LOCUS       NZ_AP024565            23348 bp    DNA     circular CON 26-SEP-2024
DEFINITION  Microcystis aeruginosa strain NIES-88 chromosome, complete genome.
ACCESSION   NZ_AP024565
VERSION     NZ_AP024565.1
KEYWORDS    RefSeq.
SOURCE      Microcystis aeruginosa
  ORGANISM  Microcystis aeruginosa
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Chroococcales; Microcystaceae; Microcystis.
REFERENCE   1
  AUTHORS   Phan,C.-S., Matsuda,K., Balloo,N., Wakimoto,T. and Okino,T.
  TITLE     Argicyclamide A-C unveil enzymatic basis for guanidine
            bis-prenylation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5478552)
  AUTHORS   Matsuda,K. and Wakimoto,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2021) Contact:Kenichi Matsuda Hokkaido University,
            Graduate school of phrmaceutical sciences; Kita 12, Nishi 6,
            Kita-ku, Sapporo, Hokkaido 060-0812, Japan URL
            :https://www.pharm.hokudai.ac.jp/tennen/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Coverage                   :: 87x
            Sequencing Technology             :: DNBSEQ; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019704275.1-RS_2024_09_26
            Annotation Date                   :: 09/26/2024 11:16:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,602
            CDSs (total)                      :: 5,550
            Genes (coding)                    :: 5,071
            CDSs (with protein)               :: 5,071
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 479
            CDSs (without protein)            :: 479
            Pseudo Genes (ambiguous residues) :: 0 of 479
            Pseudo Genes (frameshifted)       :: 110 of 479
            Pseudo Genes (incomplete)         :: 380 of 479
            Pseudo Genes (internal stop)      :: 101 of 479
            Pseudo Genes (multiple problems)  :: 91 of 479
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:54:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2275194
            Orig. end                         :: 2298542
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024565.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23348
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="8"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23348
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23348
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13348](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13348
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(332..>575)
                     /locus_tag="LC603172_RS28040"
                     /pseudo=""
     CDS             complement(332..>575)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0032196 - transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012266743.1"
                     /locus_tag="LC603172_RS28040"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="CYFANLYHSWERGLKEHTNDLMRQFFPKGTNFSHHQTSSGRPSDG
                     LNQPSTAKSP"
     gene            complement(778..924)
                     /locus_tag="LC603172_RS11380"
                     /old_locus_tag="MAN88_22050"
     CDS             complement(778..924)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MAN88_22050"
                     /product="hypothetical protein"
                     /protein_id="WP_155726695.1"
                     /transl_table=11
                     /translation="MKTQTTAELNRTTEVAFAGLPASHLKTFTFDNGQEFSGYEQAAGL
                     GVE"
     gene            complement(953..1114)
                     /locus_tag="LC603172_RS11385"
                     /old_locus_tag="MAN88_22060"
     CDS             complement(953..1114)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MAN88_22060"
                     /product="hypothetical protein"
                     /protein_id="WP_199309343.1"
                     /transl_table=11
                     /translation="MSIKYSSEIKAYNRVGIEDRPAIAEEKTEIGHWEGDTIIGGNHLG
                     AIATYLCR"
     CDS_motif       complement(992..1114)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSIKYSSEIKAYNRVGIEDRPAIAEEKTEIGHWEGDTIIGG"
                     /locus_tag="LC603172_RS11385_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(953..991)
                     /prepeptide="core"
                     /locus_tag="LC603172_RS11385_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.80"
                     /molecular_weight="1313.5"
                     /monoisotopic_mass="1312.7"
                     /core_sequence="NHLGAIATYLCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIKYSSEIKAYNRVGIEDRPAIAEEKTEIGHWEGDTIIGG
                     "
                     /leader_location="[991:1114](-)"
     gene            <1077..1184
                     /locus_tag="LC603172_RS28045"
                     /pseudo=""
     CDS             <1077..1184
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012267855.1"
                     /locus_tag="LC603172_RS28045"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="D-glycero-D-manno-heptose 1-phosphate
                     guanosyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYALISDEYFIDIGIPQDYDKSQQELPSLISKVSF"
     gene            1262..1615
                     /locus_tag="LC603172_RS11390"
                     /old_locus_tag="MAN88_22070"
     CDS             1262..1615
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012745.5"
                     /locus_tag="LC603172_RS11390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22070"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_260324555.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.4e-06,
                     bitscore: 25.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLASFNQPILSIVSPTIGNFSGYWLQQLLSVQGNVEFILVYPPGT
                     TAAFIADPRVKILYSLYKGETPQRAFGLMNATGQYILALDDDDFVHPDVVSHIPHPQLS
                     HKLSPSRDLSKNT"
     gene            1717..3375
                     /locus_tag="LC603172_RS11395"
                     /pseudo=""
     CDS             1717..3375
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012264372.1"
                     /locus_tag="LC603172_RS11395"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS1634 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNQSTEIEVKNLDHLGLVAGIIDEIGIVEIINEQVSIERGEIVTA
                     GQVVKAIILNGLGFVSRALYLFPQFFEDKATEHLLGEGIEAKHLNDDKIGRVMDKLYQL
                     NVSVIFLLISLAAVKKFGVATENSHLDSTSLSVEGEYNKEYPTVEILKSGAVGEEIETR
                     QQPIKITYGYSRDRRPDLKQFMIDLIVSGDGDVPLFLKVGDGNEADKAVFGQIAREFQK
                     QVDFDSLIVGDSALYSKENLKLMKEMRWLSRVPFSIKEAQELVDSISEKELTDAEIPGY
                     SWWETSSNYGGIEQRWLLVESQARQESDLKKLEKKIEQEKNWA"
