESAEKRGSSEKRAKEIAARTVNKERARS
                     GESATASKTSTGDRKSASQRGGERSHSGSQGPTKDQLYAEAKKRGVEGRSSMNKQELKK
                     ALGR"
     misc_feature    2419..2434
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.68"
                     /tool="antismash"
     gene            2493..4619
                     /locus_tag="K4902_RS04480"
                     /old_locus_tag="K4902_04480"
     CDS             2493..4619
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151764.1"
                     /locus_tag="K4902_RS04480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04480"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_260461815.1"
                     /transl_table=11
                     /translation="MGDDGVGSADWVSLERVLSGTVQRTGAVAAGVYLLSPDEPVLALT
                     TVCGLPAKTLAPWWRVAVSAAGPLSEAVREDRLVWVGRQEDMARLYPNAAAGLPYQFAL
                     AFAPLNGTRRWGALALVWSDSHPPSLTRRERGHVLSSANRITRVLDGAPAVWSVPEEPR
                     AVPLRRSGPDPTQTGLAADDLLQRLPVGALGFDLQGRITYLNDAAARMLGRSADSLLGT
                     LPWQAVPWLDAPVHEDHYRAAVFGRESVAYTAPGPSDRWFDIRLYPGDSGISAFISPSL
                     RERTPDAPPPRVTPAPYTPPRGAGTGRIHQLMHLAAALSQTVTVADVIDAVADQILPAF
                     GAQGMVVSAADAGRLRIIGHRGYDPRTIARLDGLPLNTDITPVGRVLDSGVPAFYAAPA
                     EMTVAHPQAPALSGKQAWAFLPLLVSDRRVGCCILSYDRPRRFGAGDRAVLVSLAGLIA
                     QAMDRALLYDAKHDLAHGLQQALLPVALPPVPGLDVTARYLPATHGIDIGGDFYDLIRL
                     GDASAAAVIGDVQGHNIKAAALMGQVRTAVHATAGAAPGDVLARTNRVLTDLETELFVS
                     CVYLHIDLAERRLHLASAGHPPPLLHRTGPAPHTVALEVEPGPLLGIQPCTAADYPVTT
                     TDLPPGSLLALYTDGLVETPDTDLTHSIAALTRRLTRDAGRPLDELAEHLLHHHAALRH
                     TRTDDTALLLLRSR"
     gene            complement(4638..4874)
                     /locus_tag="K4902_RS04485"
                     /old_locus_tag="K4902_04485"
     CDS             complement(4638..4874)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4902_RS04485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K4902_04485"
                     /product="hypothetical protein"
                     /protein_id="WP_198942268.1"
                     /transl_table=11
                     /translation="MVGGALAHHQYHRVSHPPVEHLDDILRNGALFHDRWGEWPMKGRL
                     LDFARLGLVSHDARTGSWHRRDSAAARTSDRPG"
     gene            complement(<4934..5035)
                     /locus_tag="K4902_RS36665"
                     /pseudo=""
     CDS             complement(<4934..5035)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014734.5"
                     /locus_tag="K4902_RS36665"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 2 protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLTGGDHRLFWSLSFAVTAATWRRIGGFCEDYTG"
     gene            complement(5029..5199)
                     /locus_tag="K4902_RS36075"
     CDS             complement(5029..5199)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016027.5"
                     /locus_tag="K4902_RS36075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_241845386.1"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 6.3e-08,
                     bitscore: 31.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVTHAGQNAVAECAAARVPAVVVPQSRPHGEQHATAHALAEGGL
                     ATVRDHWPERC"
     misc_feature    5460..5475
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.9"
                     /tool="antismash"
     gene            5470..6561
                     /locus_tag="K4902_RS04495"
                     /old_locus_tag="K4902_04495"
     CDS             5470..6561
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237482.1"
                     /locus_tag="K4902_RS04495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04495"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_221744197.1"
                     /transl_table=11
                     /translation="MIESGRPRLRRSHGNGRLVRLSPVILTVVIAGLAYATPPEMAFSR
                     LLPAAPALAAAMWPVLPTVLLGTVCLLLMIGLSLVFPDLGAWWTCGGIVAVTVAAAYGS
                     HVRLQRERTLFQVRLVADAAQQVVLRPLPHRFRNVEIESLYLAAAAEARIGGDFYEVVD
                     TPYGVRLLIGDVRGKGLPAVGAAAAIVNAFREAAHGESSMADVARRLDASCARHNAAHP
                     PEAPMERFATALLVEIPHRGSRITIVNCGHPPPLIHGPRTVRVLAPSAPSPLLSLAELL
                     GDQYRADAFDLGPGELLLLYTDGIAETRARDGAFFPLAEWMRRQPPTPPRDLLTALHHD
                     LLRHSRGSLDDDIAALAVRLHTP"
     gene            complement(6622..9018)
                     /locus_tag="K4902_RS04500"
                     /old_locus_tag="K4902_04500"
     CDS             complement(6622..9018)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309966.1"
                     /locus_tag="K4902_RS04500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04500"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_221744199.1"
                     /transl_table=11
                     /translation="MEGLPFTPPVGADEGGHLGPPPAAFALLAADGVLVGWSREAEALL
                     GYTASQVRGRRAVDLIATPHASRDGPDEPRWDRRPRLGGARSAVVDVRHRGGGTVRVAV
                     TLHPLTPAPDAASSGQAPHAVLMATELERLRWWETRQAMLEGLVTQSPVTLTIYGPGAR
                     LLWANASSVRELGGDLTTSLGRSMTELFPGDVLTAQHLAPPEDLFRQILETGEPVIDVH
                     FRGRAPADPRREHVWSSSYFRLVDGRGEPVGVCEQSIDVTDHYRAQQRLALLAEAGARI
                     GSTLDPSGTAAELAKIAVPQYADAVSVDVAAGVLDGEEPKPVTAWDLVRVADSDGDPSR
                     VGERVAYAAGSAQAESLAQGRPTKDAVVPQTRLYVPLIVRGTPLGLVTFVRGDDAEPFD
                     DGDRAVAEELASRTAVCIDNARRYRREHTAAFMLQRSLLPRSLPELSAVEAASRYLPAD
                     SHLGAGGDWFDVIPLSGARVGLVVGDVPGHGLGAAATMGRLRAMVRTLAELDLAPDELL
                     ARLNDQVGKDPSDQGGTGADGSGAVGATCLYGIYDPASRTSTWAAAGHQPPAVVQPHGP
                     VRFLRLPPGLPLGVGRLPYEGAEEELAEGSLVVLFTDGLVEARGKGADVGLDRLATVLG
                     EQRGSSPDRLCAQTVAALASDEVRDDATLLVVRTRALGTRQVATWELPPDPALVARART
                     MAAEQLGRWGLDDLVFTTEVVVSELVTNAIRHAFGRIGLRLIRDRSLICEVSDSQHTSP
                     HARYAGSDEEGGRGLFMVAQLTEHWGTRYTPAGKTIWAEQALPVA"
