LOCUS       NZ_JAIHBQ010000001     10396 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces lateritius strain Z1-26 tig00001, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIHBQ010000001
VERSION     NZ_JAIHBQ010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces lateritius
  ORGANISM  Streptomyces lateritius
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     The genome of Streptomyces lateritius
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7761152)
  AUTHORS   Yang,Y. and Zhai,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-AUG-2021) Life and Science College, Hunan Normal
            University, Juzizhou Street, Changsha, Hunan 410018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 235.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019733325.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:08:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,226
            CDSs (total)                      :: 7,130
            Genes (coding)                    :: 6,956
            CDSs (with protein)               :: 6,956
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 57 of 175
            Pseudo Genes (incomplete)         :: 135 of 175
            Pseudo Genes (internal stop)      :: 9 of 175
            Pseudo Genes (multiple problems)  :: 27 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 898545
            Orig. end                         :: 908941
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIHBQ010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10396
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="5"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10396
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10396
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5396](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5396)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(435..451)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            445..1464
                     /locus_tag="K4902_RS03925"
                     /old_locus_tag="K4902_03925"
     CDS             445..1464
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240681.1"
                     /locus_tag="K4902_RS03925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03925"
                     /product="MsnO8 family LLM class oxidoreductase"
                     /protein_id="WP_221743918.1"
                     /transl_table=11
                     /translation="MSTFPDGIRFSVLDRSRTRVGEDAPQALRDTVRLAREIEALGYHR
                     FWVSEHHGVPGVAGSAPTVLAAAVAAATSRVRVGTGGVMLPNHQPLVVAEQFGVLESLF
                     PGRVDMGVGRSVGFTDGIRRALGRDKDDADRFAEQLTELLGWFTGRQTAHPQVHARPAE
                     GLRVPPFVLATGEGATIAAAAGLPLVVGDLRGRDRLLAAVDAYRSGFRPSPWADEPYVV
                     VAGTVAVAATEAEARRLLIPEAWSLAYSRTQGVFPPLEAPERIEGLAMTEKQRGFYESG
                     LSGHVHGTEDQVAEALGRAVEETGAQEVLVTTSTYDRAALSESYRRLARAVGLTPRTA"
     gene            1775..4135
