LOCUS       NZ_AP024135            22194 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8245340
            Orig. end                         :: 8267534
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="34"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22194
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12194](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12194
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            1498..3027
                     /locus_tag="K6K39_RS36335"
                     /old_locus_tag="EASAB2608_07440"
     CDS             1498..3027
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669253.1"
                     /locus_tag="K6K39_RS36335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07440"
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_221335364.1"
                     /sec_met_domain="Polysacc_synt (E-value: 5.3e-16, bitscore:
                     57.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPEATAPGSAAPSVAAAARGGWWGVAGAAVNAVFAFVFVGLIT
                     RAVGAQGAGAVFTGVAVFTILSNTCKLGADTGLVRFVSRDIAVGGGRSVGALLRAAVVP
                     AAVASTVAALPLLLCPAVATTLLPHLPPSDAVTLVRLFGLFLPVATVGLVLLGATQGHG
                     TVLPFVGVEQIGKPVLRVAVAVPVACFAPGLLALAAAWLLPALAGTVVAWLALRRCRAA
                     RGTARPAPRGAVPWRGFWSFAAPRAISSVFDFSAVWIGVVLLSALATGAEAGVYTAIGR
                     VVTAGTLLQLAIRLAVAPQISRLLAVDQVAEARQLHRVSTCWVVLFSWPLFVLLAGFPR
                     TVLSVFGPEFVQGAPALVVLCGAAMVNVAVGNAQTVLLMSGRSSWHLAVTAAAFAVQLT
                     VGLLTVPKWGVLGAAVSWGAAIVVENLSAALLIRLRLGFTTVDRGYTTALGAALAVATV
                     LGAVRVLGGDTLSGLAAGMTLGMCVFGTSLWWYRRPLGVNELVGVLRRRAA"
     gene            3115..4668
                     /locus_tag="K6K39_RS36340"
                     /old_locus_tag="EASAB2608_07441"
     CDS             3115..4668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669252.1"
                     /locus_tag="K6K39_RS36340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07441"
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_221335365.1"
                     /transl_table=11
                     /translation="MRLRKLPSRAATRAVAATVLCSAALLHPALATADDGPRPAFTADP
                     LTTWQTNGIVWSLAAAHGVVYVGGTFDSVRPSGAEPGDREVPRRNFAAFDAVTGALLPC
                     APSFTGGEGTVRALKTSPDGRVLYVGGSFSRVGSTGVASAVALNTADCSLRRDFRPAVS
                     ATVRAIDTTDRRVYLGGDFRRVDGRTRQHVAAFTPQGTLLDFRARVDAPVRALSAVPSR
                     QRIYVGGDFETVNDRWAHALVALDATSGATVRSFPDWLPPGSVVKSIAQDDTRFYVAAE
                     GHGEGIFDGRIAGRLDDHRMVWKDDCHGATQAVLPYQGVLYSASHAHDCAGTPGGFPER
                     QDRQHLLAQSPRDRRILHWFPDTDEGRGERVGPRALAVARGILWVGGEFTRVNGAPQQG
                     LTRFGTGPDTGAPAVPALSLSAAEPGHVTLRWKASWDRDDAALTYRLYRDGRLVSRQER
                     SSTYWNRPWMSYTDSVDAGTRHQYRIEVTDGVNTSPKSPPLRVAVPGGTTAWTAGESAK
                     "
     gene            4665..>5078
                     /locus_tag="K6K39_RS36345"
                     /old_locus_tag="EASAB2608_07442"
                     /pseudo=""
     CDS             4665..>5078
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744612.1"
                     /locus_tag="K6K39_RS36345"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07442"
                     /product="adenylyltransferase/cytidyltransferase family
                     protein"
                     /pseudo=""
                     /sec_met_domain="CTP_transf_like (E-value: 6.5e-17,
                     bitscore: 60.9, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRIGFAPGVYDLFHIGHLNILRQARRHCDRLIAGVTSDDLVERL
                     KGRPPVVPLTERLEIVGSLRCVDLAVVESEEDKLEMWKQIGFHVIFKGDDWRGTPKWES
                     LERRFAEVGVEVVYFPYTMHTSSTLLRGSLELLS"
     gene            complement(5103..5816)
                     /locus_tag="K6K39_RS36350"
                     /old_locus_tag="EASAB2608_07443"
     CDS             complement(5103..5816)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669251.1"
                     /locus_tag="K6K39_RS36350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07443"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_086703812.1"
                     /transl_table=11
                     /translation="MTGFIETLRYMTAAQKPAKGVSVYTLFVNRPAGRVLAALAYRAGA
                     TPNQLTVLGALFTFPALAAVALVRPGPGLAVCVCAALAVGFALDAADGQLARTQRSGSP
                     SGEWLDHVLDCVKLVTVHLVVLVSFYRFFSLPSPAFLLAPMLFELAAVVIFFAGILTEQ
                     LKRRTTAPAAPAAPAESAPALRSVLLLPVDYGVTCLGFLFLGSQHVFLSVYCTLLLAHL
                     VFMAAFLVKWFRELR"
     gene            5917..7416
                     /locus_tag="K6K39_RS36355"
                     /old_locus_tag="EASAB2608_07444"
     CDS             5917..7416
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669250.1"
                     /locus_tag="K6K39_RS36355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07444"
                     /product="glycosyl hydrolase family 28-related protein"
                     /protein_id="WP_221335367.1"
                     /transl_table=11
                     /translation="MSRVSRRHLLRGGASVLAGAALPGRSALAAARSSDKPETVVNVAD
                     LGAVGDGRTDDSGAFEIAYAFAAARVSDGVGRVVIEIPAGEFLITRPHALLNGVAPPRP
                     ASGLRFSGAGRRMTSLVFRPGTGPNSYLCRNQDVWSNLSFERMQFRSATPGASFFDSYS
                     TGQAQDYRFSECEWMGEWEYGLALSGTDTNSEMRWEACRVGGRYRRAFLYSGLTRAGQQ
                     EPNDQDQFLNYWFTDMKVEYEWGNFLEFPYGGSIACRGGSYIITDRRPQSTPEYGTTST
                     FFRFPVNRHHDSVQRFHAQDIRFEVRNPDVVVIDCVWDSGTVHFSDCDDTAFAHKDFSA
                     EVRPHRYTVGPRGPLIRYDSCQLVGRHTYRPASADPLPVVARYDMCLLRSHAARDFAVT
                     SGTSRAPFVQFVHCIDAGTPSGASGPASPATPPPPPCLAPSPSPSPAPATAPEPSPAAA
                     PEPRPATTPAPGPAATPGATDAPTPRDAGHTDCASPQQKPP"
     misc_feature    7642..7651
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     gene            7762..8883
                     /locus_tag="K6K39_RS36360"
                     /old_locus_tag="EASAB2608_07445"
     CDS             7762..8883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433956.1"
