LOCUS       NZ_AP024135            20711 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8789756
            Orig. end                         :: 8810467
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20711
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="37"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20711
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20711
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10711](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10711
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            complement(50..1291)
                     /locus_tag="K6K39_RS38495"
                     /old_locus_tag="EASAB2608_07880"
     CDS             complement(50..1291)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984097.1"
                     /locus_tag="K6K39_RS38495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07880"
                     /product="serine hydrolase"
                     /protein_id="WP_221335447.1"
                     /transl_table=11
                     /translation="MSPTSVRLRRVAMVALLTGTLVAPCTAGAAPASVPSAPAAGTPRP
                     SPSGPDVRPLSPDVTRQLDASVRRVMREAKVPGVTVGIWTPGQRGYVRSFGVADKETGR
                     RMTPDLYTRIGSETKTFTVTALLQLVDRGKVRLDDPIGRYVEGVPNGDRITLRQLAGMR
                     SGLFNYSEDDDFFAALTSDPQRSFTPRQLLDYAFRHPVLFQPGQKFSYCNTNLILLGLV
                     VEKESGQRLGDYLKQHILDPAGMKDTLLPKGSAFPTPHAQGYTDQTANGEVAETAGWNP
                     SWGWAAGAMVSTLEDLRIWAPTVATGELPDGRRMISPATQRQRLVTPATPIPGAGYGLG
                     IFDVQGWIGHNGSLPGYESLTIYLPATRTTLVVLLNTDIDHDDEEPSTLFGQAITEIIS
                     PRHVFDLPAAPAAR"
     gene            complement(1745..2212)
                     /locus_tag="K6K39_RS38500"
                     /old_locus_tag="EASAB2608_07881"
     CDS             complement(1745..2212)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670666.1"
                     /locus_tag="K6K39_RS38500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07881"
                     /product="hypothetical protein"
                     /protein_id="WP_059247312.1"
                     /transl_table=11
                     /translation="MTNTMWMRGVEWLAAASADPRACKWEWDHGEGIALLEAGRFWDVL
                     SVPDRLGLLTLDLLWRPGLPVPGPTLVDTAAGRVGFFVPPDPSGGWVGAGLRYATKGSW
                     VAAPPPYRPARSLEWLVPPDGTGTLHAPGTLEEALQQANGTLAVLAPLCGR"
     misc_feature    complement(2311..2324)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.73"
                     /tool="antismash"
     misc_feature    2490..2508
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            2554..3903
                     /locus_tag="K6K39_RS38505"
                     /old_locus_tag="EASAB2608_07882"
     CDS             2554..3903
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (54-363). E-value: 5.2e-46.
                     Score: 149.1. Matches aSDomain:
                     nrpspksdomains_K6K39_RS38505_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892351.1"
                     /locus_tag="K6K39_RS38505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07882"
                     /product="transaminase"
                     /protein_id="WP_221335448.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.1e-45, bitscore:
                     153.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRTRLHALLARESAEAARRNPRSRAAYARADHLFGRVPMTWMNK
                     TAGAFPRYLAAARGARVTDVDGHQYIDFCLGDTGAMAGHSPAPVTEAVHRRYAELGGAT
                     AMLPTEDAEWVGAELTRRFGLARWSFSLTATDANRWAIRLARAVTGRPKILVNSYCYHG
                     SVDESLIVTAPDGTGTPRPGNVGAPCDVTLTSRVAEFNDLAGLERELAHGDVAAVLMEP
                     ALTNIGIVLPEPGYLAGVRELTRRHGALLINDETHTFSAGPGGCTAAWELEPDLLTIGK
                     AIGGGIPAGAYGLSAELAERLLARTDLDLVDMGGVGGTLAGNALSVAATRATLAHVLTD
                     EAFARMSALAERFEAGVRAGLDAHGLPWSVSRLGARTEYRFTSPAPRTGTESAAAADPE
                     LEDFLHLYLANRGILLTPFHNMALMCPDTTENDVDTHTEVFAAALAELAG"
     aSDomain        2716..3642
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS38505_Aminotran_3.1"
                     /evalue="5.20E-46"
                     /label="K6K39_RS38505_Aminotran_3.1"
                     /locus_tag="K6K39_RS38505"
                     /protein_end="363"
                     /protein_start="54"
                     /score="149.1"
                     /tool="antismash"
                     /translation="AAARGARVTDVDGHQYIDFCLGDTGAMAGHSPAPVTEAVHRRYAE
                     LGGATAMLPTEDAEWVGAELTRRFGLARWSFSLTATDANRWAIRLARAVTGRPKILVNS
                     YCYHGSVDESLIVTAPDGTGTPRPGNVGAPCDVTLTSRVAEFNDLAGLERELAHGDVAA
                     VLMEPALTNIGIVLPEPGYLAGVRELTRRHGALLINDETHTFSAGPGGCTAAWELEPDL
                     LTIGKAIGGGIPAGAYGLSAELAERLLARTDLDLVDMGGVGGTLAGNALSVAATRATLA
                     HVLTDEAFARMSALAERFEAGVRAGLDA"
     gene            3942..4382
                     /locus_tag="K6K39_RS38510"
                     /old_locus_tag="EASAB2608_07883"
     CDS             3942..4382
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559938.1"
                     /locus_tag="K6K39_RS38510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07883"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_059254739.1"
                     /transl_table=11
                     /translation="MDDIDRAILRELQTDGRIAYADLGPKVGLSASAARQRLQRLLDSK
                     AVQVVGVTDPMAMGGQAMALLGIGVDGDPRTVADALAERPEVVYSVLTSGGFDLFAEVV
                     APGPKALLDFVNDVVRPLDGVREIRSFPYFGIHTHRFLWDVG"
     gene            complement(4402..5506)
                     /locus_tag="K6K39_RS38515"
                     /pseudo=""
     CDS             complement(4402..5506)
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670663.1"
                     /locus_tag="K6K39_RS38515"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGSVRGWSPRGHREDRGWLRGAPPPWWVRVLPVLLLVAVGSATLA
                     TPHARDLGFLLGAIPPLAVLSYGPLATGLLGVGVVVVLNVPATHLNRPGDTDLLTIVFV
                     AALSVFVSFVRSHRDAQLDTERTIGEAVQRRAAAAAGAGRPGRLRGLLPGRAGRDAGGR
                     GLLRRAAGAVRRARGHGGRAGARAVGGGDGGVAAGGVPGGGPGPAGPGVGGGPAGPPAG