                     /locus_tag="K4902_RS03930"
                     /old_locus_tag="K4902_03930"
     CDS             1775..4135
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240682.1"
                     /locus_tag="K4902_RS03930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03930"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_221743920.1"
                     /transl_table=11
                     /translation="MQERLHDPYVRVRGAREHNLAGVDVDIPRDALVAFTGVSGSGKSS
                     LAFGTIYAEAQRRYFESVAPYARRLIHQVGAPAVGEITGLPPAVSLEQRRSSPNARSSV
                     GTVTTLSNSLRMLFSRAGRYPEGAERLDSDSFSPNTAVGACPSCHGLGRVHDTSEELLV
                     PDPELSIRQGAIAAWPGAWQGKNLRDVLDTLGYDVDRPWRELDAKDREWILFTEEQPVV
                     TVHPVRDADRIQRPYQGTYMSARRYVLRTFSDSKSPTLRTKAERFLTSAPCPVCGGARL
                     RPEALAVTFAGRTIAELAGLPLTTLSGLLAEAGAEGTETARVLTADLVARIVTVTELGL
                     GYLSLDRATPTLSNGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTEALLVVLDRL
                     KAAGNSVFVVEHHLDVIRHADWLVDVGPHAGVHGGRVLHSGPPDGLAEVEASATRRFLF
                     DRAPAPGREVREPAGWLRTGPVTRHNLRAVDAAFPVGVLTAVTGVSGSGKSTLVGALTE
                     EVAGVERLVTVDQRPIGRTPRSNLATYTGLFDVVRKLFTETEEARAHGYKAGRFSFNVT
                     GGRCETCQGEGFVSVELLFLPSTYAPCPDCHGARYNPETLEVRLRGLTIAEVLDLTVEA
                     AAAFFDDTPAAARSLRALLDVGLGYLRLGQPATELSGGEAQRIKLASELQRPHRSPTLY
                     VLDEPTTGLHPADVEVLMRQLHGLVDAGHSVVVVEHDMDVVATADWVVDLGPGGGDEGG
                     RIVAAGPPDRVARAAGSRTAPYLARSTGLAGRP"
     gene            complement(4150..4977)
                     /locus_tag="K4902_RS03935"
                     /old_locus_tag="K4902_03935"
     CDS             complement(4150..4977)
                     /EC_number="1.14.18.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="K4902_RS03935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03935"
                     /product="tyrosinase MelC2"
                     /protein_id="WP_073813380.1"
                     /transl_table=11
                     /translation="MTVRKNQATLTADEKRRFVNALLELKRSGRYDTFVTTHNAFIMSD
                     TDSGDRVGHRSPSFLPWHRRFLIEFEQALQSVDPTVNLPYWDWTADRTSRSSLWAPDFL
                     GGTGRARDGQVTDGPFARVGNRWTITVRVDGRDYLRRDLGAGGRQLPTRAEVDSVLAME
                     TYDTAPWNSSSDGFRNHLEGWRGVNLHNRVHVWVGGQMGTGVSPNDPVFWLHHAFIDKL
                     WADWQARHPRSTYLPAAGTANVVDLGDTMRPWNDVTPADMLDHTRHYTFDTAA"
     gene            complement(5001..5396)
                     /locus_tag="K4902_RS03940"
                     /old_locus_tag="K4902_03940"
     CDS             complement(5001..5396)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038019.1"
                     /locus_tag="K4902_RS03940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03940"
                     /product="apotyrosinase chaperone MelC1"
                     /protein_id="WP_073813378.1"
                     /sec_met_domain="melC (E-value: 6.8e-46, bitscore: 154.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSITRRRALGVAAGAAGAAAGLALTHSAVAAVPRAATAPAAGPA