                     /locus_tag="K6K39_RS36360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07445"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_223283977.1"
                     /transl_table=11
                     /translation="MSRLAHSALHRVRPGMAALTAVTAVMAVGVSGQPATADDAPAVPR
                     AAGAPSGISTLTKQLTTPWGISFLRGHKAALVTERDTADVWKVALDGAKKKVGTVPEAV
                     WSEETQDKGGLLGVAVSPTWNGTTDQDVFFMETTREDNRVVKMRFDGNKLSGYDPILTG
                     ITRDSQHNGGKIAFGPDGYLYVTTGDAQKRQLAQDKKSLNGKILRITKSGAAAPGNPFG
                     TRVYSYGHRNPQGLAWDRAGHLWSTEIGAEKWDELNLVKPGRNYGWPTCEGTCNAAGTT
                     NPKMVWDPDEGGVPAQVAVVDNVLYATTLSGRRLWRMPIDSTGEDVGPATAYYNGAYGR
                     LRALAKVPGADQLWVGTSDRGNDKDLLLKVTIK"
     gene            8941..9081
                     /gene="pqqA"
                     /locus_tag="K6K39_RS36365"
                     /old_locus_tag="EASAB2608_07446"
     CDS             8941..9081
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094221484.1"
                     /locus_tag="K6K39_RS36365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07446"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_059247681.1"
                     /transl_table=11
                     /translation="MNEAVEQIEQPARATAEETAPTAWQTPGYAIVDTALEVTAYSLSV
                     R"
     gene            9090..10004
                     /gene="pqqB"
                     /locus_tag="K6K39_RS36370"
                     /old_locus_tag="EASAB2608_07447"
     CDS             9090..10004
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="K6K39_RS36370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07447"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_221335368.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGIPQWNCACPGCSGARAHPGRRRRHASLAVRTD
                     EGRWYLVNATPDIGDQIETHPVLHPGPGPRQTPIAGVVLTDAELDHTLGIWRLREADGL
                     EILATAPVRQAVDGRLGLGAVLTPYTTLTWRDLEHRRTQPLGADASGPAGSGVRISAVP
                     VSGKRPRYAADAPEDDAWVVALRLYDPVTGRTALYAPAVAAWSDALHRAAAEADCVIVD
                     GTFWDEEEPRRTGISARTATGMGHLPIDGPAGTARILATLSARCLYTHLNNTNPLVDPA
                     APQHKRLARLGLEVADDGMVIEL"
     gene            10001..10765
                     /gene="pqqC"
                     /locus_tag="K6K39_RS36375"
                     /old_locus_tag="EASAB2608_07448"
     CDS             10001..10765
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669246.1"
                     /locus_tag="K6K39_RS36375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07448"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_221335369.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.8e-87, bitscore:
                     290.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTLAPPAKPWSPAEFEARLRAVGQDRYHDRHPFNLRMHQGDLT
                     PDEVRCWITNRFHYQRHIPVKDALILAKLDSSRLRRMWLRRIEDHDGRDEGEGGIERWL
                     RLGEAAGLDRRTLLSGESVLPGVRLAVEGYVNFCRLRSPLEAVAASLTELTAPDLMRLR
                     IEAFERHYPWIAADGLGYFRTRVDQGRRDSAEALDLVLRWASSREEQESAVAALSFKCE
                     VLWALLDAVQHHAVRQRTVPQRAGHDGPRERV"
     gene            10813..11034
                     /gene="pqqD"
                     /locus_tag="K6K39_RS36380"
                     /old_locus_tag="EASAB2608_07449"
     CDS             10813..11034
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669245.1"
                     /locus_tag="K6K39_RS36380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07449"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_399010835.1"
                     /sec_met_domain="PqqD_RRE (E-value: 4.6e-14, bitscore:
                     50.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.8e-08, bitscore: 32.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRHDAVRGTDLLVLPERVVVLKGHAGMVVGLCDGTRTVPGIVGE
                     LAERFPGAPVADSVPAFLDSMRQEGWLT"
     aSDomain        10816..11031
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K6K39_RS36380_PqqD_RRE.1"
                     /evalue="1.60E-16"
                     /identifier="RREFam006.1"
                     /label="K6K39_RS36380"
                     /locus_tag="K6K39_RS36380"
                     /protein_end="73"
                     /protein_start="1"
                     /score="50.8"
                     /tool="antismash"
                     /translation="LRHDAVRGTDLLVLPERVVVLKGHAGMVVGLCDGTRTVPGIVGEL
                     AERFPGAPVADSVPAFLDSMRQEGWLT"
     gene            11031..12194
                     /gene="pqqE"
                     /locus_tag="K6K39_RS36385"
                     /old_locus_tag="EASAB2608_07450"
     CDS             11031..12194
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669244.1"
                     /locus_tag="K6K39_RS36385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07450"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_059247678.1"
                     /sec_met_domain="PF04055 (E-value: 1.7e-24, bitscore: 85.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.3e-05, bitscore: 24.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-05, bitscore: 24.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.6e-07, bitscore:
                     28.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPANPGAAARPAPPWALLAELTHACPLHCPYCSNPLELARRSA
                     ELSTDEWTDVLRQAGDLGVVHTHLSGGEPLLRPDLERIVAAAEAAGIYTQLVTSGTGLD
                     EARLAALTAAGLRSVQLSVQHADPRAGDRIAGRPSSFAAKERAAALVRRAGLPLGLNVV
                     LHRDNLDAVDALIDLGVAWGADRVELANTQFYGWGLLNRAALLPTRDQLARARETVERR
                     REQLAGRIDLVWVVPDYFDGVAKPCMGGWGAVSLTVAPDGTVLPCPAAASLPDLHPPTV
                     RERPLAWIWEHSAAFNRFRGTDWMTGPCGGCPRREEDFGGCRCQAFALTGDAARTDPAC
                     ALSPDHHLVREPADAGRPEPPPYVYRRPGAVPAPAAGPAPSVVATDG"
     gene            complement(12285..13895)
                     /locus_tag="K6K39_RS36390"
                     /old_locus_tag="EASAB2608_07451"
     CDS             complement(12285..13895)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008737083.1"
                     /locus_tag="K6K39_RS36390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07451"
