LOCUS       NZ_AP024135            22602 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9256866
            Orig. end                         :: 9279468
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22602
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="41"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22602
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22602
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12602](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12602)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(453..467)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    1194..1209
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            complement(1246..1896)
                     /locus_tag="K6K39_RS41605"
                     /old_locus_tag="EASAB2608_08259"
     CDS             complement(1246..1896)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="K6K39_RS41605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08259"
                     /product="serine hydrolase"
                     /protein_id="WP_260336071.1"
                     /transl_table=11
                     /translation="MPSRATSLFPALRFRYSNTNYLLLDLIVERITDRDLRTNLERRVF
                     APLKLRDTAYPLAGTAIDGAHAHGYADVSPLLPDAPDATRFDVTAISPSEAGASGALVT
                     TAADVARFYRYLLQGRLLPPELLRQMLSDTVPTTGSAPPAVGYGLGVYVYATDCGLAYG
                     HGGSAPGYLTFALNSRDGRHQLVAHTNWNPLVDAGVDEDFWDAFPQGYCSRPR"
     gene            complement(1793..2434)
                     /locus_tag="K6K39_RS41610"
                     /old_locus_tag="EASAB2608_08260"
     CDS             complement(1793..2434)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="K6K39_RS41610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08260"
                     /product="serine hydrolase"
                     /protein_id="WP_260336073.1"
                     /transl_table=11
                     /translation="MMRRPTRLLSLALALAFLLSPGMATAGQAGDGRASDSRRDPALQA
                     LVDLVVADPNPNPGAFLLARDGTRDRFGAAGVADRSTGTPMRPDLKFRAGSITKTFTAT
                     VVLQLVAERRLRLDDTVHTLLPDQVRADNALSGAPITVRQLLNHTSGLYDYIDGLFPRF
                     RALDQYWPRDQLIGIGLAQPRYFPVPGTPFPVLQHQLPAARSDRRTHHRP"
     misc_feature    complement(1835..1837)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2408..2410)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2496..3137
                     /locus_tag="K6K39_RS40305"
                     /old_locus_tag="EASAB2608_08261"
     CDS             2496..3137
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125391.1"
                     /locus_tag="K6K39_RS40305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08261"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_059256287.1"
                     /transl_table=11
                     /translation="MPRVADHDARHGQITDAVQRLIVRDGLTAVTVARTAAEAGMSVGL
                     VQHYFTAKDEMLLATFTRVNRRFTARVDELVNRGEAEGRTIAVMLRQALAELLPLDDTR
                     RAEHLVRLAFADQAAHNTRLATVQKETLADIRSRVAQAIDNGTVCGEVTGTVDAADQAL
                     RIVACTDGLALHTHIDPDGTPEPAILAALDDQIGRVFTGTCRRARRCQEA"
     gene            complement(3320..4171)
                     /locus_tag="K6K39_RS40310"
                     /old_locus_tag="EASAB2608_08263"
     CDS             complement(3320..4171)
                     /NRPS_PKS="Domain: PKS_KR (5-156). E-value: 4.1e-16. Score:
                     51.3. Matches aSDomain:
                     nrpspksdomains_K6K39_RS40310_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980462.1"
                     /locus_tag="K6K39_RS40310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08263"
                     /product="oxidoreductase"
                     /protein_id="WP_059256289.1"
                     /transl_table=11
                     /translation="MSDTKTFLITGVSTGLGRALARAASAAGHRVVGTVRTPADARAFE
                     ALAGDVHARVLDVTDHVAVDRVVGETERDLGPVDVLVANAGYGHDGLFEESSMDDLRRQ
                     FEVNVYGTVAVIKAVLPHMRERRAGHIIAVTSMGGLITMPGLSFYHGSKFAVEGILETL
                     GKEVADFGIHVTAVEPGSFRTDWAGRSMVRAPRVIADYDKLFEPLRARRIHGSGRQPGD
                     PDKAAAAVLRIVAADRPPTRLLLGTDALRLVRAGRDAFEREMLAWAELSASTDFDDVSR
                     SA"
     aSDomain        complement(3704..4156)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS40310_PKS_KR.1"
                     /evalue="4.10E-16"
                     /label="K6K39_RS40310_PKS_KR.1"
                     /locus_tag="K6K39_RS40310"
                     /protein_end="156"
                     /protein_start="5"
                     /score="51.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TFLITGVSTGLGRALARAASAAGHRVVGTVRTPADARAFEALAGD
                     VHARVLDVTDHVAVDRVVGETERDLGPVDVLVANAGYGHDGLFEESSMDDLRRQFEVNV
                     YGTVAVIKAVLPHMRERRAGHIIAVTSMGGLITMPGLSFYHGSKFAV"
     CDS_motif       complement(4082..4156)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS40310_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS40310"
                     /protein_end="30"
                     /protein_start="5"
                     /score="11.7"
                     /tool="antismash"
                     /translation="TFLITGVSTGLGRALARAASAAGHR"
     gene            4376..5266
                     /locus_tag="K6K39_RS40315"
                     /old_locus_tag="EASAB2608_08264"
     CDS             4376..5266
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061060.1"
                     /locus_tag="K6K39_RS40315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08264"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_059256502.1"
                     /transl_table=11
                     /translation="MDRNTALGEFLRSRRARITPRQAGLPDDGGPRRVPGLRREEIAQL
                     AGVSVDYYLRLERGRRLNVSETVLDAISRALRLDPVERAHLFQLAKPAAGRPRRTATRP
                     QPVRPGLRDLLRILEHTPALVLGRRLDVLASNPMARALLTDFDALPHRERNLVRFMFRD
                     DTARSLYTHWDTHAQDIVASLRRDAGRHPHDPLLAELVGELSIADEDFRRWWADQNVYR
                     HTHGSKHFHHPIVGPLTLHYESLTLPADPDQRLSVYTAEAGSSSEEALRLLAAWIRQPE
                     TSHGRSAGHRTPAGP"
     gene            5437..5913
                     /locus_tag="K6K39_RS40320"
