LOCUS       NZ_AP024135            22163 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6173218
            Orig. end                         :: 6195381
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="23"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12163](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12163
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1200..1736
                     /locus_tag="K6K39_RS27200"
                     /old_locus_tag="EASAB2608_05566"
     CDS             1200..1736
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_05566"
                     /product="hypothetical protein"
                     /protein_id="WP_221334988.1"
                     /transl_table=11
                     /translation="MRARRSLALALITVTTALTAGCTDQETRETATGPGTTAPSWDGKA
                     PQEDALRRATRALNAVEPDGAARVDEGVEDLARGLDKTFSPKGDRPHTFDIACQAPADR
                     TLTLILARGDAETEWEVTCGDREADQFNIPAGGRFTARVPAAGRDTQGFVLWRLSTIAP
                     ADVEGCEDDIEGCEE"
     gene            complement(2039..2479)
                     /locus_tag="K6K39_RS27205"
                     /old_locus_tag="EASAB2608_05568"
     CDS             complement(2039..2479)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675691.1"
                     /locus_tag="K6K39_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05568"
                     /product="DUF6114 domain-containing protein"
                     /protein_id="WP_260335676.1"
                     /transl_table=11
                     /translation="MPDRPRRGPRLAFRGWRARRPFWGGLLLALGGGEILFTEKASLKV
                     VLHIGMQGLAGYLLPTLMVLLGLLILFNPSQRLFYSITGILLSLGTWLTSNLGGFFLGL
                     LLGALGSCLTFGWVPDQEPRVSRRKRRKRARALTSEGAQGTA"
     gene            complement(2485..3183)
                     /locus_tag="K6K39_RS27210"
                     /old_locus_tag="EASAB2608_05569"
     CDS             complement(2485..3183)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996942.1"
                     /locus_tag="K6K39_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05569"
                     /product="DUF6230 family protein"
                     /protein_id="WP_059253572.1"
                     /transl_table=11
                     /translation="MASSPDVPSTGNTPENSGSDTPSDTPNAAGSTAGGERRGRVRARR
                     AAVMAVPATLVAAGLAVLTAQGALGVQFAISGMPFTVTATELNGTGFEQFGGLDNMAEG
                     SPNAGDTGGQVLVVTSAIKQATLTKLCQSVDLGGTNLLITAGSGAEKVSATDLTTDSTE
                     LSGDAAFKNIEIGNDASTLTKAGVKGPIGVFSQQADTVRIAHLRQTNYATTAGVFKLPG
                     LKLRFSDSGC"
     misc_feature    complement(3364..3379)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.09"
                     /tool="antismash"
     gene            3827..4477
                     /locus_tag="K6K39_RS27215"
                     /old_locus_tag="EASAB2608_05570"
     CDS             3827..4477
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="K6K39_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05570"
                     /product="hypothetical protein"
                     /protein_id="WP_059253574.1"
                     /transl_table=11
                     /translation="MRTRSLLVLAGTATALALTWATPASAAGTVLTTGSTGGAAVAVGD
                     TLTAPLASGTSATFYSSATGTSGVKCTGSQFTAKVTANPAAPGTATESVTAHTFDSSTC
                     TSNVTGVLGVNGITINNLPYSATVTSDGTLTVSPPSGSVIQATVQLRTLLGTVTCVYQA
                     PKLTGKADNADSSINFTNQQFAKTSGSSLCFANGYFTAKYAPVTDAGVRVYVN"
     gene            complement(4496..5452)
                     /locus_tag="K6K39_RS27220"
                     /old_locus_tag="EASAB2608_05571"
     CDS             complement(4496..5452)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431988.1"
                     /locus_tag="K6K39_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05571"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_221335642.1"
                     /transl_table=11
                     /translation="MTRTTARPGVRVAAVAAPLLLLPWAAGPAQAHGAPTDPVSRVYAC
                     SPEGGAARSAACRAAIAANGAPFTAWDNLRVAGVGGRDRKVIPDGRLCSGNLPAYRGLD
                     LARRDWPATRLAPGGRLTLTYASTIAHTGTFRLYLTEQGYDPSKPLTWSDLPEQPFAEV
                     TDPPLRDGAYRVSATLPTDRTGRQVLYTVWQNSSTPDTYYACSDVVFPERGKAAGAAGA
                     ARPEASPSAPVAPSAPASQSSPTSPTPPASPAERAQRAAGESGERAGGTAADAAPVTEA
                     THGSGPSAPLLAGGATAVLLLTGGAALLFRLRRLPRR"
     misc_feature    complement(5763..5775)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    5840..5853
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.43"
                     /tool="antismash"
     gene            5895..6542
                     /locus_tag="K6K39_RS27225"
                     /old_locus_tag="EASAB2608_05572"
     CDS             5895..6542
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675696.1"
                     /locus_tag="K6K39_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05572"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_059253577.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIITAAADLFDRHGYESTSLSDIVAHAKVTKGA
                     LYFHFAAKEDLAHAILELQAKAAQQVVADAESRGCSSLEALMRATFGIARLAVEDPVPR
                     AGLRLATTDIAVRPPLRHPFTEWLDFATRKFTGAVREADVHGDLDTGAVAHSLVCFFIG
                     TRVAGRSLEPVGRLPRRVAEMWHLMIRGLVPVHRRPRYVTLATQLEREIRAA"
     misc_feature    5907..5909
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6565..7764
                     /locus_tag="K6K39_RS27230"
                     /old_locus_tag="EASAB2608_05573"
     CDS             6565..7764
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675697.1"
                     /locus_tag="K6K39_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05573"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_059253579.1"
                     /transl_table=11
                     /translation="MPDTPFAPVILGNEPGSFPHSVLAERHPAIIRQVREAFPYGPGQH
