LOCUS       NZ_AP024135            21131 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5140685
            Orig. end                         :: 5161816
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="17"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21131
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11131](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11131
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(436..693)
                     /locus_tag="K6K39_RS23045"
                     /old_locus_tag="EASAB2608_04724"
     CDS             complement(436..693)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563321.1"
                     /locus_tag="K6K39_RS23045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04724"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_003992873.1"
                     /transl_table=11
                     /translation="MDWRHNAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVIEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA"
     misc_feature    738..753
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(739..750)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    918..927
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            complement(1017..1985)
                     /locus_tag="K6K39_RS23050"
                     /old_locus_tag="EASAB2608_04725"
     CDS             complement(1017..1985)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134762.1"
                     /locus_tag="K6K39_RS23050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04725"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_094373187.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARRRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAAESDDIDLVVALGGDGTVNEVVNGLLHAGPAPDRLPGLAVVPGGSTNVFARALG
                     LPNDPVEATGALLDALRQGSERIVGLGLTSGTPGTEDEAVPARWFTFNAGLGFDAGVVG
                     RVEQQRERGKKSTHALYVRQVIRQFLGEPNRRHGTITLEQPGADPVEDLVVAIVSNTSP
                     WTYLGNRPMYTSPKASFDTGIDVLGLSRLSTAAVARYGTQLLTSSPERGPHGKHAVSLH
                     DLDQFTLHSKVPLPLQMDGDHLGLRTSVTFTGVRRALRVIV"
     gene            2122..2574
                     /locus_tag="K6K39_RS23055"
                     /old_locus_tag="EASAB2608_04726"
     CDS             2122..2574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674913.1"
                     /locus_tag="K6K39_RS23055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04726"
                     /product="hypothetical protein"
                     /protein_id="WP_059252541.1"
                     /transl_table=11
                     /translation="MSSQQKSAPDTAASAAAAEPRPRRLTYAAALAALEGAALAAGGLW
                     VLVRGLTGAPDDRQQAVTLGITLLVLALLPLLAARGLLLRRSWSRGPAVITQVMALPVA
                     YNLLQADSMAIPAGIALAVVAVAALVLLVNGETTRALGIKGPGRAE"
     gene            complement(2624..3736)
                     /locus_tag="K6K39_RS23060"
                     /old_locus_tag="EASAB2608_04727"
     CDS             complement(2624..3736)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136656.1"
                     /locus_tag="K6K39_RS23060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04727"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_223283798.1"
                     /transl_table=11
                     /translation="MRDEERGTRELPTGDGGAPWSTSAETSGADPRDGSRRTADGIDGI
                     PEQARPHPEDDSARASGDDAGQGTPPEAADGAGTAVRAGARARGRATGGTMSEHERHAE
                     DDTPATEAVQAVRHDAQDRSGARAMFIELRALPEGSAEYAELRNQLVRMHLPLVEHLAR
                     RFRNRGEPLDDLTQVATIGLIKSVDRFDPERGVEFSTYATPTVVGEIKRHFRDKGWAVR
                     VPRRLQELRLSLTTATAELSQLHGRSPTVHELAEKLAISEEEVLEGLESANAYSTLSLD
                     VPDTDDESPAVADTLGAEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQI
                     AQEVGISQMHVSRLLARTLAQLREKLLVEE"
     gene            complement(3754..4170)
                     /locus_tag="K6K39_RS23065"
                     /old_locus_tag="EASAB2608_04728"
     CDS             complement(3754..4170)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="K6K39_RS23065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04728"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_009190566.1"
                     /transl_table=11
                     /translation="MSQIAGEPAANQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLD
                     EIEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWT
                     VLSALAGKVSSAVDEDKTVSISLYKQRGAGPGPA"
     misc_feature    4298..4311
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    4426..4436
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(4491..4751)
                     /locus_tag="K6K39_RS23070"
                     /old_locus_tag="EASAB2608_04729"
     CDS             complement(4491..4751)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="K6K39_RS23070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04729"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_059252542.1"
                     /transl_table=11
                     /translation="MKQCTHADALPHPEPEPLDQTCPECLRDGTHPVQLRLCLTCGHVG
                     CCDSSPGRHATEHHEKSGHPVMRTFEPGEDWRWCFVDHVLV"
     gene            4813..6396
                     /locus_tag="K6K39_RS23075"
                     /old_locus_tag="EASAB2608_04730"
     CDS             4813..6396
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674917.1"
                     /locus_tag="K6K39_RS23075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04730"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_059252543.1"
                     /transl_table=11
                     /translation="MDVMPLLLLVAGSAAVAAAARRTPAPAPLLLVAVGLAVSYIPGVP
                     SYTLDPHIVLPLLLPPLLYTSASDSSYLDLRAQLRPVALLSVGYVLFATVVVGWAAHLI
                     VPGLSLPAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLLNDATAITAYKVA
                     LGAAVGAGATWAGGIGEFALAAVGGVGIGLVLMAPLHWLRTHLTEPLLQNTLSLLIPFV
                     AYAVAEQAHASGVLAVVVVALYLGHRAWEVDFATRLQEHAVWKMVAFVLESAVFALIGL