                     /old_locus_tag="EASAB2608_08265"
     CDS             5437..5913
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744777.1"
                     /locus_tag="K6K39_RS40320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08265"
                     /product="hypothetical protein"
                     /protein_id="WP_059256291.1"
                     /transl_table=11
                     /translation="MAVDKDAAFTLPRGATGFFQPKDGPLPETDLRTFRAALHAAARAA
                     EGRVGETEEQTYPRTFHTATVIEGTGECIILCHAHHPWIAFAQERRDWYTEEFLAPPPW
                     AHTFADLGFVVLDRAQLTLPLSDIDTSVLTRAEWRQIRSYGITTLGGVLFNAWD"
     gene            6087..6512
                     /locus_tag="K6K39_RS40325"
                     /old_locus_tag="EASAB2608_08266"
     CDS             6087..6512
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019355513.1"
                     /locus_tag="K6K39_RS40325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08266"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_059256292.1"
                     /transl_table=11
                     /translation="MTTAADIMHPGAQWIPANETLDRAAQLMRELDIGALPVADPQDPN
                     ERMCGIITDRDIVVGCIASGHDPARVTAGELCKGTPRWISTDASVDDVLQEMESNQIRR
                     LPVIDGNKRLVGMISEADLAHHLTDDQLAQFVERVYA"
     gene            complement(6720..>7022)
                     /locus_tag="K6K39_RS40330"
                     /old_locus_tag="EASAB2608_08267"
                     /pseudo=""
     CDS             complement(6720..>7022)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523819.1"
                     /locus_tag="K6K39_RS40330"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08267"
                     /product="response regulator transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="IRSDALLAPALTRKLIDRYVAQPPPARIGSALEELTSREREAVAL
                     AAHGPSNDEIADRLIIGPATARTHINRAMAKLHARDRAQLVVPAYESGLVTPRSS"
     gene            7051..7206
                     /locus_tag="K6K39_RS41615"
                     /old_locus_tag="EASAB2608_08268"
     CDS             7051..7206
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039381.4"
                     /locus_tag="K6K39_RS41615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08268"
                     /product="DUF6223 family protein"
                     /protein_id="WP_260336075.1"
                     /transl_table=11
                     /translation="MAPIAVGAVGTVLAVLHLATASGGPGTGNGLVGAVVAVPLGWAPY
                     CSAAGL"
     gene            7879..8268
                     /locus_tag="K6K39_RS40340"
                     /old_locus_tag="EASAB2608_08269"
     CDS             7879..8268
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007822927.1"
                     /locus_tag="K6K39_RS40340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08269"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_059256294.1"
                     /transl_table=11
                     /translation="MHRVTSLAIASLAVTAALGTAPVASAAAPAPAGSSAAAAFRCDPG
                     YFCIYSGWNGGGTRCQWRSERVANTADLCSFIRNGRNVLSVWNGTGHRVQYYTQTNFNA
                     RVGSTPAGSGGNLQGSYQIRSFKKQ"
     gene            <8443..8670
                     /locus_tag="K6K39_RS40345"
                     /old_locus_tag="EASAB2608_08270"
                     /pseudo=""
     CDS             <8443..8670
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_030275963.1"
                     /locus_tag="K6K39_RS40345"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08270"
                     /product="viomycin phosphotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLWETEDGLPRLSGVVDWDGEELLGRVLALSGGALGGDVPGRIST
                     IRGTFALQQALCAQRDGDEEELADGLTGYR"
     misc_feature    9149..9163
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            9226..9525
                     /locus_tag="K6K39_RS40350"
                     /old_locus_tag="EASAB2608_08271"
     CDS             9226..9525
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08271"
                     /product="hypothetical protein"
                     /protein_id="WP_143650114.1"
                     /transl_table=11
                     /translation="MSKRAIPVVAAAAALVVCTATAAGATSVIGFGNGTHDNRCANHGS
                     TYTVNSVRHTAGSLVAGVLAFSLSAPANQCGDLGLPKEDKVDQPAENFHVDVAE"
     gene            complement(9704..9856)
                     /locus_tag="K6K39_RS40355"
                     /old_locus_tag="EASAB2608_08272"
     CDS             complement(9704..9856)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08272"
                     /product="hypothetical protein"
                     /protein_id="WP_158103184.1"
                     /transl_table=11
                     /translation="MTGRQWDTDERTPSTGCSCLLFAVAAIVFLIAMAGIAAAGIALSS
                     LVSWD"
     gene            complement(10001..11263)
                     /locus_tag="K6K39_RS40360"
                     /old_locus_tag="EASAB2608_08273"
     CDS             complement(10001..11263)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569784.1"
                     /locus_tag="K6K39_RS40360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08273"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_059256301.1"
                     /sec_met_domain="LANC_like (E-value: 8.6e-18, bitscore:
                     63.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHHATTPATPLEDTHDFAVHYLRQWATSPRDSGHPCDPGIPLLA
                     HLVTDTQTAINAITTWARTAGRGPSHPALYDGGLAGTLIGLHLGARLHPVLHPAANRLA
                     AHLRQRPPRYRTHTVTFPDYDLISGPAGTLLALCATDPTETADPNGTAQGADAVGAFET
                     AGAAQPPPRALAAHLALLCDDEELPRLRTGHYAGHPHLAWVNGRINTGMGHGVAGVVTA
                     LTTALRHTHPDQDPDLVDSLTTALGRATRWLIRQAYDDERGIRTWPAAGLDHPPNPKAH
                     PRQAWCYGTPGIAWALWDAADALGDTATADWAAAAFTTLAEHYDETFHLYGDTPQDRLG
                     LCHGAAGVLAVTDAFDHHAELPAATPLKHRLVHHLTHHLASHPLSAWPTDLLNGLPGTL
                     AALLTATRKTPRAWLACLGLR"
     gene            complement(11335..11487)
                     /locus_tag="K6K39_RS40365"
                     /old_locus_tag="EASAB2608_08274"
     CDS             complement(11335..11487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569785.1"
