LOCUS       NZ_AP024135            27605 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6413797
            Orig. end                         :: 6441402
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27605
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="25"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..27605
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27605
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17605](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17605
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    complement(857..872)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.9"
                     /tool="antismash"
     misc_feature    939..953
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            complement(1046..1735)
                     /locus_tag="K6K39_RS28195"
                     /old_locus_tag="EASAB2608_05774"
     CDS             complement(1046..1735)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967610.1"
                     /locus_tag="K6K39_RS28195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05774"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079081221.1"
                     /transl_table=11
                     /translation="MKKVLVVEPDAAAAETTAGDLRRQGYAAHTVDRGARILRAYHDAD
                     LVLLSLDLPDIDGLEVCRTLRAESDIPLIACTHRDNELERVLALKAGADDCVLRTWSPR
                     EIGARIEAVLRRTRPHSVGADSISLRPLHIDPRTREVRLRDRVVDVTATEFELLYTLAA
                     RPDSVVSRKELMAKVWGSNWVRTSRTIDTHVSSLRAKLGSSRWIITVRGVGYRMGHVGQ
                     VPEVSAG"
     gene            complement(1732..2577)
                     /locus_tag="K6K39_RS28200"
                     /old_locus_tag="EASAB2608_05775"
     CDS             complement(1732..2577)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.5"
                     /locus_tag="K6K39_RS28200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05775"
                     /product="transposase"
                     /protein_id="WP_260335701.1"
                     /transl_table=11
                     /translation="MGLFLATGTRCFPVDWSLVLDGAWDWDDLRRRRARIPEAETGRPV
                     GAFVLGFAAGVTAAQPRLPEAPWVLNLTQRCDDASGVMAGLARRGLDFVCEVDSGQIVL
                     VGRPAPRVTTVGELMEEPHARQPHALMRPAEPGGSRAVRVNVYTGAVRLSQRGAAKDGV
                     SRTYHVLEQLSADGGQPARYWITSLMSRGVEEVLALARSQATARTTVAALREGFGVLDF
                     EGRSFPGWHHHMTMVSAAYAYRHLYGAPGAVRAPAARLSAARADTAGYWADTGAKGLGA
                     "
     gene            complement(<2639..2980)
                     /locus_tag="K6K39_RS41190"
                     /pseudo=""
     CDS             complement(<2639..2980)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.5"
                     /locus_tag="K6K39_RS41190"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSSMGVSVAAGDRERIQTFVESVFNPLHRAEQRRWARAYLWGLLH
                     TPGKKTPRRMAEAGLLPAGAAHGLHQFINSSTWSWEPVRRALGRTIAAHRPAYAWTVAD
                     LLIPKQGEHS"
     misc_feature    complement(2801..2803)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3015..3029
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    3309..3325
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(3320..4555)
                     /locus_tag="K6K39_RS28205"
                     /old_locus_tag="EASAB2608_05776"
     CDS             complement(3320..4555)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675890.1"
                     /locus_tag="K6K39_RS28205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05776"
                     /product="MFS transporter"
                     /protein_id="WP_059253904.1"
                     /transl_table=11
                     /translation="MSASPDTAAASGTVPPTRRESAEPRQKLPMFALLALATAVFITSL
                     TETLPAGLLPEMSHDLRVSESATGQTVTIYAIGTALTAIPLTAATAGWRRKRLLLTAVA
                     GFAVANTVTAVSSVYGLTMVARFLAGVAAGLAWALLAGYARRMAPVPLQGRAIAVAMAG
                     IPVALSLGVPVGTFLGQALGWRVAFLSMTALTVVLLLWIVAAVPDYPGQQRGERPRMLR
                     ALGVPGVRPVLFVTLVFVLAHTVLYAYIATFLDGLGMGDQTDLVLLAFGVTSLLSIWVV
                     GAQIQYRLRALTIASTLLVAAAAALLAVLSDGGALVYVAAVLWGLGWGGLPTLLQTAVG
                     DAGGDQADAAQAMLVTLWNVAMAGGGVLGGVLLDATGSGSFPWTVLLLLVPVFAVVLAA
                     RGHGFPARRRAM"
     gene            4780..8478
                     /locus_tag="K6K39_RS28210"
                     /old_locus_tag="EASAB2608_05777"
     CDS             4780..8478
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609628.1"
                     /locus_tag="K6K39_RS28210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05777"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_063808661.1"
                     /transl_table=11
                     /translation="MRLGVLGPLAVWDDEGEPVQVPETKVRALLADLLAHDGGPVSADR
                     LIDDLWGDQLPGNPAGALQAKVSQLRRVLGRERLLRQPPGYGLRLDPADEVDVERFGRL
                     VAEARAVADPRARADLLTEALGLWRGPAYADFADEEFVRAARECLAEQRLAVLEERAEA
                     RLAAGDHLLLAGELAALVAEHPLRERLRAVQMQALYRSGHQGEALASYEDLRTRLAAEL
                     GACPGPTLSALHQAMLRQDPGLDATAPAPVAGAGSWYAGASPAGSPYAGAFAGAGGAGP
                     VPAGVSYAGQPYGASPYAGASPAAAPNPGPAYGAPSPAAASDPGSSPGTVSPAALSHGA
                     PPSAGPSLTASPDAGLSDGEPSHAGPLHGALPPIESPLVTASPSAPPPTAAAPPRSEDG
                     AVPTPPAPSAPPTNLPVPLTALIGRAEALGRLSRLLGRQRLVTLTGPGGVGKTRLAVAA
                     AQDAAAGGGAAGLPDGAWFVEFAGVRSATPDDLAAIVAATLGIRDDAPSAPPATGTGAT
                     SPVHRLTAALRDRRTLLVLDNCEHVVAAAAELVALLLRSAPQLRILTTSQEPLALAGEA
                     VFLVEPLPTPDAVRLFTERAAACAPGFRLGSGEPGGPDGGADHAAVAEICRRLDGIPLA
                     LELAATRVRALGVRELAARLGDRFRVLTSGQRGAPARQQTLRAMIDWSWELLSPPERTV
                     LSRLAVHRDGCDLDAAEAVCAGEGVAGDAVLDLVTRLVEKSLVVVADGPAGPRYRLLES
                     VAAYATERLHESADEAAARERHLHHYLALAERAEHRLRGPRQQDWLARLDTEACNLRAA
                     LDEAVRRAAAGHSAEAVRLATALSWWWLLRGRLTEARRALAAVLAATAGDPDPELALLH
                     SGFVLLTGERTVTCDADAVPDPVRRARALWLNAYGRFSAGDLDGSRALNTRALIHFEAA
                     DEQWGIAAALGLRAALALVRGDLDGLARDGQRSRALFRDLGDRWGELQTVSPLAALAEI
                     KGEYAQAAHRQHEGLQIARELSLEAEVSARLSGLGRLALLAQDFDRARDLHEQARRIAV
                     EQGYKYGEIHADMGLALGARRAGDIDAAEAHLLRIRDAHADASSPAGDHLLHAELGFIA
                     ELRGDAAEAAAHHLRGLSIAHCLDEPRALALSLEGLAGAATLCGHRSGAGCAALLLGAA
                     HAARRSVGAPLPPAERGDVDRVTAAAQEALGPRAFTEAFERGAWLSPAEAEHQVRTTLA
                     ALVDKAA"
     misc_feature    4786..4788
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8501..8896)
                     /locus_tag="K6K39_RS28215"
                     /old_locus_tag="EASAB2608_05778"
     CDS             complement(8501..8896)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091427.1"
                     /locus_tag="K6K39_RS28215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05778"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_059253906.1"
                     /transl_table=11
                     /translation="MRIGELARRSGVSERSLRYYEAQGLLSSERTPGGHREYGDWAVDR
                     VIRIQALYAAGLNSKKIAQLLPCMRDGDGTPSASATPRLVDELTAERDRLDRMIADLVR
                     SRDVLDGIISTASAGLGSAALSGTGGA"
     gene            9000..9740
                     /locus_tag="K6K39_RS28220"
                     /old_locus_tag="EASAB2608_05779"
     CDS             9000..9740
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-124). E-value: 2.8e-15. Score:
                     48.6. Matches aSDomain:
                     nrpspksdomains_K6K39_RS28220_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018842558.1"
                     /locus_tag="K6K39_RS28220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05779"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_059253908.1"
                     /sec_met_domain="adh_short (E-value: 3.7e-31, bitscore:
                     107.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7.6e-31, bitscore:
                     106.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELTGKVALVTGGSRGIGAAVAQRLADAGAAVALTYVQAEDRAR
                     EVAKRIEENGGRAAVVRADLTRPNDAAEAVEQTVRELGGIDILVNNAGFLAYGPLDEVT
                     PEYLDKVLAADVRSVFLAAQAAARHMGDGGRIISIGSCFNGRVPAGNFVLQATAKTALV
                     GLTKGLARELGPRGITATIVDPGPIDTDMNPADGDSAEWQASLTALGRYGEVEDIAAAV
                     AYLAGPAGRYITGTAIAVDGGYTA"
     aSDomain        9021..9371
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS28220_PKS_KR.1"
                     /evalue="2.80E-15"
                     /label="K6K39_RS28220_PKS_KR.1"
                     /locus_tag="K6K39_RS28220"
                     /protein_end="124"
                     /protein_start="7"
                     /score="48.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGGSRGIGAAVAQRLADAGAAVALTYVQAEDRAREVAKRIE
                     ENGGRAAVVRADLTRPNDAAEAVEQTVRELGGIDILVNNAGFLAYGPLDEVTPEYLDKV
                     LAADVRSVFLAAQ"
     CDS_motif       9027..9095
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS28220_0001"
                     /evalue="1.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS28220"
                     /protein_end="32"
                     /protein_start="9"
                     /score="21.1"
                     /tool="antismash"
                     /translation="LVTGGSRGIGAAVAQRLADAGAA"
     misc_feature    9850..9865
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.23"
                     /tool="antismash"
     misc_feature    complement(9850..9868)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.82"
                     /tool="antismash"
     misc_feature    9853..9866
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.87"
                     /tool="antismash"
     misc_feature    complement(9853..9868)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            10001..11152
                     /locus_tag="K6K39_RS28225"
                     /old_locus_tag="EASAB2608_05780"
     CDS             10001..11152
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947770.1"
                     /locus_tag="K6K39_RS28225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05780"
                     /product="isopropylmalate synthase"
                     /protein_id="WP_059253910.1"
                     /sec_met_domain="HMGL-like (E-value: 4.7e-46, bitscore:
                     156.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAESANEASLPQPPHLSDATLRDSAHMGGVEFGPKDATVISELLV
                     KTGIDLVEVGMVSGPNSKDADLVLATHEAITPERSMTLVVVRDREQVKKALDEAERLGV
                     RHIMYSIPTSEQHAKLKLGSPSAKFLNVLARSAISQAKERGFHVTFSGEDGARTPKERL
                     VPYVTAGFEAGADRFRLAETVAYLSPWQMEEVIADLTAIDGSEIEIHSHNMLGMAVANS
                     LAAVRAGAQWISATVGGIGERGGNAPLAELLTSLRVVYGDTRFDLSHLTELSRVALKGA
                     GLGSAFQSGPTTPHAFAYELPGQLSHPEAYETLPAELVGNTRELRVRTRLTPALVRWAL
                     AGADIDVDVEDFTAWLIERQERNGAPVLDQEAVRKAAIDFQAA"
     gene            11332..11517
                     /locus_tag="K6K39_RS28230"
                     /old_locus_tag="EASAB2608_05781"
     CDS             11332..11517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="K6K39_RS28230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05781"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_059253912.1"
                     /transl_table=11
                     /translation="MSTAVLTGSCPECETELTVPEMVEGETLSCPECMLTLRIEGISDG
                     RLTLQMVEVQLRDWGQ"
     gene            11519..12367