                     GGLGGRTARRAVRDRPAAGVRRRLGRGPGGGLRSSATGAAARGGGPRGRRRAGSAAGHR
                     AARRRPAEGGHRAARPGRPAVPGLRRGVGGAGRRRHLLSAAGAAGRPGRHPVRRAARRG
                     LGGPAPAALRGPRRRHRPGAGTRAAGRL"
     gene            5730..6638
                     /locus_tag="K6K39_RS38520"
                     /old_locus_tag="EASAB2608_07886"
     CDS             5730..6638
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670662.1"
                     /locus_tag="K6K39_RS38520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07886"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_094374928.1"
                     /transl_table=11
                     /translation="MTDLVVRTLDESSAQLFRTMPDPLALGERHRYTRYRPDWQRVAVR
                     DGRTVARAAWWAGPEDPEPRLINWFDVAEGEEEAGAELLRTAPWGTAELELDLPAGWRD
                     DPRLRAAADARAAAARRAGYTPLVERFLYRWTPDRGLPERPGRLVFTPEPDDAVFYELL
                     RRVSTATLDAHARRAIAEGGVDQAAQEDLDFFRWLPSPRDWWQLALTPAGEPVGIHIPA
                     RNPSGPCVGFIGVVPEHRGHGYAYDLLAECTHFLAGQGAEFIAAATDQGNVPMAAHFTT
                     AGYPVVRERVTYWADGGPGAG"
     gene            complement(6732..7619)
                     /locus_tag="K6K39_RS38525"
                     /old_locus_tag="EASAB2608_07887"
     CDS             complement(6732..7619)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070082.1"
                     /locus_tag="K6K39_RS38525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07887"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_059247309.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.7e-21, bitscore:
                     76.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 6.4e-09,
                     bitscore: 34.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGLLGTGPWARAAYAPALAGHTGLEFAGVWGRRPEAATALAEQ
                     YDVAAYADVDALLADVDAVAMALPPSVQAELAVRAARAGRHLLLDKPLAVSVAEGRAVA
                     EAVERAGVASVVFFTARFQKEPEAWIEEQAAVSGWFTARAQWLGAVFTSDSPFAHSPWR
                     REKGALWDVGPHALSVLLPVLGDVRHVVAAAHGPADTVHLVLDHATGASSTLTLSLTAP
                     PAAAGADVELRGEAGVTVLPGSSEGAVPALDRAADALVRAARTGRPHSCDAAFGLRVTE
                     ILAAAEARLAAGTD"
     misc_feature    complement(7623..7634)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(7655..8638)
                     /gene="tgmB"
                     /locus_tag="K6K39_RS38530"
                     /old_locus_tag="EASAB2608_07888"
     CDS             complement(7655..8638)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tgmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670660.1"
                     /locus_tag="K6K39_RS38530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07888"
                     /product="ATP-grasp ribosomal peptide maturase"
                     /protein_id="WP_059247308.1"
                     /transl_table=11
                     /translation="MTVLILTSEEDVTADMVVLRLGEAGVPVVRLDPADLTNGVALSGE
                     YAQGACRGHLSVGGRLVSINGLRSVWVRRPGVPAARAAQPSAWLTEESSQALYGMLRCS
                     DARWMNHPDAARRARHKPWQLHLAQRSGLPVPATLVTTFPQAAREFAERFPDLVVKPVS
                     GAHPQEPPRAVPTSRVAPDTDFTAVAFGPTLLQRRIPKRADIRLTVVGGTLLAARKPAD
                     PDAHPDDVDVRFAPSVSPWLPADVPPRVAEGVLRYMTGAELAYGAFDFAEDSDGIWWFL
                     ECNQSGQFGFVEMDTGQPIAATIADWLAGDGDPGRRCAEGDRSAAS"
     misc_feature    8601..8616
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.33"
                     /tool="antismash"
     gene            complement(8655..8846)
                     /gene="tgmA"
                     /locus_tag="K6K39_RS38535"
                     /old_locus_tag="EASAB2608_07889"
     CDS             complement(8655..8846)
                     /codon_start=1
                     /gene="tgmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386718.1"
                     /locus_tag="K6K39_RS38535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07889"
                     /product="putative ATP-grasp-modified RiPP"
                     /protein_id="WP_014670659.1"
                     /transl_table=11
                     /translation="MQPFTLNYARPAVQLDVTAPYAYDSGLQLNVLPDGRIAATDHATL
                     RALGTTTSTAGSKTHFDD"
     misc_feature    complement(8906..8919)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            complement(8947..9783)
                     /locus_tag="K6K39_RS38540"
                     /old_locus_tag="EASAB2608_07890"
     CDS             complement(8947..9783)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546000.1"
                     /locus_tag="K6K39_RS38540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07890"
                     /product="fructosamine kinase family protein"
                     /protein_id="WP_059247307.1"
                     /sec_met_domain="APH (E-value: 8.9e-16, bitscore: 57.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAARLTGRPVSGARPGSGSPAEVLLDGGTPVMVKRGDGPGAVRAE
                     VAGLRWLAAAEAVRVPAVLGHDERWMVTERVPTGSPDPEAALRFGQALAALHRAGAPHF
                     GAPPPGGPEDAYIGRAPLRNAPGGDWPRWYAEHRVLPYVRGAVDRGTLRPGEAAVFERV
                     CARLPDLAGPAEPPARLHGDLWNGNVLWGADGEVRLIDPAAHGGHRETDLAMLQLFGCP
                     HLDRVLAGYRQAAPLADGWRDRVGLHQLFPLLVHAVLFGRGYAEQALAAARGALAG"
     misc_feature    9875..9888
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.86"
                     /tool="antismash"
     misc_feature    9875..9889
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.36"
                     /tool="antismash"
     gene            10001..10711
                     /locus_tag="K6K39_RS38545"
                     /old_locus_tag="EASAB2608_07891"
     CDS             10001..10711
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="K6K39_RS38545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07891"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_260336028.1"
                     /sec_met_domain="CDPS (E-value: 5.7e-88, bitscore: 293.1,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTASVLMADVFEVQPYTSHCEVILGEGAHAVIGVSPGNSYFSAR
                     RLHDLARWGLDHFDRVDFVYTDLYVAEMYEASGYPPDEARRKAVKNLRGVRAKVRDAVT
                     AADPDGTRLDWHPMSEFRTNPAYQEIHRQLKARLVCDGSFRAVCEALVNRFLSARGETP