                     /locus_tag="K6K39_RS40365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08274"
                     /product="hypothetical protein"
                     /protein_id="WP_189397488.1"
                     /transl_table=11
                     /translation="MNHNELTELDTLISDLEERITHDDLPATAAYTEGCSGLCTIVVCG
                     TVVIC"
     misc_feature    11492..11506
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(11613..12602)
                     /locus_tag="K6K39_RS40370"
                     /old_locus_tag="EASAB2608_08275"
     CDS             complement(11613..12602)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569787.1"
                     /locus_tag="K6K39_RS40370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08275"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_059256303.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.8e-12, bitscore:
                     45.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPVERLLADCLDDARTQPLGTVPVSAEDPGYPAARRTFLTAGLQ
                     ALRTHPCETGWVQLNLARHPSRTGPPPYHRLATTARELLTSGQASNFFFMHKPPGLRVR
                     FQAADPDQTAHLREELLRRLDPAPGQDPWPPPTPGVYEPETYLFGGPASMPWVHALFTA
                     DSLAWLDLHTHHAGTPPPPAWRLSLTLLHTVFTALHITGWEHRGVWQTVKEETGRRLPG
                     GLNTPDRRRAAAGIRAWWEQTPTTRLHTLPPAWHHTITTHTQTAEQAAQHWHTHYFTTT
                     QATTGPRRAAAHHVIFHWNRAALPTTTQCLLTEALATTTHDHEDTHQP"
     gene            13141..13638
                     /locus_tag="K6K39_RS40375"
                     /old_locus_tag="EASAB2608_08276"
     CDS             13141..13638
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08276"
                     /product="SCO4402 family protein"
                     /protein_id="WP_260336077.1"
                     /transl_table=11
                     /translation="MTDHGIALPHYRLHVVPAVVALASPTWQREVWLDPDQFEDLDYTV
                     HVLFDDFCDANNPRPWLGQCLRSEEEVELMARLGAAYGAVQDSVGAAARGEAYLDSPGW
                     SAVVAAAARLAQVLVANDHLALSKLHDAGHRWPLDTKPIMRSACRGPVAECERCGPSGR
                     TR"
     gene            complement(13568..13888)
                     /locus_tag="K6K39_RS40380"
                     /old_locus_tag="EASAB2608_08277"
     CDS             complement(13568..13888)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08277"
                     /product="hypothetical protein"
                     /protein_id="WP_260336079.1"
                     /transl_table=11
                     /translation="MLCLRESATATRLVTDLAVGTCELSHEALDARISHQRDLAVDYFR
                     AVLVSAGILPVWDEYLARLERWIEQKTAAIKDLEDRRLITAFARWDRIARIRRRARGKP
                     IS"
     misc_feature    14365..14378
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            15070..>15261
                     /locus_tag="K6K39_RS42140"
                     /pseudo=""
     CDS             15070..>15261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414943.1"
                     /locus_tag="K6K39_RS42140"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVEGANSAAQTMPQEQQTRGRHAARRKKDKGGLARSPLLMAVGTV
                     VSRATGLIRQVLQAAALGT"
     gene            complement(15351..15494)
                     /locus_tag="K6K39_RS40390"
                     /old_locus_tag="EASAB2608_08280"
     CDS             complement(15351..15494)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08280"
                     /product="hypothetical protein"
                     /protein_id="WP_189397487.1"
                     /transl_table=11
                     /translation="MTVQIAEELARLHRLVSRFEVPPNLPSSALAGEAFVWCASPADVT
                     FV"
     misc_feature    complement(15459..15461)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15491..15973)
                     /locus_tag="K6K39_RS40395"
                     /old_locus_tag="EASAB2608_08281"
     CDS             complement(15491..15973)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08281"
                     /product="hypothetical protein"
                     /protein_id="WP_094375418.1"
                     /transl_table=11
                     /translation="MPLPSGSWASLKGEEQKQARIQWTEAGGIALLPCGGLFSAVRAPA
                     HLVWAAADTEELPVVDAFLRQWFDGGAAFADLHALLSYFLVPSSTAWKWTDRHLPGVEY
                     LGRDHYLGVPAVHLTEPQGRGYWCLPMDSAGDLCYPAVVEKLLHHGRATRSGVNAQ"
     misc_feature    complement(15965..15967)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16391..17176)
                     /locus_tag="K6K39_RS40400"
                     /old_locus_tag="EASAB2608_08282"
     CDS             complement(16391..17176)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08282"
                     /product="hypothetical protein"
                     /protein_id="WP_221335527.1"
                     /transl_table=11
                     /translation="MRLSSRFAALAGAALTVAALVGSTPASAGAVPYRAGDGGHNAHGQ
                     WQRAGEYLNLHQCVYFPRVPAGAQRFTTLVPSRDGRFATGTNISTTQDPQGQPSCGPGN
                     GNFELSLAESKVLGVDLTAGRYLNLHQCVYYNSFTRDHFTVVVPIDTDFSAGTNVSNTP
                     DTAPSCADGNGIFQLIPLLSGVKALDQNTGRYVNLQQCVYYSDSHADHFTTVVPSRDGR
                     FATGTNISNTPNSTPSCGRGDGNFLPIPLLSGVKALPLT"
     gene            17597..17731
                     /locus_tag="K6K39_RS41620"
                     /old_locus_tag="EASAB2608_08283"
     CDS             17597..17731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS41620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08283"
                     /product="hypothetical protein"
                     /protein_id="WP_260336081.1"
                     /transl_table=11
                     /translation="MAAVADALPYGFASAALAELQRLVDDVLHVEGYAVAPRWEQPGG"
     gene            18033..18821
                     /locus_tag="K6K39_RS40405"
                     /old_locus_tag="EASAB2608_08284"
     CDS             18033..18821
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388484.1"
                     /locus_tag="K6K39_RS40405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08284"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_086703970.1"
                     /transl_table=11
