LOCUS       NZ_AP024565            22298 bp    DNA     circular CON 26-SEP-2024
DEFINITION  Microcystis aeruginosa strain NIES-88 chromosome, complete genome.
ACCESSION   NZ_AP024565
VERSION     NZ_AP024565.1
KEYWORDS    RefSeq.
SOURCE      Microcystis aeruginosa
  ORGANISM  Microcystis aeruginosa
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Chroococcales; Microcystaceae; Microcystis.
REFERENCE   1
  AUTHORS   Phan,C.-S., Matsuda,K., Balloo,N., Wakimoto,T. and Okino,T.
  TITLE     Argicyclamide A-C unveil enzymatic basis for guanidine
            bis-prenylation
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5478552)
  AUTHORS   Matsuda,K. and Wakimoto,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2021) Contact:Kenichi Matsuda Hokkaido University,
            Graduate school of phrmaceutical sciences; Kita 12, Nishi 6,
            Kita-ku, Sapporo, Hokkaido 060-0812, Japan URL
            :https://www.pharm.hokudai.ac.jp/tennen/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Coverage                   :: 87x
            Sequencing Technology             :: DNBSEQ; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019704275.1-RS_2024_09_26
            Annotation Date                   :: 09/26/2024 11:16:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,602
            CDSs (total)                      :: 5,550
            Genes (coding)                    :: 5,071
            CDSs (with protein)               :: 5,071
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 479
            CDSs (without protein)            :: 479
            Pseudo Genes (ambiguous residues) :: 0 of 479
            Pseudo Genes (frameshifted)       :: 110 of 479
            Pseudo Genes (incomplete)         :: 380 of 479
            Pseudo Genes (internal stop)      :: 101 of 479
            Pseudo Genes (multiple problems)  :: 91 of 479
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:54:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 218376
            Orig. end                         :: 240674
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024565.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22298
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..22298
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22298
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12298](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12298)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            54..1130
                     /locus_tag="LC603172_RS01080"
                     /old_locus_tag="MAN88_02140"
     CDS             54..1130
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002767435.1"
                     /locus_tag="LC603172_RS01080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02140"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_061432072.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 5.2e-06,
                     bitscore: 24.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILLFSRYDTLGASSRYRTYQYLPYFKKEGIEVETAPLLDNDYL
                     RTRYLGKKYPLSRLLSAYQQRISLLLQSQKYDLIWLEKEALPWLPAWLELLLLRGRTPY
                     VVDYDDAVFHRYDQHSAPIVRWLLAQKIDRVMQNARLVIAGNDYLANRATQAGAKWVEI
                     LPTVVDLDRYPLSKAPQNEVFTIGWIGSPLKFVDYIQELYPVLKEICRDGGAKVVAIGA
                     KETNLEDIPLEIKPWSQATEVKEMQQFDVGIMPLTDTAFERGKCGFKLIQYMASTRAVI
                     GSPVGVNAEIIKEGINGFQASSQAEWLQAFQNLKNDRDLRESMGWAGRKLVEDKYNIQI
                     TAPKMLQLLQKANQVLKT"
     gene            1182..2300
                     /locus_tag="LC603172_RS01085"
                     /old_locus_tag="MAN88_02150"
     CDS             1182..2300
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004160837.1"
                     /locus_tag="LC603172_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02150"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_061432071.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.4e-39,
                     bitscore: 133.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILFIITRADTVGGAQVHVRDLARFLQDSHHQVLVVTGIKGIYN
                     DDLISHRITNISCQDFGKKINLIQDWQTLNFIKQIIAEFQPDIISTHSSKAGILGRLAV
                     RKSKTPCIFTAHGWAFTGGVPEPSRTIYQWLETITEPLANKIICVSEQDRLIGIKTGMQ
                     PQRLLTIHNGMPDLPAELRANPGNANPVRIVMVARFDQQKDHVTLLKAFQNIPEAHLDL
                     VGDGPDLEKIKTLAKELKIIDRVNFLGFRNNVAEVLAQAQVFTLISNWEGFPRTTIEAM
                     RAGLPVIVSDVGGASEAIVEGITGYTVARGDVNTLHQRLLQLVLDQQFRAKMGAAGRKR
                     YETEYTFEKMFEKTFQVYEQVLAERRKNDDRE"
     gene            2284..3186
                     /locus_tag="LC603172_RS01090"
                     /old_locus_tag="MAN88_02160"
     CDS             2284..3186
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002767439.1"
                     /locus_tag="LC603172_RS01090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02160"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_239698116.1"
                     /transl_table=11
                     /translation="MMIENKILITGATGLPGGFFMQHLASTKPEIEIHCLIRPSSDRSM
                     LDSLGLNLTYDFGDSSISETWEGIFRENSFETIIHLVQLRQVPTILNSLKKFQQTPRLI
                     IIGTTGVYSKYNEYSAEYKQAENYLQEYPASYCLLRPTMIYGTPKDKNLHKLIKFCHRY
                     GFFPIFGSGDNLLQPVHADDIAQMLLKVWECPDIKGAYDLSGGSIVSFRQLILLIEQLL
                     GQSVRPLSFPLNFGIWSATLLEKTLAKKSPVRREQILRLQEDKAYSHEEAKRDLGFTPR
                     TLEAGLQQEIELMRSQGII"
     gene            3332..3484
                     /locus_tag="LC603172_RS27610"
     CDS             3332..3484
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS27610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_239698115.1"
                     /transl_table=11
                     /translation="MGITPLLPGRLVYNQLEEAKNFYLALGFDVSPLEPMTLMITLNDL
                     RARIA"
     gene            complement(3672..3848)
                     /locus_tag="LC603172_RS01100"
                     /old_locus_tag="MAN88_02170"
     CDS             complement(3672..3848)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MAN88_02170"
                     /product="hypothetical protein"
                     /protein_id="WP_221275454.1"
                     /transl_table=11
                     /translation="MTVEGAECGLRVAKVIVPGMRHMWKRLGLGRLYDVPVKMGWLKEA
                     LTEDELNPFPLWM"
     gene            3991..5649
                     /locus_tag="LC603172_RS01105"
                     /old_locus_tag="MAN88_02180"
     CDS             3991..5649
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012264372.1"
                     /locus_tag="LC603172_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02180"
                     /product="IS1634 family transposase"
                     /protein_id="WP_221275368.1"
                     /transl_table=11