                     TALDELLKSCTQGTVEPLPGDAPDRDRWHGWGLTEYTGRSWYDVPWLWSESYFYRRLLD
                     AVGWFGPGAWQGIDPFRPFKRAELDAPETDEELAALDGLRDLPEEERARALLHGSLWGN
                     RADLGFRFSAAGAEAREPAPALVADDSETLWSLLPPGGTGTLVLVADNAGRELVPDLLL
                     VAHLLAEGRAARAVLHVKPYPYYVSDATTADVVDALHRLRAAPGQAAEYARVLWSALAD
                     GRLTVRAHPFSCAPLPYAAMPDDLRAEFAAATLTIVKGDLNYRRLVGDRLWPPTTPFRE
                     TTASFPGPVAALRTLKSDVITGLTAATEAALVAAEGQDWRTSGTHALIQVDPSGEVQRQ
                     "
     gene            complement(7741..9006)
                     /locus_tag="K6K39_RS27235"
                     /old_locus_tag="EASAB2608_05574"
     CDS             complement(7741..9006)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431984.1"
                     /locus_tag="K6K39_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05574"
                     /product="cytochrome P450"
                     /protein_id="WP_221334989.1"
                     /sec_met_domain="p450 (E-value: 1.3e-17, bitscore: 62.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPEAPPVPDVFDPRRYATAVPYDDYRVLRDRHPVAWQEEPEVL
                     GWPAGPGFWAVTRHADVVRVLKDAGTFSSYAGATQIRDPDPEDLPFIRRMMLNQDPPAH
                     GRLRRLVSRAFTPGRVDRFAAVARERARTLLVRALAAAREGDGTVDLVAAVTDEYALLN
                     LADLLGVPASDRGLLLHWTQRVIGYQDPDEAGPPVLDGAGRPVNPRSPAMLRDMFAYAG
                     HLAAYKRRHPVDDIMTALAHDAELADAELEMFFFLLTVAGNDTVRSAAPGGLLALAEHP
                     EAYGLLRAGAVGVPSAVDELLRWHPPVLTFRRTAVRDTELAGRSIRAGEKVVVFHASAN
                     RDERVFADPDRLDLARSPNPHVSFGDGPHVCLGAHFARLQLRLLHEEVLRALPGPPRLA
                     GPAVRLVSNFINGIKSLPLHLA"
     gene            complement(9003..9848)
                     /locus_tag="K6K39_RS27240"
                     /old_locus_tag="EASAB2608_05575"
     CDS             complement(9003..9848)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-239). E-value:
                     1.3e-25. Score: 82.4. Matches aSDomain:
                     nrpspksdomains_K6K39_RS27240_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359590.1"
                     /locus_tag="K6K39_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05575"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_221334990.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.7e-18, bitscore:
                     64.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 8.3e-20, bitscore: 70.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFVLPHEVHGDGAHKVFAVHGWFADRSAYAAVLPDLDRTSFSY
                     ALVDLRGYGEARDAAGAYTTAEAALDLVELADRLGWERFSVIGHSMGGAVAQRLLAVAP
                     HRVRRIAGVSPVPASGMPLAGEQAALFTQAAHRAEHRRTIIDVTTGGRRPAAWLDRMVA
                     RSLERSDTKAFRAWLDSWAGEDFSADVAGSEVPALAVAGALDPALSPEVMRQTWMSWYP
                     RARLAVLPGAGHYAMDETPLELIRTVEDFLRADETEGADEAAEASGPRASGEAGAGGPA
                     "
     aSDomain        complement(9132..9788)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS27240_Abhydrolase_1.1"
                     /evalue="1.30E-25"
                     /label="K6K39_RS27240_Abhydrolase_1.1"
                     /locus_tag="K6K39_RS27240"
                     /protein_end="239"
                     /protein_start="20"
                     /score="82.4"
                     /tool="antismash"
                     /translation="VHGWFADRSAYAAVLPDLDRTSFSYALVDLRGYGEARDAAGAYTT
                     AEAALDLVELADRLGWERFSVIGHSMGGAVAQRLLAVAPHRVRRIAGVSPVPASGMPLA
                     GEQAALFTQAAHRAEHRRTIIDVTTGGRRPAAWLDRMVARSLERSDTKAFRAWLDSWAG
                     EDFSADVAGSEVPALAVAGALDPALSPEVMRQTWMSWYPRARLAVLPGAGHYAMDE"
     CDS_motif       complement(9558..9593)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS27240_0001"
                     /evalue="4.40E-04"
                     /label="NRPS-te1"
                     /locus_tag="K6K39_RS27240"
                     /protein_end="97"
                     /protein_start="85"
                     /score="12.9"
                     /tool="antismash"
                     /translation="VIGHSMGGAVAQ"
     gene            10001..12163
                     /gene="cyc2"
                     /locus_tag="K6K39_RS27245"
                     /old_locus_tag="EASAB2608_05576"
     CDS             10001..12163
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034221.1"
                     /locus_tag="K6K39_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05576"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_221334991.1"
                     /sec_met_domain="T1TS (E-value: 4.6e-80, bitscore: 269.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHLDEARAHSTQWAREMGMLEGSGIW
                     EQADLEAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMYKRTQDRAAGKAH
                     LDRLPLFMPLDLATPVPEPENPVEAGLKDLWARTVPSMSVDWRRRFSVATEHLLNESMW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSSGLVEYATAEVPAAVAGTRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGENSNGVLVLEKFFGCTTQEAADTVNDVLTSRLHQFEHTAL
                     TEVPAVALEKGLTPGEVAAVAAYTKGLQDWQSGGHEWHMRSSRYMNKGARSDSPWQLKS
                     GPGTSAAHIGALLASAAQERLRAYSHVPYQKVGPSRIPDLYMPFELQLSPHLDPARGNL
                     VDWCHRMGILQEGVWDEDKLAAYDLALCSAGLDPDATPEALDLSAQWLAWGTYGDDYYP
                     LVYGHRRDLAAARLTTARLSQCMPVEGEPTVVPGNAMERGLIDLWARTTAEMTADQRRT
                     LKAAVDTMTESWVWELSNQLQNRIPDPVDYLEMRRATFGSDLTLGLCRMGHGPAVPPEV
                     YRSGPVRSLENAAVDYACLLNDVFSYQKEIEYEGEIHNAVLVVQNFFGVDYPAALAVVH
                     DLMTQRMQQFEHVVAHELPVLYDDFQLSEEARAAMGGYVLDLQNWLAGILNWHRSVDRY
                     KAEWLGRRAHGFLPDRAPAVPALTFG"
     gene            complement(12235..12957)
                     /locus_tag="K6K39_RS27250"
                     /old_locus_tag="EASAB2608_05577"
     CDS             complement(12235..12957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010360991.1"