     gene            complement(9095..9526)
                     /locus_tag="K4902_RS04505"
                     /old_locus_tag="K4902_04505"
     CDS             complement(9095..9526)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038597.1"
                     /locus_tag="K4902_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04505"
                     /product="subtilase-type protease inhibitor"
                     /protein_id="WP_073813171.1"
                     /transl_table=11
                     /translation="MLRGFVAASTSALLLLTGAAGVAEARTDSLYAPSALVLSVSKGAD
                     ASAATVLRAVTLSCAPTAAGTHPAPEAACAELKATSPGGAFDGLLASPNPDRMCPQHFD
                     PVTVSVDGVWEGARTSWTHTFANTCTMGATLNGGAAFAF"
     misc_feature    complement(9566..9583)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.82"
                     /tool="antismash"
     misc_feature    9568..9582
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.62"
                     /tool="antismash"
     misc_feature    9586..9602
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 19.95"
                     /tool="antismash"
     misc_feature    9785..9800
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    9803..9821
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
     misc_feature    complement(9961..9973)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(9961..9976)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            10001..12631
                     /gene="lanKC"
                     /locus_tag="K4902_RS04510"
                     /old_locus_tag="K4902_04510"
     CDS             10001..12631
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037663.1"
                     /locus_tag="K4902_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04510"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_221744201.1"
                     /sec_met_domain="micKC (E-value: 1.1e-234, bitscore: 780.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.1e-10, bitscore: 39.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.9e-10, bitscore:
                     37.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVFCDADRHFYDAPHRLVFAGSGSGSLYRAATLPVPEGWT
                     SHRTGDWLALRPLDHTLPSQGWKIHVSAGLDNAEAVLATVRAYCLEQVVAFKFVPSRYL
                     LHQRNAKYADRSASGKFITVYPADDRQCERVATDLAGLLDGEPGPYILSDLRWGRGPLH
                     LRYGSFTLRHCYDEHGELRPALEDGSGTLVPDRRGPVFHLPEWVTPPAFVRPHLAARAA
                     VTVADMPYEIEKALHFSNGGGVYEARHRRTGRRVVLKEARPYAGLAADGADAVTRLHRE
                     RDALRQLSGLPCTPEVLDSFTIGEHHFLALEFVEGKPLNTFFARRHPLMEAEPSAERIA
                     EYTEWALRIHGLVERAVAEVHARGIVFNDLHLFNIMVSEDESSVTLLDFEAAKPAAEGG
                     RQTVANPAFVAPADRRGFDVDRYALACLRIALFIPLTSLLAVDRAKAAHLAEAAAARFP
                     LPPGFLDEAVREILRDPAGDPPGRRGRAPERPSGRTRFLPVEPGDWPAARDSLVRAVMA
                     SATPERDDRFFPGDIAQFATAGGGMTVGHGTAGVLYALRESGGPRCPEAEDGLLRHAKR
                     PDSGTPLGFYDGLTGVAWTLDRLGHAAAALDLAALVQEQDFDALAPDLHGGTAGIGLAL
                     DALATTTGESGLHAAALRCAELSARPLGASARTAGAASGKVRTGLLHGGAGRALLFIRL
                     YERTRDSALLDLAADALHDDLSRCVRGASGTLQVDEGWRTMPYLGAGSVGIGMVIDDYL
                     LHRHDDALDRARHDIVRAAQATFYAQPGLFRGVAGMVLHLARTNAGGPGTTPEDVRRQV
                     GCLTWHAMTYQGHLAFPGEQMMRLSMDLSTGTAGVLLALAAALGDRPAHLPFLPPLPRP
                     HEPAP"
     misc_feature    10484..10486
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12675..12803
                     /locus_tag="K4902_RS04515"
                     /old_locus_tag="K4902_04515"
     CDS             12675..12803
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="K4902_RS04515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04515"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_015037662.1"
                     /transl_table=11
                     /translation="MNLFDLQSLETPKDEAIGDVETGSRASLLLCGDSSLSVTTCN"
     CDS_motif       12675..12737
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLFDLQSLETPKDEAIGDVE"
                     /locus_tag="K4902_RS04515_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12738..12803
                     /prepeptide="core"
                     /locus_tag="K4902_RS04515_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="22.80"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSLETPKDEAIGDVE"
                     /leader_location="[12674:12737](+)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     gene            12978..14744
                     /locus_tag="K4902_RS04520"
                     /old_locus_tag="K4902_04520"
     CDS             12978..14744
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="K4902_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04520"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_260461816.1"
                     /transl_table=11
                     /translation="MAWPTGSDRLFAGAVRHTAGLTAALLLCSVVGAACSLAVPALAGR
                     TLDMLLRHRPGAETWLVWTAVLLVAEILNETGAVLLTQLSNARATAWYRLRALGGLLGT
                     APHRAAHLSGGDVAARLCVNATDSGTAPAALATSVSSVLVPIGALVALALIHPWTAVVF
                     AAGLPLLLLLLRAFATQSSDSVARYQRAQASIATRLAEALGGARTIAAADTARREEERV
                     LAPLPELTRHGTRMWLVHGRAVARSGVLLPLLTTAVVAVAGAGLAAGDVSVGELLAASR
                     YAALAAGIGGIAAPLGTLVRARAAARRTTELGRLTPMSYGSAVLPADGPGALELRGVRV
                     VRGGVPLIADVTLALGGGSTVAVVGRSGAGKSTLASVAGRLTDPDAGQVLLDGVDLADL
                     SSAELRGAIAYAFARPVFDGGATVTVGAAVAAGVGPRHGPATAERVREAAAAACADTFV
                     RLLPLGYGTPVDEAPMSGGEAQRLGLARAFIGRGRLMILDDATSSLDTATERQVEVALA
                     ASPRPCTRLIVAHRVSTAARADRVVWMEAGRVRGCGPHHLLWEDPDYRAVFLAETSRPG
                     AMAPAAGAGAGE"
     misc_feature    complement(12984..12998)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            14900..16585
                     /locus_tag="K4902_RS04525"
                     /old_locus_tag="K4902_04525"
     CDS             14900..16585