                     /product="TROVE domain-containing protein"
                     /protein_id="WP_221335371.1"
                     /transl_table=11
                     /translation="MLVAPHISAAARAVPPPRPRHRPASPQLRTHEGGPAFVREPREEL
                     FLLAVGNFVSQETFYESGEERDDRYTRLVGELAVQDPAWTAGLLRWLRGEGNMRTASLV
                     GAAAYVRARLAAGATGGPANRSVIDSVLQRADEPGELLAHWVSAYGRKVPQPVKRGIAD
                     AVRRLYTSRSLLKYDTPTKNFRFGDVLNLVHASPDPDKPWQGALFQYALDRRYHPERAV
                     PPPSDRLLTAHRALMESAPHERRAMVTGPGGSERLAAAGMTWESLAGWLHGPMDAAVWE
                     AVIPTMGPMALLRNLRNFDEAGISDEVAARVAARLSDATEVARSRQFPFRYLAAHRHAP
                     SQRWAVALERALAHSLANVPALPGRTLILVDRSDSMFWDTLSERSKLTRADAAAVFGTA
                     LAMRAEQADLVEFGWRSAVVPFEPGEPVLDVLKRFHSLGGTHTTKAVRTHYREHDRVLI
                     VTDEQAAPDAPGAVPEPVPADIPVYTWNLAGYRPAHGPTGPHRHTFGGLADAAFRMVGL
                     IEAGREAAWPWTEAPPDAS"
     gene            complement(14248..14652)
                     /locus_tag="K6K39_RS36395"
                     /old_locus_tag="EASAB2608_07452"
     CDS             complement(14248..14652)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000742.1"
                     /locus_tag="K6K39_RS36395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07452"
                     /product="DUF3291 domain-containing protein"
                     /protein_id="WP_260335960.1"
                     /transl_table=11
                     /translation="MADFVAQQPEINALADRSPGFVWRMVDDGGADATGLRPDGNDALL
                     LINCSVWESVEALRNFTYHSDHLRVLSRRREWFRRMAEAHQAMWWIPAGHRPTVAEAME
                     RVALLREHGPGPEAFTFRDPYPAPAPAVRL"
     misc_feature    14637..14651
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(14691..14704)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    14748..14763
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            complement(14752..15390)
                     /locus_tag="K6K39_RS36400"
                     /old_locus_tag="EASAB2608_07453"
     CDS             complement(14752..15390)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134142.1"
                     /locus_tag="K6K39_RS36400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07453"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_221335372.1"
                     /transl_table=11
                     /translation="MTDEDSTFDVLGLLSDPVRRRLYRCVAAAPEEVSRDAAAEAAGVS
                     RSLAAFHLDKLVEAGLLAVSFRRLSGRTGPGAGRPAKLYRRAEGEHAVSVPPRSYDTAG
                     RLLAEVLEDAGLDRELQAAARAAGAAQPDARTDDVVAALRARGYQPFRDGETLRLRNCP
                     FHALATEFPALICGMNLALIEGLVPEPWSAAMDPCPGGCCVALSKKKND"
     gene            15630..16157
                     /locus_tag="K6K39_RS36405"
                     /old_locus_tag="EASAB2608_07454"
     CDS             15630..16157
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS36405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_07454"
                     /product="hypothetical protein"
                     /protein_id="WP_143650193.1"
                     /transl_table=11
                     /translation="MAMVGLFWIAEGDVYVGAKPAGLAPGVRLTPEGVVGLGDGQSSLC
                     LWEDVSTLTVADVPVKSLMRRVGAVTDLALGTVKELALPGGSVWADEAPAMMTVRVGSA
                     DGERELGAYVAAAVGYPQTEIDLSRALLSRLTEGAATMATTLAAMSEWGRAWEGGSPRG
                     AERERLLRSWVG"
     misc_feature    complement(16485..16505)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     misc_feature    16794..16808
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    complement(16796..16807)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.34"
                     /tool="antismash"
     gene            16880..17254
                     /locus_tag="K6K39_RS36410"
                     /old_locus_tag="EASAB2608_07456"
     CDS             16880..17254
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938756.1"
                     /locus_tag="K6K39_RS36410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07456"
                     /product="beta/gamma crystallin domain-containing protein"
                     /protein_id="WP_260335961.1"
                     /transl_table=11
                     /translation="MRRSLGVAAVAAAALAATVVPAAAATASPTTASAIGPTINRTDCN
                     ENSYLEIHNNEGRDTLCFANAGTMPVAIYGVNWVESGNNVVTLQFQRNLSDPRLETITL
                     QKWSSWNPGHIHQIISIRIH"
     gene            complement(17467..17865)
                     /locus_tag="K6K39_RS36415"
                     /old_locus_tag="EASAB2608_07457"
     CDS             complement(17467..17865)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS36415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_07457"
                     /product="hypothetical protein"
                     /protein_id="WP_086702572.1"
                     /transl_table=11
                     /translation="MALFRRGDGHHRGDDHDNRWTDENGWTTDRMSDGTIFRWRVRMER
                     IGDILPEYKEALEAVAREEGYTYREYVAWAANLTDARMNDTRDRIRNGLAGPREAALYR
                     CWLGARLAVHEVQYRLEVRPGKFIWSGR"
     gene            complement(17929..19032)
                     /locus_tag="K6K39_RS36420"
                     /old_locus_tag="EASAB2608_07458"
     CDS             complement(17929..19032)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS36420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_07458"
                     /product="serine protease"
                     /protein_id="WP_221335374.1"
                     /transl_table=11
                     /translation="MPSRHALTAVLGLLALTAALLTAAPPARAAVPAFELRPLVPAGPD
                     HQERLRAEVEYWTLGKMADAGLNNEDRDATAPPGGWDDLSRPWPREHGRISRTAGKIFM
                     EYTDVETGATSTSSCSGNVVSSANRSVVLTAAHCLRIHTPLDVGFGNVVATNMVFVPGF
                     DGANLPRDTSSTRLPGKDIAPYGVWGVTRQWITHTWSRSADWLLGRDMAAVVVANPDDP
                     RPIAEVTGGQEVAFGQPQNQTHHVFGYPTINERNHYRPGNVPAALQRTFDGRSLMVTQG
                     TTHNDPVYYNDVLAGAQSPGCSGGALLQNFDPATGAGVQVGVFSRYDDPAQIIGILGWV
                     QGPNMSSTHFGAEEQAVYNAAQAASPA"
