LOCUS       NZ_AP024135            11905 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9175622
            Orig. end                         :: 9187527
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11905
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="40"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11905
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11905
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6905](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6905)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    816..831
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            complement(892..1854)
                     /locus_tag="K6K39_RS39950"
                     /old_locus_tag="EASAB2608_08186"
     CDS             complement(892..1854)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677117.1"
                     /locus_tag="K6K39_RS39950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08186"
                     /product="dienelactone hydrolase family protein"
                     /protein_id="WP_221335506.1"
                     /transl_table=11
                     /translation="MQHPRTSTTAPAHRPHPARPDRPTGRGTLRGSGRLAALAAAVTAV
                     VGLTMLGGPAAHGADNPYERGPAPTESSIEALRGPYAVSETSVSRLAVTGFGGGTIYYP
                     TSTADGTFGAVAVSPGYTGTQSSISWLGPRLASHGFVVFTIDTLTTLDQPDSRGDQLLA
                     ALDYLTRSSSVRGRVDATRLGVMGHSMGGGGSLEAAKTRPSLQAAIPLTPWNLDKTWPE
                     IQTPTLIVGADGDTIAPVATHAEPFYSALPSSLDRAYLELNGATHFTPNTSNTTIAKYS
                     ISWLKRFIDNDTRYEQFLCPLPRPSLTIEEYRGNCPHTS"
     misc_feature    1994..2004
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            2106..2906
                     /locus_tag="K6K39_RS39955"
                     /old_locus_tag="EASAB2608_08187"
     CDS             2106..2906
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192535.1"
                     /locus_tag="K6K39_RS39955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08187"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_221335507.1"
                     /transl_table=11
                     /translation="MTGRTESIESMEQLAVVWRAMVLDRDAEADVRDLPGIAVRWADCR
                     FAFWNCVTLTEVDADAALVARRLSQAAEIMRAKKHPGFLWLFEDLLGDEARGAVRTAAE
                     RAGLAYAFPGTGMAGDLLPLPEPAHPELTFVRVTTEEQLEAYADLNSRAYGFPLEDGRD
                     GLLGSALWKNQVYAYLGLRDGVPVTCAATVEADGRLFVVLVATDPAWQRRGYGEAVTRK
                     ALYEGARATGLTRATLHATAAGAPVYPRIGFKPNSPVRFYSLKE"
     gene            complement(2971..3690)
                     /locus_tag="K6K39_RS39960"
                     /old_locus_tag="EASAB2608_08188"
     CDS             complement(2971..3690)
                     /NRPS_PKS="Domain: PKS_KR (11-175). E-value: 5.4e-11.
                     Score: 34.7. Matches aSDomain:
                     nrpspksdomains_K6K39_RS39960_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020549867.1"
                     /locus_tag="K6K39_RS39960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08188"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_221335508.1"
                     /sec_met_domain="adh_short (E-value: 4.8e-29, bitscore:
                     100.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPTAEPGPTVSLVTGANRGIGHEVCRLLAAHGHTVVLTARSLA
                     HAEEAAEQLGRDGSLVHPLRLDVRDPDSVTAAARDVAERSGRLDVLVNNAAITYDTWQR
                     AATADLGVVAEAAETNLHGPWRTVQAFLPLLRRSGHGRIVNVSSEAASLAGMGGGTPAY