                     QLPIVIERLGAYEGTSAVWYAVAVFLVVVVARFVWVYPATFLPRLLSARVREREENPTW
                     RGAMVTSWAGMRGVVSLAIAFAIPPTMPDGPRNLILFLTFTTVIGTLVVQGVTLPPLIR
                     LLKFPGRDRQAETLAEANAQAQASRAAEARLDELLSDERNALPPPLADRLRAVLERRRN
                     AVWERLGQVNPVTGESVDDTYRRLSREMISAEREVFVRLRDLRYIDDEMLRALLRRLDL
                     EEAAAFREAG"
     gene            complement(6393..7313)
                     /locus_tag="K6K39_RS23080"
                     /old_locus_tag="EASAB2608_04731"
     CDS             complement(6393..7313)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674918.1"
                     /locus_tag="K6K39_RS23080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04731"
                     /product="1-aminocyclopropane-1-carboxylate
                     deaminase/D-cysteine desulfhydrase"
                     /protein_id="WP_221334822.1"
                     /sec_met_domain="PALP (E-value: 7.2e-21, bitscore: 73.7,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPDPLAPRLPSPVHEIRDERFGRRGLRLLLKRDDLVHPELIGN
                     KWRKLVPNIAAAQGRALVTFGGAYSNHLRATAAAGRLLGLPTTGVVRGQELAGRPLNPS
                     LARCAADGMRLHFVDRSTYRRKTDPETLAGILHAAGAEGAYVVPEGGSNAEAVRGCRAL
                     GAELRGHADVVAVACGTGGTLAGLAAGLAAGQRALGVPVLKGGFLEADVQTLQERAFGA
                     RTGTWSLDDRFHCGGYARTTPELEAFARDFEQRHGLPVERLYVAKLLYGLVALAQENAF
                     ARGTTIAAVVTGRPFPDPGPAAAGR"
     gene            complement(7445..8038)
                     /locus_tag="K6K39_RS23085"
                     /old_locus_tag="EASAB2608_04732"
     CDS             complement(7445..8038)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674920.1"
                     /locus_tag="K6K39_RS23085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04732"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_059252545.1"
                     /transl_table=11
                     /translation="MAPPMSASAFLAALRAEGVTVVEVGDWQHHNRNHKGPWGPVHGVM
                     IHHSVTRGSARTVELCRDGHEDLPGPLCHGVITKDGTVHLVGYGRANHAGLGDDEVLRA
                     VIAEKGLPPDNEANTDGNRHFYGFECENLGDGEDPWPEEQLEAIERVAAALCRHHGWTE
                     RSVIGHLEWQPGKVDPRGFTMSSMRERVRERLKD"
     misc_feature    complement(8121..8135)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.54"
                     /tool="antismash"
     misc_feature    8277..8292
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.06"
                     /tool="antismash"
     gene            8470..9876
                     /locus_tag="K6K39_RS23090"
                     /old_locus_tag="EASAB2608_04733"
     CDS             8470..9876
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="K6K39_RS23090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04733"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_059252546.1"
                     /transl_table=11
                     /translation="MSVGEEVRTEQGRPQQSLGTAAARNLATTTKSVPQMQEISSRWLL
                     RTLPWVDVQGGTYRVNRRLTYAVGDGRITFVKTGDQVEVIPNELAELPALRSYEDEEVL
                     TELARRCRQRDFAPGEVIADFGNRTDEVYLLAHGRVEKVGTGPYGDDAVLGVLADGAYF
                     GDQALIDPEAIWEYTVRADTATTVLILSRQDFAQVAERSDSLRAHLERLRSIPEQRTNK
                     YGEKEVELAAGHSGEPDIPHTFVDYEARPREYELSIAQTVLRIHSRVADLYNQPMNQTE
                     QQLRLTVEALKERQEHELVNNPEFGLLSNCEYDQRIQPHDGVPSPDDLDELLSRRRGTK
                     LLLAHPRAIAAIGRELNKRGLVPETIDIAGNRIPTWRGVPIYPCNKIPISEARTTSIIA
                     MRTGEAEQGVIGLRQSGIPDEIEPSLSVRFMGINEQAIIKYLVTAYYSAAVLVPDALGV
                     LENVEIGRWR"
     gene            10001..11131
                     /locus_tag="K6K39_RS23095"
                     /old_locus_tag="EASAB2608_04734"
     CDS             10001..11131
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973720.1"
                     /locus_tag="K6K39_RS23095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04734"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_399009383.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-59, bitscore:
                     200.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETEERASGVPGPGAPGEPREKTGEGTGPADAQEAAAQLERTRA
                     LVDPELRAAVESLPGSMRRIGLYHFGWQQADGSPAAGNAGKAIRPALVLAAAAALGGPA
                     ARTATVRAAAAVELVHNFTLLHDDVMDRDTTRRHRPTAWTVFGDTDAILAGDALQALAL
                     RLLAEDPHPASVPAAARLAACVVELCEGQHTDTDLEQRAPEAVTLDEVLAMAEAKTGAL
                     LGCACALGALYAGAGEEEVAALDGFGRQAGLAFQLIDDVIGIWGDPRHTGKPAGADLAA
                     RKKSLPVVAALTSGTPAAVELAQLYGKPYREEAAEAGEIARIALAVERAGGRDWAQAEA
                     ADRMARAMQELARAVPDPEAAGGLLALAEFVTRRTS"
     gene            11519..11752
                     /locus_tag="K6K39_RS23100"
                     /old_locus_tag="EASAB2608_04735"
     CDS             11519..11752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674924.1"
                     /locus_tag="K6K39_RS23100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04735"
                     /product="hypothetical protein"
                     /protein_id="WP_107475804.1"
                     /transl_table=11
                     /translation="MDSEKHVCPVCGQAVDTVVKRHKTLGAWVPVWGPGPCHDPGCAAY
                     AGPGRPAGSGRHADADRSAESGRSAGAENSGV"
     gene            11819..12151
                     /locus_tag="K6K39_RS23105"
                     /old_locus_tag="EASAB2608_04736"
     CDS             11819..12151
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674925.1"
                     /locus_tag="K6K39_RS23105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04736"
                     /product="DUF952 domain-containing protein"
                     /protein_id="WP_059252549.1"
                     /transl_table=11
                     /translation="MPKLPYILHITERSLWEAARARGAYEMSTRGRTLQEEGFIHCSTR
                     DQLPRIADFLYGGYDGPDQLVVLVVDPARVGVPVKYESAEPGGEEFPHVYGPVPVGAVV
                     DVETWG"
     gene            complement(12165..12929)
                     /locus_tag="K6K39_RS23110"
                     /old_locus_tag="EASAB2608_04737"