     gene            complement(19164..20006)
                     /locus_tag="K6K39_RS36425"
                     /old_locus_tag="EASAB2608_07459"
     CDS             complement(19164..20006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081356.1"
                     /locus_tag="K6K39_RS36425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07459"
                     /product="hypothetical protein"
                     /protein_id="WP_094374764.1"
                     /transl_table=11
                     /translation="MIRRWCVLVLSLTVLWTVAAGAARAETGKRVHNGMQILFSPSTPS
                     AFCTIGAVGNDKYGHRIAISAGHCLNDPDGTYADREIPDDVAPVYDRADPAFGPIGHVR
                     YFKDPEGSQTGHMTKDYMIIELVPQVTLSSQGPYLKQTGEVRVPGGTASPNALRPALDS
                     ERLLATGNEELIVAGQTGVWFGTIMDTTGGIYRSPAAHLPGDSGGPAVRHVPGSELPSQ
                     ENGFQAEGPWAGITKAITLSLPPFEYTSSANILADLRARDAVTPGGVYGAGFEVTGNP"
     gene            complement(20047..21141)
                     /locus_tag="K6K39_RS36430"
                     /old_locus_tag="EASAB2608_07460"
     CDS             complement(20047..21141)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509825.1"
                     /locus_tag="K6K39_RS36430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_07460"
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_221335375.1"
                     /sec_met_domain="PF00561 (E-value: 0.00011, bitscore: 20.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSALPTRLTRATAAALALAAALLLPGTPSAHAEGPGARPPEMTD
                     GFGLTQVGTATGSATNFVVTVTTPEVDGEHRVRILLPADYADRPDKRYPVLYFLHGASD
                     DPGNPNVAYPALTAAQSMITVIPDGGRRGWYTNWLDQGTAAGAQNWENFHISQVIPFID
                     TNLRTVSARRARAVAGLSMGGFGALHYAQRHPGLFSQVASLSGANELSLRHAVMRAAVV
                     ATLTNIGAPLCGSSNPTCSLDFGPAVSSDAVFGTPYPVFGADWRWDEADPVAHMDVLAR
                     AGTGVTLYTGNGQGNPAEPEFWVRSASQHAKERLDQLGHPSHYVDYGDGSGWGDDCDGS
                     HTSGCWAQDLVDFVPRLEAAFASS"
     misc_feature    21301..21315
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     misc_feature    21620..21633
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.71"
                     /tool="antismash"
     misc_feature    complement(21620..21634)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
ORIGIN
        1 agccgtcatc gccctgggga tcgtcctggg actgctgggc ggggccgcac tggcgttctc
       61 ccgcgcccac acctacacct ccaccagcga agtcctcgta cgctccaccg ccgacccctt
      121 cggcacggtc agcgtggccg ccgacaacca ggtcagcatg ggcaccgagc agcagatcgc
      181 cgccagcgcc gcggtcgccg tccgcgcggc ccgcctcatg ggccgggccg acgccacggc
      241 ggccacgctc ggcaaggacc tgcggatcac caaccgggcg aagtcgcagg tgctgcgctt
      301 cgagttcacc gcccggaccc cggggcgcgc ggcgcgcggc gccaacgcct tcgccgaggc
      361 ctacctggcc gaccgcaagg cccggaacga agccgccgta cagcgggccg gccgcagcgt
      421 gcagcagcag atcaaggcgg tgcaggcggc caaggagaag gacgaggacg aggccgtcga
      481 caaggccgtg cagagcgagc tggacaccct gcacaagcgc atcgtcgaga tcaactcccg
      541 cgacaccgtc ggaggcgaca tcgtccgccg cggcgaggca cccgccaggc cctcggggcc
      601 cggctgggcc gtcctgctca ccctggggct ggcgagcgga ctggccctcg gcgtcctgct
      661 ggcctggctg cgctccgccc tcgacagccg ggtccggtcg gccgacgagg cccgggccgc
      721 gctgcgcgcg ccggtgctcg gcctgctgcc gcccgagccc gacgaggacg cccccctgct
      781 gacggtcggt caccagggcg gcgaccgcgc ggagacctgc cgcgccctgg cctaccgcct
      841 gcgccgcacc ggcctgcccg ccggcgccgg ccgggtcctc gtcgtgtccc cccggcgcgg
      901 cgccgccacc gaggaggtcg ccgtcaacct ggccgcggcc ttcgcggagt gcggggacga
      961 ggtgttgctg gtggacgccg accccggcac gcccgccctc accacccggc tgcccctgct
     1021 gccggacgac gcccgcacgc ccgaggaggc ctccctgccg gaggggagcc gcctcgtcga
     1081 cgccggtgcc gccgggcggt tcgcctgctg cgccggcggc ggcaccggcg ggcccgccca
     1141 gccgggcggg tccgccgccg tccaccggct gctgcccgga cccgactccc gcgccgctgt
     1201 cgtcgtcacc cggccgctcc tggagcacgc cgacgcactc gcggtcgccc agcgcgtcga
     1261 cggcgtcctg ttggtcgccg gcctcgacac cacccggcgg gacgacctca agcgggcgca
     1321 cgagctgatc gactgctccg gcgcgaccct cctcggcgcc gtgctcgacg ccggccgccg
     1381 gaggggtcgt ctccgcgccc tcctgcgccg ccgccccgga cgccgcccgg aggcggagcc
     1441 cgtcacgccg gtcgtggaac tgcccgcgca ggacgagacg ctcacggtct cccgcgggtg
     1501 accgccccgg aagcgaccgc ccccgggtcc gccgccccga gcgtcgccgc cgccgcccgc
     1561 ggcggctggt ggggggtggc gggcgccgcg gtcaacgccg tcttcgcctt cgtcttcgtc
     1621 ggcctgatca cccgcgccgt cggagcgcag ggggccggag cggtcttcac cggggtggcc
     1681 gtgttcacca tcctcagcaa cacctgcaag ctcggtgccg acaccgggct ggtccggttc
     1741 gtctcccgcg acatcgccgt gggcggcggc cggtcggtcg gcgctctgct gcgcgcggcc
     1801 gtcgtacccg cggctgtggc cagtacggtg gccgccctgc cgctgctgct gtgccccgcg
     1861 gtggccacca cgctcctgcc gcacctgccg ccgtccgacg ccgtcaccct cgtccggctc
     1921 ttcgggctgt tcctgcccgt cgccaccgtc ggactggtcc tgctcggcgc cactcagggc
     1981 cacggcaccg tgctgccgtt cgtcggcgtg gagcagatcg gcaaacccgt gctgcgggtg
     2041 gccgtcgccg tcccggtggc ctgcttcgcg cccggcctgc tcgccctggc cgcggcctgg
     2101 ctgctgcccg cactggccgg caccgtggtc gcctggctgg ccctgcgccg ctgccgcgcc
     2161 gcccgcggca ccgcgcgtcc ggccccgcgc ggagccgttc cctggcgcgg cttctggagc
     2221 ttcgcggcac cccgcgcgat ctcgtccgtg ttcgacttca gcgcggtctg gatcggcgtc
     2281 gtcctgctgt ccgcgctggc caccggcgcc gaggcgggcg tctacaccgc catcggccgc
     2341 gtcgtcaccg cgggcaccct gctgcaactg gccatccggc tcgccgtggc accccagatc
     2401 agccggctgc tcgccgtcga ccaggtcgcc gaggcgcgcc agctgcaccg cgtctcgacc
     2461 tgctgggtcg tgctcttctc ctggccgctg ttcgtcctcc tcgccggctt cccgcggacc
     2521 gtcctgtcgg tcttcggccc ggagttcgtc cagggcgcgc ccgccctggt cgtgctgtgc
     2581 ggggccgcca tggtcaacgt cgcggtcggc aacgcccaga ccgtgctcct gatgtccggc
     2641 cgcagctcct ggcatctggc cgtcaccgcc gcggcgttcg cggtccagct gacggtcggg
     2701 ctgctcacgg tgccgaagtg gggcgtcctc ggtgccgccg tgtcctgggg cgcggccatc
     2761 gtcgtggaga acctttcggc cgccctgctc atccggctgc gcctcggctt caccaccgtg
     2821 gaccgcggct acacgaccgc cctcggtgcc gcactggccg tggcgacggt gctgggcgcc
     2881 gtccgcgtcc tgggaggtga cacgctgtca ggactcgccg ccgggatgac gttgggaatg
     2941 tgtgtatttg gtactagttt gtggtggtat cgcaggccgc tgggagtgaa tgagctggtc