                     TVTKTGLNALTRMLADELRGDRILVNAVCPGWVATDMGGPGGRPVREGAAGVVWAAELP
                     DDGPTGGFYRDGRPLPW"
     aSDomain        complement(3166..3657)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS39960_PKS_KR.1"
                     /evalue="5.40E-11"
                     /label="K6K39_RS39960_PKS_KR.1"
                     /locus_tag="K6K39_RS39960"
                     /protein_end="175"
                     /protein_start="11"
                     /score="34.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VSLVTGANRGIGHEVCRLLAAHGHTVVLTARSLAHAEEAAEQLGR
                     DGSLVHPLRLDVRDPDSVTAAARDVAERSGRLDVLVNNAAITYDTWQRAATADLGVVAE
                     AAETNLHGPWRTVQAFLPLLRRSGHGRIVNVSSEAASLAGMGGGTPAYTVTKTGLNALT
                     R"
     CDS_motif       complement(3562..3651)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS39960_0001"
                     /evalue="4.10E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS39960"
                     /protein_end="43"
                     /protein_start="13"
                     /score="22.6"
                     /tool="antismash"
                     /translation="LVTGANRGIGHEVCRLLAAHGHTVVLTARS"
     gene            3995..4285
                     /locus_tag="K6K39_RS39965"
                     /old_locus_tag="EASAB2608_08189"
     CDS             3995..4285
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670498.1"
                     /locus_tag="K6K39_RS39965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08189"
                     /product="DUF6355 family natural product biosynthesis
                     protein"
                     /protein_id="WP_059256177.1"
                     /transl_table=11
                     /translation="MPVRRLLTAALGSLALTLGLLGAGTATATPAAADPCGFYETGSDA
                     YYNHCTSDGSHVVIKVEVALAPDYERCVAPGRTWLGSAGKIQGAYYVGRTC"
     gene            complement(4307..4975)
                     /locus_tag="K6K39_RS39970"
                     /old_locus_tag="EASAB2608_08190"
     CDS             complement(4307..4975)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129142.1"
                     /locus_tag="K6K39_RS39970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08190"
                     /product="DUF5825 family protein"
                     /protein_id="WP_221335509.1"
                     /transl_table=11
                     /translation="MSTSSTTSPPAVLAWRDYDPAACALPGMFLGELALPGPLEGESER
                     LWRLGARRVRLPATVDLASEGDDERAAAAVGALSLVRDLTARAVLVEWDLRLPPTPDGT
                     WQVLSHLQPPRRIEGPAEAAEALRAWRQGHYLCKCLWRKGPGFVQIRDRRWGELRRFTA
                     DEPHYERAIERLAYGAPADSVPAAVLDDFRGEKLVLEAGPLAWWLPYRISRWLQEPMTI
                     "
     gene            complement(5001..6905)
                     /locus_tag="K6K39_RS39975"
                     /old_locus_tag="EASAB2608_08191"
     CDS             complement(5001..6905)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569705.1"
                     /locus_tag="K6K39_RS39975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08191"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_221335510.1"
                     /sec_met_domain="TIGR03975 (E-value: 2.1e-185, bitscore:
                     616.5, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.1e-10, bitscore: 40.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLVNMPWSPIDLPSLALGILKRSVDERVPGAEAEVLHANLEF