                     /locus_tag="K6K39_RS28235"
                     /old_locus_tag="EASAB2608_05782"
     CDS             11519..12367
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947772.1"
                     /locus_tag="K6K39_RS28235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05782"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_059253914.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.4e-08, bitscore:
                     33.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.2e-26, bitscore: 92.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2.3e-08, bitscore:
                     32.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNRVAVVADRVGWEERRLIETAQDFGLRFDWVNDESLCAGHRDA
                     LSVKDYDALMVRSRSYTRGGLIATLAEADGFRVLNSAAAIHSCENKLVLRAVLREAGVP
                     VPEFRLALSRKDFEKALGELGVPVVLKPVYGGMGKRVTLVRDPDLAHSVYDYVEDLGHA
                     FEQACLVEPYLGGGSIRCLVVGREIVAAAEFESAGTDWRSNAALGNQSRALAHDPDVQK
                     IVDGVVDRLGSGIYGVDLFKTPSGYLVNEVNHAPAWRGVASTTGVDIASVVVRYVQETL
                     E"
     gene            12364..13422
                     /gene="argC"
                     /locus_tag="K6K39_RS28240"
                     /old_locus_tag="EASAB2608_05783"
     CDS             12364..13422
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379927.1"
                     /locus_tag="K6K39_RS28240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05783"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_059253916.1"
                     /transl_table=11
                     /translation="MIRVGIVGASGLAGGELIRLVNQHPELELTFLGGNSSAGRRPAEL
                     HPGLRLDLGLTVEPVTADRVAERCDVVFLATPAPVSARLAAELADRVPCVTDLSGAFRI
                     RTPELHERWYPKAERTTELADRFVYGVPELVGDQLVDAALISVPGCYATAITLGLAPLT
                     LGLGLNLRTVVIDGKSGSSGGGLQLRVPDLHPLRNGAIAPYAPTGHRHAAEVSDFLLRS
                     KPGSVGSLAMSAYGVSHVRGLLASTYVYTDDQVDQRELQRAYIKFYKEHTFVRVRRHNE
                     TLIPVPDPQAVLGSNYCDVTALHDPDGGRIVVLAALDNLVKGAAGQAVQAVNKRFRLPE
                     DTGLTMQPVMPA"
     gene            13419..14222
                     /locus_tag="K6K39_RS28245"
                     /old_locus_tag="EASAB2608_05784"
     CDS             13419..14222
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947774.1"
                     /locus_tag="K6K39_RS28245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05784"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_059253918.1"
                     /transl_table=11
                     /translation="MTETQAQLPPTVVKLGGSCLADLEGGWWDDLAAHGRERPLILVHG
                     WSKPLKQLSPRYSEPSAILRDRYGNQSRWTTPEVIADIKTVSADLGREVLQRLTRRGIT
                     AERLLGSDGLVSAGAGERWWWKDKQLVELENLVGPITGVDPAPLTGLRPGHAYLVTPLA
                     RNDAGQEVNTDADRAAAAIAGATGATDLILVTDVAHLLIDGEPVREITAQGAAEFRDKG
                     ATGGMRKKLRAAGEALDRGVERVVIGSAPVTDLLAARTGTVITRT"
     gene            14234..14797
                     /locus_tag="K6K39_RS28250"
                     /old_locus_tag="EASAB2608_05785"
     CDS             14234..14797
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609639.1"
                     /locus_tag="K6K39_RS28250"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26.; Members of
                     this family of hydrolases with an active site Cys residue
                     belong to MEROPS family C26.; Members of this family of
                     hydrolases with an active site Cys residue belong to MEROPS
                     family C26; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05785"
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="WP_094372801.1"
                     /transl_table=11
                     /translation="MAKTRVLVVNNRTLSLKQLRGRFEALGSDTDTVDAASVPARLDGR
                     YQAIVLSGTKVRAYDQEYYKPLVDLVMNADVPVFGICGGMQILAVANGAQLAEGPQRVG
                     GYEVQVDKEEPLFTHVKPTVTVFHRHTLYLKEAPKGFRSIGRSEHAPVEFLRSDDGRIY
                     GSQAHLEFRSDGLEILRGFAQLYQ"
     misc_feature    14831..14851
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.78"
                     /tool="antismash"
     gene            14832..15953
                     /locus_tag="K6K39_RS28255"
                     /old_locus_tag="EASAB2608_05786"
     CDS             14832..15953
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379929.1"
                     /locus_tag="K6K39_RS28255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05786"
                     /product="Glu/Leu/Phe/Val dehydrogenase dimerization
                     domain-containing protein"
                     /protein_id="WP_094372800.1"
                     /transl_table=11
                     /translation="MSPVDDNTQDPALVVHLNGSGGTIKSWVVIDTLVDGLAMGGVRMT
                     PGVTQEEVAGLARDMTHKFTLAGLRIGGAKGGIVSDGSNREETFRTFGRTVKPLLHGGI
                     HLGIDMGVTPADRAVFFDEAGYDPRYRLGAPDMPIDWRTYYEPLIDVTGHGVGVAAVTA
                     LEASGRTEPARVVVQGFGAVGRAVARFLEDRGHTLVGVADAQGTISADRLPVADLVAVT
                     DEFGLIDRSRLPQHVTLSDGPDAWLDVDADLLILAAQKHALNAENAHRLRAGLVVEGAN
                     LASDAQAREKARAAGATLVPGVIANIGGAGAAALAVTRVVPFELAAEARKAWVFDWIGD
                     RVRDNTRALLEIAAGRAGDPLPELLSVRRGELR"
     gene            15950..17605
                     /locus_tag="K6K39_RS28260"
                     /old_locus_tag="EASAB2608_05787"
     CDS             15950..17605
                     /NRPS_PKS="Domain: AMP-binding (36-452). E-value: 7e-78.
                     Score: 253.9. Matches aSDomain:
                     nrpspksdomains_K6K39_RS28260_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947777.1"
                     /locus_tag="K6K39_RS28260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05787"
                     /product="AMP-binding protein"
                     /protein_id="WP_260335703.1"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-81, bitscore:
                     271.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTMVPPAHIPAPATDRAAEYRSRGWWRDETFLDDLRRQARIRPR
                     KLAVAGRRLGEARTDTLDYAELSLLTDRFAGALLELDVRRGDVVAVQLPNRWEMVPLMY
                     ACMAVGAVICPIAPECQGEELRHRLQLTEARLCVTVAEYDGHPLARDIAGLRSALPLEH
                     VVVVGGHAPEGTLDFHDHFVAVPWEDAHMGDLEGRALGPDEPFVVLFTSGTTGFSKGVV
                     HSQNTVHSGVRGYVDTFLLRDDLVAVVTTPLVHYSGFGQGVLAGVMLGGTIAFQDGRNH
                     TSLLDLAERYGATLLYGPPPTLFGVAAAQRADRHDVSRLRYTITGAAPVLQELVDELRD
                     TFDTATYSVWGMSEFGPITISRLDYDQNWSAHSHGRPIDAMEIRIDLCDNPDKRAPVGR
                     LRVRGASQALGYYRNQDAFDAELTADGWFDTGDVAREDGRGGIRVLGRAKDAILRDGIV
                     VPMAELEAILSAHPKVAEATLVGPTGRTDDSVVAVVVPRGGARPTLREIREHLLDRGQD
                     PRFLPDRLDLVEALPKTLTGKVKKAELRRRLAGA"
     aSDomain        16058..17305
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS28260_AMP-binding.1"
                     /evalue="7.00E-78"
                     /label="K6K39_RS28260_AMP-binding.1"
                     /locus_tag="K6K39_RS28260"
                     /protein_end="452"
                     /protein_start="36"
                     /score="253.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRQARIRPRKLAVAGRRLGEARTDTLDYAELSLLTDRFAGALLEL
                     DVRRGDVVAVQLPNRWEMVPLMYACMAVGAVICPIAPECQGEELRHRLQLTEARLCVTV
                     AEYDGHPLARDIAGLRSALPLEHVVVVGGHAPEGTLDFHDHFVAVPWEDAHMGDLEGRA
                     LGPDEPFVVLFTSGTTGFSKGVVHSQNTVHSGVRGYVDTFLLRDDLVAVVTTPLVHYSG
                     FGQGVLAGVMLGGTIAFQDGRNHTSLLDLAERYGATLLYGPPPTLFGVAAAQRADRHDV
                     SRLRYTITGAAPVLQELVDELRDTFDTATYSVWGMSEFGPITISRLDYDQNWSAHSHGR
                     PIDAMEIRIDLCDNPDKRAPVGRLRVRGASQALGYYRNQDAFDAELTADGWFDTGDVAR
                     EDGRGGIRVLGRAKDAI"
     CDS_motif       16571..16621
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS28260_0001"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="K6K39_RS28260"
                     /protein_end="224"
                     /protein_start="207"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VLFTSGTTGFSKGVVHS"
     gene            complement(17679..18743)
                     /locus_tag="K6K39_RS28265"
                     /old_locus_tag="EASAB2608_05788"
     CDS             complement(17679..18743)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470615.1"
                     /locus_tag="K6K39_RS28265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05788"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_221335020.1"
                     /transl_table=11
                     /translation="MTERAPVRDYGGTATMADALSVLDLVAVGEGHTTREALRTSARLA
                     RLAEARGFQRYWVAEHHSMPGIASSSPAVILAYLAAQTTRIRLGSGGVMLPNHAPLVVA
                     EQFHTLEAMAPGRVDLGLGRAPGTDQLTARALRRTHGPATGDTFPADVAELLGFLDDDF
                     PDGHPYRRVHAVPGPVQGPSGGRPAVWLLGSSGFSAQLAGRLGLPFAFAHHFAGHHTVP
                     ALELYRQSFRPSPVLAEPYTVVGVFAFAAETEEQARDQALTGALTTVRFRSGRPGLVPT
                     PEEARSHVFTAYERKILGGWLEHAVHGTPDVVRERLGELRKRTQADELMLASNAHGLQE
                     RLTSLSLIADSYGM"
     gene            complement(18825..19718)
                     /locus_tag="K6K39_RS28270"
                     /old_locus_tag="EASAB2608_05789"
     CDS             complement(18825..19718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609643.1"
                     /locus_tag="K6K39_RS28270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05789"
                     /product="fumarylacetoacetate (FAA) hydrolase"
                     /protein_id="WP_059253927.1"
                     /transl_table=11
                     /translation="MSIIFECTYQGRRYAGHGLPVPGSPLTLYPVTDGQLRAALVAGGG
                     PEGLRSALAGLDGRIEVEPGDAGLTFLPPLLPTASNNALINGFMGTHRSKFDRAPEPDE
                     EFTAPNYYIKGFGSWLRMPDEPLTTPADPVWLLEEPEVVLVYANDDQGVPHYAGYTFGN
                     DLNDIGLHLKNPWAWTPYAKLCETSITPWLFLDTPPETVTGSVTIERDGAEAWRGPFSC
                     GADSLFHRIPDMADHLFAHPLLRRPGLVNYLFLGADKATYHDGFRIENGDRMVIDVSSH
                     GVVLANEVRYGAAAPK"
     misc_feature    complement(19712..19726)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            complement(19734..20972)
                     /locus_tag="K6K39_RS28275"
                     /old_locus_tag="EASAB2608_05790"
     CDS             complement(19734..20972)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379921.1"
                     /locus_tag="K6K39_RS28275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05790"
                     /product="MFS transporter"
                     /protein_id="WP_221335021.1"
                     /transl_table=11
                     /translation="MTSAEPSTGTATSVPVPDDASTAERKLPMAALLALAVAVFITSLT
                     ETLPAGLLPDMSASLHTSESATGQTVTIYALGTVLTAIPLSAATAGWHRKRLLLTAMAG
                     FAVANTVTALSVNYPLTLVARFVAGVAAGLAWALLAGYARRMVAPHQEGRALAIAMAGI
                     PVALSLGVPAGTFLGQVVSWQAAFLVMTALTVVLLVWIAAVAPDYPGQQAGGKIPMRST
                     LRAPGVAAVLTVTLVFVLAHTLLYAYIASFLDHIGMGAQVDAALLVFGVACLISIWVVG
                     MYIHRHLRTLTIVSTLLVGVAVAVMGAFSGSDALVYVAAALWGLGWGGVPTLLQTAGGQ
                     AGGEAAEAAQAMLVTLWNVAMAGGGIAGGLLLDAVGAEAFPWTVLILLVPVLAIVLASR
                     THGFPAPRSSANS"
     gene            complement(21036..22322)
                     /locus_tag="K6K39_RS28280"
                     /old_locus_tag="EASAB2608_05791"
     CDS             complement(21036..22322)
                     /NRPS_PKS="Domain: Aminotran_1_2 (48-379). E-value: 3e-41.