     CDS             complement(12165..12929)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000782.1"
                     /locus_tag="K6K39_RS23110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04737"
                     /product="VOC family protein"
                     /protein_id="WP_059252550.1"
                     /transl_table=11
                     /translation="MTIRWTYAFADRPAARLADACAFWTAVTGTRLSAFRGDRGEFVTL
                     LPEGADPSGKLQGVTDGAGGAHIDLCTEDVRELTGRARQHGAALVADHGDWAVLRSPAG
                     LLFCAVPWHGETVRPPVVSGSRLDQVCLDIPPSRYDSESAFWAGLTGWERLPGSRPEFT
                     VLRPPAGLPHRLLLQRLDEDRPASAHLDLACADIPAVRARHEKLGAVVASEGAHWTVMR
                     DPAGGLYCLTGRDPETGGLPGVGPAQGAADAG"
     gene            complement(12982..13398)
                     /locus_tag="K6K39_RS23115"
                     /old_locus_tag="EASAB2608_04738"
     CDS             complement(12982..13398)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142334.1"
                     /locus_tag="K6K39_RS23115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04738"
                     /product="VOC family protein"
                     /protein_id="WP_059252551.1"
                     /transl_table=11
                     /translation="MDVKLAQCFLAVDDHDKAVAFYRDVLGLEVRNDVGFEGMRWVTLG
                     SPLQPDVEIVLEPPDASPDASPADKQALNELLAKGLLRGVIFTTPDCDALYERVRRSGA
                     DVLQEPMDQPYGVRDCAFRDPAGNQLRFIERPTA"
     gene            complement(13433..13834)
                     /locus_tag="K6K39_RS23120"
                     /old_locus_tag="EASAB2608_04739"
     CDS             complement(13433..13834)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674927.1"
                     /locus_tag="K6K39_RS23120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04739"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_086696943.1"
                     /transl_table=11
                     /translation="MTALEDLRRLRRVRDRMDREYAEPLDMTELARDALMSPGHFQRSF
                     RKAFGETPYSYLMTRRIERAKALLRRGDLTVTEVCLAVGCTSLGSFSSRFTELVGETPS
                     AYRARDHEESAAIPPCVARRLTRPRRRPY"
     gene            complement(14205..15323)
                     /locus_tag="K6K39_RS23125"
                     /old_locus_tag="EASAB2608_04740"
     CDS             complement(14205..15323)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492111.1"
                     /locus_tag="K6K39_RS23125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04740"
                     /product="DUF4062 domain-containing protein"
                     /protein_id="WP_221334823.1"
                     /transl_table=11
                     /translation="MRIFISSVRKGLEEERDALPGLIRAVGHTPVLFEDFSAQTTPSRQ
                     ACLAALDSADVCVFLLGPSYGHVFPETGQSATHDEWVAAKTAGKPRWVYRKLGVTFENA
                     QQDFARTVEAYATGGFRDSFHNTAELMTKVVAKIKEVESDRSPLSFAPLTQPVSLRWSL
                     DQAGVDVDTSLPLLELHVLPVGFPGYSARELDELGTSLADRIRRAGAVKSSVALTSSSS
                     REHAIVGISVARPRAFDAPQHGELVEVRLYKSGQVSLRATLPRDNMGSILDHDALPQQV
                     ASLLRFNGALDLIQSERIVVAIGVSNPKMTQIDRFNPHQSRTRADLSAYTRSFTLQTEP
                     DESMSLAALDTGAEEVAGILSRALIKQHPSSS"
     misc_feature    complement(15309..15324)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.14"
                     /tool="antismash"
     gene            15402..15854
                     /locus_tag="K6K39_RS23130"
                     /old_locus_tag="EASAB2608_04741"
     CDS             15402..15854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492112.1"
                     /locus_tag="K6K39_RS23130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04741"
                     /product="hypothetical protein"
                     /protein_id="WP_221334824.1"
                     /transl_table=11
                     /translation="MAEVSDEAIRAYWKEHREQLRQCETQRSTLSSLLLVITAALSALI
                     VQQKFSTYVMPLCLFVALTGGYGAVAVSKYFERASYHLSQARALTKDLVELGVLGSDER
                     LIRARDDHYRLFPRLHRIRLHRLWVILHLAIALYGLCLFGICVVVV"
     gene            complement(15921..16451)
                     /locus_tag="K6K39_RS23135"
                     /old_locus_tag="EASAB2608_04742"
     CDS             complement(15921..16451)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889142.1"
                     /locus_tag="K6K39_RS23135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04742"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_221334825.1"
                     /transl_table=11
                     /translation="MPNNAPDEGNTVTQQTGDQPKALKPALESMTLLVAAVIVHDKTAN
                     RVVLLQRSENAKFAQGMWDLPVGKSEPGEPITETAVRELYEETGLTVKPQSLKVAHIIH
                     GASGVEAPNGFLTVVFAAHEWTGEPENREPRKHAQVCWVDVDAIPTEFVNTTASALYRY
                     LMGGPEVSLDGWG"
     gene            complement(16453..17808)
                     /locus_tag="K6K39_RS23140"
                     /old_locus_tag="EASAB2608_04743"
     CDS             complement(16453..17808)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127273.1"
                     /locus_tag="K6K39_RS23140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04743"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_221334826.1"
                     /transl_table=11
                     /translation="MTAQRDPNSRLRDAIVAVDCTYEALARDVRRIAAENGEILQTNKS
                     AISHWVTGSRAPSGRVGQYLAEALSRRAGRTITQTEIGLQTGDNEEPAESDPVLAVTDL
                     GRADVERRRFLAIAAFTTAGVAMPLGYDHEAAARMLRARTGTSLVGAEDVDVVRQITAA
                     FSAADERLGGGHGLTTVTAYLADTAAPMLRGRFPSEALRRAAFGAVAELAYLAGWKHHD
                     LGQEGAAQRYYQVGYQLACEADPHGHAAWMMRALAHQALSLKQPHHCVDLVEGALRAGL
                     GHIDGRTEALLHITHARAYAAVNENPQAARALLAAEDALLRDDGPQPSYSLVSGPAAGT
                     VASHTARTLTDLADHIGTEQQHRDALTRWDPAKYKRVHALTHADLGDSLAAQARADEAV
                     AAWTQALVLMEGMTSDRTLKAITSIRSTLAVYQRRKVPGAADLARRAREALA"
     misc_feature    complement(17206..17208)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17869..17882)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.48"
