LOCUS       NZ_AP024135            22499 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7484259
            Orig. end                         :: 7506758
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="30"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12499](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(231..896)
                     /locus_tag="K6K39_RS32925"
                     /old_locus_tag="EASAB2608_06740"
     CDS             complement(231..896)
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141632.1"
                     /locus_tag="K6K39_RS32925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06740"
                     /product="potassium channel family protein"
                     /protein_id="WP_086696730.1"
                     /transl_table=11
                     /translation="MDADSRARRWESRTGLPLAVASLVYLASYAVHVLAPGLPASVRLA
                     LRALQLLIWLLFAIDYGVRWRLSGTGLRFVRRHWLDTVVVLLPLMRPVRMVKTYETVER
                     RHGRPRLPLHARVIVYAGLSALLLGFAGALAVYRQEHGAPHATIRTFGDSVWWTCSTLA
                     TVGYGDVAPVTPWGRTIAVGLMACGLALLGAVTGSFSSLLLQRFSREGDEDREGPPGP"
     gene            964..1524
                     /locus_tag="K6K39_RS32930"
                     /old_locus_tag="EASAB2608_06741"
     CDS             964..1524
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016434264.1"
                     /locus_tag="K6K39_RS32930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06741"
                     /product="HIT domain-containing protein"
                     /protein_id="WP_059248268.1"
                     /transl_table=11
                     /translation="MLPSMTSEPEQQIGVGTQDAFQRLWTPHRMAYIQGENKPTGPGAD
                     DGCPFCSIPAKSDEDGLIVRRGEHVYAVLNLYPYNGGHLMTVPYRHVADYTDLTGPETA
                     ELGELTKQAMTALRTASGAQGFNIGMNQGAVAGAGIAAHLHQHIVPRWGGDTNFMPVVG
                     HTRVLPQLLADTRTMLAEAWPAA"
     gene            complement(1641..3287)
                     /locus_tag="K6K39_RS32935"
                     /old_locus_tag="EASAB2608_06742"
     CDS             complement(1641..3287)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671563.1"
                     /locus_tag="K6K39_RS32935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06742"
                     /product="hypothetical protein"
                     /protein_id="WP_059248267.1"
                     /transl_table=11
                     /translation="MSFGTEWDGPQVPVSGDEGQAATSALASAAYRDSPLEDIKKADNE
                     WHQSTVKPGRMKLFRPNLGEAFSRALVDRMLAPGRKPLIQSFGSEPQFVVEHALAANNI
                     RRERDNRLTAITVVCGLLFLPGMLGWLLVFQLRTFVARRDDKRAGTLATTLLLGVGVLA
                     ALFLIKMPFSGFWAWYARAAVVVPVLGWFWAKQICERTAKDLRARWDGLLSGTSVGAKV
                     PEAVPRGPDQTAAEALRQSLARLSAEQQSNSVFYAGPKGILGMGTRWGAWQLAEDLVPA
                     DPGREIHPFRSWDVVRAIHDQLSLLERGPLNTGGFPKPSIRHWIVTPIGEKATAVSRPE
                     GTDVEAFQVKPHAIQDICNKQQFGSGDRHYLGVQWTLWDGQLVITMLITVTVLHETLRI
                     EVTGHALGPVNSLFTSKPEAPTKEVAKSFKPWENRTIKLPLVSTDEVVRLAVRAPLTWY
                     PPLLNWLGGSLGLPEPFGLRHAWADQPWRHRFMADDALRAATPVLRVVHSAAIKVLEDN
                     GVNTEKFGARSAFLSGNVQDPTPRKADVYDA"
     gene            complement(3500..5701)
                     /locus_tag="K6K39_RS32940"
                     /old_locus_tag="EASAB2608_06743"
     CDS             complement(3500..5701)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671562.1"
                     /locus_tag="K6K39_RS32940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06743"
                     /product="elongation factor G-like protein EF-G2"
                     /protein_id="WP_059248266.1"
                     /transl_table=11
                     /translation="MGDKAQTHHPGAAGRALAADHPASVRNVVLVGHSGSGKTTLVEAL
                     ALTAGAVNRAGRVEDGGTVSDYDDIEHRQQRSVQLSLVPVEWDGIKINLLDTPGYADFV
                     GELRAGLRAADAALFVVSASDGVDGSTRMVWEECAAVGMPRAIVITHLEAARADFEEMT
                     RICAEAFGGDDPDAVLPLYLPLRGPEGPDGHAPVTGLTGLLSRKLFDYSTGERKESEPG
                     EDQLPDIEEARNRLIEGIIAESEDETLMDRYLGGEQVDIKTLVEDLERAVARGSFFPVL
                     AAAPAAEGARQGLGTVELLDLITGGFPTPFEHPLPGVTTIDGKPRELKPCDTSGPLVAE
                     VVKTSSDPYVGRISLVRVFSGTLRPDRTVHVSGHGLADRGHEDHDVDEKIAALTMPFGK
                     QQRPVTHAVAGDLVCVAKLSRAETGDTLSAKDDPLLMEPWQMPDPLLPLAIQAHSKADE
                     DKLSQGLARLVAEDPTMRLEQNQDTHQVVLWCLGEAHADVALERLRNRYGVQVDVVPHK
                     VSLRETFATKAGGRGRHVKQSGGHGQYAICEIEVEPLPGGSGIEFVDKVVGGAVPRQFI
                     PSVEKGVRAQAAKGVAAGYPLVDVRITLLDGKAHSVDSSDAAFQTAGALALREAAAGAK
                     IHLLEPVAEVTVLVGDEYVGPVMSDLSSRRGRLLGTEQVGTGRTLIRAEVPEFEIGRYA
                     VDLRSLSHGTARFDRSYARHEPMPPQIAERIREQAGDEV"
     gene            5968..6687
                     /gene="pgsA"
                     /locus_tag="K6K39_RS32945"
                     /old_locus_tag="EASAB2608_06744"
     CDS             5968..6687
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pgsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325113.1"
                     /locus_tag="K6K39_RS32945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06744"
                     /product="phosphatidylinositol phosphate synthase"
                     /protein_id="WP_086696731.1"
                     /transl_table=11
                     /translation="MGQPEATRAAAPTTVGKAMLNKYARAFFTRVLTPFAAFLIRRGVS
                     PDTVTLIGTAGVVAGALVFYPRGEFFWGTVVITLFVFSDLVDGNMARQLGRSSRWGAFL
                     DSTLDRVADGAIFGGFALWYAGQGDDNVLCAVSIFCLASGQVVSYTKARGESIGLPVAV
                     NGLVERAERLVISLVAAGFAGLHAFGVPGIQWLLPIALWIVAVGSLVTLIQRVVTVRRE
                     SAEAEAAARQSTSEAAQ"
     gene            6684..7592
                     /locus_tag="K6K39_RS32950"
                     /old_locus_tag="EASAB2608_06745"
     CDS             6684..7592
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671560.1"
                     /locus_tag="K6K39_RS32950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06745"
                     /product="phosphatidylinositol mannoside acyltransferase"
                     /protein_id="WP_086696732.1"
                     /transl_table=11
                     /translation="MSTADRLTDALYGLGWSTVKKLPEPVAARLGRTIADLAWKQRGKG
                     VQRLEANYARVVPDATPERLAELSRAGMRSYLRYWMESFRLPAWSAERVRSGFEAKDLH
                     HLTDGLAAGRGVILALPHLANWDLAGAWVTTALRTPFTTVAERLKPETLYDRFVAYREG