                     /translation="MAGYGALSNVYEWLIGDDRLTPAKAAAVYYSDVVGSLPPNARVLD
                     CACGTGQLAVGLASLGLDVVAADASDGMVRRTEKAADEQGVSLRALRASWDELPDRLED
                     STFDLVFCVGNSLGHAEGAAGRLTALEAMSRLLNPGGRLVLHSRNWELVRSAGSRVDVR
                     DRLIRRDGRDAVVSYYWQIEQCWEQEHFLEIVVAQIEPDGAVRACSERLSIWPYRYEDL
                     VAQLRSVGLTVQSTTFAPESDGYLVVASRDQARGTSEPVR"
     misc_feature    complement(18072..18085)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(19817..20173)
                     /locus_tag="K6K39_RS40410"
                     /old_locus_tag="EASAB2608_08286"
     CDS             complement(19817..20173)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981889.1"
                     /locus_tag="K6K39_RS40410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08286"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_094375414.1"
                     /transl_table=11
                     /translation="MNPTATLTCRHADGDLAVASVTGELTYETMSVVRAQALDLIQRGH
                     RHLILDLHQITFCDSSGFSTLVGIWRYAQQAQGTVVLAAVPDRLSRMLALTGLDELLLA
                     YPTTEEALAAHRSP"
     gene            complement(20170..21609)
                     /locus_tag="K6K39_RS40415"
                     /old_locus_tag="EASAB2608_08287"
     CDS             complement(20170..21609)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006136360.1"
                     /locus_tag="K6K39_RS40415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08287"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_260336082.1"
                     /transl_table=11
                     /translation="MPQPNHAARWGNDPRQAAPGAAEEAARMDAVRRYDILDTPPNGAY
                     DRVAAMAARLFKVPVATVTIVDEDRIWFKATHGLDGVSEISREPGLCGSAVLADDTLVI
                     RDTLADPVACRNGLVTGPMGVRFYAAAPIVTHDGHRLGTVNILDVKPRSVTEEDTRTLA
                     DLAAIVLDELELRLAALNSLRAEQERRREQEEARARAEADKASVEAFAATLQRTLLPPA
                     LPAISGMELSCHYATASPRHVGGDFYDVFPLDGGRWAFFLGDVCGKGPEAAAVTSLTRY
                     TLRAAALIDPDPDTVLHALNSALLLDPAVGTRYCTAVFGILTPATQGCFTVTVATGGHP
                     PLYHVRNHAARRLADPVHPKGGMLIGALPEARFACHTFTLAPGEALLLYTDGLTEARAQ
                     DGTMIGEDGLARFLTGRTRPASATALIEDTVELIDTLPQGADDDVALLALSIPAPGPAA
                     DNVTPTAHTTAPTGPQPKSRP"
     misc_feature    22257..22272
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 gcacaccggc cgcgccgcct tcgacgccgc gctcaacacc gtcaacgtcg gcaagttcaa
       61 cctgtgcacc gcctcgatcg gcatctgtga gcacgcgatg tacgaggccg tcacccacgc
      121 ccacaaccgc atcctctacg gccgccccgt caccagcttc ccgcacgtgc ggcgcgagct
      181 gaccgacgcg tacgtcaggc tcgtcggcat gaagttcttc agcgaccgtg ccgtcgacta
      241 cttccgctcc gccggccccg acgaccgccg ctacctgctc ttcaacccga tgacgaagat
      301 gaaggtgacc acggagggcg agaaggtcat cgacctgatg tgggacgtca tcgccgccaa
      361 gggtttcgag aaggacaact acttcggcca ggcggccgtc gagatccgcg gtctgccgaa
      421 gctcgagggc acggtccacg tcaacctcgc gctgatcctg aagttcatgc gcaaccacct
      481 cctcgacccg gtcgaggccc ccgacgtgcc gacccgccgt gacgcggccg acgacgactt
      541 cctgttccgg caggggccgg ctcgtggcct cggctccgtc cgcttccacg actggcgacc
      601 cgccttcgac cggtacgcgc acctgcccaa cgtgacgcgc ctgcgcgaac aggccgacgc
      661 gctctgcacc ttcgtcacca cggccgcccc cgatgccgag cagagccgcg acctcgacct
      721 cctcctcgcg gtcggtcagc tcttcgcgct cgtcgtgcac gcgcagctca tcctggagca
      781 ggcggccctg acgggactcg acgaggacgt gctggacgaa ctcttcgccg tcctcgtgcg
      841 ggacttctcc gcgcacgccg tcgaactgca cggcaaggac tcggcgaccg aacagcagca
      901 ggagtgggcg ctggcagcgg tccgccggcc ggtcgtggac gaggcgcgta cggagcgggt
      961 ctggcagcgg gtcgaggcgc tgtccggcgc gtacgagatg gccccgtagg cacgccgtac
     1021 acagcaccgg gggccgggcc gcgcacggcc cggcccccgg tgggttcccc cggcctcggc
     1081 tcgccgcgtt cccggcggcg gcgtcgatcg cccgtcccgg ccaccctgcc cggggaccgc
     1141 aagggctcca cccggtcgga cgacaactcc gacggacggc tcatcgcttc ccgttggccg
     1201 tctggtgacg acggacgtgg cggccccggt ccgtcgtgcg gccggtcatc gaggacggct
     1261 gcagtaaccc tgcgggaagg catcccagaa atcctcgtcc acgcccgcgt ccacgagcgg
     1321 gttccagttc gtgtgggcga cgagctggtg gcgcccgtcg cggctgttga gggcgaaggt
     1381 gagatacccg ggtgcgctgc cgccgtggcc gtacgcgagg ccgcagtcag tggcgtagac
     1441 gtacacgccc aagccgtagc cgacggcggg cggggcactg cccgtcgtgg ggacggtgtc
     1501 ggaaagcatc tggcgcaaca gctccggcgg cagcagacgc ccttgcagca ggtaccggta
     1561 gaaccgggcg acatcggctg ccgtggtcac gagagcgcct gatgccccgg cctcggacgg
     1621 gctgatcgcg gtgacgtcga accgggtggc gtccggcgcg tcgggcagca agggggagac
     1681 gtccgcgtag ccgtgtgcat gggctccgtc gatggcggtc ccggccaggg gataggcggt
     1741 gtcacgcagc ttcaggggag cgaagacgcg gcgttcgagg ttggtgcgca ggtcacggtc
     1801 ggtgatgcgt tcgacgatca gatcgagcag caggtaattg gtgttggagt accggaaacg
     1861 gagtgccggg aacagggaag tagcgcggct gggcaaggcc gatgccgatc agctggtcgc
     1921 ggggccagta ctggtcgagc gcgcggaagc ggggaaacag cccgtcgatg tagtcgtaca
     1981 gcccgctggt gtgattgagc agctggcgga ccgtgatggg cgcgccggac agtgcgttgt
     2041 cggcgcggac ctggtcgggc agcagggtgt gcacggtgtc gtcgagtcgg agccggcgct
     2101 cggcgacgag ttgcaggacg accgtcgcgg tgaaggtctt ggtgatgctt ccggcgcgga
     2161 atttcaggtc cggtctcatc ggcgtgccgg tggaccgatc agcgacgccc gccgcgccga
     2221 aacggtcccg cgtgccgtcg cgggcgagga ggaaggcgcc cgggttgggg ttcgggtcgg
     2281 ccaccaccag atcgacgaga gcctgcaggg ccgggtcgcg gcggctgtcg gaggcccgac
     2341 cgtcaccggc ctggcctgcg gtggccatcc cgggtgacag caggaaagcc agagcaagtg
     2401 ccagggataa caggcgggtt gggcgtcgca tcatcgagat cccccttctg ataaccgtat
     2461 ggacgtacgg ttatagcacg cggtaccgtc cttgcgtgcc gagagttgcc gatcacgacg
     2521 cccgccacgg gcagatcacc gacgccgtcc agcgcctgat cgtgcgggac ggcctcaccg
     2581 ccgtgaccgt cgcccgaacc gctgccgaag cgggtatgtc cgtgggcctg gtgcagcact
     2641 acttcacagc gaaggacgag atgctgctgg ccacgttcac ccgcgtcaac aggcgcttca
     2701 ccgcacgagt ggacgagctg gtgaaccggg gcgaagccga gggccgcacc atcgccgtga
     2761 tgctgcggca ggcgttggcc gagcttctac cgctcgacga cacccgccgc gccgaacacc
     2821 tggtccgtct cgccttcgcg gaccaagccg cgcacaacac ccggctcgcc accgtccaga
     2881 aggaaaccct cgcggacatc cgctcacgcg tcgcccaagc catagacaac ggcacggtct
     2941 gcggcgaggt caccggcacc gtcgacgccg ccgaccaggc cctgcgcatc gtcgcgtgca
     3001 cggacgggct cgccctgcac acgcacatcg acccggacgg cacaccggaa ccggcgatcc