                     TERQRAVCLEYVCAEAPLFLDTPAILKVPSSLNCYHQLLPMAELLYSRGAGLRASRNQG
                     HAIVTPAAPEGTTA"
     gene            10708..11919
                     /locus_tag="K6K39_RS38550"
                     /old_locus_tag="EASAB2608_07892"
     CDS             10708..11919
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033070.1"
                     /locus_tag="K6K39_RS38550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07892"
                     /product="cytochrome P450"
                     /protein_id="WP_059247306.1"
                     /sec_met_domain="p450 (E-value: 1e-12, bitscore: 46.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPDTRTDHPPLPRFPFSWDGTRVPAEVAALRTATPVRRVRTI
                     AGDEAWLVSSYELCAQVLKDDRFSLKDTSAPGVPRQYALTIPPEVVNNMGNITGAGLRR
                     AVMKALSPRTPGLTEWLRAEAHRLVDLITADGPTADLRGAFCEPYSAGMHCRILGIPQT
                     EAPAFLRSLDIAFMNSPCPVTGARLNWDRDLARMAALLDDPATGGLMGELAALRDDPGH
                     AHLTDAMLATVGVTLFGAGTVSTSGFLTMALVYLLTHPIARDLLRDRPDLIGPGVEELL
                     RVNLSIGDALPRLALDDVRLGDVDIRAGDLVLVLVEGANLDPDTFPDPHRFDVHRDNAA
                     DHLSFGGGAHYCPATALGRAHARIALEVLLDRLPDLALAVPPGQLVWRTGFMKRIPERL
                     PVTW"
     gene            complement(12019..12897)
                     /locus_tag="K6K39_RS38555"
                     /old_locus_tag="EASAB2608_07893"
     CDS             complement(12019..12897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670657.1"
                     /locus_tag="K6K39_RS38555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07893"
                     /product="SCO6745 family protein"
                     /protein_id="WP_059247305.1"
                     /transl_table=11
                     /translation="MADGMARFLWERYEPVHDLVYFAPEAQRAAQRLGMRGFWMGYFAL
                     RAAPLGAVPPSVVTSCFYVFHPTRVARALPDAWTYATPADVVAARQEAVDEAMTRLFGA
                     DTVGSAAFAQTADLAWETAAAADTTGRVLAAANQALERPDRPTARLWQALTTLREHRGD
                     SHVAVLVALGIGPVEAMVLKAAAGETDAALLRESRKWPQEEWAAAEARLRADGRLAEDG
                     SLTPAGAALRTEAEALTDAAAEGPWTALGAERAGRLAALLEPLAHAVHEAGLMPAGNPV
                     GLTRGTYPGGR"
     gene            13202..13771
                     /locus_tag="K6K39_RS38560"
                     /old_locus_tag="EASAB2608_07894"
     CDS             13202..13771
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670655.1"
                     /locus_tag="K6K39_RS38560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07894"
                     /product="hypothetical protein"
                     /protein_id="WP_059247304.1"
                     /transl_table=11
                     /translation="MRSARMLLATAAATAALAFATPGAAFAVPAEHDDGRDDSSYSKEH
                     DSGSDREDKGSDSDHDKNYGNKRDGGGEHDGPRGGMHTGGGALAAVRSDEWGSGDDSRF
                     DPESYRDKGGRDSGEEKSEKGDKGDRGEKGEWGGGGGHDRPRGGMHTGGGGLATPGVTA
                     SGLAVLGVGAAGAYALRRRKAAEPAS"
     gene            13923..14630
                     /locus_tag="K6K39_RS38565"
                     /old_locus_tag="EASAB2608_07895"
     CDS             13923..14630
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388040.1"
                     /locus_tag="K6K39_RS38565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07895"
                     /product="class F sortase"
                     /protein_id="WP_059247303.1"
                     /transl_table=11
                     /translation="MAADPSSPTPAGPAADGRHSGRGGRLTLWGVAAVFLAVSMFGGHE
                     TPDETPAAPRASGAGAVAPADPRQPGEPRQSGEPPRSAEPLPRSAPTRLRIPKISVDAP
                     FTALAIGASGQLQPPPAADTNLVGWYADGTSPGEEGTAIIAGHVDTMTSAAVFAELDRL
                     RPGDRFSVERADGRTAEFVVDSAETFAKDDFPSERVYADASRPEVRLITCAGDYDRTVR
                     DYTDNLVVFAHLE"
     gene            complement(14647..15813)
                     /locus_tag="K6K39_RS38570"
                     /old_locus_tag="EASAB2608_07896"
     CDS             complement(14647..15813)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670653.1"
                     /locus_tag="K6K39_RS38570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07896"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_059247302.1"
                     /transl_table=11
                     /translation="MHTIPLTAGLIRGALELERTAHGLLPHRLPARARARCADPQLALA
                     ESQPSGVRLAFRTRATTVELDALPTKRVYPGVPPRPDGVYELLVDGRPAGSASLAEGDT
                     LTIDLGTGTAEHRPGPVGTVRFTGLPDADKDVEIWLPHNERTELVALRADAPVEPVPDR
                     GRRVWLHHGSSISHGSDAASPTTTWPALAASLGGVELINLGLAGSALLDPFTARALRDT
                     PADLISVKLGINVVNTDVMRLRAFGPAVHGFLDTVREGHPDTPLLVVSPVLCPMHEETP
                     GPTAMDLAALGEGRMRYRATGDPAERAAGKLTLEAVREELARIVRERAAEDPRLYHLDG
                     RELYGEADFAELPLPDGLHPDTAGHRRIGERFAALAFAADGPFAGRAA"
     gene            complement(15840..16412)
                     /locus_tag="K6K39_RS38575"
                     /old_locus_tag="EASAB2608_07897"
     CDS             complement(15840..16412)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951238.1"
                     /locus_tag="K6K39_RS38575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07897"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_059247301.1"
                     /transl_table=11
                     /translation="MARAGLTTERLVRAGAELADEVGFDQVTVSALARRFDVKVASLYS
                     HLRNSQDLKTRIALLALEELADRAAEALAGRSGKDALGAFAHVYRDYARAHPGRYAAAR
                     HPLDSATAAGSAGVRIAQLTRAVLRGYDLTEPDQTHAVRLLGSVFHGYVSLETAGGFSH
                     SAPDSEESWARILDALDSLLRTWPAHP"
     misc_feature    16802..16822
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.97"
                     /tool="antismash"
     gene            17009..17758
                     /locus_tag="K6K39_RS38580"
                     /old_locus_tag="EASAB2608_07898"
     CDS             17009..17758
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-167). E-value: 1.6e-09. Score:
                     29.8. Matches aSDomain:
                     nrpspksdomains_K6K39_RS38580_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008411687.1"