                     LGMEVLPHSGGSAFGTLARRLRDGGLVCLVADRDLSASGVEVDFFGERARMPAGPALLA
                     QQTGALLLPVTLWYDDSPVMKGQVHPPVDVPGSGTRVEKTSVMTQALADAFASGIAEHP
                     EDWHMLQRLWLADLDPAKGPS"
     gene            7589..8752
                     /locus_tag="K6K39_RS32955"
                     /old_locus_tag="EASAB2608_06746"
     CDS             7589..8752
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004990569.1"
                     /locus_tag="K6K39_RS32955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06746"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_086696733.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.8e-28,
                     bitscore: 98.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGIVCPYSWDVPGGVQFHIRDLAEYFLRLGHEVSVLAPADDDT
                     PLPPYVVSAGRAVPVPYNGSVARLNFGFLSAARVRRWLHEGAFDVVHIHEPTSPSLGLL
                     TCWAASGPIVATFHTSNPRSRAMIAAYAILQAALEKISARIAVSEYARRTLVEHLGGDA
                     VVIPNGVDVDFFAKADPNPQWQGDTIGFIGRIDEPRKGLPVLMKALPRILAARPQTRLL
                     VAGRGDEEAAVADLPAELRSRVEFLGMVSDEDKARLLRSVDLYVAPNTGGESFGIILVE
                     AMSAGAPVLASDLDAFVQVLDQGAAGEVFANENADALADAAVRLLDDPARRAGLRERGS
                     AHVRRFDWSTVGADILSVYETVTAGAAAVGADERPPGLRARFGLARD"
     gene            9063..9608
                     /locus_tag="K6K39_RS32960"
                     /old_locus_tag="EASAB2608_06747"
     CDS             9063..9608
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570237.1"
                     /locus_tag="K6K39_RS32960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06747"
                     /product="hypothetical protein"
                     /protein_id="WP_059248262.1"
                     /transl_table=11
                     /translation="MTATLIWILVALVAIGVYLSWTAGRLDRLHVRMDAARAALDAQLL
                     RRASVAQELATSGVLDPAASIVLYEAAHAARQAAEEHREVAESELSQALRAVFADPAQV
                     EAVREAPGGEEAARELAEAVRRVPMARRFHNDAVGAARRLREHRKVRWFRLAGHAPFPL
                     AFEMDDEPPAALTDRSRA"
     misc_feature    9638..9649
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(9642..9653)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            9827..9967
                     /locus_tag="K6K39_RS32965"
                     /old_locus_tag="EASAB2608_06748"
     CDS             9827..9967
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="K6K39_RS32965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06748"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_107117974.1"
                     /transl_table=11
                     /translation="MNENIEISNSEPYEPPTVVEVGEFNEDTLGFIGWGKDIFGHYSGG
                     F"
     CDS_motif       9827..9913
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MNENIEISNSEPYEPPTVVEVGEFNEDTL"
                     /locus_tag="K6K39_RS32965_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9914..9967
                     /prepeptide="core"
                     /locus_tag="K6K39_RS32965_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="1.80"
                     /molecular_weight="1827.0"
                     /monoisotopic_mass="1825.8"
                     /core_sequence="GFIGWGKDIFGHYSGGF"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MNENIEISNSEPYEPPTVVEVGEFNEDTL"
                     /leader_location="[9826:9913](+)"
     gene            10001..11836
                     /locus_tag="K6K39_RS32970"
                     /old_locus_tag="EASAB2608_06749"
     CDS             10001..11836
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090023.1"
                     /locus_tag="K6K39_RS32970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06749"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_059248261.1"
                     /sec_met_domain="Asn_synthase (E-value: 8.6e-33, bitscore:
                     113.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTGFVVLPDTAAAGEARAAVPWEAPQEFPHASGRPWLVGRWSP
                     GDLTVVTAGPVRLAVIGICPVTAPRLTELAARIRTVSDVDALAASLPGSCHVAASVDGQ
                     VRFQGSVTGLRRVFHARLHQVDVAADRADVLAAMTGAGIDETALALRVATGGFLPPPLA
                     DRPLWSGISAPAPDHCLVWERDRVREVRWWRPPAPELSLAAGAEAVGKALAGALDERAP
                     GHGRLSSDLSGGMDSTSLCFLAARRVPDLVTFRWGEAEAGNDDAAFAAHAIGLLDRAEH
                     LVVPPGELPLLFADADRPVDPEEAYPFVRTIARTRYTARLLADAGSRRHLAGHGGDELF
                     TPFPGYLHGLLRRRPLTALRHVRGYAALKRWPVLPTLAALARPGDEAAWWRAQADGLTA
                     PPPPRRRPVFGWGVWPMRAPAWATDTAIEATREALRHTAGTARPLSTDLGQHQLLLAVR
                     TSAPWYRLLARVFADAGVQLDSPFFDDRVVEAVLSVRVHEHAGPWRYKPLLAEAMRGTV
                     PDAVLGRSTKGEFSDEANRGLRHHMAGILELFEDSALAARGLIDPGVLRARLLAPQSDN
                     ATSIALEPLIGCETWLRAATRPTPAWRFDARASSS"
     gene            11838..12071
                     /locus_tag="K6K39_RS32975"
                     /old_locus_tag="EASAB2608_06750"
     CDS             11838..12071
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330917.1"
                     /locus_tag="K6K39_RS32975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06750"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_260335862.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.5e-24,
                     bitscore: 82.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-14, bitscore: 53.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISTATDDGTVLLNERTGRYWQLNKTGTRVLQGLLDGQEAAGIAA
                     ELADRYGIGRQQAERDVAAVIERLSGAKLVIS"
     aSDomain        11841..12065
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K6K39_RS32975_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.90E-26"
                     /identifier="RREFam002.1"
                     /label="K6K39_RS32975"
                     /locus_tag="K6K39_RS32975"
                     /protein_end="76"
                     /protein_start="1"
                     /score="82.9"
                     /tool="antismash"
                     /translation="ISTATDDGTVLLNERTGRYWQLNKTGTRVLQGLLDGQEAAGIAAE
                     LADRYGIGRQQAERDVAAVIERLSGAKLVI"
     gene            12068..12499
                     /locus_tag="K6K39_RS32980"
                     /old_locus_tag="EASAB2608_06751"
     CDS             12068..12499
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123203.1"
                     /locus_tag="K6K39_RS32980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06751"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_094374521.1"