                     TDWITARTPFTGDDYEYYALSSYFMGCGDWVFSSALYDDPHWREEEFTAVMRGKLKKPR
                     MAMTRALHRVVPEFVDEIARRIVAQAPDVVGFTSTFQQNTAALAAARRVKQLAPHIVTV
                     LGGANCDGAQGAAVHRNFPFVDHVVRGEGEAAFPQLLTALADGSDLAGVPGLCHRAADG
                     ASRANPMATRPLPPAAILPPDYSGYFERLAASAARHWVEPKLVVEGARGCWWGEKHHCT
                     FCGLNGSFMQFRSKSPDTFYEEIVELARRHRVLDMYVVDNILDMGYLTTVLPRIIDSGY
                     DLRLHIEIKANMRRPQLRTLADAGMIYVQPGIESLNHRVLDLMDKGVSGCQNVRMLRDG
                     AEAGLSVAWNYLHGFPGETDRDYEPVIAQIPALEHLDPPVDLSARIAIERFSPYFERPE
                     LGFTGLRPEEHYRFTYDLPEEELYDLAYVFEAPERGIGEPTVTALNDALAAWKKHHADA
                     RLTHTDLGDRIVLVSRRRAFDWRTTELADPFELAAFRLLDQPHTVAALTRKAARDAPGA
                     TRDEAGAQRLLDHWLRLGIVFTDGGQYVHIAPAAVNEDLLRLDFMRHTYATRAEPVHA"
     gene            complement(7050..8894)
                     /locus_tag="K6K39_RS39980"
                     /old_locus_tag="EASAB2608_08192"
     CDS             complement(7050..8894)
                     /EC_number="3.4.-.-"
                     /NRPS_PKS="Domain: Abhydrolase_1 (346-507). E-value:
                     4.6e-11. Score: 34.7. Matches aSDomain:
                     nrpspksdomains_K6K39_RS39980_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569707.1"
                     /locus_tag="K6K39_RS39980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08192"
                     /product="S9 family peptidase"
                     /protein_id="WP_221335511.1"
                     /sec_met_domain="PF00561 (E-value: 4.7e-08, bitscore: 31.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.9e-35, bitscore:
                     121.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGYQVYRAALPEVCAADPARMVFTADAGGRCEVFAWDAAAGRA
                     RQVTRRARGTLHGAVDRDAHVWWFDEDAHGAGCWRFQPFTGGPDRPGLTDVPPGLPRGL
                     AVSDHGTVAVAAGDGRATTVHVGPRGGRARTVARLPGHVTLTGITPGGRLLALAGADAV
                     TVLTCDGVVRAVLPGGDTGRLWSLGFAPGPDREELLLIREREDGYVLASWRPGSGPATH
                     DWCAFDTEITARWDPDGRSVLVRQDRHGRSTLHRADLTARTLSPVPTPPGTVLDAATRP
                     GGDLHYLWTAAGRPPRLYSTRGTALPELPALPEPFPGTHRDVWTPGPDGPVHSLLSLPD
                     APRGPVPAVFLVHGGPADHDRDAYDGVVHSLVASGFAVVRVNYRGSTGYGPRWRRAFRD
                     GVGLTQVADLASVRADLVARRLIRADAVGLWGTSWGGYLVLLALGTRPGLWQAGVAVKP
                     VADCAAAYRTTTPALRALDERLFGGTPDEVPERYARSSPIHYAAAVRAPLLVAAAIHDA
                     KCPPGQIRAYLAALRAAGVRHAALWLDSGHDGYDGGDHVTVLRRGVVFLDRELRGPAHH
                     RPQTPRSARSGEHHTAEHLTERRRSRAEGHHPQRPARG"
     aSDomain        complement(7374..7856)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS39980_Abhydrolase_1.1"
                     /evalue="4.60E-11"
                     /label="K6K39_RS39980_Abhydrolase_1.1"
                     /locus_tag="K6K39_RS39980"
                     /protein_end="507"
                     /protein_start="346"
                     /score="34.7"
                     /tool="antismash"
                     /translation="PAVFLVHGGPADHDRDAYDGVVHSLVASGFAVVRVNYRGSTGYGP
                     RWRRAFRDGVGLTQVADLASVRADLVARRLIRADAVGLWGTSWGGYLVLLALGTRPGLW
                     QAGVAVKPVADCAAAYRTTTPALRALDERLFGGTPDEVPERYARSSPIHYAAAVRAP"
     gene            complement(8891..10153)
                     /locus_tag="K6K39_RS39985"
                     /old_locus_tag="EASAB2608_08193"
     CDS             complement(8891..10153)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569708.1"