                     Score: 133.7. Matches aSDomain:
                     nrpspksdomains_K6K39_RS28280_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947778.1"
                     /locus_tag="K6K39_RS28280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05791"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_260335704.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4e-39, bitscore:
                     133.7, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.5e-05,
                     bitscore: 20.8, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAPSIPMSATLAADEALDRRRRAGEQVLPMAGGEIGLPVLPEL
                     RRRLAAAADANAYGPVPGSQALRASAAGYWERRGLATDPGLVVAGPGSKPLLFALLLAV
                     GGDVVVPVPSWVSYAAQARLVGARPVPVPIAAGQGGVPDPERLRAAVTAARAAGRDPRC
                     VVVTLPDNPTGTLASPGTVHRLAALARELDLVIVSDEIYCDLVYDTSVPAESPARHAPE
                     RTVVTTGLTKNLAVGGWRTGVARLPDSGIGRALHGRLVSVASQIWSSPPAPVQAAAAYA
                     FGEPPEVTERVAASRRLHEIVVRAVAGRLTAAGARVAPVRATCYLYPDFGPLRNHLARA
                     HGVHGGEDLVRFLGERHGVGVLPAGAFGELGDPLRIRVATSRLYGEDDERRTAALTAPD
                     PLELPWIRRYLEQFDTALADLTGARVLRA"
     aSDomain        complement(21186..22178)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS28280_Aminotran_1_2.1"
                     /evalue="3.00E-41"
                     /label="K6K39_RS28280_Aminotran_1_2.1"
                     /locus_tag="K6K39_RS28280"
                     /protein_end="379"
                     /protein_start="48"
                     /score="133.7"
                     /tool="antismash"
                     /translation="LAAAADANAYGPVPGSQALRASAAGYWERRGLATDPGLVVAGPGS
                     KPLLFALLLAVGGDVVVPVPSWVSYAAQARLVGARPVPVPIAAGQGGVPDPERLRAAVT
                     AARAAGRDPRCVVVTLPDNPTGTLASPGTVHRLAALARELDLVIVSDEIYCDLVYDTSV
                     PAESPARHAPERTVVTTGLTKNLAVGGWRTGVARLPDSGIGRALHGRLVSVASQIWSSP
                     PAPVQAAAAYAFGEPPEVTERVAASRRLHEIVVRAVAGRLTAAGARVAPVRATCYLYPD
                     FGPLRNHLARAHGVHGGEDLVRFLGERHGVGVLPAGAFGELGDPLRIRVA"
     gene            complement(22327..22512)
                     /locus_tag="K6K39_RS28285"
                     /old_locus_tag="EASAB2608_05792"
     CDS             complement(22327..22512)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="K6K39_RS28285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05792"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_059253931.1"
                     /transl_table=11
                     /translation="MSSATLTGACPECETELTVPPIVQGETLSCPECMLTLRVEEIADG
                     RLTLEMVEVQLRDWGQ"
     gene            22717..23475
                     /locus_tag="K6K39_RS28290"
                     /old_locus_tag="EASAB2608_05793"
     CDS             22717..23475
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237777.1"
                     /locus_tag="K6K39_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05793"
                     /product="arylmalonate decarboxylase"
                     /protein_id="WP_094372797.1"
                     /transl_table=11
                     /translation="MDIFPLPRLGLVVPPENPLAEPEFNRLVGAELNVYSARFPLTPGM
                     GVKETMLRYNDVLEDTLGTFGRMRLDAAVVACNASHYLLGPEGDRAFVAELSERFGYPV
                     QSTTQAILAVCEQFGISRLTLVSPYWDWLTETSRAFWEQAGVTVDRVVLAPAVPGEKDE
                     DHEFDPYRVTTRTLLERIRAAGLPDEGAVLFTGTGMGTLAALAELDREFRRTTLLTSNL
                     AAAWWARRAVGAAGAEVHPLLERLERGAAR"
     gene            23535..24290
                     /locus_tag="K6K39_RS28295"
                     /old_locus_tag="EASAB2608_05794"
     CDS             23535..24290
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (14-164). E-value: 6.8e-14.
                     Score: 44.1. Matches aSDomain:
                     nrpspksdomains_K6K39_RS28295_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552450.1"
                     /locus_tag="K6K39_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05794"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_086696786.1"
                     /transl_table=11
                     /translation="MATLSEAQTSDPLVAVVSGGASGIGAAAAAALTARGVRVAALDLT
                     PDEVAAPAVGIACDVSDDASVRGAVAEAVERFGRIDIVVNNAGIAAQGTVADNDDEEWR
                     RVLDVNVVGMVRLARAALPYLRRSPAAAIVNTCSVFAAMGVPRRVLYSASKGAVHSLTL
                     AMAADHVREGIRVNAVAPGAVDTPWIQRVLARTADPRAERDALNDRHPLGRLARPEEVG
                     EAIAYLAVDASGTTGTVLAVDGGIHDLRL"
     aSDomain        23577..24026
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS28295_PKS_KR.1"
                     /evalue="6.80E-14"
                     /label="K6K39_RS28295_PKS_KR.1"
                     /locus_tag="K6K39_RS28295"
                     /protein_end="164"
                     /protein_start="14"
                     /score="44.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AVVSGGASGIGAAAAAALTARGVRVAALDLTPDEVAAPAVGIACD
                     VSDDASVRGAVAEAVERFGRIDIVVNNAGIAAQGTVADNDDEEWRRVLDVNVVGMVRLA
                     RAALPYLRRSPAAAIVNTCSVFAAMGVPRRVLYSASKGAVHSLTLA"
     CDS_motif       23580..23648
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS28295_0001"
                     /evalue="9.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS28295"
                     /protein_end="38"
                     /protein_start="15"
                     /score="8.7"
                     /tool="antismash"
                     /translation="VVSGGASGIGAAAAAALTARGVR"
     gene            complement(24402..25424)
                     /locus_tag="K6K39_RS28300"
                     /old_locus_tag="EASAB2608_05795"
     CDS             complement(24402..25424)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612021.1"
                     /locus_tag="K6K39_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05795"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_086696787.1"
                     /transl_table=11
                     /translation="MCQEEDIEEKGDGRKRVEGTSPGVHFCARGLERYREALNDGTISG
                     DVPECLIVYRLLRPIPGVAGLYVPIPPKVAEAELSRSVVREIEHHENTLASLRSSFLAA
                     ESLYHRAQHDTGVPIESLRGADVISQSLRLVVEACKEELLTAQPGGGRSPALLAEALPR
                     DLAILRRGVAQRTLYQHSVRSHQPTLAYIERVTAEGAEVRTVDEVFERLIICDRAVAFI
                     PGIPERKNAALAVRHPGAVAFLVKVFDHTWARARPVSIAPEQHRPDLVTDSVRAAVLRM
                     VVTGHTDEAIAARLGMSSRTVSAHIKKVAEVLGSRSRAELGYLICQRRLLVLEEPVGTA
                     "
     misc_feature    complement(25594..25609)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.26"
                     /tool="antismash"
     misc_feature    complement(25595..25608)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.01"
                     /tool="antismash"
     gene            25917..26897
                     /locus_tag="K6K39_RS28305"
                     /old_locus_tag="EASAB2608_05796"
     CDS             25917..26897
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (halogenases)
                     ambiguous flavin-dependent halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016693.5"