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962286.1"
                     /locus_tag="K4902_RS04525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04525"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_311775862.1"
                     /transl_table=11
                     /translation="MLVRLAAWSLAESAQTFLGGYCVARSLDDGFMRGSPRTGLLWLVG
                     AAVAIVLGAPVVRGVFAQLPHLTETLRDHLVRESVVRALRAATTAGGGADATAVSRLTS
                     QTEIARDSFAGLVLATRSFVFVAAGALVGLLSLAPQFLLVVLPPLALGLAVFTASLRPM
                     ARAQHRYLDADEVVGRRAEITRDALRDTVALGAQEATAAVNRRAVDEAAAAQRALARWA
                     SVRTLSVATAGQLPVFLLLAATPWLLRQGVTAGAVVGALTYVLQSLLPALHTLMTVLGA
                     AGARLYVILDRLTRPLPAAPAPPSAPAPGPARTGRTTAALELHRVRAAYGPGARPVLDD
                     LELTVEQGEHLAVVGPSGIGKSTLLHVAAGLLTPEQGDVRLLGRAAGACGPPELAALRV
                     LLPQEAYVFTGTLRENLLYLRPGTGRPETDRSAVDRAVDALALGPLVDRVGGLDRTLAP
                     DALSLGERQSIALGRAYLAPAPLLLLDEATCHLDPVAEATAEHALSARPGTLVVVAHRL
                     SSALRADRILVVDGTRAQHGTHAELLVRSALYRDLTGHWGGAGG"
     gene            complement(16621..17235)
                     /locus_tag="K4902_RS04530"
                     /old_locus_tag="K4902_04530"
     CDS             complement(16621..17235)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037659.1"
                     /locus_tag="K4902_RS04530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04530"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_073813166.1"
                     /transl_table=11
                     /translation="MIRVTVVYEERLLRSALEELLRSNGVQVVSSLPRWPHGPAAERSE
                     TDVYVADAECLPPTAVAPATASVPPRGAGTAGRSALLALVPGQRPGVLRRAHAAGAVGF
                     VDKDSPKGRLLEAVHRLAKGERFIDDTLALGFLQAAEMPLTRRELSVLSLAANGAPIAE
                     IAATLFLSKGTVRNYMASVIRKVGARNRVDAIRIAQGAGWT"
     misc_feature    complement(16894..16896)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17556..19562
                     /locus_tag="K4902_RS04535"
                     /old_locus_tag="K4902_04535"
     CDS             17556..19562
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122746.1"
                     /locus_tag="K4902_RS04535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04535"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_221744204.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 7.3e-13, bitscore:
                     47.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.3e-18, bitscore:
                     64.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-14, bitscore:
                     53.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATDNASPATTGYVQPAIDVRRLGAVLDGEYAGIRGLVRTNLARY
                     ASVLEEADDLGVDAFRERVREVVVEMAATGQTGMGFPEAYGGGGDVGASIAAFETLAFG
                     DLSVLVKVGVQFGLFGGAILHLGTERHHEAYLPGLITGELMGCFAMTETGHGSNVQALG
                     TVARYDAARQEFVITTQGDQARKDYIGNAARHAELAVVFARLEVDGRSEGVHAFVVPLR
                     VAGEVAPGVRIEDDGRKMGLNGVDNGRIWFDGVRVPREALLNRFADVSPDGVYESSIAN
                     PDRRFFTMLGTLVQGRVSVAGAGIGVAKVALAVATKYAVRRRQFAASADAEEQVLLDYG
                     LHQRRLLPLIARTYALHFAQDVVRSHLHEVFSGAEDDAPARRRLESRAAGLKALGTWHA
                     TRVVQECREACGGAGYLAVNRFAALKSDSDVFTTFEGDNHVLLQLVAKGLLTDHASEFE
                     DLDQLGVVRYVTGLAVETVIERTSAHKLLERVRDLLPGGDEWDREAGLLDPEYQLAMLR
                     FREEHMLAGVARRIKRGTDQKRAPGAVFSQVQDHVIALARAHVERLVAEAFVDKVRAMP
                     EGGEREALALLCDLFALSTIEADRAWFMEHGRLTVQRSKAITREVNDLCRKVRPLAVDL
                     VDAWGIPPEMLRAPELVGGDPEPTAPSPAASAR"
     gene            complement(19624..20277)
                     /locus_tag="K4902_RS04540"
                     /old_locus_tag="K4902_04540"
     CDS             complement(19624..20277)
                     /EC_number="3.1.21.10"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017663.5"
                     /locus_tag="K4902_RS04540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04540"
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="WP_221744206.1"
                     /transl_table=11
                     /translation="MSSSVVTEDDFEVREFRGHGRVDILSAVDPVSLQAGPVRKAGFKD
                     ALASAVRTATTGVFTHDVEVSLVWYIEESRRYQTHLVADIDNVLKPILDAVTGLDGIMI
                     DDNQVQSIRASWMTPGPRAGFELQFTALRADDYLSREGLSFVEFGADRCYLLPRAERSV
                     QAVIVRAYREALAGHRHLLDTGIPEDVARSVLPSVRPFPRARLGQFEVRRQEDF"
     gene            20482..20934
                     /locus_tag="K4902_RS04545"
                     /old_locus_tag="K4902_04545"
     CDS             20482..20934
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327105.1"
                     /locus_tag="K4902_RS04545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04545"
                     /product="phospholipase"
                     /protein_id="WP_073813158.1"
                     /transl_table=11
                     /translation="MHQRLAVGLSASALALFTTVATATVATAAPADKPQVLSSWTQTSA
                     SSYNLWAAARANQGAWSAYGFDWSTDYCSTSPDNPLGFPFSASCARHDFGYRNYKAAGT
                     FSANKARLDSALYEDLKRVCLNYSGATKTTCNSTAWTYYQAVKAFG"
     gene            complement(21049..21729)
                     /locus_tag="K4902_RS04550"
                     /old_locus_tag="K4902_04550"
     CDS             complement(21049..21729)
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071839.1"
                     /locus_tag="K4902_RS04550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04550"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_260461817.1"
                     /transl_table=11
                     /translation="MTENIAWATPATDIFPTADGYVGDPAVRAEWDNRYADRQQLWSGR
                     PNGALVAEVAGLTPGRVLDVGCGEGADAVWLARGGWDVTALEVSGVALERAAGHARDAG
                     VDIRWVHATLTEAALPPASYDLVSAQYPVLLRTPDRVAEHALLSAVAVGGVLLLVHHAG
                     MESQQVNETGFDPADYVWPSMVVPLLGDDWAVEVDEQRPRVSPEGGAGAHHTDDVVLRA
                     RRLR"