                     /translation="MNQSTEIEVKNLDHLGLVAGIIDEIGIVEIINEQVSIERGEIVTA
                     GQVVKAIILNGLGFVSRALYLFPQFFEDKATEHLLGEGIEAKHLNDDKIGRVMDKLYQL
                     NVSVIFLLISLAAVKKFGVATENSHLDSTSLSVEGEYNKEYPTVEILKSGAVGEEIETR
                     QQPIKITYGYSRDRRPDLKQFMIDLIVSGDGDVPLFLKVGDGNEADKAVFGQIAREFQK
                     QVDFDSLIVGDSALYSKENLKLMREMRWLSRVPFSIKEAQELVDSISEKELTDAEIPGY
                     SWRETISNYGGIEQRWLLVESQTRKESDLKKLEKKIEQEKNSAQEKIRQLSRREFENRA
                     VALAIVKGLSDSLKYHQLTEIKVNLIPPESQQSKLKSKDDLSSQSYQVQAELELNLAAI
                     ERLKKRAGRFVLATNDLEKKRLSSEDILKKYKGQQAPERGFSFLKDPCFFADSVFLKSP
                     HRIEVLAMLMGLCLLVYTIGQRQLRLNLKQQETGLKNPLGKLTDRPTLRWIFQNFQGIH
                     LLRIQDNQKISNLTDERRNILRFFPKPCQEYYLLS"
     gene            6235..7563
                     /locus_tag="LC603172_RS01110"
                     /old_locus_tag="MAN88_02200"
     CDS             6235..7563
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002768410.1"
                     /locus_tag="LC603172_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02200"
                     /product="hypothetical protein"
                     /protein_id="WP_052275264.1"
                     /transl_table=11
                     /translation="MEVQDLSFIGMLSYFHRAIAGMVDPRSASNATRYSLKDAVLGAFA
                     SFFMQNESFLEYQRQLNSRCGRDNAQSLFGLVNIPTIEQIKNILDRIAAKPLFSPFKWI
                     YQGLREQGYLRLFTALDGNLLVALDGTQYYDSEKISCPCCSTRTSKQGKVTYHHQAILP
                     VIVSPDQKSVISLPPEFITPQDGSEKQDCEQNAAKRWIASHASWFEGQPITLLGDDLYS
                     RQPMAEYCLEHHFNFIFVCLPSSHPTLYEWVSFLEANQEVKTTQQRRWNGRYFEIWDYR
                     YLNQVPLREQQPALLVNWCEVTVKRESDGQLLYRNSWITNHDLTPQRVILVCAAGRSRW
                     RTENENHNVLKTRGYHLEHNFGHGQQHLSSFLLTLNLLAFLFHTVLHLVDERYQRARMQ
                     RGTRRGFFNDVLCLTKYLLFEGWHHLLDFMLDEAIPVTRVNSS"
     misc_feature    7681..7695
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     gene            8491..8733
                     /locus_tag="LC603172_RS01115"
                     /old_locus_tag="MAN88_02210"
     CDS             8491..8733
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MAN88_02210"
                     /product="hypothetical protein"
                     /protein_id="WP_061431899.1"
                     /transl_table=11
                     /translation="MTQVIQTGKTLKAGTGKITINFPKPFAQIPVVVVSSFWENVGSQV
                     GNIETIDTISLESFTIVSSNAATNYYVNWIAISQE"
     misc_feature    complement(9000..9014)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            9081..9218
                     /locus_tag="LC603172_RS01120"
                     /old_locus_tag="MAN88_02220"
     CDS             9081..9218
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025088.5"
                     /locus_tag="LC603172_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02220"
                     /product="DUF4160 domain-containing protein"
                     /protein_id="WP_239698113.1"
                     /transl_table=11
                     /translation="MFYEIIVYRYFIDNKQHYIRHINARYQEDEVIVSIPDGEVLEGSS
                     "
     gene            9320..9664
                     /locus_tag="LC603172_RS01125"
                     /old_locus_tag="MAN88_02230"
     CDS             9320..9664
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002798095.1"
                     /locus_tag="LC603172_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02230"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_004163940.1"
                     /transl_table=11
                     /translation="MGDKPIYWIGTSREDIRDFPEDAKRKAGFQLRAIQQGEKPNDFKP
                     IPIIGQGTEEIRIWTGETYRIFYVARFKEAIYVLHAFGKKTQKTSKKEIELGQKRYQQM
                     IQFRQQLQEG"
     gene            9667..9966
                     /locus_tag="LC603172_RS01130"
                     /old_locus_tag="MAN88_02240"
     CDS             9667..9966
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002757640.1"
                     /locus_tag="LC603172_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02240"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002757640.1"
                     /transl_table=11
                     /translation="MTQSNPIEITFGSDNIFEDLGFNSEEATNLKIRADLMLTLRSFIQ
                     EKRWTQQEAATFFEETKPKISDLMNGEISRFTVDKLLSLLDKTGMKVKLEIFTK"
     gene            complement(10001..12298)
                     /locus_tag="LC603172_RS01135"
                     /old_locus_tag="MAN88_02250"
     CDS             complement(10001..12298)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002770323.1"
                     /locus_tag="LC603172_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02250"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_061431900.1"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 3.1e-06, bitscore:
                     25.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 1.1e-08,
                     bitscore: 33.3, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03882 (E-value: 1.2e-55, bitscore:
                     186.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 7.3e-92, bitscore: 306.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.9e-79, bitscore:
                     264.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNQLDWNPAYSIETLEPNTVFFLSERESICFQEPLYYRLVRLID
                     GQRNLDEIIDILQLEFLQNQEINPNNANSFAVIVNYSLAIQKAIFQLYKRGFLLEKQEL
                     LPSNLAILCHHLRVSQAQAFERLQSLKVTVKTLGLIPQQDLINILNSLQVQVADEGDLT
                     IILTDNYLHPDLESINQQALASHKPWLLVNPLGNLAWIGPLFDPDKTGCWHCLAQRLRD
                     NRPVEEFIIRQRENKISLISPLGFSSATIQTVLNLTAMEVFKWIIQGKNQRLEGMLMTY
                     DTLNLQFQEHILVKRPNCPSCGYSLNKTPLPVVLGHRKKGFTNDGGHRFCSPEETLRTY
                     QHLISPITGIVRELNKIQGNTLVHTYVAKHHFRGLFDDLDSLRQNIGGRSAGKGRTDSQ
                     AKASGFCEAIERYSGVFQGNEIREKASYQELGDEAIHPNKCMNFSEKQYQHREEWNAKN
                     QGWFQKVPEPFDETRIIDWTPVWSLTAQDFKYLPTGYCYYGYPQSEPLDCWADSNGCAA
                     GNTIEEAILQGFMELVERDCVALWWYNQLVKPSLNLESFNEPYFEQLKQYYEGLNRELW
                     VLDITSDLNIPCFAAISPRKEREAEDILLGYGAHFDPKIAISRALTEVNQILPNVLSFK
                     DDGTTIYNPSADPLAVKWWQKARLSNQSYLVPDSKIIPKKSNDYLQLASDDLLEDVKLC
                     QRIVESKGMEMLVLDQTRPDIGLRVAKVIVPGMRHMWKRLGAGRLYDVPVSMGWLKEAL
                     TEDELNPFPMWM"
     aSDomain        complement(11966..12292)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC603172_RS01135_NHLP_CD_RRE.1"
                     /evalue="1.60E-08"
                     /identifier="RREFam015.1"
                     /label="LC603172_RS01135"
                     /locus_tag="LC603172_RS01135"
                     /protein_end="111"
                     /protein_start="2"
                     /score="25.5"