                     /locus_tag="K6K39_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05796"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_086696788.1"
                     /sec_met_domain="Trp_halogenase (E-value: 4e-14, bitscore:
                     51.2, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSERYDVVVAGAGPAGLLAAALVAGRGHRVLLLERGPCPGALPG
                     VVVRERSAAVNVVIENERVAGLRHRPEGEPARTVRARYVVDASGGDSPLRRHVAGARGS
                     SGLAVYACFTAGGGAAGPRRFPFDGGWFWIAPAGDGLTRVGAVVRPDLAGLVRADPGRA
                     LSGFAEACPPVRDFLAGATRARGGPGLIRVRPHWSYADDRLWRPGMVLVGDAACAVGPQ
                     SPPSRGMHLACRGAGLAAGALDGFLRGAADEAAAFAEFERRYRTAYDETLHDEVLHDEV
                     LHDDALNHGAPDGAAPHGEVPHCEEPHEGLPFGDGPRSPLPGLSR"
     misc_feature    27270..27289
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.88"
                     /tool="antismash"
ORIGIN
        1 cggccccaga cggcctccag gtgggcgatc gcggtctgcg ggctcacctg ggcccgggtg
       61 atctcgtcgg cgtacgccgc ggcctcctcg tcggtgtcgg cgacgacgac ggtggcggtg
      121 ggcatgatcc gcaggtcgtc cggtgagcgg ccgtaccggg cgagacgccc cttgacgtcc
      181 cggtagaagg cgcgggcctc ctccagccgg ttgtacttgc tgaacacgac ctcggcgtcc
      241 gacgccgcga actcccggcc cgcgtccgac tccccggcct ggatgatcac cgggtgctcc
      301 tgcggagcac gcggggtcgt gaaccgcccc gagatgtcga agtgctcgcc gtggtgggcg
      361 aacgcgccgg ccccggggcg cacgaactgc ccggacgccg cgtccgcgag cacgtcttgc
      421 gcggcccagc tgtcccacag ctcacgggtc gtggccagga actcggcggc gcgcgtgtag
      481 cggtcggact cggcgaggaa gccgccgcgg cggaagttct ccccggtgaa ggcgtcgaag
      541 ctggtcacca cgttccagcc ggcccgcccg ccgctgaggt ggtcgagggt cgccagccgg
      601 cgcgccacct cgtacggctc gttgaacgtg gcgttgacgg tggcggcgac cccgagccgg
      661 gtggtgacgg cggccagcgc gctcagcatc gtcaggttgt ccgggcggcc ggccacgtcc
      721 aactcgtaga gacggccctt gtgttcgcgc agccgcagtc cttcggcgag gaagaagaag
      781 tcgaacctgc cgcgctccgc cgtccgcgcg aggtgcacga aggagccgat ggccatctgg
      841 cttgcggacc gggggtccga ccagacggtg acgttgtgga tgcccggcag ttgagcggcg
      901 agatggatct gcttcgtcac aatgctcctt ctggacgatg ctccttctga ggaggctcgt
      961 acgcctgcgg cgcgaaacgg gccccgggca cgcgcggtgg ccggcaccgt gcgtgcccgg
     1021 ggccctcgac ggcgggtggg acggttcagc ccgcggacac ctcgggcacc tgcccgacgt
     1081 gccccatgcg gtagccgacc ccgcgcaccg tgatgatcca ccggctggag ccgagtttcg
     1141 cccgcaggct gctcacatgg gtgtcgatgg tgcggctggt gcgcacccag ttgctgcccc
     1201 agaccttggc catcagctcc ttgcgggaga cgacggagtc gggccgggcc gccagggtgt
     1261 agagcaactc gaattccgtg gcggtcacgt cgaccacccg atcgcgcagc cgcacctccc
     1321 gcgtgcgcgg gtcgatgtgc agcggccgga gcgagatgct gtccgcgccg acggagtgcg
     1381 gccgggtgcg ccgcagcacc gcttcgatcc gcgccccgat ctcacgcgga ctccacgtcc
     1441 tgagcacaca gtcgtccgct cccgccttga gcgcgagaac cctttccagt tcgttgtccc
     1501 ggtgcgtgca ggcgatcagc ggaatgtcgc tctccgcccg cagcgtgcgg catacctcca
     1561 gtccgtcgat gtcgggcagg tccagggaga gcagcaccag atcggcgtcg tggtacgcac
     1621 gcaggatccg cgccccccgg tcgacggtgt gggcggcgta cccctgccgc cgcagatcac
     1681 ccgccgtagt ctcggccgcc gcggcgtccg gctccacgac cagcactttc ttcacgcgcc
     1741 caggcctttc gctccggtgt ccgcccagta gccggcggtg tccgcgcgtg ccgcggacag
     1801 ccgggcggcc ggcgcgcgga cggcgccggg agcgccgtac aggtgccggt aggcgtacgc
     1861 ggccgagacc atggtcatgt gatggtgcca accggggaag gaacggccct cgaagtcgag
     1921 tacgccgaat ccctcccgca gcgccgccac ggtcgtccgg gcggtggcct ggctgcgggc
     1981 cagtgccagg acctcctcca cgccccggct catcaggctg gtgatccagt accgggccgg
     2041 ctgcccgccg tcggcggaga gctgttccag gacgtggtag gtccgcgaga cgccgtcctt
     2101 ggcggccccg cgctgggaca gccgcaccgc cccggtgtac acgttgaccc gcaccgcccg
     2161 ggaaccgccg ggctcggccg ggcgcatcag cgcgtgcggc tgccgggcgt gcggctcctc
     2221 catcagctcc ccgacggtgg tcacccgcgg ggccggacgg ccgacgagca cgatctgccc
     2281 ggagtcgacc tcgcacacga agtcgagccc gcggcgggcg agtccggcca tgacgccgct
     2341 cgcgtcgtcg caccgctggg tgaggttcag cacccagggc gcctcgggca accgcggttg
     2401 cgcggcggtc accccggcgg cgaagccgag gacgaacgcc cccacgggac gcccggtctc
     2461 cgcctccggg atgcgcgccc ggcgcctgcg cagatcgtcc cagtcccagg ccccgtcgag
     2521 gacgaggctc cagtcgacgg ggaagcaccg ggtgcccgtc gccaggaaga gtcccacccc
     2581 cccgctggca gttgatggtg cgcccggtcg cttggtccag gcgacggtgc acccccaccg
     2641 agtgctcccc ctgcttcggg atgaggagat cggcgaccgt ccaggcgtac gccggccggt
     2701 gcgccgcgat ggtccggccg agtgcgcggc gcaccggttc ccagctccag gtgctgctgt
     2761 tgatgaactg gtgcaggccg tgcgccgctc cggcgggcaa taaacccgcc tcggccatgc
     2821 gccgcggggt cttcttgccc ggagtgtgga gaagccccca caggtacgcg cgggcccagc
     2881 ggcgttgttc cgcccggtgc agcggattga atacgctttc aacaaaagtc tgtatgcgtt
     2941 cgcgatcgcc ggcagcgacg ctcactccca tcgacgacat gtttaactac gccccctcgc
     3001 agtcgtgtcg ccccatcgct caggtcgatg tacgggcagt cgtacgaggg acaaagctac
     3061 cggctgcatc gccaaattca cgcgttgtgc tgtcactttg acatttcggc cgctgaccag
     3121 cgcgaatgcc ccttggagag gggcggtgcc gggaatgcgc ggggggtcgt ggaaagccct
     3181 tgcgcctcct ctgccgcccc cgaaacggac actgtttccg ctggtcagag gccttctgct
     3241 gaacccgccg ccggtgaccg gggccaccgg cggagaaggt ccgaaagaaa acctgcgtac
     3301 cgtcaccggt gtgtgaacat cacattgccc gccgtcgggc cgggaacccg tggccgcgcg
     3361 cggcgagcac gacggcgaac accggcacca gcaggagcag caccgtccag gggaaggaac
     3421 cgctgccggt cgcgtccagc aggacgccgc ccagcacgcc gccgccggcc atggccacgt
     3481 tccacagcgt gacgagcatc gcctgcgccg cgtcggcctg gtcgccgccc gcgtcgccga
     3541 cggcggtctg cagcagggtg ggcagcccgc cccagcccag cccccacagg acggcggcga
     3601 cgtacaccag cgcgccgccg tcgctcagca ccgcgagaag ggcggcggcg gcagccacca
     3661 gcagggtgct ggcgatggtc agcgcgcgca gccggtactg gatctgggcg cccacgaccc
     3721 agatgctgag cagcgaggtg acaccgaagg cgagcaggac caggtcggtc tggtcgccca
     3781 tgcccaggcc gtccaggaag gtggcgatgt aggcgtacag caccgtgtgg gccagtacga
     3841 agacgagcgt gacgaagagc accgggcgca ctcccggcac gcccagcgcc cgcagcatcc
     3901 gcgggcgttc gccccgctgc tggcccgggt agtcgggcac ggcggcgacg atccacagca
     3961 gcagcaccac cgtgagcgcc gtcatcgaca ggaacgccac ccgccagccg agggcctggc
     4021 cgaggaaggt gccgacgggc acgccgaggg agagtgccac cggaatgccc gccatggcga
     4081 cggcgatcgc ccggccctgc agggggaccg gcgccatgcg ccgcgcgtag cccgcgagca
     4141 gggcccacgc caggccggcg gcgacgccgg cgaggaagcg ggccaccatc gtcaggccgt
     4201 agacggacga cacggccgtg accgtgttgg ccacggcgaa gcccgccacg gcggtgagca
     4261 gcagccgctt gcgccgccag ccggcggtgg ccgccgtcag cgggatcgcg gtcagcgcgg
     4321 tgccgatcgc gtagatcgtg accgtctgcc ccgtcgcgga ctcgctcacc cgcaggtcat
     4381 ggctcatctc ggggagcagg ccggcgggga gcgtctcggt caggctggtg atgaacaccg
     4441 cggtggccag ggcgagcagc gcgaacatcg gcagtttctg ccgcggctcc gcgctctccc
     4501 gccgcgtggg cgggacggtg ccggaggcgg cagcggtgtc gggtgaggcg ctcatggggt
     4561 cgtgtactcc gtatctggtg gggcgaggcc cgtgcggcac ggcgggacag gggggatccg
     4621 ccgtgccgcg gccgggcgtt cccggcagtc gggcatccgg gaggtacgac tgtgcgcgtg
     4681 gccacttcgg gaatgcttcg gaaagccttc gggaacgctt cggagccgga gcccgtgacc
     4741 gacagccggg cgcattacgg aacgggtacg gtggtgcaca tgcggttagg ggtgctcgga
     4801 ccactcgcgg tgtgggacga cgaaggggag ccggtccagg tccccgagac caaggtgcgg
     4861 gcgctgttgg cggatctgct cgcgcacgac ggcggccctg tctccgcgga ccggctcatc
     4921 gacgacctgt ggggcgacca gctgcccggc aatccggcgg gcgcgctcca ggccaaggtc