     misc_feature    complement(21701..21721)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    complement(21776..21790)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.27"
                     /tool="antismash"
     gene            complement(21896..22177)
                     /locus_tag="K4902_RS36670"
                     /old_locus_tag="K4902_04555"
     CDS             complement(21896..22177)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240756.1"
                     /locus_tag="K4902_RS36670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_04555"
                     /product="hypothetical protein"
                     /protein_id="WP_073813155.1"
                     /transl_table=11
                     /translation="MLISHAVSDQVLTVTLHRDLDVTNRAAGALQIQALVQAHRPTRVV
                     IAVPSADPTPATLSTLTRAHRMCTSLGIPLALSGASARTRRLLGVTGE"
     misc_feature    complement(22149..22164)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
     misc_feature    complement(22479..22492)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.82"
                     /tool="antismash"
ORIGIN
        1 cgggtcgttc actttcaccg ggcgctgtcg tcccgtccgg cgccgggacg gtcgtggcgg
       61 tgacgggtgc cgggaaggaa ctcctggacc ttggccttga ggccctgctt gaggacggag
      121 ccggtgtcgc tgtcgccgtg caggatcgcg gtggcggccg cctcgatctg gtcgagggtc
      181 gcgtgcgggg ggatcggcgg cacggcggga tcggtgcgga agtcgatgac gaagggacga
      241 tcggcggcga gcgcccggtc ccaggcggcc tcgacgtgct tgggcttctc gacccgcacg
      301 ccgtcgagcc cgatgctccg ggcgatgtcg gcgtagggca ggtcggggag gtgctgggac
      361 tcctcgaact gcggcgcgcc cgacatggcg cgcatctccc aggtgacctg gttcaggtca
      421 ccgttgttga ggacggccac gaccaggcgc gggtcggacc actcgtgccg gtacttcgcg
      481 gccgtgacca gctccatcat gccgttcatc tgcatcgcgc cgtcgccgac gagagcgatc
      541 gcgggccggt cggggtgggc gaacttcgcg ccgatcgcgt acggcacgcc gggccccatg
      601 gtggccagcg tcccggacag cgaaccgcgc atggcaccgc gcagccgcag gtgccgggcg
      661 taccagttgg cggctgagcc ggagtcggcg gtcaggatcg cgttgtcggg cagcctgccg
      721 tccagggcgt ggaccacgta ctcgggattg agcgggtcgg cgtccacggc ggcccggcgc
      781 tgcatgacct cccaccagcg cgcgacgttc tcctcgacct tctcccgcca ggcgcggtcg
      841 gtcttgcggt gcaggcgcgg cagcagccgc tggagggtct cgcgcgcgtc accgacgagg
      901 ttcacctcga acgggtagcg cagcccgatc atgtgcggat cgatgtcgat ctgcaccgcc
      961 cgcgcctggt ccggttcggg caggaactgc gagtacggga agctggatcc gatcacgagc
     1021 agggtgtcgc actcccgcat cagctcgtac gacggacggg tgccgagcag gccgatggcg
     1081 ccggtcacgt acggcaggtc gtcgggcagc gcgtccttgc cgagcagcgc cttcgccacc
     1141 cccgccccca ggacgtccgc cagccgctcg acctcggcgc gtgcgccggc ggcaccctga
     1201 ccgatgagca cggcgaccct ctcgccggcg ttcaggacct ccgccgcccg cgcgacgtcc
     1261 tcgtccgccg gcaccggggc gtagcggctc atgcccaggc tggagggcac catcttgaac
     1321 gcgtgcgccg gcgggctgta gtccaggtcc tggacgtcgg ccggaaggat gatcgccgtc
     1381 acggtgcgct tggcgtacgc cgtgcgcatc gcccggtcga tcaggttcgg cagttgctcg
     1441 gggaccgtcg cggtctcgca gaagtcggag gcgacgtcct tgtacaggct gtgcaggtcc
     1501 acctcctgct ggtacgagcc gcccatcgcg ctgcgattgg tctgacccac cagcgccacg
     1561 accgggacgt ggtccagctt cgcgtcgtac aggccgttga gcaggtggat ggctcccggg
     1621 ccggaggtcg ccgcgcagac gcccaccctg ccggagaact tggcgtatcc gaccgcctgg
     1681 agagcggcca tctcctcatg gcgcgcctgg acgaacttcg gcttgttgtc cgcacgcccc
     1741 cacgccgcga gcaggccgtt gatgccgtcg ccggcgtacg cgaagacatg ctccaccccc
     1801 cactcccgca gccggtggag gacatggtcg gacaccttgg tgctggtcat gggttccgtt
     1861 cctgttctgg gcggctgacg cccgcgcgtc cggacggccc gcctcgcccg cgtggtctct
     1921 cccgagccgg tcggctcagc ggcccagggc cttcttgagt tcctgcttgt tcatggacga
     1981 acggccctcg accccccgct tcttcgcctc cgcgtagagc tggtccttgg tcggcccctg
     2041 agaaccgctg tgcgagcgct cgccgccgcg ctgcgaagcg gacttcctgt cgcccgtgga
     2101 ggtcttgctc gcggtcgcgg actcgccgga gcgggcccgc tccttgttca cggtccgcgc
     2161 ggcgatctcc ttcgcccgct tctcggagct gccgcgcttc tcggcgctct ccttgatgtg
     2221 ctcgtactgc cgctcgcgct tcgcgttcga tcctgccggc atgacacttc ctcttctccg
     2281 accgccgcgg cccgtccggc cgcgtgtgcc ttccggttac ccggtggccg gtgcctcact
     2341 cggcaccggt cccatcccac gcgaagttcc cggagcgcgc gatcgggcag tgaccgaacg
     2401 ggagaccggc gacgccgctc gcatgtccgg tcggtgtgcc cgcgccgccg cgtgaccgga
     2461 ctttcctctc cggcgggctt agtgttctgt acgtgggtga tgacggcgtc gggtctgccg
     2521 actgggtgtc cctggagcgg gtgctcagcg gtacggtgca gcgcacggga gcggtggcgg
     2581 cgggcgtgta cctgctgtcc ccggacgagc cggtgctggc cctgacgacg gtgtgcgggc
     2641 tgccggcgaa gacgctggca ccgtggtgga gggtggccgt gtcggctgcc ggtccgttgt
     2701 ccgaggcggt gcgggaggac cgtctcgtct gggtggggcg gcaggaggac atggcccgtc
     2761 tgtatccgaa cgccgcggcc gggctgccct accagttcgc gctggccttc gcgcccttga
     2821 acggaacccg ccggtggggg gccctggcgc tggtgtggtc cgacagccac ccgccctcgt
     2881 tgacccgtcg tgagcgcggg cacgtcctgt ccagcgccaa ccggatcacc cgggtactgg
     2941 acggagcacc cgccgtctgg agcgttcccg aggaaccgcg tgccgtaccg ctgcggcggt
     3001 ccggcccgga cccgacgcag accggcctgg ccgccgacga cctcttgcag cgactgcccg
     3061 tcggcgccct cggcttcgac ctgcaggggc gcatcaccta tctcaacgac gccgccgccc
     3121 ggatgctcgg ccgcagtgcc gacagcctcc tcggcaccct gccgtggcag gccgtgccct
     3181 ggctcgacgc cccggtccac gaggaccact accgcgccgc cgtcttcggc cgcgagtccg
     3241 tcgcctacac cgccccgggt ccgtccgacc gctggttcga catccggctc tatcccggtg
     3301 acagcggtat cagcgccttc atctccccca gcctccgcga gcggacgccc gacgccccgc
     3361 cgccccgtgt caccccggct ccgtacactc cgccccgcgg cgccggtacg ggacggatcc
     3421 accagctgat gcacctggcg gccgccctga gccagaccgt caccgtggcc gatgtcatcg
     3481 acgcggtggc cgatcagatc ctgcccgctt tcggagccca gggcatggtc gtctccgccg
     3541 ccgacgccgg ccgtctgagg atcatcgggc accgcggcta cgacccgcgc accatcgccc
     3601 gcctggacgg cctgccgctg aacacggaca tcaccccggt cggccgcgtc ctggacagcg
     3661 gggtcccggc cttctacgcc gcccccgcag agatgaccgt cgcccacccg caggcgcccg
     3721 cgctcagcgg caaacaggcc tgggcgttcc tgcccctgct cgtctccgac cgccgcgtcg
     3781 gctgctgcat cctgtcctac gaccgtcccc gccgtttcgg cgcgggtgac cgcgccgtcc
