LOCUS       NZ_AP024135            21026 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5116130
            Orig. end                         :: 5137156
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21026
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21026
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21026
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11026](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11026
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(207..1538)
                     /gene="aroA"
                     /locus_tag="K6K39_RS22935"
                     /old_locus_tag="EASAB2608_04698"
     CDS             complement(207..1538)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674885.1"
                     /locus_tag="K6K39_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04698"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_221334819.1"
                     /transl_table=11
                     /translation="MAPNTAPPALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGALRAMGVEIEETVSSSSSAGGGTGEAWRVLPTGLRGPATVD
                     VGNAGTVMRFLPPVASLADGPIRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPL
                     TVHGGGALDGGPVSIDASSSSQFVSALLLSGPRFNQGVEVRHTGASLPSMPHIRMTVDM
                     LRAVGAQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALVTGGKVLIPD
                     WPSRTTQPGDRLREIFTEMGGSCELTEYGLEFTGSGAIHGIDVDLGDVGELTPGIAAVA
                     ALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRPLHGGIFHTY
                     EDHRMATAGAVIGLAVEGVQIENVATTAKTLPDFPELWTGMLGQ"
     gene            complement(1567..2289)
                     /locus_tag="K6K39_RS22940"
                     /old_locus_tag="EASAB2608_04699"
     CDS             complement(1567..2289)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674886.1"
                     /locus_tag="K6K39_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04699"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_059252521.1"
                     /transl_table=11
                     /translation="MDSLAATALPDLWDRLTGTQPDPDLWVVLATLAAALAVVVPHPLW
                     RMSRNAITIAHEGGHGLIALLTGRQLTGIRLHSDTSGLTVSRGKPYGIGMILTAAAGYT
                     APSLLGLGGAALLAAGRITLLLWAATALLAAMLVMIRNAYGVLTVVLTGGAFLLVSWLA
                     GPQVQAAFAYAVVWFLLFGGVRPPFELQAKRSRGSAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSLCSLVGGGRWLLEG"
     gene            2340..3155
                     /locus_tag="K6K39_RS22945"
                     /old_locus_tag="EASAB2608_04700"
     CDS             2340..3155
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="K6K39_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04700"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_086700256.1"
                     /transl_table=11
                     /translation="MCGRYASSRRPEDLAGIFEIEKWEPEETLEPDYNVAPTKEVYAVL
                     DRPLKDADSPRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPAYRRAFAARR
                     CILPADGYYEWVTGTQERELEVEGKKKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAERTPLAVAPAEGPHSLAEIHPRMPLMLTPDRWDAWLDPART
                     DPDDLRGLLAPPPAGLMRAYPVATAVSNVRNNGPELLKELEAPEEGTLF"
     gene            3194..3820
                     /locus_tag="K6K39_RS22950"
                     /old_locus_tag="EASAB2608_04701"
     CDS             3194..3820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="K6K39_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04701"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_221334820.1"
                     /transl_table=11
                     /translation="MSEIVETEAGDARITWHEAKRARLVLAASHGAGGGIEARDLQALA
                     AALPAHGVTVALVEQPWRVAGKKVAPAPKTLDTGWRGVWPALAGPGLPVISAGRSAGAR
                     VACRTAAELGAHAVLALSFPLHPPGKPEKSRAEELLGAGVPTLVVQGGNDPFGRPAEFP
                     QGAYDLVEVPYGDHGFAVPKRAEITQERALEILTGAVREWVASLG"
     gene            4130..4825
                     /gene="sigR"
                     /locus_tag="K6K39_RS22955"
                     /old_locus_tag="EASAB2608_04703"
     CDS             4130..4825
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="K6K39_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04703"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_059252524.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAELPEGQGASADASGETTAERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGE
                     SNEAKGSGS"
     gene            4822..5133
                     /gene="rsrA"
                     /locus_tag="K6K39_RS22960"
                     /old_locus_tag="EASAB2608_04704"
     CDS             4822..5133
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="K6K39_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04704"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_059252525.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFQHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPADLRAKVMGRIELIRSGQTVPEHDVTKAPAAPQES"
     gene            5258..6562
                     /locus_tag="K6K39_RS22965"