     gene            complement(3524..4567)
                     /locus_tag="LC603172_RS11400"
                     /old_locus_tag="MAN88_22100"
                     /pseudo=""
     CDS             complement(3524..4567)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012264517.1"
                     /locus_tag="LC603172_RS11400"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22100"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MINLEFTEEEKNSLS"
     misc_feature    complement(4972..4986)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.16"
                     /tool="antismash"
     gene            4977..5126
                     /locus_tag="LC603172_RS11405"
                     /old_locus_tag="MAN88_22110"
     CDS             4977..5126
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039246.4"
                     /locus_tag="LC603172_RS11405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22110"
                     /product="anacyclamide/piricyclamide family prenylated
                     cyclic peptide"
                     /protein_id="WP_221275467.1"
                     /transl_table=11
                     /translation="MKNKTLLPQLTTPVERQHQAAASSESGANSLSASRVFIVLPPFAE
                     DGAE"
     gene            complement(5378..5557)
                     /locus_tag="LC603172_RS11410"
                     /pseudo=""
     CDS             complement(5378..5557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002784554.1"
                     /locus_tag="LC603172_RS11410"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="M"
     CDS             complement(5714..5929)
                     /gene="allorf_2280908_2281123"
                     /locus_tag="allorf_2280908_2281123"
                     /protein_id="allorf_2280908_2281123"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLCNGGGLEGMKPLYRKTLLRLFPIVFDLERANQLSLLPDKDLVD
                     LCPLIELYQVTKSPILFFYTVLKTLI"
     CDS_motif       complement(5897..5929)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLCNGGGLEGM"
                     /locus_tag="allorf_2280908_2281123_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5714..5896)
                     /prepeptide="core"
                     /locus_tag="allorf_2280908_2281123_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.10"
                     /molecular_weight="6971.4"
                     /monoisotopic_mass="6967.0"
                     /core_sequence="KPLYRKTLLRLFPIVFDLERANQLSLLPDKDLVDLCPLIELYQ
                     VTKSPILFFYTVLKTLI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLCNGGGLEGM"
                     /leader_location="[5896:5929](-)"
                     /alternative_weights="6989.4"
                     /alternative_weights="7007.4"
                     /alternative_weights="7025.4"
                     /alternative_weights="7043.4"
                     /alternative_weights="7061.5"
     misc_feature    5732..5750
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.7"
                     /tool="antismash"
     gene            5966..6832
                     /locus_tag="LC603172_RS11415"
                     /old_locus_tag="MAN88_22130"
     CDS             5966..6832
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04445.1"
                     /locus_tag="LC603172_RS11415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22130"
                     /product="LynF/TruF/PatF family peptide
                     O-prenyltransferase"
                     /protein_id="WP_192846042.1"
                     /transl_table=11
                     /translation="MKSNKKLYYISAHKHAFEIDNLYPLNLFEGFVERIEKIEKTENCV
                     LESSCKIDHDKLYPVRFNIGFPNNSIKQLHAVMDFFRRVESRVDVKLNLSLFQQFIGND
                     FKLDKMTDLMLGIDLRRDLSDSRLKIGLTIEDYPEKQKAAVILNNNIDEVTSNLLISNR
                     LHIGFDFYLNGRSEMELYPHIMQQDFQKLDVQQRLSKVLSPPALQVVPACTRICVGISK
                     ANRDKIIYYYLENMGDFLNYFTVNDTARKVHAYYLKQPVVEMCVALPESELLAGTTIKN
                     LNLYYLL"
     misc_feature    complement(7469..7484)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.17"
                     /tool="antismash"
     misc_feature    7883..7896
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.16"
                     /tool="antismash"
     misc_feature    complement(7884..7897)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.16"
                     /tool="antismash"
     gene            8082..8387
                     /locus_tag="LC603172_RS11420"
                     /old_locus_tag="MAN88_22140"
     CDS             8082..8387
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03798.1"
                     /locus_tag="LC603172_RS11420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22140"
                     /product="Nif11-like leader peptide family RiPP precursor"
                     /protein_id="WP_061432523.1"
                     /sec_met_domain="TIGR03798 (E-value: 5.1e-09, bitscore:
                     34.5, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPDVERFYEIARNSEELQAMLGAAEDRDSFVETAVRLGQENGC
                     NFTLDEANEFLNTKKGDAELSEQELEAVAGGRRRCNLNTRLTVCIIVSRNCWVATC"
     misc_feature    complement(8516..8529)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.57"
                     /tool="antismash"
     gene            8556..8840
                     /locus_tag="LC603172_RS11425"
                     /old_locus_tag="MAN88_22150"
     CDS             8556..8840
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03798.1"
                     /locus_tag="LC603172_RS11425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22150"
                     /product="Nif11-like leader peptide family RiPP precursor"
                     /protein_id="WP_061432524.1"
                     /sec_met_domain="TIGR03798 (E-value: 3.5e-10, bitscore:
                     38.3, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPDVERFYEIVRNSEELQAMLGAAEDRDSFVETAVRLGQENGC
                     NFTLDEANEFLNTKKGDAELSEQELEAVAGGRRGCNNTIIICRITYTRE"
     gene            8898..9059
                     /locus_tag="LC603172_RS11430"
     CDS             8898..9059
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_221275531.1"
                     /transl_table=11
                     /translation="MLLVRIRFLKTSKNTLLKKINTFGAFLAIGTVNRGFPYWSNTKSA
                     FNFYQTED"
     gene            9076..9960
                     /locus_tag="LC603172_RS11435"
                     /old_locus_tag="MAN88_22160"
     CDS             9076..9960
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="LC603172_RS11435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22160"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_072319805.1"