                     PAAFDEVYQGRRIRGGASHGGGHHGGHHGGGYSVTIDGEELHVMRNADGTWISVINHYE
                     PVATPKALARAAVRELQGAPLVPLTLT"
     misc_feature    complement(5449..5464)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.41"
                     /tool="antismash"
     gene            complement(5689..6438)
                     /locus_tag="K4902_RS03945"
                     /old_locus_tag="K4902_03945"
     CDS             complement(5689..6438)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038018.1"
                     /locus_tag="K4902_RS03945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03945"
                     /product="succinate dehydrogenase/fumarate reductase
                     iron-sulfur subunit"
                     /protein_id="WP_073813376.1"
                     /transl_table=11
                     /translation="MKLTLRVWRQRDADAPGAMSTYEVDGISADMSFLEMLDTLNEDLI
                     LRGEDPVAFDHDCREGICGACSLVINGDAHGPERTTTCQLHMRSFRDGDTIDVEPWRAS
                     AFPVVKDLVVDRSAFDRVIQAGGYITAPTGAAPEAHATPVPKADADSAFEHAECIGCGA
                     CVAACPNGSAMLFTSAKINHLNVLPQGSPERESRVLDMVGQMDAEGFGGCTLTGECATA
                     CPKGIPLPSITAMNREWLRARRKAGRG"
     gene            complement(6435..8381)
                     /locus_tag="K4902_RS03950"
                     /old_locus_tag="K4902_03950"
     CDS             complement(6435..8381)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386402.1"
                     /locus_tag="K4902_RS03950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03950"
                     /product="fumarate reductase/succinate dehydrogenase
                     flavoprotein subunit"
                     /protein_id="WP_073813374.1"
                     /sec_met_domain="DAO (E-value: 7.3e-07, bitscore: 27.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFLDYTTGEPVVDHKAPAGPVAERWDTRRFQAKLVNPANRRKHR
                     IIVVGTGLAGGSAGATLAEQGYHVVQFCFQDSPRRAHSIAAQGGINAAKNYRNDGDSIH
                     RLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVS
                     RTFYARGQTGQQLLLGAYQALSRQIAAGNVEMHARTEMLDLVVVDGRARGIVARDLITG
                     EISTHYADAVVLASGGYGNVFYLSTNAMNSNATAVWRAHRRGAYFANPCFTQIHPTCIP
                     RTGDHQSKLTLMSESLRNDGRIWVPKAKGDTRPAADIPEDERDYYLERIYPSFGNLVPR
                     DIASRAAKNVCDEGRGVGPGGQGVYLDFADAIRRMGRAAVEERYGNLFDMYERITAENP
                     YEVPMRIYPAVHYTMGGLWVDYDLQTTVPGLFAIGEANFSDHGANRLGASALMQGLADG
                     YFVLPATINDYLARHPRTEPVTDDHPAVREVLAETEDRLHLLLSVDGDRTPDSFHRELG
                     ELMWEYCGMARTEAGLRTALARIPEIREEFWSRVKVPGTGAEFNQSLEKANRIVDYLEL
                     AELMCLDALHRAESCGGHFREESQTPDGEAARRDDAFAYAAAWEFRGTGDAPVLHKEDL
                     TFEYVHPTQRSYA"
     gene            complement(8383..9108)
                     /locus_tag="K4902_RS03955"
                     /old_locus_tag="K4902_03955"