     4981 tcccagctgc gccgggtgct gggccgggag cggctgctgc ggcagccccc ggggtacggg
     5041 ctgcggctcg acccggccga cgaggtggac gtggagcggt tcggccggct cgtcgccgag
     5101 gcccgtgcgg tcgcggaccc gcgggcgcgg gcggacctgc tcaccgaggc cctcgggctg
     5161 tggcgggggc cggcgtacgc ggacttcgcc gacgaggagt tcgtccgggc ggcccgggag
     5221 tgcctggcgg aacagcggct ggccgtgctg gaggagcggg ccgaggcgcg cctggcggcg
     5281 ggggaccacc tgctgctcgc cggggagctg gccgcgctcg tggccgagca tccgctgcgg
     5341 gagcggctgc gcgcggtgca gatgcaggcg ctgtaccggt ccggccacca gggcgaggcg
     5401 ctcgcgtcgt acgaggatct gcgcacccgc ctcgccgcgg agctgggcgc ctgccccggc
     5461 cccacgctga gcgccctgca ccaggcgatg ctccgccagg acccgggcct ggacgccacg
     5521 gctccggcac cggtcgcggg cgccgggtcg tggtacgcgg gggcgtcgcc cgccgggtcg
     5581 ccgtacgccg gggcgtttgc cggggcgggc ggtgccgggc cggtgccggc cggggtgtcg
     5641 tacgccgggc agccgtacgg tgcgtcgccg tacgccgggg cgtcgccggc cgcggcaccg
     5701 aaccccgggc cggcgtatgg cgcgccgtcg cccgccgccg cgtcggaccc cgggtcgtcg
     5761 cccggtacgg tgtcgcccgc cgccctgtcg cacggggcgc ccccgtccgc cggaccctcg
     5821 ctcaccgcgt cgccggacgc cggcctgtcg gacggagagc cctcgcacgc cggcccgctg
     5881 cacggggcgc tcccgcccat cgagtcgccg ctcgtcaccg cgtcgccgtc cgcgcccccg
     5941 cccaccgcag cggcgccccc gcggtccgag gacggcgcgg tgccgacccc gccggccccg
     6001 tccgccccgc cgaccaacct gcccgtgccg ctcaccgccc tcatcggacg ggcggaggcc
     6061 ctcggtcggc tgtcccggct gctcgggcgg cagcggctgg tcacgctgac cgggcccgga
     6121 ggcgtcggga agacccgcct ggcggtggcc gccgcgcagg acgcggcggc ggggggcggg
     6181 gccgccgggc tgcccgacgg ggcctggttc gtggagttcg cgggggtccg cagcgccact
     6241 cctgacgacc tcgccgccat cgtcgccgcg accctcggca tccgggacga cgccccctcc
     6301 gccccgcccg ccaccggcac cggggccacc tcgcccgtgc accggctgac cgccgccctg
     6361 cgcgaccgcc gtaccctgct cgtgctggac aactgcgaac acgtcgtggc agccgccgcc
     6421 gagctggtcg cgctgctcct gcgcagcgcc ccccagctgc gcatcctcac caccagccag
     6481 gaaccgctcg ccctggccgg cgaggcggtg ttcctggtcg aaccgctgcc caccccggac
     6541 gccgtgcgcc tgttcaccga gcgggccgcc gcctgcgcgc ccggcttccg gctgggctcc
     6601 ggcgagcccg gcggcccgga cgggggtgcc gaccacgccg ccgtcgccga gatctgccgc
     6661 cgcctggacg gcatcccgct cgccctggaa ctggccgcga cccgggtacg cgccctgggc
     6721 gtccgggagt tggccgcccg cctcggtgac cggttccggg tgctgacctc cgggcagcgc
     6781 ggcgcgcccg cccgccagca gaccctgcgc gcgatgatcg actggagctg ggagctgctc
     6841 agcccgcccg aacgcaccgt cctgagccgg ctcgccgtgc accgcgacgg ctgcgacctc
     6901 gacgcggcgg aggcggtgtg cgcgggcgag ggcgtggccg gcgacgcggt gctggacctc
     6961 gtcacccggc tcgtcgagaa gtccctcgtc gtcgtcgcgg acggcccggc cggcccccgc
     7021 taccgcctgc tggagtccgt cgccgcctac gccaccgagc ggttgcacga gtcggccgac
     7081 gaggccgcgg cccgcgaacg ccacctgcac cactacctcg cgctcgccga acgcgccgag
     7141 caccggctgc gcggtccccg gcaacaggac tggctcgccc gcctggacac cgaggcgtgc
     7201 aacctgcgcg ccgccctgga cgaggcggtg cgccgggccg ccgcggggca cagcgcggaa
     7261 gccgtacggc tcgccaccgc cctgtcctgg tggtggctgc tgcgcggccg gctcaccgag
     7321 gcccgccgcg ccctggccgc cgtcctcgcc gccaccgccg gtgaccccga cccggaactc
     7381 gccctgctgc acagcgggtt cgtgctgctg accggtgagc gcacggtgac ctgcgacgcc
     7441 gacgccgtac ccgaccccgt gcgccgcgcc cgcgcactgt ggctgaacgc ctacggcagg
     7501 ttcagcgccg gcgacctgga cggcagccgc gcgctcaaca cgcgcgcgct catccacttc
     7561 gaggccgcgg acgagcagtg gggcatcgcc gccgcgctcg gcctgcgggc ggcgctcgcc
     7621 ctggtccgcg gcgacctgga cggcctggcc cgcgacgggc agcgcagccg ggccctcttc
     7681 cgcgacctcg gcgaccggtg gggcgaactg cagaccgtct caccgctggc cgcgctcgcc
     7741 gagatcaagg gggagtacgc gcaggcggcg caccgccagc acgaggggct gcagatcgca
     7801 cgtgagctga gcctggaggc cgaggtgtcg gcccggctgt ccgggctcgg ccggctcgcg
     7861 ctgctcgccc aggacttcga ccgcgcccgc gacctgcacg agcaggcccg ccgcatcgcc
     7921 gtcgaacagg gctacaagta cggcgagatc cacgccgaca tgggcctggc cctcggcgcg
     7981 cggcgcgccg gtgacatcga cgcggccgag gcgcacctgc tgcgcatccg cgacgcccac
     8041 gccgacgcct cctcaccggc cggcgaccac ctgctccacg ccgaactcgg cttcatcgcc
     8101 gaactccgcg gcgacgccgc cgaggccgcc gcccaccacc tgcgcggcct gtccatcgcc
     8161 cactgcctgg acgagccgcg tgccctcgcc ctctccctgg aggggctcgc cggcgcggcc
     8221 acgctgtgcg gacaccgctc cggcgccggc tgcgcggccc tgctgctcgg cgccgcccac
     8281 gccgcgcgcc gcagcgtggg cgcgccgctg ccgcccgccg agcgcggcga cgtcgaccgc
     8341 gtcaccgcgg cggcgcagga agcgctgggc ccccgcgcct tcaccgaggc gttcgagcgc
     8401 ggggcgtggc tgagccccgc cgaggcggag caccaggtac gcaccaccct ggccgcactg
     8461 gtggacaagg ccgcctgagc cgccccctcg gggggcaggc tcaggcgccg ccggtgccgg
     8521 agagggcggc ggaacccagg cccgccgacg cggtgctgat gatgccgtcc aggacatcgc
     8581 gggagcggac caggtcggcg atcatccggt cgagccggtc gcgttccgcg gtcagctcgt
     8641 cgacgagccg gggcgtcgcg ctcgcgctgg gtgtgccgtc gccgtcgcgc atgcagggca
     8701 gcagctgggc gatcttcttg ctgttcagtc ccgcggcgta cagcgcctgg atgcggatga
     8761 cccggtcgac ggcccagtcg ccgtactcgc ggtggccgcc cggggtccgc tcggaactga
     8821 gcagcccctg tgcctcgtag tagcgcagcg accgctcgct caccccgctg cgcctggcca
     8881 gttcaccgat ccgcatctgc caaccccctg tgccggaaag aggacttgaa tctcacaccg
     8941 gtgtcaactt ctagcgtagc ggtgcgacgt acatcgagcc gtctacggag gaagcaccca
     9001 tgagtgagct gaccggaaaa gtggcgttgg tgaccggcgg cagccgcggt atcggcgcgg
     9061 cggtggccca gcggctggcc gacgcgggag cggcggtcgc actgacgtat gtccaggcgg
     9121 aggaccgggc ccgcgaggtc gccaagcgga tcgaggagaa cggcggccgg gccgcggtcg
     9181 tccgggccga cctgacccgg ccgaacgacg cggccgaggc cgtggagcag accgtgcgcg
     9241 agctgggcgg catcgacatc ctggtgaaca acgcgggctt cctcgcctac ggcccgctgg
     9301 acgaggtgac ccccgagtac ctggacaagg tgctcgccgc cgacgtccgt tcggtgttcc
     9361 tcgccgccca ggccgccgcc cggcacatgg gcgacggcgg ccggatcatc agcatcggct
     9421 cgtgcttcaa cggccgggtg cccgccggga acttcgtcct ccaggcgacg gccaagaccg
     9481 ccctcgtcgg gctgaccaag ggcctcgccc gggagctggg gccgcgcggg atcaccgcga
     9541 ccatcgtgga cccgggcccc atcgacaccg acatgaaccc ggccgacggc gactccgccg
     9601 agtggcaggc ctccctcacc gccctcgggc ggtacggcga ggtcgaggac atcgccgccg
     9661 cggtggccta cctggcggga ccggccggcc gttacatcac cggcaccgcc atcgccgtgg
     9721 acggcggcta caccgcctga cggttccccg tccgccaaga cggcctcgca ccccgccccc
     9781 gccggccccg ccggcggggg cgttctttca ttccgctgaa acaacaagcg gttcccggaa
     9841 ttgtccaagc cggagaatca ttcgcacttc ttgccgggcg tgacattcgc tgacagccct
     9901 tgacacagct ctgacagagc gagcatcgct tctttgcaca aggtcgcgca gcatgttcgg
     9961 tgtcgaaaag gaagcaggct ctggaaaagg agggaacgca atggctgaat cagcgaacga
    10021 ggcaagcctt ccgcagccgc cccatctgtc cgacgcgacc ctgcgcgact ccgcccacat
    10081 gggaggtgtc gaattcggtc ccaaggacgc caccgtcatc tccgagctgt tggtgaagac
    10141 cggaatcgac ctggtcgagg tcggcatggt ctccggcccg aactccaagg acgccgacct
    10201 ggtcctcgcc acccacgagg cgatcacccc cgagcgcagc atgacgctcg tggtggtgcg
    10261 cgaccgcgag caggtcaaga aggccctgga cgaggccgag cggctgggcg tgcggcacat
    10321 catgtactcc atccccacct ccgagcagca cgccaagctg aagctcggct cgcccagcgc
    10381 gaagttcctg aacgtgctgg cgcgttcggc gatctcgcag gccaaggagc gcgggttcca
    10441 cgtcaccttc agcggtgagg acggcgcccg cacccccaag gagcggctcg tcccctacgt
    10501 caccgccggc ttcgaggccg gggccgaccg gttccggctc gcggagaccg tcgcctatct
    10561 gtcgccctgg cagatggagg aggtgatcgc cgacctcacc gccatcgacg gctccgagat
    10621 cgagatccac tcgcacaaca tgctgggcat ggccgtcgcc aactccctcg ccgccgtccg