                     /locus_tag="K6K39_RS38580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07898"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_059247300.1"
                     /transl_table=11
                     /translation="MAEHTLKDKVAVIGGGEKNLGGLLSRTFAEAGAKVVVHYHTSEKE
                     AEETVQAIRDAGGQAVSAQGDLTDVAAVRQLFDTAVDTYGGVDVAVNTTGMVLRKPILE
                     TTEDEYDRMFGINAKAAYFFIQEAGRRLNDHGKIISLGTSLLAAFTDGYSTYAGGKAPL
                     EHFTRAAAKEFADRSISVNVVAPGPMDTPFFYGQETPERVEFHKSQAMGGQLTHIEDIV
                     PLIRFLATEGWWITGQTLFANGGYTTR"
     aSDomain        17036..17509
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS38580_PKS_KR.1"
                     /evalue="1.60E-09"
                     /label="K6K39_RS38580_PKS_KR.1"
                     /locus_tag="K6K39_RS38580"
                     /protein_end="167"
                     /protein_start="9"
                     /score="29.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVIGGGEKNLGGLLSRTFAEAGAKVVVHYHTSEKEAEETVQAIR
                     DAGGQAVSAQGDLTDVAAVRQLFDTAVDTYGGVDVAVNTTGMVLRKPILETTEDEYDRM
                     FGINAKAAYFFIQEAGRRLNDHGKIISLGTSLLAAFTDGYSTYAGGKAPLEHFT"
     gene            17845..18159
                     /locus_tag="K6K39_RS38585"
                     /old_locus_tag="EASAB2608_07899"
     CDS             17845..18159
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508344.1"
                     /locus_tag="K6K39_RS38585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07899"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_059247299.1"
                     /transl_table=11
                     /translation="MTAELTDPAIAGFVAAVNAGDKEAFFAALTDDATMSDDGTDRDLR
                     EWTEREIFSSNGRMDVEEVSTDGRTLTATYTNSTWGSMRTRWVFTVTGGRISRFETGRA
                     "
     misc_feature    18178..18193
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.26"
                     /tool="antismash"
     gene            18309..>18392
                     /locus_tag="K6K39_RS42120"
                     /pseudo=""
     CDS             18309..>18392
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018479.5"
                     /locus_tag="K6K39_RS42120"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRGRDPGEEHRASTPLELLFDLTFVVAV"
     misc_feature    complement(18356..18369)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            18503..18625
                     /locus_tag="K6K39_RS41520"
                     /old_locus_tag="EASAB2608_07901"
     CDS             18503..18625
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS41520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_07901"
                     /product="hypothetical protein"
                     /protein_id="WP_260336029.1"
                     /transl_table=11
                     /translation="MFALALAASTLGVGGAVLGMGPAVAAALAANLAVYRHRRR"
     gene            18633..19508
                     /locus_tag="K6K39_RS38590"
                     /old_locus_tag="EASAB2608_07902"
     CDS             18633..19508
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008411691.1"
                     /locus_tag="K6K39_RS38590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07902"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_059247298.1"
                     /transl_table=11
                     /translation="MGLDLNKLEHLIAVAEEGSITRAAARLHLSQQALSTSIRVLEREV
                     GVPLLERATTGISLLPAGTALVEDARVLRGTARSALQRARRIGRGEKEVLRLGHTPAVT
                     GEEVIALLRQVTAAHPHLATDVNQRYPDELTAALLAGDLDIGLCRAMPPPHGLARTTLG
                     HQPLNIAVAADHPFSTRPSVALAELADQHFVVWGQPGHSGYTDLLISHCRAAGFEPRTE
                     RTPLQGTPPATAVIGTDRLAFVTTPPGPAAGGAVRVLALDPPLYAPLHALYSPRTTSPA
                     KDTFLATATL"
     gene            complement(20243..20671)
                     /locus_tag="K6K39_RS38595"
                     /old_locus_tag="EASAB2608_07904"
     CDS             complement(20243..20671)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022355.5"
                     /locus_tag="K6K39_RS38595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07904"
                     /product="DUF2690 domain-containing protein"
                     /protein_id="WP_059247297.1"
                     /transl_table=11
                     /translation="MKLLCGNVARATVLVAATLFSTLGAAGAAQAEPSVQAAAGTCYHK
                     SDAYTARTATVDTIKIELRYSPSLRCSWGRITNADPGDKVWVDRSYDGGRTWEGPLNVT
                     TVQTGSDTFTDARYNGGNLMRACGKNDSTGNVRCTSWW"
ORIGIN
        1 cgcaccccgt gcgggtgcaa ggaggcggaa aaccggccga atcggcaccc tatctggccg
       61 ccggtgcggc cggcaggtcg aacacgtgcc gcggggagat gatctcggtg atcgcctggc
      121 cgaagagcgt gctgggttcc tcgtcgtcgt ggtcgatgtc ggtgttgagg agcaccacga
      181 gggtcgtgcg cgtcgccggg aggtagatgg tcagcgactc gtagccgggc agggagccgt
      241 tgtggccgat ccacccctgc acgtcgaaga tgcccagccc gtacccggcg ccggggatcg
      301 gtgtggccgg ggtgacgagg cgttgccgct gtgtggcggg gctgatcatc cgccggccgt
      361 cgggcagttc accggtcgcg accgtgggcg cccagatgcg cagatcctcc agggtggaga
      421 ccatcgctcc ggccgcccag ccccaggacg ggttccagcc ggcggtctcg gcgacctcgc
      481 cgttcgccgt ctggtcggtg tagccctgtg cgtgcggggt ggggaacgcg ctgcccttcg
      541 gcaggagtgt gtccttcatg ccggccgggt cgaggatgtg ctgcttcagg tagtccccga
      601 gccgctgacc gctctccttc tcgacgacca ggccgagcag gatcaggttg gtgttgcagt
      661 aggagaactt ctgaccgggc tggaacagca ccggatgtct gaaggcgtag tcgagcaact
      721 gccgcggcgt gaaggagcgc tgcgggtcgg acgtgagtgc cgcgaagaag tcgtcgtcct
      781 cggagtagtt gaacaggccg ctgcgcatgc cggccagctg gcgcagcgtg atcctgtcgc
      841 cgttcggtac gccctcgacg taccggccga tcggatcgtc caggcggacc ttcccccggt
      901 ccaccagttg cagcagcgcc gtcacggtga acgtcttcgt ctcgctgccg atgcgcgtgt
      961 acaggtccgg cgtcatcctc cggccggtct ccttgtcggc gaccccgaac gaacggacgt
     1021 aaccgcgctg ccccggcgtc cagatgccga ccgtcacgcc cggcaccttc gcctcgcgca
     1081 tcacccgccg tacggacgcg tcgagttgac gtgtcacgtc gggggagagg gggcggacgt
     1141 ccggccccga gggggacggg cggggcgtac cggcggcggg cgcggacggc acggaggcgg
     1201 gtgccgcccc tgccgtgcac ggcgcgacca gcgtgccggt cagcagtgcg accatggcca
     1261 cccggcgcag gcgtacggac gtgggcgaca tgggctgact ccaagcgcgt gggagacgac