                     /locus_tag="K6K39_RS39985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_08193"
                     /product="MFS transporter"
                     /protein_id="WP_221335512.1"
                     /transl_table=11
                     /translation="MERPASTARPSHQRAEPRDFRLLWWANAADGVGSQASGTVLPLLL
                     LGLGNSPQTVGLIAGASTALGLLLGPLVALPADRGARKRVMVGSAAVSALAMGCVALAL
                     AAGHPPLGLILTAVLVERLATACFEAAARGTVALVSPGPEQPRAIARLAAADQGALITG
                     PALGGLLYQAARALPFLADALSYLVSALCVAAMRADLRAASPRQRGAGLLREGAAGLRL
                     VRSAPLLRLVLVWGATVNAVVVALYYGAVFTLRRDGHAGAVLGAVLALSGAAGLVGALA
                     APRVAGRFGAPRVVPGVTWLLVPLAAALAVVTSAWAYGLLFGLVCLLMPLASVVLQARA
                     VQVTAPALQARTGAVLATATTGAAALAPVLAGALADRVSAAAPAAVCGVLLALLAAHSS
                     RRPVRGVLAPEAAGRAAEVTG"
     misc_feature    complement(10168..10184)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.87"
                     /tool="antismash"
     misc_feature    10177..10191
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.17"
                     /tool="antismash"
     misc_feature    10221..10234
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            complement(10651..11205)
                     /locus_tag="K6K39_RS39990"
                     /old_locus_tag="EASAB2608_08194"
     CDS             complement(10651..11205)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS39990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_08194"
                     /product="hypothetical protein"
                     /protein_id="WP_221335513.1"
                     /transl_table=11
                     /translation="MSVLFGLVALVGLLCVRDLVLCVGAMQRLLEQAEQPARSGRDPAS
                     CLARGGRVHPFRTVTTEGVPLDREQLLDDTAVAFFLPGCTRCRERLPGFLEYARGLPGG
                     RRQALAVVVGAEEAAAAYAARLAPVARVVVEERGGPVSRAFAVIRFPSVLRVARDTSGA
                     LVATADDPAPGHAGAPASRAA"
     misc_feature    complement(11294..11307)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.07"
                     /tool="antismash"
     misc_feature    11540..11553
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.61"
                     /tool="antismash"
ORIGIN
        1 ctctgcgccg gggtcaggcg gtcgagcacc cgcagcagca ggccgggatt gccctgcgcc
       61 gcggccgaga tctcgtcgcg cacccggggg tcgagcgcgt cctgcgcggc ctcctccagc
      121 agggcggcgg cgtccggcgc aggcagcggg gccaggcgca gcagcggcag accggcgaac
      181 tcgggatcca cgggccggtg cccggcgacg gtgagcagga gcgcgacccg gcccccgtcg
      241 gcgaggcggg cggcgagccg gcccagcgcg gcccgggagg cggcgtccca caggtgggcg
      301 tcgtcgacgc acaggaggac ggtcccggac gcggccgtgc cctccagcgc ggcgacgagg
      361 tcccgcaccg ggccggcggc gcggaccgcg gggaccccgg ccgcgtcgca cagcgcgcgg
      421 agtccgtccg acggctgccg gcagctcccg ggacgggcgc gtacggtcac gacgggtccg
      481 gcggtgaacg cgtcggcggc gaaggcgagg aaggccgacc ggccgcctcc gggctcgccg
      541 gtcacgacac aggccccacc cccgcgcagc cggtcccaca gcgcggccac cacccgcacc
      601 tgggaacccg gccggtaccg cggcgcggcg ggtcccagag tcgtcagtcc ggtcattcct
      661 gtgaccttac tgacgcgtaa ggaagcgcgg aagccttacg tccgggtagg ccgtccaggc
      721 cgtcgcggcc gtcacctgcg ggttcccggg aatccggcgg agcacggcct gtgccgcggc
      781 acaacgcacg cgcccccgcc cggtgcaccc gcacaacgcc ggcggcgacc accgccacgg
      841 gtggtcgccg ccggatcacg ggccgccggt cggcgcgggt gcgacagccg gtcaggaggt
      901 gtgcgggcag ttgccccggt actcctcgat ggtcaggctc ggccgcggca gcgggcacag