    10681 cgccggtgcg cagtggatct cggcgaccgt cggcggcatc ggcgagcgcg gcggcaacgc
    10741 cccgctggcc gagctgctca cctcgctgcg cgtcgtctac ggcgacaccc gcttcgacct
    10801 gtcccacctg acggagctgt cccgggtggc cctcaagggc gccggcctcg gcagcgcctt
    10861 ccagtccggc ccgacgaccc cgcacgcctt cgcctacgag ctgccgggcc agctcagcca
    10921 ccccgaggcg tacgagacgc tgccggccga actcgtcggc aacacccggg agctgcgcgt
    10981 gcgcacccgg ctcacccccg ccctcgtcag gtgggcgctc gccggcgcgg acatcgacgt
    11041 cgacgtcgag gacttcaccg cctggctcat cgagcggcag gagcgcaacg gcgcccccgt
    11101 gctggaccag gaggcggtcc gcaaggccgc catcgacttc caggccgcct gagcgcgtcc
    11161 cgcctgtccc gggccgcctg agcgcgtccc gcctgtcccg ggccgcctga gcgcgtcccg
    11221 cctgtcccgg acggctggag cgcgcccgcg ccctccgggc cgcgccccgc gtcgccctcg
    11281 tccgaactct cacctctttc ccgtacccgt caccgtgatc ggagtccttc catgagcacc
    11341 gctgttctca ccggctcgtg ccccgagtgc gagaccgagc tgaccgtgcc cgagatggtc
    11401 gagggcgaga ccctctcctg ccccgagtgc atgctcacgc tgcgcatcga gggcatcagc
    11461 gacggccggc tgaccctgca gatggtcgag gtccagctgc gcgactgggg ccagtgacat
    11521 gaccaaccga gtcgccgtcg tcgcggaccg ggtcggctgg gaggaacgcc ggctgatcga
    11581 gaccgcccag gacttcggcc tgcgcttcga ctgggtcaac gacgagtccc tgtgcgccgg
    11641 tcaccgcgac gccctgtccg tcaaggacta cgacgcgctc atggtgcgca gccgcagcta
    11701 cacccggggc ggcctgatcg ccaccctcgc cgaggcggac ggcttccgcg tcctcaactc
    11761 cgccgccgcg atccactcct gcgagaacaa gctggtgctg cgcgccgtgc tgcgcgaggc
    11821 cggcgtcccg gtgccggagt tccggctcgc cctgtcccgc aaggacttcg agaaggccct
    11881 cggcgaactg ggcgtaccgg tcgtgctcaa gccggtctac ggcggcatgg gcaagcgcgt
    11941 gaccctggtc cgcgaccccg acctggcgca ctccgtctac gactacgtcg aggacctggg
    12001 ccacgccttc gagcaggcct gcctggtgga gccctacctc ggcggcgggt cgatccgctg
    12061 cctggtcgtc ggccgggaga tcgtcgccgc cgccgagttc gagagcgcgg gcaccgactg
    12121 gcgcagcaac gcggccctgg gcaaccagag ccgggcgctg gcccacgacc ccgacgtgca
    12181 gaagatcgtg gacggcgtcg tggaccggct cggcagcggc atctacgggg tcgacctgtt
    12241 caagaccccg tcgggctatc tcgtcaacga ggtcaaccac gcccccgcct ggcggggagt
    12301 ggcatcgacg accggggtcg acatcgcgtc ggtcgtcgtc cgttacgtcc aggagacact
    12361 cgaatgatcc gtgtgggaat agtcggcgcc tccgggctcg ccggcggtga actcatcagg
    12421 ctggtcaacc agcatcccga gctggaactg accttcctgg gcggcaactc cagcgccggc
    12481 cggcggccgg ccgaactgca ccccgggctc cggctcgacc tgggcctgac cgtcgagccc
    12541 gtcacggccg accgcgtggc cgaacggtgc gacgtggtgt tcctcgccac ccccgccccg
    12601 gtctccgccc ggctcgccgc ggaactcgcc gaccgcgtcc cgtgcgtgac cgacctcagc
    12661 ggcgccttcc ggatccgcac cccggagctg cacgaacgct ggtacccgaa ggccgagcgg
    12721 accaccgagc tggccgaccg cttcgtctac ggggtgccgg aactcgtcgg cgaccagctc
    12781 gtggacgccg cgctgatctc ggtccccggc tgctacgcca ccgccatcac cctggggctc
    12841 gcgccgctga ccctcgggct cggcctgaac ctgcgcacgg tggtgatcga cggcaagagc
    12901 ggatccagcg gcggcggtct gcaactgcgc gtgccggacc tgcacccgct gcgcaacggc
    12961 gccatcgcgc cgtacgcccc caccggccac cggcacgccg ccgaggtcag cgacttcctg
    13021 ctgcgcagca agcccggcag cgtcggctcc ctggccatgt cggcgtacgg ggtgtcgcat
    13081 gtgcgggggc tgctcgccag cacctacgtc tacaccgacg accaggtgga ccagcgcgaa
    13141 ctccagcgcg cctacatcaa gttctacaag gagcacacct tcgtccgggt gcgccgccac
    13201 aacgagaccc tcatcccggt gcccgacccg caggccgtgc tcggctccaa ctactgcgac
    13261 gtgacggccc tgcacgaccc ggacggcggc cgcatcgtcg tgctcgccgc cctggacaac
    13321 ctggtcaagg gcgccgccgg gcaggccgta caggcagtga acaagcgctt ccgcctgccc
    13381 gaggacacgg gcctgaccat gcagccggtg atgcccgcat gaccgagaca caggcacagc
    13441 tccccccgac cgtggtcaag ctcggcggca gctgcctggc cgacctggag ggcggctggt
    13501 gggacgacct ggcggcgcac ggccgggagc ggcccctgat cctcgtccac ggctggtcca
    13561 agccgctgaa gcagctcagc ccccgctaca gcgagccgtc ggcgatcctg cgcgaccggt
    13621 acggcaacca gagccgctgg accacgcccg aggtcatcgc cgacatcaag accgtcagcg
    13681 ccgacctggg ccgggaggtc ctgcaacggc tcacccggcg cggcatcacc gccgaacggc
    13741 tgctcggcag cgacgggctg gtcagcgccg gcgcgggcga gcgctggtgg tggaaggaca
    13801 agcagctggt cgagctggag aacctggtcg gccccatcac cggggtggac ccggcgccgc
    13861 tgaccgggct gcggcccggc cacgcctacc tcgtcacccc gctggcccgc aacgacgcgg
    13921 gccaggaggt gaacaccgac gccgaccggg ccgccgccgc catagccggg gccaccggcg
    13981 ccaccgacct gatcctcgtc accgacgtcg cgcacctgct gatcgacggc gagccggtgc
    14041 gcgagatcac cgctcagggg gcggcggagt tccgcgacaa gggcgccacc ggcggcatgc
    14101 gcaagaagct gcgggccgcg ggcgaggccc tggaccgggg cgtggagcgg gtcgtcatcg
    14161 gcagcgcgcc cgtcacggac ctgctcgccg cccgcaccgg caccgtcatc acccgaacct
    14221 gaggagcacc gacgtggcga aaacccgtgt gctggtcgtc aacaaccgca ccctgtccct
    14281 gaaacagctc cgcggacgct tcgaagcgct gggctcggac accgacaccg tcgacgcggc
    14341 gtccgtgccc gcccggctcg acggccgcta ccaggcgatc gtgctgagcg gcaccaaggt
    14401 gcgggcctac gaccaggagt actacaagcc gctcgtggac ctggtcatga acgccgacgt
    14461 cccggtcttc gggatctgcg gcggcatgca gatcctcgcg gtggcgaacg gcgcgcagct
    14521 ggccgagggc ccgcagcggg tcggcggcta cgaggtccag gtggacaagg aagagccgct
    14581 gttcacccat gtgaaaccca ccgtgacggt cttccaccgg cacaccctct atctgaagga
    14641 ggccccgaaa ggcttccgct ccatcggccg ctccgagcac gcgcccgtgg agttcctgcg
    14701 ctccgacgac ggccggatct acggatcgca ggcccacctg gagttccgca gcgacggcct
    14761 ggagatcctg cgcggcttcg cacagctcta ccagtgaacg acacctcacc caccgatggg
    14821 agcacttggc aatgagccct gttgacgaca acacccagga tcccgcgctc gtcgtgcacc
    14881 tgaacggcag cggcggcacc atcaagagct gggtcgtgat cgacacgctg gtcgacggcc
    14941 tcgcgatggg cggcgtgcgg atgaccccgg gggtcaccca ggaagaggtg gccggcctcg
    15001 cccgcgacat gacgcacaag ttcacgctcg cgggcctgcg gatcggcggc gccaagggcg
    15061 gcatcgtctc cgacggcagc aaccgcgagg agacgttccg caccttcgga cgcaccgtca
    15121 aaccgctgct gcacggcggc atccacctcg gcatcgacat gggcgtcacc cccgccgacc
    15181 gggccgtctt cttcgacgag gcgggctacg acccgcgcta ccggctgggc gccccggaca
    15241 tgccgatcga ctggcgcacc tactacgagc cgctcatcga cgtcaccggg cacggcgtcg
    15301 gcgtcgccgc cgtcaccgcc ctggaggcga gcggccgtac cgagcccgcc cgggtcgtgg
    15361 tgcagggctt cggcgcggtg ggccgcgcgg tcgcccggtt cctcgaggac cgcggccaca
    15421 ccctcgtggg cgtcgcggac gcgcagggca ccatcagcgc cgaccggctg cccgtggccg
    15481 acctcgtcgc ggtcaccgac gagttcgggc tcatcgaccg ctcccggctg ccgcagcacg
    15541 tcaccctctc cgacggcccg gacgcctggc tcgacgtcga cgccgacctg ctgatcctcg
    15601 ccgcccagaa gcacgcgctg aacgccgaga acgcgcaccg gctgcgcgcc ggcctggtgg
    15661 tcgagggcgc caacctcgcc tcggacgcgc aggcgcggga gaaggcgcgg gcggccggcg
    15721 ccaccctggt gccgggcgtc atcgccaaca tcggcggcgc cggcgcggcg gccctggccg
    15781 tcacccgggt cgtccccttc gagctggccg ccgaggcccg caaggcctgg gtcttcgact
    15841 ggatcggcga ccgggtgcgc gacaacaccc gggccctgct ggagatcgcc gccggacgcg
    15901 ccggcgaccc gctgcccgag ctgctctcgg tacgacgtgg agaactccga tgacgaccat
    15961 ggttcccccc gcacacatac cggcgccggc cacggaccgc gcggccgagt accggtcgcg
    16021 cggctggtgg cgggacgaga cgttcctcga cgacctgcgg cggcaggccc ggatacggcc
    16081 gcgcaagctg gccgtcgccg ggcgccgcct gggcgaggcg cgtaccgaca ccctcgacta
    16141 cgcggaactc tccctcctca ccgaccggtt cgccggagcg ctgctcgaac tcgacgtccg
    16201 gcggggggac gtcgtcgcgg tccagctgcc caaccggtgg gagatggtcc cgctgatgta
    16261 cgcctgcatg gccgtcggcg ccgtcatctg ccccatcgca cccgagtgcc agggcgagga