                     /sec_met_domain="PF13471 (E-value: 9.8e-27, bitscore: 92.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMSVVLAERRRLPPHRRVVPLLVVGVARLLAKVKPARLRAVLEF
                     ARRGAAPATVDQALAAREAVVSVSLRCAGQGCLQRSIATALLCRVRGTWPTWCTGVRTH
                     PFAAHAWVEAEGQLVGEGHPKGHFKTLMSIPPVSRDQDR"
     gene            12681..13586
                     /gene="pdxS"
                     /locus_tag="K6K39_RS32985"
                     /old_locus_tag="EASAB2608_06752"
     CDS             12681..13586
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pdxS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380720.1"
                     /locus_tag="K6K39_RS32985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06752"
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="WP_014671557.1"
                     /transl_table=11
                     /translation="MSTIENQAPETGTARVKRGMAEQLKGGVIMDVVTPEQAKIAEDAG
                     AVAVMALERVPADIRKDGGVARMSDPDMIEGIIDAVSIPVMAKSRIGHFVEAQVLQSLG
                     VDYIDESEVLTPADEVNHSDKWAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGN
                     VVEAVRHLRQIKNEIARLRGFDNHELYAAAKELRAPYELVKEVAELGKLPVVLFSAGGV
                     ATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFYDDPKIIADASRNLGEA
                     MVGINCDTLPETERYANRGW"
     gene            13609..14214
                     /gene="pdxT"
                     /locus_tag="K6K39_RS32990"
                     /old_locus_tag="EASAB2608_06753"
     CDS             13609..14214
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /GO_function="GO:0004359 - glutaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /GO_process="GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pdxT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549036.1"
                     /locus_tag="K6K39_RS32990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06753"
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="WP_059248258.1"
                     /transl_table=11
                     /translation="MNTPVIGVLALQGDVREHLIALAAADAVARPVRRPEELAEVDGLV
                     LPGGESTTISKLAVLFGLMEPLRARVRDGMPVYGTCAGMIMLADKILDPRSGQETVGGI
                     DMIVRRNAFGRQNESFEAALDVKGIPGDPVEGVFIRAPWVESVGAGAEVLAEHDGHIVA
                     VRQGNALATSFHPELTGDHRVHSLFVDMVRANRAPESL"
     gene            14290..15042
                     /locus_tag="K6K39_RS32995"
                     /old_locus_tag="EASAB2608_06754"
     CDS             14290..15042
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988230.1"
                     /locus_tag="K6K39_RS32995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06754"
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_059248257.1"
                     /transl_table=11
                     /translation="MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNIEVAARMGGADPDG
                     NPTLYDAIQKAKKSSVPNKNIDSAVKRGAGLEAGGADYETIMYEGYGPNGVAVLIECLT
                     DNRNRAASEVRVAMTRNGGSMADPGSVSYLFNRKGVVIVPKGELTEDDVLGAVLDAGAE
                     EVNDLGENFEVLSEPTDLVAVRTALQEAGIDYESAEANFVPTMQVELDEEGAKKIFKLI
                     DALEDSDDVQNVFANFDVSDEIMEKVDA"
     misc_feature    15129..15142
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.34"
                     /tool="antismash"
     misc_feature    15133..15146
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            15167..15706
                     /gene="ruvC"
                     /locus_tag="K6K39_RS33000"
                     /old_locus_tag="EASAB2608_06756"
     CDS             15167..15706
                     /EC_number="3.1.21.10"
                     /GO_function="GO:0008821 - crossover junction DNA
                     endonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671554.1"
                     /locus_tag="K6K39_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06756"
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="WP_059248256.1"
                     /transl_table=11
                     /translation="MRVLGVDPGLTRCGVGVVEGVAGRPLTMLGVGVVRTPADADLSHR
                     LLAVEQGIEQWLDEHRPEFVAVERVFSQHNVRTVMGTAQASAVAMLCAARRGIPVALHT
                     PSEVKAAVTGSGRADKAQVGAMVTRLLRLAAPPKPADAADALALAICHIWRAPAQNRLQ
                     QAVARHAVHATKGRTA"
     gene            15703..16308
                     /gene="ruvA"
                     /locus_tag="K6K39_RS33005"
                     /old_locus_tag="EASAB2608_06757"
     CDS             15703..16308
                     /EC_number="3.6.4.12"
                     /GO_component="GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671553.1"
                     /locus_tag="K6K39_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06757"
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="WP_221335270.1"
                     /transl_table=11
                     /translation="MIAFVSGTVAALAPDAAVVEVGGVGMAVQCTPNTLSTLRLGQPAK
                     LHTSLVVREDSLTLYGFADDDERQVFALLQTASGVGPRLAQAMLAVHTPDALRRAVATG
                     DEKALTAVPGIGKKGAQKLLLELKDRLGEPVGAPAVGAPVSQGWRDQLHAALIGLGYAT
                     READEAVTAVAPQAEQAGGTPQVGQLLKAALQTLNRAR"
     gene            16335..17405
                     /gene="ruvB"
                     /locus_tag="K6K39_RS33010"
                     /old_locus_tag="EASAB2608_06758"
     CDS             16335..17405
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570231.1"
                     /locus_tag="K6K39_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06758"
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="WP_059248254.1"
                     /transl_table=11
                     /translation="MNWDDPTDTPAAERLVDSVADREDQAVEAALRPKDLGEFIGQEKV
                     REQLDLVLRAARARGATADHVLLSGAPGLGKTTLSMIIAAEMGAPIRITSGPAIQHAGD
                     LAAILSSLQEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPF
                     TLVGATTRAGLLPPPLRDRFGFTAHMEFYEPHELQRVVHRSAHLLDVEIEPDGAAEIAG
                     RSRGTPRIANRLLRRVRDYAQVKADGLITRDIAAAALAVYEVDARGLDRLDRAVLEALL
                     KLFGGGPVGLSTLAVAVGEERETVEEVAEPFLVREGLLARTPRGRVATPAAWAHLGLTP
                     PRSPAAGNGQQDLFGA"
     gene            17584..18060
                     /gene="yajC"
                     /locus_tag="K6K39_RS33015"
                     /old_locus_tag="EASAB2608_06759"
     CDS             17584..18060