      961 gaactgctcg tagcgggtgt cgttgtcgat gaaccgcttc agccacgaga tgctgtactt
     1021 cgcgatcgtc gtgttggagg tgttcggcgt gaagtgggtg gcgccgttca actccaggta
     1081 cgcgcggtcg agggagctgg ggagagcgct gtagaagggc tcggcgtggg tggcgacggg
     1141 ggcgatcgtg tcaccgtcgg cgccgacgat cagcgtgggc gtctggatct cgggccaggt
     1201 cttgtcgagg ttccacgggg tcagcgggat cgccgcctgc agcgaaggcc gcgtcttcgc
     1261 cgcctccagg ctgccgccgc cgcccatcga gtggcccatg acaccgagcc gggtggcgtc
     1321 gacacggccg cggaccgagc tgctgcgggt gaggtagtcg agggcggcga gcaactggtc
     1381 tccccgggag tccggttggt ccagcgtggt gagcgtgtcg atggtgaaga ccacgaaccc
     1441 gtgggacgcc agccgcgggc cgagccagga gatcgaggac tgggtgccgg tgtagccggg
     1501 cgagacggcc accgcgccga aggtgccgtc ggcggtgctg gtcgggtagt agatggtgcc
     1561 gccgccgaag ccggtgacgg cgagccggga gacggacgtc tccgagacgg cgtacgggcc
     1621 gcggagcgcc tcgatgctcg attcggtcgg cgccggaccg cgctcgtagg ggttgtccgc
     1681 accgtgggcc gccggcccgc cgagcatggt caggccgacg acggccgtga ccgcggcggc
     1741 gagggcggcg agccgtccgg aaccccggag ggtgccgcga ccggttggcc ggtcggggcg
     1801 ggccgggtgc ggacggtggg ccggtgccgt ggtgctggtg cgcgggtgct gcacgacgag
     1861 tcgtcctctc tgtcgtctgt cgtggcgagc cgcccgttcg gagccgacgg cgcgcacagg
     1921 cgcgcgacgg ccgaaggacg ccgccgatgg gctggcggtg ccactgtcgg tgccgtgcgg
     1981 gcgggacggg accggcaatg tcaccggtct cgtgcggacg cgcaccgccg cgtcgcggag
     2041 cgaaggcggg gcgaagtggc gtatgactgg gtggacttgc ccaacgcggt ggccagggag
     2101 gccggatgac gggtcgtacg gaatcgatcg aatcgatgga gcagctcgcc gtggtctggc
     2161 gggccatggt gctcgaccgg gatgccgagg ccgacgtgcg ggacctgccg ggcatcgccg
     2221 tccgctgggc cgactgccgg ttcgccttct ggaactgcgt cacgctgacc gaggtcgacg
     2281 cggacgccgc gctggtcgcc cggcgcctca gccaggcggc ggagatcatg cgcgcgaaga
     2341 agcacccggg gttcctgtgg ctcttcgagg acctgctcgg cgacgaggcg cgcggggcgg
     2401 tgcggacggc ggccgagcgg gcgggcctcg cgtacgcctt ccccggcacc ggcatggccg
     2461 gcgacctcct gcccctcccc gaaccggccc accccgagct gacgttcgtc cgggtgacca
     2521 cggaggagca gctggaggcg tacgcggacc tgaactcacg cgcctacggc ttcccgctgg
     2581 aggacggccg cgacgggctg ctcgggtccg cgctgtggaa gaaccaggtg tacgcctacc
     2641 tggggctgcg ggacggcgtc ccggtgacgt gcgccgcgac ggtggaggcg gacggccggc
     2701 tgttcgtcgt gctcgtcgcc acggaccccg cgtggcagcg caggggctac ggggaagcgg
     2761 tgacccggaa ggccctgtac gagggcgccc gggccaccgg cctgacccgc gccacgctgc
     2821 acgcgacggc ggcgggggcg cccgtgtatc cccgcatcgg cttcaagccg aactcgccgg
     2881 tgcgtttcta cagcctgaag gagtgaaccg cccgccaccg gcccgacggt gtgccggcgc
     2941 acgccgtcgg gccggtaccg gtgcgatgga tcaccaggga aggggccggc cgtcgcggta
     3001 gaagccgccg gtggggccgt cgtcggggag ttccgcggcc cacaccacac cggcggcgcc
     3061 ctcccggacg ggccggccgc cggggccgcc catgtcggtg gcgacccagc cgggacagac
     3121 ggcgttcacc aggatccggt cgccgcggag ttcgtcggcg agcatccggg tgagcgcgtt
     3181 caggcccgtc ttggtgacgg tgtaggcggg ggtgccgcct cccatgccgg ccagcgaggc
     3241 cgcttcgctg ctgacgttga cgattctgcc gtggccgctg cgccgcagca gggggaggaa
     3301 ggcctgcacg gtgcgccagg ggccgtggag gttggtctcg gcggcctccg cgacgacacc
     3361 gaggtcggcg gtcgcggcgc gctgccatgt gtcgtaggtg atcgccgcgt tgttgacgag
     3421 tacgtccagc cgcccggacc gctcggccac gtcccgtgcg gcggccgtga cgctgtccgg
     3481 gtcgcggacg tccagccgca gcgggtggac gagggagccg tcccggccca gctgctccgc
     3541 cgcctcctcc gcgtgcgcca gggagcgtgc ggtgaggacc acggtgtgcc cgtgggcggc
     3601 cagcaggcgg cagacctcgt gtccgatgcc ccggttggcg ccggtgacga gggagaccgt
     3661 ggggccgggc tcggccgtgg gacgggtcat ggtggggctc ctgcctgcgg aaggggtcgt
