LOCUS       NZ_AP024135            22578 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7000335
            Orig. end                         :: 7022913
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22578
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="27"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22578
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22578
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12578](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12578)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(721..741)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(735..748)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            978..2171
                     /locus_tag="K6K39_RS30925"
                     /old_locus_tag="EASAB2608_06330"
     CDS             978..2171
                     /EC_number="2.3.1.29"
                     /GO_function="GO:0008890 - glycine C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (45-388). E-value:
                     1.7e-72. Score: 236.5. Matches aSDomain:
                     nrpspksdomains_K6K39_RS30925_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549634.1"
                     /locus_tag="K6K39_RS30925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06330"
                     /product="glycine C-acetyltransferase"
                     /protein_id="WP_221335144.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.2e-70, bitscore:
                     236.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDTVRDDLRATLDEIRAAGLHKPERVIDTPQSATVNVTAGGRPG
                     EVLNFCANNYLGLADHPEVIAAAHQALDRWGYGMASVRFICGTQEVHKELEARLSAFLG
                     QEDTILYSSCFDANGGVFETLLGEEDAVISDALNHASIIDGIRLSKARRFRYANRDLAD
                     LEARLKEASDARRRLIVTDGVFSMDGYVAPLSEICDLADRYDAMVMVDDSHAVGFVGPT
                     GRGTPELHGVMDRVDIITGTLGKALGGASGGYVAARAEIVALLRQRSRPYLFSNTLAPV
                     IAAASLKVLDLLESADDLRVRLAENTKLFRSRMTEAGFDVLPGDHAIAPVMIGDAAEAA
                     RMAELLLERGVYVIGFSYPVVPQGQARIRVQLSAAHSTDDVNRAVDAFIAARAELAV"
     aSDomain        1113..2141
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS30925_Aminotran_1_2.1"
                     /evalue="1.70E-72"
                     /label="K6K39_RS30925_Aminotran_1_2.1"
                     /locus_tag="K6K39_RS30925"
                     /protein_end="388"
                     /protein_start="45"
                     /score="236.5"
                     /tool="antismash"
                     /translation="EVLNFCANNYLGLADHPEVIAAAHQALDRWGYGMASVRFICGTQE
                     VHKELEARLSAFLGQEDTILYSSCFDANGGVFETLLGEEDAVISDALNHASIIDGIRLS
                     KARRFRYANRDLADLEARLKEASDARRRLIVTDGVFSMDGYVAPLSEICDLADRYDAMV
                     MVDDSHAVGFVGPTGRGTPELHGVMDRVDIITGTLGKALGGASGGYVAARAEIVALLRQ
                     RSRPYLFSNTLAPVIAAASLKVLDLLESADDLRVRLAENTKLFRSRMTEAGFDVLPGDH
                     AIAPVMIGDAAEAARMAELLLERGVYVIGFSYPVVPQGQARIRVQLSAAHSTDDVNRAV
                     DAF"
     gene            2203..3105
                     /locus_tag="K6K39_RS30930"
                     /old_locus_tag="EASAB2608_06331"
     CDS             2203..3105
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330490.1"
                     /locus_tag="K6K39_RS30930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06331"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_059254627.1"
                     /transl_table=11
                     /translation="MIEARRLHILRAVADHRTVTAAAAALYLTPSAVSQQLTALEQETG
                     HRLVERGAKGVRLTPAGEILLSHTNAVLAQLERAEAELAAYGSGEAGTVTVAAFATGIA
                     QVVAPAVARLAGSAPGIKIRVQDAEGDASLPMVLDRQVDVAVAVEYRGAPSADDPRLTH
                     VPLYAEPFDAVVPVGHRLADAPEVPLAELAKDPWIGPYPGNPCHDVVVLACESAGFQPR
                     LEHSSDDFRAVVALASADAGVALVPRSALRGMDLTGVVVRPVDGVAPTRRVFAAVRRGA
                     EGHPLIRPVLTALGEAAQA"
     gene            3152..3718
                     /locus_tag="K6K39_RS30935"
                     /old_locus_tag="EASAB2608_06332"
     CDS             3152..3718
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676229.1"
                     /locus_tag="K6K39_RS30935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06332"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_059254628.1"
                     /transl_table=11
                     /translation="MRSEEPVDLLLGARLAELRAQHGWSLGELAERSGVSRSTLSRAER
                     AETSPTAAQLNRLCHVYGRTMSQLLSEVEAAPVPLVRAAEQQVWEDRASGFVRRSVSPP
                     HSGLRGELVEGRLTPGADLAYDRPPVPGLEQHLWLLAGALEVTAGERTHRLDAGDCLRM
                     RVTGATRFRCPGPTEARYVLAVVRP"
     gene            3715..4236
                     /locus_tag="K6K39_RS30940"
                     /old_locus_tag="EASAB2608_06333"
     CDS             3715..4236
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676230.1"
                     /locus_tag="K6K39_RS30940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06333"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_086703871.1"
                     /transl_table=11
                     /translation="MRVEHWTGAQVHDRADDLAALLTDTVAAGASVGFLAPLGHAEAVA
                     WWRERAAATAAGRLAVWTALDPADRVTGTVGLAFPDKPNSGHRAELVKLMVHRSARGRG
                     LGRLLLTTAERAAAAAGRTLLHLDTETGSPAEQLYRSAGWTEAGTIPDYAASPAGELRP
                     TTLYYKRLGG"
     gene            4267..4626
                     /locus_tag="K6K39_RS30945"
                     /old_locus_tag="EASAB2608_06334"
     CDS             4267..4626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389074.1"
                     /locus_tag="K6K39_RS30945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06334"
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_059254630.1"
                     /transl_table=11
                     /translation="MPDAEAVRRIALSLPDTTEKIAWSMPTFRVAGKMFATLPEDETSI
                     AVRCPKVERDELVLAEPEKFWIADHEAQFAWVRARLAALEDEEELRDILADSWRQAAPT
                     RLLDAHPELGLPPGA"
     gene            4730..6022
                     /locus_tag="K6K39_RS30950"
                     /old_locus_tag="EASAB2608_06335"
     CDS             4730..6022
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676232.1"
                     /locus_tag="K6K39_RS30950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06335"
                     /product="MFS transporter"
                     /protein_id="WP_221335145.1"
                     /transl_table=11
                     /translation="MTGTDARRDTAARGVRRAAAGSPAVWSRDFALFFAARAVARLGDT
                     MLPVALAAGLLEHGYGAGAVGLAMASTAAAFAGLVVFGGVVADRFSTRKLMIGADLVRL
                     GAQALAAGLFFTGHVVLWQICAIGFVNGVAGAVFQPGVASTVPRLAADVQGANGAIRIA