                     /locus_tag="K6K39_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05577"
                     /product="glutamine amidotransferase-related protein"
                     /protein_id="WP_059253585.1"
                     /transl_table=11
                     /translation="MTNTATLALVGDRSPHVVSHTRVPLLLEALAARDRLVLDAYWISS
                     QDAEAEGAVRGFDAVWVLPGSPYRSEAGVLAAVRTAREEGIPFLGTCGGFQHTLLEYAR
                     NVCGLTRAAHAENDPDATDPLIEALACSLVGHEAAVTIEPGSLAASVIGSARTVERYFC
                     AYGPSRHLDTLRAHGLRFSGRDEDGRVRVAELPGHPFFLASLFQPELAGDGSQPHPMVR
                     ALARAAVEHAASRAAQPV"
     gene            13051..13920
                     /locus_tag="K6K39_RS27255"
                     /old_locus_tag="EASAB2608_05578"
     CDS             13051..13920
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547156.1"
                     /locus_tag="K6K39_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05578"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_221334992.1"
                     /transl_table=11
                     /translation="MDPHLLRTYVTVARLASFSEAARELGYTQSAVSQHIAALEQDLGG
                     PLLTRRPVAPTAAGERLLEHAGPLLLRLDAARADILRMAAAPQHGLTLVTTATALGPAV
                     LGALPPAGVTLRVLTRAEIPAAVATGTADLGLVDGLAAPSDPLRLPDVAPLTARGVAEE
                     PVSVLLPAGHPLAGRPGLRLGDLRDARWLDAPDAGLPLAQLRAATAGGGAFRPALRYEG
                     TDVRTLTTLTAAGHGLTLLPRSAATAVPGTAAVPLTAPRLVHRTELLHGGSPGGAAAEV
                     VRRLANGR"
     misc_feature    14228..14248
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 18.96"
                     /tool="antismash"
     gene            14232..14795
                     /locus_tag="K6K39_RS27260"
                     /old_locus_tag="EASAB2608_05579"
     CDS             14232..14795
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657043.1"
                     /locus_tag="K6K39_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05579"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_221334993.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQERRDDGTAGPAHRPHAAPRRGRRLRAVLPAL
                     CAGIVLLFAGVGIGTVGATVIGMSRLAELQRQAPPPARPAEAGPTTAPAPAPAPPRATL
                     GLEAVDAEKAGAKVVGVHVPGPGYAAGLVRGDVVLHFGAARVDTAADLARAVARARPGK
                     AVLLTVRHSSGGYQQLAVIPGVVT"
     gene            15545..16672
                     /locus_tag="K6K39_RS27265"
                     /old_locus_tag="EASAB2608_05580"
     CDS             15545..16672
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191280.1"
                     /locus_tag="K6K39_RS27265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05580"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_221334994.1"
                     /transl_table=11
                     /translation="MTGSTPAPFTAADYRARMERAARSAADAGLAGLLVAPGPDMVWLT
                     GYTPTAVTERLTVLVLAPGRDPVLVVPTLEAPDAEQAAGATALTLRDWTDGKDPYAVTA
                     DLLDDRGRFGISDNTWAMHLLGFQRTLPDTSYASLTDALPMLRAVKDAAELELLAAAGA
                     AADATFEEIRKVPFAGRRESDVGHDLAGLLRRFGHSQVDFTIVGSGPNGANPHHEVGDR
                     VIQPGDMVVLDFGGLMNGYGSDTTRTVHVGEPTEEERRVHDVVRAAQEAGVQAVRPGVA
                     CQEVDRAARAVITDAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTATEDGGRRLNNTTREMVIVD"
     misc_feature    16680..16695
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.82"
                     /tool="antismash"
     gene            16726..17661
                     /locus_tag="K6K39_RS27270"
                     /old_locus_tag="EASAB2608_05581"
     CDS             16726..17661
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675704.1"
                     /locus_tag="K6K39_RS27270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05581"
                     /product="phosphotransferase"
                     /protein_id="WP_221334995.1"
                     /sec_met_domain="APH (E-value: 4.7e-15, bitscore: 55.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLKEGGDDTGGPDVRPVTEDREHTWWI
                     GSRHVLRLAPDREASLRRRRELRLRDLVRPHVPVAVPTSVAHGDWAPGLAYTLDTRVPG
                     GTADEYDVSAVGEADLAGLLSGLRTVLARQAEALGVPRVAPRSLDALRRMAVHAAERLA
                     AADEFDAARLHQLTQPGAAQLATQPGAAVLTHHGLTGAHVVVSADGRVRGILDWTAAAL
                     GDPAEDIAGLAVAVGSPAAVRAATLAGYGARPCLRGLWLARCDAVIRLTDHLEGRTGGS
                     LTLLRTQLRRAWEPILLERVTDFPEDEPEP"
     gene            complement(17864..19609)
                     /gene="treZ"
                     /locus_tag="K6K39_RS27275"
                     /old_locus_tag="EASAB2608_05582"
     CDS             complement(17864..19609)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675705.1"
                     /locus_tag="K6K39_RS27275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05582"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_086703345.1"
                     /sec_met_domain="CBM_48 (E-value: 0.00025, bitscore: 20.2,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 3.8e-11, bitscore:
                     42.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLHCEGTTRALARDPAREGWWTGEAEAADGAR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHGRHAWRAQWPGRALPGAVLYELHVGTY
                     TREGTLDAAAARLEHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPAALK
                     RFVDRAHELGLGVVLDVVHNHLGPSGNYLPRFGPYFTDTHTTPWGSAVNLDAPGSDEVR
                     AFLVGSALAWLRDYRIDGLRLDAVHTLYDTRACHFLEELSAAVDDLAAETGRPLFLIAE
                     SELNNPRFITPRAEHGLGLHAQWNDDFHHALHTALTGESQGYYADFARDPFAALAKTLT
                     GGYFHDGTYSSFRGRRHGRPLDRTRVAGHRLLGYSQTHDQIGNRAQGDRLSALLSPGLL
                     ACAATLTLTAPFTPMLFMGEEWAATTPWQFFTDHTDPELAEAVRRGRRREFASHGWAEE
                     DVPDPQDPATRERSCLDWSEPEREPHARVLAWYRRLIALRQEQPDLTDPDLADTKVAYD
                     ADARWLAFRRGDVRVAVNLGKEEAAIPLGTGRMEVLAAWEPVQAPGPDGLLQVPGESCV
                     VLTQP"
     gene            19787..20338
                     /locus_tag="K6K39_RS27280"