     3001 ggagttctgc gccgtcgcgc cgcgtgagcc caggcagggg cgtacggccc gggttcggca
     3061 ggccccgtgt cattccccgc gtgtcgccca caccactgtc atccggggtg tccattgcgc
     3121 ctgagaaagc tcccgtcgag ggcggccacc agggctgtcg ccgccaccgt cctgtgctcc
     3181 gccgccctgc tccatcccgc gctcgccacg gccgacgacg gtccccggcc ggcgttcacc
     3241 gccgacccgc tgaccacatg gcagacgaac ggcatcgtct ggtcgctggc cgccgcgcac
     3301 ggtgtcgtct acgtcggcgg gaccttcgac tcggtacggc cgtcgggcgc ggaacccggc
     3361 gaccgcgagg taccgcgccg caacttcgcc gcgttcgacg cggtgaccgg cgccctgctg
     3421 ccgtgcgcgc cgtcgttcac cggaggcgag ggaaccgtcc gtgcgctcaa gacctcgccg
     3481 gacggccggg tgctgtacgt gggcggttcc ttcagccggg tcggatccac cggcgtggcc
     3541 agcgccgtcg ccctgaacac ggccgactgc tccctgcggc gggacttccg gccggcggtg
     3601 tcggcgaccg tccgggccat cgacaccacg gaccggcggg tctatctcgg cggtgacttc
     3661 cgccgggtcg acggccggac cagacagcac gtcgccgcct tcacccccca aggcacgctg
     3721 ctggacttcc gggcgcgcgt cgacgccccg gtgcgcgcgc tgtcggcggt tccctcgcgc
     3781 caaaggatct acgtcggcgg cgacttcgag acggtcaacg accggtgggc ccacgcgctg
     3841 gtcgccctgg acgccaccag cggcgcgacc gtgcgctcct tcccggactg gctgccgccc
     3901 gggtcggtgg tgaagtcgat cgcacaggac gacacccgct tctacgtggc ggccgaaggc
     3961 cacggcgagg gcatcttcga cggccgtatc gcgggccgtc tcgacgacca ccgcatggtg
     4021 tggaaggacg actgccacgg tgccacccag gccgtgctgc cctatcaggg cgtcctctac
     4081 agtgcctcgc acgcacacga ctgcgccggg acaccgggcg gcttccccga gcggcaggac
     4141 cggcagcacc tgctggccca gtcgcctcgc gaccgcagga tcctgcactg gttccccgac
     4201 accgacgagg gcagggggga gcgggtggga ccccgtgcgc tggcggtcgc ccggggcatc
     4261 ctctgggtgg gcggcgagtt cacccgggtc aacggcgcgc cccagcaggg cctcacccgc
     4321 ttcgggaccg gccccgacac cggggcgccg gcggttcccg ccctctccct ctcggccgcg
     4381 gaacccggac acgtcaccct ccgctggaag gcctcgtggg accgggacga cgcggcgctc
     4441 acctatcgcc tctaccggga cggccggctc gtctcccggc aggagcggtc gtccacctac
     4501 tggaaccgcc cgtggatgag ctacaccgac tccgtggacg ccggcacccg ccaccagtac
     4561 cggatcgagg tcacggacgg cgtgaacacc tcgccgaagt ccccgccgtt gcgggtggcc
     4621 gtgcccgggg ggacgacggc atggacggcg ggtgagtcgg ccaaatgacc cgcatcggat
     4681 tcgcgcccgg cgtctacgac ctgttccaca tcgggcacct caacatcctg cgccaggcgc
     4741 gccggcactg tgaccgcctc atcgcgggcg tcacctcgga cgacctggtc gagcgcctca
     4801 agggcagacc gccggtcgtc ccgctcaccg agcgcctgga gatcgtcggc agcctgcgct
     4861 gcgtcgacct ggccgtcgtc gagtcggagg aggacaagct ggagatgtgg aagcagatcg
     4921 gcttccacgt catcttcaag ggcgacgact ggcggggaac gcccaagtgg gagtcgctgg
     4981 agcggcgttt cgccgaggtc ggcgtcgagg tcgtctactt cccctacacg atgcacacct
     5041 ccagcaccct gctgcggggt tccctggaac tgctctcccg gcccgagcgg ctggagatcc
     5101 tctcagcgca gctcccggaa ccacttgacc aggaaggcgg ccatgaacac gaggtgggcc
     5161 agcagcaatg tgcagtagac ggaaaggaag acgtgctgac tgcccaggaa taggaagccg
     5221 aggcaggtca cgccgtagtc gaccggaagg agcagcacgg accgcagcgc cggggcggat
     5281 tccgccggtg ccgccggtgc cgccggtgcc gtggtgcgcc gcttgagctg ctccgtcagg
     5341 atccccgcga agaagatcac cacggccgcc agttcgaaca gcatcggtgc gagcaggaag
     5401 gcggggctgg gcagtgagaa gaaacggtag aacgacacca gcacgaccag gtgcaccgtg
     5461 acgagcttga cgcagtccag cacgtggtcc agccactcgc cggacggact tcccgagcgc
     5521 tgggtgcggg cgagctgacc gtccgccgcg tcgagggcga accccacagc cagcgccgca
     5581 cagacgcaga ccgcaagccc cggaccgggc cgcaccaagg ccacggcggc cagggcgggg
     5641 aaggtgaaga gcgcgccgag cacggtcagc tgattggggg tcgccccggc gcggtaggcc
     5701 aacgcggcca ggacacggcc cgccggacgg ttgacgaaca gggtgtagac cgacacaccc
     5761 ttcgcgggct tctgcgccgc cgtcatgtac ctgagcgtct cgatgaaccc ggtcatttcc
     5821 ctccttgatg aggaaagcgg tggaaagcgc tgcaaagcgc cttaaagcgc tggaaacgct
     5881 ggaaagaagg cgattatgcc agaatggggt ggatcggtgt cccgtgtcag ccgtcggcat
     5941 ctcctgcgtg gcggcgcctc ggtgctggcc ggggcggccc tgcccggccg cagcgcgctc
     6001 gccgccgcgc gctcctcgga caagccggag accgtggtca acgtggccga cctgggggcg
     6061 gtgggcgacg ggcggaccga cgacagcgga gccttcgaga tcgcctacgc gttcgccgcc
     6121 gcccgcgtct ccgacggggt cggccgcgtg gtgatcgaga ttcccgccgg agagttcctc
     6181 atcacccgcc cgcacgccct gctgaacggt gtcgccccgc cgcggcccgc gagcggcctg
     6241 cggttctccg gcgcgggcag gcgcatgacc agcctcgtgt tccgccccgg caccggcccg
     6301 aactcctatc tgtgccggaa ccaggacgtg tggtcgaacc tctccttcga acgcatgcag
     6361 ttccgctcgg ccacaccggg cgcctccttc ttcgactcgt actcgaccgg gcaggcgcag
     6421 gactaccggt tctccgagtg cgagtggatg ggggagtggg agtacgggct cgccctgagc
     6481 ggcacggaca ccaactcgga gatgcggtgg gaggcgtgcc gggtcggcgg ccggtaccgc
     6541 agggcgttcc tgtactcggg gctgacccgg gcgggacagc aggagccgaa cgaccaggac
     6601 cagttcctca actactggtt caccgacatg aaggtcgagt acgagtgggg gaacttcctg
     6661 gagttcccct acggcggttc catcgcctgc cggggcggct cgtacatcat caccgacagg
     6721 cgtccgcaga gcacgccgga gtacggcacc accagcacct tcttccgttt ccccgtcaac
     6781 cggcaccacg actccgtgca gcggttccac gcccaggaca tccgcttcga ggtgcgcaac
     6841 cccgacgtgg tcgtcatcga ctgcgtctgg gacagcggca cggtccactt cagcgactgc
     6901 gacgacaccg ccttcgccca caaggacttc tccgccgaag tccgcccgca ccgctacacc
     6961 gtgggcccgc gcgggccgct gatccgctac gactcctgcc agctggtggg ccgccacacg
     7021 taccggccgg cctccgcgga cccgctcccg gtcgtcgccc gctacgacat gtgcctgctc
     7081 cgcagtcatg cggcacgcga cttcgcggtc acctccggaa cgagccgggc ccccttcgtc
     7141 cagttcgtcc actgcatcga cgccggcacc ccgagcggcg cgtccggacc ggcctccccc
     7201 gccacaccgc ccccgccgcc gtgcctcgcg cccagcccgt ccccgagtcc ggcccccgcc
     7261 acggcacccg agccgagccc cgccgccgca cccgaaccgc gcccggcgac gacccccgcg
     7321 cccggacccg cggcgactcc cggggccacg gacgctccga cgccgcgcga cgccggtcac
     7381 accgactgcg cctccccgca gcagaagccg ccctgacccc gcgtactccg tccgcgccct
     7441 cccgcaccac ggcggtcact cgtgggaggg acttcccggt gtcggcgggc cggtcgcggc
     7501 cgggtcggcc cgcaagctcg cagacatgcg cagtcccgac gccgggagac ggtccgtcag
     7561 caggatgggc ggatcccggt ggccaatgct tcaaggggcg ctcgatactc cagaaaggag
     7621 tcattgccac gcttcggccc acgttttttc accggggcca ccacgatgcg gcgcagcaat
     7681 gagcaccccc tcgtatcgca gtcggccgcg tcgtttccgt cgttgaatca cgcggtcgcg
     7741 ccacgacagg aaaggcttca gatgtcacgt ttggcgcatt cggcgctgca tcgggtccgc