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046497.1"
                     /locus_tag="K6K39_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06759"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_059248253.1"
                     /transl_table=11
                     /translation="MNAYTLLPFIVLIAAMFLMTRSAKKKQQQAVEMRNQMQPGSGVRT
                     IGGMYATVKEVNEDTVLLDAGPGVDLLFAKNAIGAVLSDDEYNRIVHGIEHDLKSDADL
                     VPDDASSLTETDETDGSAAAAAASDDKIDLGKKDAAEAKAEDEPKKSDGDSDAK"
     gene            18203..19981
                     /gene="secD"
                     /locus_tag="K6K39_RS33020"
                     /old_locus_tag="EASAB2608_06760"
     CDS             18203..19981
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380713.1"
                     /locus_tag="K6K39_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06760"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_221335271.1"
                     /transl_table=11
                     /translation="MAAPKRGRSASAQSKPGRSLALILIAIVALTGGMFLSGHTTPRLG
                     IDLAGGTSITLKAKADQGSAINKANMDTAVDIMNRRVNGLGVSEAEVQTQGTDNIIVNI
                     PKGTNSKEAQEQVGTTAKLYFRPVLAQEASGAAAQSPSPSASGSSSPKPSGSPSPSASA
                     GEKASSSGSASPTASATSQGRAVSDALKADPTPSASASGSGKPSATPSPSSGSGSGADA
                     KLQAQYAALDCTKATDRAKAGKNTKPGDSIVACGEINGAWYKYLLGPAAVDGTEVKKAQ
                     AVFDTQGASGWQVQMTFTKKGADKFADITGELATKPQPQNEFGIVLDGEVVSSPFVQQA
                     ITGGQAEISGSFKQEEAQGLANMLSYGALPLSFQEQSVTTVTAALGGEQLRAGLLAGAI
                     GLALVVIYLVVYYRGLSIVAMASLLVSAILTYVIMSLLGPAIGFALNLPAVCGAIVAIG
                     ITADSFIVYFERIRDEIREGRTLRPAVERAWPRARRTVLVSDFVSFLAAAVLFIVTVGK
                     VRGFAFTLGLTTLLDVVVVFFFTKPLMTLLARRRFFADGHKWSGLDPKSLGAQPPLRRT
                     RRPAGPAAGPVDPKEA"
     gene            19985..21094
                     /gene="secF"
                     /locus_tag="K6K39_RS33025"
                     /old_locus_tag="EASAB2608_06761"
     CDS             19985..21094
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117479.1"
                     /locus_tag="K6K39_RS33025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06761"
                     /product="protein translocase subunit SecF"
                     /protein_id="WP_094374524.1"
                     /transl_table=11
                     /translation="MSKLGNLGARLHRGEISYDFVGKRKIWYGISILITITAIVGLAVR
                     GLNMGIEFQGGAVFTTPTKMSTSVAQAEKYADEASGHQSVVQKLGNGSLRIQIAGIDTA
                     QSDKVKQELAKDLKLDPEKLAADLVGPSWGEQIANKAWEGLAIFMVLVTIYLAIAFEWR
                     MAVAALVALIHDITITTGIYALVGFEVTPGTVIGLLTILGYSLYDTVVVFDSLKEQTKD
                     ITKQTRFTYGEIANRSINGTLVRSINTTVVALLPVAGLLFIGGGFLGAGTLNDISLSLF
                     VGLAAGAYSSIFIATPLVADLKEREPALKALTKRVLAKRAQAGAEEEPVGAPAAAGDDT
                     AEATPAVVGPRNQPASRGRGRGRTSGKRR"
     gene            21091..21630
                     /locus_tag="K6K39_RS33030"
                     /old_locus_tag="EASAB2608_06762"
     CDS             21091..21630
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019066369.1"
                     /locus_tag="K6K39_RS33030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06762"
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_221335272.1"
                     /transl_table=11
                     /translation="MTDIQELLLSRIRDVADYPEPGVMFKDITPLLADPAAFTALTDVL
                     AEIAANTGATKVVGLEARGFILGAPVAVRAGLGFIPVRKAGKLPGATLRQAYDLEYGSA
                     EIEVHAEDLTAGDRVLIVDDVLATGGTAEAAIQLIQRAGAAVCGLAVLMELGFLGGRDR
                     LEPALDGAPLEALLQV"
ORIGIN
        1 ctcctcctcg gaccggatgc agaagaagat ccgcaacgcc cagaagcaga aggtgccctt
       61 catggtcatc gcgggcgacg aggacatgtc gaacggctcg gtgtccttcc gctaccgcga
      121 cggctcgcag gagaacggca tcccgttcga cgaggccatc gcgaagatcg cgcaggtcgt
      181 ggcggaccgg gcccaggtct gaaccggctg agccgcgcgg gcccccggga tcacggtccc
      241 gggggccctt ccctgtcctc gtccccctcc cgggagaacc gctgcagcag cagcgacgag
      301 aacgaccccg tcaccgcgcc cagcagggcc agaccgcagg ccatgaggcc gacggcgatc
      361 gtgcggcccc acggggtgac cggggccacg tcgccgtagc cgaccgtcgc cagggtcgag
      421 caggtccacc acaccgagtc gccgaaggtc cggatcgtgg cgtgcggggc cccgtgttcc
      481 tgccggtaca cggcgagcgc gccggcgaag cccagcagca gcgcggagag accggcgtac
      541 acgatcacgc gcgcgtgcag cggcagccgg ggacggccgt gccggcgctc caccgtctcg
      601 tacgtcttca ccatccgcac cggccgcatc aggggcagca gcacgaccac cgtgtccagc
      661 cagtgccgtc gtacgaaccg cagccccgtg ccgctgagcc gccagcgcac cccgtagtcg
      721 atcgcgaaca gcagccagat gaggagttgc agggcgcgca gcgcgagacg gaccgacgcg
      781 ggcaggcccg gggccaggac gtgcaccgcg taggaggcga ggtagaccag ggaggcgacg
      841 gcgagcggga gacccgtccg gctctcccag cgccgcgcac ggctgtcggc gtccaccggc
      901 caagcttggc cggagagtgc cggcacccct ccccggcgac acgccgggga ggggtgaagc
      961 catatgctgc ctagcatgac gagtgagccg gagcagcaga tcggagtggg gacgcaggac
     1021 gcgttccagc gcctgtggac cccccaccgg atggcctaca tccagggcga gaacaagccg
     1081 accggcccgg gggccgacga cggctgcccc ttctgctcga tcccggccaa gtccgacgag
     1141 gacggactga tcgtccggcg cggcgagcac gtgtacgcgg tcctcaacct gtacccgtac
     1201 aacggcggcc acctgatgac cgtgccgtac cggcacgtgg ccgactacac ggacctgacc
     1261 gggccggaga ccgcggagct gggggagctg accaagcagg ccatgaccgc cctgcggacc
     1321 gcgtccggcg cgcagggttt caacatcggc atgaaccagg gcgcggtcgc gggcgccggc
     1381 atcgccgccc atctgcacca gcacatcgtc ccgcgctggg gcggcgacac caacttcatg
     1441 ccggtcgtcg gccacacgcg ggtgctgcca cagctgctgg cggacacccg cacgatgctc
     1501 gcggaggcct ggccggcggc ctgaacagcc cggccggcgt tcgcggacga ggccgttcac
     1561 ggccgatgcg gggcttggga gcggcggccc ccggcggcca caccccgccc cgcacccgca
     1621 ccggccgagg cgccggaggc ctacgcgtcg tagacgtcgg ccttccgcgg ggtcggatcc
     1681 tggacgttgc cgctcaggaa cgccgagcgg gcgccgaact tctccgtgtt cacgccgttg
     1741 tcctccagga ccttgatcgc ggccgagtgg accacgcgca gcaccggtgt ggccgcgcgc
     1801 agcgcgtcgt cggccatgaa gcggtgacgc cacggctggt cggcccaggc gtgccgcaga
     1861 ccgaacggct cgggcaggcc gagggagccg cccagccagt tcagcagcgg cgggtaccag
     1921 gtcagcgggg cgcgcacggc gagccgcacc acctcgtcgg tgctcaccag cggcagcttg
     1981 atcgtgcggt tctcccaggg cttgaaggac ttggcgacct ccttggtcgg cgcctcaggc
     2041 ttgctggtga agagcgagtt caccggtccc agcgcgtgcc ccgtgacctc gatgcgcagc
     2101 gtctcgtgca gcacggtgac ggtgatcagc atcgtgatga ccagctgccc gtcccagagc
     2161 gtccactgca cgcccaggta gtgccggtcg ccgctgccga actgctgctt gttgcagatg