                     /old_locus_tag="EASAB2608_05583"
     CDS             19787..20338
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034232.1"
                     /locus_tag="K6K39_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05583"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_059253595.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDEERDKALRVLRDGVAMGRLSHDTFVRRME
                     LALAARRSDELAALVADLPRENRFSRAVLGTVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     GLGHPLRIGRDPANGLRLNHETVSRVHAELRHQGGLWVLKDLGSTNGTTVNGRRVVGAV
                     AVREGDQVAFGRMAFRLTAP"
     misc_feature    20359..20374
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    20431..20447
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            20447..20860
                     /locus_tag="K6K39_RS27285"
                     /old_locus_tag="EASAB2608_05584"
     CDS             20447..20860
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431953.1"
                     /locus_tag="K6K39_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_05584"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_059253597.1"
                     /transl_table=11
                     /translation="MTYLTRTAAAAGALLAAAGLLTAGPARAASHDLVPANWLHLTVTK
                     GDARSGDTRGALLLCDPPRGHARASEACAELAAVGGDIGRLPAADTFCPMIFAPVTAHA
                     RGRWDGRTVDFRETYTSACVMRARTGSVFTLDG"
ORIGIN
        1 tgcccgcggc gaggcccgcc gtgcccgcgg ccaccgccgt gcccgggccg gggcccgagg
       61 ggccggcgcc ggtgccgtac cggccgggga ggggtctgcc gccgtggccg tacgccgcgt
      121 ggctgccgta ggcgtcgcgg tgctcggtca cctggcggat ccaggtgtcc acctcggtgg
      181 gccagttgcg cgccggcgcg tcctcgtggg gcacgacgaa ccgggtcagc gcgtcgtgcc
      241 ccggtgcgta cggcccgccg cgcttgtccg cctccaggac gacctcgacg cccgtggggg
      301 aggcgaggaa ggtcagctcg atctcgctca ccgcgtgcgg gtaccgcggg gccggggtca
      361 gctcgatctg ctggtggaac ggcaaccgct ggcccgtacc gccgatacgg ccgtactcca
      421 gggcggccga gcggaagccg aagcccagcc cgccgagtgc ctccaggacg gcctcctgca
      481 cgggcagcgg gcggacggac agcgggtcca ggtagccctt gtcccggctg ccggccaccg
      541 cgacctccgt gcgcacgccc agcacgctgc cgagcggccg cccgtgcagc tcggtcaccg
      601 gggtctccca gggcagcggc acgctgaacg ccagctcccg ctcctcctgc ccgccgaggc
      661 ggaagccgcc gccgacggtg aaccgctcga aggcgaccgc gccctcgctc ccgccctccg
      721 cgtgctccgc ctccacgcgg gcgatcagct ccaggccgat gtgctcgacc tccacggcct
      781 caccaccgcc gcgcagcagc acccggcccg tcaacgcgcc gccgggcagc accgggccgt
      841 cgtccagcac cgtgtccacg gaggggccgc cgaccccggt cgcatccagc agcctcttga
      901 acaccatgcc gtggcccctt cgcccatcgc ctcgcccgaa cggcgctcca ccgccgtccg
      961 tctgcccggt gaactcgccg caacggcaaa gaagttccca agtcacctgt tcgggggacg
     1021 tgggggcccg gcggtctcgt caccggcggc ggcttcggtg cggacgggga aagggcgact
     1081 tgtccgtacg ctggtcggac ggccgggtga cgatccacgg caccgcacgg accgacgcgc
     1141 tggattgtgc gtacccgctc gccccgccgc ccgccgcccc ttccaccgac tggagtccca
     1201 tgcgcgctcg ccggagcctc gccctcgccc tcatcaccgt caccacggcc ctgacggccg
     1261 gctgcacgga tcaggagacc cgggagacgg ccaccgggcc cggcaccacg gctccctcct
     1321 gggacggcaa ggcaccccag gaagacgccc tacgccgcgc cacccgcgcc ctgaacgccg
     1381 tggagcccga cggtgccgca cgggtcgacg agggggtgga agaccttgcc cggggactgg
     1441 acaagacctt cagcccgaag ggcgaccgcc cccacacctt cgacatcgcc tgccaggcgc
     1501 ccgccgaccg cacgctgacg ctcatcctcg cccgcggcga cgcggaaacc gagtgggagg
     1561 tcacctgcgg agaccgcgag gccgaccagt tcaacatccc cgccggaggc cgcttcaccg
     1621 cccgcgtccc cgccgcgggc cgggacaccc agggcttcgt actgtggcgg ctcagcacga
     1681 tcgcccccgc cgacgtggag ggctgcgagg acgacatcga gggttgcgag gagtgagaga
     1741 ccaaggggcg tgcaggggat cggcgcgggc ggcacgccgg gcgacgagtg gagcggtggc
     1801 atccgcggcg acgcgttgcg gccgggctcg tggctgccac gggtgggccg gagccgcgcc
     1861 gaccggggcc ggagcactcc gtaccgctcc gcggtggccg gccgtgccgt acggcatctc
     1921 ccggacgacc gcacgcgagg cccgcgcccg gcccgcctcg ctcggggaga cggccgacgc
     1981 gccggcggca ccgacgtgca cctgacctcg cggttcgctc cggccggcga cctcgtcctc
     2041 aggccgtgcc ctgcgcgccc tccgacgtca gggcgcgtgc ccgcttgcgg cgtttgcggc
     2101 ggctgacgcg cggctcctgg tccgggaccc agccgaaggt gaggcagctg ccgagggcgc
     2161 cgaggagcag gccgaggaag aagccgccca ggttggaggt gagccaggtg cccagggaga
     2221 gcaggatgcc ggtgatggag tagaacagcc gctgggaggg gttgaagagg atcagcagcc
     2281 ccagcagcac catgagggtc ggcaacagat agccggccag gccctgcatg ccgatgtgca
     2341 ggacgacctt cagcgaggcc ttctcggtga acaggatctc gccgccgccg agggcgagca
     2401 gcagcccgcc ccagaacggc cggcgggccc gccatccgcg gaaggcgagc ctcggtcccc
     2461 ggcgtggacg gtccggcacg gcgatcagca gcccgagtcg ctgaagcgga gcttgaggcc
     2521 gggcagcttg aacacgccgg ccgtcgtcgc gtagttggtc tgccgcaggt gagcgatccg
     2581 cacggtgtcg gcctgctggc tgaagacgcc gatcggaccc ttcacgcccg ccttggtcag
     2641 cgtgctggcg tcgttgccga tctcgatgtt cttgaacgcc gcgtcacccg acagctcggt
     2701 ggagtcggtg gtcaggtcgg tcgcgctgac cttctccgcc ccactgcccg cggtgatcag
     2761 cagattggtg ccgccgaggt cgacgctctg gcacagcttg gtgagcgtgg cctgcttgat
     2821 cgcggaggtg acgacgagca cctggccgcc ggtgtccccg gcgttcgggc tgccctccgc
     2881 catgttgtcg agcccgccga actgctcgaa gccggtgccg ttcagttccg tcgcggtgac
     2941 cgtgaacggc attccggaga tggcgaactg cacgcccagc gcgccctgcg cggtgaggac
     3001 cgcgaggccg gcggcgacca gggtggccgg taccgccatc accgcggcac ggcgggcccg
     3061 gacgcgtccc cgtcgctcgc cgcccgcggt gctcccggcg gcgttcgggg tgtcggaggg
     3121 ggtgtcgctg cccgagttct cgggggtgtt gccggtggac gggacgtccg gggacgaggc
     3181 catgtctgct cccatgggca tgaatcaatg cgggttgggc ttcagtggcg cggtgtcctg
     3241 gcgcggacag cggatgccgc gcacgtctcc tcgcaactcc cggcgggcgc aagggctttc
     3301 tcgttacgcg gcagtagcct tcgaggaagt taccgccggt tactttcagg ggtcaaggga
     3361 gatgtgaaaa aagggtgtcg gatgtgcgcg gagcggtgac tgcctgcaac aactgccttg
     3421 agaacgcttg acgttgacgg ttgagcgggt ctacaacttc ccctgtttcc acggatccgt
     3481 ggcgccggat ccagcaagcg gcatccagcg cgtcccgggc gtggcacccc ccgcgcctcg