     CDS             complement(8383..9108)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977935.1"
                     /locus_tag="K4902_RS03955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03955"
                     /product="succinate dehydrogenase"
                     /protein_id="WP_073813372.1"
                     /transl_table=11
                     /translation="MALAPTRDKATGRPPSPTPSRGFLSSTLGKKTVMAVSGLLMLGYL
                     VAHVAGNLKVFFGPEEFNAYGHWLRVMGAPVLHHGWALWLVRIVLLAAVVAHAVCAYQL
                     SRRDLRARPTAYVHRRRRASYATRTMRWGGVILALFIVWHVLDLTTGTVHPGGFEEGRP
                     YQNVVDTFSTWYGNVIYIVAMLAVGLHVRHGFWSAAQTLGVGSARRERLLRGLANGLAL
                     VLTVGFISVPVAVMTGVVG"
     misc_feature    complement(9184..9204)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            9205..10107
                     /locus_tag="K4902_RS03960"
                     /old_locus_tag="K4902_03960"
     CDS             9205..10107
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308423.1"
                     /locus_tag="K4902_RS03960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K4902_03960"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_073813858.1"
                     /transl_table=11
                     /translation="MQFQQLLYFVAVAETRHFTRAAERVHVSQPSLSQQIKALEQELGA
                     ELFSRARGNITLTDAGEALLPLARRILADTETARIEVQELAQLKRGRVRLGATPSLCTG
                     LLPDVLRAFHDLHPGIELLIEESGSHDLVRELARGALDLALVVLPLPTPSPALTTVELL
                     REDLVVVSSASAPAPRRPVRIADLRDQPLVMFRHGYDLRELTVGACRAEGFEPTFTVEG
                     GELDAVLGFVRAGLGLAVVPAMVAARAGRDLRVTALARPGLRRTIALAHRSDVAPPRAA
                     RELQRMLLASRRGRAGEPA"
ORIGIN
        1 ccaccgccgc ctcgcggcac agcgcgacgc cctcgtcgag cggcgggtcg tcgggcgccg
       61 cggcgaagaa ggcgtcccag tccttggggc gccgctccag gaagtgctgg cggtgggcgg
      121 tcgcggcgag cgtgttgtcg aggtcgaaga cggccagggg ccggttgtcg gctgtcacgg
      181 gcccagccta ggagccatgt gcggcagacc ggcgcccgcg tgccggacgc gggtcacggg
      241 cccgcccagg agccgcgcgc cgggggccgg tcgcccacgt ggcggacgca gcgggtcacg
      301 ggcccggccg tccgccgcgg cccggcgccc gcgtgccgga cgccgggtca cgggtccgcc
      361 cgggagccgc gcgtcggggg ccggtccccc acgtgccgga cgcccctgcg ggaatccctc
      421 ccctcacccg gcgttgcacc ccttgtgagc acctttcccg acggcatccg cttctccgtc
      481 ctcgaccgct cccgcacccg ggtgggcgag gacgcccccc aggcgctgcg cgacaccgtg
      541 cgcctcgcgc gggagatcga ggccctcggc taccaccgct tctgggtgtc ggagcaccac
      601 ggcgtgcccg gggtcgccgg ctccgcgccg acggtcctcg ccgccgccgt ggccgccgcc
      661 acctcccgtg tccgcgtcgg tacgggaggg gtgatgctcc ccaaccacca gcccctcgtg
      721 gtggccgagc agttcggcgt cctggagtcc ctcttccccg gccgcgtcga catgggcgtc
      781 ggccgctcgg tcggcttcac cgacggcatc cgccgggccc tcgggcgcga caaggacgac
      841 gccgaccgtt tcgcggagca gctcaccgag ctcctcggct ggttcacggg aaggcagacc
      901 gcgcacccgc aggtgcacgc caggcccgcg gagggcctgc gggtcccgcc cttcgtcctg
      961 gccaccggcg agggcgcgac gatcgcagcg gccgccggtc tgccgctggt cgtcggcgat