     2221 tcctgtatgg cgtggggctt gacctggaac gcctcgacgt cggtgccctc gggccgggac
     2281 accgccgtgg ccttctcgcc gatcggggtg acgatccagt gccgtatcga cggcttgggg
     2341 aagccgccgg tgttgagcgg gccgcgctcc aggagggaca gctggtcgtg gatcgcgcgg
     2401 acgacgtccc agctgcggaa ggggtggatc tcccgaccgg ggtcggcggg gacgaggtcc
     2461 tcggcgagct gccaggcgcc ccagcgggtg cccatgccga gtatgccctt ggggccggcg
     2521 tagaagaccg agttggactg ctgctcggcg ctcagccggg ccagggactg gcgcagcgcc
     2581 tcggcggcgg tctggtcggg cccgcgcggc acggcctccg ggaccttggc gccgacgctg
     2641 gtgccggaga gcagcccgtc ccagcgggcc cgcaggtcct tggcggtgcg ctcgcagatc
     2701 tgcttggccc agaaccagcc gagcaccggg acgacgacgg ccgcgcgggc gtaccacgcc
     2761 cagaagccgg agaacggcat cttgatcagg aacagcgcgg cgagcacgcc gacgcccagc
     2821 agcagcgtgg tggccagcgt gccggcccgt ttgtcgtcgc gtctggcgac gaaggtgcgc
     2881 agctggaaga cgagcagcca gccgagcatc ccgggcagga agagcagccc gcagacgacg
     2941 gtgatggcgg tcagccggtt gtcccgctcc cggcggatgt tgttggcggc cagcgcgtgc
     3001 tcgacgacga actgcggttc cgagccgaag gactggatga gcggcttgcg gcccggggcg
     3061 agcatccggt cgacgagggc ccgggagaac gcctcgccga gattgggccg gaacagcttc
     3121 atccggccgg gcttgaccgt cgactggtgc cactcgttgt cggccttctt gatgtcctcg
     3181 agcgggctgt cccggtacgc cgcggacgcc agcgcggagg tcgccgcctg cccctcgtcg
     3241 cccgagacgg gtacctgggg cccgtcccac tccgttccaa acgacattcc gcccccatcg
     3301 ccgccggtgc cgttcctgcg gccttcccga cttccctgct gcgcacacct gttggaccgg
     3361 tcgccgtgcc gataccggcc gccgccggac gggcacggca cgacgtgtat ccaggtgatc
     3421 agcgtatccg gcggcaccga caacgcgtgg gcggacggcc gaagccgccc gcccgtgcgc
     3481 ccagttgtgc gccggcgtac tagacctcgt ccccggcctg ttcgcggatg cgttcggcga
     3541 tctgcggcgg catcggctcg tgccgggcgt agctgcggtc gaaacgggcc gtgccgtgcg
     3601 agagcgagcg caggtcgacg gcgtaccggc cgatctcgaa ctccggaacc tccgcgcgga
     3661 tcaacgtccg tccggtgccc acctgttcgg tgccgagcag ccggccgcgg cggctggaga
     3721 ggtcgctcat cacggggccc acgtactcgt cgccgaccag gacggtcacc tcggcgaccg
     3781 gctccagcag atggatcttc gcgcccgccg ccgcctcgcg cagcgcgagc gcgcccgccg
     3841 tctggaaggc ggcgtcggag gagtccaccg agtgggcctt gccgtccagc agcgtgatcc
     3901 gcacgtccac caggggatag ccggcggcga cgcccttggc ggcctgggcc cgcacgccct
     3961 tctcgacgga cgggatgaac tggcggggca ccgcgccgcc gacgaccttg tccacgaact
     4021 cgatgccgga gccgcccggc agcggctcca cctcgatctc gcagatcgcg tactggccgt
     4081 ggccgccgga ctgcttgacg tgccggccgc gcccgccggc cttggtcgcg aacgtctccc
     4141 ggagggagac cttgtgcggg acgacgtcga cctggacgcc gtagcggttg cgcagccgct
     4201 ccagggcgac gtcggcgtgg gcctcgccca ggcaccacag gacgacctgg tgggtgtcct
     4261 ggttctgctc cagacgcatg gtcgggtcct cggcgaccag ccgggccagg ccctgggaga
     4321 gcttgtcctc gtcggccttg ctgtgcgcct ggatggcgag cggcagcagc gggtcgggca
     4381 tctgccaggg ctccatcagg agcgggtcgt ccttggcgga gagggtgtcg ccggtctcgg
     4441 cgcggctgag tttcgccacg cagaccaggt cgccggcgac cgcgtgcgtg accgggcgct
     4501 gctgtttgcc gaagggcatg gtcagagcgg cgatcttctc gtcgacgtcg tggtcctcgt
     4561 gcccgcggtc ggcgaggccg tgcccggaga cgtgcaccgt ccggtccggg cgcagggtgc
     4621 cggagaagac gcggaccagc gagatccggc cgacgtaggg gtcggaggag gtcttgacga
     4681 cctcggcgac cagcgggccg ctggtgtcgc acggcttcag ctcgcggggc ttgccgtcga
     4741 tggtggtgac cccggggagc gggtgctcga agggggtcgg gaagccgccg gtgatcaggt
     4801 ccagcagctc caccgtgccg agaccctgtc tggcgccctc ggcggccggg gcggcggcca
     4861 gcacggggaa gaaggacccg cgggcgacgg cccgctccag gtcctcgacg agcgtcttga
     4921 tgtcgacctg ctcgccgccc agatagcggt ccatgagggt ctcgtcctcg ctctcggcga
     4981 tgatcccctc gatgagccgg ttgcgggcct cctcgatgtc cggcagctgg tcctcgccgg
     5041 gctcggactc cttgcgctcc ccggtcgagt agtcgaacag cttccgcgac agcagtccgg
     5101 tcagcccggt cacgggcgcg tgcccgtcgg ggccctcggg tccgcgcagc ggcaggtaca
     5161 ggggcaggac ggcgtcgggg tcgtcgccgc cgaaggcctc cgcgcagatc cgggtcatct
     5221 cctcgaagtc cgcgcgcgcg gcctccaggt gcgtgatcac gatcgcgcgg ggcatcccga
     5281 cggccgcgca ctcctcccac accatccggg tggagccgtc gaccccgtcc gaggcggaga
     5341 cgacgaacag ggccgcgtcg gcggcccgca gcccggcccg cagctccccg acgaagtcgg
     5401 cgtagccggg ggtgtccagg aggttgatct tgatgccgtc ccattcgacg ggcaccaggg
     5461 agagctgcac ggagcgctgc tgccggtgct cgatgtcgtc gtagtcggag accgtgccgc
     5521 cgtcctcgac gcggcccgcc cggttcaccg cccccgcggt cagcgccagc gcctccacga
     5581 gggtcgtctt tcccgagccg gagtggccga ccagcaccac gttccgtacg gacgcggggt
     5641 ggtcggccgc cagagccctg ccggcggccc cggggtggtg tgtctgtgcc ttgtcgccca
     5701 tgatcctgcc tcccgtgcac ggtgaggtca ctgtgggcgc ggacacgcgg aaccctcccc
     5761 cggaggggca cccccagctg gcggctccgg cgacgcccgc ggttcttcga gctttccact
     5821 cccgtcacgt ggcgtccata cgaaggacta cgaagggtgc gcacggggca ccgttcgcgt
     5881 cacgcacgct tcgcgcgcgg gagcgcgctc cggttcgcgg cgcggctgcg ggtgcccgcc
     5941 cgtcacgcat acgcgcgcgt ggctacgatg ggccagccgg aggccaccag ggccgcggcg
     6001 ccaacgaccg tcgggaaggc catgctgaac aagtacgcgc gtgcattctt cacgcgtgtc
     6061 ctcacaccgt tcgccgcgtt tctcatccgc cggggcgtga gccccgacac ggtcacgctc
     6121 atcggcacgg ccggtgtggt cgcgggcgcg ctggtcttct accccagggg cgagttcttc
     6181 tggggcacgg tcgtgatcac cctgttcgtc ttctccgacc tggtcgacgg caacatggcc
     6241 cgccagctgg gccgctccag ccgctggggc gcgttcctgg actccaccct ggaccgggtc
     6301 gccgacggcg cgatcttcgg aggcttcgcg ctctggtacg ccggccaggg cgacgacaac
     6361 gtgctgtgcg cggtgtcgat cttctgtctg gccagcggcc aggtggtgtc gtacaccaag
     6421 gcacgcggcg agtcgatcgg gctgccggtc gccgtcaacg ggctcgtcga gcgcgccgag
     6481 cgactggtga tctcgctggt cgcggccggt ttcgcgggtc tgcacgcgtt cggcgtgccg
     6541 ggcatccagt ggctgctgcc gatcgcgctg tggatcgtcg ccgtgggcag cctggtcacg
     6601 ctgatccagc gggtcgtcac cgtccgccgc gagtccgccg aggcggaggc ggcggcccgg
     6661 cagagcacga gcgaggcggc acagtgagca ccgccgaccg gctcaccgac gcgctgtacg
     6721 gcctgggctg gagcactgtc aagaagctcc ccgagcccgt cgcggcccgc ctcggccgga
     6781 ccatcgccga cctcgcctgg aagcagcgcg gcaagggcgt acagcggctg gaggcgaact
     6841 acgcgcgcgt ggtgcccgac gccacccccg agcggctcgc cgagctgtcc cgcgcgggca
     6901 tgcgctcgta cctgcgctac tggatggagt ccttccggct gccggcctgg agcgccgagc
     6961 gggtgcggtc gggcttcgag gcgaaggacc tccaccacct gaccgacggg ctcgccgccg
     7021 gccggggcgt gatcctcgcc ctgccgcacc tggccaactg ggacctggcc ggcgcctggg
     7081 tcaccaccgc gctgcggacg ccgttcacga cggtcgccga acgcctgaag cccgagacgc
     7141 tctacgaccg cttcgtcgcc taccgcgagg gcctcggcat ggaggtcctg ccgcacagcg
     7201 gcggctccgc cttcggcacg ctggcccgca gactgcgcga cggcggcctg gtctgcctgg
     7261 tcgccgaccg cgatctgtcc gcctccggcg tcgaggtcga cttcttcggg gagagggccc