     7801 ccgggcatgg ccgcgctcac cgctgtcacc gccgtcatgg ccgtcggcgt gtccgggcag
     7861 cccgcgacgg cggatgatgc acccgccgtc ccccgtgcgg ccggtgcgcc gtcgggcatc
     7921 agcaccctca ccaagcaatt gacgacccct tgggggatct cgttcctccg cggccacaag
     7981 gcggcgctgg tgacggaacg cgacaccgcc gacgtctgga aggtcgccct ggacggcgcg
     8041 aagaagaagg tcggcacggt gcccgaggcg gtgtggagcg aggagaccca ggacaagggc
     8101 gggctgctgg gcgtcgccgt gtcaccgacc tggaacggca cgaccgacca ggacgtgttc
     8161 ttcatggaga ccacgcgtga ggacaaccgt gtggtcaaga tgcgcttcga cggcaacaag
     8221 ctgagcggct acgaccccat cctgaccgga atcacgaggg acagccagca caacggcgga
     8281 aagattgcgt tcgggcccga cggatatctg tacgtcacca ccggcgacgc ccagaagcgc
     8341 cagctcgccc aggacaagaa gtcgctcaac ggaaagatcc tgcggatcac caagagcggt
     8401 gccgcggctc ccggcaaccc gttcggaaca cgcgtctaca gctacggcca ccgcaatccc
     8461 caggggctgg cctgggaccg cgccgggcat ttgtggtcca ccgagatcgg cgcggagaag
     8521 tgggacgaac tcaacctcgt caaaccgggc cggaattacg gctggccgac ctgcgagggc
     8581 acctgcaacg ccgccggaac gacgaatccg aagatggtct gggaccccga cgagggaggc
     8641 gtgcccgccc aggtcgcggt cgtcgacaac gtcctctacg ccaccacgct gagcggccgg
     8701 cggctgtggc ggatgccgat cgactccacc ggcgaggacg tcggacccgc gacggcctac
     8761 tacaacggcg cctacggccg gctccgggcg ctggccaagg tccccggcgc cgaccagctc
     8821 tgggtgggca cgagcgaccg aggcaacgac aaggacctcc tcctcaaagt gaccatcaag
     8881 tgaaggcccc ctcccgcacc gggaggtgaa caccccctcg ccgaaaggaa ggcacgcacc
     8941 atgaacgaag ccgtcgagca gatcgagcag cccgcccggg ccaccgccga ggagaccgcc
     9001 ccgaccgcct ggcagacgcc ggggtacgcg atcgtggaca ccgcgctgga ggtcaccgcc
     9061 tactccctca gcgtccgcta acccccgcca tgctgctgca ggtgctcggc accgcggccg
     9121 gcggcggcat cccccagtgg aactgcgcgt gccccgggtg ctccggggca cgcgcccacc
     9181 ccgggcggcg ccgccggcac gcctcgctgg ccgtccgtac cgacgagggc cgctggtacc
     9241 tcgtcaacgc cacccccgac atcggcgacc agatcgaaac ccacccggtc ctccaccccg
     9301 ggcccggccc ccggcagaca ccgatcgccg gagtggttct caccgacgcc gaactcgacc
     9361 acacgctggg catctggcgg ctgcgcgagg ccgacggcct ggagatcctc gccaccgccc
     9421 cggtccgcca ggcggtcgac ggccgcctcg gcctcggcgc ggtcctcacc ccgtacacca
     9481 ccctgacctg gcgggacctg gagcaccggc ggacacagcc gctcggcgcc gacgcgagcg
     9541 gcccggccgg ttccggcgta cggatcagcg ccgtgcccgt ctccggcaag cggccacgct
     9601 acgccgccga cgcacccgag gacgacgcgt gggtcgtcgc gctgcgcctg tacgacccgg
     9661 tcaccggccg gaccgctctg tacgccccgg ccgtcgccgc ctggtcggac gcgctgcacc
     9721 gagccgccgc cgaggccgac tgcgtcatcg tcgacggcac cttctgggac gaggaggagc
     9781 cccgccgcac cggcatctcc gcgcgcaccg cgacgggcat gggccatctg cccatcgacg
     9841 gaccggccgg caccgcacgc atcctcgcca ccctgtccgc ccgctgcctg tacacccacc
     9901 tcaacaacac gaatcccctc gtcgaccccg ccgcgccgca gcacaagcgg ctcgcccggc
     9961 tgggcctcga ggtggccgac gacggaatgg tgatcgagct gtgacgacga cactcgcccc
    10021 gccggcgaag ccgtggagcc ccgccgagtt cgaggcccgg ctgcgcgcgg tgggccagga
    10081 ccggtaccac gaccggcacc ccttcaacct ccgcatgcac cagggcgacc tcaccccgga
    10141 cgaggtgcgc tgctggatca ccaaccgctt ccactaccag cggcacatcc cggtcaagga
    10201 cgcgctgatc ctcgcgaagc tggactcgtc gcggctgcgg cgcatgtggc tgcggcggat
    10261 cgaggaccac gacggacgcg acgagggcga gggcggcatc gagcgctggc tgcggctcgg
    10321 cgaggcggcc ggcctggacc gccggaccct gctgtcgggc gagtccgtac tgccgggcgt
    10381 ccggctggcc gtggaggggt acgtcaactt ctgccggctg cgctcacccc tggaggccgt
    10441 cgccgcctcg ctcaccgagc tgaccgctcc cgatctgatg cgcctgcgca tcgaggcgtt
    10501 cgagcgccac tatccctgga tcgcggcgga cgggctcggc tacttccgca cccgcgtcga
    10561 ccagggccgg cgcgacagcg ccgaggcgct ggacctcgta ctgcggtggg ccagcagccg
    10621 cgaggagcag gagagcgccg tggccgcgct ctccttcaag tgcgaggtgc tgtgggccct
    10681 gctcgacgcc gtgcaacatc acgccgtgcg gcagcgcacc gtaccgcagc gcgccgggca
    10741 tgacggcccg cgggagcggg tgtgacggcg cggtccgccg accagtggtg cccggcgctc
    10801 gcccccgcgc tgatgctgcg gcacgacgcc gtgcgcggca cggacctgct ggtcctgccg
    10861 gaacgcgtgg tcgtcctcaa agggcacgcc ggcatggtcg tcggcctgtg cgacggcacc
    10921 cgtaccgtgc ccggcatcgt cggcgagctg gccgagcgct tcccgggcgc gccggtggcc
    10981 gacagcgtcc ccgccttcct cgacagcatg cggcaggagg gctggctgac atgaccgccc
    11041 ccgcgaaccc cggtgccgcc gcacggcccg cacccccgtg ggccctgctc gccgaactca
    11101 cccacgcctg cccgctgcac tgcccgtact gctcgaaccc gctggaactg gcccgccgct
    11161 ccgccgagct gagcaccgac gagtggacgg acgtcctgcg ccaggccggt gacctgggcg
    11221 tcgtacacac ccatctctcc ggcggcgagc cgctgctgcg ccccgacctg gagcggatcg
    11281 tcgccgccgc cgaggccgcc gggatctaca cacagctggt cacgagcggc accggcctgg
    11341 acgaggcccg gctggccgcg ctcaccgcgg cggggctgcg cagcgtccag ctgtccgtcc
    11401 agcacgccga cccgcgggcc ggcgaccgca tcgccggacg cccctcctcc ttcgccgcca
    11461 aggaacgggc cgcggcgctc gtccgccggg ccgggctgcc gctcggtctg aacgtcgtgc
    11521 tgcaccgcga caacctcgac gccgtggacg cgctgatcga cctgggcgtg gcctggggcg
    11581 cggaccgcgt cgagctggcg aacacgcagt tctacggctg gggactgctc aaccgggccg
    11641 cgctgctgcc gacccgcgac cagttggccc gcgcgcggga gacggtggag cgccggcggg
    11701 agcagctcgc cggccggatc gacctggtgt gggtcgtccc cgactacttc gacggcgtgg
    11761 ccaagccgtg catgggcggc tggggagcgg tctcgctcac cgtcgcgccg gacggcaccg
    11821 tcctgccgtg cccggcggcg gcctcgctgc cggacctgca cccgcccacc gtgcgcgagc
    11881 gtccgctcgc ctggatctgg gagcactccg cggccttcaa ccgcttccgc ggcaccgact
    11941 ggatgacggg cccctgcggc ggctgccccc gccgggagga ggacttcggc ggctgccgct
    12001 gccaggcgtt cgcgctcacc ggcgacgccg cccgcaccga tccggcctgc gcgctctcgc
    12061 ccgaccacca cctcgtccgc gagccggccg acgcgggccg tcccgagccg ccgccgtacg
    12121 tctaccgccg tcccggggcg gtaccggcac cggcagcggg accggccccc tccgtcgtcg
    12181 cgacggacgg ctgaccggcc ccggcccgcc tgcgcagccc ggggccgtcc tgtacggggt
    12241 cccctaccag cgaccggcgg ttcgcgtgtg cccccggcgc gggcctagct cgcgtcgggg
    12301 ggtgcctcgg tccacggcca agcggcctcg cggccggcct cgatgaggcc gaccatccgg
    12361 aacgcggcgt ccgcgaggcc gccgaaggtg tgccggtggg ggcccgtggg gccgtgggcg
    12421 ggccggtacc ccgccagatt ccacgtgtag accgggatgt cggccgggac cggctcgggc
    12481 accgcgccgg gagcgtcggg ggcggcctgc tcgtcggtga cgatcaggac ccggtcgtgc
    12541 tcccggtaat gggtccgcac cgccttcgtg gtgtgggtgc cgccgaggct gtggaaccgt