                     /tool="antismash"
                     /translation="NQLDWNPAYSIETLEPNTVFFLSERESICFQEPLYYRLVRLIDGQ
                     RNLDEIIDILQLEFLQNQEINPNNANSFAVIVNYSLAIQKAIFQLYKRGFLLEKQELLP
                     SNLAI"
     aSDomain        complement(12125..12289)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC603172_RS01135_Cyanobactin_D_RRE.1"
                     /evalue="5.70E-11"
                     /identifier="RREFam007.1"
                     /label="LC603172_RS01135"
                     /locus_tag="LC603172_RS01135"
                     /protein_end="58"
                     /protein_start="3"
                     /score="33.3"
                     /tool="antismash"
                     /translation="QLDWNPAYSIETLEPNTVFFLSERESICFQEPLYYRLVRLIDGQR
                     NLDEIIDILQ"
     gene            12911..13258
                     /locus_tag="LC603172_RS01140"
                     /old_locus_tag="MAN88_02260"
     CDS             12911..13258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002770325.1"
                     /locus_tag="LC603172_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02260"
                     /product="rubredoxin"
                     /protein_id="WP_002736293.1"
                     /transl_table=11
                     /translation="MSDRPPELTLADQAPANHECRSCGYVYDPSKGDSKTNTPAGTPFE
                     ELPETWRCPVCGVRRSQFINIGAKDAPSGFQENLSYGFGVNRLTPAQKNILIFGALALG
                     FVFFISLYGLN"
     gene            13365..14357
                     /locus_tag="LC603172_RS01145"
                     /old_locus_tag="MAN88_02270"
     CDS             13365..14357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004163934.1"
                     /locus_tag="LC603172_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02270"
                     /product="photosynthesis system II assembly factor Ycf48"
                     /protein_id="WP_061431901.1"
                     /transl_table=11
                     /translation="MRKLKQFVIVLAVAFFCFSCSSVPSLSSSPWQILTLDTDSTFADI
                     AFTDDLQHGWLVGTKSTLFETTDGGDSWQQKVLNLGEEKVSFSAVSFHDQEGWIVGKPS
                     ILLHSEDGGSSWSRIPLSEKLPGSPYGIIALNDKTAEMVTDLGAIYRTKDGGKTWQALV
                     EGAVGVARTIVRSHDGKYVAVSARGNFYSTWEPGSTEWQPHNRLSSRRLQKVGYGEKGE
                     LWALARGGQLQFTSPNDLDTWEDKVFPEFSTSWGLLDLNYRSPEEIWVAGGSGNLLVSH
                     DSGQSWQKDRAVESVPSNLYRIVFINSDKGFVLGQNGVLLKYNPPSESA"
     gene            14436..14681
                     /gene="psbE"
                     /locus_tag="LC603172_RS01150"
                     /old_locus_tag="MAN88_02280"
     CDS             14436..14681
                     /GO_component="GO:0009523 - photosystem II [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0009767 - photosynthetic electron transport
                     chain [Evidence IEA]"
                     /GO_process="GO:0015979 - photosynthesis [Evidence IEA]"
                     /GO_process="GO:0019684 - photosynthesis, light reaction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="psbE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008202359.1"
                     /locus_tag="LC603172_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02280"
                     /product="cytochrome b559 subunit alpha"
                     /protein_id="WP_002749269.1"
                     /transl_table=11
                     /translation="MSGSTGERPFGDIVTSIRYWIIHSITIPMLFIAGWLFVSTGLAYD
                     VFGTPRPDEYYTQERQELPIINDRFEAKNQIEQFNQ"
     gene            14707..14841
                     /gene="psbF"
                     /locus_tag="LC603172_RS01155"
                     /old_locus_tag="MAN88_02290"
     CDS             14707..14841
                     /GO_component="GO:0009523 - photosystem II [Evidence IEA]"
                     /GO_component="GO:0009539 - photosystem II reaction center
                     [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0009767 - photosynthetic electron transport
                     chain [Evidence IEA]"
                     /GO_process="GO:0015979 - photosynthesis [Evidence IEA]"
                     /GO_process="GO:0019684 - photosynthesis, light reaction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="psbF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012598217.1"
                     /locus_tag="LC603172_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02290"
                     /product="cytochrome b559 subunit beta"
                     /protein_id="WP_002736175.1"
                     /transl_table=11
                     /translation="MASGNPNQPISYPIFTVRWLAVHTLAVPTVFFIGAIAAMQFIQR"
     gene            14852..14971
                     /locus_tag="LC603172_RS01160"
                     /old_locus_tag="MAN88_02300"
     CDS             14852..14971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002735805.1"
                     /locus_tag="LC603172_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02300"
                     /product="photosystem II reaction center protein L"
                     /protein_id="WP_002735805.1"
                     /transl_table=11
                     /translation="MERTPNPNRQAVELNRTSLYLGLLLVAVLGILFSSYFFN"
     gene            15014..15133
                     /locus_tag="LC603172_RS01165"
                     /old_locus_tag="MAN88_02310"
     CDS             15014..15133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015785128.1"
                     /locus_tag="LC603172_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02310"
                     /product="photosystem II reaction center protein J"
                     /protein_id="WP_043995402.1"
                     /transl_table=11
                     /translation="MFAEGRIPLWLVATIAGLGVIAVVGLFFYGAYAGLGSSM"
     gene            complement(15807..17333)
                     /gene="psbB"
                     /locus_tag="LC603172_RS01170"
                     /old_locus_tag="MAN88_02320"
     CDS             complement(15807..17333)
                     /GO_component="GO:0009523 - photosystem II [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016168 - chlorophyll binding [Evidence
                     IEA]"
                     /GO_function="GO:0045156 - electron transporter,
                     transferring electrons within the cyclic electron transport
                     pathway of photosynthesis activity [Evidence IEA]"
                     /GO_process="GO:0009772 - photosynthetic electron transport
                     in photosystem II [Evidence IEA]"
                     /GO_process="GO:0015979 - photosynthesis [Evidence IEA]"
                     /codon_start=1
                     /gene="psbB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002735904.1"