     7321 ggatgcccgc gggcccggcc ctgctcgcgc agcagaccgg cgcgctgctg ctgcccgtca
     7381 ccctctggta cgacgactcg ccggtcatga aggggcaggt gcatccaccg gtcgacgtcc
     7441 ccgggtcagg cacgcgggtt gagaagacgt ctgtcatgac acaggccctg gccgacgcct
     7501 tcgcctccgg catcgccgaa cacccggagg actggcacat gctccagcgg ctgtggctcg
     7561 ccgacctcga ccccgcgaag ggaccctcgt gagaatcggg atcgtctgcc cgtactcctg
     7621 ggacgtgccc ggtggcgtcc agttccacat ccgcgacctc gccgagtact tcctccggct
     7681 cggccacgag gtctccgtcc tggccccggc cgacgacgac accccgctgc cgccgtacgt
     7741 cgtctccgcc ggccgcgcgg tcccggtgcc gtacaacggc tcggtggccc ggctgaactt
     7801 cgggttcctg tcggccgcgc gggtgcggcg ctggctgcac gagggcgcct tcgacgtggt
     7861 gcacatccac gagccgacct cgccctcgct gggcctgctg acctgctggg cggcgtccgg
     7921 tccgatcgtg gccacgttcc acacctccaa cccgcgctcc cgcgcgatga tcgccgcgta
     7981 cgcgatcctc caggccgcgc tggagaagat cagcgcgcgg atcgcggtca gcgagtacgc
     8041 ccgccgcacg ctggtcgagc acctcggcgg ggacgcggtg gtcatcccca acggcgtcga
     8101 cgtggacttc ttcgccaagg ccgaccccaa tccgcagtgg cagggcgaca ccatcggctt
     8161 catcggccgc atcgacgagc cccgcaaggg cctgccggtg ctgatgaagg cgctgccgcg
     8221 gatcctggcc gcccggccgc agacccggct gctcgtcgcg ggccgcggcg acgaggaggc
     8281 ggccgtcgcg gatctgcccg cggagctgcg ctcgcgcgtg gagttcctcg gcatggtcag
     8341 cgacgaggac aaggcgcgcc tgctgcgcag cgtggacctg tacgtcgcgc ccaacaccgg
     8401 cggcgagagc ttcggcatca tcctggtcga ggcgatgtcc gcgggcgccc ccgtgctcgc
     8461 ctccgacctg gacgccttcg tgcaggtcct cgaccagggc gcggccggcg aggtcttcgc
     8521 caacgagaac gccgacgcgc tcgcggacgc ggccgtacgg ctgctggacg acccggcccg
     8581 ccgagccgga ctgcgcgagc gcggcagcgc ccatgtgcgg cgcttcgact ggtccacggt
     8641 cggcgcggac atcctgtccg tctacgagac ggtcacggcc ggcgcggcag cggtcggcgc
     8701 ggacgaacgg cccccgggcc tgcgtgcacg gttcggcctg gcccgggact gacgcggacg
     8761 ccgtccggtc cggggcgggg cggcctgggc gcgggggagc acggtgcggg gcctccgggg
     8821 agtcggcgtc cgggcccgcg cctgtcggcg cgttcaccga ggctcaagat cccggcttca
     8881 ccgaggctca ggaccccggc ttcgccgagc ccggcagccc gctccgccga gccccggaat
     8941 ccggcaatca ccgtccctgg cctggctcga cacaagggcc cgggcggggg cgcgggcgcg
     9001 gggcgctcgg gcggtcgggg cgggcgccgg gggcgtccgc gggcagccga tagccttccg
     9061 ccgtgaccgc aaccctcatc tggatcctcg tcgcactcgt cgccatcggt gtgtacctca
     9121 gctggacggc cgggcggctg gaccggctgc acgtgcggat ggacgccgca cgggccgcgc
     9181 tcgacgcgca gctgctgcgg cgggcctcgg tggcgcagga gctggcgacc tcgggcgtgc
     9241 tggacccggc cgcgtcgatc gtgctgtacg aggccgcgca cgcggcacgg caggccgcgg
     9301 aggagcaccg ggaggtcgcc gagagcgaac tgagccaggc gctgcgggcg gtcttcgcgg
     9361 acccggccca ggtggaggcc gtgcgcgagg ccccgggcgg cgaggaggcg gcccgtgagc
     9421 tggccgaggc ggtccgccgg gtgccgatgg cccgccgctt ccacaacgac gccgtgggtg
     9481 ccgcccgcag gctccgcgag caccgcaagg tccgctggtt ccggctggcc ggccacgccc
     9541 ccttcccgct ggccttcgag atggacgacg aaccgccggc ggcgctgacg gaccgttcgc
     9601 gggcgtgaac ctcgatttca agccacccgc acgacggcga agtgaacgct ttccctgcgc
     9661 ctcttcatga tcatttccgc aggccatcgg cgatcttgcc ggtgcctgtg cgggagccga
     9721 gcgccctctg tgacgtgagt ggaaatcgga ttgatcatgc ccttcggtca tatgtacgat
     9781 tcggtgagta gctgaccagc tgctttctgt gactgaggag ggcgttatga acgagaacat
     9841 cgagatctcg aactccgagc cgtacgagcc gccgaccgtg gtggaggtcg gagagttcaa
     9901 cgaggacacc ctgggcttca tcggctgggg caaggacatc ttcggccact actcgggcgg
     9961 cttctgatcc tcggttgtcg gttctcggag agctgagcga atgagtagca ccgggttcgt
    10021 ggtcctgccg gacacggcgg ccgcgggcga ggctcgcgcg gccgtcccct gggaggcgcc
    10081 gcaggagttc ccgcacgcct ccggccggcc gtggctggtg ggccggtggt cacccggtga
    10141 cctcaccgtg gtcaccgcgg gcccggtgcg cctggcggtg atcgggatct gcccggtcac
    10201 cgccccccgg ctcaccgaac tcgccgcccg gatccgcacg gtgtccgacg tggacgccct
    10261 ggcggcgtcc ctgcccggct cctgtcatgt ggcggcatcc gtcgacgggc aggtccgctt
    10321 ccagggcagc gtcaccggac tgcgccgggt cttccacgcc cggctgcacc aggtggacgt
    10381 ggccgccgac cgggccgatg tgctcgcggc gatgaccggc gccgggatcg acgagacggc
    10441 gctggccctg cgcgtggcca caggaggatt cctgccgccc ccgctggccg accggcccct
    10501 gtggtccggg atctccgcgc cggccccgga ccactgcctg gtctgggagc gggaccgggt
    10561 gcgcgaggtg cggtggtggc ggccgccggc gccggaactg tccctcgccg cgggtgccga
    10621 ggccgtcgga aaggccctgg ccggtgccct ggacgagcgg gcccccggtc acggccggct
    10681 cagctctgac ctgtccggcg gcatggactc gacatcactg tgcttcctcg ccgcgcgccg
    10741 cgtgcccgac ctggtgacct tccggtgggg tgaggccgag gccggcaacg acgacgccgc
    10801 cttcgccgcc cacgccatcg gcctgctgga ccgcgccgag catctcgtcg taccccccgg
    10861 cgaacttccg ctgctgttcg ccgacgcgga ccgcccggtg gacccggagg aggcctatcc
    10921 cttcgtccgc accatcgcgc gcacccggta cacggcgcgg ctgctcgccg acgcgggctc
    10981 gcgccggcac ctcgcgggac acggcgggga cgagctgttc acaccgttcc ccggctacct
    11041 gcacggactg ctccggcgcc gcccgctgac cgccctgcgg cacgtccggg gctacgccgc
    11101 cctgaaacgc tggcccgtgc tgcccaccct cgccgcgctg gcccgccccg gtgacgaggc
    11161 cgcctggtgg cgggcccagg ccgacgggct caccgccccg cccccgccgc ggcgccggcc
    11221 cgtcttcggg tggggcgtgt ggccgatgcg ggcaccggcg tgggccaccg acacggcgat
    11281 cgaggcgacc cgcgaggccc tgcggcacac cgcgggcacg gcgcggccgc tctccaccga
    11341 tctgggccag caccagctgc tcctcgcggt gcgcaccagt gccccctggt accggctgct
    11401 ggcccgtgtc ttcgccgacg ccggtgtgca gctcgactcg ccgttcttcg acgaccgcgt
    11461 ggtcgaggcc gtcctgtcgg tacgggtgca cgaacacgcc gggccgtggc ggtacaagcc
    11521 gctgctggcc gaggcgatgc gcggcaccgt gccggacgcc gtgctgggcc gctccaccaa
    11581 gggcgagttc agcgacgagg ccaaccgggg acttcgccac cacatggccg ggatcctgga
    11641 gctgttcgag gactcggccc tggccgcccg cggactgatc gaccccggcg tactgcgcgc
    11701 ccggctgctg gcgccccagt cggacaacgc cacgagtatc gcgctggaac ccctgatcgg
    11761 ctgcgagacc tggctgcgcg ccgccacccg acccactcct gcttggaggt tcgacgcccg
    11821 tgcgtcttca tcctgacgtg atcagcaccg ccaccgacga cggcacggta ctgctcaacg
    11881 aacgcaccgg acggtactgg cagttgaaca agaccggcac ccgcgtgctc caggggctgc
    11941 tggacgggca ggaggccgcc ggcatcgccg ccgaactcgc ggaccggtac ggcatcggcc
    12001 gccagcaggc cgagcgcgac gtggccgccg tgatcgagcg cctgagcggc gcgaagctgg
    12061 tgatctcgtg agcatgtccg tcgtgctggc cgaacgccgc aggctccctc cgcaccgccg
    12121 tgtggtcccc ctgctggtcg tgggcgtcgc ccggctgctg gccaaggtca aacccgcccg
    12181 gctgcgcgcg gtcctggaat tcgcccgccg cggcgcggca ccggcgacgg tcgaccaggc
    12241 gctcgcggcc cgcgaggcgg tcgtgtccgt cagcctgcgc tgtgccggac agggctgtct
    12301 gcaacgctcg atcgccacgg ctctcctgtg ccgggtgcgc ggtacgtggc ccacctggtg