                     /old_locus_tag="EASAB2608_04705"
     CDS             5258..6562
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674892.1"
                     /locus_tag="K6K39_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04705"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_086700259.1"
                     /transl_table=11
                     /translation="MDAVPARARGYVAAVAVPAVLCLLPAPAEDTSWRALGLLAALYAA
                     CEHAVRRRFGGPFYPVLLAGAFLLPPSAAALVAVPAALLSPVEHRPALLRRVWRAAQPA
                     LAVWAAARVHGALGGRDAVAGSDFPYALLPAGAAVLAFCTVLTALDGGLRAAAGPVPPR
                     RAWRGLLARSLAPVAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWVFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGQASVLIARELGMDDERVEMLRFAGILHDVGK
                     LGVPTRLLRKNGPLTPEERRIIELHPEYGHEMVRGISFLGEARAAILHHHERLDGSGYP
                     YGLAGDRIPECARIVAVADAFDAMTSTRCYSRARPVEAAVAELERCAGAHFDPRMVGAL
                     VRALRRYGWHPTVTAEEPARDTPPVQRTARTGVPR"
     gene            6559..7854
                     /locus_tag="K6K39_RS22970"
                     /old_locus_tag="EASAB2608_04706"
     CDS             6559..7854
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674893.1"
                     /locus_tag="K6K39_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04706"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_086700261.1"
                     /transl_table=11
                     /translation="MTVLRLIHSAAALVSAACLTVTLWTGLHDRGVALAFGVLVTAGEL
                     TRWSDAEGRRQAAPLGAACSLAYALLGADDGRPSQHDAAQVVTVVLVATVLGAVPHIWS
                     GHSPTADHLARRVLTVGFAAVCFQPLYNQGVFALWSGPAYALLLLTLLALTSLCGAVLA
                     AALAHCRTRWPFGPLLREELRGLLGIGSAVCATGAVMALAVAVVGLWALPVFCLPMLLV
                     QLSLRRYAAVRATYRQTIASLARATEIAGCTPAGHAHRVAALSQAVGRDLGLTGPELTV
                     LEYAALMHDIGQLSLVDPVPGGATSGLPAAEQRRIALLGGAVVRQTGVDPAVAVVVERQ
                     ADPYPEQPLAARIVRAVNAYEEKARDAGPEGPLRALEELRLGSAGSYAPEVVESLARVL
                     ARPRGWRGTAPAPGGGRRTGLSDPVPGWVTHG"
     gene            7955..8932
                     /locus_tag="K6K39_RS22975"
                     /old_locus_tag="EASAB2608_04707"
     CDS             7955..8932
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="K6K39_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04707"
                     /product="hypothetical protein"
                     /protein_id="WP_059255226.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGASAAEPVGMELGSAAVRLSPEGEAEVVWGRRLDPARLEVLSIPLP
                     SSGRRWGEVVLHDGVPHGERTTSTGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRDA
                     LEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEPGHPGPLGHRT
                     DGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            8998..9648
                     /gene="def"
                     /locus_tag="K6K39_RS22980"
                     /old_locus_tag="EASAB2608_04708"
     CDS             8998..9648
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="K6K39_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04708"
                     /product="peptide deformylase"
                     /protein_id="WP_059252528.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVIDTEDCEERETAWRERGTSRPIT
                     VVGNPVLHKECKDVTEFGEELQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD
                     EGVRHVGVVCNPKLVDLPAERRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDERGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENEPRYPVVAND"
     gene            10001..11026
                     /gene="cyc1"
                     /locus_tag="K6K39_RS22985"
                     /old_locus_tag="EASAB2608_04709"
     CDS             10001..11026
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980387.1"
                     /locus_tag="K6K39_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04709"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_202431014.1"
                     /sec_met_domain="T1TS (E-value: 2e-60, bitscore: 204.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALPVIESAFPRQLHPYWPRLQEKTRCWLLEKRLMPADKVREYAD
                     GLCYTDLMAGYYTGAPDEVLQAIADYSAWFFVWDDRHDRDIVHGRAGDWRRLRYRLHTA
                     LDAPRHHLHHPDPLVAGFADSVLRLYGFLPATWNQRFARHFHAVIEAYDREFRNRTEGY
                     IPGVDEYLALRRLTFAHCIWTDLLEPSAGCELPDHVRKNPAYRRAALLSQEFAAWYNDL
                     CSLPKEIAGDEVHNLGISLITHGGLTLEEAVDEIRRRVEECISEFLDAEQKALGFARSL
                     DDGTVRGAELSAAVHSCVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVTNEAAGE
                     K"
     gene            11023..12411
                     /locus_tag="K6K39_RS22990"
                     /old_locus_tag="EASAB2608_04710"
     CDS             11023..12411
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674897.1"
                     /locus_tag="K6K39_RS22990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04710"
                     /product="cytochrome P450"
                     /protein_id="WP_059252530.1"