     1021 ctgcgcgggc gcgaccggct gctggccgcc gtcgacgcgt accgctccgg tttccgcccg
     1081 tccccgtggg ccgacgagcc gtacgtggtc gtcgccggga cggtcgcggt ggccgcgacg
     1141 gaggcggagg cccggcggct gctgatcccg gaggcctggt ccctcgcgta ctcgcgcacc
     1201 cagggcgtct tcccgccgct cgaagcgccc gagcgaatcg aggggctggc gatgacggag
     1261 aagcagcgcg gcttctacga gtcggggctg agcggccatg tgcacggcac ggaggaccag
     1321 gtggcggagg cgctggggcg ggcggtcgag gagaccgggg cccaggaggt cctcgtcacg
     1381 acgagcacct acgaccgggc ggcactgagc gagtcgtacc ggagactggc ccgtgccgtg
     1441 gggctgacgc cgcggaccgc ctgacgtacg gccctggggc cggaggggga cgggccctcc
     1501 cgggtcgacg ccttccggct ccgggccgga aaggggacgg gcgccccggg gccgacgccg
     1561 gagccgcgac ggtgagccgg cgccccgggt cgtccgacac cggaccccgg gcccgggaga
     1621 gccggcgcgc ccccgacgcc agagccgtgg ccacaggtct gaaggccggc gcgccccgag
     1681 ccgcccgacg ccggacccac ggccacgggc cggcgccccg ccctcgcacg gcccccgaac
     1741 agggcaaacg aggcccagtg gataaaatcg ccccatgcag gagagactcc acgacccgta
     1801 cgtccgtgtc cgcggcgccc gtgagcacaa cctcgccggg gtggacgtcg acatcccccg
     1861 cgacgcgctc gtcgccttca ccggggtctc cggctccggc aagtcgtccc tggcgttcgg
     1921 cacgatctac gcggaggcgc agcggcgcta cttcgagtcg gtggccccgt acgcacggcg
     1981 gctcatccac caggtggggg cgccggcggt gggcgagatc accgggctgc cgccggcggt
     2041 ctccctcgaa cagcgcaggt cctcgccgaa cgcccggtcc tccgtcggca ccgtgaccac
     2101 gctctccaac tcgctgcgca tgctgttctc ccgggcgggc cgctatccgg agggcgccga
     2161 gcggctcgac tccgactcct tctcccccaa cacggccgtc ggcgcctgcc cttcgtgcca
     2221 cggcctcggg cgggtccacg acacgagcga ggagctgctc gtgccggacc cggagctgtc
     2281 gatccgtcag ggtgcgatcg ccgcctggcc cggcgcctgg cagggcaaga acctgcggga
     2341 cgtcctcgac accctcgggt acgacgtcga ccggccgtgg cgcgaactcg acgcgaagga
     2401 ccgggagtgg atcctcttca cggaggagca gccggtcgtc accgtccacc cggtcaggga
     2461 cgccgaccgc atccagcgcc cctaccaggg cacgtacatg agcgcacggc ggtacgtcct
     2521 gcggaccttc tccgactcga agagcccgac cctgcgcacc aaggcggagc gtttcctcac
     2581 cagcgccccc tgcccggtct gcggcggcgc gcggctgcgg cccgaggcgc tcgcggtgac
     2641 cttcgcgggc cggaccatcg ccgagctggc cgggctgccg ttgacgaccc tgtccggact
     2701 cctcgcggag gcgggtgcgg agggtacgga gacggcacgg gtcctcaccg cggatctggt
     2761 cgcgcggatc gtgacggtga ccgaactcgg cctgggctat ctcagcctgg accgcgccac
     2821 ccccaccctg tccaacggcg agctccagcg gctgcgcctc gccacccagc tgcgctcggg
     2881 gctcttcggt gtcgtgtacg tcctcgacga gccgtccgcg ggactgcacc cggccgacac
     2941 ggaggccctg ctcgtggtgc tggaccggct caaggcggcc gggaactccg tcttcgtcgt
     3001 cgagcaccac ctcgatgtca tccggcacgc cgactggctg gtggacgtag gtccgcacgc
     3061 cggggtccac ggcgggcggg tgctgcacag cggcccgccg gacggcctcg cggaggtcga
     3121 ggcgtccgcg acccggcgtt tcctcttcga ccgcgcgccc gcacccggcc gggaggtgcg
     3181 ggagccggcc gggtggctgc ggacggggcc ggtcacgcgg cacaacctgc gggcggtcga
     3241 cgcggccttc cccgtcggtg tcctgaccgc ggtcacgggt gtgtccggct ccgggaagtc
     3301 cacgctcgtc ggcgcgctga ccgaggaagt cgccggggtg gaacgtctcg tgacggtcga