     1321 cgtgcgcggg gcggacgtcg gagcccggac cttcccagca ggacctgctc ggcaggagct
     1381 gccgccgcgc aggaccttcc cagcatagga gcggcagccg cccggcgccc gtcggccgga
     1441 ggccaccgct cacgcccccc gccccgggcc ccggtgctcg tccgggggcc gggcaccgcg
     1501 cgaagccgga cgcgcgaccg ggtctgcgct cggtggagcc gggatgccgg tcgggccggg
     1561 cctgtgctgt gtggagccgg gatgcctgtc cggccgggcc cgcgctctgt ggacccggat
     1621 gcccgtggac cggccctgag ccctgcgcag aagcaccctc gtccgacggg cggacgggcc
     1681 cggtgcgggc gatggcctca ccctcgcccg gcgcacgccc gagcgctccc gccctggcga
     1741 ccggctaccg cccgcacagc ggagcgagta ccgccagcgt gccgttggcc tgctgcaacg
     1801 cctcctccag ggtgcccggc gcatgcagcg tgccggtgcc gtcgggcggg accagccact
     1861 ccagggagcg ggcgggccgg tacggcggtg gcgcggcgac ccaggagccc ttggtcgcgt
     1921 accgcagtcc ggcgcccacc cagcccccgg acgggtccgg cggcacgaag aagccgaccc
     1981 ggcccgccgc cgtgtccacc agcgtcggcc ccggcaccgg caggcccggc cgccacagca
     2041 ggtccagggt gagcagtccc aaccggtcgg ggacgctcag cacgtcccag aagcggcccg
     2101 cctccagcag cgcgatgccc tccccatggt cccattccca tttgcaggcg cgcgggtcgg
     2161 ccgacgccgc ggccagccac tccacgcccc gcatccacat cgtgttcgtc atgcactgct
     2221 ccgggtgtcc tcgctcgcct gcccgcgtgc agggaacggt ggtgaccggg cacttcgtgc
     2281 ttccgcacgc caacccggca tatgcatggt tgtagatatt tctacctggc ggaaggggtg
     2341 gcgtgccctg gcgtttgagt cgggacgttc gaactccgct tgccggttcg tcagttgagg
     2401 ttccgcggtg cgtcactcgt tcggtgatcg agggatgcgg gaacgctcga ttctgtcgct
     2461 ccagcaatcg attcgagcgt cagatgttga ttgaggaggt ctttcagccg taaggtcacg
     2521 gcattccgtc gcccgtctct gccgaggtgc tccatggacc gcacgcgtct gcacgctctc
     2581 ctggcccgcg agagcgccga ggccgcacgc cgcaacccgc gctcccgggc ggcctacgcg
     2641 cgcgccgacc acctcttcgg ccgggtgccg atgacctgga tgaacaagac cgccggtgcc
     2701 ttcccgcgct acctggccgc ggcgcggggc gcccgggtca ccgacgtcga cgggcaccag
     2761 tacatcgact tctgcctcgg cgacaccggt gcgatggccg gccactcgcc cgcgcccgtc
     2821 accgaggccg tgcaccgccg gtacgccgag ctgggcgggg ccaccgccat gctgcccacc
     2881 gaggacgccg agtgggtcgg cgccgaactg acccgccgct tcggcctggc ccgctggagc
     2941 ttctcgctca ccgcgaccga cgccaaccgc tgggcgatcc ggctcgcccg ggccgtcacc
     3001 ggccggccga agatcctcgt caacagctac tgctaccacg gcagcgtgga cgagtcgctc
     3061 atcgtcaccg ccccggacgg caccggcacg ccccgccccg gcaacgtggg cgcgccctgc
     3121 gacgtgacgc tgaccagcag ggtcgccgag ttcaacgatc tcgccgggct tgagcgggag
     3181 ctggcgcacg gtgacgtcgc cgccgtcctg atggagcccg ccctcaccaa catcggcatc
     3241 gtgctgcccg aacccggata cctcgccggc gtccgcgaac tcacccggcg ccacggcgcc
     3301 ctgctcatca acgacgagac gcacaccttc tccgccgggc ccggcggctg cacggccgcc
     3361 tgggagctgg agcccgacct gctgaccatc ggcaaggcga tcggcggcgg catcccggcc
     3421 ggcgcctacg ggctctccgc cgaactcgcc gaacggctgc tggcccgcac cgacctcgac
     3481 ctcgtcgaca tgggcggcgt cggcggcacg ctcgccggca acgcgctgtc ggtcgcggcc
     3541 acccgggcca ccctcgccca cgtcctcacc gacgaggcgt tcgcccggat gagcgcactc
     3601 gccgagcgtt tcgaggcggg cgtccgggcc ggcctcgacg cgcacggtct gccctggtcg
     3661 gtcagccggc tcggcgcccg caccgagtac cgcttcacct ccccggcgcc gcgcaccggc
     3721 accgagtccg cggcggcggc cgaccccgag ctggaggact tcctgcacct ctacctcgcc
     3781 aaccggggca tcctgctcac cccgttccac aacatggcgc tgatgtgccc ggacaccacc
     3841 gagaacgacg tcgacacgca caccgaggtg ttcgccgccg cgctcgccga gctggccggc
     3901 tgagcaccgg ctgcggaagg gaaccgctcg acgtgaagga catggacgac atcgaccggg
     3961 ccatcctgcg cgaactgcag accgacggcc ggatcgccta cgccgacctc ggcccgaagg
     4021 tcggactgtc cgcctcggcg gcccggcagc gcctccagcg gctgctggac tccaaggcgg
     4081 tccaggtggt cggcgtcacc gacccgatgg ccatgggcgg ccaggccatg gcgctgctcg
     4141 gcatcggcgt cgacggcgat ccgcggaccg tcgccgacgc cctcgccgag cgccccgagg
     4201 tcgtctactc ggtgctcacc tcgggcggct tcgatctctt cgccgaggtg gtcgcacccg
     4261 gcccgaaggc gctgctcgac ttcgtcaacg acgtggtccg ccccctggac ggcgtgcgcg
     4321 agatccggtc cttcccgtac ttcggcatcc acacccatcg cttcctgtgg gacgtgggct
     4381 gaccggcggg ggagaggagg gtcagccggc cggcggctcg ggtgccagca ccaggacggt
     4441 ggcgtcgtcg cggaccacgt agcgccgccg gagcaggtcc gcccagaccg cgccgggcag
     4501 ctcggcggac ggggtgccgg ccagggcggc cagccgctcc ggcagcggat agaaggtgcc
     4561 ggcggcgtcc cgcgcctccc acaccccgtc ggaggccagg aacagccggt cgcccgggcc
     4621 gagcggcacg gtgacctcct tcggccggtc ggcgtcgagc agcccgatgc ccagcggcgg
     4681 acccggcgcg acggcgacct cgcgggcctc ctccccgtgc agcagcaccg gtggcggatg
     4741 accgcaggcc accacccgga ccgcggccga gccggcggcg aactccagca gcagggcggt
     4801 cgcgaacagc tcggcgtgcc gtacgtccgc cgagtccacc gccagccggc ggtccagccg
     4861 ggccgccacc gactccaggt ccggctggtc cagggccgcc tcccggaacg cccccagcag
     4921 cgacaccacc gtcgccaccg ccgacagccc gtgcccctgc acgtccccca tgaccgcgcg
     4981 cacgccgtac ggcccctgcc gcacgtcgaa gaagtccccg cccaccagcg tcccgtcctg
     5041 cgcggcccgg tagaaggccg cgcagccgac ccggccgacc cgctccggca gcggcggcag
     5101 cacggcgctg caccgcctcg ccgatcgtcc gctccgtgtc cagctgggcg tcccgatgac
     5161 tgcgcacgaa ggacacgaac acgctcagcg cggccacgaa cacgatggtg agcagatcgg
     5221 tgtcgccggg gcggttcaga tgcgtggccg gcacgttcag caccacgacc acgcccaccc
     5281 cgagcagacc ggtcgccagc gggccgtacg acaggaccgc cagcggcggg atggcgccca
     5341 gcaggaaacc gagatcacgc gcgtggggcg tggccagcgt ggccgagccg acggccacca
     5401 gcagcagtac gggcagcacc cgcacccacc acggtggcgg cgcgccccgc agccagccgc
     5461 gatcctcccg gtgcccgcgc ggcgaccagc cgcgcaccga tcccacatcc ccaagctacg
     5521 ccgccggggc ggcacgccgc gcggaaaagc ggtggacgcc cgcccgcccg tccccctagc
     5581 ctgagcccgc cacgcccgag ccggacggaa caaggaggtg agtgtcatgc acgacagcag
     5641 caggcgctcc cctctccccg tgccgcgggc gtgacacggc tgagccgacc gggagcgccg
     5701 tacaccgtac gcatcctccc ggaggaacca tgaccgacct ggtcgtccgc acgctcgacg
     5761 agagcagtgc tcagcttttc cgtaccatgc ccgacccgct cgccctgggc gagcggcacc
     5821 ggtacacccg ctaccgcccc gactggcagc gcgtcgccgt gcgcgacggc cgcaccgtgg
     5881 cgcgggccgc ctggtgggcc ggacccgagg accccgagcc gcggctgatc aactggttcg
     5941 acgtcgcgga gggggaggag gaggcgggcg ccgaactgct gcgcaccgcc ccctggggga
     6001 ccgccgaact cgaactcgac ctgcctgccg gctggcgcga cgacccgcgg ctgcgggccg
     6061 cggccgacgc ccgcgccgcc gccgcacgcc gggccggtta cacccccctc gtggagcgct
     6121 tcctctaccg ctggaccccc gaccgggggc tgcccgagcg gcccggccgg ctcgtcttca