                     /tool="antismash"
     gene            18031..18780
                     /locus_tag="K6K39_RS23145"
                     /old_locus_tag="EASAB2608_04744"
     CDS             18031..18780
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004926278.1"
                     /locus_tag="K6K39_RS23145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04744"
                     /product="hypothetical protein"
                     /protein_id="WP_221334827.1"
                     /transl_table=11
                     /translation="MTTIDTTAITVELPEAFDERWSRLPGIQVDGRRITIDPAEYFFRF
                     ESSTWLVADWELVKSQLLDVEETAESAVEQLALDFIKAHGESTSNAARVLSTAYEVYAY
                     LFRDEHLAGLGLPQITAEHLRMLREAATLMALNKVELDGHISNVGPCWFFPAATSVVFD
                     LDDEMGGMLDEVYHGGWFNEHRRIESIKAHAALGGRLVHGCQSVPDQSGGVVAPYGASM
                     ANFRDDLAAFKAGWIEQVYAHRVTPAA"
     gene            18857..19768
                     /locus_tag="K6K39_RS23150"
                     /old_locus_tag="EASAB2608_04745"
     CDS             18857..19768
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674236.1"
                     /locus_tag="K6K39_RS23150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04745"
                     /product="phosphotransferase"
                     /protein_id="WP_221334828.1"
                     /sec_met_domain="APH (E-value: 2.4e-10, bitscore: 39.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNNLTTDLLANLCTLVDQPSAKREEVRVWSMSGVERVTFPDGST
                     RIFKYAKRPFDSEDQALRLADTLGIPAPKVYSSVRIEGWLGMLLEDLGTPIREADDLDG
                     AAAAVVLHRTRTAGALPVLHEEGLRALPSRALDHLDQLRKADRWQDTDDIEQALDQIAQ
                     AADTRAQGTTVAPFGWVHSEFHPTSLHIGRRGWCLLDFARAFTGPGLLDLASWHGTLDD
                     PDPVRLRVFLESYVTEGGTPDALAERGGLPPEKWALGWHRIWAVEWFTEQSIRWISDPA
                     TDPTYIKVVRRHLTDALQLLEV"
     gene            19769..20461
                     /locus_tag="K6K39_RS23155"
                     /old_locus_tag="EASAB2608_04746"
     CDS             19769..20461
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036119.1"
                     /locus_tag="K6K39_RS23155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04746"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_221334829.1"
                     /transl_table=11
                     /translation="MLAQASPWYAHALQRTAAGPAEPLAPPARMEWTTRPGIGPGAEIL
                     GPDLRRKRVVELGCGPGHNAACLATRHAAHVTGVDLVGLQVRRARSHYGRLNNLTFVAG
                     HALHYLHASDEQFDAIYSVFGAVGLVAPELLLPAIAHRLRPGCTLAFSVPHPQRGGRPS
                     SPDDRPRRDHVTLPDRTRLPVARWDFDAARWEKHLDRAGLWLASAQEFHDPRQSRWPTT
                     LLITARKL"
     gene            20488..21063
                     /locus_tag="K6K39_RS23160"
                     /old_locus_tag="EASAB2608_04747"
     CDS             20488..21063
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009306044.1"
                     /locus_tag="K6K39_RS23160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04747"
                     /product="HAD domain-containing protein"
                     /protein_id="WP_221335624.1"
                     /transl_table=11
                     /translation="MRPPYLLLDIDGVLIPFPDEDGSIPGTHARHDVVPTGRSADDPVT
                     IWLNPAHGPMLMDVIRTGLVTPVWCTSWRRDATTLIGPLLDLPPLPHVDLPHPNITTSH
                     PNGYLWKRDHVDTWLGDARAVWIDDDFTDLDHAWATERTARGMETLLIQPDPRVGLQAE
                     HLAEVRTWIERLPVPSGAPAASSGNEAA"
ORIGIN
        1 gtcggcggtg cgcggcggca ccaccaagga ggcccggctg ctggtcaccg tccaggacga
       61 cggcgtcggc ctgcccgagg gcttcgaccc gcaccgctcg ggcaacctcg gcctccagat
      121 cgtacggacg ctggtggagg gcgagttggg cggatcgttc gacatgctgc cggcgcctca
      181 gcgggggacc cgggtgatcc tcgacattcc ggtgcgggcg cagaagtaga caactccctt
      241 acccgcagag ccgctcgggg tgtggtgagg gcagcaaaaa gccccggacc gccaggggtc
      301 cgaggctcgt gctcgttgct gctctgcttg tatcgctaag cgcatcgggg gaactgcgcg
      361 ctgcggctcg ggggcgggag atgcgtacgt gctgtgcgcg ccgccaagct caggctgtca
      421 gcaggggtgg gtatgtcagg cggaggcctg acgagcccgg ttgcgggcgg cgcggcgctt
      481 catggcgcgg cgctcgtcct cgctgagacc accccagacg ccggagtcct gaccggactc
      541 gagcgcccac tgcagacact gctcgatcac cgggcagcga cggcagacgg ccttggcttc
      601 ctcgatctgc agcagcgcag gaccggtgtt gccgatgggg aagaagagct cggggtcttc
      661 ctcgcggcaa acggcgttgt gacgccagtc catggctgct acctctcctt ggtatgactg
      721 tgcagggtgc ttgtgaatgt gaacgctttc acgaatccct caacaagtga agggccgacc
      781 gccgagtctt cacccggcgt ggtcctgtgg tttgaagagg ggttccggcg atcagtggag
      841 gccggtgttg cgggccgtcc cgatcgccac gtagagactc gcaaacctca gcggcggata
      901 caaccccttc cggaaagttt tttttgattc ctcggtgtcg actaggtcac agccgtactt
      961 ccatggggtg gatcctggcc taaacgttcg agtgaaagga ctttcgcccg ttccgctcac
     1021 acaatcacac gcagtgcacg gcgtacgcct gtgaacgtca cgctcgtacg cagcccgagg
     1081 tggtcaccgt ccatctgcag gggcaggggc accttcgaat gcaaggtgaa ctggtccaga
     1141 tcgtgcaggg acacggcgtg cttgccgtgc ggtccccgct cgggggacga agtgagcaac
     1201 tgggtgccat accgggcaac cgcggctgtc gacaggcggc tgagacccag cacgtcgatg
     1261 ccggtgtcga acgacgcctt aggcgacgta tacatggggc gattgccgag atacgtccac
     1321 ggggacgtgt tcgagactat cgccacgacc agatcctcga ccgggtccgc gcccggctgc
     1381 tccagcgtga tcgtgccgtg ccggcggttc ggctcgccga ggaactgccg gatcacctga
     1441 cggacgtaga gcgcgtgcgt cgacttcttc ccgcgctcgc gctgctgctc gacccggccc
     1501 accacgcccg cgtcgaaccc gagcccggcg ttgaacgtga accagcgggc cggcaccgcc
     1561 tcgtcctcgg tgcccggcgt gcccgaggtc agcccgaggc cgacgatccg ctcgctgccc
     1621 tggcgcagcg cgtccagcag cgcgccggtg gcctcgacgg ggtcgttggg caggcccagg
     1681 gcgcgggcga agacgttcgt ggagccgccg gggaccacgg ccaggccggg cagacggtcg
     1741 ggggcggggc cggcgtgcag gaggccgttg acgacctcgt tcaccgtgcc gtcgccgccg
     1801 agggccacca ccaggtcgat gtcgtcgctc tccgccgcct gccggccgag gtcgcgcgcg
     1861 tggccgcggt actcggtggt gaccgcctcc agcttcatct cgctcgccag ggcgtggatc
     1921 agcacatcgc gtctgcgtgc gcttgtggtg gttgccgccg gattgaccac gagaagtgca
     1981 cgcatgcatg gcagcgtacc tactgggggg tactcggccc agaccgaggt agggatcggg