     3541 cgggcaccgg ccgcgttccc ggcccgttca cggcaaccgc tccacctcgc agcgcggcac
     3601 cggcacggtc gttccccttt ctcctcccgt gcccggccgc cccctggtcc ggcccggccg
     3661 gaggtcttcc cccgaggcct tcggccggcg cccggtgtgc cgccgtcgcg gatccgccgc
     3721 gtacggagaa ggcgctacgg ccctgcgccg gcggcatccc cgcaccaccc gccacccccc
     3781 actctcacct cagttgtccc cccacatcga caagagaggc acccgcatgc gtacgcgctc
     3841 cctcctcgtc ctggccggca ccgccacggc gctcgccctc acctgggcca cccccgcctc
     3901 cgccgccggc acggtgctca ccaccggcag caccggtggc gcggcggtcg ccgtcggcga
     3961 caccctcacc gctcccctgg cctccggcac ctccgccacc ttctactcca gcgcgaccgg
     4021 caccagcggt gtgaagtgca ccggctccca gttcaccgcc aaggtcaccg ccaacccggc
     4081 cgcgcccggc acggccaccg agtccgtcac cgcgcacacc ttcgacagca gcacctgcac
     4141 cagcaacgtc accggtgtcc tcggcgtcaa cggcatcacc atcaacaacc tgccgtactc
     4201 ggcgacggtc acctcggacg gcaccctcac cgtctcgccc ccgagcggct ccgtcatcca
     4261 ggccacggtg cagctgcgca ccctgctggg caccgtcacc tgcgtctacc aggcgcccaa
     4321 gctgaccggc aaggccgaca acgccgacag cagcatcaac ttcaccaacc agcagttcgc
     4381 gaagacctcc ggttcgtcgc tgtgcttcgc caacggctac ttcacggcca agtacgcacc
     4441 cgtcaccgac gcgggcgtcc gcgtctacgt caactgaccg accggaccgt ccggttcagc
     4501 gtcgtggcag acgccgtagc cggaacagga gggcggcgcc cccggtgagc agcagcaccg
     4561 cggtggcgcc gcccgccagc agcggcgccg agggtcccga gccgtgcgtg gcctccgtca
     4621 ccggagccgc gtcggcggcg gtgcccccgg cccgttcgcc gctctcgccc gcggcccgct
     4681 gcgcacgctc cgccggggaa gccggcggag ttggcgaagt cggcgaggat tgcgaagccg
     4741 gtgcggacgg tgcgaccggt gcggacgggg atgcctccgg ccgcgccgcc cccgccgccc
     4801 cggcggcctt cccgcgctcc gggaacacca cgtcggaaca cgcgtagtac gtgtccggcg
     4861 tactgctgtt ctgccagacc gtgtacagca cctgacgccc cgtccggtcc gtcggcagcg
     4921 tggcgctcac gcggtacgcc ccgtcgcgca gcggtgggtc cgtgacctcg gcgaagggct
     4981 gctcgggcag atcggaccag gtcagcggct tcgacgggtc gtacccctgc tcggtcagat
     5041 acagccggaa cgtgcccgtg tgcgcgatgg tcgacgcgta ggtcagcgtc agccggcccc
     5101 ccggtgccag ccgtgtcgcc ggccagtccc gccgggccag gtccagaccc cggtacgccg
     5161 gcaggttccc gctgcacagc ctgccgtccg gaatcacctt ccggtcccgg ccccccaccc
     5221 ccgccacccg caggttgtcc caggcggtga acggagcgcc gttcgccgcg atcgcggccc
     5281 ggcaggccgc cgagcgggcg gcgccgccct ccggcgaaca ggcgtagacc cggctgaccg
     5341 ggtccgtggg ggccccgtgc gcctgggccg gtcccgccgc ccacggcagc agcaggagcg
     5401 gtgccgccac ggcggccacc ctgacgcccg ggcgggcggt cgtccgagtc atccgagtca
     5461 tcggggacgt ctcctcggca ggcgcgggaa cggaatcagc ggtatccagt acgagaccgg
     5521 cgcccaccgt gttcagccgg gcgtgcgcgc ccgcgcgcgg ggggcgtgaa agcaccgacc
     5581 ggttcggctg ttttgcgcct gctcccagat ctcgttgagg agccggccgt ccgcctcgta
     5641 tcgtggcgat catgggggcg cgacccgccg ccacgaggcc gcccggcacc ggccggcacc
     5701 gaagggggaa ccgctgtggg ctcacccgtt cacgcggcac cgagcgtcct tcggtgccga
     5761 gcatgacagt gacacgtgtc gtaccacgcg cgcggtacac cggactcccg ttgcccctgg
     5821 gtgagttatc gtatgcaagg ggttaaaaac aaaccgcatg tcctgttcgt tgaggtccga
     5881 ggaggggtcc caggatggcg aggcagttac gcgctgagca gacccgggca acgatcatca
     5941 cggccgccgc cgacctgttc gaccggcacg gctacgaatc caccagtctg agcgacatcg
     6001 tcgcacacgc gaaggtcacc aagggcgccc tgtacttcca cttcgccgcc aaggaggatc
     6061 tggcccacgc catcctggaa ctccaggcga aggccgcgca acaggtcgtc gccgacgccg
     6121 agagccgtgg ctgctcctcg ctggaggccc tgatgcgcgc cacgttcggc atcgcccggc
     6181 tcgccgtcga ggaccccgtg ccgcgcgccg gactccgcct cgccaccacg gacatcgccg
     6241 tacggccgcc gctgcggcac ccgttcaccg agtggctgga cttcgccacc cgcaagttca
     6301 ccggggccgt ccgggaagcc gacgtgcacg gcgacctcga caccggcgcc gtcgcccact
     6361 ccctcgtctg cttcttcatc ggcacccggg tcgcgggccg ctcgctggaa cccgtcgggc
     6421 ggctgccgcg aagagtcgcc gagatgtggc acctcatgat ccgcggcctc gtgccggtcc
     6481 accgccgccc ccgctatgtc accctcgcca cgcagctgga gcgggagatc cgcgccgcct
     6541 gacacccgcg ctacggtgac ggacatgccc gacaccccct tcgcacccgt gatcctcggc
     6601 aacgaacccg gatcgttccc gcacagcgtg ctggccgagc ggcaccccgc gatcatccga
     6661 caggtacggg aggccttccc gtacggcccc gggcagcaca cggccctgga cgagctgctg
     6721 aagagctgca cccaggggac ggtcgagccg ctccccggcg acgccccgga ccgggaccgg
     6781 tggcacggct ggggcctgac cgagtacacc ggccggtcct ggtacgacgt gccgtggctg
     6841 tggtccgaga gctacttcta ccgccggctg ctcgacgccg tcggctggtt cggcccgggt
     6901 gcctggcagg gcatcgatcc cttccggccc ttcaaacgcg ccgaactcga cgccccggag
     6961 accgacgagg aactcgccgc cctggacggc ctgcgcgacc tccccgagga ggagcgggcc
     7021 cgcgccctgc tgcacggctc gctgtggggc aaccgcgccg acctcggctt ccggttctcc
     7081 gccgccggcg ccgaggcccg agagccggcc cccgcactgg tcgccgacga cagcgagacc
     7141 ctgtggtcgc tgctgccgcc cggcgggacg ggcacgctcg tgctcgtcgc ggacaacgcg
     7201 ggccgcgaac tcgtccccga cctcctgctc gtcgcccacc tcctcgccga gggccgggcc
     7261 gctcgggcgg tgctgcacgt caagccgtac ccgtactacg tctccgacgc caccaccgcc
     7321 gacgtggtcg acgccctgca ccggctgcgc gcggcccccg gccaggccgc cgagtacgcg
     7381 cgcgtgctct ggtcggccct ggccgacggc cggctcaccg tccgcgccca ccccttctcc
     7441 tgcgccccgc tgccgtacgc cgcgatgccg gacgacctgc gcgccgagtt cgcggcggcc
     7501 accctgacca tcgtcaaggg cgacctcaac taccgccgcc tggtgggcga ccggctctgg
     7561 ccgcccacca cgccgttccg ggagacgacc gcctccttcc ccggcccggt cgccgccctg
     7621 cgcaccctca agtccgacgt gatcacaggg ctcacggccg ccaccgaggc ggcgctggtg
     7681 gcggccgagg gccaggactg gcggacgagc ggcacacacg cgctgatcca ggtcgatccg
     7741 tcaggcgagg tgcagcggca gtgacttgat gccgttgatg aagttcgaca ccagccgcac
     7801 ggccggcccg gcgaggcgcg gcggcccggg cagggcacgc agcacctcct cgtgcagcag
     7861 ccgcagttgc agccgggcga agtgggcacc cagacacacg tgcgggccgt ccccgaagga
     7921 gacgtgcggg ttgggggagc gggccaggtc gagccggtcc ggatcggcga agacgcgctc
     7981 gtcccggttg gccgaggcgt ggaacaccac gaccttctcg cccgcccgga tcgagcggcc
     8041 cgccagctcg gtgtcccgca cggccgtccg gcggaaggtc agcaccggcg gatgccagcg
     8101 cagcagctcg tcgacggcgg acggtacgcc gaccgctccg gcgcgcagca gcccgtacgc