    12361 caccggcgtg cgcacccatc ccttcgccgc ccacgcctgg gtcgaggccg aggggcagct
    12421 cgtcggcgag ggccatccca agggccactt caagaccctg atgtccatcc cgccggtctc
    12481 ccgcgaccag gatcgctgac cccggcggag ggggagggaa ccgggcgcgg ggaggcggga
    12541 tccgcgcgcg aggaggcggg atccgcgcgc gtggcggcca aaaggatcca ccggcttgtc
    12601 attggccctt gctgtggcct ggtccactcg cgtttcctca tcggtgcaga aacccctctt
    12661 caccatcagt gaggtcaccc gtgtccacca tcgagaacca ggctcccgag accggtaccg
    12721 cccgcgtgaa gcgcggcatg gccgagcagc tcaagggcgg cgtgatcatg gacgtcgtca
    12781 cgccggagca ggcgaagatc gccgaggacg cgggcgccgt cgccgtcatg gccctggagc
    12841 gggtcccggc cgacatccgc aaggacggcg gcgtggcccg catgtccgac ccggacatga
    12901 tcgagggcat catcgacgcc gtctcgatcc cggtcatggc caagtcccgc atcggccact
    12961 tcgtcgaggc ccaggtgctg cagtccctcg gcgtcgacta catcgacgag tccgaggtgc
    13021 tcaccccggc cgacgaggtc aaccactccg acaagtgggc cttcaccacc cccttcgtct
    13081 gcggtgcgac caacctgggc gaggccctgc gccgcatcgc cgagggcgcc gcgatgatcc
    13141 gctccaaggg cgaggccggc accggcaacg tcgtcgaggc cgtccgccac ctgcgccaga
    13201 tcaagaacga gatcgcccgc ctgcgcggct tcgacaacca cgagctgtac gccgccgcca
    13261 aggagctgcg cgccccgtat gagctggtca aggaggtcgc cgagctgggc aagctgccgg
    13321 tcgtgctgtt ctccgccggt ggcgtggcca ccccggccga cgccgccctg atgcgtcagc
    13381 tcggcgccga gggcgtcttc gtcggctccg gcatcttcaa gtccggcgac ccggccaagc
    13441 gcgccgccgc catcgtgaag gccaccacct tctacgacga cccgaagatc atcgcggacg
    13501 cgtcccgcaa cctcggcgag gccatggtcg gcatcaactg cgacaccctc cccgagaccg
    13561 agcgctacgc gaaccgcggc tggtaaccca cacaggtaac ggcaccccat gaacactcct
    13621 gtcataggcg tcctggccct ccagggcgac gtacgggagc acctcatcgc cctggccgcg
    13681 gccgacgccg tggccaggcc ggtgcggcgc cccgaggaac tcgccgaggt ggacggcctc
    13741 gtgctgcccg gcggcgagtc caccaccatc tccaagctcg ccgtcctgtt cggcctgatg
    13801 gagcccctcc gcgcgcgcgt gcgggacggc atgccggtct acggcacctg cgccggcatg
    13861 atcatgctcg ccgacaagat cctcgacccg cgctcgggcc aggagaccgt cggcggcatc
    13921 gacatgatcg tgcgccgcaa cgccttcggg cggcagaacg agtcgttcga ggccgcgctc
    13981 gacgtcaagg gcatcccggg cgatcctgtg gagggcgtct tcatccgcgc gccctgggtg
    14041 gagtccgtgg gcgccggggc cgaggtgctc gccgagcacg acggccacat cgtcgccgta
    14101 cgccagggca acgcgctcgc cacctcgttc cacccggaac tcaccggcga ccaccgcgtg
    14161 cactcgctgt tcgtcgacat ggtgcgcgcc aaccgggcac cggagtcctt gtaggatctc
    14221 cgggggtccc cccggccttt cgaccagggg gcgttcgtac aggatgggtt acgcgaagga
    14281 gacaggcaga tgtccggcca ctctaaatgg gccacgacga agcacaagaa ggccgtgatc
    14341 gacgccaagc gcggcaagct cttcgcgaag ctgatcaaga acatcgaggt cgcggcccgc
    14401 atgggcggtg ccgacccgga cggcaacccg acgctgtacg acgccatcca gaaggcgaag
    14461 aagtcgtcgg tcccgaacaa gaacatcgac tccgcggtca agcgcggcgc gggcctggag
    14521 gccggcggcg ccgactacga gacgatcatg tacgagggtt acggcccgaa cggtgtcgcg
    14581 gtgctcatcg agtgcctcac cgacaaccgc aaccgcgccg cctccgaggt ccgcgtcgcc
    14641 atgacccgca acggcggctc catggccgac ccgggctcgg tgtcgtacct gttcaaccgc
    14701 aagggcgtgg tgatcgtccc caagggcgag ctgaccgagg acgacgtgct cggcgccgtc
    14761 ctggacgccg gtgccgagga ggtcaacgac ctcggcgaga acttcgaggt gctcagcgag
    14821 ccgaccgacc tcgtcgccgt ccgcaccgcc ctgcaggagg ccggcatcga ctacgagtcg
    14881 gccgaggcca acttcgtgcc gaccatgcag gtcgagctgg acgaagaggg cgccaagaag
    14941 atcttcaagc tgatcgacgc gctggaggac agcgacgacg tgcagaacgt cttcgccaac
    15001 ttcgacgtga gcgacgagat catggagaag gtcgacgcgt aacgcgcacg gctgaccgac
    15061 cgggccgacg ggacacaccc ccgtcggccc gtcgcgttgt acggcgttgt cagtggcacc
    15121 cgatagcctg cacgaacatg caatcgggtg atccgtggga gggcgcgtgc gtgttctggg
    15181 ggtggacccc ggcctgacgc ggtgcggggt cggcgtggtc gagggggtcg ccggccgccc
    15241 gctcaccatg ctcggcgtcg gcgtcgtccg gacccccgcg gacgccgacc tcagccaccg
    15301 gctgctcgcc gtggagcagg gcatcgagca gtggctggac gaacaccggc cggagttcgt
    15361 cgccgtggag cgcgtcttca gccagcacaa cgtgcgcacg gtcatgggca ccgcccaggc
    15421 cagcgccgtc gccatgctgt gcgccgcccg gcgcggcatc cccgtcgccc tgcacacccc
    15481 cagcgaggtc aaggccgccg tcaccggcag cgggcgcgcc gacaaggcgc aggtcggggc
    15541 catggtgacc cggctgctcc ggctcgccgc accgcccaag ccggccgacg ccgccgacgc
    15601 cctcgcgctc gccatctgcc acatctggcg ggcccccgcc cagaaccgac tccagcaggc
    15661 cgtcgcccgg catgcagtcc acgcaacgaa aggccgtacg gcatgatcgc cttcgtcagc
    15721 ggcacggtcg ccgcgctcgc ccccgacgcc gcggtcgtcg aggtcggcgg cgtcggcatg
    15781 gccgtccagt gcacgccgaa caccctgtcg accctccggc tcggccagcc cgccaagctg
    15841 catacctccc tggtcgtgcg tgaggactcg ctcaccctgt acggcttcgc ggacgacgac
    15901 gaacgccagg tcttcgcact gctccagacc gcgagcggcg tcggtccgcg gctggcgcag
    15961 gcgatgctcg ccgtgcacac cccggacgcg ctgcgccgcg cggtcgccac cggtgacgag
    16021 aaggccctca ccgccgtgcc cggcatcggc aagaagggcg cccagaagct gctgctggag
    16081 ctgaaggacc ggctcggcga gcccgtcggc gcacccgccg tcggcgcgcc cgtcagccag
    16141 ggctggcgcg accagctgca cgcggccctg atcgggctcg gctacgccac ccgcgaggcc
    16201 gacgaggcgg tgaccgccgt cgcgccccag gccgagcagg cgggcggcac accccaggtg
    16261 gggcagctgc tgaaggccgc cctgcagacc ctgaaccgcg cccgctgact cgcgccaccc
    16321 gctaggagat cttcgtgaac tgggacgacc cgaccgacac ccccgccgcc gagcggctgg
    16381 tggactctgt cgccgaccgg gaggaccagg ccgtcgaggc cgccctgcgc cccaaggacc
    16441 tcggcgagtt catcggccag gagaaggtcc gcgaacagct cgacctggtc ctgcgcgccg
    16501 cacgcgcgcg cggcgccacc gccgaccacg tgctgctctc cggcgcgccc ggcctcggca
    16561 agaccaccct ttcgatgatc atcgccgccg agatgggcgc ccccatccgc atcacctcgg
    16621 gccccgccat ccagcacgcc ggcgacctcg ccgcgatcct ctcctccctc caggagggcg
    16681 aggtgctctt cctcgacgag atccaccgca tgtcccggcc cgccgaggag atgctgtaca
    16741 tggcgatgga ggacttccgc gtcgacgtca tcgtcggcaa gggccccggc gccaccgcga
    16801 tcccgctgga gctgccgccg ttcaccctgg tcggcgccac cacccgggcg ggcctgctgc
    16861 ccccgccgct gcgcgaccgc ttcggcttca ccgcgcacat ggagttctac gagccccatg
    16921 agctgcaacg ggtcgtccac cgctcggcgc acctgctgga cgtcgagatc gagccggacg
    16981 gcgccgccga gatcgccggc cgctcccggg gcacgccccg catcgccaac cgcctgctgc
    17041 gccgcgtccg cgactacgcg caggtcaagg ccgacgggct gatcacccgc gacatcgccg
    17101 ccgccgccct cgcggtgtac gaggtcgacg cgcgcggcct cgaccggctc gaccgcgccg
    17161 tcctggaagc cctgctgaag ctgttcggcg gcggaccggt cggcctgtcc acgctcgccg
    17221 tcgcggtggg ggaggagcgg gagaccgtgg aggaggtcgc cgaacccttc ctggtccgcg
    17281 aaggactgct cgcccgcacc ccgcgcggcc gggtcgccac gcccgcggcc tgggcgcatc
    17341 tcggcctcac cccgccgcgc tcaccggccg cgggaaacgg acaacaggat ctgttcgggg
    17401 cctgacggcc gccacccggc gaggacggtg gccccggcag gaacccaggt gccatgctga