     3361 tcagcgtccc atcggccgga ctccgcgctc caacctggcc acctacaccg gtctgttcga
     3421 cgtcgtgcgg aagctgttca cggagaccga ggaggcacgg gcgcacggct acaaggcggg
     3481 ccgcttctcc ttcaacgtga ccggcggccg ctgcgagacc tgccagggcg agggcttcgt
     3541 ctcggtggag ctgctcttcc tgccgagcac gtacgccccc tgccccgact gccatggcgc
     3601 ccgctacaac ccggagaccc tcgaggtgcg gctgcgggga ctgaccatcg ccgaggtcct
     3661 cgacctgacc gtcgaggccg ccgccgcctt cttcgacgac acccccgccg ccgcccggag
     3721 cctgcgtgcc ctgctcgacg tgggcctcgg gtacctgcgg ctcgggcagc cggccaccga
     3781 gctgtccggc ggcgaggccc agcgcatcaa gctcgcctcc gagctccagc ggccgcaccg
     3841 ctcccccacc ctgtacgtgc tggacgagcc gacgaccggg ctgcacccgg cggacgtcga
     3901 ggtcctgatg cgccagctcc acggcctcgt ggacgcgggg cattcggtgg tcgtcgtcga
     3961 gcacgacatg gacgtcgtcg ccaccgccga ctgggtcgtg gacctggggc cgggcggcgg
     4021 cgacgagggc ggccggatcg ttgcggcggg gcctccggac cgggtggcgc gggcggcggg
     4081 cagccgcacc gcgccgtatc tggcccggtc caccgggctc gccgggcggc cctgaggccg
     4141 cccggcggat caggccgccg tgtcgaaggt gtagtggcgg gtgtggtcca gcatgtccgc
     4201 cggggtcacg tcgttccacg ggcgcatggt gtcgccgagg tcgacgacgt tcgcggtgcc
     4261 cgcggccggc aggtacgtcg accgggggtg gcgggcctgc cagtcggccc acagcttgtc
     4321 gatgaaggcg tggtgcagcc agaacaccgg gtcgttgggc gagaccccgg tgcccatctg
     4381 accgcccacc cagacgtgga cgcggttgtg gaggttcacc ccgcgccatc cctccaggtg
     4441 gttgcggaag ccgtccgacg agctgttcca gggggcggtg tcgtaggtct ccatggcgag
     4501 gacggagtcc acctcggcgc gggtggggag ctggcgtccg cccgccccga ggtcgcgccg
     4561 gaggtagtcg cgcccgtcga cgcggacggt gatcgtccag cggttgccga cgcgggcgaa
     4621 ggggccgtcg gtgacctggc cgtcgcgggc gcgtccggtg ccgccgagga agtcgggcgc
     4681 ccagagcgag gagcgggagg tgcggtcggc cgtccagtcc cagtagggga ggttgacggt
     4741 cgggtcgacg gactgcagcg cctgctcgaa ctcgatgagg aagcgccggt gccaggggag
     4801 gaacgagggc gaacggtggc cgacgcggtc gccgctgtcg gtgtcgctca tgatgaaggc
     4861 gttgtgcgtg gtgacgaagg tgtcgtaccg gccggagcgc ttgagctcca ggagggcgtt
     4921 gacgaagcgc cgcttctcgt cggcggtgag ggtggcctgg ttcttgcgta cggtcatgac
     4981 gggtgccgct cctggatcgg tcaggtgagg gtgaggggta cgagcggggc gccctggagt
     5041 tctcggacgg ccgcgcgggc cagtgccttc ggcgtggcga ccggctcgta gtggttgatc
     5101 acgctgatcc aggtgccgtc ggcgttccgc atgacatgca gttcctcacc gtcgatcgtg
     5161 acggagtagc cccctccgtg gtgtcccccg tgatgaccgc ccccgtgcga ggcccctccc
     5221 ctgatgcggc ggccctggta gacctcgtcg aaggcggccg gggccgggcc tgccgcggga
     5281 gcggtggcgg cccggggcac ggcggcgacg gcggagtggg tcagggcgag gccggcggcg
     5341 gcgcccgcgg cgcctgccgc gacgccgagg gcccggcggc gggtgatgct ggacatgaaa
     5401 cccccagatg gtcggtacga ccgggggttt ggtcatatgc ccccggccgt ttccatcagt
     5461 acccgggagt gtcggcgcgg cggaaatctc cgggaagtgg ttggccgcga agtggacaac
     5521 atgccatgaa atgtacagag ttgaacggag ttgatcttgc tgtcgcacag gacaggagca
     5581 ccccggagcg aagatcttac ggagaaagtg atctttccgt gaaggatctt tcgtcccggg
     5641 gtgcggggtg tggcggggcc cacgccttca gactgtccgg atccggtctc agccgcgacc