     8161 ctccggatgc tccgccaggg ccagcagacc gcccggggcc gcactgcgca ccgtgtcgtt
     8221 gccggccacg gtcagcagga agaagaacat ctccagttcg gcgtcggcca gctcggcgtc
     8281 gtgcgcgagt gccgtcatga tgtcgtcgac ggggtgccgg cgcttgtacg cggccagatg
     8341 tccggcgtag gcgaacatgt cccgcagcat cgcgggcgac cgcgggttca ccggcctgcc
     8401 cgccccgtcc agcaccggcg gaccggcctc gtccgggtcc tggtagccga tcacccgctg
     8461 cgtccagtgc agcagcagcc cccggtcgct cgccggcacg cccagcagat ccgccagatt
     8521 cagcagggcg tactcgtcgg tgacggcggc caccagatcg accgtgccgt ccccctcccg
     8581 tgccgccgcc agggcgcgga ccagcagcgt gcgcgcccgc tcccgggcga ccgccgcgaa
     8641 ccggtccacg cgccccggcg tgaaggcgcg gctcaccagc cgccgcagcc tcccgtgcgc
     8701 cggggggtcc tgattgagca tcatgcgccg gatgaacggc agatcctccg ggtcggggtc
     8761 acggatctgg gtcgcgccgg cgtacgagga gaacgtcccc gcgtccttca gcacgcgtac
     8821 gacgtccgcg tgccgggtca ccgcccagaa gcccggcccg gccggccagc ccagcacctc
     8881 cggctcctcc tgccaggcca ccggatgacg gtcgcgcagc acccggtagt cgtcgtaggg
     8941 caccgcggtg gcgtaccggc ggggatcgaa gacgtccggg accggtggtg cctccggtac
     9001 gctcacgccg gcccgcccgc cccggcctcg cccgacgcgc ggggcccgga tgcctcggcc
     9061 gcttcgtccg ccccctccgt ctcgtcggcc cgcaggaagt cctcgacggt acggatcagt
     9121 tccagtgggg tctcgtccat cgcgtaatga ccggcgccgg gcagaacggc gagccgcgcg
     9181 cgggggtacc aggacatcca ggtctgccgc atgacctccg gcgacagcgc cgggtcgagt
     9241 gcgccggcca ccgcgagcgc cggcacctcg ctgcccgcga cgtcggcgct gaagtcctcg
     9301 cccgcccacg agtccagcca ggcccggaac gccttggtgt cgctgcgctc cagcgagcgg
     9361 gcgaccatcc ggtccagcca ggcggcgggc cggcggcctc cggtggtgac gtcgatgatc
     9421 gtgcgccggt gctccgcccg gtgcgccgcc tgcgtgaaca gcgccgcctg ctcaccggcc
     9481 agcggcatgc ccgaggcggg cacgggcgag accccggcga tccggcgcac ccgatgaggg
     9541 gccacggcga gcagccgttg ggccaccgca ccgcccatgg agtgcccgat caccgagaac
     9601 cgctcccagc cgagccggtc cgccagctcc accaggtcca gggccgcctc ggccgtcgtg
     9661 tacgcgcccg cggcgtcccg ggcctcgccg tagccgcgca gatcgaccag cgcgtagctg
     9721 aacgacgtgc ggtcgaggtc cggcaggacg gccgcgtagg cggaccggtc ggcgaaccag
     9781 ccgtgcacgg cgaacacctt gtgggcgccg tcgccgtgca cctcatgggg cagcacgaag
     9841 gaggtcatgc gcctaccgtg gcccccgcgc gcgggcccgg caagagcgcc aacgccacaa
     9901 ccccccgccg gagttccacg tttcgcgggc ggttcacgcg atggtgtgat catgtgctgc
     9961 cgtgcggatg gggttccggg ggcacgggta gggcccggcc atgacgcagc cgttcgaact
    10021 cccgcacttc tacatgccgt atcccgcgcg gctcaacccg catctggacg aggcccgggc
    10081 ccattcgacc cagtgggcac gagagatggg catgctggag ggctcaggga tctgggagca
    10141 ggccgacctg gaggcgcacg actacggcct cctgtgcgcc tacacccatc ccgactgcga
    10201 cggacccgct ctctcgctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctcgac atgtacaagc ggacccagga ccgcgccgcg ggcaaggcgc acctggaccg
    10321 cctgccgctg ttcatgccgc tcgacctcgc cacccccgtg ccggaaccgg agaatccggt
    10381 ggaggccggg ctgaaggacc tgtgggcgcg gacggtgccg tcgatgtccg tggactggcg
    10441 ccgccgcttc tcggtcgcca ccgagcacct gctcaacgag tcgatgtggg agctgtccaa
    10501 catcaacgag gggcggatcg ccaaccccgt cgagtacatc gagatgcggc gcaaggtcgg
    10561 cggcgccccc tggtcgtccg gactcgtgga gtacgcgacc gccgaggtgc ccgccgcggt
    10621 cgccggcacc cggccgctgc gcgtcctcat ggagacgttc tccgacgccg tccacctgcg
    10681 caacgacctg ttctcctacc aacgcgaggt cgaggacgag ggcgagaaca gcaacggcgt
    10741 gctcgtgctg gagaagttct tcggctgcac cacgcaggag gccgccgaca ccgtcaacga
    10801 cgtcctcacc tcgcggctgc accagttcga gcacaccgcg ctgaccgagg ttcccgccgt
    10861 cgccctggag aagggcctca cacccggcga ggtcgccgcc gtcgccgcct acaccaaggg
    10921 gcttcaggac tggcagtccg gcggccacga atggcacatg cgctccagcc ggtacatgaa
    10981 caagggcgcg cggtccgact cgccctggca gctgaagagc ggacccggca cctccgccgc
    11041 tcacatcggc gcactgctcg cctcggccgc ccaggaacgc ctgcgcgcct actcccacgt
    11101 gccctaccag aaggtcggcc cgtcccgcat ccccgacctg tacatgccct tcgaactcca
    11161 gctcagcccc cacctggacc cggcccgcgg caacctcgtg gactggtgcc accggatggg
    11221 catcctccag gagggggtct gggacgagga caagctcgcc gcgtacgacc tcgcgctgtg
    11281 ctccgcaggc ctggacccgg acgccacccc cgaggccctc gacctcagcg cgcagtggct
    11341 cgcctggggg acgtacggcg acgactacta cccgctcgtc tacggccacc gcagggacct
    11401 ggccgccgcc cgcctgacca cggcccggct gtcgcagtgc atgcccgtcg agggcgaacc
    11461 caccgtcgtc cccggcaacg ccatggaacg cgggctgatc gacctctggg cgcgcaccac
    11521 ggccgagatg accgccgacc agcggcgcac cctcaaggcg gccgtggaca cgatgaccga
    11581 gagctgggtg tgggagctgt ccaaccagct ccagaaccgc atccccgacc cggtcgacta
    11641 cctggagatg cgccgcgcca ccttcggctc cgacctcacc ctgggcctgt gccgcatggg
    11701 tcacggcccc gcggtcccgc cggaggtgta ccgcagcggc ccggtgcgct cgctggagaa
    11761 cgccgccgtc gactacgcgt gcctcctcaa cgacgtcttc tcgtaccaga aggagatcga
    11821 gtacgagggc gagatccaca acgccgtcct ggtcgtgcag aacttcttcg gcgtggacta
    11881 cccggccgcg ctcgccgtcg tccacgatct gatgacccag cgcatgcagc agttcgagca
    11941 cgtcgtcgcc cacgaactcc ccgtcctcta cgacgatttc caactgtcgg aggaggcgcg
    12001 ggcggccatg gggggctacg tgctcgacct gcagaactgg ctggccggca tcctcaactg
    12061 gcaccggagc gtggaccgtt acaaggccga gtggctcggt cgccgtgccc acggcttcct
    12121 gcccgaccgc gcccccgccg tgcccgccct gacgttcggc tgacggtcgg ccgacggccg
    12181 taggccgggc cggcgggcgg ttcggcgcgg gtgaggcggc gggggcgggc cgggtcagac
    12241 cggctgggcg gcccgggacg ccgcatgctc gaccgcggcg cgcgccaggg cccggaccat
    12301 cgggtgcggc tgcgagccgt cgcccgccag ctccggctgg aacagcgagg ccaggaagaa
    12361 cgggtggccg ggcagctcgg ccacccggac acggccgtcc tcgtcacggc cggagaaccg
    12421 cagcccgtgg gcgcggagcg tgtcgaggtg gcgtgagggg ccgtaggcgc agaagtaccg
    12481 ctccaccgtg cgcgccgagc cgatcacgga cgcggccagc gagccgggct cgatcgtcac
    12541 cgcggcctcg tggcccacca gcgagcaggc cagcgcctcg atgagcgggt ccgtcgcgtc
    12601 cgggtcgttc tcggcgtgcg cggcgcgggt cagcccgcac acgttccgcg cgtactccag
    12661 cagcgtgtgc tggaagccgc cgcacgtacc caggaacggg atgccctcct cgcgcgccgt
    12721 gcgcaccgcc gcgaggacgc ccgcctcgct gcggtacggg ctgcccggaa gcacccacac
    12781 ggcgtcgaac ccgcgcaccg cgccctcggc ctcggcgtcc tgcgaggaga tccagtacgc