                     ESAAQLAGPAVAGVLVGLASPGGVFAAHATTYALSALCLLLLRLPPLPAGPRAASGSAL
                     RAFRADLADGWREFRSRAWLWGVIAVWCLYMIAVWGPTVPLVATEVVRHHGPGAYGLVN
                     SALGVGTVIGGLLALRLRPRRMLRAGAFSLFAFFGFPAAVGAGLGVPAMAAGAALAGAG
                     MSFWGVMWATTVQTQVPADVLNRIHAYDVAGSLAMMPVGQALVGPAAGVLGAGHVLLTA
                     GAVSLLVAAILLAVPPIRDLPRADTPAPTAH"
     gene            complement(6175..7098)
                     /locus_tag="K6K39_RS30955"
                     /old_locus_tag="EASAB2608_06336"
     CDS             complement(6175..7098)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676233.1"
                     /locus_tag="K6K39_RS30955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06336"
                     /product="transketolase family protein"
                     /protein_id="WP_059254632.1"
                     /transl_table=11
                     /translation="MDTMRDRFAPVVSRLLDEDPRVAVVLAEIGVDGFRDAMRRHPDRV
                     INVGIREQLLVGAAAGLALTGLRPVVHTFASFLVERPFEQLKLDLGHQDAGAVLVSAAA
                     SFDWPAGGFTHMAPGDVALLDTLDGWTVHVPGHPDEAETLLHHAVAAGDDKVYVRLSVQ
                     SNRQGRVIDGRHFSTVREGRGGVVVAVGPVLDAVLAATEGLDVTVLYATTVRPFDAAGL
                     RRATEAAGTDVVLVEPYLAGTSTAAVSEALADVPHRVLGLGVGRRELRRYGTIEEHVAA
                     HGLDAASLRERIDRFVGAGRVAAGRG"
     gene            complement(7133..7840)
                     /locus_tag="K6K39_RS30960"
                     /old_locus_tag="EASAB2608_06337"
     CDS             complement(7133..7840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191647.1"
                     /locus_tag="K6K39_RS30960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06337"
                     /product="transketolase"
                     /protein_id="WP_221335146.1"
                     /transl_table=11
                     /translation="MTTTAEQSRTYGYDDLPRLMGLMTGDEKHGPAATSTLDVLWVLYD
                     RVLRVGPERRDDPARDRFLLSKGHGPMAYYAVLAAKGFVPVDWLPGFGSYDSPLGHHPD
                     RVLVPGAEIGSGSLGHGLPIAVGTALGLRAQGRPDPAVWVLIGDAELDEGSNHEAIAFA
                     GPAGLDRLHTVVIDNSSASHALPGGIAARFEAAGWSAVTVDGRDHEALYAAFTAPHPGR
                     PHVVVARVEPKNA"
     misc_feature    complement(7831..7851)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.4"
                     /tool="antismash"
     tRNA            7966..8039
                     /anticodon=(pos:7008335..7008337,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="K6K39_RS30965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Pro"
     gene            7966..8039
                     /locus_tag="K6K39_RS30965"
     gene            complement(8121..10004)
                     /locus_tag="K6K39_RS30970"
                     /old_locus_tag="EASAB2608_06338"
     CDS             complement(8121..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="K6K39_RS30970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06338"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_221335147.1"
                     /transl_table=11
                     /translation="MTGATVPHGGRADAAGSGRSTLAAVVTMYRLTAGHRGAIAVAVVL
                     TLVGSALGLAQPLVAKQAVDASGRGQVVWPLLTLLGALFVVEAVTGAAGRFLLERMGEG
                     VVRQLRHGLVGRLLRLEMREYDRHRGGDLISRVTADTTLLREVVSQALVDLVTGSLVAA
                     GAIALMAWLDPLLLLLVAVTVAAAAVVVASLLTGIRNASEHMQGAVGAVAADMERALSA
                     LPMVRVHRAEEREVAGIGARVDAAYGAGVRTAKLASVMSSAVELAVQGSFLIVLVVGGL
                     RVGGRAGSLGDLVAFLLYASYLVLPLSSVFRAMGLVQRGMGAYQRIDEALRLPVEPAAP
                     RNPADHPPARRPTGPSGTREPPVLALRDVHFGYAPERPVLRGVSFTVPQRRHVALVGRS
                     GAGKSTVFALIARFYEPDAGTLLFDGRPATELTRDACRRRIAVVDQNTHVVHGTLRENI
                     AYAVPDATDAEIREVVELARLEEVVDRLPGGLSAVIGERGSNLSGGERQRVALARALLA
                     RPSLLLLDEPTSHLDAINESALTTVMKDIAQECALLVIAHRLSTVQHADHVVVLQDGRT
                     AAGGRHEELLAGNALYRDLAAGQMLRSGGSRGSASGRGRTVEAPRSRPGRP"
     gene            complement(10001..10438)
                     /locus_tag="K6K39_RS30975"
                     /old_locus_tag="EASAB2608_06339"
     CDS             complement(10001..10438)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988507.1"
                     /locus_tag="K6K39_RS30975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06339"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_094372599.1"
                     /sec_met_domain="PF13471 (E-value: 1.8e-25, bitscore: 88.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPAGVPLTRRLTARLVLLPALAVALLPPRHIRTVLGV
                     LRRGAAPATEAQARKARDAMCAASLRCAGPKGCLPRSLGAALLCRLGGTWPTWCTGVRV
                     TPPFTAHAWIEAEGRPVGEGVPHHYFARLVAVEPLPRPTGR"
     gene            complement(10435..10689)
                     /locus_tag="K6K39_RS30980"
                     /old_locus_tag="EASAB2608_06340"
     CDS             complement(10435..10689)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988506.1"
                     /locus_tag="K6K39_RS30980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06340"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_059254636.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 5.1e-06,
                     bitscore: 25.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.6e-23,
                     bitscore: 81.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-14, bitscore: 51.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLRLGDNVSTAETDYGTVLLDEQAGTYWELNPTAALVVRTLLNG
                     GKEADAAAALVREFDIGQAEALQDVEALVRKLRDSGLAS"
     aSDomain        complement(10441..10683)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K6K39_RS30980_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.60E-26"
                     /identifier="RREFam002.1"
                     /label="K6K39_RS30980"
                     /locus_tag="K6K39_RS30980"
                     /protein_end="83"
                     /protein_start="2"
                     /score="81.4"
                     /tool="antismash"
                     /translation="LRLGDNVSTAETDYGTVLLDEQAGTYWELNPTAALVVRTLLNGGK
                     EADAAAALVREFDIGQAEALQDVEALVRKLRDSGLA"
     aSDomain        complement(10528..10689)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K6K39_RS30980_Lasso_Fused_RRE.1"
                     /evalue="1.80E-08"
                     /identifier="RREFam003.1"
                     /label="K6K39_RS30980"
                     /locus_tag="K6K39_RS30980"
                     /protein_end="54"
                     /protein_start="0"
                     /score="25.4"
                     /tool="antismash"
                     /translation="MPLRLGDNVSTAETDYGTVLLDEQAGTYWELNPTAALVVRTLLNG
                     GKEADAAAA"