     3721 gtgccgatcc tcggccggag ggaggggagt tgtccaagac gttccgtcag ggggatgcgt
     3781 gacggggtgc gcacccgtgt gctcccaggc ggtgcgtacg ggccagggtc agccggatgg
     3841 cgtaacgagg aaatgattcg gcgggtgaaa ggggcggacg gggcgtggtt ccggccgcgg
     3901 tgagcactga tcatgggcgc gtgcccggcc gggcggcccc gccgcagccg ccggcacggt
     3961 tctcctttcc ccgccttcct ctgagaggtc cgtcatgcct gtccgtcgtc tgctgaccgc
     4021 tgccctcggt tccctcgccc tcaccctggg tctgctcggc gccggcaccg ccaccgcgac
     4081 cccggcggcc gccgatccgt gcggcttcta cgagaccggc tccgacgcct actacaacca
     4141 ctgcacctcc gacggctccc acgtcgtgat caaggtcgag gtggccctgg cgcccgacta
     4201 cgagcggtgc gtggccccgg gccggacctg gctgggttcc gccggcaaga tccagggcgc
     4261 ctactacgtg ggccgcacct gctgatccgt cggcggctgc gccgggtcag atggtcatcg
     4321 gctcctggag ccagcggctg atccggtacg gcagccacca cgcgagcggg ccggcctcca
     4381 gcacgagctt ctctccgcgg aagtcgtcga gcacggcggc cggcaccgag tccgccggcg
     4441 ctccgtaggc cagacgctcg atcgcccgct cgtagtgcgg ctcgtcggcg gtgaagcggc
     4501 gcagttcccc ccagcggcgg tcccgtatct gcacgaagcc cgggcccttg cgccacaggc
     4561 acttgcacag atagtggccc tgccgccagg cgcgcagtgc ctcggcggcc tcggcgggcc
     4621 cctcgatacg ccggggcggc tgcaggtggc tgaggacctg ccaggtgccg tccggcgtcg
     4681 ggggcagccg caggtcccac tcgaccagga cggcccgcgc ggtcaggtcc cgcaccaggc
     4741 tcagcgcgcc caccgccgcg gcggcccgtt cgtcgtcccc ttcggaagcg aggtccacgg
     4801 tcgcgggcag ccgtacgcgc cgggcgccca gccgccagag ccgctcgctc tccccctcca
     4861 gcgggccggg aagggcgagt tcgcccagga acatgccggg gagtgcgcag gcggcggggt
     4921 cgtagtcgcg ccaggcgagg acggcgggcg gactcgtggt gctcgacgtg ctcatgggcg
     4981 tactcctcct cggggcgcgg tcacgcgtgg acgggctcgg cccgcgtcgc gtaggtgtgg
     5041 cgcatgaagt ccagccgcag cagatcctcg ttgacggcgg ccggggcgat gtgcacgtac
     5101 tgcccgccgt cggtgaagac gatcccgagg cggagccagt ggtcgaggag gcgctgcgca
     5161 cccgcctcgt cccgggtcgc tccgggcgcg tcgcgcgcgg ccttgcgggt gagggcggcg
     5221 acggtgtgcg gctggtcgag gaggcggaac gcggccagct cgaaggggtc ggccagctcg
     5281 gtcgtccgcc agtcgaaggc gcggcgccgg gagaccagga cgatccggtc gcccaggtcg
     5341 gtgtgggtca ggcgggcgtc ggcgtggtgc ttcttccacg cggccagggc gtcgttcagc
     5401 gcggtgacgg tcggttcgcc gatgccccgc tccggtgcct cgaagacgta cgcgaggtcg
     5461 tacagctcct cctcgggcag gtcgtaggtg aagcggtagt gctcctcggg ccgcaggccc
     5521 gtgaagccga gttcgggccg ctcgaagtag gggctgaagc gttcgatggc gatccgggcc
     5581 gacaggtcga ccggcgggtc gagatgttcc agcgccggta tctgggcgat caccggctcg
     5641 tagtcccggt cggtctcccc ggggaagccg tgcaggtagt tccaggcgac cgacagaccg
     5701 gcctcggcgc cgtcacggag catccggacg ttctggcagc cgctgacgcc cttgtccatc
     5761 aggtccagga cccggtggtt gagcgactcg atgccgggct ggacgtagat catccccgcg
     5821 tcggcgaggg tacggagctg ggggcggcgc atgttggcct tgatctcgat gtgcagccgc
     5881 aggtcgtacc cgctgtcgat gatcctgggc agcacggtcg tcaggtagcc catgtcgagg
     5941 atgttgtcca cgacgtacat gtccaggacc cggtggcggc gggccagttc gacgatctcc
     6001 tcgtagaagg tgtccgggct cttggaacgg aactgcatga acgatccgtt gagcccgcag
     6061 aaggtgcagt ggtgcttctc cccccaccag cagccgcggg cgccctccac gaccagcttg
     6121 ggctcgaccc agtgacgggc ggcggaggcg gcgaggcgct cgaagtagcc gctgtagtcg
     6181 ggcggcagga tcgcggcggg cggcagcgga cgggtggcca tcgggttggc acggctcgcg
     6241 ccgtcggctg cccggtggca cagtccgggc accccggcga ggtccgagcc gtcggcgagc
     6301 gcggtgagca gctgcgggaa ggccgcctcc ccctcgccgc gtacgacgtg gtcgacgaac
     6361 gggaagttgc ggtggacggc ggcgccctgc gcgccgtcgc agttggcccc gcccagcacg