                     /transl_table=11
                     /translation="MVNYSLTELKGLAWLQYLEMTFPSYQTALQSLQFEDSLVAIGASV
                     EQKPVGLGLARLYPEEEAAIILSIFVESPYRCQGIGTALLAHLEQVFKQRGCRYVELVY
                     TSDQTTTPSLEHILKKAGWTPPELRVLICKAIKEQMIQASWLHKYSLPAGFTIFPWSDL
                     TEAERSRILEKQNTQAWYPEVLSPFLEEDKSEPLNSLGLRYQKEVIGWMITHRLAPDTI
                     RYSSFFVKKELQKVGRGIPLLAESIKIQCSSHIPYGMWTVSKDNPAMLSFVKRRMASYM
                     MSIKESRGVSKVL"
     gene            10001..13348
                     /locus_tag="LC603172_RS11440"
                     /old_locus_tag="MAN88_22170"
     CDS             10001..13348
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="LC603172_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22170"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_061432525.1"
                     /sec_met_domain="DUF4135 (E-value: 8.5e-107, bitscore:
                     355.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-56, bitscore:
                     189.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIPSDLKPELAKIVCQATFISERLSHQTTSTISSPFNEEIANI
                     RLNHWCKVSASGDWDKFYKRLEWNGWERDAVLRVLGTELEPETYSLPSWALTLAEIIET
                     VAQLTQENLEPLPRDSNDPKPFEDVFLPLVLVGRQKLLARLGVESLSDENLPLKRLEES
                     AYLSLEDGLYQRLFYLLVKTLDFEFSHSRPLGKNLLNLIIPNNKTTSGNKKYLAFVDKL
                     LSDGFLGFFQKYPVLGRFIATTIDFWVESTAEFLERLENDLLEIKGEFSQINDSIDSKI
                     SENQLGKIKEIKPDLSDLHHQGRSVIVLTFASGLKLVYKPKKIGVDIAFNQLLSWLNQQ
                     LENLESSAQSPLKILRILDKQTYGWSEYIEQKPCQDTAAAKRFYLQAGRLLCLLYFLGA
                     NDFHHENLIAYGDQLVMIDLETIMHHEAKWMEDSEDETAGEAAMNQLSDSVLRTALLPT
                     WEFNIDTSVAYDVSGLGSIDIQPMPVPFPVWKSINTDDMYLAQEKIDRPLQANVPMLNS
                     QPLYPNDYLKELITGFEQVYRFLIEQKENLLAANGPLSPFQTQVVRFLFRSTKVYGAVL
                     NKTRGAEFLKHGLEWSIEADILSRAFLNNQNKPQAWPILEMELQAISLGDVPYFSAATV
                     SDDLNLGGEQTIPEYFKGSCFNQVEQRLKRMNETDLAQQSRIIQLAFQSKITGSFSSER
                     SKIESKNQEEITKTLLTGDQFVTKAIEIAQEIEDQGIIGSDGSLSWISLAFVPKAERFQ
                     LQPLGESFYDGNCGVAVFFAALARVTGDSKFEKLSLNSLQSLQSFLQNADAEAIKIFAD
                     NFGIGGGVGLGAIIYCLVKIRQFLDLPHLSQEAQKVAQFMSQEIIDKDTNFDIVKGAAG
                     TVLSLLALYQDTGTNFVLDKAQACGQHLLKFCDLRYNEKSDTYKPLTGFSHGAAGIAYA
                     LLRLYEVTQDQAYSRGAQQAIAYENSKFFQEFGNWRQIIPTEEPSAAPVFWSTWCYGAP
                     GIGLGRLGGLSSYRTEEILANIEAALKTTQETPLQEVDHLCCGNLGRCEVMWVAAHKLS
                     NPQWYSAAQELASRVVNRASQTGKYQLFADLPTSVFNPCFFQGLSGIGYQFLRLAHPES
                     LPSVLLWE"
     gene            13905..15839
                     /locus_tag="LC603172_RS11445"
                     /old_locus_tag="MAN88_22190"
     CDS             13905..15839
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1076: RND efflux
                     system, outer membrane lipoprotein,"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014385.5"
                     /locus_tag="LC603172_RS11445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22190"
                     /product="TolC family protein"
                     /protein_id="WP_081106820.1"
                     /transl_table=11
                     /translation="MMLREILVNSLILSLSLIEVELAEANPLQTSFSNRFPDVSSIKDS
                     SRETTFKPKILQQKQNYLETNSKKISNDIVEIPMEKQNQSFPSELNSNPNPLLLPTEQD
                     IKQSQEHLIAITLEQAIELAKRNNQQLKIAILQLESSRAGLAEATAALYPTLSLSTTAT
                     RALSASGELAAQANEKQQIATLNGFETQLQNSQALVNFLQGRVNAKQEELDQINNIIVP
                     SPPTDIAPDLAQQIEALSPFFVPQSAVTQFAGQTQIKKSIELEFLTRDLQQAQSSLQSQ
                     QEQIASTQQSIAQISNFVTTTVDGKLSLSYNIYSPGRQANINSAKETLKINELEVTRIE
                     DQLILDVALAYYDLQQADAQVLIFQNDINDRTKRLESIELMLNVGLATKLDLLNAQVDL
                     DNAIQELRNNQAIQETTRRNLATILNLPASITPIAGDPVSQTGVWQLPLDKTILLAFKK
                     RVELEQRLAERQRSGAQQQLALAVIRPSLSIFAEYNILSLSSEDPNRFTPKGTEDGYAF
                     GLNFNWLFFDGGAATSRAKQAATGMAIAEQQYSETANNIRLEVERAYYQLQPQLRNIET
                     ATQSIKRAEEALKAAEIRFDLGVNTQTEVLDARNRLVRAQNNLINAIITYNRSFAQLQR
                     AAGFRLGEN"
     gene            complement(15801..15959)
                     /locus_tag="LC603172_RS11450"
     CDS             complement(15801..15959)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_192846043.1"
                     /transl_table=11
                     /translation="MSIVFDIERTNQLSLLPDKDLVDLCPPIEPYQVTKNHFFQLIFPK
                     SEARGSL"
     gene            16207..17118
                     /locus_tag="LC603172_RS11455"
                     /old_locus_tag="MAN88_22200"
     CDS             16207..17118
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024054.5"
                     /locus_tag="LC603172_RS11455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22200"
                     /product="UPF0489 family protein"
                     /protein_id="WP_072319816.1"
                     /transl_table=11
                     /translation="MSPIPLLIMEEHHEAFFIWNYAVLNGWIPPKKNLLLHVDEHSDFG
                     TPNLSHSLNSLNGDLENIYNFTYTELGIADFIVPSIYQGIFNELYWLRQTHNAEQTEVM
                     NHVFSLNAEGKILFVTEDVNKAGLFNLDRKPLKNKLITTTDSLVNQEKTVVVDIDLDYF
                     SCDNQAGEVLEIEVSKETYESFLNNPYDPIRIKLGGTAKMKEKNGKSYFFMQRPVMESF
                     LEKDRALKVSQAEILERIDKFSTFLIDNKIQPKLIDICRSRLSGYTPDDQWQFIESNLI
                     EKLQGIYPVEVKSIQDILSVKT"
     gene            complement(17143..20721)
                     /locus_tag="LC603172_RS11460"
                     /old_locus_tag="MAN88_22210"
     CDS             complement(17143..20721)
                     /GO_function="GO:0043531 - ADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="LC603172_RS11460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_22210"
                     /product="NB-ARC domain-containing protein"
                     /protein_id="WP_061432528.1"
                     /transl_table=11
                     /translation="MNLEEAMALAENIVFNHSGQHLSDLERLIFQASWTENRLSYEEIA
                     KTYRYSPNYIKQDVGPKLWNRLSEACGEKVKKSNFRAVLERHKAKNFSGINPIKDSYKP
                     ILQTYTLSQSKLGQDWGEAPEISVFYDRQEEIATLKQWIIRERVRLVALFGIAGIGKTY
                     LSIQLAKQIQGDFDWVIWRSLSQVMSIRKLLLDILSIISQDQENKVLVSVDDQISLLIE
                     HFRQQRCLIILDNCESIMSSGVQVGSYQDGFQEYGNFFKRIGESSHQSTLVITSREKQK
                     EVSLMQGETLPVRSLQLNGLSVSASLKLIQLKGCESKSESDSLILIEKYGRNPLILKLV
                     CGIIKDLFNCDISSFLQEQSFFVDEISNLFEEQFIRLSDLEQNILYCIALSQQSLSIDD
                     LKAEIFPISQQNLLIKLKSLIQRCLIEKYQNKFFLHPSIREYLIYRFINRITSEITTGE
                     INLLNCYAFLNINGKEHIRKLQIKLTIKPLIENLLCIYYTEEKLVERLKEILLTWQEHN