     gene            complement(10728..12578)
                     /locus_tag="K6K39_RS30985"
                     /old_locus_tag="EASAB2608_06341"
     CDS             complement(10728..12578)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988505.1"
                     /locus_tag="K6K39_RS30985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06341"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_221335148.1"
                     /sec_met_domain="Asn_synthase (E-value: 8.2e-46, bitscore:
                     156.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELHGSAGTGPGDAHFAVFTDRADAAAAARSFTRPGSRTLAHAS
                     GRPWLVGHWHDDEIVTARAGGASLAVVGCCPVDAGELRRRAARLRDLAELDALARSLPG
                     SFHLVGALDGQIRVQGTASGLRLVFHAELDGVRVAATRADTLAAVLGLEPDVEELAVRL
                     LWPAPYPLFETSMWRAVTAVPPQAAVVVAADGRTVRHTRWWTPPEPVLPLAAAAPLIRT
                     ALEEAVGARTRQGGVVSCDLSGGLDSTSVCFLADRSPARVVASTWPGRDPADTDLAWAE
                     RAMGYLPDVEHVVWDADASPLVYEDLLGIDDLLDEPTIGVMDRSRVLHHLPGLAARGSR
                     LHLTGIGGDHVAWCSEAYYHRLLRTRPLFALRQLRGFRALWQWPLGGTLRALADGRPYR
                     KWLADAAADLRGPLPPSVTTGLGWGMAPRLFDWMTPEAERMARRALLDAAATASPLHPD
                     RGLHTDLEQIRSCTRVIRQWDRMAARAGLPMASPFLDDRVIEACLAVRPGERVTPWRYK
                     PVLSAAMRGIVPEPCLRRSNKATASMDASNGLREHRADLLALWEDSQLAKLGLVDGARL
                     RRLARRPASPGLSDAILYSTIAAEVWLRGLARGRARVPQP"
     gene            complement(12605..12718)
                     /locus_tag="K6K39_RS30990"
     CDS             complement(12605..12718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="K6K39_RS30990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_223283712.1"
                     /transl_table=11
                     /translation="MMKKAYEAPTLVRLGTFRKETGLLQRSGNDRLILSKN"
     misc_feature    complement(12887..12901)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.84"
                     /tool="antismash"
     gene            complement(13178..14203)
                     /locus_tag="K6K39_RS30995"
                     /old_locus_tag="EASAB2608_06342"
     CDS             complement(13178..14203)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013088.5"
                     /locus_tag="K6K39_RS30995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06342"
                     /product="DMT family transporter"
                     /protein_id="WP_189396982.1"
                     /transl_table=11
                     /translation="MVATAAAGLLRPPVLPGCGQGGRPLSGAARRTGAGVALALLSACC
                     FGTGGAATKVLGEAGLTPVQISQARLSLAGVPLLAVALIRSPRGLRVAPRDWPVLAALG
                     AGSFAGVQTLCAISVARIPVGVYVVLQFLAPVIVVVWLRLLRGVRQPAPVWLGTALVVT
                     GLLLVGQVWSGLRLDGVGVLTALGAAVALSLRFLLAGRALARRDATAVTALGVSAGAVV
                     VDLARPVGAFPYRRLGAPARVGEVTVVPVWAVLLWTAVVSTLLACLCALAAQRFLAPAT
                     ASVLSTVEVVAGSGTGLLLLGERVTAVQGAGIGAVLVGAALAQLRAGPTRTARARWRRA
                     A"
     gene            complement(14128..15459)
                     /locus_tag="K6K39_RS31000"
                     /old_locus_tag="EASAB2608_06343"
     CDS             complement(14128..15459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009086401.1"
                     /locus_tag="K6K39_RS31000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06343"
                     /product="KamA family radical SAM protein"
                     /protein_id="WP_221335149.1"
                     /transl_table=11
                     /translation="MSAVHTVAPSPVGTRTLSGRRLAALVRERCGDEQLAHDVDVVARI
                     LPFKVSGHVVDELIDWSRAPDDPLYRLVFPHRDMVTPDQYTAVERALASPGALRAAVAE
                     VRRQLNPHPGDQLTRNVPHGPDGSPVDGLQHKYARTVLVFPRQGQTCHSYCAYCFRWAQ
                     FVGEPDLRMADDGPAAMTAYLRRHPEVTDVLFTGGDPLVMRAEMLRPYVDALLAPGLEH
                     VVTVRIGTKAPLFHPARLTAAPDAPALLRLLERVVAAGRHLAVMLHISHPRELAPDTTR
                     AALAALRGTGAQLRSQAPVIRHVNDSAETWAESWRAQVALGVHPYYLFVERDTGAQRYF
                     GLPLHRAYEIHRDAVEALSGLGRTARGPVMSTTEGKVIIDGVTELPGGERAFALRYLQA
                     RESGLVGRPFHAHWDAQAQWWSQLRPLGSYDRRFFPGADREGGP"
     gene            complement(15456..16193)
                     /locus_tag="K6K39_RS31005"
                     /old_locus_tag="EASAB2608_06344"
     CDS             complement(15456..16193)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (32-242). E-value: 1.7e-21. Score:
                     69.1. Matches aSDomain:
                     nrpspksdomains_K6K39_RS31005_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.5"
                     /locus_tag="K6K39_RS31005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06344"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_202430395.1"
                     /sec_met_domain="TauD (E-value: 2.3e-19, bitscore: 69.1,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHPAAGRLASGPDRLEQDGYVVVERLGGQRHAIELLQRIGRF
                     LPQYTGTVEHEVVHRPGHEGRAYSQSRNTIQAHTEAPGWDPSPRYLALYCHRQARCGGG
                     HTDLLDLHTLLELLGAEDRALLTGTAVAFPGPDADREGHRPVTVPMLSYDGKRPVLRFS
                     YNLLTAADYDAPLDAAPPPEHLPLGQRGIDLAHRVGELFARHRTRVLVPDGALLIWDNQ
                     RMLHARSQYADERRHLTRYWIAA"
     aSDomain        complement(15468..16097)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS31005_TauD.1"
                     /evalue="1.70E-21"
                     /label="K6K39_RS31005_TauD.1"
                     /locus_tag="K6K39_RS31005"
                     /protein_end="242"
                     /protein_start="32"
                     /score="69.1"
                     /tool="antismash"
                     /translation="RHAIELLQRIGRFLPQYTGTVEHEVVHRPGHEGRAYSQSRNTIQA
                     HTEAPGWDPSPRYLALYCHRQARCGGGHTDLLDLHTLLELLGAEDRALLTGTAVAFPGP
                     DADREGHRPVTVPMLSYDGKRPVLRFSYNLLTAADYDAPLDAAPPPEHLPLGQRGIDLA
                     HRVGELFARHRTRVLVPDGALLIWDNQRMLHARSQYADERRHLTRYW"
     misc_feature    16585..16598
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(16595..17632)
                     /locus_tag="K6K39_RS31010"
                     /old_locus_tag="EASAB2608_06345"
     CDS             complement(16595..17632)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003711.1"
                     /locus_tag="K6K39_RS31010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06345"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_059254640.1"
                     /transl_table=11
                     /translation="MLIGEVARRSGVSTRMLRHYDALGLVRPTGRTVGGYREYSAEDVR
                     RIFHVESLRSLGLSLKQIGRALEDPAFTPSALISDLVRWTEDRLARERELLERLRAIDA
                     SAPTDWQGVLRIVALMRELDSTSAARRQQAVLARSEEVPVPAELLAGAALTESDPHVAG