     3061 tcgccgccct ggacgaccag atcggccgcg tgttcaccgg aacctgccga cgcgcacggc
     3121 gctgccagga agcctgaagg tgtccggtgc cctcggacag cactttccag tcgcacaact
     3181 ccgaggaccg ccccggagtc gaccggtacc aggaggtgct gggcggcgtg cgtccggctg
     3241 gagcggacca acagtgggcc ggctcggtga gggcggctgg cgtgcaggcc ccgcggcggg
     3301 ggaccgacag cgagtgacgt caggcggagc ggctgacatc gtcgaagtcg gtggaggccg
     3361 acagctcggc ccaggccagc atctcgcgct cgaaggcgtc gcgtccggcc cggacgagcc
     3421 gaagcgcgtc ggtgccgagc agtaggcgcg tcggcggccg gtcggccgcc acgatgcgca
     3481 gcaccgcggc cgcggccttg tccgggtcgc ccggctggcg cccgctgccg tggatacgcc
     3541 gggcgcgcag cggctcgaac aacttgtcgt agtcggcgat cactcggggt gcgcggacca
     3601 tcgagcggcc ggcccagtcg gtccggaaac tgcccggctc gacggcggtg acatggatgc
     3661 cgaagtcggc gacctccttg ccgagtgttt cgaggatgcc ctccaccgcg aacttgctgc
     3721 cgtggtagaa gctgagaccc ggcatggtga tcagcccgcc catcgaggtg acggcgatga
     3781 tgtggcccgc acggcgctcc cgcatgtgcg gcagcacggc cttgatcacc gccacggttc
     3841 cgtagacgtt cacctcgaac tgacggcgaa ggtcatccat cgacgactcc tcgaagaggc
     3901 cgtcatggcc gtacccggcg ttggcgacga gcacgtcgac cgggcccagg tcgcgctcgg
     3961 tctcgcccac gaccctgtcc accgcgacat ggtccgtcac gtccaggacg cgagcgtgca
     4021 cgtcaccggc gagcgcctcg aaggcccgtg cgtcggcggg cgtgcgcacc gtgcccacca
     4081 cccggtgacc cgcggccgac gccgcgcgcg ccagtgcgcg ccccaggccg gtactgacgc
     4141 cggtgatcag aaaagtcttg gtgtccgaca caggagttcc cttcgtgcga tgcgaacaga
     4201 agccggccgg ggcggtgggg ccccggccgt tcccgacgcg ttccacttca gcaccggaat
     4261 cggctgctga tcgacttctg ggggcccgct gctccccggg gatgaccgga ccgggggact
     4321 gccagtcccc ccttcacggg ccgtcggcag gatctcgggc cctatcgtga acggcatgga
     4381 ccgcaacaca gctctcggcg agttcctccg ctcccggcgg gcacggatca ccccgcgcca
     4441 ggcgggcctg cccgacgacg gcggccctcg gcgagtgcca ggactgcgcc gcgaagagat
     4501 cgcgcaactg gcgggcgtga gcgtcgacta ctacctacgc ctggaacgcg gacgccggct
     4561 gaacgtctcc gagaccgtgc tggacgccat ctcccgcgcg ctgcgcctcg atcccgtcga
     4621 acgcgcccac ctgttccagc tcgccaagcc cgccgcaggc aggccccgcc gcacggcgac
     4681 gcgtccgcag ccggtccgcc cggggctgcg cgacctgctc cggatcctcg agcacacccc
     4741 cgcgctcgtg ctggggcgcc ggctggacgt ccttgcgtcc aacccgatgg cacgcgcgct
     4801 gctcaccgac ttcgacgcgc tgccgcaccg cgagcggaac ctggtccggt tcatgttccg
     4861 cgacgacacc gcccgctcgc tgtataccca ctgggacacc cacgcccagg acatcgtcgc
     4921 ctcgctccgg cgggacgccg gacgccatcc ccacgatccg ctgctggccg aactcgtcgg
     4981 cgaactctcg atcgcggacg aggacttccg acgttggtgg gccgaccaga acgtgtatcg
     5041 gcacacgcac ggcagcaagc acttccacca cccgatcgtc ggcccgctca ccctccatta
     5101 cgagtccctc accctgcccg ccgacccgga ccagcggctg agcgtctaca ccgccgaggc
     5161 aggctccagc tccgaagagg cgcttcggct actggccgcg tggatacggc agcccgagac
     5221 ctcgcacggg cggtccgcag gccatcggac acccgccggt ccgtgaggag cggccggccg
     5281 cagtggccgc gtcccatgag ccgggtcggg cgttacgcgg caccggcaga ccgcgcgccc
     5341 cgcggccctg cacttcctga taacggccct gcactccctg atacgggaag ggcgcgaggg
     5401 gcgtcggccg ggttgctcct cggcagaatg agccacatgg ccgtagacaa ggacgcagcg
     5461 ttcacactgc cgcgaggcgc cacgggcttc ttccagccga aggacgggcc gctgccggaa
     5521 accgacctgc ggacgttccg cgcggcgctg catgcagccg ctcgtgcggc cgaaggccgt
     5581 gtgggtgaga cagaggaaca gacgtatcct cgtacgttcc acacggcgac ggtcatcgag
     5641 ggcacaggcg agtgcatcat cctgtgccac gcccaccacc cctggatcgc gttcgcccag
     5701 gaacgccgtg actggtacac cgaggagttc ctcgcaccac ccccatgggc ccacaccttc
     5761 gccgacctgg gattcgtggt gctcgaccgc gcgcagctca ccctgccgct ctcggacatc
     5821 gacacgtcgg tcctcacccg ggccgaatgg cgccagatcc gctcctacgg catcaccaca
     5881 ttgggcggag tgctgttcaa cgcatgggac tgacgtcgag gcaggaatcc atggcggaca
     5941 ccacaaggtg gggcggcact ggtgtccacc tgcggggttc ggacgcgtgg cccggcacat
     6001 tcacccggat gacacacact gctcgctcag gctcccatca tccgcggacg atgggagcct
     6061 gagcgagcag gcagagagga ccgcccatga ccacggccgc cgacatcatg catcccggag
     6121 cacagtggat ccccgccaac gaaaccctgg accgcgccgc ccagctcatg cgggaactcg
     6181 acatcggcgc actacccgtc gccgaccccc aggaccccaa cgaacgcatg tgcgggatca
     6241 tcacggaccg ggacatcgtc gtcggctgta tcgcttccgg gcacgatccc gcgcgggtca
     6301 ccgcggggga actgtgcaag ggcaccccgc gctggatcag caccgacgcc agcgtggacg
     6361 acgtgctgca ggaaatggaa tccaaccaga tccggcgcct gcccgtgatc gacggcaaca
     6421 agcgcctcgt cggcatgatc agcgaagccg acctggccca tcacttgacc gacgatcagc
     6481 tcgcgcaatt cgttgagcgg gtgtacgcct gaccgctacg catggacccc ggggctccgc
     6541 gtccgcgggg tgcggtgcgt gctgcacatc gttcctcagg cggcgccgag gaggagatcc
     6601 acggcgcgtg gacgaccgag gagccggcct tcccgaccac cagatcagcc atggaacgct
     6661 gcacgagccg gcggtctcgg agcagcgggc gtacgggcac gatccacggc gtgcgggagt
     6721 caggagctgc gcggagtcac caggccggat tcgtaggcgg ggaccacgag ctgggcgcga
     6781 tcccgggcgt ggagcttggc catggcccgg ttgatgtggg ttctggcggt cgccgggccg
     6841 atgatcaggc ggtcggcgat ctcgtcgttt gacggaccgt gtgcggccag ggcgaccgcc
     6901 tcgcgttcgc ggctggtcaa ctcctccagc gcgctgccga tgcgggcggg cggcggctgg
     6961 gcgacatagc gatcgatgag cttgcgggtg agggcgggcg cgagcagggc gtcgctccgg
     7021 atcagcaccg gcaacgcgcg caccggcggg atggcgccca tcgcggtggg agcggtcggc
     7081 acggttctcg cggtgctgca cctggccacc gccagcggcg gtcccggcac cggcaacgga
     7141 ctcgtcggcg ccgtcgtggc cgtcccactg ggctgggcgc cgtactgctc ggccgccggg
     7201 ctctgacccg cggccgcccc gtcgaccgtc ccgccgcccg ccccgcggac cgtctcgccg
     7261 accgccccgc cgatcgggcg accgtctgac cgccacccgg tgacgacgtg cgtgcggcta
     7321 ccgcgcgccg gatttgccag gtggtgagac cgatggccgg caccgcactc cccgagatca
     7381 ccgaggacag gggcgggcga aggtcaggag caggcagccg gccagcccga cggtcgggag
     7441 gaccgcgcgg gtaagcgggc tgacggtccc ttcagccctc ccgtcccggc cacgctcgcc
     7501 accgccctgc aagacaccac ccgccgcccg aacccgcccc tgcacctgac tctcggctcc
     7561 agcgcctacg acgccgtcca ccgaactcac cgaacgcgtc accgcgctcg aagcccagga
     7621 ccatctcacg gcatccgtca cctgcacccg ttgacccggc cggaacagcc ccctcccgca
     7681 ccgccaccgg cgcaccgtgc gtcggcacgc tcccctggct ccgccggagg accccgctcg
     7741 ccccgctcgg ccgacagccg cccgcgacgc ctcacgcgcc ctcgcacacg ctctggtggc
     7801 cgccgttcac cgcccgtgac actggcagcc accatccggg acatctgcac cagatccacg
     7861 ggaaggaaac aaccccccat gcaccgtgtg acgtcactcg ccatcgcctc cctcgcggtc