                     PQKLGYLAGNIINIFGYLNIDLTGYDFSYLSLWSSYLQDTHLHQVNLAYSDLSKCVFAK
                     QITNILSIALSPDGQILATGDVNGEIHFWQVADNQLLLSCKGHTEWVHAVAFSPDGKML
                     SSASSDQTVKLWSVEDGSCLYTFLGNNCRIYTVAFSPDGKILASGGNDYNITLRSVDTG
                     ECLQTLNGHENTVWSIAFSKNGKMIVSGSEDHTLKLWDTETGQCLQTFSGHRQWVRYVA
                     FSPDGQRLASGSGDHTVKIWDINQGRCIFTLEGHTERIRSVAFSPQGNLLASGAGDHTI
                     RIWDVEEGKCLKTIHGHNNRLTSVLFSSDGAILVSGGEDRAIRFWEVNTGQCWKTWQGY
                     GSWIQSVAFSPDGKTLASGETRTVRLWKIETDQWSKLEGHKGWISSIAYSPDGTLLATG
                     SSDYSVRLWDTKTGQCLKTLLGHTRWIRTITFSPDGLTLASCSGDATIKLWDITTGHCR
                     KTLHGHTGCLWSIQFSPDGLTLVSGSEDKTVKLWEVETGECLTTFTGHGSWVLAVAFSP
                     EGNLISSSSCDSKIKLWNVQSGKCLATLQGHDSWIQTIAFNPQGDILASGSCDRTIKLW
                     EMPSGRDLTTLTGHKQWVLSVAFSPDGQLLASGGQDETIKLWDMKTGRCCKTIRTERPY
                     EGMSITMVRGLTEAQKNTLKLLGAID"
     CDS             complement(21096..21179)
                     /gene="allorf_2296290_2296373"
                     /locus_tag="allorf_2296290_2296373"
                     /protein_id="allorf_2296290_2296373"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRSELGIVATMLKSTVILAYCHTKSGY"
     CDS_motif       complement(21147..21179)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRSELGIVATM"
                     /locus_tag="allorf_2296290_2296373_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21096..21146)
                     /prepeptide="core"
                     /locus_tag="allorf_2296290_2296373_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="1712.0"
                     /monoisotopic_mass="1710.9"
                     /core_sequence="LKSTVILAYCHTKSGY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRSELGIVATM"
                     /leader_location="[21146:21179](-)"
                     /alternative_weights="1730.0"
                     /alternative_weights="1748.0"
                     /alternative_weights="1766.1"
     gene            complement(21240..21374)
                     /locus_tag="LC603172_RS28050"
     CDS             complement(21240..21374)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS28050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_260324556.1"
                     /transl_table=11
                     /translation="MRIFYQYRPRFHTETRRAERETAKRQLLSLTGFSAPETTGETTG"
     gene            complement(21382..22092)
                     /locus_tag="LC603172_RS11465"
                     /old_locus_tag="MAN88_22220"
     CDS             complement(21382..22092)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MAN88_22220"
                     /product="hypothetical protein"
                     /protein_id="WP_192846049.1"
                     /transl_table=11
                     /translation="MLTLSETKGLTLSETKGLTLSEAEGLTPLQAAPLPCLDSGNDCLR
                     TLTEAAIERSPELQILDERIALIDRRLQLAGQRIDQANARQWTGYLTTDPIAILQNLFG
                     GGQVQQQRIAITDLEIRAADLEAAKAELERQRAAKRSQLGEQVLTLVIGYETAGDRERA
                     ILAQLSNHDLLTRITEIDYRLGGSSTETYLTRIAQREQLEIQLNRYRLERGLFSTLCDN
                     FCLWNREMLTGQDF"
     gene            complement(21977..22366)
                     /locus_tag="LC603172_RS11470"
     CDS             complement(21977..22366)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS11470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_221275532.1"
                     /transl_table=11
                     /translation="MTVEGAECGLEENRRAITLQNQQLEVEKQRAVRAAQLQEREYNKA
                     VIRTRIQEIDDALVQLATVKAPYPGTVKRLKWQGQDDRLLTVELTVDVDPERNQRVNPE
                     RNQRVNPERSRRVDSPTGRSASLSR"
     misc_feature    22627..22639
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    22676..22695
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.58"
                     /tool="antismash"
ORIGIN
        1 ggaaactcaa aaaatcaaac tagaagctat caaagaaaat ttcccaaatt tgaaaaagat
       61 gcacgagtta aaggaagaat ttagaaagat ttatgaaacc tcagagaatc cgacagaagg
      121 actgctatcc atctcggaat ggttggcaaa atcctccagt gtttttacta agagttgtca
      181 aacaatccga aactggtttg gagaaataat tagttatttc gagcgaagga caacgaatgg
      241 gatggtcgag ggaatcaaca ataaacttaa actaataaaa cggagagcct atggctttag
      301 aaactttcgg aatttttggg ttagaagtat gttatcttgg catcttgtat gttgatttag
      361 cataaagagt aacgaagagc cagaatacct cagacggagt gctatagtca agggcttttc
      421 gcagtcgatg gttgattaag tccgtcgctt ggtctacctg agcttgtttg atgatgagag
      481 aaatttgtcc ctttcgggaa aaactgccgc atgagatcgt tggtgtgttc tttcagtcct
      541 cgctcccaag aatgataaag attggcaaaa taacattaga cctcgaccta atattatctc
      601 aagacccaaa gtctttctag ttaaggaatc tacccgaata aaaattattt taattgccgc
      661 atattttttc agtgaaattg aattagcaac gatagatata cattccagcc atcgaaccat
      721 tcggttagta cgcagaccaa aagcaagctg tgactgggtt ataatttttg gagatgtcta
      781 ttcaacccct aagccagccg cctgctcgta cccactaaac tcctggccat tatcgaaggt
      841 gaaagtcttg agatgagagg ctggtaggcc cgcaaaagcc acttcagtgg tgcgattgag
      901 ttcggcggta gtctgagtct tcatgacgcg tgccactaaa aacttggagg ttttatctac
      961 atagataggt agcgatcgcc ccgagatggt tgcccccgat gatggtatct ccttcccaat
     1021 gaccaatctc agttttttct tcagcaatcg ctggtcgatc ctcaattccg actcggttgt
     1081 atgccttgat ttctgacgaa tattttattg acataggcat cccccaagat tatgataaga
     1141 gtcaacaaga attaccctct ctcatctcaa aagtatcctt ttgagagagt cttggtagtc
     1201 acctaagttc agcaaattta tgtttgtatc gtcaaattat ttctagataa attcaccaga
     1261 gatgcttgct agtttcaatc aaccgatatt atctattgtt agcccgacca tcggaaattt
     1321 ttccggatat tggttgcaac aacttttatc cgtacaggga aacgtagaat ttatcttagt
     1381 ttatcctccc ggcacaactg cggccttcat agctgaccca cgagtaaaaa ttttatacag
     1441 tctctacaaa ggagaaacac ctcaaagagc cttcggttta atgaacgcca ctggtcagta
     1501 tatactggct ttagatgatg atgacttcgt gcatccggat gttgtatccc acattccgca
     1561 ccctcaactg tcacataagc tgtccccctc cagagacttg agtaaaaata cttagctggt
     1621 gaaggttttc tcggtggccg ttagggggag cttgagaccc ctaattatga aaaaatagga
     1681 attgttggaa aactgaggcg agtggactgt tcgaccatga atcaatcaac agaaattgaa
     1741 gtcaaaaatc tagaccatct gggattagta gccggaatta tcgatgaaat aggaatcgtt
     1801 gaaattatca acgaacaagt ctcaattgag cgaggagaaa ttgtcacagc ggggcaagtc
     1861 gtgaaagcaa ttatcctgaa cggattggga tttgtctccc gggccttgta tttatttcct
     1921 caattttttg aagataaagc aaccgaacat ctgctgggag aaggcatcga agcaaaacac
     1981 ctgaatgatg ataaaattgg tcgagtaatg gacaaacttt atcaacttaa tgtttcggtc
     2041 attttcctac tcattagttt agccgccgtc aaaaaatttg gtgtagcaac cgagaattcc
     2101 catttagatt cgacttctct atcagtagaa ggagaatata acaaggaata cccaacagta
     2161 gaaatcctga aatcaggagc agtgggagaa gaaattgaaa ccagacaaca gccaataaaa