     6421 gtgacgatgt gcggggcgag ctgcttgacc cgccgggcgg cggccagcgc cgcggtgttc
     6481 tgctggaagg tggaggtgaa cccgacgaca tcgggtgcct gcgcgacgat ccgccgcgcg
     6541 atctcgtcca cgaactccgg caccacccgg tgcagtgccc gggtcatggc catccgcggc
     6601 ttcttcagct tcccgcgcat caccgcggtg aactcctcct cgcgccagtg cggatcgtcg
     6661 tacagggcgg aggagaacac ccagtcgccg cagcccatga agtaggacga cagggcgtag
     6721 tactcgtagt cgtcgccggt gaacggggtg cgcgcggtga tccagtcggt gaattcgagg
     6781 ttggcgtgca ggacctcggc ctcggcgccg ggcacgcgct cgtccacgct gcgtttgagg
     6841 atccccagcg cgagggacgg gaggtcgatg ggcgaccagg gcatgttgac cagcaggaca
     6901 cgcatgtcgg ctcctcgggg aggggggacc ggccggcccg gcggcgcacc gccgggccgg
     6961 ccggcggggg tcagtcctct tccgcgtcct cggcgttgcg gaacgggacg gtgacggtga
     7021 tgccgacgct cggcttgcgg ttctcctcgt cacccgcgag cgggtcgttg tggatgatgt
     7081 ccttctgcac gggaccttct cctctccgtg aggtgttcgg cggtgtggtg ctccccgctc
     7141 cgggcggagc ggggcgtctg gggccggtgg tgcgccgggc cgcgcagttc ccggtcgagg
     7201 aagaccacgc cccggcgcag cacggtgacg tggtcgccgc cgtcgtagcc gtcgtggccg
     7261 gagtccagcc acagcgccgc gtgccgcacc ccggcggcgc gcagcgcggc gaggtaggcg
     7321 cggatctgac cgggcgggca cttggcgtca tggatggcgg ccgccacgag cagcggggcg
     7381 cggaccgcgg cggcgtagtg gatcggtgag ctgcgcgcat accgttcggg cacctcgtcg
     7441 ggggtgccgc cgaacagccg ctcgtccagg gcgcgcaggg cgggagtggt ggtgcggtac
     7501 gcggccgcgc agtcggcgac cggcttcacc gcgacccccg cctgccacag gccggggcgg
     7561 gtgccgaggg cgagcagcac gaggtagccg ccccaggagg tgccccacag ccccacggcg
     7621 tccgcgcgga tcagccggcg ggcgacgagg tcggcgcgga cggacgccag gtccgcgacc
     7681 tgggtgagtc cgacgccgtc ccggaaggcc cgccgccagc gcggcccgta gccggtggag
     7741 ccgcggtagt tgacgcggac gaccgcgaaa ccggacgcga cgagggagtg gacgacgccg
     7801 tcgtaggcgt cccggtcgtg gtcggcgggc ccgccgtgca ccaggaacac cgccgggacc
     7861 ggaccgcgcg gcgcgtcggg caggctgagc aggctgtgca cggggccgtc cgggccgggc
     7921 gtccacacgt cccggtgggt accggggaac ggctcgggca gggcgggcag ttcgggcagg
     7981 gcggtgcccc gggtggagta caggcggggc ggacggccgg cggccgtcca gaggtagtgc
     8041 aggtcgcccc cgggccgggt ggcggcgtcc agcacggtgc ccgggggagt ggggacgggg
     8101 gagagggtgc gcgcggtgag gtcggcgcgg tgcagcgtcg agcggccgtg gcggtcctgc
     8161 cgtaccagga cggaccggcc gtccgggtcc cagcgggcgg tgatctccgt gtcgaaggcg
     8221 caccagtcgt gcgtggcggg accgctgccg ggccgccagg acgccaggac gtagccgtcc
     8281 tcccgctcgc ggatcagcag gagttcctcg cggtcggggc cgggggcgaa gcccagggac
     8341 cacagccggc cggtgtcgcc gccgggcagg acggcccgta cgacaccgtc gcaggtgagc
     8401 acggtgaccg cgtcggcgcc ggcgagcgcc agcagccggc ccccgggggt gatgccggtg
     8461 agggtgacat ggcccgggag gcgggccacc gtgcgggccc ggccgccgcg cgggcccacg
     8521 tggacggtgg tggcgcggcc gtccccggcc gcgacggcga cggtgccgtg gtcgctcacc
     8581 gcgaggcccc gggggagccc gggcgggacg tcggtcagac cgggccggtc gggaccgccg
     8641 gtgaagggct ggaaccgcca gcagcccgcc ccgtgcgcgt cctcgtcgaa ccaccacacg
     8701 tgcgcgtccc ggtcgacggc gccgtgcagg gtgccccggg cgcgccgggt gacctgccgc
     8761 gcgcgaccgg ccgcggcgtc ccaggcgaac acctcgcacc ggccgccggc gtcggcggtg
     8821 aacaccatcc tggccgggtc ggcggcgcac acctccggca acgcggcccg gtacacctgg
     8881 tagccgccgc tcatccggtg acctccgccg ctcttcccgc ggcctccggt gcgagcacgc
     8941 cgcgcaccgg gcgccgggag ctgtgcgccg ccagcagggc cagcagcaca ccgcagacgg
     9001 ccgcgggcgc cgcggcggac acccggtcgg cgagggcgcc ggcgaggacc ggggcgagcg
     9061 cggcggcacc cgtggtcgcg gtggccagca ccgcgccggt acgggcctgc agcgcgggcg
     9121 ccgtgacctg gacggcccgg gcctggagca cgacggaggc gagcggcatc agcaggcaca