                     ALRWALARAGGDGVAALVAGARSEDVAVRRRAVLAIAGMPGAPGAAAALADALGDPDTT
                     VRGHAALALGRQGVAGAVPALVGMVVEGSHDVDAAEVLGTLSQDPGCADRITTALVDEL
                     AAPTADSATRIRLVQALVELAGSTVREVLRQLAHDDDHAVARVASALVGVLERRSPGDR
                     ADEDA"
     gene            complement(17626..18405)
                     /locus_tag="K6K39_RS31015"
                     /old_locus_tag="EASAB2608_06346"
     CDS             complement(17626..18405)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457515.1"
                     /locus_tag="K6K39_RS31015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06346"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_399009996.1"
                     /transl_table=11
                     /translation="MVAINTTHVTPQNARVAGALGAEDSSVRLQAALAVGSNPDPAFLE
                     TLVERCAVEPDFFVRDMLSWALTRLSPEVALPRIRRELGSERPQARSQALHTLSKVGDR
                     STWAWITRDMLRDADDEVARTAWRVAVALVPEDEENELADELVRQLGRGDRSVQLSLSR
                     ALVDLGDVTRPALEKAAANPDPAVAAHARATELLRQNPQTGFDAAVEEARRVVALGPER
                     AAAASAAPADAEPTQTTGTAETTGAARDAETSEAPHC"
     gene            18561..18929
                     /locus_tag="K6K39_RS31020"
                     /old_locus_tag="EASAB2608_06347"
     CDS             18561..18929
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027002.1"
                     /locus_tag="K6K39_RS31020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06347"
                     /product="VOC family protein"
                     /protein_id="WP_086702746.1"
                     /transl_table=11
                     /translation="MSTIQPVILTADQDALLDFYTTLFGAEQIFRIPEEGPAFYLGLRI
                     GDTDLGLVAKPDAGTGAAPRVLLSIGVDDVDETLGRVEALGGSVRSGPNDMPWGQRVAH
                     ILDPDGNPLNLTQPIPAR"
     gene            complement(19170..19715)
                     /locus_tag="K6K39_RS31025"
                     /old_locus_tag="EASAB2608_06348"
     CDS             complement(19170..19715)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS31025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_06348"
                     /product="hypothetical protein"
                     /protein_id="WP_059254643.1"
                     /transl_table=11
                     /translation="MPFIRHRVSAVIAAVLLCLAGAVISLQNSTTASAQGPDGGVQHMQ
                     QSRVDLQPTPSGRWVNVPLAVTLPRPGTYLLDADVRGRIAGDGNDRLLASIQARLWDAT
                     DGAVVPQSERLVTHMNNPPLSGTIARQSTAPISERITVTRETVIRLQVRRVDSVGQSYR
                     ADIFSDGSGRTSLRYQRV"
     gene            complement(19887..20321)
                     /locus_tag="K6K39_RS31030"
                     /old_locus_tag="EASAB2608_06349"
     CDS             complement(19887..20321)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358622.1"
                     /locus_tag="K6K39_RS31030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06349"
                     /product="adenylyltransferase/cytidyltransferase family
                     protein"
                     /protein_id="WP_059254644.1"
                     /sec_met_domain="CTP_transf_like (E-value: 3.2e-21,
                     bitscore: 74.9, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGETLGYAPGVFDLFHVGHLNILRQAREHCDRLVAGVCSDDLVVR
                     LKNQPPVVPLSERLEIVRSVRYVDDVFVATVEDKLEIWKEVGFDVIFKGDDWLGTELWQ
                     NLEAEFARRGVKVVFFPYTVHTSSTLIRSALDVLAQRAGP"
     misc_feature    complement(20157..20159)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20321..21853)
                     /locus_tag="K6K39_RS31035"
                     /old_locus_tag="EASAB2608_06350"
     CDS             complement(20321..21853)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669252.1"
                     /locus_tag="K6K39_RS31035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_06350"
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_221335150.1"
                     /transl_table=11
                     /translation="MLRKSTTRTVTTACAVALLAAASLTTAVGAQARGPELLTAAPLAT
                     WQTNGIVWTVEYARGVVYVGGTFDRVRPPGAKPGEKETARKNFAAFDAATGRLLPCAHS
                     FTRGAATVRALKASPDGKVLYVGGSFGRVDGGGVASAVALDTATCSVRRDFRPAVTATV
                     RAIETTGSTVYLGGDFTVVNGKPRKHLASFTRKGRLLPFRADIDGPVRAVLAAPDHGKV
                     LVGGDFQNVNGRTERALVAVHPQTGSTVTSFPEWLPPRASVKSLARGGTRFYLGAEGRG
                     TGIFDGRIAGRLSDGTMLWKDFCLGATQAVVVHGNVLYSASHSHYCGRTPGGFPDGPRR
                     NFLAQSVDDKRLLHWFPDTNDGLGEGVGPRTLVMAGTTLWAGGEFTTVNGRAQQSLTRF
                     GTGPRNKAPEAAPRLSGKSSRAGKVTLTWRAAWDRDDAELTYLIYRDGRLVASPKQRSV
                     EWHRPEMRYTDSVARGSRHRYAIAVTDGKNTTPRSKPLQVTAVAGKRPTGAR"
     misc_feature    complement(21906..21920)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.42"
                     /tool="antismash"
     misc_feature    complement(22169..22185)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
ORIGIN
        1 ccggtatctg cggcaccgac ctgcacatcc gggcctggga cggctgggcc cagcaggcca
       61 tccgcacgcc cctcgtggtc ggccacgagt tcgtgggaca ggtcgtcgag gtcggccggg
      121 acgtgaccga catccgcatc ggcgaccggg tcagcggcga gggccacctg gtgtgcggca
      181 agtgccgcaa ctgcctggcc ggccgccgcc acctgtgccg cgccaccgtc ggcctcggcg
      241 tcggccgcga cggcgccttc gccgagtacg tcgcgctgcc cgcgtccaac gtctgggtgc
      301 accgcgtccc cgtcgacctc gacgtcgccg cgatcttcga cccgttcggc aacgccgtgc
      361 acaccgcgct ctccttcccg ctggtcggcg aggacgtcct gatcaccggc gcgggcccga
      421 tcggcctgat ggccgccgcc gtggcccggc acgccggcgc ccgcaacgtg gtcgtcaccg
      481 acgtcagcga ggagcgcctg gacatcgccc gcaagatagg ggtgagcctc gccctgaacg
      541 tcgcggagtc caccatcgcc gacggacagc gcgaactggg actgcgcgag ggcttcgaca
      601 tcggcctgga gatgtccggc cgccccgagg ccatgcggga catgatcgcc aacatgacgc
      661 acggcggccg gatcgccatg ctcggcctgc ccgccgagga gttcccggtc gactgggccc
      721 ggatcgtcac ctcgatgatc accatcaagg gcatctacgg ccgcgagatg ttcgagacct
      781 ggtacgcgat gtcggtgctg ctggagggcg gcctggacct cgcccccgtg atcaccggcc
      841 gctacggcta ccgcgactac gaggcggcct tcgcggacgc ggcgagcggc aagggcggca
      901 aggtcatcct ggactggacc gcgtaacccg cagcacgcgc accctccctc accccgtcag
      961 aaccttcagg agcccccatg ttcgacaccg tccgcgacga cctgcgcgcc accctcgacg
     1021 agatccgcgc cgccggcctg cacaagcccg agcgggtcat cgacaccccg cagtccgcga
     1081 ccgtgaacgt caccgccggc ggccgtcccg gcgaggtcct caacttctgc gccaacaact
     1141 acctcggcct cgccgaccac cccgaggtga tcgccgccgc ccaccaggcc ctggaccgct
     1201 ggggctacgg catggcctcc gtgcgcttca tctgcggcac ccaggaggtg cacaaggagc
     1261 tggaggcccg gctgtcggcc ttcctcggcc aggaggacac catcctgtac tcctcctgct
     1321 tcgacgccaa cggcggtgtc ttcgagaccc tcctcggcga ggaggacgcg gtgatctccg
     1381 acgccctcaa ccacgcctcc atcatcgacg gcatccggct gtccaaggcc cgccgcttcc