                     /locus_tag="LC603172_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02320"
                     /product="photosystem II chlorophyll-binding protein CP47"
                     /protein_id="WP_002757651.1"
                     /transl_table=11
                     /translation="MGLPWYRVHTVVLNDPGRLISVHLMHTALVAGWAGSMALYELAIF
                     DPSDPVLNPMWRQGMFVLPFMARLGVTGSWGGWSVTGETGVDPGFWSFEGVAAAHIVLS
                     GLLFLAAVWHWVFWDLELFIDPRTGESALDLPKMFGIHLFLSGLLCFGFGAFHQTGLWG
                     PGMWVSDAYGLTGHVQPVAPEWGPAGFNPFNPGGVVAHHIAAGIVGIIAGLFHLTVRPP
                     ERLYKALRMGNIETVLSSSIAAVFFAAFVVAGTMWYGNATTPIELFGPTRYQWDKGYFQ
                     EEIERRVEASIANGATIAEAYQAIPEKLAFYDYVGNSPAKGGLFRTGAMDSGDGIAKSW
                     LGHPVFKDGEGRVLSVRRMPNFFETFPVVLTDSEGIVRADIPFRRAESKLSIEQSGVTV
                     SFYGGSLDGQVFSDPADVKKFARRAQLGEAFEFDTETLKSDGVFRTSPRGWFTFGHAVF
                     ALLFFFGHIWHGSRTIYRDVFAGVDPDLEEQVEFGLFQKLGDLSTRKQEV"
     gene            complement(17712..18023)
                     /locus_tag="LC603172_RS01175"
                     /old_locus_tag="MAN88_02330"
     CDS             complement(17712..18023)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016515948.1"
                     /locus_tag="LC603172_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02330"
                     /product="hypothetical protein"
                     /protein_id="WP_002798470.1"
                     /transl_table=11
                     /translation="MKYFFLTAGWTIGRVWEFGGLWDHASSWRRPPQIERLNIGILEGE
                     QVLWLYKVEEAVIMVEVAPKSAEIADTVPTIGQVVLKRLISAEQVLEILQNAEEVLRK"
     misc_feature    18085..18098
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.88"
                     /tool="antismash"
     gene            complement(18102..18863)
                     /gene="tatC"
                     /locus_tag="LC603172_RS01180"
                     /old_locus_tag="MAN88_02340"
     CDS             complement(18102..18863)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0015628 - protein secretion by the type II
                     secretion system [Evidence IEA]"
                     /codon_start=1
                     /gene="tatC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002770330.1"
                     /locus_tag="LC603172_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02340"
                     /product="twin-arginine translocase subunit TatC"
                     /protein_id="WP_052275580.1"
                     /transl_table=11
                     /translation="MSSTEVKTPPPDSPEYLDELPGEVEMSLFDHLEELRRRIFYSLIA
                     VAVGAVGCFIFVKPLVQVLEVPAQGVKFLQLAPGEFFFVSLKVAGYSGILVASPVILLQ
                     IILFVLPGLTRRERRLIVPVVLGSSVLFFAGLFFAYIALIPAALNFFVNYGAEVVEQAW
                     SIERYFEFVLLLLFSTGIAFQIPVIQLILSFLGIISSQTMLSGWRFVVLGAVILGAILT
                     PSTDPLTQSLLAGAVLGLYFGGIGVVKLTGR"
     gene            18862..19152
                     /locus_tag="LC603172_RS01185"
     CDS             18862..19152
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC603172_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_221275455.1"
                     /transl_table=11
                     /translation="MALARSFSTQAFILALLTLGLESVISYQLPVIRCEFLVDSLNRGS
                     VFSFYLFSLLPISPSPHLPISPSPHLPISPSPHLPISPSPHLPISPLPHSP"
     gene            19216..20175
                     /gene="nadA"
                     /locus_tag="LC603172_RS01190"
                     /old_locus_tag="MAN88_02350"
     CDS             19216..20175
                     /EC_number="2.5.1.72"
                     /GO_function="GO:0008987 - quinolinate synthetase A
                     activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nadA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012594145.1"
                     /locus_tag="LC603172_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02350"
                     /product="quinolinate synthase NadA"
                     /protein_id="WP_061431903.1"
                     /transl_table=11
                     /translation="MFTTVQPANRSSLPDDLFTAIKELKRELNAVILAHYYQNSDIQDI
                     ADYIGDSLGLSQQAARTPADVIVFAGVHFMAETAKILNPDKLVLLPDLDAGCSLADSCH
                     PEDFARFKAQYPDHIVISYINCSAEIKAMSDIICTSSNAVKIVNQIPAHQPIIFAPDRN
                     LGRYVSQQTGRDLVLWQGSCIVHETFSERKIIELKVAHPEAKIIAHPECEASVLRHADY
                     IGSTTALLNYSLKSSEKTFIVATEPGIIHQMQKSAPEKLFIPAPALNNCACNECPYMRL
                     NTLEKLYLCMRDKTPEITISEDLRVKALLPIQRMLEMS"
     gene            complement(20324..21781)
                     /locus_tag="LC603172_RS01195"
                     /old_locus_tag="MAN88_02360"
     CDS             complement(20324..21781)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002783794.1"
                     /locus_tag="LC603172_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MAN88_02360"
                     /product="DASH family cryptochrome"
                     /protein_id="WP_061431904.1"
                     /transl_table=11
                     /translation="MRVLIWYRNDLRVHDHEAIYRAIQEQFEIIPFYCFDERQFGFTSY
                     GFPKTGKFRAKFLLESVADLRQSLESLGGNLIIRRGKPEDIIPQLVQELQIAKVYYHQE
                     VTAEELAVEKAVNKALSGVPVQIKTFWTATLYHPDDLPFTLNQLPELFTNFRKQVERHW
                     QIRATYPTPKKLTKLPKIELGNLPSLNDLGLTEPILDRGGVLSFQGGEMAGKSRVKEYI
                     WDSDSLKTYKETRNEMLGTNYSSKFSAWLSFGCLSPRYIYEEVQKYEQIRVKNDSTYWL
                     IFELLWRDFFRFICSKHGNKIFYKSGLQELYLPWLEDWERFNLWCEGKTGYPLVDANMR
                     ELAATGFMSNRGRQNVASFLSKNLGIDWCMGAEWFESLLIDYDVCSNWGNWNYTAGVGN
                     DARGFRYFNIPKQSKDYDPKGDYLRHWLPELALIKGDKIHEPYKLYPEEQKLYGVILGV
                     NYPRPIVDFFQSIKHNEKIYLQHFTEQ"
     misc_feature    complement(21852..21872)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.14"
                     /tool="antismash"
ORIGIN
        1 cgtcaattct ccagtttata caagaaaata atctaattaa atcctcaaca gtgatgaaaa
       61 ttttgttatt tagtcgctac gatactttag gtgctagtag ccgctatcgt acttaccaat
      121 atttgcctta tttcaaaaaa gagggaatag aggttgagac cgctccctta ttagataatg
      181 attacctgag aactcgctac ttagggaaaa aatacccttt atcgagatta ttatctgctt
      241 atcaacagag aatttcgctg ctgttgcaat ctcaaaaata cgatttaatc tggttggaaa
      301 aggaagcatt accttggcta ccagcttggc tagaattact gttgctcaga ggaagaacac
      361 cttatgtagt tgattatgat gacgcagtat tccaccgtta cgatcaacat tctgctccta
      421 tagttagatg gctattggca cagaaaatcg atcgagtaat gcagaatgct cgcttagtga
      481 ttgcgggaaa tgattactta gctaaccgag caacacaagc aggagctaaa tgggtagaaa
      541 tattacccac cgtcgtcgat cttgatcgct atcccttatc aaaagctcct caaaatgaag
      601 tctttaccat cggttggata ggaagtccat tgaagtttgt cgattatata caagaacttt
      661 atcctgtttt aaaagaaatt tgtcgagatg gtggtgccaa agtcgttgct attggtgcta