     6181 cccccgaacc ggacgacgcg gtgttctacg agctcctgcg ccgcgtcagc accgccacgc
     6241 tcgacgcgca cgcgcgccgg gccatcgccg agggcggcgt cgaccaggcg gcccaggagg
     6301 acctggactt cttccgctgg ttgccgtccc cgcgcgactg gtggcagctc gccctgacac
     6361 cggcgggcga gccggtcggc atccacatcc ccgcgcgcaa cccctcgggc ccgtgcgtcg
     6421 gcttcatcgg tgtggtgccg gagcaccgcg gccacggcta cgcctacgac ctgctggccg
     6481 aatgcaccca cttcctggcc ggacagggcg ccgagttcat cgccgccgcc accgaccagg
     6541 gcaacgtccc gatggccgcg cacttcacca cggccggcta ccccgtcgta cgggaacgcg
     6601 tcacctactg ggccgacggg ggtcccggag ccgggtgacc ggcgagcctg cggacggtac
     6661 cggggggccg ccgcccccgg tgcccgggcc gctagggcct gtcgtccgga tcatgccggc
     6721 gtcgcggggc gctagtccgt cccggccgcc aggcgggcct ccgccgcggc caggatctcg
     6781 gtgacccgga ggccgaacgc ggcgtcgcag gagtgcggcc ggcccgtgcg ggccgcccgc
     6841 accagcgcgt ccgcggcccg gtccagcgcc ggcaccgctc cctcggaact gcccggcagc
     6901 accgtcacac ccgcctcgcc ccgcagttcc acatcggccc cggccgccgc cggcggcgcg
     6961 gtcaggctca gcgtgagggt gctcgacgcc ccggtggcgt ggtcgagcac caggtgcacg
     7021 gtgtccgccg gaccgtgtgc cgccgccacg acgtgccgga cgtcgccgag gaccggcagc
     7081 agcaccgaca gggcgtgcgg gccgacgtcc cacagcgcgc ccttctcccg ccgccacggc
     7141 gagtgcgcga acgggctgtc gctggtgaac accgccccca gccactgggc ccgggcggtg
     7201 aaccagcccg acacggcggc ctgttcctcg atccaggcct ccggctcctt ctggaagcgc
     7261 gcggtgaaga acaccaccga cgccaccccg gcccgctcca ccgcctccgc gacggcccgt
     7321 ccctcggcga ccgacaccgc cagcggcttg tccagcagca gatgacggcc cgcccgggcc
     7381 gcccgcaccg ccaactcggc ctgcaccgac ggcggcaggg ccatcgccac cgcgtccacg
     7441 tcggccagca gcgcgtccac gtcggcgtac gcggcgacgt cgtactgctc cgccagcgcc
     7501 gtggccgcct ccggccggcg cccccacacc ccggcgaact ccaggccggt gtgtccggcg
     7561 agagcgggag cgtacgccgc ccgcgcccag ggacccgttc ccagcagccc gatgcgcatg
     7621 tcgcgttcct ttctccgagc cgatccccgc accctcaaga tgctgcgctc cggtcgccct
     7681 ccgcacacct gcggcccgga tccccgtctc ccgcgagcca gtcggcgatg gtggcggcga
     7741 tcggctggcc ggtgtccatc tccacgaagc cgaactggcc ggactgattg cactccagga
     7801 accaccagat cccgtcggag tcctcagcga agtcgaaagc gccgtacgcc agttcggcgc
     7861 cggtcatgta gcgcagcacg ccctcggcga cgcgcggcgg cacgtccgcg ggcagccagg
     7921 gagagaccga cggggcgaag cgcacgtcca cgtcgtccgg atgggcgtcc ggatcggcgg
     7981 gcttgcgggc ggccagcagg gtgccgccga cgacggtgag ccggatgtcg gcccgcttgg
     8041 ggatccgccg ttgcagcagg gtcgggccga aggccaccgc ggtgaagtcg gtgtccggtg
     8101 ccacccggct ggtcggcacc gcccggggcg gctcctgcgg atgcgcgccg gagaccggtt
     8161 tcaccaccag gtccgggaag cgttccgcga actcccgcgc cgcctgcggg aacgtcgtga
     8221 cgagggtggc cggcaccggg aggccgctgc gctgggccag atgcagctgc cagggcttgt
     8281 gccgggcccg gcgggcggcg tccggatggt tcatccagcg ggcgtcgctg caccgcagca
     8341 tgccgtacag cgcctgcgag gactcctccg tcagccaggc ggacggctgg gcggcgcggg
     8401 cggccgggac tcccggcctg cgcacccaga cggagcgcag gccgttgatg ctcaccaggc
     8461 gcccgccgac ggagagatgt ccgcggcagg cgccctgcgc gtactcgccc gacagcgcca
     8521 ccccgttggt cagatcggcg gggtcgagcc ggacgacggg caccccggcc tcgcccagcc
     8581 ggaggaccac catgtccgcc gtcacgtcct cttcactggt caggatgagc acggtcatct
     8641 gtcgaagccc gcgttcagtc gtcgaagtgg gtcttggaac cggcggtcga ggtcgtggtt
     8701 ccgagcgctc tcaaggtcgc gtggtcggtg gcggcgatcc gcccgtccgg gaggacgttc
     8761 aactgcagtc cggagtcgta cgcgtacgga gcggtgacat ccaactgcac tgcgggccgc
     8821 gcatagttga gggtgaacgg ttgcatggtc tctccctgat taggctttca cgtccttata
     8881 cgagtcgaac gggtgattgg tttcctcacg ttgcgtgatc gcggtagggg cgcggatgcg
     8941 cgggggtcat cccgcgagcg ccccgcgcgc cgccgccagc gcctgctccg cgtacccgcg
     9001 tccgaacagc accgcgtgca ccaggagcgg gaagagctgg tgcagtccca cccggtcccg
     9061 ccagccgtcg gccagcggcg ccgcctgccg gtagccggcg agcacccggt ccagatgggg
     9121 acagccgaac aactggagca tcgccagatc ggtctcccgg tgcccgccgt gcgcggccgg
     9181 gtcgatgagc cggacctcgc cgtcggcgcc ccacagcacg ttcccgttcc acaggtcgcc
     9241 gtgcagccgg gcgggcggct cggccggacc cgcgaggtcc ggcagccggg cgcagacccg
     9301 ctcgaacacg gcggcctcgc ccggccggag cgtgccccgg tcgaccgcgc cgcgcacata
     9361 cggcaggacg cggtgctcgg cgtaccagcg gggccagtcg ccgcccggcg cgttccgcag
     9421 gggagcgcgg ccgatgtagg cgtcctccgg gccgcccggc ggcggtgctc cgaagtgggg
     9481 tgcgccggcc ctgtgcagcg cggccagggc ctggccgaaa cgcagcgccg cctcggggtc
     9541 gggagacccc gtcggcaccc gttcggtcac catccagcgc tcgtcgtgcc cgagcaccgc
     9601 cggcacccgg accgcctcgg ccgcggccag ccagcgcagc cccgccacct cggcgcgcac
     9661 cgcccccgga ccgtcgccac gcttgaccat caccggtgtt ccgccgtcca gcagtacttc
     9721 cgcgggcgac cccgacccgg gccgggcccc gctgaccggg cgcccggtga gccgggccgc
     9781 cacctgtcct ggatcctcgt ctcggttgac cacgggccca gggtacggcc cccaatcaag
     9841 gccgctcgcc gggcacttca ccggttgata cgactgtttt cagccaaacc caggcggtaa
     9901 ctacccgtgc tgatctcgta ccgctagcgt gatcccgccg cgtcgccaca ccgggggcac
     9961 agggcccgca gggactagcg cgcggcggag gattcctccc gtgaccacag catccgtgct
    10021 gatggccgac gtcttcgaag tccagccgta cacctcccac tgcgaggtca tcctcggtga
    10081 gggcgcacac gcggtgatcg gtgtctcccc gggcaacagc tacttctcgg cccggcgcct
    10141 gcacgacctc gcccgctggg ggctggacca cttcgaccgg gtcgacttcg tctacaccga
    10201 cctgtacgtc gccgagatgt acgaggcctc cggctacccg ccggacgagg cccgccgcaa
    10261 ggccgtgaag aacctgcgcg gggtgcgggc caaggtccgc gacgccgtga cggcggccga
    10321 tccggacggc acccggctgg actggcaccc gatgtcggag ttccgcacca accccgccta
    10381 ccaggagatc caccggcagc tcaaggcgcg actggtctgc gacggctcct tccgggccgt
    10441 ctgcgaggcc ctggtgaatc gtttcctcag cgcgcgcggc gagacaccga ccgagcggca
    10501 gcgcgccgtg tgcctggagt acgtgtgcgc cgaggccccg ctgttcctgg acaccccggc
    10561 catcctcaag gtgccctcct cgctcaactg ctaccaccaa ctcctgccga tggccgagct
    10621 gttgtactcc cggggtgccg gcctgcgcgc ctcccgcaac cagggccacg ccatcgtcac
    10681 ccccgccgcg ccggaaggaa ccacggcatg accaccgccc ccgacacccg taccgaccac
    10741 cctcccttgc cccgcttccc gttctcctgg gacggcaccc gggtgcctgc cgaggtcgcg
    10801 gccctgcgca ccgccacccc ggtacggcgc gtgcggacca tcgccggcga cgaggcctgg
    10861 ctggtctcct cgtacgagct gtgcgcgcag gtgctcaagg acgaccgctt ctccctcaag
    10921 gacacctccg cgcccggcgt gccccggcag tacgcgctca cgatcccgcc cgaggtcgtg
    10981 aacaacatgg gcaacatcac cggggcgggg ctgcgccgcg cggtgatgaa ggcgctgagc