                     /sec_met_domain="p450 (E-value: 2.6e-67, bitscore: 226.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVKPHTPGTPGAPAASALREPPLAGGAVPVLGHGLRLVRDP
                     LAFMSGLREHGDVVRLRLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGKEG
                     VATANGPRHRRQRRTIQPAFRLDAIPGYGPVMEEEAHALTERWRPGETIDCTSESFRVA
                     VRIAARCLLRGDYMDERAERLSVDLATVFRGMYRRMVIPLGPLYRLPFPANREFNRALA
                     DLHLLVDEIVAERRASGQKPNDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETVA
                     STIMWLLQVLAEHPEHAEKVRTEVESVTGGRPVGFEHVRSLTHTNNVVVEAMRLRPAVW
                     ILTRRAVTDTSLGDYRIPAGADIVYSPYAIQRDGRSYARHLDFDPDRWLPERAKEVPKY
                     AMSPFSVGNRKCPSDHFSMTQLSLITAAISAKYRFEQVGGSDDTTRVGITLRPQNLLLR
                     AMPW"
     gene            complement(12431..13393)
                     /locus_tag="K6K39_RS41740"
                     /old_locus_tag="EASAB2608_04711"
     CDS             complement(12431..13393)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544423.1"
                     /locus_tag="K6K39_RS41740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04711"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_059252531.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLDGVHPFELGVVCEVFGIDRSDDGLPVYDFAVVSAE
                     GPELGTHCGFTVSTPYGLDRLDEADLIAVPAGETYAQREYPEELLAALRRAVDRGTRVL
                     SVCSGVFVLAAAGLLDGRRCAVHWHHAEQLARRYPRLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANKIARRMVVPPHRDGGQAQFIERPLPKAPCDTVGEVLAWME
                     AHLDQEVTVEQLAARAHMAPRTFARRFQQETGTTPYRWILRQRVLLAQELLEGTDETMD
                     AIAWRTGFGTAAALRHQFVRALGTTPHAYRRAFRGPQAA"
     misc_feature    13503..13518
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            complement(13642..14655)
                     /locus_tag="K6K39_RS23000"
                     /old_locus_tag="EASAB2608_04713"
     CDS             complement(13642..14655)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="K6K39_RS23000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04713"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_059249051.1"
                     /transl_table=11
                     /translation="MTTRPQNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLTPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPDDRAAAFAAVENIPSIREKAEFCFKWINEVEKIDRLETKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPDLFDDQLQQQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVHGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14655..17024)
                     /locus_tag="K6K39_RS23005"
                     /old_locus_tag="EASAB2608_04714"
     CDS             complement(14655..17024)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="K6K39_RS23005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04714"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_221334821.1"
                     /transl_table=11
                     /translation="MTIAPADPASVSELETDGPGTALLRTLTELTADLPDADPGRVAAA
                     ALRGRSARADEAELRELATEAAAGLIAEDPAYSKLAARLLTLTIRDEAASQGVTSFTES
                     VAVGHREGLIADRTAEFARLHAARLDALIDAAADDRFGYFGLRTLYSRYLLRHPITRKV
                     IETPQHFMLRVASGLAEDDTARSVDEVASLYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE
                     FMRRVNADGQWSLFSPADVPELVDLWGEEFDAAYRKAEAAGLAKKTIPARELYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTAEPGNVVHSSNLCTEILEVTNDGETAVCNLGSVNLGA
                     FVQDGGIDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVFF
                     KLRLPFDSPEAKALSTRIAERIMLAAYEASADLAERNGPLPAWEQTRAARGVLHPDHYD
                     VDLTWPERWDALRKRVAETGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLS
                     GEFLQVNSYLVQDLKDLGVWDARTREALRDSNGSVQDFLWIPEEIRALYRTAWEIPQRG
                     LIDMAAARTPFLDQSQSLNLFMETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIARA
                     AQGQAQAAKPIPVQQAVDPDAIACSLENPESCEACQ"
     regulatory      complement(17149..17290)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17270..17284)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(17301..17315)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17560..19188)
                     /gene="mctP"
                     /locus_tag="K6K39_RS23010"
                     /old_locus_tag="EASAB2608_04715"
     CDS             complement(17560..19188)
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="K6K39_RS23010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04715"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_059252533.1"
                     /transl_table=11
                     /translation="MNDGVNGVALGVFIFFFLAVTVMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHRHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EDTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDDIFAKAGEAFNQVNPVTEKPRGAIAPPEAGQWTYATLALGSALALFMYPHSITATLS
                     SKSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVTNGQLAIPQLFEDMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFLKPDATAEQETRVSKLVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTAAAY
                     GIASPTQKHFGGNAKEIPGIGEIGYIGLTAFVLNVLVTVVLTVVLKALKAPEGLDETKP
                     EDYTADAGDPGVEVELPPATAGAGH"
     gene            complement(19185..19448)
                     /locus_tag="K6K39_RS23015"
                     /old_locus_tag="EASAB2608_04716"
     CDS             complement(19185..19448)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925869.1"
                     /locus_tag="K6K39_RS23015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04716"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_189397060.1"
                     /transl_table=11
                     /translation="MSETPEVRPPVVTPVRVIIALCLVAPFVAMLWVGSYAKTDPTFIG
                     IPFFYWYQMLWVLISTVLTMIAYKLWQRDQRGRKGANGGAAK"
     misc_feature    complement(19519..19533)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     gene            complement(19572..20333)
                     /locus_tag="K6K39_RS23020"
                     /old_locus_tag="EASAB2608_04718"
     CDS             complement(19572..20333)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="K6K39_RS23020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_04718"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_059252535.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEAGTTRTARVPKYYRLKKHLLDMTETQAPGTPVPP
                     ERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQ
                     GLEPTSQLLDIGYITADERLAELLDIAAGGRVLRIERLRMANGEPMAIETTHLSAKRFP
                     ALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHS
                     LDREGKPVEWVRSVYRGDRYKFVARLKRPAE"
     misc_feature    20470..20485
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.49"
                     /tool="antismash"
     misc_feature    20601..20615
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 cagctcgcgg gccttcatcg ccagcacggt ccggtcctcg accagacagg tcagccggcc
       61 ccggtcgacg gtgaggacca tcccctcggc cgcgtcctcg tgcttgggcc ggatgttcgt
      121 ccgcggccgg ttgcccttgc ggttgggacg gctgcggatg tcgtcctcgt cggtgtgctt
      181 gccgtagcgg cgcatgacgt ccgtccctac tgcccgagca tcccggtcca cagctcgggg
      241 aagtccggca gggtcttcgc cgtcgtcgcc acgttctcga tctgcacgcc ctcgaccgcc
      301 aggccgatga ccgcgccggc ggtcgccatg cggtggtcct cgtaggtgtg gaagatcccg
      361 ccgtgcagcg ggcgcgggcg gatgtgcagc ccgtcggccg tctcggtgac gtcaccgccc
      421 agctcgttga tctccttggt gagcgcggcc agccggtccg tctcgtgcag ccgcagatgg
      481 gccacgcccc gcagcgtcga gggggagtcg gcgagggcgg cgaccgccgc gatgcccggg
      541 gtcagctcgc ccacgtcgcc caggtccacg tcgataccgt ggatcgcacc cgaaccggtg
      601 aactccagcc cgtactcggt gagttcacag ctgccgccca tctcggtgaa gatctcccgc
      661 agccggtcac ccggctgggt ggtgcgggac ggccagtccg ggatcagcac cttgccaccg
      721 gtgaccaggg ccgccgccag gaacggctgc gcgttggaca ggtccggctc gatcgtcagg
      781 tcccggccga gcagcgcgcc cggcgtcacc cgccacacgt tcggctcgcc gcccgactcc
      841 ggggtgtcca cctgggcgcc gaccgcgcgc agcatgtcca ccgtcatccg gatgtgcggc
      901 atcgacggca gcgaggctcc ggtgtggcgg acctcgacgc cctggttgaa gcgggggccc
      961 gagagcagca gcgccgacac gaactgcgac gacgaggagg cgtcgatcga caccgggccg
     1021 ccgtccagcg ccccgccgcc gtgcacggtc agcggcagcg cgccccggcc gtcgtcgtcg
     1081 atccgggcgc cgagcacccg cagcgcgtcg atcacaccgt ggaggggacg ctcgtacgac
     1141 cgcgggtccc cgtcgaaccg gatcgggccg tcggccagcg aggccaccgg cggcaggaac
     1201 cgcatcaccg tgcccgcgtt gccgacgtcg accgtggccg ggccgcgcag gcccgtgggc
     1261 agcacccgcc aggcctcgcc ggtaccgccc ccggcggagg agctggacga caccgtctcc
     1321 tcgatctcca cgcccatggc ccgcagggcc ccggccatca gcagggtgtc ccgggaccgc
     1381 agcgggcggc gcagccagcc gggctcggag gccagggcgg ccaggaccag ggcgcggttg
     1441 gtgaccgact tggaccccgg cacgtggacc gtcgcgtcga cggctccgct cgcgtgcggg
     1501 gcgggccaga gggcgggagg ggcggtgttc ggggccatgg ggccacttta taaggagggc
     1561 ccggtctcaa ccttccagca gccagcgccc cccgccgacg agcgagcaca gcgacaccgc
     1621 gtggaacagg aacagccaca gccccgccgg tacgtgcgtc agccgcgaca gctggtccgc
     1681 gtccgagtcg cccgcggagc cccgggaccg cttggcctgc agctcgaacg gcggccgtac
     1741 cccgccgaac agcaggaacc acaccaccgc gtacgcgaac gcggcctgca cctgcggccc
     1801 cgccagccag gacaccagca ggaacgcccc gcccgtgagg accacggtca gcacgccgta
     1861 cgcgttgcgg atcatcacca gcatcgccgc cagcagggcg gtggccgccc acagcagcag
     1921 ggtgatgcgc ccggcggcca gcagcgcggc cccgccgagg cccagcagcg agggggcggt
     1981 gtatcccgcg gcggccgtca ggatcatgcc gatcccgtac ggcttgcccc ggctcacggt
     2041 cagcccgctg gtgtcggagt gcagccggat gccggtgagc tgccggccgg tgagcagcgc
     2101 gatcagaccg tgcccgccct cgtgcgcgat ggtgatcgcg ttgcgggaca tccgccacag
     2161 cgggtgcggc acgaccacgg cgagcgccgc ggccagggtg gccagcacca cccacagatc
     2221 ggggtcgggc tgggtcccgg tgagccggtc ccagaggtcg ggcagcgcgg tggcggcgag
     2281 gctgtccata atcttcaggt ggctcctgtg gtcgtaccga gtctggcagt gtggcacgta
     2341 tgtgcggacg gtatgcatcc agtcgtaggc ccgaggatct cgcggggatc ttcgagatcg
     2401 agaagtggga acccgaggag accctggagc cggactacaa cgtggcgccg accaaggagg
     2461 tctacgccgt cctggaccgc cccctgaaag acgcggactc cccacgtccg gttcgccagc
     2521 tgcgcaagct gaagtggggc ctggtcccgt cctgggccaa gacccccgag ggcggcgccc