     2041 taagaggcgg gggcgtgagc ctggacactc gcgggcgcgg ggggcggcgg ggcgccggcg
     2101 ggggagggct accctgctgg ggtgagcagt cagcagaaat ccgccccgga caccgccgca
     2161 tccgccgcag ccgcggagcc gcgcccgcgc cggctgacgt acgcggcggc gctggccgcg
     2221 ctggagggtg ccgccctcgc ggccggcggc ctgtgggtgc tcgtccgcgg cctcaccggc
     2281 gccccggacg accggcagca ggccgtgacc ctcgggatca ccctgctcgt cctcgcgctg
     2341 ctgccgctgc tcgccgcgcg cggtctgctg ctgcggcgga gctggagccg gggacccgcg
     2401 gtgatcaccc aggtcatggc gcttccggtg gcctacaacc tgctccaggc cgacagcatg
     2461 gccatcccgg cggggatcgc cctcgccgtg gtcgccgtgg cggccctggt cctcctcgtc
     2521 aacggagaga cgacccgggc cctcgggatc aagggtccgg gccgggccga gtaggaccgg
     2581 ccggacagga cccgcgccgc gcggtgggac cgccgcgccg ggcctactcc tcgacgagga
     2641 gcttctcccg cagctgggcc agggtgcggg cgagcaggcg ggagacgtgc atctgggaga
     2701 tgccgacctc ctgcgcgatc tgcgactggg tcatgttccc gaagaagcgc agcagcagga
     2761 tccgcttctc gcgcggcggc aggtcctcca gcagcggctt gagggactcg cggtactcca
     2821 cgccctccag cgcctcgtcc tcggcgccca gggtgtcggc gaccgccggc gactcgtcgt
     2881 ccgtgtcggg gacgtccagg gacagcgtgg agtacgcgtt cgcggactcc aggccctcca
     2941 ggacctcctc ctccgagatg gcgagcttct ccgccagctc gtggaccgtc ggggaccggc
     3001 cgtgcagctg ggacagctcg gccgtggcgg tggtcagcga cagccgcagc tcctgcagcc
     3061 ggcgcggcac ccggaccgcc cagcccttgt cgcggaagtg ccgcttgatc tcgccgacga
     3121 cggtcggggt ggcgtacgtg gagaactcca cgccgcgctc ggggtcgaac cggtcgacgg
     3181 acttgatcag gccgatcgtg gcgacctggg tgaggtcgtc cagcggctcg ccgcggttgc
     3241 ggaagcggcg cgccaggtgc tccacgagcg gcaggtgcat gcggaccagc tggttgcgca
     3301 gctccgcgta ctccgcgctg ccttccggca gagcgcgcag ttcgatgaac atcgcccgcg
     3361 ccccgctgcg gtcctgggcg tcgtgccgta cggcctgcac ggcctccgtg gccggcgtgt
     3421 cgtcctcggc gtgtcgctcg tgctcgctca tcgtcccgcc cgttgccctt ccccgagccc
     3481 tcgcacccgc gcggacggcg gttccggcgc cgtcggcggc ctccggtggc gtgccctggc
     3541 cggcatcgtc accggaggca cgcgcggagt cgtcctccgg gtgcggcctg gcctgctcgg
     3601 ggatgccgtc gatgccgtcc gccgtgcgcc gggaaccgtc ccgggggtcc gccccggagg
     3661 tctcggcgct ggtcgaccag ggggcacccc cgtccccggt cggcagctcc cgtgtgccgc
     3721 gctcttcgtc ccgcaccggc ccgtccccgt tcctcacgcc ggcccggggc cggcgccgcg
     3781 ctgtttgtag aggctgatcg agaccgtctt gtcctcgtcc acggcggacg agaccttgcc
     3841 cgcgagggcc gacagcacgg tccaggcgaa ggtgtcccgc gagggggcgt ggccgtccgt
     3901 cgtgggcgcc gacaccgtga cttccagcga gtcgtccaca agccggaaga cacagctgag
     3961 caccgagccg ggcacggctt gctggagcag gatcgcgcac gcctcgtcca cggcgatgcg
     4021 caggtcctcg atctcgtcca gggtgaagtc caagcgggcc gccagaccgg ccgtggccgt
     4081 ccgcagcacc gacaggtagg cacccgcagc cggcagccgg acttccacga agtcctggtt
     4141 cgccgcgggc tcgcctgcga tctgggacac cctcacctcc atggtggtac aagctttacg
     4201 gggccgaggg tcgccccccg gggtaacgcg tacgtggttc agcggtgacg ctatcgcgct
     4261 ccgaacgttg ctgtccccgg gaccccaacc ccctggcgtc actcacagta aagctgtgga
     4321 tacgctccgt gtctagaggg tttgcgtgcc caaatgggaa gagcgcgcgc cgggttgacg
     4381 tacccagacg tcagacgctc gaaccgtcgt gcggcagccg ccgcatgcag tgtcacacga
     4441 gaaggtggtc aggcgggacg gtctcgctcg tacgagcgca tttcagcagc tcacacgagc
     4501 acgtggtcga cgaaacacca ccgccagtcc tcgccgggct cgaaggtccg catcaccggg
     4561 tgaccggact tctcgtggtg ctccgtcgcg tgccgtcccg gcgaggagtc gcagcagccg
     4621 acgtggccgc aggtgaggca cagccgcagc tgcaccgggt gggtgccgtc ccgcaggcac
     4681 tcgggacagg tctggtcgag aggctccggt tccgggtgcg gcagcgcgtc ggcgtgcgtg
     4741 cactgtttca tgattgccag attacgacgg gtgtgcgggt ggccgcgcga agaccgaggg
     4801 tgggcgagga ccatggacgt gatgcccctg ctgttgctgg tggcgggcag tgccgcggtg
     4861 gccgcggcgg cccggcgcac ccccgcgccg gcgcccctgc tgctggtcgc ggtcgggctg
     4921 gcggtctcct acatccccgg ggtgccgtcc tacaccctcg atccgcacat cgtcctgccg
     4981 ctgctgctgc ccccactgct gtacacctcg gcgagcgaca gctcctacct cgacctgcgg
     5041 gcgcagctgc ggccggtggc gctgctctcg gtgggctacg tgctcttcgc gaccgtcgtc
     5101 gtcggctggg ccgcccatct gatcgtcccc gggctgtcgc tgcccgccgc gctggtgctg
     5161 ggcgcggtgg tggcgccgcc ggacgcggtg gccgcgacgg cggtcgcgcg ccgggtgggc
     5221 ctgccctccc ggatcaccac catcctccag ggcgagtccc tgctgaacga cgccacggcg
     5281 atcaccgcct acaaggtggc gctcggcgcc gccgtcggcg cgggggccac ctgggcgggc
     5341 ggcatcggcg agttcgcgct cgccgccgtc ggcggtgtcg gcatcggcct cgtcctcatg
     5401 gcgcccctgc actggctgcg cacgcacctg accgagcccc tgttgcagaa cacgctctcg
     5461 ctgctgatcc cgttcgtcgc ctacgcggtc gccgagcagg cgcacgcctc cggggtgctc
     5521 gcggtcgtgg tcgtcgccct ctacctcggt caccgcgcgt gggaggtcga cttcgccacc
     5581 cggctccagg agcacgcggt gtggaagatg gtcgccttcg tgctggagtc cgcggtcttc
     5641 gccctgatcg gcctgcagct gccgatcgtc atcgagcggc tcggcgcgta cgagggcacc
     5701 tccgccgtct ggtacgcggt cgccgtcttc ctggtcgtgg tggtggcccg gttcgtctgg
     5761 gtctatccgg ccaccttcct gccccggctg ctgtcggcgc gcgtcaggga gcgcgaggag
     5821 aaccccacct ggcggggcgc gatggtcacc tcgtgggccg gtatgcgcgg tgtggtctcg
     5881 ctggccatcg ccttcgccat cccgccgacc atgcccgacg gcccccgcaa cctgatcctc
     5941 ttcctgacct tcacgaccgt catcggcacc ctcgtcgtcc agggcgtgac gctgccgccg
     6001 ctgatccggc tgctgaagtt ccccggccgc gaccggcagg ccgagacgct cgccgaggcc
     6061 aacgcccagg cgcaggcctc acgggccgcc gaggcccggc tcgacgaact cctctccgac
     6121 gagcgcaacg ccctgccgcc gccgctcgcc gaccggctgc gcgcggtcct ggagcgccgc
     6181 cgcaacgccg tctgggagcg gctcggccag gtcaacccgg tcaccggcga gtccgtggac
     6241 gacacctacc gccggctgtc ccgcgagatg atcagcgccg agcgggaggt cttcgtccgg
     6301 ctccgggacc tgcggtacat cgacgacgag atgctgcgcg cgctgctcag gcgcctggac
     6361 ctggaggagg cggcggcctt cagggaggcc ggttagcgtc ccgcggcggc cggcccgggg
     6421 tccgggaacg gccgtcccgt gacgacggcg gcgatcgtcg tcccgcgcgc gaaggcgttt
     6481 tcctgcgcca gggcgacgag tccgtacagc aacttggcga catagagacg ctccacgggc
     6541 agtccgtgcc gctgctcgaa gtcgcgtgcg aacgcctcca gttccggggt cgtccgggcg
     6601 tagccgccgc agtggaagcg gtcgtccagg gaccaggtgc cggtgcgggc gccgaaggca
     6661 cgttcctgca gggtctgtac gtcggcttcc aggaaaccgc ccttcaggac cggtacgccg
     6721 agcgcgcgct gcccggccgc cagcccggcg gcgagccccg cgagggtgcc gccggtgccg