     3841 tggtgtccct cgccggcctc atcgcccagg ccatggaccg cgccctgctg tacgacgcca
     3901 agcacgacct cgcccacgga ctgcagcagg cactccttcc cgtggccctg cctcccgtcc
     3961 ccggcctcga cgtcaccgcc cgctacctgc ccgcgaccca cggcatcgac atcggcggtg
     4021 acttctacga cctgatccgc ctcggcgacg cgtcggccgc cgccgtcatc ggagacgtgc
     4081 aaggccacaa catcaaggcc gcggccctga tggggcaggt ccgcaccgcc gtccacgcca
     4141 ccgccggggc ggcgcccggc gacgtcctgg cccgcaccaa ccgcgtcctg accgacctcg
     4201 agaccgagct gttcgtctcc tgcgtgtacc tccacatcga cctcgcggaa cgacgtctcc
     4261 acctggccag cgcgggacac ccgcccccgc tgctccaccg caccggcccc gcaccgcaca
     4321 ccgtcgcgct cgaagtggag ccaggccccc tcctcggcat ccagccgtgc accgcggccg
     4381 actaccccgt cacgaccacc gacctccccc cgggatctct cctcgccctc tacaccgacg
     4441 gcctcgtgga gacccccgac accgacctca cccactccat cgccgccctc acccggcggc
     4501 tcacccggga cgccgggcgg ccgctcgacg aactggccga gcacctcctc caccaccacg
     4561 cggccctccg gcacacccgc acggacgaca ccgccctgct tctgttgcgc agccgctgat
     4621 gcggagggcc gggggcctca gccgggccgg tcggaggtcc gggcggccgc ggaatcccgt
     4681 cggtgccagg agccggtccg ggcgtcgtgg gagaccagtc cgaggcgggc gaagtcgagc
     4741 agccggccct tcatgggcca ttcgccccac cggtcgtgga acagggcgcc gttgcggagg
     4801 atgtcgtcca ggtgctcgac gggcgggtgg ctgacgcggt ggtactggtg gtgggcgagg
     4861 gccccgccca ccaccacagg tccacgcccc gggcggcggc ggtcctggcg aagtcggtgt
     4921 cctcgccgcc gtatccggtg tagtcctcgc agaagccgcc gatccgccgc cacgtggccg
     4981 cggtcacggc gaacgacaga gaccagaaca gccggtggtc accgccggtc agcaccgttc
     5041 gggccagtgg tcccgtacgg tggccagtcc gccctccgcc aaggcgtggg cggtggcatg
     5101 ctgttcgccg tgcggccggg actgcggcac gaccacggcg gggacacggg cggcggcaca
     5161 ctcggccacg gcgttctgcc cggcgtgggt gaccaccacg tcggcccggc acaacagcgg
     5221 ccaggggtcg tcggtccagc ccccgggccg cccagttcgg ctccgcaggc ggcgcaggtg
     5281 ccctgggcac ggcttgcgtc gcgcggaccg ccgcgagcgc accgctcggg ccgcgactcg
     5341 atcgtcgtac aaccgccccg tccccgcctc ctgtgaggcc gaacggcgga acaccggccc
     5401 ggccccggcc ggggcggcgg gtgtcccgcc gcgtcgctga gcgggcaccg cgcggataat
     5461 ctgggattca tgatcgagtc cggacggccg cggctccgtc gaagtcacgg caacggcagg
     5521 ctcgtgcggc tgtcgccggt cattctgacc gtcgtgatcg ccggcctggc ctacgccacc
     5581 ccgccggaga tggccttcag ccgcctcctg cccgcggcgc cggctctggc cgccgccatg
     5641 tggccggtcc tcccgaccgt cctgctcggg accgtctgcc tccttctgat gatcggcctc
     5701 agcctcgtct tccccgatct gggggcgtgg tggacgtgcg gggggatcgt cgcggtcacc
     5761 gtggccgccg cgtacggaag ccacgtccgg ctgcagcggg aacgcaccct ctttcaggtg
     5821 cggctcgtcg ccgacgccgc ccagcaggtg gtgctgcggc ccctgccgca ccgtttccgc
     5881 aacgtcgaga tcgaatcgct gtacctggcg gccgccgccg aggcccgcat cggaggggac
     5941 ttctacgagg tggtcgacac gccgtacgga gtacggctgc tcatcggcga cgtgcggggc
     6001 aagggcctgc cggcggtggg agcggcggcg gcgatcgtca acgccttccg ggaggcggca
     6061 cacggcgagt cctccatggc cgacgtcgcc cgcaggctcg acgccagctg cgcccggcac
     6121 aacgccgccc atccacccga ggcaccgatg gaacgcttcg ccaccgcgct gctcgtcgag
     6181 atcccgcatc gaggcagccg catcaccatc gtcaactgcg gacacccccc accgctgatc
     6241 cacggcccga ggaccgtgcg cgtcctcgcg ccgtccgccc cgtcgcccct gctcagcctc
     6301 gcggagctgc tcggtgacca gtaccgcgcg gacgccttcg acctcggtcc cggcgagctc
     6361 ctcctcctct acacggacgg gatcgccgaa acccgcgccc gggacggtgc gttcttcccg
     6421 ctggcggaat ggatgcgcag gcagcctccc acgcctcccc gtgatctgct cacggccctg
     6481 caccacgacc tcctccgtca cagcagaggc agcctcgacg acgacatcgc cgccttggcg
     6541 gtacgcctgc acacgccctg agccatggcc ggggcgagcg gaaccgagac ccgagtcacc
     6601 cgcgggggcg gcgcgcggcc ctcacgccac gggcagggcc tgttccgccc agatcgtctt
     6661 ccctgccggc gtgtaccgcg tcccccagtg ctcggtgagc tgagcgacca tgaacagtcc
     6721 acgtccgccc tcctcgtcgc tgccggcgta ccgggcatgc ggtgaggtgt gctgcgagtc
     6781 ggagacctca cagatgagag aacggtcccg gatcagccgc agaccgatcc ggccgaaggc
     6841 gtgacggatc gcgttggtga ccagttcgct gaccaccacc tccgtggtga agaccagatc
     6901 gtccagtccc caccgcccca gctgctccgc ggccatcgtc cgtgcgcgtg cgacgagcgc
     6961 ggggtccggg ggcagctccc aggtcgccac ctgacgtgtc cccagcgcac gggtgcgcac
     7021 gacgaggagc gtcgcgtcgt cccgcacctc gtccgatgcc agcgcggcga cggtctgggc
     7081 gcacaatcgg tcgggcgacg atccccgctg ctcgccgagt acggtcgcca accggtccag
     7141 gcccacgtcg gcgcccttcc cccgggcctc cacgaggccg tcggtgaaca ggacgaccag
     7201 gctcccctcg gcgagctcct cttccgcgcc ctcgtaggga agccgtccca cacccagcgg
     7261 aagccccggt ggcagacgaa ggaaccggac ggggccgtgc ggttggacca ccgccggcgg
     7321 ctggtgtccg gcggccgccc aggtgctcgt ccgggaggcc ggatcgtaga tcccgtagag
     7381 gcacgtcgct ccgacggcgc cgctgccgtc cgcgcccgtc ccgccctggt ccgacgggtc
     7441 cttgccgacc tgatcgttca gccgggccag gagttcgtcg ggcgcgaggt ccagctcggc
     7501 cagggtccgc accatcgcgc gcaggcgccc catggtggca gcggccccga gtccgtggcc
     7561 ggggacgtcc cccacgacga gtccgacacg tgcccctgag agcggtatga cgtcgaacca
     7621 gtctccgccg gcgccgaggt ggctgtcggc cggcaggtag cgactcgccg cctcgaccgc
     7681 gctcagctcg ggcagcgatc gtggcagcag gctgcgctgg agcatgaacg cggcggtgtg
     7741 ctcccggcgg taccgccggg cgttgtcgat gcacacggcg gtccgcgacg ccagctcctc
     7801 ggccactgcc cgatcgccgt cgtcgaaggg ttccgcgtcg tcgccccgca cgaaggtgac
     7861 gaggcccaga ggcgtccccc gcacgatcag cgggacatac agccttgtct gcggaaccac
     7921 ggcgtccttg gtcgggcggc cctgggccag gctctcggcc tgcgccgatc cggcggcgta
     7981 cgcgacccgc tcgcccaccc gggagggatc cccgtcggaa tccgccacgc gtacgaggtc
     8041 ccatgccgtg acgggcttcg gttcctctcc gtcgagcact cctgccgcca cgtcgacgga
     8101 cacggcgtcg gcgtactgcg gtacggcgat cttggcgagc tccgccgccg ttccggacgg
     8161 atcgagtgtc gacccgatcc gcgcgccggc ctccgcgagg agggcgaggc gctgctgcgc
     8221 acggtagtgg tcggtgacgt cgatggactg ctcgcacacg cccaccggct ctccccggcc
     8281 gtccaccaac cggaagtagg acgaggacca gacgtgctca cgccgggggt cggccggagc
     8341 gcgccctcgg aagtgcacgt cgatgaccgg ctcaccggtc tccaggatct gtcggaagag
     8401 gtcctccggc ggcgccaggt gctgggcggt gaggacgtca ccgggaaaga gttccgtcat
     8461 ggagcggccg agcgaggtgg tgaggtcgcc gccgagctcc cggacgctgg atgcgttggc
     8521 ccacaacagg cgcgcgccgg gtccgtagat ggtcagggtc accggcgact gggtgacgag