     2581 ggatgatcaa cgcccgcgcg gagaccgtgc acgagaagcc cgcctaccgg cgcgccttcg
     2641 ccgcccgccg ctgcatcctg cccgccgacg gctactacga gtgggtcacc ggcacgcagg
     2701 agcgcgagct ggaggtggag ggcaagaaga agcggccccg caagcagccg tacttcgtgc
     2761 tgcccgccga cggctcggtg ttcgccatgg ccggcctgta cgagttctgg cgcgaccgca
     2821 ccctgcccga cgaccacccc caggcctggt gggtcacctg ctcggtgatc accacggagg
     2881 cggagcggac accgctggcg gtcgcccccg ccgagggccc gcactcgctc gccgagatcc
     2941 acccccggat gccgctgatg ctcaccccgg accgctggga cgcctggctc gaccccgccc
     3001 gcaccgaccc cgacgacctc cgcggcctgc tcgccccgcc cccggccggc ctgatgcgcg
     3061 cctacccggt cgccaccgcc gtcagcaacg tccgcaacaa cggcccggag ctgctgaagg
     3121 agctggaggc gccggaagag ggcacactct tctgacactc tcccttccga cacccttctg
     3181 acacccttct gacatgagcg agatcgtcga gacggaggcc ggggacgccc ggatcacctg
     3241 gcacgaggcg aagcgggcgc ggctcgtgct cgccgcgagc catggcgcgg gcggcggcat
     3301 cgaggcacgc gacctccagg cgctggccgc cgcgctgccc gcgcacggcg tcaccgtcgc
     3361 cctggtcgag cagccctggc gggtggccgg caagaaggtc gcgcccgcgc cgaagaccct
     3421 ggacaccgga tggcgcgggg tgtggcccgc gctcgccggg cccggcctgc cggtgatctc
     3481 cgccggccgc agcgcgggcg cccgggtggc ctgccgcacg gcggccgagc tgggcgcgca
     3541 cgccgtgctc gccctgagct tcccgctgca cccgccgggc aagccggaga agtcccgcgc
     3601 cgaggagctg ctgggcgccg gtgtgcccac cctggtcgtg cagggcggca acgacccgtt
     3661 cggcaggccg gcggagttcc cgcagggcgc ctacgacctg gtcgaggtgc cgtacggcga
     3721 tcacggcttc gccgtgccca agcgcgcgga gatcacccag gaacgggcgc tggagatcct
     3781 caccggcgcg gtacgggagt gggtcgcgtc actcgggtga cccgggaatg ttgtccggcg
     3841 gaccgctgtt gagggcgtca gaagtgctga aggcctcggc accgacgtcg taggagagga
     3901 agtccgccgc atgggttcga ccatctgccc gcccgtcgcc caccaccgcc cttccggcga
     3961 cgcgctgcgc gcggcctctc ccgattcccg cagcagccgc gccgacctgg actggacggt
     4021 gctgcacgcg gccaagaccg ctcctattcg agcggcggca ggcacgggtc gtgttctatc
     4081 ctccgaaacg agtgggaccg gtttcggtcc cgcccaggat cttgaggagg tgggtccggt
     4141 cactgggacc gacgcaggga ccgacaacgg ccaggcggag ctgcccgagg gccagggcgc
     4201 cagcgcggac gcgtccgggg agacgaccgc ggagcgcagc gcgcgcttcg agcgggacgc
     4261 gctcgaattc ctcgaccaga tgtactcggc cgcgctgcgc atgacgcgca acccggccga
     4321 cgccgaggac ctggtgcagg agacctacgc caaggcgtac gcgtccttcc accagttccg
     4381 cgagggcacc aacctcaagg cgtggctgta ccgcatcctc accaacacct tcatcaactc
     4441 ctaccgcaag aagcagcgcg agccgcagcg ctccgccgcg gaggagatcg aggactggca
     4501 gctcgcccgc gccgagtcgc acatgtcgac gggtctgcgc tccgccgagt cgcaggcgct
     4561 cgaccacctg cccgactcgg acgtgaagga agcactgcag gcgatccccg aggagttccg
     4621 catcgccgtc tacctcgcgg acgtcgaggg ctttgcctac aaggagatcg cggacatcat
     4681 ggggacaccc atcggtacgg tgatgtcccg gctgcaccgg ggccgccgcc agctgcgcgg
     4741 catgctggag gactacgccc gtgagcgcgg gctggtcccg gccggcgccg gagagtcgaa
     4801 cgaagcgaaa ggctcgggct catgagctgc ggagagccgc acgagacgga ctgcagtgag
     4861 gtcctcgacc acctgtacga gttcctcgac agcgagatgc cggacgtcga ccgcgacaag
     4921 ttccagcacc acttcgagga atgctcgccg tgcctggaga agtacggcct ggaacaggcc
     4981 gtgaagaagc tggtgaagcg gtgctgcggg catgacgacg tgcccgccga cctgcgggcc
     5041 aaggtcatgg ggcggatcga gctgatccgc tccgggcaga ccgtgccgga gcacgacgtg
     5101 accaaggccc cggcggcacc ccaggagtcc tgaccccgcg ggagcacgcg acgggaccta
     5161 tcacccgaac gtgctaatcc tcaggtcata gaccgcgcac cccccgatcc ccgccctacg
     5221 ctccgagcct gtacaggcgc ggtcggggag ggtcgtgatg gacgcggtac cggcgagggc
     5281 acgcggctat gtggccgccg tcgccgtgcc ggccgtgctc tgcctgctgc ccgcgcccgc
     5341 cgaggacacc tcctggcggg ccctgggcct gctcgccgcg ctctacgcgg cctgcgagca
     5401 cgccgtacgc cgccggttcg gcggcccctt ctaccccgtc ctgctcgccg gcgcgttcct
     5461 gctgcccccc tcggccgccg cgctcgtcgc ggtgcccgcc gccctgctct ccccggtcga
     5521 gcaccggccc gccctgctcc ggcgggtctg gcgggccgcg cagcccgcgc tcgccgtgtg
     5581 ggccgccgcc cgggtgcacg gggcgctcgg cggccgggac gccgtcgccg gctccgactt
     5641 cccgtacgcc ctgctgcccg ccggcgcggc cgtgctcgcc ttctgcacgg tgctcaccgc
     5701 gctcgacggc gggctgcgcg cggcggccgg accggtgccg ccgcggcggg cctggcgcgg
     5761 gctgctggcc cgctccctcg cccccgtcgc ggtgcacgga ctcgccggcc tgatgatggc
     5821 cgtgctgtgg cgcagcccct acggcccggt cgccgccctc ctcgtcctgc tgccgatgtg
     5881 cgtctcctgg tgggtcttcg cccagtacca ccgcgaacgc gcggcccacc aggccaccat
     5941 ccgcgccctc gtgcaggccg tcgacatcaa ggacggctac acccgcggcc acagcgaacg
     6001 cgtcggacag gcctccgtgc tgatcgcccg cgaactcggc atggacgacg agcgcgtgga
     6061 gatgctgcgc ttcgccggca tcctgcacga cgtcggcaaa ctgggcgtcc ccacccggct
     6121 gctgcgcaag aacggcccgc tcacccccga ggagcggcgg atcatcgagc tgcaccccga
     6181 gtacggccac gagatggtcc gcggcatctc cttcctcggt gaggcccgcg ccgccatcct
     6241 ccaccaccac gaacggctcg acggcagcgg ctacccgtac ggcctggccg gggaccgcat
     6301 ccccgagtgc gcccggatcg tcgccgtggc cgacgccttc gacgccatga cctccacccg
     6361 ctgctacagc cgggcccgcc cggtcgaggc cgccgtcgcc gagctggagc gctgcgccgg
     6421 cgcccacttc gacccgcgca tggtcggcgc gctcgtacgc gccctgcgcc gctacggctg
     6481 gcaccccacg gtcaccgccg aggaacccgc ccgcgacacc ccgcccgtgc agcggaccgc
     6541 ccgcaccggg gtgccccgat gaccgtcctg cggctcatcc acagcgccgc cgccctcgtc
     6601 tccgccgcct gcctcacggt caccctgtgg accggcctgc acgaccgggg cgtcgcgctc