     7921 accgcggccc tcggcacggc ccccgtcgcg tccgccgccg ccccggcccc ggcgggcagc
     7981 agcgccgccg cggccttccg ctgcgacccg ggatacttct gcatctacag cggctggaac
     8041 ggcggcggca cccgctgcca gtggaggtcg gagagggtcg cgaacaccgc cgacctgtgc
     8101 tccttcatcc gcaacggcag gaacgtgctg tccgtgtgga acggaaccgg ccaccgcgtg
     8161 cagtactaca cgcagaccaa cttcaacgca cgcgtcggat cgactcccgc cggcagcgga
     8221 ggaaacctcc agggcagcta ccagatccgc tccttcaaga agcagtagct ctcccgagcc
     8281 accgacacgg agtctcgccc cctcatcaca tccccctgcg caccgcccgc tgtcccgcgc
     8341 cccgtggcgc gggacgtgcg gcccggggcg cagccgtgta tccggggcgg gcggacggtc
     8401 cgccgtccgc ccaccccgga gccgcatgcg gtgccgcgcg ccgtgctgtg ggagaccgag
     8461 gacggactgc cgcggctcag tggagtggtc gactgggacg gcgaggaact gctcggccgc
     8521 gtactcgctc tcagcggtgg agccctgggc ggtgacgtcc ccggccggat ctccacgatc
     8581 cgcggcacct ttgccctcca gcaggccctc tgcgcccagc gcgacggtga cgaagaggaa
     8641 ctggccgacg ggctgaccgg ctaccgatga gatcggcatg gtcggagtgg gtgtgcaccg
     8701 cgaagtgcac cggcacgttg cccggcacgg gatgcggtgc gctcagtgca gtgagcgcgt
     8761 gagcaacggc cgcgccggtt cgctggttcc ttcaggtggc ggtcggacgg tcttctacgg
     8821 tccgacgcat gctggatccc gaactgccgg tacggctcac cgcgcgctgt gcggaatggg
     8881 agaggtcgaa gaacagccgg ccgagcagtt ggcggaggta cggccgagcg ggacgagctc
     8941 gccgacgagc gcgcctcatc cgcacccgcc acgccgacca ggacatcgcc cggcggctga
     9001 ccggcgacat cccaactggg cacctacaca agtttcccgc ggcctgaacc gaccggcccg
     9061 attcccgcgg aggcagagag ctgacccggg aaacgggcga gggacatgcc cgtccggcgg
     9121 acggcggccg taacgcggca ggcggggcgg tcgttgtcgg ccaggtaaca cgtcatgtcg
     9181 gcacaccggc actttccctg ctacaggagg tcgttcaccg tgtccttgag caagagggca
     9241 atcccagtcg tcgcggccgc ggccgccctg gtggtctgca ccgccaccgc cgcgggtgcc
     9301 acctcggtca tcggtttcgg taacggcacg cacgacaacc ggtgcgccaa tcacggatcc
     9361 acctacaccg tgaactccgt gcggcatacg gcaggaagcc tggtcgcagg ggtgctcgcc
     9421 ttctctctga gcgccccggc caatcagtgc ggtgacctgg gcctgcccaa ggaggacaag
     9481 gtcgaccagc ccgcggagaa cttccacgtc gacgtcgccg agtgaggggc cggcgcgcta
     9541 tcgcgcggct gccccgtgcc cgacgtacgc ccggcgtcgt gcaatgaccg agtaccgcga
     9601 cgccgtcatc tccggcgtcg ccgtgctctg aactcgagcg ccgtcgaaga cactgtcatg
     9661 tgtgctgggt atgcccaagt gggcattccg gtgtgtcggg agttcagtcc caggagacga
     9721 ggctggacag ggcgatgccg gccgccgcga taccggccat ggcgatcagg aacacgatcg
     9781 ccgcgacggc gaacagcaga cacgagcaac cagtactggg cgttcgctcg tcagtgtccc
     9841 attgccgacc agtcatccac cctgccgttg acggaaactc tgcgtgcggg cgtagcagcc
     9901 tatcgtgggg cggggttggc gggagcgggc ttgatggtgc gggggtgggg gccccggtcc
     9961 tctgcgtggg acggaggccc ggcgggtgcc tgctggcgat tcagcgtagt ccgaggcagg
    10021 ccagccaggc acggggagtt ttgcgggtcg cggtgaggag ggcggcgagg gtgcctggca
    10081 ggccgttgag gaggtcggtg ggccaggcgg agagcgggtg ggaggcgagg tggtgggtga
    10141 ggtggtggac gaggcggtgt ttgagtgggg tggcggccgg tagttctgcg tggtggtcga
    10201 aggcgtcggt gacggcgagg acgcctgcgg cgccgtggca gagcccgagg cggtcctggg
    10261 gggtgtcgcc gtagaggtgg aaggtctcgt cgtagtgttc ggcgagggtg gtgaaggcgg
    10321 ctgcggccca gtcggcggtt gcggtgtcgc cgagggcgtc ggcggcgtcc cacagtgccc
    10381 aggcgatgcc tggggtgccg tagcaccagg cttggcgcgg gtgggctttg gggttgggcg
    10441 ggtggtcgag tccggcggcg ggccaggtgc ggatgcctcg ttcgtcgtcg taggcctggc
    10501 ggatgagcca gcgggtggcc cggcccagtg ctgtggtcag gctgtctacg aggtcggggt
    10561 cctggtcggg gtgggtgtgg cgcagggcgg tggtgagtgc ggtgacgacg ccggcgacgc
    10621 cgtgtcccat gccggtgttg atgcggccgt ttacccatgc gaggtggggg tgaccggcgt
    10681 agtgcccggt gcgtagtcgt ggcagttctt cgtcgtcgca cagcagcgcc aggtgtgcgg
    10741 cgagcgcgcg cggcgggggc tgtgccgccc cggccgtttc gaaggccccg actgcgtcgg
    10801 cgccttgagc tgtgccgttc gggtcggctg tctcggtggg gtcggttgcg cacagggcga
    10861 ggagggtgcc ggcgggaccg gagatcaggt cgtagtcggg gaaggtgacg gtgtgggtgc
    10921 ggtagcgggg cgggcgttgg cggaggtgtg cggcgaggcg gttggctgcc gggtggagta
    10981 cggggtggag gcgggcgccg aggtgcagac cgatgagggt accggcgagg cctccgtcgt
    11041 agagggcggg gtgggagggg ccgcgtccgg cggtgcgggc ccaggtggtg atggcgttga
    11101 tggccgtctg tgtgtcggtg accaggtggg cgaggagggg gatgccgggg tcgcacgggt
    11161 gtccgctgtc gcggggggag gtggcccact gccgtaggta gtgcacggcg aagtcgtggg
    11221 tgtcttcgag cggggtggcg ggtgtggtgg cgtggtgggt catggtcctg gtggtgtggc
    11281 ctgtgtgggt ggagccgccc ctttgtgggg gcggctcggt ggagttgggg tgggttaaca
    11341 gatgacgacg gtgccgcaga cgacgatggt gcacaggccg ctgcagcctt cggtgtaggc
    11401 ggcggtggcg gggaggtcgt cgtgggtgat gcgttcttcg aggtcgctga tgagggtgtc
    11461 gagttcggtg agttcgttgt ggttcatggg tttctccttt tgggattggt ggggtggggt
    11521 tcgtcccggt ggtccgccgg gtgggcgggt ccggggacgc ggggtggggt gccgggtgcg
    11581 aggaggggcg gcggtgggtt gtggtgtgtg ggtcatggtt ggtgtgtgtc ttcgtggtcg
    11641 tgggtggtgg tggcgagtgc ttcggtgagg aggcattggg tggtggtggg gagtgcggct
    11701 cggttccagt ggaagatgac gtggtgggcg gcggcgcggc gggggccggt ggtggcttgg
    11761 gtggtggtga agtagtgggt gtgccagtgt tgtgcggctt gttcggctgt ctgggtgtgt
    11821 gtggtgatgg tgtggtgcca ggcggggggg agtgtgtgga ggcgggtggt gggggtttgt
    11881 tcccaccagg cgcggattcc ggcggcggcg cgtcggcggt cgggcgtgtt gagtccgcct
    11941 gggaggcggc ggccggtttc ttctttgacg gtctgccaga ctccgcggtg ttcccagccg
    12001 gtgatgtgca gggcggtgaa cacggtgtgg agcagggtca gggacaggcg ccaggcgggg
    12061 ggtgggggag tgccggcgtg gtgtgtgtgg aggtcgagcc aggcaaggga gtcggcggtg
    12121 aacagtgcgt ggacccaggg catggaggcc gggccgccga agaggtaggt ttcgggttcg
    12181 tacacgccgg gcgtgggcgg gggccagggg tcttgtccgg gtgccgggtc caggcggcgt
    12241 agcagttctt cgcgcaggtg tgctgtctgg tcggggtcgg ctgcctggaa ccgcacgcgc
    12301 aggccggggg gtttgtgcat gaagaagaag ttgctggcct gtccgctggt gaggagttct
    12361 cgggcggtgg tggcgagccg gtggtagggc ggcgggccgg ttcgggaggg gtggcgggcg
    12421 aggttgagct gtacccatcc ggtctcgcac gggtgggtgc gcagggcttg caggccggcg
    12481 gtcaggaagg tgcggcgggc tgccgggtag ccggggtcct cggctgagac cgggacggtg
    12541 cccagcggct gggtacgtgc gtcgtccagg cagtcggcca gcagacgctc caccgggatc
    12601 atgcggtctc ctcaggcgtt gaagacggac gccacctgtg tgatgtccgg gccgccggtg
    12661 ttccgaagca cgacaatgga ttggtcatat gatcaacagg agtgcgcggg aggtatgccg
    12721 cctgccgtga agcccggccg gcgcgccggt ctcccaccgg cgccgcccag ccgtcccccg
    12781 ccctgctggc cccgatcctg gcctcggccc tggtgctggc ccccccgcct tggtgctggc