     6781 caggcgaccg cgacgacgtc ggcgtggccg cgcagttccg cgccgagggc acggcagccg
     6841 cgcaccgcct ccgcgttgct gccgccttcg ggcaccacgt acgcgccctc ggcgccggcc
     6901 gcgtgcagga tcccggccag ggtctccggg tcggtcttgc ggcggtacgt cgatctgtcg
     6961 acgaagtgca gccgcatgcc gtcggccgcg cagcgggcca gggacggatt gagcgggcgg
     7021 ccggccagct cctggccgcg gaccacgccc gtggtgggca ggcccagcag gcggcccgcg
     7081 gcggccgtgg cccgcaggtg attcgagtag gccccgccga aggtgaccag cgcccggccc
     7141 tgcgccgccg cgatgttcgg caccagcttg cgccacttgt tgccgatcag ctccgggtgg
     7201 acgaggtcgt cccgcttgag cagcagccgg agcccgcggc ggccgaaacg ttcgtcacgt
     7261 atctcgtgga caggggaggg caggcggggg gcgagcgggt ccgggctggt cacggctcca
     7321 ttgtcgtacg ggggcgggat cagggacgga ggacggggga cggaacgggg acgccccgga
     7381 gggacgcggg ggccgccctc cgcccggcgg cggtcggccc cgcggccccc gcccccacgg
     7441 cgcgctagtc cttcagccgc tcccgcaccc gctccctcat cgacgacatc gtgaacccgc
     7501 gcgggtccac cttccccggc tgccactcca ggtgaccgat gaccgaccgt tccgtccacc
     7561 cgtggtgccg gcacagtgcc gcggcgaccc gctcgatcgc ctccagctgc tcctccggcc
     7621 acgggtcctc gccgtcgccg aggttctcgc actcgaagcc gtagaagtgc cggttgccgt
     7681 cggtgttcgc ctcgttgtcc ggcggcagcc ccttctcggc gatcaccgcc cgcagcacct
     7741 cgtcgtcacc gagcccggcg tggttggcac ggccgtagcc gaccaggtgg accgtgccgt
     7801 ccttcgtgat cacgccgtgg cacagcggcc ccggcaggtc ctcgtggccg tcgcggcaca
     7861 gctccacggt gcgcgcgctg ccccgcgtca ccgagtggtg gatcatcacg ccgtggacgg
     7921 ggccccaggg acccttgtga ttgcggttgt ggtgctgcca gtcgccgacc tcgacgaccg
     7981 tgacgccctc cgctctgagt gcggccagaa atgcgctcgc cgacatgggt ggggccatgc
     8041 ccgactcctt cgtgccgtgc ccgtccggcc gccggtcgcg accggatgtt cctgcctgct
     8101 tctaccgaaa ccggacgtcc cggaacacat cgttcgcacg gtgtgcgagc cgatccggac
     8161 agccgggggt atgccgtgcg ggcgggggcg gatgcccgag cggcctgggg ccggcgccgg
     8221 gccggggcgg acgcccgggc gggccggggc cggggtcggt gttgggccag ccggggtcgg
     8281 atgcccgttc gggccggagc cgacgaccgc gcggccgggg gcgggatccc tcgttgtgcc
     8341 cactaatccg atgatccatt cccgctcttt cgggtaatgg cgccaccacg gtgcgtgctg
     8401 gaaggctcgg acgcgagacc ggtgcccgcg cgattcggca ccgggccata catgggaggg
     8461 catttcttta tgtcggtagg cgaagaggtc cgcacagagc agggcaggcc gcagcagtcc
     8521 ctcgggacgg cggcagcgcg gaacctggcc accaccacca agtccgttcc gcagatgcag
     8581 gagatcagct cccgctggct gctgcgcacg cttccctggg tggacgtcca gggcggcacc
     8641 taccgggtga acaggcggct gacgtacgcc gtcggcgacg gccgcatcac cttcgtcaag
     8701 accggggacc aggtggaggt catcccgaac gaactggccg agctgccggc cctgcggtcg
     8761 tacgaggacg aggaggtgct gacggagctg gcccgccgct gccgccagcg cgacttcgcg
     8821 cccggcgagg tgatcgccga cttcggcaac cggacggacg aggtctacct cctcgcccac
     8881 ggccgggtgg agaaggtcgg cacgggcccc tacggcgacg acgccgtgct cggcgtcctc
     8941 gccgacggcg cctacttcgg cgaccaggcg ctgatcgacc ccgaggcgat ctgggagtac
     9001 accgtccgcg cggacaccgc gaccacggtg ctgatcctca gccggcagga cttcgcgcag
     9061 gtcgcggagc gctccgactc gctgcgggcg cacctcgaac gactgcgctc gatccccgag
     9121 cagcggacca acaagtacgg ggagaaggag gtcgagctgg cggccggcca ctccggcgag
     9181 cccgacatcc cgcacacctt cgtggactac gaggcacggc cccgcgagta cgaactgagc
     9241 atcgcccaga ccgtgctgcg catccactcg cgcgtggccg acctctacaa ccagccgatg
     9301 aaccagaccg agcagcagct gcggctcacg gtcgaggcgc tgaaggagcg ccaggagcac
     9361 gagctggtca acaacccgga gttcggcctg ctcagcaact gcgagtacga ccagcggatc
     9421 cagccgcacg acggcgtgcc cagcccggac gacctggacg agctgctcag ccgccgccgc
     9481 ggcaccaagc tgctgctggc ccacccgcgc gcgatcgcag cgatcgggcg ggagctgaac
     9541 aagcgggggc tggtccccga gacgatcgac atcgccggca accgcatccc cacctggcgc
     9601 ggggtgccga tctacccgtg caacaagatc ccgatcagcg aggcccgtac gacctccatc
     9661 atcgccatgc gtaccggcga ggccgagcag ggcgtcatcg gcctgcggca gtccggcatc
     9721 ccggacgaga tcgagccgag cctgtcggtc cgcttcatgg gcatcaacga acaggccatc
     9781 atcaagtacc tggtgacggc gtactactcg gccgccgtcc tggtgcccga cgcgctcggt
     9841 gtgctggaga acgtcgagat cggccggtgg aggtgacgtt tccgcacgtc gcggccgtgt
     9901 ccgcgcccgc cggcgcgggt aggtcctcgg ggtatgcgtc cggcgagacc ggtgacgccg
     9961 gcctgcgcgg acctgacgag ggggaggcat ggccgagttc atgacggaga ccgaagagcg
    10021 tgcctccggt gtgccgggtc ccggcgcacc gggggagccg cgggagaaga ccggggaggg
    10081 gaccggcccg gccgacgcgc aggaggcggc ggcgcaactg gagcgcaccc gggccctggt
    10141 cgacccggag ctgcgcgcgg ccgtggagtc gctgcccggc tccatgcgcc ggatcggcct
    10201 ctaccacttc ggctggcagc aggccgacgg ctctccggcg gcgggcaacg cgggcaaggc
    10261 gatcaggccg gcgctcgtgc tggcggctgc cgccgcgctc ggcggaccgg cggcccggac
    10321 ggcgaccgtc cgggcggcgg cggcggtcga actggtccac aacttcacgc tgttgcacga
    10381 cgacgtgatg gaccgggaca ccacccgccg gcaccggccg acggcctgga ccgtgttcgg
    10441 cgacaccgac gcgatcctcg ccggggacgc cctccaggcg ctggctctcc ggctgctcgc
    10501 cgaggacccg cacccggcgt cggtgccggc cgcggcccgg ctcgccgcct gtgtcgtgga
    10561 gctgtgcgag ggccagcaca ccgacaccga cctggagcag cgggcaccgg aagcggtcac
    10621 cctggacgag gtgctcgcca tggccgaggc caagaccggc gctctgctgg gctgcgcctg
    10681 cgcactcggc gcgctgtacg cgggcgccgg cgaggaggag gtggccgcgc tggacggctt
    10741 cggccggcag gccgggctcg ccttccagct gatcgacgac gtcatcggca tatggggaga
    10801 cccgcggcac accggcaaac cggccggcgc ggatctcgcc gcccgcaaga agtccctgcc
    10861 ggtggtggcc gcgctcacct ccggcacccc ggcggcggtc gaactcgccc agctgtacgg
    10921 caagccgtac cgggaggagg cggcggaggc cggggagatc gcgcgcatcg cactcgcggt
    10981 ggagcgggcc ggcggccggg actgggcgca ggccgaggcg gccgaccgga tggcccgggc
    11041 catgcaggaa ctggcccgcg cggtccccga cccggaggcg gcgggcggtc tgctggcgct
    11101 cgccgagttc gtgacccggc gcaccagctg agggccccct cccggcgccc gacaaggacc
    11161 cggagtcccc ggcccgtgcg gctcctgacc ccgcacggtc accgggggct ccggtcaggc
    11221 ggccccgcac atccccacag tgtgcggggc gccgctgcgc ctcggccgca cgaccgaacg
    11281 ccggagaccg ggaccggctc gcccggcccg aacggggagc accacggtcg acctgctcga
    11341 ccgcatccgc gggtcatcga gtcccgcccc gtcgtctgcg gcaagggcat gccgatgtcc
    11401 gccaccggcc cgggcatcgg gacgtcacct atgagtccgt gcgctccttc ggcaacggcg
    11461 aaccggcgcg gacgtacggc agggagcgct gaggctgccg ccgacctacc ctgagggcat
    11521 ggacagcgag aaacacgtct gtccggtctg cggacaggcc gtcgacacgg tcgtcaagcg