    16321 actgcgccac cgcctccaac tcaccgaggc ccggctgtgc gtcaccgtcg ccgagtacga
    16381 cggacatccg ctcgcccggg acatcgccgg cctgcgctcc gcgctgccgc tggagcacgt
    16441 ggtggtggtc ggcggccacg ctcccgaggg cacgctcgac ttccacgacc acttcgtggc
    16501 ggtgccctgg gaggacgcgc acatgggcga cctggagggc cgcgccctcg ggcccgacga
    16561 gccgttcgtg gtgctgttca cctccggcac gaccggcttc tccaagggcg tcgtgcacag
    16621 ccagaacacc gtccactcgg gcgtgcgcgg ctatgtggac acgttcctgc tccgcgacga
    16681 cctggtggcc gtcgtcacca cgccgctggt gcactactcc ggcttcggcc agggtgtcct
    16741 ggccggcgtg atgctcggcg ggacgatcgc cttccaggac ggcaggaacc acaccagcct
    16801 gctggacctg gcggagcggt acggcgccac cctgctgtac ggtccgccgc ccacgctctt
    16861 cggtgtggcg gcggcccagc gcgccgaccg gcacgacgtg tcccggctgc gctacacgat
    16921 caccggcgcg gcaccggtgc tccaggagct ggtggacgag ctgcgcgaca ccttcgacac
    16981 cgccacctac tcggtgtggg gcatgtccga gttcggcccg atcaccatca gccggctcga
    17041 ctacgaccag aactggtcgg cgcacagcca cggccgcccg atcgacgcca tggagatccg
    17101 catcgatctg tgcgacaacc ccgacaagcg ggccccggtg ggccggctgc gggtgcgcgg
    17161 cgcctcccag gcgctcggct actaccgcaa ccaggacgcc ttcgacgccg aactgaccgc
    17221 ggacggctgg ttcgacaccg gcgatgtggc gcgcgaggac ggccgcggcg gcatccgggt
    17281 cctgggccgg gccaaggacg ccatcctgcg cgacgggatc gtcgttccca tggccgagct
    17341 ggaggcgatc ctctccgcgc acccgaaggt cgccgaggcg acgctggtcg ggccgaccgg
    17401 gcggacggac gactccgtcg tggccgtcgt cgtaccccgc ggcggcgccc ggcccacgct
    17461 gcgggagatc cgggagcacc tgctcgaccg cggccaggac ccccggttcc tgccggaccg
    17521 gctcgacctg gtcgaggccc tgcccaagac cctcaccggc aaggtcaaga aggccgaact
    17581 ccggcggcgc ctcgccggag cctgaccgcc tcgtgcccca cggcgcggcg gcaccgcccc
    17641 agggcggtgc cgccgcgccg tcgcgtctgc ccggccggct acatcccgta gctgtcggcg
    17701 atcagggaca gcgacgtgag ccgttcctga aggccgtgcg cgttggaggc gagcatgagt
    17761 tcgtcggcct gcgtccgctt ccgcagctcg cccagccgct cccgcaccac gtccggggtg
    17821 ccgtgcacgg cgtgctcgag ccagccgccg aggatcttcc gctcgtacgc ggtgaacaca
    17881 tgggacctgg cctcctcggg ggtcggtacc agccccgggc gcccgctgcg gaaccgcacc
    17941 gtggtcagcg ccccggtgag cgcctggtcc cgggcctgct cctcggtctc cgcggcgaac
    18001 gcgaacacgc ccacgacggt gtacggctcg gccagcacgg gggagggacg gaacgactgc
    18061 cggtacagct ccagcgcggg gaccgtgtgg tggcccgcga agtggtgcgc gaaggcgaag
    18121 ggcagtccca gccggccggc cagctgcgcg ctgaacccgg acgagccgag gagccacacc
    18181 gcgggccgcc cgcccgaggg cccctgcacc gggccgggta cggcgtgcac ccggcggtac
    18241 ggatgcccgt cggggaagtc gtcgtcgagg aagccgagga gttcggcgac atcggccggg
    18301 aacgtgtcgc ccgtagccgg cccgtgggtc cgccgcagcg cccgggcggt caactggtcg
    18361 gtgcccgggg cgcgtcccag cccgaggtcc acccggccgg gggccatcgc ctccagggtg
    18421 tggaactgct ccgcgacgac cagcggggcg tggttcggca gcatgacacc gccggaacct
    18481 agccggatcc gggtggtctg cgcggcgagg tacgccagga tcaccgcggg gctgctgctg
    18541 gcgatgccgg gcatcgagtg gtgttcggcg acccagtacc gctggaatcc gcgggcttcg
    18601 gccaggcggg cgagccgcgc ggaggtccgc agggcctccc gcgtggtgtg gccctctccg
    18661 accgctacca ggtcgagaac ggacagggcg tcggccatcg ttgctgtccc tccgtagtcg
    18721 cgcacgggtg cgcgttccgt catgaaaaag ggcccgggcc gggtgtgcgg gggaggtgat
    18781 cccgcacacg accggcccga gcgcctcaga aggtcccggc tcggctactt cggggccgcc
    18841 gccccgtacc ggacctcgtt cgccagcacg acaccgtggc tggacacgtc gatgaccatc
    18901 cggtcaccgt tctcgatccg gaacccgtcg tggtacgtcg ccttgtccgc gccgaggaac
    18961 aggtagttga ccaggcccgg gcggcgcagc agcgggtgcg cgaacaggtg gtccgccatg
    19021 tccgggatcc ggtggaagag ggagtcggcg ccgcacgaga aggggccccg ccacgcctcg
    19081 gcgccgtccc gctcgatggt gacgctgccc gtgaccgtct ccggcggggt gtcgaggaac
    19141 agccacggcg tgatcgaggt ctcgcacagc ttggcgtacg gggtccacgc ccacgggttc
    19201 ttcaggtgca ggccgatgtc gttcaggtcg ttgccgaagg tgtagccggc gtagtgcgga
    19261 accccctggt cgtcgttggc gtacaccagg acgacctcgg gttcctccag cagccagacg
    19321 gggtcggccg gggtggtcag cggctcgtcc ggcatccgga gccaggaacc gaagcccttg
    19381 atgtagtagt tcggcgcggt gaactcctcg tcgggttccg gggcgcggtc gaacttggag
    19441 cggtgcgtgc ccatgaaccc gttgatcagg gcgttgttgg aggcggtcgg cagcagcggc
    19501 ggcaggaacg tcaggccggc gtcgccgggt tccacctcga tccggccgtc cagcccggcc
    19561 agggcggacc gcaggccctc ggggccgccg cccgcgacga gggccgcccg cagctgcccg
    19621 tcggtcaccg ggtacagggt gagggggctg ccgggcaccg gcaggccgtg gcccgcgtac
    19681 cgacggccct ggtatgtgca ctcgaagatg atggacatgg ctgtcaggtc tcctcaggag
    19741 ttggcggatg agcggggggc cgggaatccg tgggtgcggg aggcgagcac gatggcgagg
    19801 accgggacca ggaggatcag caccgtccag gggaaggcct cggcccccac ggcgtccagc
    19861 agcaggccac cggcgatgcc gccgccggcc atcgcgacgt tccacagggt gaccagcatc
    19921 gcctgggccg cctcggccgc ctccccgccg gcctgaccgc ccgcggtctg cagcagggtg
    19981 ggcaccccgc cccagccgag cccccacagg gcggcggcga cgtagaccag ggcgtcgctg
    20041 ccggagaacg cgcccatgac cgcgacggcg acgccgacca gcagcgtgct gacgatggtc
    20101 agggtgcgca gatggcggtg gatgtacatg ccgacgaccc agatgctgat caggcaggcg
    20161 acaccgaaga cgagcagggc cgcgtccacc tgggcgccca tgccgatgtg gtcgaggaag
    20221 ctggcgatgt aggcgtacag gagggtgtgg gccaggacga agaccagggt gacggtcagc
    20281 accgccgcga cgcccggcgc ccgcagggtg ctgcgcatgg ggatcttgcc gccggcctgc
    20341 tgaccggggt agtcgggcgc cacggccgcg atccacacga gcaggaccac ggtcagcgcg
    20401 gtcatcacga ggaaggcggc ctgccaggag accacctgcc ccaggaaggt gccggccggc
    20461 acgcccagtg acagggcgac ggggatcccg gccatggcga tcgcgagggc gcggccctcc
    20521 tggtgcgggg cgaccatccg gcgggcgtag ccggccagca gggcccaggc caggcccgcg
    20581 gcgaccccgg cgacgaaccg ggcgaccagg gtgagcgggt agttcaccga cagggcggtg
    20641 acggtgttgg cgacggcgaa gccggccatg gcggtcagca gcaggcgttt gcggtgccag
    20701 cccgcggtgg ccgcggacag cgggatggcg gtgagcaccg tccccagcgc gtagatggtc
    20761 accgtctgcc cggtggccga ctcgctggtg tgcaggctgg cactcatgtc gggcagcagc
    20821 ccggcgggca gggtctcggt gagactggtg atgaacaccg cgacggccag ggcgagcagc
    20881 gccgccatcg gcagcttccg ctcggcggtc gacgcgtcgt cgggtacggg gacggaggtg
    20941 gcggtgccgg tggacggctc ggcgcttgtc atgatgggtg ccttcgaggt gagggtcgag
    21001 cccggcgtgg aagggtcctc ccggggcggg gacggtcagg cccgcaggac gcgggcgccg
    21061 gtgagatcgg ccagcgcggt gtcgaactgc tccaggtacc ggcggatcca ggggagttcg
    21121 agcgggtccg gcgccgtgag cgcggcggtg cgccgctcgt cgtcctcgcc gtacagccgg
    21181 ctggtcgcga cccggatccg cagggggtcg cccaactcgc cgaaggcacc ggccgggagg
    21241 acgcccacgc cgtgccgctc accgaggaac cggaccaggt cctcgccgcc gtgcacgccg
    21301 tgggcccggg ccaggtggtt ccggagcggc ccgaagtccg ggtagaggta gcaggtcgcg
    21361 cggaccggag cgacccgcgc accggcggcg gtgagccggc cggccaccgc gcgcaccacg
    21421 atctcgtgca gccggcggct ggccgcgacg cgctcggtga cctccggtgg ctcgccgaac
    21481 gcgtaggcgg cggcggcctg caccggcgcc ggcgggctcg accagatctg gctggcgacc
    21541 gagaccagac ggccgtgcag cgcacgcccg atgccgctgt ccggaagccg ggccacaccg
    21601 gtgcgccagc cgccgacggc caggttcttg gtgagcccgg tggtgacgac ggtgcgctcc
    21661 ggggcgtgcc gggccgggga ctcggcgggc accgaggtgt cgtagacgag gtcgcagtag
    21721 atctcgtcgg agacgatgac gaggtcgagt tcccgggcca gggcagccag gcggtgcacc
    21781 gtgccgggcg aggcgagggt gccggtcggg ttgtccggca gggtcaccac cacgcaccgg
    21841 gggtcccggc cggcggcccg cgccgcggtg acggccgcgc gcagccgctc cgggtcgggc
    21901 actccgccct ggcccgcggc gatcggcacg gggacgggac gtgcccccac gagccgggcc