     8581 cccctccagc atcgcctgtc gggtctccca ccagcgcagc ctctccagct cggtcgccat
     8641 gaggacggcg tggggggcct gccccgagga ggccgcgtcg ggggcggggg tcaggggatg
     8701 cagggtcacg gccacgcgta cggtgcctcc gccgcggtgg cgcacgtcca cgacggcact
     8761 gcgtgcgcca ccgagccgcg gccgccggtc ccaccgcggc tcgtccggtc cgtcgcggct
     8821 ggcgtgcggg gtggcgatca ggtccaccgc ccggcgtccc cgtacctgcg acgccgtgta
     8881 tcccaggagg gcctcggcct cgcgactcca cccgacgagc actccgtccg cggcaagcag
     8941 ggcgaaggcg gccgggggcg gtccgagatg cccgccttcg tccgccccga cgggaggcgt
     9001 gaacggcagc ccttccatgc ctccatcatc cttccgagcg ctcgcggccg cagtgcgctc
     9061 ggagcccggc cgcccctcgc ggcgcccgcg gctgtcagaa ggcgaaggcc gccccgccgt
     9121 tcagggtggc acccatggtg caggtgttgg cgaaggtgtg ggtccatgag gtgcgggccc
     9181 cctcccacac cccgtccacg ctgacggtga ccgggtcgaa gtgctgcggg cacatccggt
     9241 ccgggttcgg ggaggcgagc agaccgtcga aggcgccgcc cggcgaggtc gccttgagtt
     9301 cggcgcaggc ggcctcgggg gccgggtgcg ttccggccgc ggtcggcgcg cagctgagcg
     9361 tcacggcgcg caggacggtg gcagcgctcg cgtcggcgcc cttgctgacg ctcagtacga
     9421 gcgcggaggg cgcgtagagg ctgtcggtcc gggcttccgc gacaccggcg gcgccggtga
     9481 ggagaagaag ggcggacgtg gaagctgcaa cgaaaccgcg aagcatgacg gagactcact
     9541 ttcgattcga agaccagtgg tggtttcaac cttcagataa ccaccttgcg tacacctcgg
     9601 agcgtgtctg acacgcagag cgatgacaag ttcgcggtcg ctattcggac accgcccccc
     9661 gtataccggc gctcgcacag gtgtgcagca ggtcagagcc ggtccggggc ggttccggca
     9721 ctggtccgca ccctcccccg cgcgggcccg tcatggccgc cggcctgccc agggacgtgt
     9781 gaggtttacc gaacggtcat tcagtacgac cgattctcga cgcgagaagg gggagccgct
     9841 gccgccgggg gacgtcggcg cgacccgcgc gaccaggagg gtgtgcgcgg cgccctggtg
     9901 acccgtgcgt tccgcacata cggaaggtga cagcggcgac tgtcggggcc cgtgggggcc
     9961 gtgacaacgt cgtgtccgtc atcgaccgag ggagtgcgca gtgaacaagg ggtacgcggt
    10021 gttctgcgac gccgaccgtc acttctacga cgcgccgcac cgtctggtct tcgccgggtc
    10081 cgggagcggc tccctctacc gggcggcgac cctcccggta cccgagggct ggacctcgca
    10141 ccggacgggc gactggctcg ccctgcgtcc cctggaccac acgctccctt cgcagggctg
    10201 gaagatccac gtctcggccg ggctcgacaa cgcggaggcg gtcctcgcca cggtccgcgc
    10261 gtactgcctg gagcaggtcg tggcgttcaa gttcgtcccc agccgctatc tgctgcacca
    10321 gcgcaacgcc aagtacgcgg accgctccgc gagcggcaag ttcatcaccg tctacccggc
    10381 cgacgaccgg cagtgcgagc gggtggccac cgacctggcg ggcctccttg acggcgagcc
    10441 cggtccttac atcctgagcg acctgcgatg gggccggggc cccttacacc tgcggtacgg
    10501 aagcttcacc ctccgccact gctacgacga gcacggggaa ctgcggccgg ccctcgagga
    10561 cggctccggc acgctcgtac ccgatcggcg cggtcccgtg ttccacctgc ccgagtgggt
    10621 gacgccaccc gccttcgtgc gcccgcacct cgcggcgagg gccgcggtga ccgtggcgga
    10681 catgccgtac gagatcgaga aggcgctgca cttctccaac ggcggcgggg tgtacgaggc
    10741 ccggcaccgg cggaccggcc gacgggtcgt cctcaaggag gcccgcccgt acgccgggct
    10801 cgccgcggac ggggcggacg ccgtgacccg gctgcaccgc gaacgcgacg cgcttcggca
    10861 gctgtcgggg ctcccctgca cgccggaggt cctcgacagc ttcacgatcg gcgagcacca
    10921 cttcctggcc ctggagttcg tcgagggcaa gccgctcaac accttcttcg cgcggaggca
    10981 tccgctgatg gaggccgagc cgtcggccga gaggatcgcc gagtacacgg agtgggccct
    11041 gcggatccac gggctcgtcg agcgggccgt ggccgaggtg cacgcacgcg ggatcgtctt
    11101 caacgacctg cacctgttca acatcatggt gtccgaggac gagtcctcgg tgacgctcct
    11161 ggacttcgag gcggccaagc ccgccgcgga gggcggtcgt cagaccgtcg ccaacccggc
    11221 gttcgtggca ccggccgacc gacgcggctt cgacgtggac cgttacgccc tcgcgtgcct
    11281 ccggatcgcc ctgttcatcc cgctcacgag tctgctggcc gtcgaccggg ccaaggccgc
    11341 gcatctcgcg gaggcggcgg cggcgcggtt cccgctgccg cccggtttcc tggacgaggc
    11401 ggtgcgggag atcctgcgcg atccggccgg cgacccgccc ggccggaggg gacgggcacc
    11461 tgaacgcccc tcggggcgca cccggttcct gcccgtggag ccgggagact ggccggcggc
    11521 ccgggactcc ctggtacgcg ccgtcatggc atcggcgacg cccgagcggg acgaccggtt
    11581 cttccccggc gacatcgccc agttcgccac cgccggcggc ggcatgaccg tgggacacgg
    11641 caccgccgga gtgctgtacg ccctgcgcga gagcgggggc ccacgatgtc cggaggccga
    11701 ggacgggctg ctgcgccacg ccaagcgacc cgactccggc acgccgctcg gcttctacga
    11761 cgggctgacc ggagtcgcct ggaccctcga ccggctcggg cacgcggccg ccgcgctcga
    11821 cctggccgca ctcgtccagg aacaggactt cgacgccctc gcgcccgacc tgcacggcgg
    11881 gacggccggt atcggcctcg ccctggacgc cctggccacc accaccggtg agagcggcct
    11941 ccacgcggcg gccctgcgct gcgccgagct gtcggcccgc cccctcgggg cgtccgcccg
    12001 gacggcgggg gccgcgtcgg gcaaggtgcg gacggggctg ctgcacggcg gtgccgggcg
    12061 ggccctgctg ttcatacggc tctacgaacg cacgcgggac tccgcgctgc tcgacctcgc
    12121 cgccgacgcg ctccacgacg acctctcccg ctgcgtccgc ggcgcctccg ggaccctcca
    12181 ggtcgacgag ggctggcgca cgatgccgta cctcggcgcc ggcagcgtgg gcatcggcat
    12241 ggtgatcgac gactacctgc tccaccggca cgacgatgcc ctggaccggg cgcgacacga
    12301 catcgtgcgg gcggcgcagg ccaccttcta cgcccagccg ggtctcttcc gcggcgtcgc
    12361 cggcatggtc ctccacctcg ctcgcacgaa cgccggcggg cccggtacga cccccgaaga
    12421 cgtacgccga caggtgggat gcctcacctg gcacgccatg acctaccagg gccatctcgc
    12481 cttccccggc gagcagatga tgcgcctctc catggacctc tccaccggca ccgcgggcgt
    12541 cctgctggcc ctcgcggcgg cgctgggcga ccgcccggcc cacctgccgt tcctcccgcc
    12601 gctcccgcgg ccccacgaac cggccccgtg acggggtcgt cccgcacaac cgtcctctac
    12661 gaaaggcaac gatcatgaac ctgttcgacc ttcagtcgct ggagaccccc aaggacgagg
    12721 ccatcggcga cgtcgagacc ggcagccgcg cgagcctcct gctctgcggc gacagcagcc
    12781 tcagcgtgac gacctgtaac tgaccccatc cggcttcccg cacggcgccc cgagcgccgg
    12841 tgtggagtca cggtgcccct ggagcgctgc tcccggggca ccggccgtcg gggcggcacc
    12901 ccgtggcccc gccgccgggg ccgcacaccc gccgccccgc gagaaggccg ctcccgtagg
    12961 agcagagagg gcatcggatg gcctggccga ccggctccga ccggctgttc gccggcgccg
    13021 tacggcacac cgcgggcctc accgcggcgc tgctgctctg ctcggtcgtc ggcgccgcct
    13081 gctcgctcgc cgtacccgcg ctcgccggca ggaccctgga catgctgctg cgccaccggc
    13141 ccggcgcgga gacgtggctc gtgtggaccg cggtgctcct cgtcgccgag atcctcaacg
    13201 agaccggcgc cgtgctcctg acccagctct ccaacgcccg cgccaccgcc tggtaccggc