     5701 ggccttgcgc cgcgcccgca gccactcccg gttcatcgcc gtgatcgacg gcagcgggat
     5761 ccccttcggg caggccgtcg cgcactcccc cgtcagggtg cagccgccga agccctcggc
     5821 gtccatctga ccgaccatgt cgaggacgcg ggactcgcgt tcgggggagc cctggggcag
     5881 cacgttgaga tggttgatct tggccgaggt gaagagcatc gccgagccgt tggggcaggc
     5941 cgcgacgcac gccccgcagc cgatgcattc cgcgtgctcg aaggcggagt ccgcgtccgc
     6001 cttggggacg ggggtggcgt gggcctcggg ggccgcgccg gtgggtgccg tgatgtagcc
     6061 gccggcctgg atgacgcggt cgaaggcgga ccggtcgacg accaggtcct tgacgacggg
     6121 gaaggcggag gcgcgccagg gctcgacgtc gatggtgtcg ccgtcgcgga aggagcgcat
     6181 gtggagctgg caggtggtcg tgcgctccgg cccgtgcgcg tcgccgttga tgacgaggct
     6241 gcacgcgccg cagatgccct cgcggcagtc gtggtcgaag gccaccgggt cctcaccgcg
     6301 caggatgagg tcctcgttga gggtgtcgag catctccagg aacgacatgt cggcggagat
     6361 gccgtccacc tcgtaggtgg acatggcgcc gggggcgtcg gcgtcgcgct ggcgccagac
     6421 gcgcagggtg agcttcatgc gtagctccgc tgggtggggt ggacgtactc gaaggtgagg
     6481 tcctccttgt ggaggaccgg cgcgtcgccg gttccgcgga actcccaggc ggcggcgtac
     6541 gcgaacgcgt cgtcgcggcg ggcggcctcg ccgtccgggg tctgggactc ctcgcggaag
     6601 tggccgccgc aggactcggc gcggtggagc gcgtcgaggc acatgagctc ggcgagttcc
     6661 aggtagtcga cgatgcggtt ggccttctcc agggactggt tgaactcggc gcccgtgccg
     6721 gggaccttga cgcggctcca gaactcctcc cggatctcgg ggatccgggc gagggcggtg
     6781 cgcagtccgg cctccgtgcg ggccatcccg cagtactccc acatgagttc gccgagttcg
     6841 cggtggaagg agtcgggggt gcggtcgccg tccacggaga gcaggaggtg gagccggtcc
     6901 tccgtctcgg cgagcacctc ccgtaccgcc gggtggtcgt cggtgacggg ttccgtgcgg
     6961 gggtggcggg cgaggtagtc gttgatggtg gcggggagga cgaagtatcc gtcggccagg
     7021 ccctgcatga gggcggaggc gccgagccgg ttggccccgt ggtcggagaa gttggcctcg
     7081 ccgatcgcga agaggccggg gacggtggtc tggaggtcgt agtcgaccca gagtccgccc
     7141 atcgtgtagt ggacggccgg gtagatccgc atggggacct cgtacgggtt ctcggcggtg
     7201 atccgctcgt acatgtcgaa gaggttgccg tacctctcct ccaccgccgc ccggcccatg
     7261 cggcggatag cgtcggcgaa gtcgaggtag acgccctggc cgccggggcc gacgccgcgg
     7321 ccctcgtcgc agacgttctt cgcggcgcgg gaggcgatgt cgcgggggac gaggttgccg
     7381 aaggaggggt agatccgctc caggtagtag tcgcgctcgt cctcggggat gtcggcggcg
     7441 gggcgggtgt cgcccttggc cttggggacc cagatccggc cgtcgttgcg gagggactcg
     7501 ctcatcaggg tgagcttgga ctggtggtct ccggtgcgcg ggatgcaggt ggggtggatc
     7561 tgggtgaagc aggggttggc gaagtacgcg ccgcgccggt gcgcccgcca gacggcggtg
     7621 gcgttggagt tcatcgcgtt cgtcgacagg tagaagacgt tgccgtagcc gccgctggcg
     7681 aggaccaccg cgtccgcgta gtgggtggag atctcgcccg tgatcaggtc gcgggcgacg
     7741 atgccgcggg cccgcccgtc gacgacgacg aggtcgagca tctccgtacg ggcgtgcatc
     7801 tcgacgtttc cggcggcgat ctgccgggac agggcctggt aggcgccgag gaggagctgc
     7861 tggccggtct ggccgcgggc gtagaaggtg cgggagacct ggacgccgcc gaaggagcgg
     7921 gtgtcgagga ggccgccgta ctcgcgggcg aaggggacgc cctgggcgac gcactggtcg
     7981 atgatctcga cggagatctg ggcgaggcgg tggacgttgg actcgcgggc gcggaagtcg