    17461 gcgttgttcc atgcgagcgg actcgcttag actccgccga tgccgccctt gcgggcggcg
    17521 ccgaccacac ccccatccaa caggccgctc acccgcgcgg tcgcgcgaag gaaattccgt
    17581 cccgtgaatg cctataccct tctccccttc atcgtgctca tcgcggccat gttcctgatg
    17641 acgcgatcgg ccaagaagaa gcagcagcag gccgtcgaga tgcggaacca gatgcagccc
    17701 ggctccggcg tccgcacgat cggggggatg tacgcgacgg tcaaggaggt caacgaggac
    17761 acggtcctcc tcgacgccgg accgggcgtc gacctcctct tcgccaagaa cgccatcggc
    17821 gccgtcctct ccgacgacga gtacaaccgc atcgtccacg gcatcgagca cgacctgaag
    17881 tccgacgccg acctggtccc ggacgacgcc tcctccctca ccgagaccga cgagaccgac
    17941 ggatccgccg ccgctgccgc cgcctccgac gacaagatcg acctcggtaa gaaggacgcc
    18001 gccgaggcga aggcggagga cgagccgaag aagtccgacg gcgactccga cgcgaagtag
    18061 tcacgccccg ggaggcgcgg tggcggcatg atggcgcccc gcgcatcccg ggcgcgtctg
    18121 tttcccgcac gggagcccga ttccatgtca tggccgaccg cgccgaccgg gcgcggggcg
    18181 gcccgagagg gagtacgaga aggtggcagc acctaagagg ggccgaagcg cgagcgccca
    18241 gagcaagcca gggcgctcgc tggccctcat cctgatcgcc atcgtggcgc tcaccggggg
    18301 gatgttcctc tccgggcaca ccaccccgcg tctcggtatc gacctcgccg gtggcacgag
    18361 catcacgctg aaggcgaagg ccgaccaggg gtccgcgatc aacaaggcca acatggacac
    18421 cgcggtcgac atcatgaacc gccgtgtcaa tggcctgggc gtctccgagg cggaggtgca
    18481 gacccagggg accgacaaca tcatcgtcaa catccccaag ggcaccaact ccaaggaggc
    18541 ccaggagcag gtcggcacca ccgcaaagct ctacttccgg ccggtcctgg cccaggaggc
    18601 cagcggggcc gccgcgcaga gcccctcgcc gagcgcctcc ggcagctcct cgccgaagcc
    18661 gagcggcagc ccgtcgccga gcgcctcggc cggtgagaag gcttcctcgt ccggctccgc
    18721 gtcccccacg gcctcggcga cctctcaggg ccgcgccgtc agcgacgcgc tgaaggccga
    18781 ccccactccc tcggcgagcg cctccggcag cggcaagccg tcggccaccc cgtcgccctc
    18841 gtccggcagc ggctccggcg cggacgccaa gctccaggcc cagtacgccg ccctggactg
    18901 caccaaggcc accgaccgtg ccaaggccgg gaagaacacc aagcccggcg actccatcgt
    18961 ggcctgcggc gagatcaacg gcgcctggta caagtacctg ctcggcccgg ccgccgtgga
    19021 cggcaccgag gtgaagaagg cccaggccgt cttcgacacc cagggcgcct ccggctggca
    19081 ggtccagatg accttcacca agaagggcgc cgacaagttc gccgacatca ccggcgagct
    19141 ggccaccaag ccccagccgc agaacgagtt cggcatcgtc ctcgacggcg aggtcgtctc
    19201 cagcccgttc gtccagcagg ccatcaccgg cggccaggcg gagatctccg gcagcttcaa
    19261 gcaggaggag gcccagggcc tcgccaacat gctgtcgtac ggcgccctgc cgctgtcctt
    19321 ccaggagcag tcggtcacca ccgtcaccgc cgcgctcggc ggtgagcagc tgcgcgccgg
    19381 tctgctcgcc ggcgcgatcg gcctcgccct ggtcgtgatc tacctggtgg tctactaccg
    19441 cggtctgtcc atcgtggcca tggcctccct gctggtctcc gcgatcctca cctacgtgat
    19501 catgtcgctg ctcggcccgg ccatcggctt cgcgctgaac ctgccggccg tctgcggtgc
    19561 catcgtcgcc atcggtatca ccgcggactc gttcatcgtg tacttcgaac gcatccggga
    19621 cgagatccgc gagggccgca cgctgcgtcc cgccgtcgag cgggcctggc cgcgcgcccg
    19681 gcgcacggtc ctggtctccg acttcgtgtc gttcctcgcc gccgcggtgc tgttcatcgt
    19741 gaccgtcggc aaggtgcggg gcttcgcctt cacgctgggc ctgaccaccc tgctcgacgt
    19801 ggtcgtcgtc ttcttcttca cgaagccgct gatgacgctt ctggcccgcc gcaggttctt
    19861 cgcggacggc cacaagtggt ccgggctcga cccgaagagc ctgggtgccc agccgccgct
    19921 gcgccgtacc cgccgtcccg ccggtcccgc cgccggcccc gtcgacccga aggaggcgtg
    19981 agcgatgtcg aaactcggca acctcggcgc tcgactgcac cgcggcgaga tctcctacga
    20041 cttcgtcggc aagcgcaaga tctggtacgg catctcgata ctgatcacca tcacggccat
    20101 cgtcggcctg gcggtgcgcg gcctgaacat gggcatcgag ttccagggcg gcgcggtctt
    20161 cacgacgccc acgaagatga gcacgtcggt cgcccaggcg gagaagtacg ccgacgaggc
    20221 ctccggccac cagtcggtcg tgcagaagct cggcaacggc agcctgcgca tccagatcgc
    20281 cggtatcgac accgcccagt ccgacaaggt caagcaggaa ctggccaagg acctgaagct
    20341 cgaccccgag aagctcgccg ccgacctggt cggcccgagc tggggcgagc agatcgccaa
    20401 caaggcctgg gagggcctgg cgatcttcat ggtcctggtg acgatctacc tggcgatcgc
    20461 cttcgagtgg cgcatggccg tcgcggcgct cgtcgcgctg atccacgaca tcaccatcac
    20521 gaccggtatc tacgccctgg tcggcttcga ggtcacgccc ggcacggtca tcggtctgct
    20581 gaccatcctc ggttactcgc tctacgacac ggtcgtcgtc ttcgacagcc tcaaggagca
    20641 gacgaaggac atcaccaagc agacccggtt cacctacggc gagatcgcca accggtcgat
    20701 caacggcacc ctggtccgct ccatcaacac cacggtcgtc gccctgctgc cggtcgccgg
    20761 tctgctcttc atcggcggcg gcttcctcgg cgcgggcacg ctcaacgaca tctccctgtc
    20821 gctgttcgtc ggcctcgcgg ccggtgccta ctcgtcgatc ttcatcgcca cgccgctcgt
    20881 cgccgacctc aaggagcgcg agccggcgct gaaggccctc accaagcggg tgctggccaa
    20941 gcgcgcccag gccggtgcgg aggaggagcc cgtgggggcc cctgccgccg ccggtgacga
    21001 caccgcggag gccacgcccg ccgtggtggg cccgcgcaac cagcccgcgt cccgtggccg
    21061 gggccgcggc cgtacctcgg ggaagcgccg atgaccgaca tccaggagct gctgctcagc
    21121 cgcatccgcg acgtcgccga ctacccggag ccgggcgtga tgttcaagga catcaccccg
    21181 ctgctggccg acccggcggc cttcaccgcg ctcaccgacg tgctggccga gatcgccgcc
    21241 aacaccggcg cgaccaaggt cgtcggcctg gaggcccggg gcttcatcct cggcgccccg
    21301 gttgccgtcc gcgcgggctt gggcttcatc ccggtccgca aggcgggcaa gctgcccgga
    21361 gccaccctgc gccaggcgta cgacctggag tacggctcgg cggagatcga ggtgcacgcg
    21421 gaggacctga cggccggcga ccgcgtcctg atcgtggacg acgtcctggc caccggcggc
    21481 accgccgagg ccgcgatcca gctcatccag cgcgcgggcg ccgcggtctg cggcctcgcg
    21541 gtcctgatgg agctgggctt cctgggcggt cgcgaccgtc tggagccggc cctggacggg
    21601 gctccgctgg aggcactgct gcaggtctga gcggctcacg cacgcacggc cgccccggca
    21661 caccggggcg gccgtccgcg ttccgggcac ccttccgggc ggacccgcgg ccaccggcgg
    21721 gacacccgtc gcacgccccg ggaacacctc cggagcacct ccggtccacc tcccggaatc
    21781 ccacggcagc cccccgcgtt gcacggattg acggtcctca cagccgcctg caggcgatga
    21841 ccgggcgcgg gatcgctacc attggggttt ccggagcctg accgggggac ccggatcgcg
    21901 cacgaggagt cctcttgcca gacgaggccc agccactgac cgccgccaag cccgagtccg
    21961 cctcggcctc cgcggccaag cccgcgccga acgcttccca cgtgaagaac gacccccgcg
    22021 ggacggtcga gcacgcccag gcggcgcccg tcgagaagac cgccgagtcc tcgcgcccca
    22081 agccgtcccc cacgctcgac tccgcccgcg cgggaggaac cccctcggcc gagcgcccgg
    22141 tccagccgcc cgtggtgcgc cagccggccg cgcagcccac ccgcaccggc tcctccaacc
    22201 gcgtccgggc ccgcctcgcc cgcctcggcg tccagcgcgc gaacccgtac aacccggtcc
    22261 tggagccgtt gctgcggata gtccgcagca acgaccccaa gatcgagaac tccacgctgc
    22321 gccagatcga gcgcgcctac caggtcgccg agcgctggca ccgcgggcag aagcgcaaga
    22381 gcggcgaccc gtacatcacg cacccgctcg ccgtcaccac catcctcgcc gagctgggca
    22441 tggacccggc cacgctgatg gcggggctgc tgcacgacac cgtcgaggac accgagtac
//