     2221 attacctacg gatactcccg cgaccgacga cctgacttaa aacaatttat gattgactta
     2281 atcgtaagtg gggatggaga tgtaccttta ttcctgaaag taggggacgg aaatgaagcg
     2341 gacaaagcgg tttttggtca aatcgcccga gaatttcaaa aacaagttga ctttgacagt
     2401 ttaatagtcg gcgatagcgc cctctatagc aaagagaatt taaaactaat gaaagaaatg
     2461 cgttggttgt ctcgagtccc cttcagcatt aaagaggctc aagagttagt cgatagcatc
     2521 tcagaaaaag agttaaccga tgcagaaata ccgggttatt cctggtggga aacaagctct
     2581 aactatgggg ggatagaaca aagatggttg ctagttgaaa gtcaagctag acaagaatca
     2641 gacttgaaaa aattagagaa aaaaatcgag caggaaaaga attgggcata agaaaaaatc
     2701 cggcaactat cccgaagaga atttgagaat agagcggtgg cgttggcgat agtcaaggga
     2761 ttatctgact ccttaaaata tcatcagtta acggagatta aagtcaatct cattccgcct
     2821 gagtctcagc agtcaaaact caaatcaaaa gacgatttat cctctcaaag ctatcaagtt
     2881 caagccgaat tagagttgaa tttggcagcg attgagaggc taaagaaacg agcaggacga
     2941 ttcgttttag caactaacga tttggagaaa aaacgattaa gcagtgagga tatactcaaa
     3001 aaatataagg ggcaacaagc tccagaaaga ggattttctt ttctcaaaga cccctgcttt
     3061 tttgccgaca gtgtctttct caaatctccc catagaatcg aggtcctggc catgctcatg
     3121 ggcttgtgcc tgttgattta tactattggc caaagacaac ttcgtctgaa tttaaaacag
     3181 caggagacgg gactgaaaaa tccgttgggt aagttaactg accgaccaac attacgctgg
     3241 atatttcagg gctttcaagg gattcatctc cgacctattc aagacaatca aaagattagc
     3301 aacttaacgg atgagaggcg caacattttg agattttttc ccaaaccttg ccaggaatat
     3361 tatctcttat cttgaccaga tggattgact tcaaggggtg acaaaactta agcactactc
     3421 gaacatctcg acgctagatg ttaagtctga ttgcccagcc attctcaaca agcactgttt
     3481 attgcgaatg accgggggaa ccctgaattt ttcgacttat actttagacg ttcataatct
     3541 gatatttatt aaacttctga aatcgtagag tcagcaagga atccagttct tttttatgtt
     3601 tcagatgggc atcattcaga cattcataaa tagctgaaga aaagtcagaa aagttctcat
     3661 aatatttacc atataaacat ttctttttga ccaatttcca cagcctttca attaaattta
     3721 gattaggcga ataagacggt agatagagta gctctattga caaagaaaga gccaattctt
     3781 caacaatttt acatttctga tagcgggcat tatctaatac gagagtgatg ggaatcatta
     3841 gtcctaaagc agctattttt gaccggagtt cacagacttg agctgctgta atataagtgt
     3901 cattcgtaac cagaataact tcatgagtta ttgcatttaa tgctcctaaa acattgaagc
     3961 gtttatgccc gctcggtgac ttaacaaaaa gtctctcaaa acaccaaaca aaaccgagaa
     4021 atgctcccat gacgaagtga gcggcatcaa caaaaaaaac agcccttttt ccttctttag
     4081 cctcatttag tctgggttct agcttttttt ctttgtagtc ctcttgttca tctgggtcag
     4141 ctttagaagg aagagaacct acttttaaac atttcattcc cattgatttt aaaaattttc
     4201 tcacttgggt aggacttcgt tttattcccg tcaattcttc tctcctatat acagcttcat
     4261 ttattgtggc tggtggattt ttctcgaagt attttttgag cgtttctttt tgagactcta
     4321 atttactttt aggtcgatag aagttgattt cttttaattt ttctattccg ccttcttgat
     4381 aatctcgaag ataggttaat aaggtatttg gcgagattcc tgctaactga caaatttttt
     4441 ggtgcggtat cttttggctc tttaaccaga gaacttccat cttcagttga acccggggat
     4501 ggggatgatg aaatctttcc taagacagtg agttcttttc ttcttccgtg aattctaggt
     4561 taatcatgtt tttaatgagt gccttgcttc taattatgac tcttaaacta tattattgtc
     4621 cctgagtaaa aaatgcaagt tgtagccgtg caaagtatag ttgccggcag cttgccgcca
     4681 actcactcct ctagataagt attttgactc acgctccttc ctctttcgag acgttgtgac
     4741 acttagggtg cggaatgtgg gtaaaatgag gagtgaccgc cgtctctgga gggggacagc
     4801 ttatgtgaca gttgagggta cggaatgtgg ggtataaatc ccactatgga gccacagaaa
     4861 agcgatatgt aacaaaatat taagtaaagt atataagggt tgacaagcag gatatgttgc
     4921 tattcaatga tagacagtag ttttgatcga accaacctta ttgggagatt atgaaaatga
     4981 aaaacaaaac tttacttccc cagctgacca ctcctgttga gcgtcagcat caagctgctg
     5041 cttcttctga atcgggagcc aattctttat ctgcatctcg ggttttcata gttttgcctc
     5101 cttttgctga agatggagct gagtaaaagt catagcattt tactcagtag ttttttccgc
     5161 ttatgcttag agattacttg acttcaagtg gttcagcaaa agcggaaatc tctgttgatt
     5221 ttgtactggt taagtgatgc aacaaaatta tttacacaat agggtagatt ttgattaaat
     5281 cataacatcc tgtgtgagaa gttctttagc taaaactgcc tcgacaaact tgggtaatta
     5341 gttttgtgtg cttacttatg ttcatactgt atcaaaatca tatagcgctt ctcacgttac
     5401 tgggatatcg gcaggtttta ccggcaaagg gtttggggtt cttcgttact tggtatggtt
     5461 cgataggggg gcataaatcg gctaaatcct tatctggtaa gagacttaat tgattagttc
     5521 gctctagatc aaaaacaatt gacaaaaatc gctaaatgcc tttctatata agtgttccat
     5581 cccttataac ccccgtccat tgcataacaa ttaccgaaga gcctggttta agttccttgc
     5641 ctgcgcctca ttctggtgaa aactgctatg gataaagatg agatttcgag catatcacag
     5701 atattagtat ttctcagatt agggttttta aaactgtata gaaaaacaaa atagggctct
     5761 tcgttacttg gtataattcg atcagggggc ataaatcgac taaatcctta tccggcaaga
     5821 gacttaattg attagctcgt tctagatcga aaacaattgg gaacaatcga agcaatgtct
     5881 ttctatataa gggtttcatc ccttctaacc cccctccatt gcataacaca aaccgaagaa
     5941 cccaaaatag taagaggata tggtgttgaa aagcaacaaa aagttatact atattagcgc
     6001 ccataaacac gcatttgaaa tagataatct atacccgctt aatctttttg agggatttgt
     6061 agaaagaatt gagaaaattg agaaaaccga aaattgtgtc ctcgaatctt cctgtaaaat
     6121 tgaccatgat aagctttatc ctgttcgttt taatatagga tttcctaata acagcataaa
     6181 acaacttcac gcagttatgg atttctttcg tcgagtagag agtcgggttg atgttaagct
     6241 caatttgtcc ctgtttcaac agtttatagg taatgacttt aaactcgaca aaatgactga
     6301 tttgatgtta gggattgatt tgcgacggga tctgtctgat tcacgcttaa aaattggctt
     6361 aactatagag gattatccag aaaagcaaaa agcagcagta attctcaaca acaatataga
     6421 tgaagtaact tctaacttac ttatcagtaa ccgcctacat ataggatttg atttttattt
     6481 gaatggtcgc agtgagatgg agctttatcc tcatatcatg cagcaagact ttcaaaaact
     6541 tgatgtgcag caaaggttgt ctaaagtttt gtcacctcct gctttacagg tcgtacctgc
     6601 ttgtactaga atttgcgtcg gcatttcaaa agctaataga gacaaaatca tttattatta
     6661 tttagaaaat atgggagact ttctcaatta ctttacagta aatgatactg cccgaaaagt
     6721 ccacgcttat tatctaaaac aaccagtagt ggaaatgtgc gtggctctgc cggaaagtga
     6781 attactagca gggacgacaa ttaagaatct caatctatat tatctgctct agcctgtatt
     6841 gttcatgaaa gtagagtaaa aaaacctggt tcttcgttac ttggtatggt tcgatagggg
     6901 gtcataaatc ggctaaatcc ttatctggta agagacttaa ttgattagtt cgctctagat
     6961 caaaaacaat tgacaaaaat cgctaaatgc ctttctatat aagtgttcca tcccttataa
     7021 cccccgtcca ttgcataaca attaccgaag agcctaaaag tctttctagt taaggaatct
     7081 acccgaataa aaattatttt aattacctca tattttttca gtgaaattga attatagcgt
     7141 ttcccaatct catgaggtac accaaaatct taactcctga atcttaactc ctgaatctta
     7201 actcctgaat cttaactcct gaatcttaac tcctgaatct taactcctga atcttaactc
     7261 ctgaatctta actcctgaat cttaactcct gaatcctgaa tcctgaatcc tgaatcctga
     7321 ctcctcaaaa cctaagactc tgtagctcac aactatggga attactatat acatttcagt
     7381 catcaaacta cttaattagt acataggcta aaagcaagct gtgactgggt tataattttt
     7441 ggagatgtct aatgagatca ataaagaagt taaaaaaacc tgagggctct cttggatttg