    13261 tgcgcgcgct gggcggcctc ctcgggaccg cgccccaccg tgccgcacac ctctcgggcg
    13321 gcgacgtcgc cgcccggctg tgcgtcaacg ccaccgacag cggcaccgca ccggcggccc
    13381 tcgcgacctc ggtgtcgtcc gtactcgtac cgatcggggc gctcgtcgcc ctggcactca
    13441 tccacccctg gaccgcggtc gtcttcgccg ccggtctgcc gctgctcctg ctgctgctgc
    13501 gcgcgttcgc cacgcagtcc tcggactcgg tcgcccggta ccagcgggct caggcgtcca
    13561 tcgcgacccg gctggccgaa gcactcggcg gcgcccgtac catcgccgcc gccgacacgg
    13621 cccgccgcga ggaggagcgc gtcctcgccc cgcttcccga gctgacccgg cacggcacgc
    13681 gcatgtggct cgtccacggc cgcgccgtgg cccgcagcgg cgtcctgctc ccgctgctca
    13741 ccacggccgt cgtcgcggtg gcgggcgccg gtctcgccgc cggggacgtc agtgtgggcg
    13801 aactgctggc cgcgtcccgg tacgcggcac tcgccgccgg gatcggcggg atcgcggcgc
    13861 cgctcggcac cctggtccga gcccgcgccg cggcccgccg caccaccgaa ctcgggcggc
    13921 tgacaccgat gtcgtacggc tccgccgtcc tgccggccga cgggcccggt gccctggagc
    13981 tacggggggt gcgcgtggtg cgcgggggcg tccccctgat cgcggacgtg acgctcgccc
    14041 tgggcggcgg gtcgacggtc gccgtcgtgg gccgctccgg agcgggcaag tccacccttg
    14101 cgtccgtcgc gggccggttg accgaccccg acgccggaca ggtcctcctc gacggtgtcg
    14161 acctggccga cctgtcgtcc gcggagctgc gcggggcgat cgcgtacgcc ttcgctcgcc
    14221 ccgtgttcga cggcggtgcc acggtcacgg tcggcgccgc ggtggccgcc ggggtcggtc
    14281 cccgccacgg tcccgccacg gcggagaggg tccgggaagc tgcggcggcc gcgtgcgccg
    14341 acaccttcgt acggctgctg cccctgggct acgggacccc cgtggacgag gccccgatgt
    14401 ccggcggcga agcgcaacgt ctgggactgg cgcgggcgtt catcggccgg ggacgtctga
    14461 tgatcctcga cgacgcgacg tcgagcctcg acacggccac cgagcggcag gtggaagtcg
    14521 ccctcgcggc gtcaccccgc ccgtgcacca ggctgatcgt cgcccaccgg gtgtccacag
    14581 ccgcccgggc ggaccgggtg gtctggatgg aggcgggccg cgtacggggc tgtggaccgc
    14641 accacctgct gtgggaggac ccggactacc gtgcggtgtt cctggcggag acctcccggc
    14701 cgggcgccat ggcgcctgcg gcgggggcgg gggcgggcga gtgacagcgg cgcccggcac
    14761 gggccggacg caggatccga cggcgccgac tgcgccgacg gcggcggacg ccccagcggc
    14821 ggcgtccgct ccgggagtcg cggacgggtc tcggcgcgtc acatccccgg tccggtccct
    14881 cctgctccgg cgcaagggcg tgctggtgag actggcggcg tggtctctcg ccgagtccgc
    14941 ccagacgttc ctgggtggct actgcgtggc ccgctccctc gacgacgggt tcatgcgggg
    15001 ctccccacgg acggggctcc tctggctggt gggggccgcc gtcgccatcg tcctcggcgc
    15061 gccggtcgtc cggggagtct tcgcccaact cccccacctc acggagaccc tgcgcgacca
    15121 cctcgtacgg gagtcggtgg tacgggcgct gcgggcggcc acgaccgcgg gcggtggcgc
    15181 ggacgccacc gcggtgtccc ggctgacgag ccagaccgag atcgcccggg acagcttcgc
    15241 cggccttgtg ctcgccaccc gttccttcgt cttcgtcgcc gcgggggccc tcgtcggact
    15301 gctgtccctc gcaccgcagt tcctcctggt cgtgctccct cccctggcgc tgggcctggc
    15361 cgtgttcacg gcatccctgc ggcccatggc acgggcccag caccgctacc tcgacgccga
    15421 cgaggtcgtc ggccgccgcg ccgagatcac ccgtgacgcc ctgcgggaca ccgtcgcact
    15481 cggcgcccag gaggcgaccg ccgcggtgaa ccgccgtgcc gtcgacgagg ccgcggccgc
    15541 ccagcgcgcc ctggcccgct gggcttccgt ccgcacgctc tccgtggcga cggcggggca
    15601 gctgcccgtc ttcctgctgc tcgcggccac cccgtggctc ctccgtcagg gcgtgaccgc
    15661 gggcgccgtc gtgggggcgc tgacctacgt cctgcagtcc ctgctccccg ccctgcacac
    15721 gctcatgacc gtcctgggag ccgccggcgc gcggctctac gtcatcctcg accggctcac
    15781 ccggccgctg cccgccgcgc ccgcgccccc gtccgcaccc gcacccggcc cggcccgcac
    15841 gggccggacg acggcggccc tggagctgca ccgcgtacgg gccgcgtacg ggcccggtgc
    15901 ccgccccgtg ctcgacgatc tggaactcac cgtcgagcag ggggagcacc tcgcggtcgt
    15961 cggcccgagc ggcatcggca agtcgaccct cctgcacgtg gcggcgggcc tgctgacgcc
    16021 ggaacagggc gacgtacgac tcctcggacg cgccgccgga gcctgcggcc cgccggaact
    16081 cgccgccctg cgcgtgctgc tcccccagga ggcgtacgtc ttcaccggca cgctgcggga
    16141 gaacctgctc tatctgcggc ccgggaccgg tcggcccgag accgatcggt ccgctgtcga
    16201 ccgggccgtg gacgcgctcg ccctggggcc gctcgtcgac cgggtgggcg ggctcgaccg
    16261 tacgctggcg cccgacgccc tctccctcgg cgaacgccag tcgatcgccc tggggcgcgc
    16321 ttatctggcc cccgccccgc tgttgttgct ggacgaggcg acctgccacc tggatcccgt
    16381 cgcggaggcg acggccgagc acgccctgag cgcccgcccc gggaccctgg tcgtcgtggc
    16441 ccaccggttg tcgtccgcgc tccgggccga ccggatcctc gtcgtcgacg gcacccgggc
    16501 ccagcacgga acgcatgcgg agctgctcgt acggtccgct ctctaccgcg acctgacggg
    16561 gcactggggc ggtgccggcg gatgagcggc cggcaccgcg gcgacgtcac gcggcggcgg
    16621 tcacgtccac ccggcgccct gggcgatccg gatggcgtcc acgcggttgc gggcgccgac
    16681 cttgcggatg acgctcgcca tgtagttgcg gacggttccc ttcgacagga acagcgtcgc
    16741 ggcgatctcg gcgatcggtg ctccgttggc ggccagcgag aggacgctca gctcacgccg
    16801 ggtcaagggc atctccgccg cctggaggaa tccgagcgcc agcgtgtcgt cgatgaagcg
    16861 ctcccccttg gccagccggt ggacggcctc cagtaatcgg cccttggggc tgtccttgtc
    16921 gacgaagccg accgcgcccg ccgcgtgggc ccgtcgcagc accccgggcc gctgccccgg
    16981 gacgagcgcc agcagagcgg agcggcccgc ggtgcccgct ccgcgcgggg gcacggacgc
    17041 ggtcgcgggc gccacggcgg tgggtggcag acactcggcg tcggcgacgt acacgtccgt
    17101 ctccgatctc tcggcggccg ggccgtgggg ccatcggggc agcgaggaga cgacctggac
    17161 gccgttcgac cgcagcagtt cctcgagcgc ggaacgcagg agccgctcct cgtagaccac
    17221 cgtcacccgt atcattccca ccccttcggt cctccgccgt gccggggtgc acgacgcgag
    17281 cagacaccct cacccctctg ccccggccac acagggggga acggggcagc gggcgcacgg
    17341 ggggcgcact ccgatgcgcc tcggccggat ccgttccgtc ttctcgaagg cggcgcaggc
    17401 cgggggcgtg cggggccgtc cgggccgtac ggggaatgtc cggttcgcac gcccctcacg
    17461 gcctacgtga ggagcacgcc cccctgtcgc tccacgccag atccgccact cgatcgtccc
    17521 cggttgatcc tttcgcggcg gggtagcgaa gcggcatggc caccgacaac gcatcccccg
    17581 ccacgaccgg ctacgtgcag cccgccatcg acgtccggag actgggcgcg gtgctcgacg
    17641 gcgagtacgc cgggatccgc ggcctcgtca ggaccaacct ggcgaggtac gcctccgtcc
    17701 tcgaggaggc cgacgacctc ggagtcgacg cgttccgcga gcgggtgcgt gaggtcgtcg
    17761 tcgagatggc cgcgaccggc cagaccggca tgggcttccc ggaggcgtac ggcgggggtg
    17821 gcgacgtcgg agcctcgatc gccgcgttcg agacgctggc gttcggtgat ctgtcggtgc
    17881 tggtgaaggt cggggtgcag ttcgggctct tcggcggcgc gatcctgcac ctgggcaccg