      721 aagagacaaa tctagaggat atacctttag aaattaagcc ttggtcccag gcaaccgagg
      781 tgaaggagat gcaacaattt gatgtgggga ttatgcccct taccgataca gcatttgagc
      841 ggggaaaatg cggatttaaa ctaatccaat atatggcatc tactcgagca gttattggtt
      901 caccagtggg ggtaaatgcg gagattatta aggaggggat caacggcttt caagctagta
      961 gtcaagctga atggctgcaa gcttttcaaa acctgaaaaa tgatcgagat ttaagagaaa
     1021 gtatgggatg ggctggcaga aaacttgtcg aagataagta taatattcaa ataaccgccc
     1081 ctaaaatgtt gcagctattg caaaaagcta atcaagtctt aaaaacctaa aactgttttt
     1141 ctaaaattat ccataaatca agaatctaaa ctgtgcatga aatgaaaata ctttttatta
     1201 taactagagc agataccgtt ggaggcgcac aggttcatgt acgagattta gcgagatttt
     1261 tgcaagattc tcaccatcaa gtcttagttg ttactggaat aaaaggcatt tataatgacg
     1321 atctgatcag tcatcgcata accaatatat cttgtcaaga ctttggcaaa aaaattaact
     1381 taattcaaga ctggcaaacc ttgaatttta tcaaacaaat tattgcagaa ttccaaccag
     1441 atattatcag cactcactct agtaaagccg gaattttagg acgattagcg gtcagaaaaa
     1501 gcaagactcc ttgcattttt accgcccatg gttgggcttt tacaggaggt gtaccagagc
     1561 cgagtcgcac tatctatcag tggttagaaa caatcacaga acctttagct aataaaatta
     1621 tctgtgtttc ggaacaagat cgattaattg gaataaaaac tggtatgcaa ccgcagcgat
     1681 tattgaccat tcataatggg atgccagatc tacccgcaga attgagagct aatcctggta
     1741 atgctaaccc tgttcgtatt gtcatggtgg caagatttga tcagcaaaaa gaccatgtaa
     1801 ccttactgaa agcctttcaa aatattcccg aagcccattt agatttagtc ggagacggtc
     1861 cggatttaga aaagattaaa accttagcta aggagctaaa aattatcgac agagttaact
     1921 ttttaggttt tcgtaataat gtagctgaag tcttagctca agcccaagta tttactttaa
     1981 tatctaattg ggaagggttt cctcgcacta caatcgaagc aatgagagcg ggattaccag
     2041 taattgtatc agatgtgggg ggagcatcgg aagcaattgt ggaaggaata actggataca
     2101 ccgtagcgag gggagatgtt aacacgttac accagagact attacaatta gttcttgatc
     2161 aacaattcag agctaaaatg ggagcggcag gacgcaaacg ctacgaaaca gaatatactt
     2221 ttgagaagat gtttgaaaaa acctttcagg tttatgagca agttttagcg gaaaggagaa
     2281 aaaatgatga tcgagaataa aatattaatc acaggtgcta cgggattgcc tggtggtttt
     2341 ttcatgcaac atttggcatc tactaagcct gaaatagaaa tacattgttt aattcgaccc
     2401 agtagcgacc gcagtatgtt agatagtcta ggactgaatt taacctacga ttttggcgat
     2461 agctctatct cagaaacctg ggaaggaatt tttagggaaa atagttttga aaccatcatc
     2521 catctcgtcc aacttcgaca agtaccaact atacttaata gtctaaaaaa attccaacaa
     2581 actccccgat taattattat tggaaccacg ggagtatatt caaaatataa tgaatattct
     2641 gccgagtata aacaagcaga aaattattta caagagtatc ctgcttctta ttgtctgctg
     2701 agaccgacaa tgatttatgg cactcctaag gataaaaacc tacacaaatt gattaaattc
     2761 tgtcaccgct acggattctt tcccattttt ggctctggtg ataacctgtt acaaccagtt
     2821 cacgctgatg acattgccca gatgttgtta aaagtctggg aatgtcctga tataaaaggt
     2881 gcttacgatc tttccggcgg tagtattgtt tccttccgtc agttaatttt attgatagaa
     2941 caattattag gccaatcggt gcgtcccctg tcctttccct tgaactttgg catttggtca
     3001 gctaccctac tagaaaaaac attagctaaa aaatcccccg tgcgacgaga acaaatcttg
     3061 cgattacaag aagacaaagc ttattcccac gaagaagcta aaagggattt agggtttact
     3121 cctcgtactc tagaagccgg actacaacaa gagatagaat taatgcgctc ccaaggcata
     3181 atttaactaa ttaagtcaat ttttgtcttg actctagcca tattcaaaaa accctggatt
     3241 ggcaacctcc cttggttgaa gcgtcgagct tatgctaatc aagccagtgg tgcaactaga
     3301 acttttgtta cctgcgttga caatagggta gttgggtatt acgcccttgc ttccggggcg
     3361 attagtatac aatcagctag aagaagctaa gaatttttat ttggctttag gttttgatgt
     3421 gtctcctctt gaaccgatga cgttgatgat tactcttaat gatttacgcg ctcgtattgc
     3481 ttagtgcgct acaggggcaa cacgggggca acccccctgt ggttgcccct acaggtacgt
     3541 ttaagtccag aataactaag attctgggac taaataacga cgagagttaa ccaacacagt
     3601 gcgatcgccg acgattgtag gttggattga ggcaacgaaa cccaacccaa cactataata
     3661 accctaaaag tttacatcca caggggaaaa ggatttaatt catcttccgt taaagcttct
     3721 tttaaccatc ccatcttaac aggaacatca tacaatcttc ctagccctaa acgcttccac
     3781 atatgacgca ttccggggac aatgacttta gctaccctta acccacattc cgcaccctca
     3841 actgtcacat aagctgtccc cctccagaga cttgagtaaa aatacttagc tggtgaaggt
     3901 tttctcggtg gccgttaggg ggagcttgag acccctaatt atgaaaaaat aggaattgtt
     3961 ggaaaactga ggcgagtgga ctgttcgacc atgaatcaat caacagaaat tgaagtcaaa
     4021 aatctagacc atctgggatt agtagccgga attatcgatg aaataggaat cgttgaaatt
     4081 atcaacgaac aagtctcaat tgagcgagga gaaattgtca cagcggggca agtcgtgaaa
     4141 gcaattatcc tgaatggatt gggatttgtc tcccgagcct tgtatttatt tcctcaattt
     4201 tttgaagata aagcaaccga acatctgctg ggagaaggca tcgaagcaaa acacctgaat
     4261 gatgataaaa ttggtcgagt aatggacaaa ctttatcaac ttaatgtttc ggtcattttc
     4321 ctactcatta gtttagccgc cgtcaaaaaa tttggtgtag caaccgagaa ttcccattta
     4381 gattcgactt ctctatcagt agaaggagaa tataacaagg aatacccaac agtagaaatc
     4441 ctgaaatcag gagcagtggg agaagaaatt gaaaccagac aacagccaat aaaaattacc
     4501 tacggatact cccgcgaccg acgacctgac ttaaaacaat ttatgattga cttaatcgta
     4561 agtggggatg gagatgtacc tttattcctg aaagtagggg acggaaatga agcggacaaa
     4621 gcggtttttg gtcaaatcgc ccgagaattt caaaaacaag ttgactttga cagtttaata
     4681 gtcggcgata gcgccctcta tagcaaagag aatttaaaac taatgagaga aatgcgttgg
     4741 ttatctcgag tccccttcag cattaaagag gctcaagagt tagtcgatag catctcagaa
     4801 aaagagttaa ccgatgcaga aataccgggt tattcctggc gggaaaccat ctctaactat
     4861 ggggggatag aacaaagatg gttgctagtt gaaagtcaaa ctagaaaaga atcagacttg
     4921 aaaaaattag agaaaaaaat cgagcaagaa aagaattctg cccaagaaaa aatccggcaa
     4981 ctatcccgaa gagaatttga gaatagagcg gtggcgttgg cgatagtcaa gggattatct
     5041 gactccttaa aatatcatca gttaacggag attaaagtca atctcattcc gcctgagtct
     5101 cagcagtcaa aactcaaatc aaaagacgat ttatcctctc aaagctatca agttcaagcc
     5161 gaattagagt tgaatttggc agcgattgag aggctcaaga aacgagcagg acgattcgtt
     5221 ttagcaacta acgatttgga gaaaaaacga ttaagcagtg aggatatact caaaaaatat
     5281 aaggggcaac aagctccaga aagaggattt tcttttctca aagacccctg cttttttgcc
     5341 gacagtgtct ttctcaaatc tccccataga atcgaggtcc tggccatgct catgggcttg
     5401 tgcctgctgg tttatactat tggtcaaaga caacttcgtc tgaatttaaa acagcaggag
     5461 acgggactga aaaatccgtt gggtaagtta actgaccgac caacattacg ctggatattt
     5521 cagaactttc aagggattca tctcctacgt attcaagaca atcaaaagat tagcaactta
     5581 acggatgaga ggcgcaacat tttgagattt tttcccaaac cttgccagga atattatctc
     5641 ttatcttgac cagatggatt gacttcaagg ggtgacaaaa cttaagcact actcgaacat
     5701 ctcgacgcta gatgttaagt ctgattgcct agtcattctc aacaagcact gtttattgcg
     5761 aatgaccggg ggaaccctga atttttcgac ttagttgccg gcagcttgcc gccaactcac
     5821 tcctctagat aagtattttg actcacgctc cttcctcttt cgagacgttg tgacacttag
     5881 ggtgcggaat gtgggcctta aaccaatatc aggacgagtc tgatctaata ctaacatttc
     5941 catccccttt gactcaatct ctataatttg attgattaat tcatttgttc tacttaagag
     6001 attacgccat cataccataa agtgaccctt tgaattaggg gtcgagaagg tcgtcaccga
     6061 cctcccctcc cattcagaac cgtgcgtgat actttcgcat cacacggctc ctagtttgac