     7501 gtgggtaaaa tgtattctaa gatacattcc tcctagcgag ggagtggaac gaaccacaaa
     7561 gacacaaagg acacaaagat tgatcgatcc tatgtaagtt aaacttatca cacagaacct
     7621 agaagagcca cctgagttcg ggttaagcag attgaggtaa agcccagtcc gtcggtcagg
     7681 agagcttctt cggagcgggt caaacttgca gaacaaaaag actacctagc gatcgcctaa
     7741 ttaatagtga tcgacgaatt ggtagcgatc accaataaag aggacacctg aaccaacaag
     7801 tttgacctgc tcccagacgc ggtctcgcca aacgagcgcc taaggcagcg cctgttaacc
     7861 aatgggttca gaatccagag ttggcaaagg ttttgccaca gttccatcag atagccttat
     7921 cccgaactca gattatatta ctctttctga gttttttgat tgttagagtc ctgaatttat
     7981 ctgaactttt cccgattggc aagccttttg accgaggtta ctattgtcag tgtgaatcaa
     8041 gaaaagattg aatcacccac agacttaagg agaacacagt catgagtcaa ccagatgtcg
     8101 aaagatttta tgaaattgcg cgcaatagcg aagagcttca agctatgtta ggcgcggctg
     8161 aagatcgcga cagctttgtc gaaaccgccg tcagactagg acaagagaat ggctgcaact
     8221 tcactcttga cgaagcgaat gagtttctta acaccaagaa gggagatgcg gaactgagcg
     8281 aacaagagtt agaagctgta gctggcggtc gccgccgttg taacttaaat acacgactca
     8341 ctgtctgtat cattgttagc cgcaactgct gggttgctac ttgttaaaat cagctttctg
     8401 gaaacctcga aaaatacctt gctgaaaaag atcaacactt tttatgggtg ctttcttggc
     8461 aataagtgca attaatcgag gtttccttta ttagggtaat accaaatccg cttttcaaag
     8521 tagcgtttct gtagaggagc aaggagaaca cagtcatgag tcaaccagat gtcgaaagat
     8581 tttatgaaat tgtgcgcaat agcgaagagc ttcaagctat gttaggcgcg gctgaagatc
     8641 gcgacagctt tgtcgaaacc gccgtcagac taggacaaga gaatggctgc aacttcactc
     8701 ttgacgaagc gaatgagttt cttaacacca agaagggaga tgcggaactg agcgaacaag
     8761 agttagaagc tgtagctggc ggtcgccgcg gttgtaacaa cacgataatc atttgtagaa
     8821 tcacgtatac aagggaatga gccaccccta gcataaatga gatgctcccg tctgtatcat
     8881 tgttagcaat cttacagatg ctacttgtta gaatccggtt tctgaaaacc tcgaaaaata
     8941 ccttgctgaa aaagatcaac acttttggtg ctttcttggc aataggtaca gttaatcgag
     9001 gtttccctta ttggtctaat accaaatccg cttttaattt ttatcagacc gaagattaac
     9061 attgtatgca acagaatggt taattattca ttaactgaat tgaaggggtt ggcttggctt
     9121 caatatttgg aaatgacctt tccctcttat caaactgctt tacaaagttt gcagtttgaa
     9181 gactctcttg ttgccattgg cgcaagtgtt gagcaaaaac cagttggctt aggtctggct
     9241 aggctttacc ctgaagaaga agcagctatc atcctctcca tctttgttga atccccctat
     9301 cgttgtcagg ggattggcac agccttactc gcgcatttag agcaggtgtt taagcaacga
     9361 ggttgtcggt atgttgaatt agtttataca agcgaccaaa cgacaactcc gtctttagaa
     9421 catatactga aaaaagcagg ttggacaccg ccagagttac gggtgttaat ttgtaaggcg
     9481 atcaaagagc agatgattca agcatcctgg ctacacaaat atagtttacc tgctggtttt
     9541 acaatctttc cttggtctga tttaacggaa gcagaacgaa gtagaatttt agaaaaacaa
     9601 aatactcagg cgtggtatcc agaagttctt tcaccttttt tagaggaaga caaaagcgag
     9661 ccactcaaca gtttaggact tcgttatcaa aaagaagtca tcggctggat gataacccat
     9721 cgtcttgcac cagatacaat ccgctacagt agcttttttg tcaagaaaga gctacaaaag
     9781 gtcgggcgtg gcattccttt attagccgag tcgattaaaa tccagtgtag tagccatatc
     9841 ccctacggaa tgtggacagt atccaaggat aatccagcca tgttgagttt tgttaaacgg
     9901 cgaatggcaa gctatatgat gtcaattaaa gaatctagag gtgtttctaa agtgttatag
     9961 taagttatct gatgaaaatt aaaagaagga ggcttttttt gtgagcgcaa tcccatctga
    10021 tttaaaacca gaattagcca agatcgtctg tcaagctacg tttatttctg aacgtctcag
    10081 tcatcaaaca acatcgacta tctcaagccc atttaatgaa gagatagcaa atattcgttt
    10141 gaatcattgg tgtaaagtca gtgcctctgg agattgggat aaattttaca aacgtctaga
    10201 gtggaatggt tgggaacgcg atgcagtttt gcgagtactt ggtacagagt tagaacctga
    10261 aacttactcc ttacccagtt gggctttaac cctagctgag attatagaaa cagttgcaca
    10321 attaacccaa gaaaatctcg aacccttgcc cagagattct aatgacccta aaccctttga
    10381 agatgttttt ttacctttgg ttctggttgg aagacaaaaa cttcttgctc gcttaggagt
    10441 agaatcatta tctgacgaaa atttgccttt aaaacgattg gaagaatctg cttatctaag
    10501 tctagaagat ggtctttacc aaagactttt ttatctttta gtaaaaactt tagattttga
    10561 gttttctcat tctcgtcccc tcgggaaaaa cttgctcaat ttaataattc cgaacaataa
    10621 aactacatca ggtaacaaaa aatatctagc ttttgttgat aaattattat cagatggatt
    10681 cttggggttt tttcaaaaat atcccgtatt aggtaggttt attgcaacca ctattgattt
    10741 ttgggttgag tcaacggcag aatttctaga aagactggaa aatgatttat tagaaattaa
    10801 gggagaattt tcccagataa atgattcgat tgattctaaa atatcagaaa atcagctagg
    10861 aaaaattaaa gaaattaagc cggacttgtc tgatcttcat catcaaggac gttctgtgat
    10921 cgtgctaact tttgcctcgg ggctaaagtt agtttataaa ccgaaaaaaa taggggttga
    10981 catagctttt aaccaacttt tatcttggtt aaatcaacaa ttagaaaact tagaaagttc
    11041 tgcacaatct cccctgaaaa ttcttcggat tttagataaa caaacctatg gatggagcga
    11101 atacattgaa caaaaacctt gtcaagatac cgccgctgct aaacgttttt atttacaggc
    11161 gggaagattg ttatgtttgt tatattttct aggagcaaat gattttcacc acgagaattt
    11221 aattgcctac ggcgatcaac tggtgatgat tgatctagaa acaatcatgc accatgaagc
    11281 taaatggatg gaagattcgg aagatgaaac agccggagaa gcagcgatga atcaattgtc
    11341 tgattcagtc ttacgcacgg cattgttacc gacttgggag tttaatatcg acacttctgt
    11401 cgcttatgat gttagtggat tgggtagtat tgatattcaa cctatgccgg taccatttcc
    11461 tgtctggaaa tcgatcaaca ccgacgatat gtatttagca caggagaaaa tagatagacc
    11521 tctgcaagct aatgttccta tgcttaattc acagccactt tacccgaatg attatctaaa
    11581 agaattgatt acaggcttcg aacaagtata ccgtttcttg attgaacaga aggaaaacct
    11641 attagcagca aatggacctt tatcgccatt ccagacacag gtagtcagat ttctgttccg
    11701 ttccaccaaa gtttatgggg ctgttctcaa taagacgcga ggggcagaat ttctcaaaca
    11761 tggactagag tggagtattg aagcagatat cttgagccgg gcttttctca ataaccaaaa
    11821 taaacctcaa gcttggccta ttctagagat ggaacttcaa gccatctcct taggagatgt
    11881 tccctatttt agtgctgcta cggtaagcga tgacctcaac ttaggtggtg aacagactat
    11941 accggagtat tttaaaggat catgttttaa tcaagttgaa caacgattaa aacggatgaa
    12001 tgaaactgac ttagctcaac aatctagaat tattcagttg gcctttcagt caaaaattac
    12061 tggaagtttc tcctcagaaa gaagcaaaat tgagtctaaa aatcaggaag aaattactaa
    12121 gactctgttg actggcgacc agtttgttac caaagcaata gagattgctc aagaaatcga
    12181 agaccaggga attattggtt ctgatggtag tctttcttgg attagtttag cttttgttcc
    12241 gaaagcagag agatttcagc tacaaccttt gggagaaagt ttctatgatg gcaattgcgg
    12301 tgttgctgtc ttttttgcag ccttagcccg tgtgacaggg gacagtaaat ttgagaagtt
    12361 aagccttaat tctcttcaat ctttacaaag cttcttacaa aatgcggatg ctgaggcaat
    12421 caaaattttt gccgataact ttggcattgg cggcggagta ggactaggtg cgattattta
    12481 ttgtctcgtc aaaatccgac aatttctcga tttaccccat ctctctcaag aagcacaaaa
    12541 agttgctcaa tttatgagcc aagagattat tgataaagat actaatttcg atatagttaa
    12601 gggtgctgct gggacagttt tatccctttt agctctttat caggatacgg ggacaaattt
    12661 tgttttggat aaggctcaag cctgtggtca acatctgctg aaattttgtg atttgcgcta
    12721 taacgagaaa tcagatacct ataaaccatt gactggcttc tctcatgggg ccgccggaat