     8041 ccgcccttga cggtgtcgta gaagagccgg tggatggagt cgccgtcgtt gcggtagttc
     8101 ttggcggcgt tgatgccgcc ctgggcggcg atggagtggg cgcggcgcgg ggagtcctgg
     8161 aagcagaact ggacgacgtg gtagccctgt tcggcgaggg tggcgccggc ggagccgccg
     8221 gcgaggccgg tgccgacgac gatgatccgg tgcttgcggc ggttggcggg gttgaccagc
     8281 ttcgcctgga agcggcgggt gtcccagcgt tcggcgacgg gtcccgcggg ggccttgtgg
     8341 tcgacgaccg gctcaccggt cgtgtagtcg aggaagctca tgtcagccca ccactccggt
     8401 catgacggct acgggtacgg agatgaagcc cacggtcagg acgagcgcga ggccgttcgc
     8461 gaggccgcgg aggagccgct cgcggcgggc gctgcccacg ccgagggtct gggcggcgct
     8521 ccagaacccg tggcggacgt ggaggccgac ggcgagcatg gcgacgatgt agatgacgtt
     8581 gccgtaccag gtggagaagg tgtcgacgac gttctggtag ggcctgccct cctcgaagcc
     8641 gccggggtgg acggtgccgg tggtcaggtc gaggacgtgc cagacgatga agagggcgag
     8701 gatgacgccg ccccagcgca tggtgcgggt ggcgtaggag gcgcgccggc ggcggtggac
     8761 gtacgcggtg gggcgggccc tcaggtcgcg gcggctgagc tggtacgcgc agacggcatg
     8821 ggccacgacg gcggcgagga gcacgatccg gacgagccag agggcccacc cgtggtgcag
     8881 caccggagcg cccatgaccc gcagccagtg gccgtaggcg ttgaactcct cggggccgaa
     8941 gaagaccttg aggttgccgg cgacgtgcgc gacgaggtag ccgagcatga gcagcccgct
     9001 gacggccatg accgtcttct tgccgagggt cgatgacagg aatccgcggg acggtgtggg
     9061 ggacggcggg cggcccgtcg ccttgtccct cgtgggtgcc agagccatgc ctacgacgct
     9121 agggcccaag gaaccgagag gtccaagaca tggtccggct gatctcgata ggtaccacct
     9181 atgcacatcg cctacgctgg gctcatgcag ttccagcagc tcctctactt cgtcgccgtg
     9241 gccgagaccc ggcacttcac ccgggccgcg gagcgggtcc acgtctccca gccctcgctc
     9301 tcgcagcaga tcaaggccct ggagcaggag ctgggcgccg agctcttcag ccgcgcccgg
     9361 gggaacatca cgctcaccga cgcgggcgag gcgctgctgc cgctcgcccg ccgcatcctc
     9421 gccgacaccg agacggcgcg gatcgaggtg caggagctgg cccagctcaa gcggggccgg
     9481 gtgcggctcg gcgcgacccc gagcctgtgc accggactgc tgccggacgt cctgcgggcc
     9541 ttccacgatc tgcacccggg gatcgagctc ctgatcgagg agagcggctc gcacgatctc
     9601 gtacgggagc tggcgcgcgg ggctctcgac ctggcgctcg tggtgctgcc gctgccgacc
     9661 ccgtcgccgg cgctgaccac ggtcgagctg ctgcgggagg acctggtggt ggtctcgtcc
     9721 gcgtcggcgc cggcgccgcg ccgtccggtg cgcatcgcgg acctcaggga ccagccgctc
     9781 gtgatgttcc ggcacggcta cgacctgcgg gagctgaccg tgggcgcctg ccgggcggag
     9841 gggttcgagc cgacgttcac ggtcgagggc ggcgagctgg acgcggtcct cggtttcgta
     9901 cgggccgggc tcgggctcgc ggtcgtcccg gcgatggtgg cggcgcgcgc gggccgggac
     9961 ctgcgggtga ccgccctcgc ccggcccggc ctgcggcgga cgatcgccct ggcccaccgc
    10021 agcgacgtgg ctcccccgag ggcggcacgg gaactccagc ggatgctgct cgcctcgcgc
    10081 cgcggccggg ccggggaacc cgcctgaccg ggccggaccg ctccgacggg ggaactccgg
    10141 ccgacccggc cgggccgcgc tacgaccggg aaacccgacc gaccagaccg ggccacgctc
    10201 cgaccacggc acccgaccga ccagacctgg ccaccctcca accgggaaac ccgaccgacc
    10261 agaccgggcc acgctccgac cagcgcaccc caccgaccag accggaccga tccggccggg
    10321 tggacatccg cgggcggcag gcgcggggcg gctgcgagca tgcccgcatg gcccacgctc
    10381 tcgaacacct ggtcct
//