     6121 tgttcccttg ttaagcagca attccaaatt caaacggtag tgtaggatac agaattgatt
     6181 tcgcttctgt ccctcaaaat agagtgaacg agttgcccat tgggttttgc aggaatggaa
     6241 gtccaagatt tgagttttat agggatgctg agctacttcc acagggctat cgctggcatg
     6301 gttgacccgc gcagtgctag caatgctact cgctacagtc taaaagacgc ggtcttgggg
     6361 gcatttgcta gcttctttat gcaaaatgaa tcctttctag aatatcagcg tcaattgaat
     6421 agtcgttgtg gacgagataa tgctcaaagt ctgtttggtc tggttaatat cccgaccata
     6481 gaacagataa agaatattct cgatagaata gccgcaaagc ctcttttttc accgttcaaa
     6541 tggatttatc aaggtctgag agaacaaggc tatttgaggc tgtttacagc cttggatggc
     6601 aacttactcg tcgccctaga tgggactcag tactatgatt cagagaaaat tagttgtcct
     6661 tgttgctcaa cccgcacctc gaaacagggg aaggtaactt atcaccatca agctattttg
     6721 cctgtaattg tctctcctga ccaaaaatcg gtcatttcct tgccaccaga atttatcact
     6781 cctcaagatg gcagtgagaa acaagactgt gagcaaaacg cggcaaaacg ctggatagcg
     6841 agccatgcgt cctggtttga aggccagccc atcaccctct taggcgacga cctctatagt
     6901 cgccaaccga tggctgaata ttgtttggaa caccatttca actttatctt tgtctgttta
     6961 ccgtcctccc atccgactct ctatgagtgg gtttctttcc tggaggctaa tcaagaagtc
     7021 aaaaccactc aacagcgacg ttggaatggg cgatactttg aaatttggga ctatcgttat
     7081 ctcaatcaag tccccctgcg cgaacaacaa cccgccttac tggtcaattg gtgtgaggtg
     7141 accgttaagc gcgagtcgga tggtcaactt ctctatcgca atagctggat tactaaccac
     7201 gacctgactc cccaacgggt cattctggtc tgcgctgctg gacggagccg ttggcgaacc
     7261 gaaaatgaga atcacaatgt gctcaaaact cggggctatc atttggagca taattttgga
     7321 catggtcagc aacatttgtc ctcttttctg ttgaccctca atctcctggc tttcttattt
     7381 catactgttc tgcatctagt cgatgaacgc tatcaacggg ctcggatgca aagggggact
     7441 cgcagaggct tttttaacga tgttctttgc ttaaccaagt atctgctgtt tgaaggctgg
     7501 caccaccttt tagactttat gctcgatgag gccatccctg ttactcgcgt taattcttct
     7561 tgattttgga tggggagcta cagggcaaaa gcgttttgta ttctgtattc cttgctacat
     7621 tctgaatttg gaattgctga cgcagtgtgt caacctattt cactactcat ttattacgat
     7681 ggttcaggtc ggacattcgg ctcacgtcta atcatggatg gttggcagta gtctcgattc
     7741 tggtgttagg ttacacctcg gagccttccg ttccccgctt cagtcccaga gttgtgactt
     7801 ctgaatctgg gggtggctat cgccgttact ctcacccttg tagcaattgt aaataattgt
     7861 tacaaagtgt attgaccttg agttcccttg cctagtttgg tatcgggtga tactaaacgt
     7921 cgggacatat aaacagttat aaggttggtc tgggttgacc tcttagattc agtcagggga
     7981 ctgaagacct tactaggcgg ttatttcggg catttcagcc ctatttcatg cctaaacgtt
     8041 tcgcacatct aatataaatc taatataaat ctcatataaa agttaatatt ctactcaaaa
     8101 aaacctatta gaaaagtatt aactttagag attgccatta ccacaaataa aacttattct
     8161 ggtatcaaag gtgattaaac aaatcacttt taaccccaaa gacaaggcat tttgcttaag
     8221 gcattatggc taatctaaaa aattcagaaa tggattttgg agaacgtctt aatgggactt
     8281 agacaaaaaa acaatcgaga aaagcctcaa ctccaatccc cgcttgggat ttacttcgag
     8341 aagcccaaaa tcgctgaaac ccagatagat caaggaaaat cataaatcga ggttaaccct
     8401 ttgtcccgta atggtttgag ccttttttgc tgaccgaaaa cgcctcagtc ccattaaggg
     8461 tgtaaagaca agaaacttaa ggagaaaatc atgacacaag tgattcagac tggtaaaact
     8521 ttaaaggcag gcacgggaaa gataacaatt aacttcccga aaccatttgc tcaaattcct
     8581 gttgttgttg tctcatcttt ttgggaaaac gtaggaagcc aagttggaaa tattgagact
     8641 atagacacaa tatctcttga gagcttcact atagttagtt ctaatgctgc tactaactac
     8701 tatgtgaatt ggattgcaat ttcacaagag taagtttgat ggcctctctt cttagcatta
     8761 gttgagcgtg atcgctcctt attctcgatt agattgaaac aacgaaaccc aatactaata
     8821 aaggtgtgtt accttagtga catacctttt atctatcagt catcaggaga gcttatttat
     8881 agcgtttcct gttcgcaaga ggtacattct cgatggtgaa aagcttaatc agcaaaggtt
     8941 taactgtgcc atacaggtgc gagaatcgct atattttctg cttagagcag ttaaaattga
     9001 ggaatgatcg gcccagaaat tgggtttatc ttcgtactta accttaacat gagagggaat
     9061 caaagatgct ggcaatatcg atgttctatg aaatcatcgt ttataggtat tttatagata
     9121 acaaacaaca ctatatacgg cacattaacg ctaggtatca agaggatgaa gtaattgtct
     9181 caatccctga tggtgaagtc cttgaaggtt cgagttaaac taaaatgatc atcatcttgc
     9241 ttgttaacta acgaacaatt gacaaactga tgatcctgtt atactaaatt aggtataaac
     9301 cataatcatt aaccccaaca tgggagataa acccatttac tggattggga cgtcaaggga
     9361 agatattaga gattttcctg aagacgcaaa gcgtaaagca ggttttcaac tgagagctat
     9421 tcaacaagga gagaaaccca atgattttaa acccattccc attattggtc aaggaacaga
     9481 agaaattaga atttggacag gagaaaccta cagaatcttt tatgtggcaa ggtttaaaga
     9541 agcgatttat gtccttcatg ctttcggtaa aaaaacacag aaaacctcga aaaaagaaat
     9601 tgaattggga caaaaacgtt atcaacaaat gattcaattt agacaacaat tacaggaggg
     9661 ataaccatga cacaatctaa ccctattgag atcacttttg gtagcgataa catctttgaa
     9721 gatttaggat ttaacagtga agaagcaact aacttaaaaa ttagagccga tttgatgtta
     9781 accttgcggt cttttatcca agaaaaaaga tggacacagc aagaagccgc cacttttttc
     9841 gaggaaacaa aaccgaaaat tagtgattta atgaatggag aaattagccg ttttactgtt
     9901 gataaattac tcagtctttt agataaaacg ggaatgaaag ttaaactcga aatcttcacc
     9961 aagtaactta aaatcatcaa caattgacca tgaacaaggg ttacatccac atgggaaaag
    10021 gattcaattc atcttccgtc aaagcttctt ttaaccatcc catgctaaca ggaacatcat
    10081 ataatcttcc tgcccctaaa cgcttccaca tatgacgcat tccggggaca atgactttag
    10141 ccacccttaa accaatatca ggacgagttt ggtctaatac taacatttcc atcccctttg
    10201 actcaacaat tcgctgacac aatttaacat cctctaataa gtcatcacta gctaattgta
    10261 aataatcatt actttttttc ggtattattt tactatcggg aactaaataa gattgattgc
    10321 ttaaccttgc cttttgccac catttaaccg ccaaaggatc cgcagaagga ttgtaaatcg
    10381 ttgtcccatc gtccttaaaa gataacacat tcggtaagat ttgattaacc tccgttaacg
    10441 ctcgactaat agcaattttc gggtcaaaat gcgccccata tcctaataaa atatcttccg
    10501 cttcccgctc ctttctcgga ctaatagccg caaaacaggg aatattcaaa tcactggtaa
    10561 tatctaacac ccatagctcc cgatttaacc cctcataata ttgctttaat tgctcaaaat
    10621 atggctcatt aaagctctct aaattaaggg aaggtttaac taattgatta taccaccata
    10681 aggccacaca atctcgttcc actaactcca taaatccttg taaaatcgct tcctctatcg
    10741 tatttcctgc ggcacagcca ttagaatcag cccaacaatc taagggttca gattgaggat
    10801 aaccataata acaatatcct gtcggtaaat acttaaaatc ttgagcagtt aaagaccata
    10861 caggagtcca atcaatgatt ctagtttcat caaaaggttc aggtactttt tgaaaccatc
    10921 cttgattctt cgcattccat tcttctcgat gttgatattg tttttcacta aaattcatac
    10981 atttgttagg atgaatagct tcatctccta actcttgata actcgctttt tctctgattt
    11041 cattcccttg aaaaaccccc gaatagcgct caatagcttc acaaaatcca cttgcttttg
    11101 cttgactatc tgtacggcct tttcccgcac ttctacctcc aatattttgc cgtaaactgt
    11161 ctaaatcatc aaacaggccg cgaaaatgat gtttcgccac ataagtatga actaaagtat
    11221 tcccttgaat cttatttaat tctcgcacaa ttcccgtaat gggactgata agatgttgat
    11281 aggttcttag ggtttcttca ggagaacaaa aacgatgtcc accatcattg gtaaacccct
    11341 ttttccgatg tcccaaaacc acgggtaaag gtgttttatt tagagaatat ccacaactag
    11401 gacagttcgg acgtttaact aaaatatgct cttgaaattg taaatttaaa gtatcataag
    11461 tcattagcat tccttctaaa cgttgatttt taccttgaat aatccactta aaaacctcca