    12841 cccggccccc gatcccggcg ctggcctccg gcccccggtc ctggtcccgg cccccgccct
    12901 ggcgttggcc tcggttccgg tgctggtgca ggttgccggg ccggcgcctg cgcctgggcc
    12961 ggccggtgac ggggtcctgg tcggggagac tggcgggctg cgggatccgg tgtggggcag
    13021 gtgttctgtg ggcgggcagg gatgtgttta cggaagcacc agccattcac tcatgcccac
    13081 tgagtgcgcc cgctcagcta ggagctgtcc ggccgatcat cggatgcgta cccttggctc
    13141 gtgactgatc acggcattgc tctgcctcac taccgcctcc atgtcgtacc tgcggtcgtg
    13201 gcattggcca gcccgacatg gcagcgagag gtgtggctcg atccggatca gttcgaggac
    13261 ctcgactaca ccgtccacgt gctcttcgac gacttctgcg atgcgaacaa tcctcggccc
    13321 tggcttgggc agtgccttcg cagcgaggag gaagtcgagc tgatggcgcg tctcggtgct
    13381 gcctacggcg cggtacagga ttcggtcggc gccgcggctc ggggcgaggc atacctggac
    13441 tcgcctggct ggtctgctgt agtcgccgcg gcagcccggc tggcccaggt gctggtggcc
    13501 aatgaccact tggcgttgag caagttgcat gacgccggcc atcgctggcc gctcgacacc
    13561 aagccgatca tgagatcggc ttgccgcggg cccgtcgccg aatgcgagcg atgcggtccc
    13621 agcgggcgaa cgcggtgatc aggcggcgat cctccagatc cttgatggcc gcggtcttct
    13681 gttcgatcca tcgctccagc cgggccaggt actcgtccca caccggaagg atgccggcgg
    13741 agaccaggac ggctcggaag tagtcgaccg ccagatcccg ctggtggctt atgcgggcgt
    13801 cgagggcttc gtggctgagc tcacaggtcc cgacggcgag gtcggtgacc agacgggtcg
    13861 ccgtggctga ctcacgcaga cagagcaagg tccggcgggg ggtgaggtcc agcagggcct
    13921 tcgcgacctt ggtcgagctt gggacggcgt tggccgtcgg gtggcgtcag cagtgtccgt
    13981 agctgtcgtt cgcctgcaca tcggcggcag agcccgaagt ggaaccgccg ctcgaccgtt
    14041 ctgcactgct ggcagggttc ttgagcctcg ggggccttct cccagcagtt ctcgcagatg
    14101 ggtccccgtg cggccctggc ggtgacgcgg gaggggcgtc cacagtcggt gcagggctcc
    14161 tgcttgatcg agcatgcccg gcaacggggg gagtctttct tggcgaacat gcagccgcgg
    14221 agcttgccgc aggagccgca ctgggcgacc ggcggtttga ggcagactcc acagagcggc
    14281 ccgtcggcag tgcgggcggc aacggcacag agtcgaccgc agacaccaca ttcttcctgg
    14341 taggcgggct tctctcgacg gcacttgatg cagatcgggg ctccgtcctc gtcgcgaccg
    14401 gcggccgggc gatgacgtcc gcaccatttg cagggctcgg ccttcgcgcg gttgtagcag
    14461 gtcccgcaga ctctcatccg cttgatcgag tgcgtcagcc ggtccgcgcg gtcacagtgc
    14521 ggacacttcg gcgccgaaac gccctcggct ccgacccggt gcagccggtc taccagcagc
    14581 acggtccgcg gcgagtagtg gggagcctgc cccatcagga ggcccggctc attctggaca
    14641 tcccagagca gacgacgagc ggccggggcc tgccccccgg ttacctcagc gatcaccgtc
    14701 tggagcacgg tcttcgagcc cgaggccgga caggtggctc agcaggtcgg cgaccgggtc
    14761 ctcattgcag tcggacctga agcagaagcg gcagacctgg cggccgaagc ggtccagacc
    14821 gtagcgcggg gtctcgccgt tgccgcaagc cctgcaggac cagcccgttg cccggagtct
    14881 gggtgggccg ggataacgtc gaagcactcc tcgcaggagc cgaccgtccg tagacgtact
    14941 ggcgcagagc acttgttccg tggctgtcgt attcctgcgg ccatgctcac gggccgggga
    15001 aggttcgctg aactctgcgg taaagccgcc gaattggggc cagggaacct tggggcatgg
    15061 gttgacggca tggtggaggg ggcgaactcc gcggctcaga ccatgccgca ggagcagcag
    15121 acaagggggc ggcatgccgc ccggcggaag aaggacaagg gcggactggc tcgttcgccc
    15181 ttgctgatgg ctgttggcac ggtggtgtca cgggcgacgg gactgatccg ccaagtgctg
    15241 caggccgcag cgctgggtac gtgccagtcg taccaggtga tgtaccaggc gaccctgctc
    15301 gtgtagcagg ccatgcagcc ccaccgggga agttccaccg acggctccag ctacacgaag
    15361 gtcacgtcag ccgggctcgc gcaccagacg aacgcctcgc cggccagggc cgacgagggc
    15421 aggttcggcg gcacctcgaa cctgctgacg agccggtgta agcgtgccag ctcttcggcg
    15481 atctgcacgg tcactgggcg tttaccccgc tgcgggtcgc acggccgtgg tggaggagct
    15541 tctccaccac ggccgggtag cagaggtcac cggcggagtc catcggcagg caccagtacc
    15601 cgcgtccctg gggctcggtg aggtggacgg cgggcacgcc gaggtagtga tcacggccca
    15661 ggtactccac gccgggcaga tgccggtctg tccacttcca ggcggtggag gagggcacca
    15721 ggaagtagga caggagggcg tggaggtcgg cgaatgccgc accaccgtcg aaccactgac
    15781 ggaggaaggc gtcgaccacc ggcagttcct cggtgtcggc cgccgcccac accaggtggg
    15841 caggggcgcg gacggcggag aagaggccac cgcacggcag aagcgcgatc cctccagcct
    15901 ccgtccactg aatgcgggcc tgcttctgct cctcgccctt gagcgacgcc caggagccgg
    15961 aaggtaacgg caagctgccg ttccggaagg gtggtgacgt gcccttcctt ggagggcgac
    16021 gtgccgcgtc ggttcgtccg ggatgggagt agctacggac tccgatcgat catcgggata
    16081 cgtgctctgg tcactgtgct accccctccc cccaatcggg gatacgtgga gttggtcgtt
    16141 tgcgaaggtg atcctcgatg aggcgggcca gtctcggcgc cagcggggac gtccgctcat
    16201 cgcccccttc cagcactgcg gctccgtgat cggcgaccgg tgtgccccac ggggacgtcg
    16261 ctcatcacca gagcagaggg ctcgccgccg ctgcggtgca ctcgcggggc tccgccgccg
    16321 gaagccgacc ttggtgaccg ccaggtggag gtggaggggc ggggtggctg tgggcctgcg
    16381 cggccggctg tcaggtcagg gggagcgcct tgacccccga cagcagggga atcggcagga
    16441 agttcccgtc acctctgccg caactcggcg tactgttagg ggtgttcgag atgttcgtgc
    16501 cggtcgcgaa ccggccgtcg cggctcggca ccaccgtcgt gaaatggtct gcgtgcgagt
    16561 ccgagtagta cacacactgc tgcaggttca cgtaacgacc cgtgttctgg tccagcgcct
    16621 tgacgcctga caacaagggg atgagctgga agatcccgtt tccatcggcg caggacggcg
    16681 cggtgtcagg cgtgttggag acgttggttc ccgccgagaa gtcggtgtcg atcggcacca
    16741 cgaccgtgaa gtggtcacgc gtgaaactgt tgtagtacac acactggtgc aggttcagat
    16801 agcgtccggc cgtcaggtcg acgcccagga ccttcgactc cgcgagggag agttcgaagt
    16861 tcccgtttcc cgggccgcac gacggctggc cctgcgggtc ctgggtggtg gagatgttcg
    16921 tgccggtcgc gaaccggccg tcgcggctcg gcaccagtgt cgtgaagcgc tgcgcaccgg
    16981 cgggcacccg cgggaagtac acgcactggt gaagattcag atactcaccg gcccgctgcc
    17041 actggccgtg agcgttgtgg cccccgtccc cggcccggta cggaaccgca ccggcggagg
    17101 ccggtgtgct gccgaccagc gcggcgaccg tcagtgcggc accagcgagc gcagcgaagc
    17161 gtgacgaaag acgcatgagc ccatcccctc tctcttgtgc cgcctccccg acatatgcgg
    17221 cggagtggtc ctcattcgag agactgcccc cgtgatatca ccccccggcg atggcccgag
    17281 aacttcaccc catcgagtgc atcgccctat ccgggagggg gtggcagggg gggcacgctg
    17341 gaggctgttg tggccaagcc gccgcggatg gccgccctgc gggagcggcg tggcggtgaa
    17401 gtgcggaggg caggctccgg cggcgaccac gaccaagacg ccgaggcatc ccgttcgctg
    17461 ccgtccgagc gccgcgtcgg caccctttga gggcccgcgg aagaccggct gggatgcttc
    17521 gtcgtcaccg gcccggatgc ggccgaggtg gaacagcgag ccgacacgct cgcgcggtag
    17581 gtccgcctcc gagctgatgg cggccgttgc cgacgcgctg ccgtacgggt tcgccagcgc
    17641 cgctctcgcc gagctgcagc gcctggtcga cgacgtgctg cacgtcgagg ggtacgccgt