    11581 gcacaagacc ctgggcgcct gggtgccggt ctggggcccc ggcccatgcc acgaccccgg
    11641 ctgcgcggcc tacgccggac ccggccggcc cgccggatcc ggccgccacg ccgacgccga
    11701 ccggtccgcc gagtccggcc gatccgccgg tgcggagaac agcggcgtct gagcaggggc
    11761 cgtcgggcca ggtgccgggg ccgtcctgct agggggcggg gcgccgtagc gtgggcgtat
    11821 gccgaagctt ccgtacatcc ttcacatcac cgagcgctcc ctgtgggagg cggcgcgcgc
    11881 acgcggcgcg tacgagatgt ccacccgggg ccgcaccctc caggaggagg gcttcatcca
    11941 ctgctccacc cgcgaccagc tcccgcgcat cgccgacttc ctctacggcg gctacgacgg
    12001 cccggaccag ctggtcgtcc tggtcgtgga cccggcccgg gtcggcgtac cagtgaagta
    12061 cgagtccgcc gagccgggcg gggaggagtt cccgcacgtg tacggcccgg taccggtcgg
    12121 ggccgtggtg gacgtggaga cctgggggtg acgcgggcgc gcgcctaccc ggcgtcggcc
    12181 gcgccctgag cggggccgac gccgggcagg ccgcccgtct ccgggtcgcg gccggtcagg
    12241 cagtacaggc cgccggccgg gtcgcgcatc accgtccagt gggcgccctc cgacgccacc
    12301 acggcaccca gcttctcgtg ccgtgcgcgg acggccggga tgtccgcgca ggccaggtcg
    12361 aggtgcgcgg aggccgggcg gtcctcgtcg agccgctgga gcagcagccg gtgcgggagt
    12421 ccggcgggcg ggcgcagtac ggtgaactcc ggccgcgagc ccggcagccg ctcccacccg
    12481 gtcagcccgg cccagaacgc ggactcggag tcgtaccggg acggcggtat gtcgaggcac
    12541 acctggtcca ggcggctgcc ggacaccacc ggcggccgta ccgtctcgcc gtgccagggc
    12601 acggcgcaga acaacagccc ggcgggggag cgcaggacgg cccagtcgcc gtggtccgcc
    12661 acgagcgcgg cgccgtgttg ccgggcgcgc ccggtcaact cccgtacgtc ctcggtgcac
    12721 aggtcgatgt gggcgccgcc ggcaccgtcg gtgacaccct ggagcttgcc gctcgggtcc
    12781 gcgccctcgg gcagcagcgt cacgaactcg ccgcggtcgc cgcggaacgc ggacagccgg
    12841 gtgccggtga cggccgtcca gaaggcgcac gcgtcggcga ggcgtgcggc ggggcggtcg
    12901 gcgaaggcgt acgtccagcg gatcgtcatc cggggagtgt aggccgggcg gcccccgaac
    12961 aggagcggat gtggcgggag ttcaggcggt ggggcgttcg atgaagcgga gctggttgcc
    13021 cgccgggtcc cggaaggcgc agtcgcggac cccgtacggc tggtccatcg gctcctggag
    13081 gacatcggcg ccggaccggc gcacccgctc gtagagcgcg tcgcagtcgg gggtggtgaa
    13141 gatgacgccc cgcagcaggc ccttggcgag gagttcgttg agcgcctgct tgtccgcggg
    13201 ggaggcgtcc gggctcgcgt ccggcggctc caggacgatc tccacgtccg gctggagcgg
    13261 ggagcccagg gtcacccagc gcatcccctc gaagcccacg tcgttgcgga cctccagacc
    13321 gagcacatcg cggtagaagg cgacggcctt gtcgtggtcg tccacggcga ggaaacactg
    13381 cgcgagtttc acgtccatgg actcacccta gatccggcgg gcgcgccccg cctcagtacg
    13441 ggcggcggcg ggggcgggtg agccggcggg ccacgcaggg cgggatcgcc gcgctctcct
    13501 cgtggtcgcg ggcgcggtag gcgctcggcg tctcgccgac cagctcggtg aagcgggagc
    13561 tgaaggagcc gagcgaggtg cagccgacgg cgaggcacac ctcggtcacg gtgagatcgc
    13621 cccgccgcag cagcgccttg gcccgctcga tcctgcgggt catcaggtag ctgtacggcg
    13681 tctccccgaa cgccttgcgg aagctgcgct ggaagtggcc cggggacatc agggcgtcac
    13741 gggccagctc ggtcatgtcg agcggctcgg cgtactcgcg gtccatacgg tcgcgcacac
    13801 ggcgcagccg cctcagatcc tccagcgcgg tcacccgcac agcttcgcac aggccgggcc
    13861 gcgcgggacg atctcctccg gcagcaccgc cggacacgac accggcccgc ccggcagggc
    13921 cgggcgggcc ggtgtcacac cgacttcgcc ccgcggcacc aaggcaccgc gggggcgaga
    13981 tcaaggggcc tcggttcagg ccttcttggt ctcctagtaa tgggccgggt cggtgacctg
    14041 cagcgatggt tgctgcaggt cgctgacctg gcctcttgct gttggccagc gatggggtgt
    14101 gacggtcgct gttgggtgtt ctgcggactg tgtgcggact ggcccgcggc cggcgaagag
    14161 tcgtgcgctc gcacacgtcg cctgtcaggg ctagatgaga tgcactagga gcttgagggg
    14221 tgctgtttga tcagggctcg agacagaatg ccagccacct cctcggctcc cgtatccagc
    14281 gcggccaggc tcatggactc atccggctcg gtttgcagcg tgaatgagcg ggtgtaggca
    14341 ctgagatcgg cacgggtacg tgactgatgc gggttaaatc tgtcgatctg ggtcattttc
    14401 ggatttgata cgccgatcgc cacaacgatg cgctcacttt ggattaggtc cagtgcgccg
    14461 ttaaatctca gcagggaggc gacttgctgg ggcagcgcgt cgtgatcgag gatggacccc
    14521 atattgtctc gggggagggt tgctcgcagg gagacttggc ccgacttgta caagcgaacc
    14581 tccactagtt caccatgctg aggagcatca aaggcgcgag gtcgagcaac ggagattccg
    14641 acgattgcgt gctctcggga gcttgatgac gttagggcga cgctgctttt gaccgccccg
    14701 gcccggcgga tccggtccgc cagcgaggtg ccaagttcgt cgagttccct tgccgagtag
    14761 cccggaaacc ccaccggaag aacatgtagt tccaacaagg gaaggctggt gtcaacgtcg
    14821 acgccagcct ggtcgaggct ccaacgcaga gaaacgggct gcgtcaaggg ggcaaaggac
    14881 aatggggacc ggtctgactc cacttcttta atcttggcta cgactttggt cattagctcg
    14941 gccgtgttgt gaaatgagtc gcggaacccg ccggtggcgt aagcctccac cgttcgggcg
    15001 aaatcctgtt gggcgttctc gaaggtgacg cccaacttcc gatagaccca gcgcggcttg
    15061 cccgctgtct tggccgcgac ccactcatcg tgtgttgctg attgccctgt ctcggggaag
    15121 acgtgaccgt aggacggccc gagcaggaag acacaaacgt ctgcggagtc gagggcggct
    15181 aggcacgcct gcctgctggg tgtggtctgc gcggagaagt cctcgaacag gacaggggtg
    15241 tgtccaaccg cgcgaatgag gccaggcagc gcgtcgcgct cctcctccag tcccttgcgg
    15301 acgctgctga tgaagattct cacgctacga tctccattac tgaagggttc ggtgaagcga
    15361 accggacggc caatgagtgc ctgggataag ggggttgctt catggctgaa gtctcggatg
    15421 aggcgatacg cgcctactgg aaggagcacc gggagcagct acggcagtgt gagactcaac
    15481 gctcgacact gagcagcctt cttctcgtta tcactgctgc cttgagtgct ctcattgtcc
    15541 agcagaagtt ctcgacgtac gtcatgcctc tgtgtctttt cgtggcgttg actggaggat
    15601 acggggcggt ggcggtctcg aagtatttcg aacgggcgtc ctatcatctt tctcaggcgc
    15661 gagccctaac caaagatttg gtggagctgg gtgtgctggg ctctgacgaa agactgatac
    15721 gtgcaaggga tgatcactac cgtctttttc ctcggctgca tcgcattcgt cttcatcgcc
    15781 tgtgggtgat tcttcacctt gccatcgccc tgtacggact ttgcctattt ggcatatgtg
    15841 tggttgtagt gtgatgtccg gtattgtgcg ttttgctggt ggggcttcgg cggccgtttc
    15901 agttcatcaa gggcaagccc ctatccccag ccatcgaggg agacttccgg accacccatg
    15961 aggtagcggt agagggcact tgcggttgtg ttcacgaact ccgtagggat cgcgtcgaca
    16021 tcgacccagc aaacctgggc gtgcttgcgc ggctcgcggt tttctggttc gcccgtccac
    16081 tcgtgggcgg cgaagacgac ggtgagaaag ccattggggg cctcgacgcc gctggcgccg
    16141 tggatgatgt gtgcgacctt gagggactgg ggcttcacgg tgaggcccgt ctcctcgtag
    16201 agctcgcgga ccgcggtttc ggtgatgggc tcgcccggct cgcttttgcc gacggggagg
    16261 tcccacattc cctgggcgaa cttcgcgttc tcgctgcgtt ggagaaggac cacgcggttg
    16321 gcggttttgt cgtggacgat gacagcggcg accagcaggg tcatcgattc gagcgccggc