    12601 ttcagcacat cgagcaccgg ctcgcccggc tcgaacggga ccaccgcgct gcgccagccg
    12661 aactccacca ggtccgcctg ctcggcgcgc atggccagtg cggtgccgaa cacggccgcc
    12721 gcgtccgccc gggtcagctt cgaccgttcg gacagggtgt cccagaacat ggagtcggac
    12781 cggtccacca ggatcagcgt ccggccgggc agggccggta cgttggccag ggagtgggcc
    12841 agcgcccgct ccagcgcgac cgcccagcgc tgcgacggcg cgtgccggtg ggcggcgagg
    12901 tagcggaagg ggaactgccg ggaccgggcg acctcggtgg cgtccgacag ccgggcggcc
    12961 acccgggccg cgacctcgtc cgagatcccc gcctcgtcga agttccgcag attccgcagg
    13021 agcgccatcg gccccatcgt ggggatcacg gcttcccaga cggccgcgtc catcggtccg
    13081 tgcagccatc ccgccaggga ctcccacgtc atgcccgcag cggccagccg ttcggagccg
    13141 cccggcccgg tcaccatcgc ccgccgctcg tgcggggcgg actccatcag cgcccggtgg
    13201 gcggtcagca ggcggtcgga cggcggcgga accgctcgct ccgggtggta tcggcggtcc
    13261 agggcgtact ggaagagcgc gccctgccag ggcttgtccg gatcgggaga ggcgtgcacc
    13321 aggttgagca cgtcgccgaa gcggaagttc ttggtcgggg tgtcgtactt gagcagggac
    13381 cgggacgtgt acagccggcg gacggcgtcg gcgatgcccc gcttcacggg ttgcggcacc
    13441 ttccgcccgt acgccgagac ccagtgggcc agcagctcgc cgggctcgtc ggcgcgctgg
    13501 aggaccgagt cgatcacgga ccggttggcc gggccgccgg tcgccccggc cgccagccgg
    13561 gcccgcacgt acgcggcggc gcccaccagg gacgccgtac gcatgttgcc ctcgccgcgc
    13621 agccatcgca gcagccccgc cgtccacgcg gggtcctgga cggcgagttc cccgacgagg
    13681 cgggtgtacc ggtcgtcccg ctcctcgccg ctctcgtaga aggtctcctg cgagacgaag
    13741 ttgcccaccg cgaggaggaa cagctcctcc cggggctccc ggacgaaggc cgggccgccc
    13801 tcgtgggtgc gcagctgcgg tgacgcgggc cggtgccggg gccgtggtgg gggcacggcg
    13861 cgggcggcgg cggagatgtg cggggccacg agcatctcgg gccacatctt ggagacgcgt
    13921 gggctgtgac gaggcagcga atccccccgg attcgaagga cgggaggccc cggtcagaag
    13981 gacggacggg gcgggagcgc ccgcgcctgc cgagatcaaa ggggcggcgg cgtcacttgg
    14041 ttgtcagaag gaagtagccg cagccaggcg catcggaggc gcggtcgcga agccaactta
    14101 caagggccgg caggccgtgc accagcgatt aaacgccggc gatccgccgg cccggtacgg
    14161 gctgcccctg ctcgacggcc cgccgccgga ctcctgtgcg gtgtcctcgc cccggcgcat
    14221 gccggtgacc gctgtttcgt gcggggttca gagccgcacc gccggggccg gggccgggta
    14281 cgggtcgcgg aaggtgaacg cctcgggtcc ggggccgtgt tcgcgcagca gcgcgacccg
    14341 ctccatcgcc tcggcgacgg tggggcggtg gccggccggg atccaccaca tggcctggtg
    14401 cgcctcggcc atgcggcgga accactcccg gcggcggctc agcacgcgca ggtgatcgct
    14461 gtggtacgtg aagttccgca gggcttcgac cgactcccag accgagcagt tgatcagcag
    14521 cagcgcgtcg ttcccgtcgg ggcggaggcc ggtcgcgtcc gcgccgccgt cgtcgaccat
    14581 gcgccagacg aatcccgggc tccggtccgc aagtgcgttg atctccggct gttgggcgac
    14641 gaagtcggcc aacagccggg ctgtccagcg gggcgacgat gcggccgatg ttgacctgcg
    14701 ccaagtgatg ctcagtcatg gagcaagcat ggcccggccc gtcttctata gtcaatcatt
    14761 tttcttttta gaaagggcga cgcagcagcc gccggggcac gggtccatcg ccgcggacca
    14821 cggctcgggc accagcccct cgatgagcgc caggttcatc ccgcagatca gggcggggaa
    14881 ctccgtcgcc agcgcgtgga aggggcagtt gcgcagccgt agcgtctccc cgtcccggaa
    14941 gggctggtag ccgcgggccc gcagcgccgc caccacgtcg tcggtacgcg catccggctg
    15001 tgccgcgccc gccgccctcg ccgcggcctg tagttcccgg tccagtcccg cgtcctccag
    15061 cacctcggcg agcagccggc cggcggtgtc gtacgaccgc ggcggcacgg agacggcgtg
    15121 ctcgccctcg gcgcgccggt acagcttcgc cggccgcccc gcgccgggac cggtgcgccc
    15181 ggacagccgc cggaaggaca cggcgagcag cccggcctcg accagcttgt ccaggtggaa
    15241 ggcggccagc gaccgggaga ccccggccgc ttccgcggcg gcatcgcggg acacctcctc
    15301 gggggcggcg gcgacgcagc ggtagagccg acggcgcacg gggtcgctca gcaggcccag
    15361 tacatcgaac gtggagtctt cgtcagtcac gaaccgactc tatgaccaac gagggcttga
    15421 gaaacacggg cggcggagca gggcgcccgg ggcggacggc ggcggcgacg cccgggcacg
    15481 gggtgctcgt gctgacgccg ccggcgtggg ccttgtcgcg ggggtcggga agcgggaact
    15541 ccgcgccccc ctcgtgcgtt gcggaggacg actgatcgtt cgatgtctga cgcgacggcg
    15601 gcgccgtcgt cgggggaagt gagcaaccca tggccatggt cggcctgttc tggatcgccg
    15661 agggcgatgt gtacgtgggc gcgaagccgg ccgggctggc gcccggggta cgcctgaccc
    15721 cggagggcgt ggtgggcctc ggcgacggac agtccagcct ctgcctgtgg gaggacgtga
    15781 gcaccctgac ggtggcggac gtccccgtga agtccctgat gcgacgggtc ggcgcggtca
    15841 cggacctggc gctcgggacg gtgaaggagc tggccctgcc cgggggctcg gtctgggcgg
    15901 acgaggctcc ggcgatgatg acggtgcgcg tgggatccgc cgacggggag cgcgagctgg
    15961 gagcctacgt cgccgcggcc gtcggctacc cccagaccga gatcgacctc tcccgcgccc
    16021 tcctgtcccg cctcacggag ggcgccgcga cgatggccac gacgctggcg gcgatgtcgg
    16081 agtggggccg cgcctgggag ggcgggtcgc cccgcggggc ggaacgggag aggctgttgc
    16141 ggagctgggt gggctagagc gtttccttcg gatcgtctgg ccgaatggat gagcagggca
    16201 gcgacgtgga gtccggtcag gaagatggtg gcggtcttgg cgcggcgggt ggccggcatg
    16261 gcctgagccc tggtggtgaa cggctcggcc ggctccgccg ccgactcctc catggtccag
    16321 ccaccgaagt cggccgctga ggcgctccga cgcccgccct caccaggccg gaccgcgcca
    16381 cgaggacctg caccgggccg gcctcacgcc accttgagcg gcgtcacggc ggtggcccgg
    16441 cgcgccgtcg gccgggacac agcggcggta cgcaggggaa gccgagtggt gcccgagcta
    16501 tgtcttgtcg gcgtggtcct gggcggggcc gtgctcggtg ctgcgccgag cgctcgtctg
    16561 tattccgcga ttttcggctt tctcttgtcg ggttccgtct cccccatgta gcccctgatc
    16621 acgtacgtgc cgcccataac gcctctgcat cgctcttccg tggtgcgacc tccgcccgct
    16681 ccggacttgg ttatcccgac acgctgccga actgcgaata acgactacag tcgacttaaa
    16741 cgtggtgtcg ctcacctcgc ccgtaggagc atctgcgagg gggccgatct ggctggtaag
    16801 cgctttcaag agtgctggtg cgtgtgcgac ggtaaggtca ccaagtcccg cgcagaaaag
    16861 gaaaagaatg agactctccg tgcgtcgttc cctcggtgtc gcagcagtcg ccgcagccgc
    16921 gctggccgcc acggtcgtgc ccgccgcggc agccacggca tctcccacca cggcttccgc
    16981 catcgggccg accatcaacc gtacggactg caacgagaac agctacctcg aaatccacaa
    17041 caacgagggc cgcgacacgc tctgtttcgc caacgccgga acgatgcccg tcgccatcta
    17101 cggggtgaac tgggtcgagt ccggaaacaa tgtcgtgact ctccagttcc agcggaatct
    17161 gagcgatccg aggctcgaaa ccatcactct gcagaagtgg agctcgtgga acccaggcca
    17221 catccaccag atcatttcga tcaggattca ctgataccga agaacgtccg ggggcgcctt
    17281 tcggggcgcc cccctttttt tgtggcgcga cgccctggtc gccgatccgg cggacgtgca
    17341 cgaggtgacg atgccgggcg acgacagcca cgcattcccc ggctcacggc ggtcgcgtgg