     6661 gccttcggcg tgctcgtcac cgccggtgaa ctgacccggt ggagcgacgc cgaggggcga
     6721 cggcaggccg cgccgctcgg cgccgcctgc tccctggcct acgccctgct gggcgccgac
     6781 gacgggcggc ccagccagca cgacgccgcc caggtcgtca ccgtggtcct ggtcgccacc
     6841 gtgctcggtg ccgtcccgca catctggtcc ggccacagcc ccaccgccga ccacctggcc
     6901 cgccgcgtcc tcaccgtcgg cttcgccgcc gtctgcttcc aacccctcta caaccagggt
     6961 gtcttcgccc tctggagcgg ccccgcctac gccctcctgc tgctcaccct gctcgccctc
     7021 acctccctgt gcggcgccgt cctggccgcc gcgctcgccc actgccgcac ccgctggccg
     7081 ttcggcccgc tgctgcgcga ggaactgcgc ggactgctcg gcatcggctc cgccgtctgc
     7141 gcgaccggcg cggtgatggc gctcgccgtc gccgtcgtcg gcctgtgggc gctgcccgtg
     7201 ttctgcctgc ccatgctgct cgtccagctc tccctgcgcc ggtacgcggc cgtccgcgcc
     7261 acctaccggc agaccatcgc ctccctggcc cgcgccaccg agatcgccgg ctgcaccccc
     7321 gccgggcacg cccaccgggt cgccgcgctc agccaggccg tcggccggga cctgggcctg
     7381 accgggccgg aactgaccgt cctggagtac gcggccctga tgcacgacat cggccagctc
     7441 agcctggtcg acccggtccc gggcggcgcc acctccgggc tgcccgccgc ggagcagcgg
     7501 cgcatcgccc tgctcggcgg ggccgtcgtc cggcagaccg gcgtcgatcc ggccgtcgcc
     7561 gtcgtcgtgg agcggcaggc cgacccctac ccggaacagc cgctcgccgc ccggatcgtc
     7621 cgggccgtga acgcctacga ggagaaggcc cgggacgccg gccccgaagg ccccctgcgc
     7681 gcactggagg agctgcggct cggcagcgcc gggagctacg cccccgaggt ggtggagtcg
     7741 ctcgcccggg tactggcccg gccccggggc tggcgcggaa ccgcccccgc accgggcggc
     7801 gggagacgaa cgggactgtc tgaccccgtg cccggctggg taacccatgg gtaatgagcg
     7861 cctttcccgc cgcacgtggt tggatgcgag ggagagggtg tccgggggca caagccagcc
     7921 cactgtgcgg aactggaact ggcaggcggg aatcgtgagg atcttcggca agggacggca
     7981 ccggccctcc gcctcctggc ggcaggccac cgaccgcgcg ttcacactca tcggcgacgg
     8041 ccggtacgag gacgcgggcg agctgctgac acgcgccgcc gatctggaac cctggctgtc
     8101 ggagtcctgg ttcaacctcg ccctgctgca caagttccgg cacgactggg agcaggcccg
     8161 cgcggccgga ctgcgcgcgg tcgccctgct cgaccgggag accggggcgc ccgactggtg
     8221 gaacgtcggc atcgccgcga ccgccctgca ggactggccg ctggcccgcc gcgcctggca
     8281 ggcgtacggg ctgaaggtgc ccgggggcgc ctccgccgcg gagccggtcg gcatggagct
     8341 gggcagcgcg gccgtacggc tctccccgga gggcgaggcc gaggtggtct ggggccgcag
     8401 gctggacccg gcccggctgg aggtgctgtc catcccgctt ccctcgtccg ggcgacgctg
     8461 gggcgaggtc gtgctgcacg acggcgtccc gcacggggaa cgcaccacgt ccaccggcca
     8521 ctcctacccg gtcttcgacg agatcgagct gtgggcgccg tcgcccgtcc ccacctgggt
     8581 ggtcctgctg gaggcggcca ccgaggccga ccgggacgcg ctggagcagc tggccgccga
     8641 cgcggggttc gccgcggagg actggtcgtc ctcggtgcgg ctgctgtgcc ggatgtgcag
     8701 cgagtcccgg atgccgtccg acgagggcga gggggtgcac ctcgacccgc acgaccacag
     8761 tgagcccggt cacccggggc cgctggggca tcgcacggac gggcagctgt gggtgcccga
     8821 gcgggagtgc ggggtggccg cgccggcctc gctggtccgg gggctgctgg acgggtgggt
     8881 cgcggacagt ccggactcgc gggactggcg cgatctggaa gaggtctgct gaccgggcgc
     8941 cgtaccctgt atcagcaaca tctctccccc gtacttcgag gaaggcgtac gtcggtcatg
     9001 gcgcagcagg acaccgatca gcagcacgcg ggcgtgctcc ccgtcgacga cgagggctac
     9061 gtcatcgaca cggaggactg cgaggagcgc gagacggcct ggcgggagcg tggcacctcg
     9121 cggccgatca cggtcgtcgg caacccggtg ctgcacaagg agtgcaagga cgtcaccgag
     9181 ttcggtgagg aactgcagca gctggtcgcc gacatgttcg ccagccagcg caccgccgag
     9241 ggcgtgggcc tggccgccaa ccagatcggt gtcgacctga aggtcttcgt ctacgactgc
     9301 caggacgacg agggcgtccg gcacgtcggc gtggtgtgca acccgaagct ggtcgacctg
     9361 cccgccgagc ggcgccggct ggacgacagc aacgagggct gcctgtccgt ccccacggcg
     9421 tacgcgccgc tcgcgcgtcc cgactacgcc gaggtgaccg gccaggacga gcggggcaac
     9481 ccgatcaagg tgcggggcac cgggtacttc gcacgctgtt tgcagcacga gacggaccac
     9541 ctctacggct acctgtacat cgaccggctg tcgaagcggg accgcaagga cgccctgcgg
     9601 cagatggccg agaacgagcc gcgctacccc gtggtcgcca acgactgacc ggcgctgcgg
     9661 acttcggggc gccccggccg gggtccttcc tggccggggc gccttcgtgt caccgctgtt
     9721 cgtgcgcgcg gccgtcgtac aaccgatccc ttctgccctc ctagtgatcc ttaaccagtc
     9781 acgcaagggg ggattctcgg caccttgggg tagtgagtgg agcaaatccg ttcccacggc
     9841 ggtcagttgt ggtgctgaat ggaagtgcgg gatacgcaac ggcgcacgcc cggcacaacg
     9901 ggaggggtgt gcgctcctgg cggctgagag gggtttgttc gtgcaagctt tcccacgcag
     9961 caccacagcg acgccgacgg cgctcgtagt accaccctca ctggcactcc cggtgatcga
    10021 gtccgccttt ccccggcaac tgcatccgta ttggccacga ctccaggaga agacccgctg
    10081 ctggctcctg gaaaaacggc tcatgccggc ggacaaggtg cgggaatatg ccgatggact
    10141 gtgctacacg gacctcatgg cgggctacta caccggcgcc cccgacgagg tcctgcaggc
    10201 catagccgac tacagcgcct ggttcttcgt ctgggacgac cgccacgacc gcgacatcgt
    10261 gcacggccgg gcgggcgact ggcggcggct gcggtaccgc ctgcacacgg ctctcgacgc
    10321 acccagacac cacctgcacc accccgaccc gttggtggcg ggcttcgcgg acagcgtgct
    10381 gcggctgtac ggcttcctgc cggccacctg gaaccagcgg ttcgcccggc acttccacgc
    10441 ggtgatcgag gcctacgacc gtgaattccg caaccgcacc gagggataca tacccggcgt
    10501 cgatgagtac ctcgccctgc gccgtctcac cttcgcccac tgcatatgga cggacctgct
    10561 ggaacccagt gccggatgtg aactgccgga ccacgtacgg aaaaacccgg cctaccgccg
    10621 ggcggcgctg ctcagccagg aattcgccgc ctggtacaac gacctctgct cgctgccgaa