     9181 ccaggccgaa cagcagcccg tacgcccacg cgctcgtgac cacggcgagc gcggcggcga
     9241 gcgggacgag cagccaggtc acgccgggga cgacccgtgg cgcgccgaac cgccccgcca
     9301 cgcgcggcgc ggcgagcgcg cccaccagac cggcggcacc cgacagggcg aggaccgcgc
     9361 ccagcacggc gcccgcgtgg ccgtcccgcc ggagggtgaa gacggcgccg tagtacagcg
     9421 ccaccaccac ggcgttgacg gtggcgcccc acaccaggac cagccgcagc agcggagcgg
     9481 aacgcaccag ccgcagcccg gccgcgccct cccgcagcag ccccgccccg cgctgccgcg
     9541 gcgacgccgc cctgaggtcg gcacgcatgg ccgcaacgca cagggcgctg acgaggtagg
     9601 agagggcgtc ggcgaggaac ggcagcgcgc gggcggcctg gtagaggagc ccgcccagcg
     9661 ccgggccggt gatcagcgcg ccctggtcgg cggcggcgag ccgggcgatc gcccggggct
     9721 gttcgggtcc cgggctgacc agtgcgaccg tcccgcgcgc cgccgcctcg aagcaggcgg
     9781 tcgccagccg ctcgaccagt acggcggtga ggatcaggcc cagcggcggg tgcccggcgg
     9841 ccagcgcgag ggccacgcag cccatcgcga gcgccgagac ggccgcggac ccgaccatca
     9901 cgcgtttgcg ggcaccccgg tcggcgggaa gggcgacgag cgggccgagg agcagcccga
     9961 gggcggtgga ggcaccggcg atcagaccga cggtctgggg cgagttgccc agccccagga
    10021 ggagcagcgg gagcacggtc cccgaagcct ggctgccgac cccgtcggcg gcgttggccc
    10081 accacaggag ccggaagtca cgtggttccg cccgctggtg ggacggtcgt gcggtcgacg
    10141 ctggccgttc cacaagcacc tcaccgatgt ggcgaaattg tgcagaaagt gtggcgagag
    10201 cggagcgagc gggagcgtaa tcgagcgcga acaagcgtca caagagcccg aggaggctgg
    10261 ccggatccgt gtggtgcggc ggtgcgacgg ggccggtccg ccgtacgcgc gaagagggac
    10321 tgatccttcc gcaccaacac ggcgggacgc cgcctttccg ccagggaaaa cccgcgacgg
    10381 cgcccatgcc cctgcccggg tgggccggac gggcgggccg gaacgggagg ccggccgtcc
    10441 ggggcacggc ggcaccggcg gcgcgccgct ttcggccgag aacgtgcgcc gcacccaccc
    10501 gccgcggggc gccccgccgt acgagcaccc ggtccacgcg aggggcgggc cagggcggcc
    10561 gcctggatca tgcgggccgg cagcgcgcgc cgtacggttc cccgcggcgg cgcgcacctt
    10621 ccgcccgggc cgtcgcgtcc gcggacggac tcacgcagcg cgggaggccg gagcaccggc
    10681 gtggccgggg gccgggtcgt cggcggtcgc gacgagcgcg cccgacgtgt cgcgggcgac
    10741 ccggagcacg gacggaaagc ggatgacggc gaaggcccgc gacaccggcc cgccccgctc
    10801 ctcgacgacc acccgtgcca cgggggcgag ccgggcggcg tacgcggcgg ccgcctcctc
    10861 cgcgccgacc acgacggcca gcgcctgccg gcgcccgccc ggaagaccgc gcgcgtactc
    10921 caggaacccc ggcagcctct cccggcacct cgtgcagccg ggcaggaaga aggcgaccgc
    10981 cgtgtcgtcc agcaactgct cccggtccag gggtacgccc tcggtggtga cggtccggaa
    11041 ggggtgcacc cgcccgcccc gggcgaggca ggacgccggg tcccggccgg accgcgccgg
    11101 ttgctccgcc tgctccagga gccgttgcat cgcccccaca cagagcacca gatcccgcac
    11161 gcagagcagg cccacgagcg cgaccagccc gaacaggaca gacatgtcac ctcctcgcgc
    11221 catggcggac ggaacggctc ggcaaggccg tcgaggccgg cgggcgcgcc gccgcccgcc
    11281 ggccgtccgg ccgttggaat actgatgggc gcccgttggg caaaccttgg aagatccttg
    11341 aatgcgcagg ccggtccgct gtggcgacca ccggccgtcg acgcgagggg gaagaggatg
    11401 tccgtggatt tcgttctgct cggcggcatc gaggcacgcg tggacggggt tccggtcgac
    11461 ctgggccatg tccgccagcg ctcggtgctc gcgggcctgc tggtcgacgc gaacgccccg
    11521 gtgccgaccg ccaggctcgt ggaccgggtc tgggggggcc ggcccccgca gcgcgcgcac
    11581 gccacgctct acagctatgt gtcccgcctg cgcggcgccc tggccgcggc gacgcaggac
    11641 gtacgcatca cccggcgcac gggggcctac gtcctcaccg tcgatccgtc cgccgtggac
    11701 gtgcaccgct tccgcgacct ggtcgcgcgg gcccgcaccg ccggcgagga ccgcgccgcg
    11761 acgctgttcg cgcaggcgct cgccctgtgg cgtggcgacg ctttcggcga cctggacgtc
    11821 ccctggttca acgccctgcg cgcgtcctgg caccgggagc ggcacgcggc cgaactcgac
    11881 ctcaccgacg tccggctgcg gctcg
//