    17401 cggtgccgat gccgccggcc gcggggcccg tcgtcgtccg ggcccgggat ctccttccgc
    17461 cagacgtcag cggccgctcc agatgaactt tccggggcgg acctccaggc ggtactggac
    17521 ctcgtgcacg gcgaggcggg ctcccagcca gcagcggtac agggcggcct cgcgcggacc
    17581 ggccagcccg ttcctgatcc ggtcacgggt gtcgttcatc cgggcgtcgg tcaggttcgc
    17641 ggcccaggcg acgtactccc ggtaggtata gccctcttcg cgggccacgg cctccagcgc
    17701 ttccttgtac tcggggagga tgtcgccgat gcgttccatg cgcacccgcc accggaagat
    17761 cgttccgtcg ctcatgcggt cggtggtcca gccgttctcg tccgtccagc ggttgtcgtg
    17821 gtcgtccccg cggtggtgac cgtccccgcg cctgaacagt gccatgcctt tctctcctcc
    17881 ttgacggtcg cggtcctgcg cgctcgcgtc ccggcgcgca ccggcggtct acgccgggct
    17941 tgccgcttgg gcggcgttgt agacggcctg ttcctcggcg ccgaagtggg tggaactcat
    18001 gttggggccc tgcacccagc ccaggatgcc gatgatctgg gcggggtcgt cgtaacggga
    18061 gaagaccccg acctggacgc ccgcaccggt ggcgggatcg aagttctgca gcagggcgcc
    18121 gccgctgcac ccgggcgact gggcgccggc cagcacgtcg ttgtagtaga cgggatcgtt
    18181 gtgggtggtg ccctgggtga ccatgagact gcggccgtcg aaggtccgct ggagcgcggc
    18241 gggcacgttg ccggggcggt agtggttgcg ttcgttgatg gtcggatagc cgaagacgtg
    18301 gtgggtctgg ttctgcggct ggccgaacgc gacctcctgg cctccggtga cctcggcgat
    18361 cgggcgggga tcgtcggggt tggccacgac gaccgcggcc atgtcacgtc ccagcagcca
    18421 gtcggcgctc cggctccagg tgtgggtgat ccactggcgg gtgacccccc agaccccgta
    18481 cggggcgatg tccttgcccg ggagccgtgt gctggaggtg tcacggggca ggttcgctcc
    18541 gtcgaatccc ggcacgaaca ccatgttggt ggcgacgacg ttgccgaagc ccacgtcgag
    18601 cggggtgtgg atgcgcaggc agtgggcggc ggtcagtacg acgctgcggt tggcgctgct
    18661 caccacgttg ccggagcacg acgacgtcga ggtggcaccg gtctccacgt ccgtgtactc
    18721 catgaagatc ttgcctgcgg tgcgtgagat gcgcccgtgc tcccgcggcc acggcctgct
    18781 gaggtcgtcc cagccgccgg ggggcgcggt cgcgtcccgg tcttcgttgt tgaggccggc
    18841 gtcggccatc ttcccgaggg tccagtactc cacctcggcc ctgagtcttt cctggtggtc
    18901 ggggccggcc gggaccagcg ggcggagttc gaaggcgggg acagcggctc gggccggggg
    18961 tgcggcggtc agcagcgcgg cggtcagggc gagcaggccg agtacggcgg tgagggcatg
    19021 tcgtgacggc atgcgggtga gcaatgcttc ccctcctcgg ggtggtcggt tcctcggggt
    19081 ggtcggtgcg gacggctgcg ccggggaggc cgatgccggc tctccgcctc gcggcggtgc
    19141 gcgtccgggg ccggcggccg gcttcacggg ttgccggtca cctcgaagcc cgcgccgtac
    19201 acgccgcctg gtgtgacggc gtcccgggcg cgcaggtcgg cgaggatgtt ggccgagctg
    19261 gtgtattcga acggcggcag ggacaaagtg atcgctttgg tgatcccggc ccaggggccc
    19321 tcggcctgga agccgttctc ctgggaggga agttcgctcc ccggtacgtg ccggacggcc
    19381 ggtccgcccg agtcacccgg caggtgggcg gccggcgacc ggtagatgcc gccggtggtg
    19441 tccatgatgg ttccgaacca cacacctgtc tggcccgcaa cgatgagttc ctcgttcccg
    19501 gtggcgagca gccgctcgga gtcgagcgcg ggccgcaggg cgttcggact ggcggttccg
    19561 ccgggaaccc gtacctcgcc ggtctgcttc aggtaagggc cctgcgagga cagcgtcacc
    19621 tgcgggacca gctcgatgat catgtagtcc ttggtcatgt gaccggtctg cgatccctcg
    19681 gggtccttga agtagcgcac gtgtccgatc gggccgaaag cgggatccgc ccggtcgtag
    19741 acgggcgcga cgtcgtccgg gatctcgcgg tccgcgtagg tgccgtcggg gtcgttgagg
    19801 cagtgaccgg ccgagatggc gatccggtgc ccgtacttgt cgttgcccac cgcgccgatg
    19861 gtgcagaagg cggacggtgt cgacggactg aaaaggatct gcatcccgtt gtggacgcgc
    19921 ttgcccgtct cggcccgggc cgcgcctgct gccacggtcc acaggaccgt gaggctcagc
    19981 accaggacgc accatcgtct gatcatgtgc caaccctgtc tgtcggaggg tgagggggag
    20041 gagcggtcag gaggacgcga acgccgcttc gagacgcggc acgaagtcga cgaggtcctg
    20101 cgcccagcag ccgctggtgt ggctgccgtc gcagtcgtcg ccccacccgg agccgtcccc
    20161 gtagtccacg taatgggaag ggtgtccgag ttggtccaga cgctccttgg cgtgctggga
    20221 cgccgaccgg acccagaact ccggttcggc ggggttgccc tgcccgttcc cggtgtacag
    20281 cgtgacgccg gtaccggccc gggccaggac gtccatgtgc gccaccggat ccgcctcgtc
    20341 ccagcgccag tcggcgccga agaccggata cggcgtgccg aagacggcgt cgctggacac
    20401 cgcaggcccg aagtcgagac tgcacgtggg gttcgaactg ccgcacagcg gggctccgat
    20461 gttcgtcagc gtggcgacga cggccgcgcg catgacggcg tgccggagcg agagttcgtt
    20521 ggcaccggag agcgaagcga cctgactgaa caggcccgga tgtctctggg cgtagtgcag
    20581 cgcgccgaag ccgcccatcg agagcccggc gacggcccgc gccctgcgcg cggaaacggt
    20641 gcggagattg gtgtcgatga acgggatcac ctgagagatg tggaagttct cccagttctg
    20701 cgccccggcg gcggtgccct ggtcgagcca gttggtgtac cagcccctcc ggcctccgtc
    20761 cgggatgacg gtgatcatcg actgggccgc ggtgagggcc gggtaggcca cgttcgggtt
    20821 gcccggatcg tccgacgcgc cgtgcaggaa gtacagcacc gggtagcgct tgtcggggcg
    20881 gtcggcgtag tcggcgggca gcaggatccg gacgcggtgc tcgccgtcga cctcgggcgt
    20941 ggtcacggtg acgacgaagt tggtggcgga gccggtggcg gtgccgacct gggtcagtcc
    21001 gaagccgtcg gtcatctccg gtgggcgcgc gcccggaccc tcggcgtgcg cggacggcgt
    21061 acccggaaga aggagggccg ccgccagggc gagggccgcc gccgtcgcac gcgtgagccg
    21121 ggtgggcaga gctgatctca tcaggtgtcc tcaagggggc ttgatgcgag gggacgggac
    21181 gggtggtcag ccggtcacgg agcatctcac cgcatcactc cacgtgacgc catacgtaca
    21241 cgtggcgcag tcgggccact ggcgccattg cgccaacccc gcagtaatct gagaggggtt
    21301 gggctgaccg gccccggttc ggcgaggggg gaagccgtgc atgacgtgtt cgacccggac
    21361 tccgaccgcg ggcgggtcta ccggttcctg gtcggtcacc cgcacgcgtc cgccccgcgg
    21421 ttggcggccg ggaccggact gagtgagacg gccgtccggg cggtgctgga ggaactcgcc
    21481 gccgaggaca tcgtgctgac ggctgattcc ggggacgcgc ggagccgttg ggaagcggtg
    21541 ccgcccaccc aggtcgtcga ggcgctgctg cggcgcgatg acgtggtgcg caccgcgttg
    21601 cggcacaccg gtacggagat ggaacggctc taccgctccg ccaggaggga cgccggtcac
    21661 tacgaggcgc tcgaagtcgt cgaggacccc gtacgcgtcc tggcggtcag caggcagctc
    21721 cagcagtcgg tgcgccacca gctccgcgcc attgacgtgc caccgtactc cggcacttcc
    21781 gaccactacc tcgcgcagga ggcgctgcag cgcgagcgca tggccgccgg cgtcgtctac
    21841 cgcgccatct accacggttc cgccttcgac gacccgatcg cctggcccaa catggcccgc
    21901 atgatcgaag ccggggaaca ggcacggacc ttggacgatc cgcccatgaa actggcgatc
    21961 cgtgacaacg atctcgcggt ggtcactctc gccgccgacg accgccccgg actcgtctcc
    22021 ctcctgatcc gtccctccgg tctgctccag gcgctctcca acaccttcga gtcgctgtgg
    22081 agactcgccg ttccggtatc ggcggcgggc atcggtacgc cgatcgacgc ccgggaccgc
    22141 cggatcctca ctctcatggc cagcggcgcc accgacgaag cgatcgccag acac
//