    10681 ggaaatcgcg ggcgacgagg tgcacaatct cggaatcagc ctcatcaccc atggggggct
    10741 gaccctcgaa gaagcggtgg acgaaatcag gcggcgcgtc gaggaatgca tcagcgaatt
    10801 cctcgacgcc gagcagaaag ccctcgggtt cgcccgcagc ctcgacgacg gaacggtccg
    10861 cggcgcggaa ctgagcgccg ccgtccactc ctgcgtcggc aacatgcgca actggttcag
    10921 ctccgtctac tggttccacc acgagtccgg ccggtacatg gtcgacagct gggacgaccg
    10981 gtccacgccc ccgtacgtca cgaacgaagc ggcaggtgag aaatgaccgt cgagtcggtg
    11041 aagccccaca cccccggaac cccgggggcc cccgcggcat ccgcactgcg cgaaccaccg
    11101 ctggccggag gcgccgtacc ggtcctcggc cacggcctga gactggtccg cgacccgctc
    11161 gccttcatgt ccgggctgcg cgagcacgga gacgtcgtac gcctgaggct cggccccaag
    11221 acggtgtacg ccgtcaccac gccggcgctc accggagcac tggccctcag ccccgacttc
    11281 aagatcgacg gcccgctgtg ggagtccctc gaaggcctgc tcggcaagga gggcgtggcc
    11341 accgcgaacg gcccccggca ccgccggcag cggcgcacca tacagcccgc gttccggctc
    11401 gacgcgatac cgggctacgg cccggtcatg gaggaggagg cgcacgcgct gaccgagcgc
    11461 tggcggcccg gcgagaccat cgactgcacc tccgagtcct tccgggtcgc cgtccgcatc
    11521 gccgcccgct gcctgctgcg cggcgactac atggacgagc gcgcggagcg gctcagcgtc
    11581 gacctcgcca ccgtcttccg tggtatgtac cgcaggatgg tgatcccgct cggaccgctc
    11641 taccggctgc cgttcccggc caaccgcgaa ttcaaccggg cattggccga tttgcatctg
    11701 ctggtggacg agatcgtcgc cgagcggagg gcatctggtc aaaagccgaa cgatttgctg
    11761 acggcattgc tggaggcgaa ggacgacaat ggcgacccca tcggggaaca ggagatccac
    11821 gaccaggtcg tcgcgatact cacccccggc agcgaaacag tcgcgtccac gatcatgtgg
    11881 ctgctgcagg tgctcgccga acatccggaa cacgcggaga aggtacggac cgaggtcgaa
    11941 tcggtgacgg gcggccgacc ggtcggattc gagcacgtcc gctcactcac gcacaccaac
    12001 aatgtggtcg tcgaggccat gcggctcagg cccgccgtat ggatattgac gcggcgcgcg
    12061 gtgaccgaca cgtcactcgg ggactatcgc attccggccg gggcggacat cgtctacagc
    12121 ccgtacgcca tccagcgcga cggccgctcc tacgcccgcc acctcgactt cgaccccgac
    12181 cgctggctgc ccgaacgggc caaggaggta ccgaagtacg ccatgagccc gttcagcgtg
    12241 ggcaaccgca agtgccccag tgaccacttc tccatgaccc agctcagcct gatcaccgcg
    12301 gcgatctcgg cgaagtaccg cttcgagcag gtcggcgggt ccgacgacac cacccgtgtg
    12361 ggcatcacgc tgcgcccaca gaacctgctg ctacgggcga tgccctggta ggcccggcgc
    12421 cggcgcgcgt tcaggcggcc tgcgggcccc ggaacgcgcg ccggtaggcg tgcggggtcg
    12481 tccccagcgc ccggacgaac tgatgccgca gcgcggcggc cgtaccgaac ccggtgcgcc
    12541 aggcgatggc gtccatggtc tcgtccgtgc cctccagcaa ctcctgcgcc agcagcacgc
    12601 gttgacgcag aatccaccgg tagggcgtgg tccccgtctc ctgctggaag cgccgggcga
    12661 aggtgcgcgg cgccatgtgg gcgcgggcgg cgagctgctc gaccgtgacc tcctggtcga
    12721 ggtgagcctc catccacgcc agcacctccc cgaccgtgtc gcagggtgcc ttcggcagag
    12781 gccgctcgat gaactgcgcc tgcccgccgt cccggtgcgg cggcaccacc atccggcggg
    12841 cgatcttgtt ggccacctcc ggaccctgct ccttgcgcac caggtgcaga caggcgtcga
    12901 tcccggcggc ggtgccggcg gaggtgatca ccgggtcctc gtccacgtac agcacgtccg
    12961 gctcgaccgt gagccgggga tagcgccggg cgagctgctc ggcgtggtgc cagtgcaccg
    13021 cacaccgccg cccgtccagc agccccgccg cggccagcac gaacaccccg gagcagacgc
    13081 tgagcacccg cgtgccccgg tccacggccc gccgcagcgc cgccagcagc tcctcgggat
    13141 actcccgctg cgcataggtc tcaccggccg gtacggcgat cagatcggcc tcgtccagcc
    13201 ggtccaggcc gtacggcgtg gacacggtga acccgcagtg ggtgcccagc tcgggcccct
    13261 ccgccgacac cacggcgaag tcgtacaccg gcagcccgtc gtcgctgcgg tcgatgccga
    13321 acacctcgca cacgacaccc agctcgaagg gatgcacccc gtccagcagc acggcggcca
    13381 cgttcttcag catgctgcca gtgtgcctcg ccagtggcag taattcgagg gtctacggca
    13441 gtgctgccac tcccggtaag gagtctccgg gacgacagtg gtgtccatga acggaaacca
    13501 gatcgaaggc ctgatcggaa tgctcacgac cctcgggatc ctgatcctcc tggtcctccc
    13561 ctccgtgctc ggcgtcctgc gcgacaggcg catcgaccgg cagatcaggg aggcccagga
    13621 ggcccgcgga gagaggaagg atcagaagtc ctcgtccagg tcgacggtgc cttccacggc
    13681 gacctggtac gccgacgggc ggcgctcgaa gaagttcgtc agttcctgaa cgccctggag
    13741 ctccatgaag gagaaggggt tctcgctccc gtggacgggg gcgaagccga ggcgggtgag
    13801 gcgctggtcg gcgacgcatt cgaggtactg gcgcatggag tcggtgttca tgccgggcag
    13861 tccgtcgccg cacaggtcgc gggcgaattg gagttccgct tcgacggctt cgcggagcat
    13921 gtcggtgacc tgctgctgga gctggtcgtc gaagaggtcg ggttcttcct tgcggacggt
    13981 gtcgacgacg tcgaaggcga agctcatgtg catggtctcg tcgcggaaga cccagttggt
    14041 gccggtggcg aggccgtgca ggaggccgcg gctgcggaac cagtagacgt aggcgaaggc
    14101 gccgtagaag aagagtcctt cgatgcaggc ggcgaagcag atgaggttga gcaggaagcg
    14161 gcggcggtcc gccttggtct ccaggcggtc gatcttctcg acctcgttga tccacttgaa
    14221 gcagaactcg gccttctcgc ggatggaggg gatgttctcc acggcggcga aggcggcggc
    14281 gcggtcgtcg gggtcgggga ggtaggtgtc caggagggtc aggtagaact ggacgtggac
    14341 ggcttcctcg aacagctgcc ggctgaggta gaggcgggct tcgggggagt tgatgtgctt
    14401 gtagagggtg agcacgaggt tgttggcgac gatggagtcg ccggtggcga agaaggcgac
    14461 cagccggccg atgaggtgct gttcttcggg ggtgagtttg gcgaggtcgg cgacgtcgga
    14521 gtggaggtcg acctcctcga cggtccaggt gttcttgatg gcgtcccggt agcgctcgta
    14581 gaagtcgggg tagcgcatcg ggcggagagt caactcgaag ccggggtcga gcaggttctg
    14641 gggtcgggtg gtcattactg gcaggcctcg caggactcgg ggttttccag ggagcaggcg