    12781 tgcctatgca cttttacgac tctatgaggt gactcaagac caggcttatt caaggggcgc
    12841 acaacaggcg atcgcctatg aaaatagcaa atttttccaa gaatttggta attggcgcca
    12901 aatcatcccc actgaggagc cttctgctgc accagtgttt tggtcaactt ggtgctatgg
    12961 agcgcctggt attggtttag gacgtttagg cggtttatca agctatagaa ctgaagaaat
    13021 tctcgctaat attgaagcgg ctctcaagac aactcaagag actcccttgc aggaagtgga
    13081 tcatttatgc tgtggcaatt taggtcgctg tgaagttatg tgggttgctg cacataaact
    13141 gtctaatccg caatggtaca gtgctgctca agaattagca agtcgagtag tcaatcgagc
    13201 ttctcaaaca ggcaaatatc aactgtttgc tgatttgccg acatccgtgt ttaatccctg
    13261 tttctttcag ggtttgtctg gtattggcta ccaatttctt cgcctggctc atcctgagtc
    13321 tttaccttct gtattactat gggagtgagc agtctatctt aatagggagg aattaaatta
    13381 atcatgccga ctaactttaa ttctaatgaa gcaatcagct atagtgttgc cttagtcatc
    13441 attggcttgg taatattact cggcttatgg ttgccagatt ttttacataa agattgagag
    13501 cgtaatatat cgctcttctg ggactttcgg aaatccctga ccgaatctag gttctgaaac
    13561 tcttggttga caagcgaacg ctaacttttt ttctaataaa aactcaaatt tcgggtttct
    13621 gttagttagc actcgtttga aggcttaccc ataagagagc tagagttgag agactgtaag
    13681 atttttgcca gagttccaga agagcgttat actaaatccg ttgagtatag gctagttatg
    13741 aggagagaca aaaggtttcg gccgtgagct tagccgaacg gcaagaggca ctcatgcaaa
    13801 ggggagaata aataatcatt ctttaataac cagatttagt attaatcata aagtgcagaa
    13861 tgtggtatat aatatctgtt gaaaaaccaa aacaataact aaaaatgatg ctaagagaaa
    13921 ttttagtcaa ctctttaata ttgagcttga gtttgataga ggtagagttg gcggaagcaa
    13981 atcctttgca aacaagtttt tcaaaccgat ttcccgatgt atcttcaatt aaagatagca
    14041 gtagagaaac tacctttaaa ccaaaaatat tgcagcaaaa acaaaattat cttgaaacaa
    14101 actcgaaaaa aattagtaat gatattgtag aaattccaat ggagaaacaa aatcagagtt
    14161 ttccctccga gctaaattcc aaccctaacc ccttgctttt gccaactgaa caagacataa
    14221 agcaaagtca agaacattta atagccatta ctttagaaca agcaatcgaa ctagcaaagc
    14281 gcaacaatca gcaattaaaa atagccatcc tccaattaga atcaagtcgt gctgggttag
    14341 cagaagcaac agctgctctg tatcctactt tatcactttc cacaacagca acgcgggcat
    14401 tatcggctag tggtgaactt gccgctcagg caaacgaaaa acagcaaatc gccaccctca
    14461 atggttttga aacacagcta caaaatagcc aagcacttgt taatttcctg caagggcggg
    14521 ttaatgccaa gcaagaggaa ttagaccaaa ttaacaacat tattgtaccc tctcccccca
    14581 ccgatatagc tcccgattta gcgcaacaaa tagaagctct aagtcctttt tttgtcccgc
    14641 aatcagccgt aactcaattc gccggacaga cccaaatcaa aaaaagcatt gagctagaat
    14701 ttttaacgag ggatttgcaa caagctcaaa gttcattaca gtcacagcag gagcagattg
    14761 catcgacgca acaaagtatt gcccaaatta gtaattttgt tacaacaaca gtagatggga
    14821 aactctcctt atcttataac atctattctc ccggcagaca ggctaacatt aactcggcta
    14881 aagaaactct gaaaattaat gaattggaag taacgaggat agaagatcaa ttaatcctag
    14941 atgtagctct tgcttattac gatttacaac aagccgatgc ccaggtgttg attttccaga
    15001 acgatattaa tgaccgaacc aaaagacttg aaagcataga attaatgctc aatgttggtt
    15061 tagctactaa gttggattta ctgaatgccc aagtcgattt agataatgcc attcaggaac
    15121 tgcgtaataa tcaagcaatt caagaaacaa cccgtcgaaa tttagcaact atcttgaatt
    15181 tgcccgcctc gataaccccg atagcgggcg atcccgtcag tcaaactgga gtatggcagt
    15241 tgcctttaga taaaactatt ctcttagctt ttaaaaaacg cgtggagcta gagcaaaggt
    15301 tagccgaacg tcaacgtagc ggcgcccagc aacagttagc cttagctgtt atcagaccaa
    15361 gtctcagtat ttttgctgaa tataatatat tatctcttag cagtgaagat ccaaatcgct
    15421 ttaccccaaa gggaactgag gatggctatg cttttggttt aaactttaac tggctttttt
    15481 ttgatggggg agccgcaacc tctagagcga aacaagccgc cacagggatg gcaatcgccg
    15541 agcagcagta ttcggaaaca gcgaataaca ttcgcctaga agtagaaagg gcctattatc
    15601 agctacaacc ccaattaagg aatattgaga cggctactca aagtatcaag cgagcggaag
    15661 aggcacttaa agcagccgaa atccgttttg atcttggggt taatacccaa acggaagtac
    15721 tcgatgcacg aaatcgttta gttcgggctc agaacaattt aattaatgcc attattactt
    15781 ataatcgttc atttgctcaa ctacaacgag ccgcgggctt cagacttggg gaaaattagc
    15841 tgaaaaaagt ggtttttcgt tacttggtat ggttcgatag gggggcataa atcgactaaa
    15901 tccttatctg gtaagagact taattgatta gttcgctcta tatcaaaaac aattgacaaa
    15961 aatcgctaaa tgcctttcta tataagggtt ccatccctta taacccccgt ccattgcata
    16021 acacaaaccg aagagccaaa aaagtgacta aaatccaaat aatctagtcc tgagcatctc
    16081 aacttcgagt taaatatttg gcatgaattc ttaaagtcct gaaaaaacct gaacttttct
    16141 gtcttgacac agaccgttat cgtagctaat ctgctaatta aataattatc tatgcaggaa
    16201 aaatctatgt cacctattcc cttgttaatt atggaagaac accacgaagc attttttatt
    16261 tggaactatg cggtcttaaa cggatggatt ccacccaaaa aaaacctttt acttcatgtt
    16321 gatgaacatt cggactttgg tactcctaat ctatcccact ctcttaactc actcaatggt
    16381 gacttagaaa atatttataa ctttacttat acagaattgg gaattgcaga ttttattgtt
    16441 cctagtattt atcaggggat ttttaatgaa ctttattggt taagacaaac tcataacgct
    16501 gaacaaaccg aggtcatgaa tcatgttttt tctttaaatg cggaaggaaa aattttattt
    16561 gtaaccgaag atgtcaacaa ggcgggactc tttaatctcg atagaaaacc tttaaaaaat
    16621 aaattaatca cgacgacaga ttcccttgtc aatcaagaaa aaactgtcgt tgtggatatc
    16681 gatctagact atttttcttg cgataaccaa gcgggagagg ttttggaaat agaagtgagt
    16741 aaagaaacct atgaatcttt cttaaataat ccctacgatc cgattcggat taagctgggt
    16801 ggaacggcta aaatgaaaga gaaaaatggt aaatcttact tttttatgca gcgacctgtt
    16861 atggaatctt ttctcgaaaa agaccgagca ttaaaagttt cgcaagcaga aattcttgaa
    16921 agaatcgata agtttagcac ctttctcatt gacaataaaa tccagcctaa attaattgat
    16981 atttgtcgtt cgagattgag tggatatacc ccagacgatc aatggcaatt tattgaatct
    17041 aatttaatcg aaaaactcca gggtatttat ccagtagaag taaaatctat ccaagatatt
    17101 ttatcggtta aaacttagcg attttgcaac tcataagcac tgtcaatcga tcgctcctaa
    17161 aagttttaga gtattttttt gagcttcggt caatccccga accatagtaa tgctcatccc
    17221 ttcatagggg cgttcagttc tgatcgtctt acaacatcga ccggttttca tatcccaaag
    17281 tttaatcgtt tcatcttgtc ccccactggc aagcaattgc ccatcagggc taaaagcaac
    17341 cgataaaacc cactgtttat ggcctgttaa ggttgttagg tctcgacctg aaggcatctc
    17401 ccaaagctta atggttcgat cgcaactacc acttgctaaa atgtcgcctt gaggattaaa
    17461 ggcaatggtc tgaatccaac tatcgtgacc ttgaagggtt gctaaacatt tcccgctttg
    17521 gacattccat agtttaatct tagagtcaca agaactactg ctgatcagat taccttctgg
    17581 actaaaggcc accgccaaaa cccagctacc gtgtcccgta aaagtcgtca aacattcccc
    17641 tgtttcaact tcccacaatt ttactgtttt gtcttcactg ccactaacaa gagtaagtcc
    17701 atcgggactg aactggatcg accataaaca gcctgtgtga ccatgtaacg tttttctaca
    17761 atgacctgtg gtaatatccc aaagtttaat cgttgcatca ccactacaac tagctagggt
    17821 caacccatct gggctaaatg taatcgtccg aatccagcga gtatgtccta ataaagtttt
    17881 taaacactgg ccagtcttag tatcccataa tctaacacta taatcactgc tcccagtagc
    17941 tagcaaagtt ccatctggac tgtaagcgat agaactgatc catcctttat gtccttctaa
    18001 cttcgaccat tggtcagtct caattttcca tagtctaaca gttcgtgttt caccactagc