     1441 gctacgccaa ccgcgacctc gcggacctgg aggcgaggct gaaggaggcg tccgacgcgc
     1501 gccgccggct gatcgtcacc gacggcgtct tctccatgga cggctacgtg gcgccgctga
     1561 gcgagatctg cgacctcgcc gaccgctacg acgccatggt catggtggac gactcgcacg
     1621 ccgtcggctt cgtcggcccg accggccggg gcacgcccga gctgcacggt gtcatggacc
     1681 gggtcgacat catcaccggc accctcggca aggccctcgg cggcgcctcc ggcggctacg
     1741 tcgccgcccg cgccgagatc gtcgccctgc tgcgccagcg ctcccgcccc tacctgttct
     1801 ccaacaccct cgccccggtg atcgccgccg cctccctgaa ggtcctcgac ctgctggagt
     1861 ccgccgacga cctgcgggtc cggctcgccg agaacaccaa gctgttccgc agccggatga
     1921 ccgaggcggg cttcgacgtc ctccccggcg accacgccat cgcccccgtc atgatcggcg
     1981 acgccgccga ggcggcccgc atggccgaac tgctgctgga gcgcggggtc tacgtgatcg
     2041 gtttctccta cccggtcgtc ccgcagggcc aggcccgcat ccgggtccag ctgtccgccg
     2101 cgcactcgac ggacgacgtc aaccgcgctg tcgacgcgtt catcgcggcg cgcgccgagc
     2161 tggcggtctg accagggcgg acgaccgggg ataattgagg tcatgatcga ggcacggcgg
     2221 ctccacatcc tccgtgcggt ggccgaccac cgcacggtca cggcggcagc cgccgcgctg
     2281 tacctcaccc cctccgccgt ctcccagcag ctgacggctc tggagcagga gaccggccac
     2341 cgcctggtcg agcgcggcgc caagggcgta cggctcaccc cggcaggcga gatcctgctc
     2401 agccacacca atgccgtcct cgcccagctg gagcgggccg aggccgagct ggccgcctac
     2461 ggctcgggcg aggcgggcac ggtcaccgtg gcggccttcg cgaccggtat cgcccaggtc
     2521 gtggccccgg ccgtggcccg cctcgccggg tccgcccccg gcataaagat ccgggtccag
     2581 gacgcggagg gcgacgccag cctgcccatg gtgctggacc ggcaggtcga tgtcgcggtc
     2641 gccgtcgagt accggggcgc gccgtccgcc gacgaccccc gcctgaccca cgtgccgctc
     2701 tacgccgagc cgttcgacgc cgtcgtgccg gtggggcacc gcctggcgga cgcccccgag
     2761 gtgcccctcg ccgaactggc caaggacccg tggatcggcc cgtaccccgg caacccctgc
     2821 cacgacgtgg tggtgctcgc ctgcgagagc gccggcttcc agccccgcct cgaacactcc
     2881 tccgacgact tccgcgccgt cgtcgccctc gcctcggccg acgccggggt ggcgctcgta
     2941 ccgcgttccg cgctgcgcgg catggacctc acgggtgtgg tcgtacgccc cgtcgacggc
     3001 gtggccccga cccggcgggt cttcgccgcc gtccgccgtg gcgccgaggg gcacccgctg
     3061 atccgcccgg tgctgacggc gctcggcgag gccgcccagg cgtgaggctt ctgtaacctc
     3121 gccgtctcat gtccgggata gcgtcccgca tatgagaagc gaggaacccg tcgatctcct
     3181 cctcggcgcc cggctggccg aactgcgcgc ccagcacggc tggtccctgg gcgagctggc
     3241 ggagcgcagc ggagtcagcc ggtccaccct gtcccgcgcc gagcgcgccg agaccagccc
     3301 caccgccgcc cagctgaacc ggctctgcca tgtctacggc cgcaccatgt cgcagctgct
     3361 cagcgaggtc gaggcggcac cggttccgct ggtccgggcc gccgagcagc aggtgtggga
     3421 ggaccgcgcc tccggcttcg tccgccggtc cgtgtccccg ccgcacagcg gactgcgcgg
     3481 cgaactggtc gagggccggc tcacccccgg cgcggacctc gcctacgacc gcccgcccgt
     3541 gcccggcctc gaacagcacc tgtggctgct ggcgggagcc ctggaggtga cggccgggga
     3601 gcggacccac cggctcgacg cgggcgactg cctgcggatg cgcgtcaccg gtgcgacccg
     3661 cttccgctgc cccggtccga ccgaggcacg ctacgtcctg gcggtggtcc ggccatgagg
     3721 gtggagcact ggaccggcgc ccaggtgcac gaccgggccg acgacctggc ggcgctgctg
     3781 accgacaccg tggccgcggg cgcctccgtc ggcttcctcg cgccgctcgg gcacgcggag
     3841 gcggtcgcct ggtggcggga gcgggcggcg gccacggcgg cgggccgact cgccgtctgg
     3901 acggccctgg accccgcgga ccgggtcacc ggcacggtcg gcctggcctt ccccgacaag
     3961 ccgaacagcg ggcaccgcgc cgagctggtc aagctgatgg tgcaccgctc ggcccggggc
     4021 cggggcctcg gccgccttct cctcaccacc gccgaacggg ccgccgctgc cgccggccgc
     4081 accctgctcc acctcgacac cgagaccggc agccccgccg agcagctgta ccgctcggcc
     4141 ggctggaccg aggccggcac catccccgac tacgcggcga gcccggcggg cgagttgcgg
     4201 ccgacgacgc tgtactacaa gcggctcgga ggctgattgt cagtggtggg ggctaccgtg
     4261 cgagacatgc cggatgcaga agccgtacgc cgaatcgccc tgtccctgcc ggacaccacg
     4321 gagaagatcg cctggagcat gcccacgttc cgggtcgccg ggaagatgtt cgcgaccctg
     4381 cccgaggacg agacgtccat cgccgtgcgc tgccccaagg tggagcgtga cgaactggtg
     4441 ctggccgagc cggagaagtt ctggatcgcc gaccacgagg cccagttcgc ctgggtgaga
     4501 gcgagactcg ccgccctgga ggacgaggag gagctgcggg acatcctggc cgactcctgg
     4561 cgccaggccg ccccgacccg actcctcgac gcccaccccg agttggggct cccgcccggg
     4621 gcctgaaaac cccggcggag gcgcggccgg gggtggcatg atcccgcgcg tcggcaggca
     4681 gggcggccac cggccggtga cggccgcccg ggggagggga gcactcggca tgaccggaac
     4741 ggacgcgcgg cgcgacaccg ccgcccgggg tgtgcgcagg gcggcggccg gttccccggc
     4801 ggtctggtcg cgggacttcg ccctgttctt cgcggcccgg gccgtcgccc gcctcggcga
     4861 caccatgctg cccgtcgccc tcgcggccgg cctgctggag cacgggtacg gcgcgggcgc
     4921 ggtcggcctc gccatggcct ccacggccgc cgcgttcgcc gggctggtcg tcttcggcgg
     4981 ggtcgtcgcc gaccggttca gcacccgcaa gctgatgatc ggcgccgacc tggtccggct
     5041 cggcgcccag gctctcgccg cggggctgtt cttcaccggg cacgtggtgc tgtggcagat
     5101 ctgcgccatc ggcttcgtca acggcgtggc cggcgcggtc ttccagccgg gcgtggccag
     5161 cactgtgccc cggctggccg ccgacgtcca gggcgccaac ggtgccatcc ggatcgccga
     5221 gtccgccgcc cagctcgccg gccccgccgt cgccggcgtc ctggtcggcc tggcctcgcc
     5281 cggcggtgtc ttcgccgcgc acgccaccac gtacgcgctc agcgccctgt gcctgctgct
     5341 gctccggctg cccccgctcc ccgccggccc ccgggccgcg agcggctccg cgctgcgtgc
     5401 cttccgcgcc gatctggccg acggctggcg ggagttccgc tcccgggcgt ggctgtgggg
     5461 cgtgatcgcc gtctggtgcc tctacatgat cgccgtctgg ggccccaccg tcccgctggt
     5521 ggcgaccgag gtcgttcggc accacggccc gggcgcctac ggcctggtca actcggccct
     5581 cggcgtgggc acggtgatcg gcggcctgct cgccctgcgg ctgcgccccc gccggatgct
     5641 ccgcgcgggc gcgttctccc tgttcgcctt cttcggcttc ccggcggccg tcggggcggg
     5701 cctcggggtg ccggccatgg cggccggggc ggcgctcgcc ggtgccggga tgtcgttctg
     5761 gggcgtgatg tgggcgacga ccgtgcagac gcaggtcccg gccgacgtcc tgaaccgtat
     5821 ccacgcctac gacgtggccg gctccctcgc catgatgccg gtcggccagg ccctcgtcgg
     5881 cccggcggcc ggagtgctgg gcgccggcca cgtcctgctg accgcgggcg cggtgagcct
     5941 gctcgtggcc gcgatcctgc tcgccgtccc accgatacgc gacctgcccc gagccgacac
     6001 ccctgccccg acggcccact gaaccccggg cctcacgtgc ccgacgcccg ctgaacctcc
     6061 ggcctcaccc gcccggcgcc cacggatccg tcggcctgcc cagcgcccct gagcccgggc
     6121 cggacccccg ccgtcgccca cccgcacccc gcagcccgct gagcgcgccc ggcctcaccc
     6181 gcgcccggcc gccacccgcc ccgcgcccac gaaccggtcg atccgctcgc gcaggctcgc
     6241 ggcgtccagg ccgtgcgcgg ccacatgctc ctcgatcgtg ccgtagcggc gcagctcacg
     6301 gcgtccgacg ccgaggccga gcacccggtg cggcacatcg gccagggcct cgctcaccgc
     6361 ggccgtcgag gtccccgcca ggtacggctc gaccagcacg acgtccgtac ccgccgcctc
     6421 cgtcgcccgg cgcaacccgg ccgcgtcgaa gggtcgtacg gtcgtcgcgt acagcacggt
     6481 cacgtccagg ccctccgtgg cggcgaggac cgcgtccagc accggcccga cggcgacgac
     6541 cacgccgccg cggccctcgc ggaccgtgct gaagtgccgc ccgtcgatca cccggccctg
     6601 ccggttggac tgcacggaca gccgcacgta caccttgtcg tcacccgcgg cgaccgcgtg
     6661 gtgcagcagc gtctcggcct cgtccggatg ccccggcaca tgcacggtcc acccgtccag