    11041 cccaggacgc cgggcctgac cgagtggctg cgcgccgaag cccaccgcct ggtggacctg
    11101 atcaccgccg acggaccgac ggccgacctg cgcggagcgt tctgcgagcc gtactcggcc
    11161 gggatgcact gccggatcct gggcatcccg cagaccgagg ccccggcctt cctgcgcagc
    11221 ctggacatcg ccttcatgaa ctccccgtgc ccggtcaccg gcgcccggct caactgggac
    11281 cgggacctcg cccggatggc ggccctgctc gacgacccgg cgacgggcgg cctgatgggc
    11341 gaactcgccg ccctgcgcga cgaccccggc cacgcgcacc tcaccgacgc gatgctggcc
    11401 accgtcggcg tcaccctgtt cggcgccggc accgtctcca cctcgggctt cctcaccatg
    11461 gccctggtct acctgctcac ccaccccatc gcccgcgacc tgctgcggga ccgccccgac
    11521 ctgatcggcc cgggcgtgga ggagctgctg cgggtgaacc tctccatcgg cgacgccctg
    11581 ccccgtctcg ccctggacga cgtccggctc ggcgacgtcg acatccgcgc gggcgacctc
    11641 gtcctggtgc tggtggaggg cgccaacctc gacccggaca ccttccccga cccgcaccgc
    11701 ttcgacgtcc accgcgacaa cgccgccgac cacctctcct tcggcggcgg cgcccactac
    11761 tgccccgcga ccgcgctcgg ccgcgcgcac gcccggatcg ccctggaggt cctgctcgac
    11821 cggctgccgg acctcgccct cgcggtcccg ccgggccaac tggtgtggcg caccgggttc
    11881 atgaagcgga tccccgagcg gctccccgtg acctggtgac ccacggcgcc cgtcgcccgt
    11941 acggccgccc cggccccgcc gtacgccgcc ccccccccgg gcggggggcg ccgggcgggg
    12001 cgccgggccg cagtgccctc aacggccgcc ggggtacgtc ccgcgggtca ggcccaccgg
    12061 attcccggcc ggcatcagtc ccgcctcgtg gacggcgtgg gccagcggct ccagcagcgc
    12121 ggccaggcgc ccggcccgct cggcgcccag tgcggtccac ggcccttcgg ccgcggcgtc
    12181 ggtgagcgcc tcggcctccg tgcgcagcgc cgcccccgcg ggcgtgagcg agccgtcctc
    12241 cgcgagccgg ccgtcggcgc gcagccgtgc ctcggccgcc gcccattcct cctgcggcca
    12301 cttccgggac tcgcgcagga gagccgcgtc cgtctcgccg gccgccgcct tgagcaccat
    12361 ggcctcgacg ggaccgatcc ccagggcgac cagcaccgcc acgtgggagt cgccccggtg
    12421 ctcgcgcagg gtcgtcagcg cctgccacag gcgtgcggtg ggccggtccg gccgttcgag
    12481 cgcctggttg gcagcggcca gcaccctgcc cgtggtgtcc gccgccgcgg cggtctccca
    12541 ggcgaggtca gcggtctgcg cgaacgcggc ggagccgacg gtgtccgccc cgaacagccg
    12601 ggtcatcgcc tcgtccaccg cctcctgccg ggccgccacc acgtccgccg gggtggcgta
    12661 cgtccaggcg tccggcagtg cccgggccac ccgcgtcggg tggaagacgt agaaacagct
    12721 cgtcaccacc gacgggggca ccgcgccgag cggggcggcg cgcagcgcga agtaccccat
    12781 ccagaacccg cgcatcccga gccgctgcgc cgcccgctgc gcctccggcg cgaagtacac
    12841 gagatcgtgc accggctcgt accgctccca caggaaccgg gccattccgt ccgccactgc
    12901 ttcctcccac cgcgtcggcc tgccgtgccg tgtcggcacc agcctgcgtt atgacggttg
    12961 tcataacaag ggggtggcgg tcgcgacggg agagacggcg gtcacggcgg gagggcgagg
    13021 ggattggccc ggacgagggg tcccgacccc ggagcactgg ggcagacggg tggcgtggtg
    13081 acccggctgg gcggctcgga tggtgggagc cgggggcctc actgacggtg gttcatgtcg
    13141 aggccgggtc cacccagctg atgaggtatc cgctgcccgg tcgcgacgga aggacatcac
    13201 tatgcgctct gcccgcatgc tcctagcgac ggcggctgcc accgccgccc tggccttcgc
    13261 cacgcccggc gccgcgttcg ccgtgccggc cgagcacgac gacggccgtg acgactcctc
    13321 gtacagcaag gagcacgaca gcggctccga ccgcgaggac aagggatccg acagcgacca
    13381 cgacaagaac tacggcaaca agcgcgacgg cggaggggaa cacgacggcc cgcgcggcgg
    13441 aatgcacacg ggtggcggag cgctcgccgc ggtgcgcagc gacgaatggg gctcgggcga
    13501 cgacagccgg ttcgaccccg agagctaccg ggacaagggg ggccgcgaca gcggggagga
    13561 gaagagcgag aagggtgaca agggcgaccg gggcgagaag ggcgagtggg gtggcggggg
    13621 cggccacgac cggccgcgcg gtggcatgca caccggaggc ggcgggctcg ccacgcccgg
    13681 tgtcaccgcg agcggactcg ccgtgctggg cgtaggcgcc gccggcgcgt acgcgctgcg
    13741 ccgcaggaag gccgccgagc cggcgtcctg acggccggta cgtcccaggg gctgcggacc
    13801 ccgccggcgc gcaccgcgtc ggcggcccgc gccccctgcg ccccgccccg gacgccggga
    13861 ccggcgccgt ctccctccca ccctgatccc cgtgctgccg cgctcgagtg aggtggtgtc
    13921 cgatggcagc agatccctcc tccccgaccc ccgcaggacc ggcagcggac gggcggcact
    13981 ccggccgtgg cgggcggctg acgctgtggg gagtggcggc cgtcttcctc gccgtcagca
    14041 tgttcggcgg tcatgagacg cccgatgaga caccggcggc gccccgggcc tcgggcgccg
    14101 gtgccgtcgc gccggccgac ccgcggcagc ccggcgagcc acggcagtcc ggcgagccac
    14161 cgcggtccgc cgagccgctg ccccggtccg cgccgacccg cctgcggatc ccgaagatct
    14221 ccgtggacgc cccgttcacc gccctggcca tcggcgcctc gggccagttg cagccgccgc
    14281 ccgccgccga caccaacctc gtcggctggt acgccgacgg cacctcgccc ggcgaggagg
    14341 gcaccgcgat catcgccggg cacgtcgaca cgatgacctc cgcggccgtc ttcgccgagc
    14401 tggaccggct gcggcccggc gaccggttct ccgtcgagcg ggccgacggg cgcacggccg
    14461 agttcgtcgt ggacagcgcc gagaccttcg ccaaggacga cttccccagc gagcgggtgt
    14521 acgcggacgc ctcgcgcccc gaggtccggc tcatcacctg cgccggggac tacgaccgca
    14581 cggtgcggga ctacacggac aacctggtcg tcttcgccca cctggagtga gccgccgggg
    14641 ccccggtcag gcggcgcggc cggcgaaggg gccgtccgcg gcgaaggcca gcgccgcgaa
    14701 ccgttcgccg atcctgcggt gcccggcggt gtccgggtgc agtccgtcgg gcagcggcag
    14761 ctcggcgaag tcggcctcgc cgtacagctc ccggccgtcc aggtggtaca gccgcgggtc
    14821 ctcggccgcc cgctcgcgca cgatccgggc cagttcctcg cggaccgcct ccagggtgag
    14881 cttcccggcc gcccgctcgg ccggatcccc ggtggcccgg taccgcatcc gcccctcgcc
    14941 cagcgctgcc aggtccatgg cggtggggcc gggggtctcc tcgtgcatcg ggcacagcac
    15001 cggcgagacg acgagcagcg gggtgtcggg gtggccctcg cggacggtgt cgaggaagcc
    15061 gtgcacggcc gggccgaagg cgcgcagccg catcacgtcg gtgttgacca cgttgatgcc
    15121 gagcttgacg ctgatcaggt cggcgggtgt gtcacgcagc gcgcgggcgg tgaacgggtc
    15181 cagcagcgcg ctgccggcca gtccgaggtt gatcagctcc acgccgccca gggacgcggc
    15241 cagcgccggc caggtggtgg tggggctcgc cgcgtcggag ccgtggctga tcgaactgcc
    15301 gtggtgcagc cacacccggc ggccccggtc cggtacgggc tcgacgggcg cgtcggcgcg
    15361 cagcgcgacc agctcggtcc tctcgttgtg cggcagccag atctccacgt ccttgtccgc
    15421 gtccggcagt ccggtgaagc gcacggtgcc gaccgggccg ggacggtgct cggcggtccc
    15481 ggtgcccagg tcgatggtga gggtgtcgcc ctcggcgagg gaggcgctgc cggccgggcg
    15541 tccgtcgacg agcagctcgt acacgccgtc ggggcggggc ggtacgccgg ggtagacccg
    15601 cttggtgggc agggcgtcca gctccaccgt ggtggcgcgg gtgcggaagg ccagccgtac
    15661 gccggagggc tgggactccg ccagggccag ctgcgggtcg gcgcaccggg cgcgggcccg
    15721 cgcgggcagc cggtgcggca gcaggccgtg cgcggtgcgc tccagttcga gggcgccgcg
    15781 tatcaggccg gcggtgaggg ggatggtgtg catcgtgtct gcctgggttt ccgggtgtct