    18061 cagtgtcttg ccatcaggac taaaggctac tgattgaatc caactaccat atccttgcca
    18121 agttttccaa cattggcctg tgttaacctc ccaaaacctg atggctcgat cttctccccc
    18181 actcactaaa atagcaccgt ctgaactaaa tagcactgaa gttagacgat tattatggcc
    18241 atggatggtt ttgagacatt tcccttcttc tacatcccag attctaatgg tgtgatctcc
    18301 tgccccactg gccagcaagt ttccttgagg actaaaagcc actgaacgta ttcgctccgt
    18361 atgaccttca agtgtaaaga tacaccgtcc ttggttaata tcccaaattt taactgtatg
    18421 atcgccacta ccactggcta aacgctgacc atctggacta aatgcgacat atcgaaccca
    18481 ttggcgatgt ccactaaatg tttgcaaaca ctgacctgtt tctgtatccc acaacttgag
    18541 agtatggtct tcgctaccgc taacaatcat tttgccgttt ttactaaaag cgattgacca
    18601 aacagtgttt tcatgtccgt tcagagtttg taaacattct ccagtatcca cacttcggag
    18661 agtaatattg tagtcattgc caccactggc taagattttt ccgtcggggc tgaaagcaac
    18721 cgtatagatg cggcaattat ttcctaaaaa ggtgtataaa caactaccat cctcaacaga
    18781 ccataatttc accgtctgat cactactagc actgctgagc atttttccat ctggactaaa
    18841 ggcaactgcg tgaacccatt ctgtgtgtcc tttacaactt aataaaagtt gattatctgc
    18901 cacttgccag aaatgaatct caccgttgac atctcctgtg gcaagaattt gtccatcagg
    18961 gcttaaagca attgataaaa tattggttat ttgtttggca aatacgcatt tactcaaatc
    19021 ggaataagcc aaattaactt gatgtaaatg tgtatcttga agataactag accaaagact
    19081 aagataggag aagtcataac cagttaggtc aatattaaga tagccaaaaa tattaatgat
    19141 attaccggct aaatatccca gtttttgagg attatgttct tgccaggtga ggagaatttc
    19201 cttgagtcgc tcaacaagtt tttcttcagt ataataaata cacaacaagt tttcaataag
    19261 aggtttgatt gttaatttta tctgtaattt cctgatatgt tcttttccat taatattgag
    19321 aaaggcatag caattaagaa gatttatttc tcccgttgtt atctcgctag taatccgatt
    19381 tataaatcga taaattaaat actctctaat ggacggatgt aagaagaact tgttttgata
    19441 cttttcaatt agacatctct gaattaaaga ttttaatttt attagtaaat tttgttgaga
    19501 aataggaaaa atttctgctt ttaaatcatc gatcgataaa gattgttgac tcaaagctat
    19561 acagtaaaga atattttgct ctaaatcaga taatctaata aactgttcct caaataaatt
    19621 agatatttca tcaacaaaaa aactttgctc ttgtaaaaaa ctactaatat cgcaattaaa
    19681 taaatcttta atgattccac aaactaattt aagaataaga ggatttctac catatttttc
    19741 aatcaagata agggaatcag attcagattt actttcgcat ccttttagct gaattaactt
    19801 aaggctggct gagacactta atccgtttaa ctgtaaagag cgaactggca aagtttcccc
    19861 ttgcattaaa gaaacttctt tttgtttttc tctactggtt attactaaag tgctttgatg
    19921 ggaactttcg cctattcgtt tgaagaaatt tccatattct tgaaaaccat cttgataaga
    19981 tcctacttgg actccactgg acataattga ttcacaatta tctaaaatga tcagacagcg
    20041 ttgttgtctg aaatgctcaa ttaataggga aatttggtca tcaacactta ctaaaacttt
    20101 gttttcttga tcttgactga taattgacaa aatatcaagt agaagttttc ttattgacat
    20161 aacttgactc aaggaacgcc aaataaccca atcaaaatcg ccctgaattt gcttggctaa
    20221 ctgaattgag agataggttt ttccaatgcc agctattcca aatagtgcaa ctaaacgaac
    20281 ccgttctcta ataatccatt gtttaagagt ggcaatttct tcttgacgat cataaaatac
    20341 cgatatttct ggggcttcac cccaatcttg ccctaatttt gactgcgata gggtataagt
    20401 ctgtaaaatt ggcttgtacg agtctttaat tgggttaata ccagaaaagt ttttagcctt
    20461 atgtctttct aaaacagccc gaaaattgct ttttttgact ttttcgccac aggcttcaga
    20521 caggcgattc catagtttgg gacctacatc ttgtttaatg taattgggcg aatatctgta
    20581 agtcttagca atttcttcat aggaaagccg attttcagtc cacgatgcct gaaaaattaa
    20641 ccgttcaaga tcgctcaaat gttggccaga gtgattaaaa actatgttct cagccaaagc
    20701 catggcttct tcaagattca taagctattt ccccttaaaa aggtgagtaa ggacttgttt
    20761 agctaaaaaa gtgtcagcaa caaaagacct ctccataata ttatcttaag accaaaagtc
    20821 tttgtagtta aggaatctac ccgaataaaa attattttaa ttgcctcata ttttttcagt
    20881 gaaattgaat tagcaacgat agatatacat ttcaggcatc gaactattta gttagtacgc
    20941 agactaaaag caagctgtga ctaggttata atttttggag atgtctaaac attgataaat
    21001 caaaataggg actcatacta aatccgttga gtacaggcta gttatgagga gaggcactca
    21061 tgcgacaggc aaaagggaaa ataaataatc agtttttaat aaccagattt agtatgacaa
    21121 taggctaaaa taacggtact tttcagcatt gtagcgacga ttcctagttc tgaccgcact
    21181 tttccagaaa aatttacaat tattcaacgc aattaatggt ctgtcacaat atcaacccat
    21241 tacccagtag tttccccagt ggtttcagga gcggaaaacc ccgtcaagga tagaagttgt
    21301 cgtttggcgg tttcccgttc ggctcttctg gtttctgtgt ggaaacgggg tctatactga
    21361 tagaatatcc gcaaaatagt cctaaaagtc ttgcccagta agcatttcac gattccataa
    21421 gcaaaaatta tcacacaaag tcgagaagag cccccgttcg agacggtaac ggttcaactg
    21481 aatctctaac tgttctcgtt gggcgattct tgttagatag gtttcggtgg atgaaccgcc
    21541 cagacgataa tcaatctcgg taatccgggt caagaggtcg tgattggaca gttgggctaa
    21601 tatcgcccgt tctcgatcgc cggcggtttc ataaccgatc accagcgtca agacctgttc
    21661 tcccagttga gagcgtttgg cagcccgttg acgttccaat tcagccttgg ccgcctctag
    21721 gtcggccgcc ctgatttcga ggtcggtgat ggctatcctt tgttgttgta cctgaccacc
    21781 cccaaacaga ttttgcagaa tggcgatcgg gtcggtggtg agataacccg tccattgtcg
    21841 ggcgttggcc tggtcgatac gttgtccagc caactgtaac cggcgatcga tcagggcgat
    21901 gcgctcgtcg aggatctgca attcagggga acgttcgatc gccgcttcgg taagggtacg
    21961 gagacaatcg ttaccgctat cgagacaggg aagcggagcg gcctgtaggg gagtcaaccc
    22021 ttcggcttcg ctcagggtta accctttggt ttcgctcagg gttaaccctt tggtttcgct
    22081 cagggtcaac atcaacagta agctcgacag tgagaaggcg atcatcctga ccctgccatt
    22141 taagccgttt gaccgttccg gggtagggag ccttaaccgt agccaattga accagtgcat
    22201 cgtcgatctc ctgtattctc gtcctgatca ccgctttgtt gtattctcgt tcctgaagtt
    22261 gtgcggcgcg aactgccctc tgtttctcca cttccagttg ttggttctga agggtgatcg
    22321 cccgtcggtt ttcttctagc ccacattccg caccctcaac tgtcacataa gctgtccccc
    22381 tccagagact tgagtaaaaa tacttagctg gtgaaggttt tctcggtggc cgttaggggg
    22441 agcttgagac ccctaattat gaaaaaatag gaattgttgg aaaactgagg cgagtggact
    22501 gttcgaccat gaatcaatca acagaaattg aagtcaaaaa tctagaccat ctgggattag
    22561 tagccggaat tatcgatgaa ataggaatcg ttgaaattat caacgaacaa gtctcaattg
    22621 agcgaggaga aattgtcaca gcggggcaag tcgtgaaagc aattatcctg aacggattgg
    22681 gatttgtctc ccgagccttg tatttatttc ctcaattttt tgaagataaa gcaaccgaac
    22741 atctgctggg agaaggcatc gaagcaaaac acctgaatga tgataaaatt ggtcgagtaa
    22801 tggacaaact ttatcaactt aatgtttcgg tcattttcct actcattagt ttagccgccg
    22861 tcaaaaaatt tggtgtagca accgagaatt cccatttaga ttcgacttct ctatcagtag
    22921 aaggagaata taacaaggaa tacccaacag tagaaatcct gaaatcagga gcagtgggag
    22981 aagaaattga aaccagacaa cagccaataa aaattaccta cggatactcc cgcgaccgac
    23041 gacctgactt aaaacaattt atgattgact taatcgtaag tggggatgga gatgtacctt
    23101 tattcctgaa agtaggggac ggaaatgaag cggacaaagc ggtttttggt caaatcgccc
    23161 gagaatttca aaaacaagtt gactttgaca gtttaatagt cggcgatagc gccctctata
    23221 gcaaagagaa tttaaaacta atgagagaaa tgcgttggtt atctcgagtc cccttcagca
    23281 ttaaagaggc tcaagagtta gtcgatagca tctcagaaaa agagttaacc gatgcagaaa
    23341 taccgggt
//