    17941 agcgccacca cgaggcctac ctgccgggtc tgatcaccgg tgagctgatg ggctgcttcg
    18001 ccatgacgga gaccgggcac ggctccaacg tgcaggcact cggtaccgtc gcgcggtacg
    18061 acgccgcacg tcaggagttc gtcatcacca cgcagggcga ccaggcgcgg aaggactaca
    18121 tcggcaacgc cgcccgccac gcggagctcg cggtcgtctt cgcccggctg gaggtggacg
    18181 ggaggtccga gggcgtgcac gccttcgtcg tgcccctgcg ggtcgcgggc gaggtggcgc
    18241 cgggcgtccg aatcgaggac gacggacgca agatgggcct caacggcgtg gacaacggcc
    18301 gtatctggtt cgacggggtg cgggtgccgc gcgaggcgct cctgaacagg ttcgccgacg
    18361 tcagccccga cggcgtgtac gagagctcca tcgccaaccc cgaccggcgc ttcttcacca
    18421 tgctcggcac gctcgtgcag ggccgggtca gcgtcgccgg tgccgggatc ggcgtcgcca
    18481 aggtcgccct cgccgtggcg acgaagtacg ccgtgcggcg gcggcagttc gcggcctcgg
    18541 cggacgccga ggagcaggtg ctcctcgact acggcctgca ccagcgccgg ctgcttccgc
    18601 tcatcgcccg gacgtacgcc ttgcacttcg cgcaggacgt ggtgcgctcg cacctgcacg
    18661 aggtcttctc cggcgccgag gacgacgccc cggcgcggcg gcggctcgag tcacgggccg
    18721 cgggtctgaa ggcactcggc acctggcacg ccacccgggt cgtccaggag tgccgcgagg
    18781 cgtgcggcgg cgccggctac ctcgccgtca accggttcgc cgcgctcaag agcgacagcg
    18841 acgtcttcac caccttcgag ggcgacaacc acgtcctgct gcagctcgtg gccaaggggc
    18901 tgctcaccga ccacgcgagc gagttcgagg acctcgacca gctgggtgtg gtccgttacg
    18961 tcaccggact cgccgtggag acggtcatcg agcggacctc cgcccacaag ctgctggagc
    19021 gggtacggga tctcctgccc ggcggcgacg agtgggaccg ggaggccggg ctgctcgacc
    19081 cggagtacca gctcgccatg ctccgcttcc gggaggagca catgctcgcc ggcgtggcgc
    19141 gccgcatcaa gcgcgggacg gatcagaagc gcgctcccgg cgccgtgttc tcgcaggtgc
    19201 aggaccacgt catcgcgctc gcccgcgcgc acgtggagcg gctggtggcg gaggccttcg
    19261 tcgacaaggt gcgcgcgatg cccgagggcg gggagaggga agcgctggct ctgctgtgcg
    19321 acttgttcgc cctgtcgacg atcgaggcgg accgggcctg gttcatggag cacggccggc
    19381 tgaccgtaca gcgctccaaa gcgatcaccc gcgaggtgaa cgacctctgc cgcaaggtcc
    19441 ggcccctcgc ggtcgacctc gtcgacgcgt ggggcatccc cccggagatg cttcgcgcac
    19501 cggagctggt gggaggcgat ccggaaccga cggcaccgag ccctgcggca tccgctcggt
    19561 gagtgggttc ggttgacgag ccggtgatgc gcaccggctc gtggaacggc aggtgcgacg
    19621 ccgtcagaaa tcctcctggc ggcgcacctc gaactggccg agccgcgcac gcggaaacgg
    19681 ccgtaccgac gggagaacgc tccgtgcgac gtcctcgggg attcccgtgt ccagcaggtg
    19741 acggtgtcct gccagtgcct cgcgatatgc ccgcacgatg accgcctgaa cggatctctc
    19801 ggccctcggc aggaggtaac agcggtctgc accgaactcc acgaaggaca gcccttcgcg
    19861 ggacaggtag tcgtcagccc tcaacgccgt gaactgcagt tcaaagcctg cccgcggtcc
    19921 gggggtcatc caggaagcgc ggatcgactg aacctgattg tcatcgatca tgatgccgtc
    19981 gagccccgtg accgcatcga ggatcggctt gaggacgttg tcgatgtccg ccaccagatg
    20041 ggtctgatag cggcgggact cctcgatgta ccacaccagg gacacttcga cgtcgtgggt
    20101 gaacacacct gtcgtggctg tccgcacagc tgaggccagc gcgtccttga agccggcttt
    20161 cctgaccgga ccggcctgga gcgacacggg gtccaccgcg ctgaggatgt cgacccggcc
    20221 atgaccgcgg aactcgcgca cctcgaagtc gtcttcggtc accactgaac tggacatggg
    20281 cggcatgttc tcaaccccgg agggtcgtca caagcgcgga ggatgccaag cccggcgccg
    20341 tccgcccggc ggggcggttg cgcccacgac tccgcggcaa ggccgacgcg caaaggtctg
    20401 tacaaacgct gtcgccccgt cgatcatttt gtcatgtacc tgccgcccga tcgtcgggcg
    20461 gcagtcctat ggaggtgtgg gatgcaccaa aggcttgccg tcggcctgtc cgcctcggcc
    20521 ctcgctctgt tcaccaccgt cgccaccgcc actgtcgcca cggcggcccc tgccgacaag
    20581 ccccaggtgc tctccagttg gacgcagacc agcgcgtcga gctacaacct ctgggccgcg
    20641 gcccgagcca atcagggcgc ctggtccgcc tacggcttcg actggtccac cgactactgc
    20701 tccacctcgc ccgacaaccc cctgggcttc cccttctcgg cgtcgtgcgc ccggcatgac
    20761 ttcggctacc gcaactacaa ggccgccggc accttcagcg ccaacaaggc ccgtctggac
    20821 agcgccctgt acgaggacct caagcgcgtg tgcctcaact acagcggcgc cacgaagacg
    20881 acgtgcaaca gcacggcgtg gacctactac caggcggtca aggccttcgg ctgatcgacc
    20941 cgtacgcgcc gggaggcgca gccggtccgg gtgcgcctcg gggagacggg tcgaccgtgt
    21001 ctgcggaccg ttcccgcgcc ggtggcggtc ccggtccgca ggagcggctc agcgcagtcg
    21061 gcgggcgcgc aggaccacgt cgtccgtgtg gtgcgcgccg gcgccgccct ccggggacac
    21121 ccgcggccgc tgctcgtcca cctccaccgc ccagtcgtcg ccgagcagcg gcacgaccat
    21181 ggacggccag acgtagtcgg ccgggtcgaa gccggtctcg ttcacctgct gggactccat
    21241 tcccgcgtgg tggacgagca gcagtacgcc gccgaccgcg acggccgaga gcagcgcgtg
    21301 ctcggccacg cggtcgggag tgcgcagcag caccgggtac tgagcggaga ccaggtcgta
    21361 cgaggccggg ggaagcgccg cctccgtcag ggtggcgtgg acccagcgga tgtcgacgcc
    21421 ggcgtcgcgg gcgtgtccgg ccgcccgctc cagggccacg cccgagacct ccagggccgt
    21481 cacgtcccag ccgccgcgcg cgagccagac ggcgtccgcg ccctcgccgc agccgacgtc
    21541 gaggacccgt cccggggtga gcccggcgac ctcggccacg agcgcgccgt tgggccgacc
    21601 gctccacagc tgttgccggt cggcgtacct gttgtcccac tccgcccgca ccgcggggtc
    21661 tccgacgtat ccgtcggcgg tcgggaagat gtcggtggcg ggcgtcgccc atgcgatgtt
    21721 ttcagtcacg aacccaccgt tgcccatcgc ataccggaca cgccaccgct gttgccggac
    21781 cggcaaatcc aggacggcga cgggcctggc ggaccgtacg cccgtctgcg taccgcacgt
    21841 ccgttccggc gcaccgggct gcccccgcgg acgcggggcc accgaggcgg gtcgttcact
    21901 cgccggtcac gcccaggagc cggcgggtgc gggcgctcgc gccgctgagg gcgagcggga
    21961 tgcccaggct ggtgcacatg cggtgggcgc gggtgagggt gctgagggtg gcgggggtgg
    22021 ggtcggcgct cgggacggcg atgaccaccc gggtgggccg gtgcgcctgg accagggcct
    22081 ggatctggag ggcgcccgcg gcccggttgg tgacgtccag gtcgcggtgg agggtcaccg
    22141 tcaggacctg gtcgcttacg gcatggctga tgagcatgga gaccctccgc gcgggacgag
    22201 gaagacccac gtccgggcac ggtgtgggtg gttcgtccga ggatgtcacg gagatcggcc
    22261 cgacgacgct ctcgtggcgc cgacggcgcg gagtgtccgg ccggacgggc acacggcccg
    22321 ctcccgcgtg cgggccggag cccgagccgt gcagccggct cgggctccgg cgggtgcgcg
    22381 tgtggcgcgc acgggcgtgg tgcccgcctc caggacgggc cgcacgctca ccggtttcag
    22441 tgccagtact tcatggtcgt acctcctccc ccgtgtcggg acgcagggtg acctcgaagc
    22501 ggtcgagacc gcggagggtc agattgcgcc ggtggtccgg ttccgcgact gcccgtgcgt
    22561 cggggtactc cccggccagg gccccgagga ccgatccggt gagccggatc gccatggacg
    22621 cgcccagaca g
//