     6721 cgtgtcgagc agggccacgt cacccggggc catgtgcgtg aagccgccgg ccggccagtc
     6781 gaaggaggcg gcggcgctca ccagcaccgc gcccgcgtcc tggtgcccca gatccagctt
     6841 gagctgctcg aacggccgct ccacgaggaa gctggcgaag gtgtggacga ccggccgcag
     6901 cccggtcagc gcgagccccg ccgccgcccc gaccagcagc tgctcgcgga tgccgacgtt
     6961 gatcacccgg tcggggtgcc ggcgcatggc gtcccggaag ccgtcgacac cgatctcggc
     7021 gaggacgacg gcgacccgcg ggtcctcgtc cagcagccgg gagacgacgg gggcgaaacg
     7081 gtcacgcatg gtgtccatga gggtgtgccc tttctctgag cgcgggggag ggtcaggcgt
     7141 tcttcggctc gacgcgggcc acgaccacgt gcggccggcc cggatgcggc gcggtgaacg
     7201 cggcgtacag ggcctcgtgg tcgcgtccgt cgacggtcac cgcggaccag cccgcggcct
     7261 cgaaccgggc ggcgatcccg ccgggcagcg catgactggc ggaggagttg tcgatcacga
     7321 cggtgtgcag ccggtcgagt ccggcgggcc cggcgaaggc gatcgcctcg tggttgctgc
     7381 cctcgtccag ctcggcgtcc ccgatcagca cccacaccgc cgggtcgggc cggccctgcg
     7441 cccgcaggcc cagcgcggtg cccacggcga tcggcagccc gtgcccgagc gacccgctgc
     7501 cgatctcggc gcccggcacc agtacccggt ccgggtgatg cccgagcggg gagtcgtacg
     7561 acccgaagcc cggcagccag tccaccggca cgaagccctt cgccgcgagc acggcgtagt
     7621 acgccatggg cccgtgcccc ttgctcagca ggaaccggtc ccgggccggg tcgtcccgcc
     7681 gctccggacc gacccggagc acccggtcgt acagcaccca cagcacgtcg agcgtggagg
     7741 tggccgccgg gccgtgcttc tcgtcgccgg tcatcagccc catcagccgg ggcaggtcgt
     7801 catagccgta cgtgcggctc tgttccgctg tggtcgtcat gccgacgatc gtgcaacctc
     7861 aaccaaactt caggtcaaga agaaaaagga gcgcgcgacc accgatccga gtgcggtatt
     7921 gtttccctgc gcgttcggcc ggggaaagcc caggtcaaac ggcaacggga cgtggcgcag
     7981 cttggtagcg cacttgactg ggggtcaagg ggtcgcaggt tcaaatcctg tcgtcccgac
     8041 ttgtgagagt cgcaggtcag ggccggtttc ggaagcatcc gaaaccggcc cttgatcatt
     8101 tctgcggctc ggccgggcca ctacggccgg cccggccgcg agcggggcgc ctcaaccgtt
     8161 cgtccgcgcc cgctcgccga tccccggctc ccgcccgacc ggagcatctg gccggcggcc
     8221 aggtcgcgat agagggcatt gccggccagc aactcctcgt ggcgtccgcc ggcggccgtg
     8281 cggccgtcct ggagcaccac gacatggtcg gcgtgctgca cggtggacag acggtgcgcg
     8341 atgaccagca gcgcgcattc ctgggcgatg tccttcatga cggtggtgag cgccgattcg
     8401 ttgatcgcgt cgaggtggga ggtgggctcg tccaggagga gcagcgaggg gcgggccagc
     8461 agggcgcggg cgagggcgac acgttgccgt tcgccgccgg agaggttgct gccgcgttca
     8521 ccgatgacgg cggacaggcc cccgggcagc cggtcgacga cctcttcgag gcgggccagt
     8581 tcgacgacct cccggatctc cgcgtcggtg gcgtcgggca cggcgtaggc gatgttctcg
     8641 cgcaacgtgc cgtggacgac atgggtgttc tggtcgacca cggcgatgcg ccggcggcag
     8701 gcgtcacgag tcagctcggt cgcgggccgc ccgtcgaaca gcaaggtgcc cgcatccggc
     8761 tcgtagaacc tcgcgatcag ggcgaacacc gtgctcttgc cggcgccgga ccggcccacc
     8821 agggccacgt gccggcgctg cgggacagtg aacgagacac cgcggaggac cggccgctcg
     8881 ggggcgtagc cgaagtggac gtcgcgcagg gcgaggacgg gcggttcgcg ggtgccggac
     8941 ggtccggtcg gccgccgtgc gggcgggtgg tccgccgggt tccggggcgc ggcgggttcc
     9001 accggaaggc ggagtgcctc gtcgatgcgc tgataggcgc ccatgccgcg ttggacgagg
     9061 cccatggcgc ggaagacgga ggacagcggc aggacgaggt acgaggcgta caggaggaac
     9121 gcgacgaggt caccgagcga gccggcccgg ccgccgacgc gcaggccgcc gacgaccagg
     9181 acgatgagga aggaaccctg gacggcgagt tcgacggcgg agctcatcac ggaggcgagc
     9241 ttcgcggtgc gcacccccgc gccgtaggcc gcatccacgc gggcgccgat gccggccacc
     9301 tcgcgctcct cggcgcggtg cacccggacc atcggcaggg cgctcaaagc gcgttccatg
     9361 tcggcggcga cggcaccgac cgcgccctgc atgtgttcgg acgcgttcct gatgcccgtg
     9421 agcagcgagg cgaccaccac ggccgccgct gccacggtca cggcgaccag gagcagcagc
     9481 agcgggtcca gccacgccat gagggcgatc gccccggcgg cgaccaggct tcccgtcacg
     9541 aggtcgacca gggcctgcga gacgacctcc cgcagcaagg tggtgtcggc cgtcacccgg
     9601 gagatgaggt cgccgccccg gtggcggtcg tattccctca tctccagccg gagcagccgg
     9661 cccaccagcc cgtgccggag ctgccgtacg acgccttcgc ccatccgttc cagaaggaag
     9721 cgtcccgctg cgcccgtcac cgcctcgacc acgaacagcg cgcccaagag cgtcagcagc
     9781 ggccagacga cctgtccgcg gccgctcgcg tccacggcct gcttggcgac gagtggctga
     9841 gccagtccca gggccgaccc caccagggtc aggacgacgg cgacggcgat ggcgccccgg
     9901 tgcccggcgg tgagccggta catcgtgacc accgccgcca gggtggacct gccggatccg
     9961 gcggcatcgg cccggccgcc gtgcgggacc gtcgcgccgg tcatcggccg gtgggccgtg
    10021 ggagcggttc gaccgccacc agccgggcga agtagtggtg cgggacgccc tcgccgacgg
    10081 gacggccctc ggcctcgatc caggcgtgcg cggtgaaggg cggggtgacc cgtacaccgg
    10141 tgcaccaggt gggccatgtg ccgccgagcc ggcacagcag cgccgctccc agggagcgcg
    10201 gcaggcatcc ctttggtccg gcgcagcgca ggctggcggc gcacatggcg tcgcgcgcct
    10261 tgcgggcctg tgcctcggtc gccggcgcgg cgccgcgccg caggacgccg agcacggtgc
    10321 ggatgtggcg gggcggcagc agggcgacgg cgagggccgg gagcaggacg agacgggcgg
    10381 tcaggcgtcg ggtcagaggc acaccggcag gccgctccag ggcgctgggc gtcgtcatga
    10441 ggcgagcccc gagtcgcgca gcttccgtac cagcgcctcg acgtcctgca gggcctcggc
    10501 ctggccgatg tcgaactccc ggaccagggc ggcggccgcg tccgcctcct tgccgccgtt
    10561 cagcagcgtc cgcaccacca aggcggctgt cgggttcaac tcccaatagg taccggcctg
    10621 ttcgtccagc agcacggtgc cgtagtcggt ctcggccgtg gagacgttgt cgccgaggcg
    10681 caggggcatg tgaggggcct ttctggcgtg ttcgacaggg gatgcggtca gggctgcggg
    10741 acacgggcgc ggccgcgggc cagcccgcgc agccacacct ccgcggcgat cgtggagtag
    10801 aggatggcgt cggagagccc cggggaggcg ggccgccggg cgaggcggcg caggcgggcg
    10861 ccgtccacca ggcccagctt cgccagctgc gagtcctccc acagggccag caggtcggcg
    10921 cggtgttcac gcagtccgtt ggaggcgtcc atggaggccg tggccttgtt gctccggcgc
    10981 aggcacggct cgggcacgat gccgcgcatc gcggcactga ggacgggctt gtaccgccag
    11041 ggcgtgacgc gctcgccggg gcgtacggcg aggcacgcct cgatgacgcg gtcgtcgagg
    11101 aacggagagg ccatcggcag gccggcgcgg gccgccatcc ggtcccactg ccggatgacg
    11161 cgggtgcacg agcggatctg ttcgaggtcg gtgtggagtc cgcggtccgg atgcagggga
    11221 gaggccgtcg cggcggcatc gagcagcgcc cggcgggcca tccgctcggc ctcgggagtc
    11281 atccagtcga acaggcgcgg ggccatgccc cagccgagac cggtcgtgac cgacggaggc
    11341 aacgggccac gcaggtcggc ggcggcgtcg gcgagccact tccggtacgg ccggccgtcg
    11401 gcgagagcgc gcagggtgcc gccgagcggc cattgccaca gcgcccggaa cccgcgcaac
    11461 tggcgcaggg cgaacagcgg acgggtgcgc agcagccggt ggtagtacgc ctcggagcac
    11521 catgccacgt ggtcgccgcc gatgccggtc agatgcaacc ggctgccacg cgcggcgagg
    11581 ccgggcagat ggtgcaggac gcgggagcgg tccatgacgc cgatggtggg ttcgtcgagc
    11641 aggtcgtcga tgccgagcag gtcctcgtag accagcggcg aggcgtcggc gtcccagacc
    11701 acgtgctcga cgtccggcaa gtaccccatc gcccgctcgg cccaggccag gtcggtgtcc
    11761 gccggatccc gtcccggcca cgtactggcc accacacggg ccggggagcg gtcggccagg
    11821 aagcagacgg aggtggagtc cagaccaccg gacaggtcgc agctcaccac gccgccctga
    11881 cgggtgcggg cgccgacggc ctcctccagt gccgtgcgga tcaggggcgc cgccgcggca
    11941 agcggcagga ccggctccgg cggtgtccac caccgcgtgt gccgtacggt ccgcccgtcc