    12841 gtccaggacc agccggtcgc gggcggccag cgcctccagc agcagcggga cgcgggtgtg
    12901 ggagacaacg tgcggggagc ggtcgccgac gagggcgagg gtggcggtgt tcgtcatgcc
    12961 caccatcctc ggtacgcggt gtcattcacg tccaacgatg gtttctgtac gctcgataag
    13021 cgttgctgat ggggtgggat gctgggcggc atggacccgc acctgctccg cacctacgtc
    13081 accgtggcgc gtctcgcctc cttctcggag gccgcgcgcg agctgggcta cacccagtcc
    13141 gcggtctccc agcacatcgc cgccctcgaa caggacctgg gcgggccgct gctgacgcgc
    13201 cggccggtcg cgcccaccgc ggcgggcgag cggctgctgg agcacgcggg tccgctgctg
    13261 ctgcggctcg acgcggcccg cgccgacatc ctccgcatgg ccgccgcccc ccagcacggc
    13321 ctgaccctcg tcaccaccgc gaccgcgctc ggccccgccg tcctcggcgc gctcccgccg
    13381 gccggcgtca ccctgcgcgt cctcacccga gcggagatcc ccgccgccgt cgccaccggc
    13441 accgccgacc tcggcctcgt cgacgggctg gccgcgccga gcgatccgct gcggctgccc
    13501 gacgtggcac cgctgaccgc gcgcggcgtc gcggaggagc ccgtgagcgt cctgctgccc
    13561 gccggacacc ccctcgccgg ccgccccggc ctgcgcctcg gcgacctccg cgacgcccgc
    13621 tggctcgacg cgcccgacgc ggggctcccg ctcgcgcagc tgcgtgccgc gaccgcgggc
    13681 ggcggcgcct tccggcccgc cctgcgctac gagggcaccg acgtgcgcac cctcaccacg
    13741 ctcacggcgg ccggccacgg actgaccctg ctgccccgct cggcggccac ggccgtcccc
    13801 ggtacggccg ccgtccccct caccgccccc cgcctcgtcc accgcaccga actcctgcac
    13861 ggcggcagcc ccggcggagc ggcggcggag gtggtgcgcc ggctggcgaa cgggcggtga
    13921 gccgcggcgg ggagggggcg gcctcgacgg gttggggttg agtggggcgg tgggggccgg
    13981 cgtacgcccg gtggcgagat gtcgcggccg acggcgaccg ctggaggcgg cgcggcgggc
    14041 gggatgctcg ggtccggcag tggggccggc gccgaggtcc ggcggcctcg gctgccgtag
    14101 ccgccgtggg acctcgcgtg ccgcttcgac ggccatgact accctccgcc acccttcggc
    14161 cattctcact cgttcgtgtc tcgtcgcggc ccgccgcccc gggtagagca ccagccggag
    14221 gcgagcgaac catggaacag actgcgttgc gtcccaagcc gatgcccgga caggagcggc
    14281 gggacgacgg caccgccggc ccggcccacc ggccgcacgc cgcgccccgg cgcggacggc
    14341 ggttgcgggc cgtgctgccg gccctgtgcg ccggcatcgt gctgctgttc gccggcgtcg
    14401 ggatcggcac ggtcggtgcc acggtgatcg gcatgagccg actcgccgag ctgcagcgcc
    14461 aggccccgcc gcccgcccgc ccggccgagg ccggccccac gaccgcaccg gcccccgccc
    14521 ccgctccgcc ccgcgcgacc ctgggcctgg aggccgtcga cgccgagaag gcgggcgcga
    14581 aggtggtggg cgtgcacgtg cccggccccg gctacgcggc gggcctggtc cgcggggacg
    14641 tcgtgctgca cttcggcgcg gcccgcgtcg acaccgcagc cgacctcgcc cgagccgtcg
    14701 cgcgggcccg cccgggaaag gcggtgctcc tcaccgtgcg ccacagcagc gggggctacc
    14761 agcagttggc ggtgatcccc ggcgtggtga cctgaccgaa ccggcaccgg cgcgggagcc
    14821 tacggcaagg cacgtccgga agccacggac acgcccgcgg ccccgccgcc gctctccgac
    14881 ggcgtccggc gtcgccctcc ggccgtgtcc ggtgtcgctc ttcggccgtg ttcggtgtcg
    14941 ctcttcggcg gcgttcggtg tcgctcttcg gccgtgttcg gtgtcgctct tcggcggcgt
    15001 ccggtgtcgc tctccggccg tgtccggtgt cgctctccgg ccgtgtccgg cgtcgctctt
    15061 cggcggcgtt ccccgccgcc ctccggccgc gttcggcgtg gccctttggc cgtgttcggc
    15121 gtcgctctcc ggccgtgtcc ggtgtcgctc tccggccgtg tccggcgtcg ctcttcggcg
    15181 gcgttccccg ccgccctccg gccgtgttcg gcgtggccct ttggccgtgt tcggcgtcgc
    15241 ccttcggccg tgtccgccgc cgcgagcgcc ccgttccggg gcccgtgatt ctccagcccc
    15301 cgccccgccg caccaccccg agcccggtga tctcgtacac cccacgaaac ccgctggtca
    15361 ccgtccgtcc cggcgcgtca tcatggcccc atgccgagcc ccttcgcgac gacccccggg
    15421 acacagggcc ccgggaccgg ctcgcgtgcc gctgtccggg cgggcaggat gctgcccgag
    15481 acgccgcacc ccgtcgcctc acccgctgcc acgcccgttt cctcacccgc gctcggaggc
    15541 ccggatgacc ggtagtacgc ccgcgccctt caccgccgcc gactacaggg cccgcatgga
    15601 gcgcgccgcg cgctccgccg cggacgccgg cctcgccggg ctgctcgtgg ccccgggacc
    15661 ggacatggtg tggctcaccg gctacacgcc caccgcggtc acggaacggc tcaccgtgct
    15721 ggtcctcgcc cccggccgcg accccgtcct cgtcgtgccc accctggagg ccccggacgc
    15781 cgagcaggcg gccggcgcca ccgcgctgac cctgcgcgac tggaccgacg gcaaggaccc
    15841 ctacgccgtc accgccgacc tcctcgacga ccgcggccgg ttcggcatca gcgacaacac
    15901 ctgggcgatg cacctgctgg gcttccagcg gaccctcccc gacacctcct acgcctccct
    15961 caccgacgcc ctgcccatgc tgcgcgcggt gaaggacgcg gccgagctgg aactcctggc
    16021 agccgccgga gcggctgccg acgcaacgtt cgaggagatc cggaaggttc ccttcgccgg
    16081 ccgtcgcgag tccgacgtcg gccacgacct cgccggtctg ctgcgccgct tcggccactc
    16141 ccaggtcgac ttcaccatcg tcggctccgg cccgaacggc gccaacccgc accacgaggt
    16201 cggcgaccgg gtcatccagc ccggcgacat ggtcgtcctc gacttcggcg ggctgatgaa
    16261 cggctacggc tccgacacca cccgcacggt ccacgtcggc gagccgaccg aggaggagcg
    16321 ccgggtccac gacgtcgtgc gcgccgccca ggaggccggc gtccaggccg tacgcccggg
    16381 cgtggcctgc caggaggtcg accgcgcggc ccgcgcggtg atcacggacg ccgggtacgg
    16441 cgagtacttc atccaccgca ccgggcacgg catcggcgtc acgacgcacg agccgccgta
    16501 catgatcgag ggcgaggagc agccgctcgt gcccggcatg tgcttctccg tggagcccgg
    16561 catctacctg cccggccgct tcggggtgcg tatcgaggac atcgtcacgg ccaccgagga
    16621 cggtggccgc cgcctcaaca acaccacccg tgagatggtc atagtggact gagaggccca
    16681 aggagacccc ttctcgacga cacccggaac ggctacccgc gacccatgac ccaggctccg
    16741 acacccaccg cggacaccgt ccgcagactg gtccgttcgc tgctcaagga gggcggcgac
    16801 gacaccgggg gacccgatgt gcggcccgtg acggaggacc gcgagcacac ctggtggatc
    16861 ggcagccgcc atgtgctgcg gctcgcgccc gaccgcgagg cctctctccg ccgtcgccgg
    16921 gaactgcgcc tgcgcgacct ggtccgcccg cacgtacccg tcgccgtgcc gaccagcgtc
    16981 gcgcacggcg actgggcgcc cggcctggcc tacaccctcg acacccgggt gcccggcggc
    17041 acggccgacg agtacgacgt ctccgcggtc ggcgaggccg acctcgccgg gctgctcagc
    17101 gggctgcgta cggtgctcgc acgccaggcg gaggcgctcg gcgtgccgcg cgtcgcgccg
    17161 cgctccctgg acgcgctgcg ccggatggcc gtgcacgcgg ccgaacggct cgccgcggcc
    17221 gacgagttcg acgccgcccg gctgcaccag ctcacccagc ccggcgcggc tcagctcgcc
    17281 acgcagcccg gtgccgccgt cctcacccat cacgggctga ccggcgcgca cgtggtggtc
    17341 agcgccgacg gccgggtgcg cggcatcctg gactggaccg cggcggccct cggcgacccc
    17401 gccgaggaca tcgccgggct cgccgtcgcc gtcggctcgc ccgcggcggt ccgcgccgcc
    17461 accctcgccg gctacggcgc ccgcccctgc ctgcgcggcc tgtggctggc ccgctgtgac