    15841 caggggtggg cgggccaggt gcgcagcagg gagtcgaggg cgtccaggat ccgggcccac
    15901 gactcctcgg agtcgggcgc gctgtggctg aagccgccgg ccgtctccag gctgacgtag
    15961 ccgtggaaga cgctgccgag gaggcggacc gcgtgggtct ggtccggctc ggtcaggtcg
    16021 tagccgcgca ggacggccct ggtcagctgt gcgatccgga cgcccgcgct gccggcggcc
    16081 gtcgcggagt ccagggggtg gcgggccgcc gcgtagcggc cggggtgggc gcgggcgtag
    16141 tcccggtaga cgtgggcgaa ggcgccgagg gcgtccttcc cggaccggcc ggccagcgct
    16201 tcggcggcac ggtcggccag ctcctccagg gcgagcagcg cgatccgcgt cttcaggtcc
    16261 tgggagttcc tcaggtgcga gtacaggctc gcgaccttga cgtcgaaccg ccgggccagc
    16321 gcggagaccg tcacctggtc gaagccgacc tcgtcggcca gttccgcacc ggcgcggacc
    16381 agacgttcgg tggtcagacc cgcacgcgcc atcgtcgctc ctcccggcct ccgcacgctt
    16441 cccggctgcc agaaggagta tgagacttcc taaagggttt aggcaaatgg gatcagtgtt
    16501 taggtcgtgc gcggcgcggt cgtggactcg gggaccacca gggagaaggg gccgacgaac
    16561 tcctcctggg ccgccggtgg tccctcgcgg cccctccgcc accatcgccc gggcccgccg
    16621 ggcgccgcgg ccatggccgg cgccggcagg ctccgcaccg gccgtggggc ccgcgggcag
    16681 gccgagggcg gtaaccaacc ggcctgcttc gcccgcctcg gctccgcgcc aaggcgttct
    16741 gcacgcggac cgtcgagcgg ctgggcgagg ctgtacgggg aggctgccgg cactggcggc
    16801 ctttgtggcg gcatcgcgat tacggacgtc ggcccctgtg acgaccgcgg cagtgtttcg
    16861 tgcgagaccc ccgtgcgacc agcgggtatc catgtcgctt gtggggctac gcataggttg
    16921 cgttggcctg cgtccggtat gtctgcctag cctcgtgagt ggaagtgatc aagccggtca
    16981 ctgacgcgga tatgaggagg tgctggacat ggccgagcac acgctgaagg acaaggtcgc
    17041 ggtcatcggc gggggcgaga agaacctggg cgggctgctc agcaggacgt tcgccgaggc
    17101 cggggccaag gtcgtggtgc actaccacac ctcggagaag gaggcggagg agaccgtcca
    17161 ggccatcagg gacgccggcg ggcaggcggt gtccgcgcag ggggacctga cggacgtggc
    17221 ggctgtgcgg cagctgttcg acaccgcggt ggacacctac ggcggtgtcg acgtggcggt
    17281 gaacaccacc gggatggtgc tgcgcaagcc gatcctggag accaccgagg acgagtacga
    17341 ccgcatgttc ggcatcaacg ccaaggcggc gtacttcttc atccaggagg cggggcgccg
    17401 cctgaacgac cacggaaaga tcatcagcct gggtacgtcc ctgctggcgg ccttcaccga
    17461 cggctactcc acctacgcgg gcggcaaggc gccgctggag cacttcaccc gggccgcggc
    17521 caaggagttc gccgaccggt cgatctcggt gaacgtggtg gccccgggcc ccatggacac
    17581 gccgttcttc tacggccagg agactccgga gcgggtggaa ttccacaagt cgcaggccat
    17641 gggaggccag ctcacccaca tcgaggacat cgtcccgctg atcaggttcc tggccaccga
    17701 gggctggtgg atcaccggcc agacactgtt cgccaacggc ggctacacca cccggtaagc
    17761 ccccaccgcc ggggccgccc gcatcggcgc ggccggcccc gccagcaagc gccgtaccga
    17821 ttccggcaca tgggaagaca caggatgact gccgagctga ccgatcccgc gatagccggg
    17881 ttcgtcgccg cggtcaacgc cggcgacaag gaggcgttct tcgccgccct caccgacgac
    17941 gccacgatgt ccgacgacgg caccgaccgc gacctgcgag agtggaccga gcgcgagatc
    18001 ttctcttcga acggccgcat ggacgtcgag gaggtctcca ctgacggccg tacgctgacg
    18061 gccacctaca ccaactccac ctggggcagc atgcgcaccc ggtgggtctt caccgtcacc
    18121 ggtggccgta tcagccgctt cgagaccggc cgagcctgac catccccaag cacctgcttg
    18181 agcgtctggg catggtcggc ctccttgcac ccccgcaccg gcccgccgcc aggcggatga
    18241 gacgaaagaa acgcccgatg agcagcagtg acagtgtggt ggagcgtgat ggggcgctgt
    18301 ggcgggcgat gcgcgggcgg gatcccggtg aggagcaccg ggcctccacc ccgctggagc
    18361 tcttgttcga cctgacgttc gtggtcgcgg tctcgcaggc cgcagcccag ctccaccacg
    18421 ccctggcgag ggcacgtcgg cgccgggctg ctgggctacg ccgccgtctt acggcctgct
    18481 cgtcgcggcc gacgcgctgg tggtgttcgc cctggcgctc gccgcgtcca cgctcggcgt
    18541 cggaggtgca gtgctgggca tgggcccggc cgtcgccgcg gcactggccg ccaacctcgc
    18601 cgtctaccgc caccgcagga ggtgagctga gggtgggctt ggatctgaac aagctggagc
    18661 acctgatcgc ggtggccgag gagggcagca ttacccgcgc cgccgcccgc ctgcacctgt
    18721 cccagcaggc gctgtccacc tccatccgcg tcctggaacg cgaagtgggc gtccccctgc
    18781 tggagcgcgc gaccaccggc atctccctgc tgcccgccgg caccgccctc gtcgaggacg
    18841 cccgcgtcct gcgcggcacg gcacgctccg ccctccagcg cgcgcgccgc atcggccgcg
    18901 gcgagaaaga agtcctgcgc ctgggccaca ctccggccgt caccggggag gaggtcatcg
    18961 ccctgctgcg gcaggtgact gccgcccacc cccacctggc caccgacgtc aaccagcgct
    19021 acccggacga actcaccgct gctctcctgg cgggagacct cgacatcgga ctgtgccggg
    19081 ccatgccccc gccgcacgga ctggcccgca ccaccctggg ccaccagccc ctcaacatcg
    19141 cggtcgccgc cgaccacccc ttctccacac gcccgtcggt ggccctggcc gaactcgccg
    19201 accagcactt cgtcgtctgg ggccagcccg gccactccgg ctacaccgac ctgctcatca
    19261 gccactgccg cgcagccggc ttcgaacccc gcaccgaacg cacccccctc cagggcaccc
    19321 cgcccgccac cgccgtcatc ggcaccgacc gcctcgcctt cgtcaccaca cccccaggcc
    19381 ccgccgccgg cggcgccgtg cgcgtcctcg ccctcgaccc gcccctgtac gcacccctgc
    19441 acgctctgta ctctccgcgc accaccagcc ccgccaagga caccttcctg gccactgcca
    19501 ctctgtaacc ggaccagcgc cgccctgcac ggccctgaca acgagcttgt gcccgatccc
    19561 ggttgcgggc ttcaggactc ggtgcggcgc ggggctcccg tcggtgcaca ccgccttagg
    19621 agcggcccgc ctcctccgct ccggacgaga gggggcggct ggcgacggtc acgggcccgg
    19681 cccggtggga ggacctgttc accgcaccgg cgatgagtac ccggtgcagt tcgtacggcc
    19741 cgcggacacc aaccggccgc cctgggcggc gtacgggggc ggcacgtacc gggggacggt
    19801 gagcggcgag ccggacggct ggcggcccga ctggcgggtg cagatcacgc atgcggccca
    19861 ccggaacttg gacgacgtcg tgctgccctg cggcgtcccg cgtcctggcc gcgcgagcgc
    19921 gtgcagtccg cacgctgggc ccgcactgca cgctccgctg ccgggctccg acgccctgcg
    19981 cgcgttcgca gcggacgccg ctcaccgcgc cggcacctgc ctggacgggc aacagctccc
    20041 tgccgtcccg tggaaccccc gtgcagcggc gcccgagagg cggcaggttg aagaggcgat
    20101 caccatccgc gccgtcgact tgccagtggc acccaggacc ggggcgccac cgccaccgga
    20161 cgaaagagcc gggctcccgg tggacgcgag ccgtcccact ggctcaccgc taccgggagc
    20221 ttggcccgtc acctactgac gcctaccacc aactggtgca ccggacgttt ccggtgctgt
    20281 cgttcttgcc gcaggcgcgc atcagattgc cgccgttgta gcgcgcatcg gtgaacgtgt
    20341 cggacccggt ctggacggtc gtcacgttca acgggccctc ccaggtcctg ccgccgtcgt
    20401 aagagcggtc cacccatacc ttgtcgcccg gatcggcgtt ggtgatccgg ccccacgagc
    20461 agcggaggga cgggctgtac cgcagttcga tcttgatcgt gtcgaccgtt gcggtcctcg
    20521 ccgtgtaagc gtcgctcttg tggtagcagg tgcccgctgc ggcctggacg ctcggttcgg
    20581 cctgggcagc gcccgctgcg ccgagagtgg agaaaagggt cgcggcgacc agcacggtgg
    20641 ccctggcgac gttgccgcac agaagtttca tcgttcctcc gttgttcgta cgcctcgtca
    20701 cccggtcccc t
//