    12001 gcggcgacga ccacggcggc ctgcggagga acggcggtga ccgcacgcca catcgacgtt
    12061 tcgaacagcg ggtacggggc gggccacagc agcctgacgg ccagttcctc cacgtcgggt
    12121 tccaggccca ggacggcggc gagcgtgtcg gcgcgggtcg cggccacgcg cacgccgtcg
    12181 agttccgcgt ggaagacgag tcgcagtccg gaggcggtgc cctgcaccct gatctgtccg
    12241 tcgagggcgc cgacgaggtg gaagctgccg gggagggagc gggccagtgc gtccagctcc
    12301 gcgagatcac gcaatcgtgc ggcccggcgc cgcagttcgc cggcgtcgac cgggcagcag
    12361 ccgacgacgg cgagggaggc gccgccggcg cgcgccgtga cgatctcgtc gtcgtgccag
    12421 tggccgacca gccagggccg gcccgacgcg tgcgcgaggg tacggcttcc ggggcgggtg
    12481 aaggagcggg ccgcggcggc cgcgtccgca cggtccgtga agaccgcgaa gtgcgcgtcg
    12541 ccggggcccg tccccgcact tccgtgcagt tcagtcatga cgtcgggtca aggaccgtcg
    12601 gtcgtcagtt cttgctcagg atcagccggt cgttgccgga gcgctggagg agccccgtct
    12661 ccttccggaa ggtaccgagc cggacgagcg tgggtgcctc gtacgccttc ttcatcatca
    12721 ctcctcagct agaggttccg cgaggcctcc ctgaccggcg gcccagggga ctggcccatg
    12781 agctgccggt cggcacaggg ctcatcggga gcccgggcca ggaagcggac gcagcaacag
    12841 ctagctgcag agcgtgagaa cggggcaaga gccccgataa agatcgcata atatgcaaaa
    12901 tctggatccc tggagttgcg cacccgctcc cggtccggtc ggagccggcg gagcgtggcc
    12961 gtgcgacctg gctgcacacg tgctcgaatg aacgttttga cgtgcgcccc ggcagctgct
    13021 cgccgcacct gccgggacgc gtccgacgac ggccgcgggc gggcgccgcc ggggcgcgct
    13081 tcctgccctt cgacgtgctc cccctcgtgt cgctccgccc tggatcgttc atcggaaacc
    13141 tcaccggcgg ggccgcgcgc ggacgacggg tgcggcccta cgccgcgcga cgccaccggg
    13201 cacgggccgt ccgcgtcggt ccggcgcgca gctgggccag agccgcgccc acgagaacgg
    13261 cgccgatgcc ggcgccctgc acggccgtca cccgctctcc gagcaacagc agccccgtcc
    13321 cgctgccggc gaccacctcc accgtggaca gcacgctcgc cgtggccggt gccaggaagc
    13381 gctgcgccgc cagcgcgcag aggcaggcca gcagtgtgga gacgacggcg gtccacaaca
    13441 gcaccgccca caccggcacc accgtcacct cgcccacccg ggccggggca cccagccgcc
    13501 ggtagggaaa ggcgccgacc ggacgcgcca ggtcgaccac caccgcgccc gcgctgacgc
    13561 cgagcgcggt cacggccgtg gcgtcgcgcc gggccagcgc ccgcccggcg agcaggaacc
    13621 gcagggacag cgcgaccgcc gcccccagag cggtgagcac cccgactccg tccagccgca
    13681 gccccgacca cacctgcccc accagcagca gccccgtcac caccagggcc gtgcccagcc
    13741 agacgggcgc cggctgccgc accccgcgca gcagccggag ccacaccacc acgatcaccg
    13801 gcgccaggaa ctgcagcacc acgtagacac cgaccgggat gcgggccacg gagatcgcgc
    13861 acagggtctg cacgcccgcg aaggaccccg ctcccagagc cgccagcacg ggccagtccc
    13921 gcggcgcgac ccgcaggccg cgcgggctcc ggatcagcgc gaccgccagc agcggcaccc
    13981 cggcgaggct gaggcgggcc tggctgatct gcaccggggt gagcccggcc tcgccgagca
    14041 ccttggtcgc cgccccgccg gtgccgaagc agcaggccga caggagggcg agcgcgacgc
    14101 ccgcgccggt ccggcgggcc gccccgctca ggggccgccc tccctgtccg cacccgggaa
    14161 gaaccggcgg tcgtaggagc ccagcggccg cagttgcgac caccactgcg cctgtgcgtc
    14221 ccagtgcgcg tggaagggcc ggcccaccag cccgctctcc cgtgcctgga ggtaacgcag
    14281 cgcgaacgcc cgttctccgc ccggcagttc cgtcaccccg tcgatgatca ccttgccctc
    14341 ggtcgtcgac atcaccggcc cgcgcgcggt gcgcccgagc ccggagagcg cctcgacggc
    14401 gtcccggtgg atctcgtagg cgcggtgcag cggcagcccg aagtagcgct gggcgccggt
    14461 gtcccgttcc acgaacaggt agtacggatg gacgcccagg gcgacctgtg cccgccagga
    14521 ctcggcccag gtctcggcgc tgtcgttcac atgccgtatc actggcgcct gcgagcgcag
    14581 ctgggcgccg gtgccgcgca gcgcggccag ggccgcccgc gtggtgtccg gggccagttc
    14641 gcgggggtgg gagatgtgca gcatcaccgc cagatgccgt cccgcggcca ccacccgttc
    14701 gaggaggcgc agcagcgccg gggcgtcggg ggcggcggtc agccgggcgg gatggaacaa
    14761 gggggccttg gtcccgatgc gcacggtgac gacgtgttcc aggccgggcg cgaggagggc
    14821 gtcgacgtac ggccggagca tctccgcgcg catgaccagc gggtcgccgc cggtgaagag
    14881 cacgtcggtg acctcgggat gacggcgcag gtacgcggtc atcgcggccg ggccgtcatc
    14941 ggccatgcgc aggtccggct cacccacgaa ctgtgcccag cggaagcagt aggcgcagta
    15001 gctgtggcag gtctgcccct gccgcgggaa gacgagcacg gtccgggcgt acttgtgctg
    15061 gaggccgtcc accggacttc cgtccggtcc gtgcggaacg ttgcgggtga gctggtcgcc
    15121 cggatgcgga ttgagctgcc gccgtacctc cgcgacggcc gcgcgcagcg cccccggcga
    15181 cgccagcgcc cgctccaccg ccgtgtactg atccggtgtc accatgtcgc ggtgcgggaa
    15241 caccagccgg tacagcggat cgtcgggcgc gcgcgaccag tcgatcagct cgtccacgac
    15301 atgcccgctg accttgaacg gcaggatccg cgcgaccacg tccacgtcgt gggcgagctg
    15361 ctcgtccccg caccgctcgc gcaccagtgc ggccaggcgc cgcccggaga gcgtgcgcgt
    15421 gcccacgggg gatggggcga cggtgtgcac cgcgctcatg cggcgatcca gtaccgggtg
    15481 aggtggcggc gttcgtccgc gtactgtgaa cgtgcgtgca gcatccgctg gttgtcccag
    15541 atcagcagtg ccccgtccgg gacgagcacc cgggtgcggt gccgggcgaa cagctcgccg
    15601 acccgatgcg cgaggtcgat gccccgctgc cccagcggca ggtgctccgg tggcggggcg
    15661 gcgtccaggg gagcgtcgta gtcggcggcc gtgagcaggt tgtagctgaa ccgcaggacg
    15721 ggccgcttcc cgtcgtacga cagcatcggc acggtcaccg gccggtggcc ctcccggtcg
    15781 gcgtccggtc cggggaaggc gacggcggtg ccggtcagca gcgccctgtc ctccgcaccg
    15841 agcagttcga gcagggtgtg caggtccagc aggtcggtgt ggccaccgcc gcagcgggcc
    15901 tggcggtggc agtacagggc caggtagcgg ggactggggt cccagccggg cgcctcggtg
    15961 tgggcctgga tggtgttgcg gctctgggaa taggcccggc cctcatggcc ggggcggtgg
    16021 acgacctcgt gctcgacggt gcccgtgtac tgcggcagga agcggccgat ccgctgcaac
    16081 aactcgatgg cgtggcgctg cccgccgagc cgttccacga cgacgtaacc gtcctgctcc
    16141 agccggtccg gaccggaggc caggcggccg gcggcagggt gtggcgctgt caaagcgtgc
    16201 ctcccttcgg catgtcaccc gtgtcggggc acgatgccgg agcacccccg tcgtccggag
    16261 cgcaccccgg caccacgcgg cccatcctcg gcggccgagg agggcggggc aacgcggggt
    16321 gaccgcttcc ggacaccggc gcacgagcgg accgccacgg ccggaatccg gcgttccacc
    16381 gcccgtgtcg aggcaggaga ccgccggcgc cgccccggtg ccccggacac caccggggac
    16441 ccccggcccg ctgaggacga ccggtctccc acgcacggtc tcggccggac ggccggaagg
    16501 ttcccccgtc accttttgcg agacctcacc tctttccagg ccgcgcaacg gggacttgac
    16561 cctcggcacc ggcacgactt ccccttgccg ccgatcaggc gtcctcgtcg gcccggtccc
    16621 cgggggaccg ccgttccagg actccgacga gggccgaggc gacgcgggcg acggcgtggt
    16681 cgtcgtcgtg ggcgagctgg cgcaggacct cccgcacggt ggatcccgcg agttcgacca
    16741 gcgcctgcac gaggcggatc cgcgttgcgg agtccgcggt gggcgcggcg agttcatcga
    16801 ccagagcggt cgtgatccgg tccgcgcacc cggggtcctg ggacagcgtt cccagcacct
    16861 ccgccgcgtc cacgtcgtgg gagccctcga ccaccatgcc gaccagtgcg ggaacggctc
    16921 cggccacgcc ctgcctgccc agggccaggg cggcgtgccc gcgtaccgtc gtgtccgggt
    16981 ccccgagggc gtccgcgagc gcggcggccg cacccggagc cccgggcatc ccggcgatcg
    17041 ccagcaccgc gcgccgccgg acggcgacgt cctccgagcg cgcgccggcg accagcgctg
    17101 ccacgccgtc accgcccgct cgggcgagcg cccagcgcag cgcgcctgcg acatgggggt
    17161 cggattcggt cagggccgcc ccggccagca gctcggcggg aaccggcacc tcctccgacc
    17221 gggccaggac ggcctgctgt ctgcgcgcgg cgctggtcga gtcgagctcc cgcatgagtg