    11521 tagccgtcag atttaaaacc gtctgtattg tcgctgaaga aaaccctaaa ggagaaatta
    11581 aagaaatctt attttctctc tgtctaataa taaattcctc cacgggacga ttatctcgta
    11641 atcgttgagc caaacaatgc caacaaccag ttttatcggg atcaaataag ggaccaatcc
    11701 aggctaggtt tcccagggga ttaactaata accaaggctt gtgcgaggct aaagcttgtt
    11761 gattaatact ctctaaatca ggatgaagat aattatcggt taaaataatg gttaaatccc
    11821 cttcatctgc gacttgaact tgcaaggaat ttaaaatatt gatcaaatct tgctggggaa
    11881 ttaagcctag ggttttaact gtaaccttca gagattgtaa tcgttcaaaa gcttgggctt
    11941 gagaaacccg aagatgatgg cataaaattg ctaaattaga cggcaataat tcttgttttt
    12001 ctaacaaaaa ccctcgttta tataactgaa aaatcgcttt ttgaattgcc aagctataat
    12061 taacaataac tgcgaaggaa ttagcattat tgggattgat ttcctgattt tgtaaaaatt
    12121 ctaactgaag aatatcaata atttcatcaa gattacgttg accatcaatt aatcttacca
    12181 aacgataata aagcggctct tggaaacaga ttgattctcg ctcagataga aaaaataccg
    12241 tatttggttc taaggtttca attgagtagg caggattcca atcaagctgg ttgaacacaa
    12301 tttttactct ctttttaagg tatagttaag gttgatgata tacctataat ataaggttga
    12361 tagcagtcat cttaatagtg aggtgcgaag ttttcgtttt ggggaacagg gagggagcag
    12421 cccatttatg ccaaaatata aaagcgatcg ctaaaagtga ttaaatttat gcaatatgat
    12481 accaaatccg cttttaatag catgattaac tcccaatcca actttaaaaa cccagttatg
    12541 gattgttttg cccctgctcc ctgctccctg ctccctgctc cgcagctccg gcactcccca
    12601 atctcctcca ccttttaaac aggatttggt atcagccccc taatttcttc cctgcctaaa
    12661 atttctcaat ttctcggaat aaatttgact accaaaatca gggtaaatag cccaaatatc
    12721 aacttaataa agttttaata gacatttaag ctctaataga ttaatcctac tttttttaaa
    12781 gccgatatgc tgcctcgcta atccttttaa gacttgaaaa cttggtattc tgtcaggggt
    12841 tggccgtgag aggtgtcaat tttcaaggat aatttgtaac agagtgttga aaattccttt
    12901 aatcttagtt atgagcgatc gcccaccaga actaacccta gccgaccagg cccctgccaa
    12961 ccacgaatgt cgctcctgcg gctacgttta cgaccccagc aagggagata gtaaaaccaa
    13021 cactcccgct ggaaccccct tcgaggaatt gccagaaacg tggcgctgtc ccgtgtgtgg
    13081 tgtgcgtcgt tcccaattta tcaacatcgg agctaaagat gctccttcgg gattccaaga
    13141 aaatcttagc tatggttttg gagtcaaccg tctgactccg gcacaaaaaa atattttgat
    13201 tttcggggct ttagcgctag gatttgtttt ctttattagt ttgtatggtt taaactaact
    13261 caagcactca ttatctttaa tccaacggct cttatgagcc tgtaacccat cgggtacaaa
    13321 ccctaatccg tcccgattcc ttgaccaata cctctgaacc attgatgaga aaactgaaac
    13381 aattcgtaat agttctagct gtagcctttt tctgctttag ctgtagtagt gtgccatccc
    13441 tgagcagtag tccttggcaa atcctcaccc tcgacactga ctccactttt gccgatatcg
    13501 cctttaccga cgacctgcag cacggttggt tagtgggaac caaatctacc ctctttgaaa
    13561 ccaccgatgg gggggacagc tggcagcaaa aagtcctcaa ccttggcgaa gaaaaagtta
    13621 gctttagcgc cgtcagtttc cacgaccaag agggttggat tgtcggtaaa ccctcaattc
    13681 ttctccatag cgaagacggg ggcagcagct ggtcccgtat ccccttaagt gaaaaattac
    13741 ccggttcccc ctacggaatt atcgccctta acgacaaaac cgccgaaatg gtcacggatt
    13801 taggcgctat ctaccgcacc aaagacgggg gcaaaacttg gcaagcttta gtggaaggtg
    13861 ctgtgggtgt ggcccggaca attgttcgtt cccatgatgg taaatatgtg gccgtttccg
    13921 cacgcgggaa cttttattcc acttgggaac cggggtcaac agaatggcaa ccccacaatc
    13981 gtctttcttc ccgccgttta caaaaagtcg gttatggtga gaaaggggaa ctgtgggccc
    14041 tggcccgggg tggtcaacta caatttacta gccccaatga tctcgataca tgggaagata
    14101 aggtattccc agagttttcc accagttggg gacttttgga cctcaactac cgcagccccg
    14161 aagaaatttg ggtcgctggt ggtagcggca atctcttggt cagtcatgac agcggccaat
    14221 cttggcaaaa agatcgcgcg gtggaaagtg tcccctccaa tctctatcga attgttttta
    14281 tcaattccga caagggtttt gtcttgggac aaaatggggt tttactgaaa tataatcccc
    14341 ctagcgaatc ggcctaaaac ttgtgtcagg gtcaagaaag tctctattat agagattgaa
    14401 tttttcaagt cctatcattc cgaggagaac cgtccatgtc aggtagtacc ggcgaacgtc
    14461 cttttggcga tatcgttacc agtattcgtt actggattat ccatagcatc accatcccca
    14521 tgctgtttat cgcaggttgg ttattcgtga gtactggttt agcttacgat gtttttggca
    14581 ctccccgtcc cgatgagtat tacactcaag agcgtcaaga attaccgatc attaatgatc
    14641 gctttgaggc caaaaatcaa atcgagcagt ttaatcagta gtttacttta attaaggata
    14701 aaaacaatgg ctagtggtaa tcccaatcaa cccatttctt accccatttt caccgttcgc
    14761 tggttggcag ttcatacctt agcggttccc actgtcttct ttatcggtgc aattgcggca
    14821 atgcagttta ttcaacgcta ggagaacaat tatggaaaga acacctaatc cgaatcggca
    14881 agctgtcgag ttaaatcgta cttctcttta cctaggttta ctcctagttg ctgtcttggg
    14941 aattttattt tccagctatt tctttaacta attagtcccg attcattgtc atcgcaatta
    15001 ggaggtgtta ttcatgttcg cagaaggtcg tattcctttg tggttagtcg ccaccatcgc
    15061 cggtctaggc gttatcgccg tggttggtct tttcttctac ggagcttacg ctggtttagg
    15121 ttcctctatg taattccatt ccaggtaatt tccccaggca aaaagccgtt agttatttct
    15181 ataactagcg gttttttcac tattcggtta aaagtaaagc tcgatcgaac tttaatacca
    15241 aatccgtttt taatagtgtg attaactctc aagttatcaa ttgtttctcc ctgctcccca
    15301 ctccctgctc ccttctcccc acaccccaca ccccactttc ctgtaccttt taaacaggat
    15361 ttagactaaa tcctgttatt aaaaactgat tatttattcc cgcttttgcc tcttgcctat
    15421 tgcctcttgc ctcttgcctc tcctgatatg tagcctatac tcaacggatt tggtattagt
    15481 ctcacgtttg caggagagct aataattagg gtttgctgaa aaagtttgtt ggtggggtta
    15541 ggagtcggtc gtcaggagtc tccgagtcag tagccggtcg tttcaggctt tgttgccctc
    15601 tcttttcgta ccagtttatg tactacaaga aggataatgc aaggtttttg agggtctcaa
    15661 tccgattttc gcagcatgaa catcggattt taacaggtca aaagccttat tttaaaaggg
    15721 ttttaccatt attcagcaag ccataattaa caaaaaaagg agtcaaagac ttgactcctt
    15781 tagttatatt gatgatttag ctaaaactaa acttcttgtt tacgagtgct aagatcaccc
    15841 aatttttgga ataaaccgaa ttccacttgt tcttccagat cgggatctac cccggcgaat
    15901 acgtcgcggt agatagtacg agaaccgtgc cagatgtgac cgaagaagaa tagtaaagca
    15961 aagacagcat gaccgaaagt aaaccaacct ctcggagaag tgcggaatac cccgtcagac
    16021 ttcagggttt cggtgtcaaa ctcgaaagct tcaccgagtt gcgctctacg cgcaaatttc
    16081 ttcacatcag caggatcgct gaacacctga ccatcgagag agccaccgta gaaagaaacg
    16141 gtaacaccac tttgttcgat actcagtttc gattccgcac gacggaaagg aatatcagcg
    16201 cgaacgatac cttccgagtc agtcaggaca acggggaagg tttcaaagaa gttaggcatc
    16261 cgacgcacgc taaggacgcg accttcgcca tctttgaaca cggggtgtcc taaccaagat
    16321 ttagcgatac cgtcaccgct atccatggcg ccagtacgga ataaaccacc tttagcgggg
    16381 ctattaccga cataatcata gaaagccagt ttttcgggga ttgcttggta agcttcggcg
    16441 atggtggctc cgttggcgat gctggcctcg acgcgacgct caatttcttc ttggaaatag
    16501 cccttatccc attggtaacg ggtcgggcca aagagttcga tcggggtggt agcattaccg
    16561 taccacatgg ttccggccac gacgaaagcg gcaaagaaaa cggcggcgat actgctagaa
    16621 agcaccgttt cgatattacc cattctcagg gctttataga gtctttcggg gggacgaacg
    16681 gtcaaatgga ataaaccggc gataatcccg acgatacccg cagcaatgtg gtgagctacc
    16741 acacccccgg ggttaaaggg gttaaaacca gccggtcccc attcgggagc tacgggctgc
    16801 acatgaccgg ttaaaccgta ggcatcggaa acccacatcc caggacccca aaggcctgtt
    16861 tgatggaaag caccgaaacc gaagcagagt aaaccggata agaacaggtg aataccgaac