    17701 ggcgccccgc tgggagcaac caggtgggtg attgcattcg ctctatgcgg cttcggcaat
    17761 cagtttggat ggctgtgcct aaagcgctcc gcagtgaacg cgcgcttgcc ggccgcggtc
    17821 cccgtcgtgg ccgatggggc gccggtggag tggggacctg cgacggtccg gcgtgtcgcg
    17881 gtttcccacg aaatccggtg gagcctcggc ggccggacgt ggttgggtcc tgctcaatgc
    17941 tgcgctgaca cggcccggca cagtgcgagg cgcaaggtcc gaatcgcagg cgcggtctag
    18001 cccgcgtgtc gtcgagtgat ggaggtatcg cggtggctgg ttatggggcg ctttccaacg
    18061 tatacgagtg gctgatcggg gacgacaggc tgacccccgc caaggcagcc gcggtttact
    18121 acagcgatgt cgtgggctct ctgccgccca acgcgcgcgt cctcgactgc gcgtgtggaa
    18181 ccggccagct cgccgtcggt ctcgcgagtc ttggccttga cgtggtcgcc gcagacgcca
    18241 gcgatgggat ggttcgccgg accgagaagg ccgccgacga gcagggtgtc tcgcttcgag
    18301 ccctccgcgc gagctgggac gaactgcccg accgcctgga ggactccacg ttcgatctgg
    18361 tgttctgcgt cggcaactcg ctcgggcacg ccgagggcgc agccgggcgc ctgaccgcac
    18421 tggaagcgat gtcgcggctg ctgaatccgg gcggacgcct tgtgctccac tcacgcaact
    18481 gggagctcgt gcgctctgcc ggctcacggg tagacgtccg cgatcgactc atccgccgcg
    18541 acggccgcga cgcggtcgtc agctactact ggcagatcga gcagtgctgg gagcaggaac
    18601 acttccttga gatcgtggtc gcgcagatcg agccggacgg ggcagtgcga gcctgctcgg
    18661 agcggttgtc catctggccc taccggtacg aggacctcgt ggcacagttg cggagcgtcg
    18721 gactcacggt gcagtccacc accttcgccc ccgagagcga tggatacctg gtggtcgcca
    18781 gccgcgacca ggcgcgaggc acgtctgagc cggtgcgctg atctgccttt cgtcgtcgtt
    18841 gccgacctgc cagctcgcga ccgcctgcag cgcttcgcga agtgttcagc gcctgaagcg
    18901 gttgctgcgg gtgcggtcct caccctgcat ctgacctgct ccagctgagg ttggaaacag
    18961 ctcgcgatct gccttaccgt cagctcacgt cagcggctgg ggaattacgt gaacttccgc
    19021 ctggggaatt acgcgatcgt ccacactcgg ggcgcttgat cttctcgaag tcctgtgtaa
    19081 tcagacgttc gcgtcctgac aggacgtcca ggtcattcac ggccttgcgc aagagaggtt
    19141 tcagttcttc gaaagttggc ccggacggct gcccgatctt gtcggcggcg gaattcagtt
    19201 cgtacatgga gtctctcgaa cgattgatcg cggtgataag ttcggtatac cgctggtcgc
    19261 agacggcgtt ggcctccttc gtccagtcag cgagggtgaa gggggctggg cgtagcgatc
    19321 cttgatcagg agtaccgccg tcagaattcc ggccgggctt gcagcgacgg caatccatcc
    19381 gccgaggcgc cgtggcagcg tccgacgcaa ctgccgattg ttgtcgctcc tgtgctcgcc
    19441 tcgcacaagc gatggatgcc agtgctgtgc gccgatgact acgaaggcgc aaccatttcg
    19501 cccggatgcg tcaacggcgc ggaacacggc gagtgaccgt cgccggacct gcccggctgt
    19561 gtcgatggcg acgggcccca gccgcgcctc gtgaccgcgg ttgagaatcc ggctcgcccg
    19621 gcgtcccggg ccagtgccgc ctcgacgcta tggccggccg gtctccgcgg gcagggtgca
    19681 cgatgtcgcc tcgtgcgccc gggccgcggc cgccgaacag ctcctggtgc cgctccccag
    19741 tgcggataac ttccgagcgc tgcgccgctg tcgcaagtgt ctcgtaccgg ccccgctcac
    19801 cacgacgtct gaggggtcag ggggagcgat gggcggccag ggcttcttct gttgtggggt
    19861 aggcgaggag tagttcgtcg aggccggtga gcgccagcat gcggctcagc cggtcgggaa
    19921 cggcggccag cacgacggtt ccctgggctt gttgtgcgta gcgccagatg ccgaccaggg
    19981 tgctgaagcc ggaggagtcg cagaaagtga tctggtgcag gtcgaggatg aggtggcggt
    20041 gtccgcgttg tatcaggtcg agggcctggg cgcgcacaac ggacatggtc tcgtaggtga
    20101 gttcaccggt cacgctggct acggcgaggt cgccgtcagc gtgccggcag gtgagggtgg
    20161 cggtggggtt cacgggcggc tcttcggctg cgggccggtg ggggcggttg tgtgggcggt
    20221 gggggtgacg ttgtctgcgg cagggccggg ggcgggtatg gacagggcga gcagggcgac
    20281 gtcgtcgtcg gcgccctggg gcagggtatc gatgagttcg acggtgtcct cgatgagggc
    20341 ggtggcgctg gccgggcggg tgcggccggt caggaagcgg gccaggccgt cttcgccgat
    20401 catggtgccg tcctgggcgc gggcttcggt caggccgtcg gtgtagagca gcagggcctc
    20461 gccgggggcg agggtgaagg tgtggcaggc gaagcgtgcc tcggggaggg cgccgatgag
    20521 catgccgcct ttggggtgga ccgggtcggc gagccggcgg gcggcgtggt tgcgtacgtg
    20581 gtagagcggg gggtggccgc cggtggcgac ggtgacggtg aagcaccctt gggtggcggg
    20641 ggtgaggatg ccgaagacgg cggtgcagta tcgggtgccg accgcggggt cgagcagcag
    20701 cgcggagttg agcgcgtgca ggacggtgtc ggggtccggg tcgatcaggg cggcggcgcg
    20761 cagggtgtag cgggtcaagg aggtcacggc ggcggcttcg gggcccttgc cgcacacgtc
    20821 gccgaggaag aacgcccacc ggccgccgtc cagggggaag acgtcgtaga agtcgccgcc
    20881 gacatgccgg ggagaagcgg tggcgtagtg gcaggacagt tccattccgg agatggccgg
    20941 cagggcgggg ggtagcaggg tgcgctgaag ggtggcggcg aacgcctcga ccgatgcctt
    21001 gtccgcttcg gcgcgggccc gtgcctcttc ctgttccctg cgccgttcct gctcggcacg
    21061 caaggagttc agtgcggcga gccgcagttc cagttcatcc aggacgattg cggcgaggtc
    21121 ggcgagtgtc cgggtgtctt cctcggtgac cgagcgcggc ttgacatcga ggatgttgac
    21181 ggtgcccagc cggtgcccgt cgtgggtgac gatcggtgcc gcggcgtaga acctgacgcc
    21241 catcggaccg gtgaccaggc cgttgcggca ggcgacggga tcagcgaggg tgtcgcggat
    21301 gaccagggtg tcatcggcca ggaccgccga gccgcacagg cccggctccc ggctgatctc
    21361 gctgacgccg tccaggccgt gggtggcctt gaaccaaatc cggtcctcgt ccacgatcgt
    21421 cacggtcgcc accgggacct tgaacaggcg ggcggccatc gccgcgacgc ggtcgtacgc
    21481 cccgtttggc ggggtgtcca ggatgtcgta gcggcggacc gcgtccatcc gggcggcttc
    21541 ctccgccgcg ccgggcgcag cctgccgggg gtcgtttccc caccgggccg catggttggg
    21601 ctgcggcatc gctcccacac tccttgccgg ccggcccggg cggtcggcac cggtcgcagc
    21661 ctaaaccgtt gctgtttgcc ggaagaagcg gggtcggcgg ccacatgatg gccgccgaca
    21721 cgatcttcac acactgaggt acacgcgcac gctcgtgccg tcgtcgccgg tgtgcacgcg
    21781 caccaggtcg gacacgtagt ggaccagcat cagcccgcgt ccgccgatct gtccgcgctc
    21841 gggcgggcgg cggccggcca gggggtcggt cagccgaccc gcgtcgcgga cctcgatcac
    21901 gacctgtccg tgctcggccc agaccgtcag cacgccccgg ccaccgccgt gcaccacgct
    21961 gttggtcgtc agctccgcga ccgcgagttc cgcatccagc agccgctcac cggccagccc
    22021 caggcgcgcg gcgtgggtga cggcgaaccg gcggaccccc ggaagatcct cagatccgta
    22081 ggagaagacc gaggcgtccg cagcggcggg cggcagcacc tggttgtagc gggagacgac
    22141 ggcttcccag tcgtagacgt cgctggtctc ctcacggccc tggccgtcga tcacggtcgg
    22201 gtgggtgatc cgcgcatcgg ctatcacctg cggatccagc cgcgtctcgt cgtacgggca
    22261 caggatcgtc accgccctgc cctcgaacgc gacgttgatc agggcctcgt gctgcgcaca
    22321 cgccgggtac tccaccgcac tgcgcccggc ccagatcggc tcaccgatga tccgcacccg
    22381 cacctgtggg tgggcgtcgg cgaagccgcg cagcaccttc gggatgatcc ttcccgggtt
    22441 gcggccggcc tcggtcatgt ccaggaacac gatgccctcg gcgtccgcgc ccagcccgcc
    22501 ccggatcagc tccagattgg ggccgggcac cgcgacggcc atcggctcgc ccttggccag
    22561 gccctccttc aggaaggcga ccgtctgccg cgtgtactcc tc
//