    17521 gccgtcatcc gcctcaccga ccatctggag ggccgtacgg gcggctccct gaccctgctg
    17581 cggacccagc tgcggcgcgc ctgggagccg atcctgctgg agcgcgtgac ggacttcccg
    17641 gaggacgagc cggagccctg acgcatccgc agcccctcgc cgccgcacct ccggccgcag
    17701 cccctcggcc cccgagcgcc ggccgcaggc cctcctcaag gtccgacgcc ggtcgcacgc
    17761 tctcctcagg gcccgaacgc cggccgcggg gtcccctcag ggcacccgag gcagccgcgg
    17821 ggcgcggacg gcagccatgc ccgccgttca gcgccccgtt ccctcacggc tgggtcagca
    17881 ccacgcacga ctccccgggc acctggagca gtccgtccgg gcccggtgcc tggaccggtt
    17941 cccaggccgc gaggacctcc atccggccgg tgccgagcgg aatcgcggcc tcctccttgc
    18001 ccaggttcac cgccacccgt acgtccccgc gccggaaggc cagccagcgg gcgtccgcgt
    18061 cgtacgccac cttcgtgtcg gcgaggtccg ggtcggtgag atcgggctgt tcctgccgca
    18121 gggcgatcag ccggcggtac caggccagca cgcgcgcgtg gggctcgcgt tccggctccg
    18181 accagtccag gcaggaccgt tcccgggtcg ccgggtcctg cgggtcgggt acgtcctcct
    18241 cggcccaccc gtgcgaggcg aactcgcgcc gcctgccccg ccgtaccgcc tcggccagct
    18301 cgggatcggt gtggtcggtg aagaactgcc agggcgtggt cgccgcccac tcctcgccca
    18361 tgaacagcat cggcgtgaac ggcgcggtca gcgtcagcgt ggccgcgcag gccagcagac
    18421 cgggggacag gagggcggag agccggtcgc cctgggcgcg gttgccgatc tggtcgtggg
    18481 tctggctgta accgagcaac cggtgcccgg ccacccgcgt ccggtccagc ggccggccgt
    18541 gccggcggcc ccggaagctg gagtacgtgc cgtcgtggaa atagccgccg gtgagcgtct
    18601 tggcgagcgc ggcgaaggga tcccgcgcga agtcggcgta gtagccctgc gactcgccgg
    18661 tcagcgcggt gtgcagggcg tggtggaagt cgtcgttcca ctgtgcgtgc agcccgaggc
    18721 cgtgctccgc gcgcggggtg atgaaccgcg ggttgttcag ctccgactcg gcgatcagga
    18781 acagcggcct gcccgtctcg gccgccaggt cgtccacggc cgccgacagc tcctccagga
    18841 agtggcacgc gcgcgtgtcg tacagcgtgt gcaccgcgtc cagccgcagc ccgtcgatcc
    18901 ggtagtcccg cagccacgcc agcgcgctgc cgacgaggaa ggcgcgcacc tcgtccgagc
    18961 cgggcgcgtc caggttcacc gccgagcccc acggggtggt gtgcgtgtcc gtgaagtacg
    19021 gcccgaaccg cggcaggtag ttgcccgacg ggcccaggtg gttgtgcacg acgtccagga
    19081 cgacgcccag cccgagttcg tgcgcccggt cgacgaagcg cttcagtgct gcggggccgc
    19141 cgtacggctc gtgcaccgcc cacagcgaca ccccctcgta cccccagccg tgccggcccg
    19201 ggaaggggca cagcggcatc aactccacgt gtgtcacacc cagttccacc aggtgctcaa
    19261 gacgggccgc ggcggcgtcc agggtgccct cgcgggtgta cgtgcccacg tgcagctcgt
    19321 acagcaccgc gccgggcagc gcgcgtcccg gccactgcgc gcgccacgcg tggcgcccgt
    19381 ggtccacgac cgcgctcagc ccgtccgggc cgtcgggctg gcggcgcgag cgcgggtcgg
    19441 gcaggacggg accgtcgtcc agcgcgaacc cgtaccgcgc gccgtccgcc gcctccgcct
    19501 cacccgtcca ccacccttcg cgcgcgggat cgcgcgccaa cgcgcgcgtg gtgccctcgc
    19561 aatggagcgt cactcggtct gcctgcggtg cccacacctc gaactgcacg gacggttccc
    19621 cttcgtctgc tcaccgtgat gtcccgcgtg tccatcgtgc cgccccggac gatcaatccg
    19681 ctttcgaatt cgccctttgg tggcaggtgt cgcggaagtg tccgcacacc cgcacggatt
    19741 ccggggtttc tggacacccg gggtgcactg cccgacaatc acctgcgtga cgtcgtcctt
    19801 cgagttctcc acctacccgg cgcgcctgtc cgacgaggag cgcgacaagg cgctgcgggt
    19861 gctgcgcgac ggcgtcgcga tgggccggct ctcgcacgac acgttcgtgc gccgcatgga
    19921 gctggcactc gccgcgcgcc gctccgacga actcgccgcc ctggtcgccg acctgccccg
    19981 ggagaaccgg ttctcccgcg cggtcctggg caccgtggag gccgtctccg ggttcaccgt
    20041 gcggctgcgc cgggcctggc aggccgagcg gctgcccaag ctgctgctgc cgcacccggg
    20101 actcggccac ccgctgcgca tcggccgcga cccggcgaac gggctgcgcc tcaaccacga
    20161 gaccgtctcc cgggtgcacg ccgaactccg ccaccagggc ggcctgtggg tgctcaagga
    20221 cctgggctcc accaacggca ccaccgtcaa cggccgccgg gtggtcgggg cggtcgccgt
    20281 ccgcgagggc gaccaggtgg ccttcggcag gatggcgttc cggctcacgg ctccctgagc
    20341 ctgcccggcc ggtcccgttc gaacgcgtgc tcccgcacgc gcgcgtgccg tcccgatcgg
    20401 gtgagccgca ctgcggaagc cgggccgccg tgccgatgga acgggcatga cgtacctcac
    20461 cagaacggca gcggcggccg gcgccctgct ggccgccgcc ggtctcctca ccgcgggccc
    20521 ggcccgtgcg gcctcccacg acctcgttcc cgccaactgg ctccatctga cggtcaccaa
    20581 gggcgacgcc cgctccggtg acacccgcgg cgcgctgctg ctgtgcgacc cgccgcgggg
    20641 gcacgcgcgc gcgagcgagg cgtgcgccga actggccgcc gtcggcgggg acatcggccg
    20701 cctcccggcc gccgacacct tctgcccgat gatcttcgcc ccggtgaccg cccacgcgcg
    20761 cgggcgctgg gacggccgga cggtcgactt ccgggagacg tacacgagcg cgtgcgtcat
    20821 gagggcacgg acgggatccg tcttcaccct ggacggctga ccggagccgc ccgggcgggc
    20881 ctgcacgggc cggcgtcccc ggggctcggt gtgcgggctg gtgcgccggg gcagaggcac
    20941 gccggctggt gtcccggggc tcggcggcgt gggccggtgt ctcgggccgg gtggcgtggg
    21001 ccggtgtccc gggccgggtg gcgtgggccg gtggcgcagg ggagggtggc gtgggccggg
    21061 gcggctcacg ccatctgctc acgcgcctgc tgcgccgcca ccagcacggt ccgggactgg
    21121 tgctccacct ggtgctccaa cggcacccag cgggcccgga accgctccgc gaaggcgtcg
    21181 caccaggtgg cgacgagctg ctccaggcgc ggtgccgccc ggtcgtccgt ctcccgcagc
    21241 acccgcagca gcatcgacgc ggcccgcagc ggcagccggc gcccgaaggc gtccacgctg
    21301 ccgacgtacg ccatcgtcgt gcccgcaggg gcggtgtgga tccagtcctc ggccaggccc
    21361 gggatcagcc cgagcgccca ccgcgcggcc cgcagcagcg gcccgtccac gccctccagc
    21421 cggggcagcg cctcggcgag gatccgctcc acctcgcgcg cgtcccgcag cagccgcgcg
    21481 gccagccgcc gcatggccgc cgccggagcc gggtgcggtg ccgggtcgtc caccaggtcg
    21541 ctcgcccaca tcggcacctc caccacggcc gtcaggccgc cgtaccggtg cgcgtggtac
    21601 caggtgctgt gccgggcgtc gtccggcatg ctcgggtagg ccacgccggt ctccgggccg
    21661 ggcatcacgt gcactccggg gcccgaggcc ggccagcccg ccgcgtccga ggcccccgtc
    21721 tccaccggaa tgtgcagttc cgccgcggac ttggcgaacg gctcggcgag gcccgggacg
    21781 tccctggtca gctgcaccca gctgccgccc aggtcggtgc cgtgcagcgt cacctggaga
    21841 tagggccgca actcgtcgat caccccggtc agcgcccgcg tctcgggcgg cagccggtcc
    21901 ggcggcagca ccgccggcga ccactccggt tgctccgcgc cggtcggccg gtagaagccg
    21961 aggtggtagt cgagcaggct gcgcggcgcc ggggtcacat gcagactcgc cccgtccggg
    22021 tccgcgcaca gcaggaagtg ccaggaggtg tccgcccgca actcgcgctc cgccagcact
    22081 ctttcggcaa gcacccgcag cgtggaaccg cccgtcggtt cgttggcgtg cgcacccgcc
    22141 accacgagca cggcacggcg ggc
//