    16921 attttcggca aatcgagcgc agattcgccc gtgcggggat cgataaataa ttctaaatcc
    16981 cagaaaaccc agtgccaaac cgccgctagg aatagcagac cggataagac gatatgagcg
    17041 gcggcaacgc cttcaaaaga ccagaaaccg gggtcaacac cagtttcgcc ggtgacgctc
    17101 cagccacccc atgaaccagt gacacctaaa cgggccatga agggcagcac gaacattcct
    17161 tgccgccaca tcgggtttaa tacggggtca ctggggtcga aaatagcaag ctcatagagg
    17221 gccatggagc cagcccaacc cgctaccagt gcggtgtgca tcaggtgaac ggaaattaaa
    17281 cggcccgggt cgttgagaac gactgtgtgt actcgatacc aaggtagtcc cattgactac
    17341 gctcctccta ttgacaattt agtgtccact tagacgcttt ttatattcag ggtgaaaata
    17401 taagcccaac actctcgacg gttaagtgca agagttagcc gacctacatt atcccttgaa
    17461 aagtgtatct attctaaaga agtgtaacta ttgttagaac agatttcaag tctttgcgat
    17521 cggtcttcgg ccagaatatt ccagatcagg gagtggggtg tgaggtgtgg ggtgtgaggt
    17581 gtggggtgtg gggtgtaggg tgtagggtgt agggtgtagg gtgtagggtg tgggctgtgg
    17641 gctgtgggct gtgggctgtg gggagatggg gaattatgac tgataactga taactgataa
    17701 ctgataactg attacttcct cagcacttct tcggcatttt gcaggatttc gaggacttgt
    17761 tcggcactaa tcaagcgttt tagcaccact tgcccgatgg tggggacagt atcggcaatt
    17821 tcggcactct tgggggcaac ttctaccata atcacggctt cttccacctt ataaagccat
    17881 aaaacctgtt ctccctctaa aataccgata tttaatcgct ctatctgcgg tggtcgtcgc
    17941 caactactcg cgtgatccca caaaccgcca aattcccaca cccgtcctat cgtccaacct
    18001 gccgttaaga aaaaatattt cactttgtta ctcaatctag aatcaatctc tagctttctg
    18061 gcttaattag ttttcagccg tcaaatttta tcaaaaaact gctaacgtcc cgttaatttc
    18121 accaccccaa tgcccccaaa gtatagaccc aagaccgccc ctgctaacaa ggattgggtg
    18181 agaggatctg tggaaggggt taaaattgcg cctaaaatca ccgcccccaa aaccacaaaa
    18241 cgccagcccg ataacatcgt ttgcgaggaa atgatgccta aaaagctcaa aatcaattga
    18301 ataacgggaa tttgaaaggc gatgccggta ctaaaaagta aaagtaagac aaattcaaaa
    18361 tagcgctcga tcgaccaagc ttgttcgacc acttccgccc cataattgac aaaaaagttt
    18421 aaagcggcgg gaatcagggc aatataggca aaaaataaac cggcaaaaaa taagacactc
    18481 gatcctaaca ctaccgggac aattaaacgc cgttcgcgac gggttaaccc cggcagcaca
    18541 aagaggataa tttgcaagag aatgacggga ctagccacca gtatgccgct atatccagct
    18601 acttttaggg agacgaaaaa aaattctccc ggggccaact gcaaaaattt taccccttgg
    18661 gcagggactt ccagcacttg tactaggggt ttaacgaaga taaaacatcc caccgcaccc
    18721 acagccacgg caattaaact ataaaaaatc cggcgccgca actcctccaa gtggtcaaat
    18781 aaggacattt ccacttctcc gggtaactca tcgagatatt cgggactgtc tgggggcggg
    18841 gtttttactt ctgtcgatga catggctttg gctcgatcgt tctctactca agcctttatc
    18901 ctagcattgt tgacccttgg gcttgaatca gttatcagtt atcagttacc agttatcaga
    18961 tgtgagtttt tagtggacag tcttaatcgg gggtcagtat tcagctttta tttattctcc
    19021 ctgctcccca tctccccatc tccccatctc cccatctccc catctcccca tctccccatc
    19081 tccccatctc cccatctccc catctcccca tctccccatc tccccatctc cccacttccc
    19141 cactcccctt aaaaaaaatt tgctatgatc taggaacttg tttagtattt ggtaaaaata
    19201 accataaatg ccaccgtgtt cacaactgtt caacccgcaa atcgctcgag cttacctgat
    19261 gacctattta cggcaattaa agagcttaaa cgggaattaa acgccgttat tctggctcac
    19321 tactatcaaa attctgacat acaggatata gctgattata ttggtgattc tctcggttta
    19381 tcccaacagg ctgcccgaac gccagcagat gtgatcgtat ttgcgggggt tcacttcatg
    19441 gcagaaacag ctaaaatctt aaacccagat aagttggtat tgctgccgga tttagatgca
    19501 ggatgttctt tagctgatag ttgtcatcct gaggattttg ctcgttttaa agcccaatat
    19561 cccgatcata tcgtgatttc ctatatcaat tgcagtgcag aaattaaggc catgagtgat
    19621 attatctgca ccagttccaa cgcagtcaaa atagttaatc aaatccctgc ccatcaaccg
    19681 attatcttcg ctcccgatcg caatttaggc cgttacgtca gtcagcaaac tggtagagat
    19741 ttagttctct ggcagggtag ttgtattgtc catgaaactt tttccgaacg caagataata
    19801 gaattaaaag tcgcccatcc agaagcaaaa attatcgccc atcctgagtg tgaagcatcg
    19861 gttttacgcc atgccgatta tattggttcc acgacggcac tattaaatta ttccctgaaa
    19921 agttccgaaa aaacctttat tgtcgccaca gaaccgggga ttattcacca gatgcaaaaa
    19981 tccgccccag agaaactatt tatccccgca ccagctttaa ataactgtgc ttgtaatgag
    20041 tgtccctaca tgagactgaa cactctcgaa aaattgtatc tctgtatgcg agataaaact
    20101 ccagaaatta ctatttctga agatttaaga gttaaggcac tgttgccgat tcaaagaatg
    20161 ttagaaatgt cttaatcagt tatcagttat cagttatcag ttatcagtta tcagttatca
    20221 gttatcagat ttgagtttta agtgtgcagt atggattaag tgagcctcat caaatgccag
    20281 tttcctactg tcttttcact gattactgtt tactgattac tgattactgt tcagtgaaat
    20341 gctgaagata aattttttcg ttgtgtttga tggattgaaa aaaatcgaca atgggacgag
    20401 gataattaac ccctaaaatt accccataaa gcttttgttc ctctggatat aatttataag
    20461 gttcgtgaat tttatcgcct tttattaggg ctaattcggg caaccagtga cgtaaataat
    20521 cacctttggg atcataatct ttcgactgtt tagggatatt aaaataacga aatcctcgcg
    20581 cgtcattgcc gacaccagca gtgtaattcc aattacccca attactacag acatcgtaat
    20641 caattaataa cgactcgaac cattctgctc ccatacacca atcaataccg agatttttgc
    20701 tcagaaaact agcgacattt tgccggccac gattcgacat aaatcctgta gcggctaatt
    20761 ctctcatatt agcatctaca aggggataac cggtttttcc ctcacaccag agattaaatc
    20821 tttcccaatc ttctagccaa ggtaaataaa gttcttgcaa accagattta tagaagattt
    20881 tattaccgtg tttactgcaa ataaatcgga aaaaatctcg ccataataat tcaaaaatca
    20941 gccaataggt agagtcattt tttactctta tttgttcata tttttgtact tcctcataga
    21001 tataacgggg ggaaagacag ccaaaactta accaagctga gaattttgag gaataattag
    21061 tccctaacat ttcattgcgg gtttccttat aggtttttaa ggaatcacta tcccaaatat
    21121 attctttaac ccttgatttt cctgccattt cacccccttg aaacgacaaa acacctcccc
    21181 ggtctagaat tggttctgtt aagcctaaat cgtttaaact gggaaggttt cccaactcta
    21241 ttttaggcaa ttttgtcaac tttttcggcg tgggataagt tgctcttatt tgccaatgac
    21301 gttctacttg tttacgaaaa ttagtaaata attccggcag ttgattaagg gtaaaaggta
    21361 agtcatcagg atggtataaa gtggctgtcc aaaaagtttt tatctgcaca ggaaccccgg
    21421 ataaagcctt atttaccgct ttttctaccg ctaattcctc tgctgttacc tcttgatgat
    21481 aataaacctt ggctatctgc aattcttgaa ctaattgtgg gataatgtct tctggttttc
    21541 cccgtcggat aattaaatta ccgcctaaac tttccagaga ttgtcgcaaa tctgctacgc
    21601 tttctaataa aaatttagcc cggaacttgc cagtttttgg aaacccgtag gaagtaaaac
    21661 caaattgacg ctcatcaaaa caatagaagg gaattatctc gaattgttct tgaatggctc
    21721 gataaattgc ctcgtgatcg tgaacccgca gatcattgcg ataccaaatt aaaacccgca
    21781 tttaacatca attaaaagtt gataactgat aaatagtaac tgggatggaa tttaattatc
    21841 ttttgccgta gtaatggcca tagtaacgat aattgtggtc tttccgacta acattattag
    21901 ccactaaacc taacacggaa atgtgggata atctcagatc ttccagcaga tttttaagcg
    21961 caaagcgatc ggttttgccc agtttggtga cgagaattag gccagtggcc atggcggcga
    22021 gaattttcgc atcggcaaaa gcaccgatag gtggtagatc gtagataatt agatcgaagg
    22081 cgtggtcttg ctgtaattgc gagatcatct cctgcattct ctgggaagaa agcaagcggg
    22141 tgggatccgg gggaattgaa ccggcggtaa gaatcgataa attctcgtgg cggggtaggg
    22201 attgaacagc ctctttccaa tcgagaccct cggcgaggac attactaagg ccgtggtcgt
    22261 tatcgagatt aagtcgcagg tgagtctggg gtcgtcgc
//