    16381 ttcagggcct tcggctggtc gcctgtctgc tgggtcacgg tgttcccttc gtcgggcgcg
    16441 ttgttgggca tgttaggcga gggcctcgcg ggcgcggcgg gcgagatcgg cggcgccggg
    16501 cactttgcgg cgctggtaga ccgcgagggt ggagcggatc gaggtgatcg ccttgagagt
    16561 gcggtcggag gtcatgcctt ccatgaggac cagggcctgc gtccaggcgg cgaccgcttc
    16621 gtcggcgcgg gcctgtgcgg cgaggctgtc gccgaggtcg gcgtgggtga gggcgtggac
    16681 gcgcttgtac ttcgcagggt cccagcgggt gagggcgtcg cggtgctgct gttcggtgcc
    16741 gatgtggtcg gcgaggtcgg tcagggtgcg ggcggtgtgg ctggccacgg tgccggcggc
    16801 agggccgctc acgagggagt agctgggctg ggggccgtcg tctcgtagga gggcgtcttc
    16861 ggcggcgagc agggcgcgtg cggcttgggg gttctcgttc acggcggcgt aggcgcgggc
    16921 gtgggtgatg tggaggagcg cctcggtccg gccgtcgatg tggccgagac ctgcgcgtag
    16981 ggcgccttcg acgaggtcga cgcagtggtg gggctgcttg aggctgaggg cctggtgggc
    17041 gagggcgcgc atcatccagg cggcgtggcc gtgggggtcg gcttcgcagg cgagctggta
    17101 gccgacttgg tagtagcgct gggcggcgcc ttcctggccg aggtcgtggt gcttccatcc
    17161 tgcaaggtag gcgagttcgg cgacggcgcc gaaagcggcc cggcgtaagg cttcgctggg
    17221 gaagcgtccg cgcagcatgg gggcggctgt gtcggcgagg tacgcggtga cggtggtcag
    17281 gccgtgcccg ccgccgaggc gctcgtcggc ggcgctgaag gctgcggtga tctggcgtac
    17341 gacgtccacg tcctccgccc cgaccaggga cgtgccggtg cgggcgcgaa gcatccgggc
    17401 ggcggcctcg tggtcgtacc cgaggggcat ggcgacgcct gcggtggtga aggccgcgat
    17461 ggcgaggaag cggcggcgtt cgacgtcggc gcggcccagg tcggtgacgg cgaggacggg
    17521 gtcggattcc gccggctctt cgttatcacc ggtctggagg ccgatctcgg tctgggtgat
    17581 cgtgcgcccc gctcgacggg acagcgcctc ggccaggtac tggcctaccc ggcccgacgg
    17641 ggcacgactg ccggtcaccc agtgcgagat ggccgacttg ttggtctgga ggatctcgcc
    17701 gttctcggcg gcgatgcgtc gcacgtctct ggcgagggcc tcgtaggtgc agtcgaccgc
    17761 cacaatggcg tcgcgcagac gggagttggg gtctctctgc gccgtcacga tcgcctccgt
    17821 cctggagctg taaaccgcgt ataccgcttc aactgccttc caccgtaccc actgagcgtg
    17881 accaccggtt cacttatcag cagccgcccg gaacggtgcg accgtgatcc aggctccccc
    17941 ttggtccggg cggcccccca aagttccgta cgccacaccg ggctcgggca ttcctgtgcc
    18001 tggacccggc cgatcagaga cggagacacg gtgaccacca tcgacaccac ggccatcacg
    18061 gtcgagctgc ccgaagcgtt cgacgagcgc tggagccgcc tgccgggcat tcaggtcgac
    18121 ggccggcgca tcacgatcga cccggccgag tacttcttcc gcttcgagtc gagcacctgg
    18181 ctcgtcgccg actgggagct ggtcaagtcc cagctcctgg acgtggagga gaccgccgag
    18241 agcgcggtcg agcagctcgc gctggacttc atcaaggctc atggcgagtc cacctcgaac
    18301 gccgcccgcg tgctgtccac cgcgtacgag gtgtacgcct acctgttccg cgacgagcac
    18361 ctcgccggcc tcggcctgcc acagatcacc gccgagcatc tgcgcatgct gcgcgaggcc
    18421 gccacgctga tggcgctcaa caaggtcgag ctggacggac acatttccaa cgtcggaccc
    18481 tgctggttct tccccgccgc cacctcggtc gtcttcgacc tggacgacga gatgggcggg
    18541 atgctggacg aggtctacca cggcggctgg ttcaacgagc accgccgcat cgagtccatc
    18601 aaggcccacg ccgcgctcgg cgggcggctg gtacacggtt gccagtccgt gccggatcag
    18661 tccggcggcg tcgtcgcgcc ctacggtgcg tcgatggcga acttccgtga cgacctggcc
    18721 gccttcaagg ctggctggat cgagcaggtc tacgcccacc gcgtgacccc tgccgcgtaa
    18781 cacccagcaa cccggctccg gggcgggcag gcacgctcgc ccaccccgga cgccaccaaa
    18841 acgcaacgga gaccccgtga acaacaacct gaccaccgat ctcctcgcca acctgtgcac
    18901 cctcgtcgac cagcccagtg ccaagcggga ggaggtgagg gtgtggtcga tgtccggcgt
    18961 cgagcgcgtg accttccccg acggcagcac gcggatcttc aagtacgcca agaggccctt
    19021 cgacagcgag gaccaggccc tgcggctggc cgacaccctc ggcatccctg ccccgaaggt
    19081 ctacagctca gtccggatcg agggctggct cggcatgcta ctggaggacc tcggtacccc
    19141 catccgggaa gcggacgacc tcgacggcgc cgccgcggcc gtggtcctcc accgcacccg
    19201 caccgccggc gcgctgcccg tactacacga ggaagggctg cgtgccctgc ccagccgtgc
    19261 cctggaccac ctcgaccagc tccgcaaggc cgatcgctgg caggacaccg acgacatcga
    19321 gcaggccctc gaccagatcg cccaggccgc cgacacccgc gcgcagggaa ccaccgtcgc
    19381 tccgttcggc tgggtgcact ccgagttcca ccccaccagc cttcacatcg gccgacgcgg
    19441 ctggtgcctg ttggacttcg cccgcgcttt caccggccct ggcctgctcg acctcgccag
    19501 ctggcacggc accctcgacg accccgaccc cgtacgcctg cgcgtcttcc tggagtccta
    19561 cgtcaccgaa ggcggtactc ccgacgccct cgccgagcgc ggcggcctgc cccccgagaa
    19621 gtgggcgctg ggctggcacc gaatctgggc cgtcgagtgg ttcacggagc agtccatccg
    19681 ctggatcagc gaccccgcca ccgaccccac ctacatcaag gtcgtacgca ggcacctcac
    19741 cgatgccctc cagctcctgg aggtgtaggt gctcgcccaa gcctcgccgt ggtacgccca
    19801 cgcccttcaa cgcaccgccg ccggcccggc cgagccgctc gccccacccg cacggatgga
    19861 gtggaccaca cggccgggca ttggccccgg agccgaaatc ctcggccccg acctgcgacg
    19921 caagcgagtg gtggaactcg gctgcggccc cggccacaac gccgcctgcc tcgccacccg
    19981 gcacgcagcc cacgtcaccg gcgtcgacct ggtcggcctg caagtccgcc gcgcccgctc
    20041 acactacgga cggctgaaca acctcacctt cgtcgccggc cacgccctgc actacctgca
    20101 tgcctccgac gagcagttcg atgcgatcta ctcggtcttc ggcgccgttg gcctcgtggc
    20161 gcccgaactc ctgctcccag ccatcgccca ccgcctcagg cccggctgca cccttgcctt
    20221 ctcggtaccc catccccagc gcggcggccg accttcctcc ccagacgacc gcccccgccg
    20281 cgaccacgtc acgctgcccg accgaacccg cctgcccgtc gctcgctggg acttcgacgc
    20341 cgcccgctgg gagaagcacc tcgaccgtgc gggcctgtgg ctcgcctcgg cccaggagtt
    20401 ccacgacccc cgacagagcc gctggcccac caccctgctc atcaccgcgc gcaagctctg
    20461 accctcggct cccccgtgga ggaatcgatg cgcccgccct acctgctcct cgacatcgac
    20521 ggcgtcctca tacccttccc tgacgaggac ggctcgatcc cgggcaccca tgcccgtcac
    20581 gacgtcgtcc ccaccggccg cagcgccgac gacccagtca ccatctggct caaccccgcc
    20641 cacggcccca tgctcatgga cgtgatccgt acgggcctgg tcacaccagt ctggtgcacc
    20701 agctggcgcc gcgacgccac cacgctgatc ggcccactcc tcgacctccc gcccctgccg
    20761 cacgtcgacc tgccacatcc caacatcacc accagccacc ccaacggcta cctgtggaag
    20821 cgcgatcacg ttgacacctg gctgggcgac gcacgcgccg tgtggatcga cgacgacttc
    20881 accgacctcg atcacgcctg ggctacggag cgcaccgccc gtggcatgga gaccttgctg
    20941 atccagcctg atccccgtgt cgggctccag gctgagcact tggccgaggt ccgaacgtgg
    21001 attgagcggc tgcccgtgcc gagtggtgca cctgccgctt cgagtggaaa cgaggcagcc
    21061 tgacgggctc gcgtgccagc agggtcgtgc cctcgccacg gggcgtggcg agggcaacgg
    21121 accggggcta g
//