    21961 tgggcggcgt agctgaccca gctgggtacg ggcaccacca cgtccccgcc gacggcgagc
    22021 agcagcgcga acagcagcgg cttgctgccc ggcccggcca cgacgagccc gggatcggtg
    22081 gcgaggccgc gccgctccca gtacccggcg gccgaggcgc gcagggcctg gctgccgggc
    22141 acgggaccgt acgcgttcgc gtccgcggcg gcggcgagcc gccgacgcag ctcgggaagc
    22201 acgggcaggc cgatctcccc gccggccatc ggcagcacct gttccccggc ccggcgcctg
    22261 cggtccaggg cctcatcggc ggccagggtc gccgacatgg gtatggacgg ggcatcggac
    22321 atgctgtcac tgcccccagt cgcgcagctg gacctcgacc atctccaggg tcagccggcc
    22381 gtccgcgatc tcctccacgc ggagggtcag catgcactcg gggcaggaga gcgtctcgcc
    22441 ctggacgatc ggcggaacgg tcagttcggt ctcgcactcg gggcaggcgc cggtgagggt
    22501 ggcgctggac atggatcaac tccgttcgtc gggctgcgta acggtgcact accttccaac
    22561 gcgcctcgga aaagagtaaa ggcggtcccg tcaattctct gtagtggatt gtcaagaagt
    22621 gtcaagacgg aaaggagttg caagattggc ctggcggaat gtcaagtccg ccggattgcc
    22681 gcagcagttg ccctgaccag caactaatct gccgccatgg acatttttcc gctgcctcgc
    22741 ctcgggctgg tcgtaccccc ggaaaacccc ctggccgaac cggagttcaa ccgtctcgtc
    22801 ggcgccgagc tgaatgtgta cagcgcgcgt ttcccgctga ctcccggaat gggggtgaag
    22861 gagacgatgc tgaggtacaa cgatgttctg gaggacaccc tcggcacctt cggccgcatg
    22921 cgtctggacg ccgctgtggt cgcgtgcaac gcgtcgcact atctgctggg cccggagggc
    22981 gaccgcgctt tcgtcgccga actgtcggaa cgcttcggct accccgtgca gtcgacgacc
    23041 caggccatcc tcgcggtgtg cgagcaattc gggatttccc gtctgacgct cgtctccccc
    23101 tactgggact ggctgacgga gacgtcccgc gccttctggg agcaggccgg cgtcacggtc
    23161 gaccgtgtcg tcctcgcccc ggccgtgccg ggcgagaagg acgaggacca cgagttcgac
    23221 ccgtaccggg tgacgacccg cacgctcctg gagcggatac gcgccgccgg cctgcccgac
    23281 gagggggccg tcctcttcac cggcaccggc atgggcacgc tggccgccct ggccgaactc
    23341 gaccgcgagt tccgccgcac cacgctgctc acgtccaacc tcgcggcggc ctggtgggcg
    23401 cggcgcgcgg tgggggccgc cggcgccgag gtgcacccgc tccttgagcg cctggaacgc
    23461 ggcgcggcgc gctgagaccc cacggaaacc cttccctccc gatccgcagc ccatctccca
    23521 aggaggcgcc agccgtggcc accctcagcg aagcacagac gtccgatccg ctcgtggccg
    23581 tggtgagcgg cggcgcgtcc ggcatcggcg cggctgccgc agccgcgctc accgcccggg
    23641 gcgtgcgggt cgccgccctg gacctgacac ccgacgaggt ggccgcaccc gccgtcggca
    23701 tcgcctgcga cgtctccgac gacgcctccg tgcgcggtgc ggtggccgag gccgtggagc
    23761 gcttcggccg catcgacatc gtcgtcaaca acgccggcat cgccgcccag ggcacggtcg
    23821 ccgacaacga cgacgaggag tggcggcgcg tgctggacgt gaacgtcgtc ggcatggtcc
    23881 gcctggcccg cgccgcgctc ccgtacctgc gcaggtcgcc cgccgccgcg atcgtcaaca
    23941 cctgctccgt cttcgccgcc atgggcgtgc cgcggcgggt cctgtactcc gcgtccaagg
    24001 gcgccgtcca ctccctgacc ctggcgatgg ccgccgacca cgtccgcgag ggcatccgcg
    24061 tcaacgccgt cgcccccggt gccgtcgaca ccccctggat ccagcgcgtg ctggcccgga
    24121 ccgccgaccc gcgggcggag cgggacgcgc tgaacgaccg ccacccgctg ggacggctgg
    24181 cgcgccccga ggaggtcggc gaggccatcg cctatctggc cgtcgacgcc tccggcacca
    24241 ccggcaccgt cctcgccgtc gacggcggca tccacgacct gcgcctgtga gacccgcgcc
    24301 ggaacgtggg acgacgaagc cccgccggga tcgtccggcg gggctcgcgc gcgcggcggt
    24361 cgggcggccg ggccgggtac ggctcgggcc cccgcgcctc gtcaggcggt accgaccggt
    24421 tcctccagca cgagcagccg gcgctggcag atgaggtagc cgagttcggc gcggctgcgg
    24481 ctgcccagga cctcggcgac cttcttgatg tgggccgaga ccgtacggga actcatgccc
    24541 aggcgggcgg cgatcgcttc gtcggtgtgg ccggtgacga ccatgcggag cacggcggcg
    24601 cggaccgagt cggtcaccag gtccgggcgg tgctgttcgg gggcgatcga gaccggacgg
    24661 gcgcgtgccc acgtgtggtc gaagaccttg acgaggaagg cgacggcgcc ggggtgccgg
    24721 acggcgagcg cggcgttctt gcgttccggg atgccgggga tgaaggcgac cgcgcggtcg
    24781 cagatgatga ggcgctcgaa cacctcgtcc acggtgcgca cttcggcacc ctcggccgtc
    24841 acgcgctcga tgtaggcgag ggtcggctgg tgggagcgga cactgtgctg gtagagcgtg
    24901 cgctgtgcga cgccgcgccg caggatcgcc aggtcgcgcg gcagggcctc ggcgagcagc
    24961 gcgggggacc ggccgccgcc cggctgcgcg gtgagcagtt cctccttgca cgcctccacg
    25021 accagccgca gggactggct gatcacgtcg gcgcccctga gggactcgat ggggactccg
    25081 gtgtcgtgct gtgcccggtg gtagaggctt tccgcggcca ggaacgagga ccgcagtgag
    25141 gccagcgtat tctcgtggtg ctcgatctcc cgcaccacgg agcgggagag ttccgcctcg
    25201 gcgactttcg ggggaatcgg gacgtacagt ccggcgacgc ccggaatggg gcgcagcagc
    25261 cggtagacga tgaggcattc gggaacgtcc cccgagatcg tcccgtcgtt gagggcttcg
    25321 cggtaacgct cgagcccgcg agcgcagaaa tgcacgccgg gcgatgttcc ttcgacgcgc
    25381 ttacggccgt cgcccttctc ctcgatgtcc tcttcctggc acatatgtcc caccttcgtg
    25441 ttggcgcgtt gcgtgatccc gacgcctgtc gccctcgcgt ccccgtccgc gcgtcagcat
    25501 cattgatgac gtggggggac gcggtcgagc gggtcctgcc aggcctttcg gcctggtccg
    25561 ggccgcgaat gatcatgacc gcccgcccgg cgggatattg ctaaacatgg aactactcac
    25621 actggcgagg tatcgaagat gtaccagact gcccggtacg gccgcgtctg caccgccctt
    25681 gtcgtgggta tcgcggcaac ggacgacgac tccgcctggg gttgatttca gccagtcagg
    25741 cggaatttag ccgtcgggga attccctgtt ccgtgttcca cgggatgtcc cggggatgct
    25801 cagggtgctt tccgtggttc ttccggtgaa atgagaggtt ttcccgaaag agtctcggta
    25861 tttcgccccc ggggggaaaa tttcaccgcg cacctgcctc ggggagggaa agaggtatgt
    25921 ccagcgagcg gtacgacgtg gtggtcgccg gtgcgggccc cgccgggctt ctcgcggcgg
    25981 ccctggtggc cgggcggggc caccgggtgc tcctgctgga gcggggcccc tgtccggggg
    26041 cgctgccggg cgtggtggtc cgtgagcggt ccgccgcggt caacgtggtc atcgagaacg
    26101 agcgggtggc cgggctgcgc caccgcccgg agggcgagcc ggcccgcacg gtacgggccc
    26161 gctacgtggt ggacgcctcg ggcggcgaca gcccgctgcg ccgtcatgtc gcaggagccc
    26221 ggggctcgtc cgggctggcc gtgtacgcct gcttcacggc cggcggcggg gcggcaggcc
    26281 cgcggcgctt cccgttcgac ggcggctggt tctggatcgc gccggccggt gacgggctga
    26341 cccgggtcgg cgccgtggtg cggccggacc tggcgggcct ggtgcgggcg gatcccgggc
    26401 gcgcgctgtc cggcttcgcc gaggcgtgtc cgccggtccg ggacttcctg gccggggcga
    26461 cccgggcgcg cggcggcccc ggcctcatcc gggtgcgccc gcactggtcg tacgccgacg
    26521 accggctgtg gcgtcccggg atggtgctcg tcggcgacgc cgcgtgcgcg gtgggaccgc
    26581 agtcgccgcc gtcccgcggg atgcacctgg cgtgccgcgg cgccggactc gcggccggcg
    26641 ccctcgacgg gttcctgcgg ggtgcggcgg acgaggcggc ggccttcgcg gagttcgaac
    26701 ggcggtaccg gacggcgtac gacgagaccc tgcacgacga ggtcctgcac gacgaggtcc
    26761 tgcacgacga tgccctcaac cacggcgccc ccgacggcgc ggcaccgcac ggcgaagtgc
    26821 cgcactgcga agaaccccac gagggcttgc cgttcggcga cggaccgcgc tcaccgctgc
    26881 ccggcctcag tcggtgacga ggtcgtccgg ggcggaccgg gccagttcgg cgagcctgcc
    26941 gagcgcctgc gccaggacct ccggctgcgg ggaggcgagg cccaggcgca cggcgttggg
    27001 ggcctggctg ccgccgacgg tgaacgcggc ggcgggcacc accccgatgc cgtgccgcgc
    27061 ggcggcggcg acgaacgtgt ccgcgcgcca cgggcgcggc agctgccacc agcagtggta
    27121 ggagcgcgga tggctgcgca cggcgaaacc gtcgaggtgc cgggccgcga tctcctgccg
    27181 taccgccgct tcccgctgct tggcgaccac cagcttcttc accgtgccgt cctgctgcca
    27241 gcggtgggcg gcctccagcg cgaagcgcat gggggaccag ccgcccgatc gcagggagac
    27301 cgcgatctca ctggtcaggg cggggggtgc caccgcgaag ccgagggtca ggccgggcgc
    27361 gatgcgcttg gacagggagt cgatcaggac ggtccgctcg ggggcgtagg cggccagcgg
    27421 cggcagttcg tcgcgcagga acgcccagat ggcgtcctcg accgcgggga gcccgagcct
    27481 cagcaggacc tccgccagcc gctcgatccg ctgctcgggc atcgtgagcg acagcgggtt
    27541 gtgcagcctc ggctgcacgt agacggcgtg cagcggggcc gccgcgtggg cctccgccac
    27601 ggcct
//