    17281 cgacgatgcg caggacgccc tgccagtcgg tgggcgccga cgcgtcgatc gcacggagcc
    17341 gttcgagcag ctcccgttcc cgcgccaggc ggtcctccgt ccaccggacg aggtcgctga
    17401 tcagggcgga cggagtgaag gccgggtcct ccagcgcgcg cccgatctgc ttgagcgaga
    17461 gcccgaggga gcgcaggctc tccacgtgga agatcctgcg gacgtcctcg gcggagtact
    17521 cgcggtagcc gccgacggtg cggcccgtgg gccgcaccag ccccagggcg tcgtagtgcc
    17581 gcagcatccg ggtgctcacg ccggagcggc gggccacctc gccgatcagc aatgcggggc
    17641 ctccgacgtc tccgcatccc tggcagcccc ggtcgtctcg gccgtcccgg tcgtctgcgt
    17701 gggctcggcg tccgccggcg cggccgaggc ggcggcagcg cgttccgggc cgagtgcgac
    17761 cacgcgcctg gcctcctcga cggccgcgtc gaaaccggtt tgcgggttct gccggagcag
    17821 ctcggtggca cgggcgtgcg cggccactgc cgggtcgggg ttcgccgccg ccttctccag
    17881 agcgggcctg gtcacgtcgc cgaggtcgac gagggcccgg ctcaggctca gctgcacgct
    17941 gcggtccccg cggccgagct gtcgaaccag ctcgtccgcc agctcgttct cctcgtcctc
    18001 gggcacgagg gccaccgcga cgcgccacgc ggtccgcgcc acctcgtcgt cggcgtcgcg
    18061 cagcatgtcg cgggtgatcc aggcccacgt gctcctgtcg ccgaccttgg agagcgtgtg
    18121 cagcgcctgg ctgcgggcct gggggcgctc ggagccgagc tcccggcgga tccgggggag
    18181 ggcgacctcg ggcgagaggc gggtcagcgc ccaggacagc atgtcccgca cgaagaagtc
    18241 cggctcgacc gcgcaccgtt cgaccagcgt ctccaggaat gcggggtcgg gattcgagcc
    18301 gaccgccagg gccgcctgga gccggaccga cgagtcctcg gcacccaggg cgccggccac
    18361 gcgggcgttc tgcggggtca catgggtcgt gttgatcgca accacctcct gcgcccaagt
    18421 ggaaaccttg tcaccgtgtc aaggtcaagc ccagtgggtc gcggcctggc acatggatca
    18481 ccggcagggc ggttccgccg atgagttcgc cgtcctcgaa cggtctgtcc ggcgacacga
    18541 ccgttctcgc caggagtgcc atgtccacca tccagccagt gatcctgacc gccgaccagg
    18601 acgccctgct cgacttctat acgacattgt tcggcgccga gcagatcttc cggataccgg
    18661 aggaaggtcc ggccttctac ctcggcctgc gcatcggcga caccgacctg gggctggtgg
    18721 ccaagccgga tgcggggacc ggggcggcac cgcgggtcct gctcagcatc ggtgtcgacg
    18781 acgtcgacga gacgctcggc cgggtggagg cgctgggcgg ctcggtccgc agcggcccca
    18841 acgacatgcc gtggggacag cgcgtcgccc acatcctgga ccccgacggc aacccgctga
    18901 acctgaccca gccgatcccg gcccggtgac gccttgcccg cgcgctccag ctcgacgagg
    18961 ccgggcgcgc ccacctgccg gacctgcccg ggcggcgaac accacgcctc gggcacgagc
    19021 gcggcaccgc cccgccgcgc agcggatccc ccgcttggtg ccgcgaccat ggacacgcac
    19081 gcgtgggacg gctgcggccc cacgttcccg gccaacggga acctggggcc gcgggttcgt
    19141 caccgaggga gcgagcggac cgacgggcat cacactcgct ggtagcggag cgaggtgcgg
    19201 ccggagccgt ccgagaagat gtcggcccgg tacgactggc cgacgctgtc gacccgcctc
    19261 acctggagtc ggatcacggt ctccctggtc acggtgatgc gctcactgat cggagccgtc
    19321 gactgcctgg cgatggtccc actcagcggg gggttgttca tgtgcgtgac cagacgctcg
    19381 ctttgcggca ccacggcgcc atcggtggcg tcccagagcc gggcctggat ggacgcgagg
    19441 aggcgatcgt tgccgtcgcc agcgatgcgt ccgcggacgt ccgcgtccag caggtacgtg
    19501 ccgggacggg gcagcgtgac cgccagaggc acgttcaccc accttccgga aggagtcggt
    19561 tgcaggtcca cacgactttg ctgcatgtgc tggacgcccc cgtcgggacc ctgcgcggag
    19621 gcggtggtgc tgttctgcag gctgatcacg gcgccggcca ggcagagaag gacggccgcg
    19681 atgacagcgg agacgcggtg tcggatgaat ggcatgcttc ctcccggact gatgcccgat
    19741 ggacactgac gtcagggtag gaaacggagg atgaggggcg tagtcactct tatgagtgaa
    19801 ggagtagcta atcggatagc cagtcatatc gggcgcacaa caggcgtatt caaggacggt
    19861 tcgacaccgt cacgcacctg cggacgtcag ggaccggccc gctgggcgag gacgtcgagc
    19921 gcagagcgga tgagtgtgct ggaggtgtgc acggtgtagg ggaagaagac gaccttcacg
    19981 ccgcgccggg cgaattctgc ctccaggttc tgccacagct ccgtaccgag ccagtcgtca
    20041 cccttgaaga tgacgtcgaa gcccacttcc ttccagattt cgagtttgtc ctcgacggtg
    20101 gcgacgaaga cgtcgtcgac gtaccggacg ctgcggacga tctccagtcg ctcggataac
    20161 ggcaccacgg gcggctggtt cttcaggcgc accaccaggt cgtcggaaca gacgccggcg
    20221 acgagccggt cgcagtgctc ccgtgcctgg cgcaggatgt tcaggtggcc cacgtggaag
    20281 aggtcgaaaa ccccaggcgc gtacccgagg gtctctccca tcaccgcgct cccgtcggcc
    20341 gcttcccggc gaccgcggtc acctggagcg gcttcgaccg gggcgtggtg ttcttcccgt
    20401 cggtgacggc gatcgcgtag cggtggcgag agccgcgagc cacggagtcc gtgtacctca
    20461 tttccggtcg gtgccattcg accgaccgct gcttcggaga ggccacgaga cgcccgtccc
    20521 ggtagatcag atacgtcagt tccgcgtcgt ccctgtccca tgcggcacgc caggtgagcg
    20581 tgaccttgcc cgcgcgggag gacttgcccg agagtctcgg ggccgcttcg ggggccttgt
    20641 tccgcggacc ggtcccgaaa cgcgtcaggc tctgctgtgc tctgccgttg accgtggtga
    20701 actcgccgcc cgcccagagg gttgtgccgg ccatcaccag cgtccggggg ccgactcctt
    20761 caccgagtcc gtcgttggtg tcggggaacc agtgcagcag gcgcttgtca tcgaccgact
    20821 gggccaggaa gttccggcga ggcccgtcgg ggaaaccgcc cggcgtacgg ccgcagtagt
    20881 gggaatggga cgcgctgtag agcacgttcc cgtgcacgac gaccgcctgg gtggcgccca
    20941 ggcagaagtc cttccagagc atcgtgccgt cggacagacg tccggcgatg cgcccgtcga
    21001 aaatgcccgt gccacggccc tcggctccca gatagaagcg ggtgccgccg cgggccagtg
    21061 acttcaccga ggctctcggc ggcagccatt ccgggaagga ggtcaccgtc gaaccggtct
    21121 ggggatgcac agcgaccagc gcccgctcgg tcctgccgtt gacgttctgg aagtcgccgc
    21181 cgacgaggac ctttccgtgg tccggtgcgg cgaggacggc gcggaccggc ccgtcgatgt
    21241 ccgcccggaa aggcaggagc ctgcctttcc gggtgaagga cgcgagatgc tttctcggct
    21301 tgccgttgac gaccgtgaag tcaccgccca ggtacaccgt gctgccggtg gtctcgatgg
    21361 cccgcaccgt ggccgtcaca gcggggcgga aatccctgcg caccgagcac gtggccgtgt
    21421 cgagcgcgac cgcgctggcc actccgccgc cgtcgaccct gccgaacgag ccgccgacgt
    21481 agagcacctt gccgtcgggc gacgccttca acgcccgcac cgtcgcggcg ccccgggtga
    21541 agctgtgggc acacggcaga agtctgccgg tcgcggcgtc gaacgccgcg aagttcttcc
    21601 gggcggtctc cttctcaccg ggcttggcgc ccggcgggcg gaccctgtcg aaggtgccgc
    21661 cgacgtacac gacaccgcgc gcgtactcga ccgtccagac gatgccgttc gtctgccatg
    21721 tcgccaaggg ggcggcggtc aggagctcgg ggccgcgtgc ctgcgcgccg actgcggtcg
    21781 tgagggaagc ggccgcgagg agggccaccg cacaagccgt ggtgacggtc ctcgtcgtgc
    21841 tctttctcag catggaacat ccccagtcca gtgtgcgggg tgacccgttc tctcccggcg
    21901 caggccactt tccgaaagta gatgcccggg cctcttctca ccggaatcga caagcgggcc
    21961 caccgcgaga tcatccgatc ggcatacttc tccgaccggg ggatgccggg gcggcacgct
    22021 tcacctttcc ggccgccatg ggaagcacga acggcctgag gacagaggcc gtccgctcac
    22081 agatgagcgg acggcctcgt cggtgtcgcc gcggcaggct gccgcgccgt cggtacgacg
    22141 gtcagtacgc cagccccaca tgggccagcg cctgcttcag cagcaccccg tgcccgcccg
    22201 gcatctcgct ctgcaccgcc ggggaggcgg cctcctgcgg gctgaaccag acgaggtcca
    22261 gcgcgtcctg gcggggccgg cagtcaccgg tcaccggcac gatgtaggcc agggagaccg
    22321 cgtgctggcg cgggtcgtgg tacggcgtga tgcctgccgt cggaaagtac tccgcgaccg
    22381 tgaacggctg gagcgaggcg gggacgcggg gcagggcgac cgggccgagg tccttctcca
    22441 ggtggcgcag cagcgcgtcc cggacccgct cgtggtgcag gacgcggccg gagaccaggg
    22501 tgcggctgac cgtgccgtcc gggccgatac gcagcagcag tccgatgctg gtgacttcac
    22561 cgctgtcgtc cacgcgca
//