    14701 atcgcgtcgg ggtcgacggc ctgctgtacg gggatgggct tggcggcctg cgcctggccc
    14761 tgggcggcgc gggcgatgcg ggtcgcgggg cgcgagcgca ggtagtacgt cgtcttgagc
    14821 ccggacttcc aggcgtaggc gtacatcgag gagagcttgc cgatggtcgg cgtctccatg
    14881 aacaggttca gcgactggga ctggtcgagg aacggggtgc gggcggcggc catgtcgatc
    14941 aggccgcgct gggggatctc ccaggccgtg cggtagagcg cgcggatctc ctcggggatc
    15001 cagaggaagt cctggacgga gccgttggag tcgcgcagcg cctcgcgggt gcgggcgtcc
    15061 cagacaccga ggtccttgag gtcctggacc aggtaggagt tgacctggag gaactcaccg
    15121 gacagggtct cgcgcttgaa caggttggag acctgcggct cgatgcactc gtacacgccc
    15181 gcgatggacg cgatggtggc cgtcggtgcg atcgcgagga gcagcgagtt gcgcatgccc
    15241 gtctccgcga cgcgcttgcg gagggcgtcc cagcgctcgg gccacgtcag gtcgacgtcg
    15301 tagtggtcgg ggtggaggac gccgcgggcg gcgcgggtct gctcccaggc gggcagcggg
    15361 ccgttgcgct cggcgaggtc ggcggaggcc tcgtaggcgg ccagcatgat ccgctcggcg
    15421 atccgcgtgg acagggcctt ggcctcgggg gagtcgaagg gcaggcgcag cttgaagaac
    15481 acgtcctgca gacccatcgc acccaggccg accgggcgcc acttggcgtt ggaacggccc
    15541 gcctgctcgg tggggtagaa gttgatgtcc accacgcggt cgaggaaggt cacggcggtg
    15601 cggacggtct cgtccagccg ctcccagtcg atgccgccgt cctggacgaa cgcgccgagg
    15661 ttgaccgagc ccaggttgca gaccgcggtc tcgccgtcgt tggtgacctc caggatctcg
    15721 gtgcagaggt tggaggagtg gacgacgttg ccgggctcgg cggtctggtt cgcggtccgg
    15781 ttggcggcgt ccttgaacgt catccagccg ttgccggtct gcgccagggt gcgcatcatc
    15841 cggccgtaca actcccgcgc gggaatggtc ttcttggcca ggccggcggc ctcggccttc
    15901 cggtaggcgg cgtcgaactc ctcgccccac aggtcgacca gctcgggcac gtcggcgggg
    15961 gagaacagcg accactgccc gtcggcgttg acccgccgca tgaactcgtc cgggatccag
    16021 tgcgccaggt tcaggttgtg ggtacgccgg gcgtcctcac cggtgttgtc ccgcagctcc
    16081 aggaactcct cgatgtcgga gtgccaggtc tccaggtaca ccgccgccgc gcccttgcgc
    16141 cggccgccct ggttcacggc ggccacggac gcgtccaggg tcttcaggaa cggcacgatc
    16201 ccgttggagt gcccgttcgt cccccggatc agcgaaccgc gcgaccggat acgggagtac
    16261 gacaggccga tgccgccggc gtgcttcgac agccgggcga cctggtggta acggtcgtag
    16321 atggagtcca gctcgtccag cggggagtcc agcaggtagc aggacgacat ctgggggtgc
    16381 cgcgtaccgg agttgaacag ggtgggggag gagggcaggt agtccaggcg gctcatcagg
    16441 ccgtacaggg acgccacttc gtccacggaa cgggccgtgt cgtcctcggc gaggccgctc
    16501 gccacgcgca gcatgaagtg ctggggcgtc tcgatcacct tgcgggtgat cgggtggcgc
    16561 agcaggtaac ggctgtagag ggtgcgcagg ccgaagtagc cgaagcggtc gtcggccgcg
    16621 gcgtcgatca gcgcgtcgag ccgtgcggcg tgcaggcgcg cgaactcggc ggtgcggtcg
    16681 gcgatgaggc cctcgcggtg cccgaccgcg acggactcgg tgaaggacgt cacgccctgc
    16741 gaggcggcct cgtcccggat ggtgagggtg agcagccggg cggccagctt cgagtacgcg
    16801 gggtcctcgg cgatcaggcc ggcggcggcc tccgtggcca gctcccgcag ttccgcctcg
    16861 tcggcccgcg cggaccggcc gcgcagcgcg gcggcggcca cccggcccgg gtcggcgtcg
    16921 ggcaggtcgg cggtcagctc ggtcagggtc cgcagcagcg cggtaccggg accgtcggtc
    16981 tccagctcgc tgactgaagc cggatcggct ggcgcgatgg tcacgtgggg ctctccctcg
    17041 ctcggcacgg ggcctggcgg agggcagggg gcagctacga gcgcgcacgg cgtcgcgtcc
    17101 acctgcccac tccgcgaggc ccggacgttc tgaaccaccc ggaccggacg ttccgggtgc
    17161 gctgtcggca ggtcgtcgga ctcaacaggc gcgcggacgc acgcaggtac accgttgcgg
    17221 gacagttccg gactcgcacc ggattcccct gcggcgacag cgagcacgag catacatcta
    17281 gtgccgggtt gtcgtggcac ccccagatgt tgtgccggtc tggtgtcaga gggtcaactc
    17341 gtcagcgagc ggagtgatgt cccgccgctg cggaagcggc gtccggcccg gctcggggat
    17401 gcgcacggga ccggggcgct cgcggacgcg gtgggcggcg cgcacggcgc gctgggcgga
    17461 agtccggggc accggggccg ccggacgggt acgacaacgg gccgccgatg atcctgctct
    17521 cggcggcccg ctgcggggcg tcaggggtgc ccgcgtggtt cagtgaccgg cgcccgcggt
    17581 cgcgggcggc agctccacct cgaccccggg gtcaccggcg tcggccgtgt agtcctccgg
    17641 cttggtctcg tcgaggccct caggggcctt cagagccttc agcacgacgg tcaggaccac
    17701 ggtcaccaga acgttcagga cgaacgccgt caggccgatg tagccgatct cgccgatgcc
    17761 ggggatctcc ttggcgttgc cgccgaagtg cttctgggtg ggcgaggcga tgccgtaggc
    17821 ggcggcggtg ccgtagacca tgcccacggc ccagccggcg agcagcgccc agcggtggaa
    17881 ccagcgggtg aacaggccgc cgaccagggc cgggaaggtc tgcaggatcc agatgccgcc
    17941 cagcagctgg aagttgatgg cgacggtctt gtccatggtg aggacgaaga ccagggcgcc
    18001 gaccttcacc agcagggaga ccagcttgga gacccgggtc tcctgctcgg ccgtggcgtc
    18061 gggcttgagg aagtccttgt agatgttgcg ggtgaagaga ttggccgccg cgatggacat
    18121 gatcgcggcc gggaccaggg cgccgatccc gatggcggcg aaggcgacgc ccgcgaacca
    18181 gtccgggaac atgtcctcga acagctgcgg gatggccagc tggccgttgg tgaccttcac
    18241 cccggccgcg atcgccatga agcccagcag cgccagcaga cccagcatca gggagtacag
    18301 cggcaggatc gtggtgttgc ggcggatcac ctcacggctc ttggacgaca gggtcgcggt
    18361 gatcgagtgc gggtacatga acagcgccag cgcggagccg agcgccagcg tggcgtacgt
    18421 ccactggccc gcctccggcg gcgctatcgc cccacgcggc ttctcggtga ccgggttgac
    18481 ctggttgaac gcctcgcccg ccttggcgaa gatgtcgtcg aacccgccca gcttgatcgg
    18541 gatgtagatg atcgccaccg cgatgacgat gtagatcagc gtgtccttga cgaacgcgat
    18601 cagcgcgggg gcgcgcaggc cggaggagta ggtgtaggcg gccagcacac cgaaggcgat
    18661 cagcagcggc aggtccttca cgaaccagtt ggtgtcctcc ccgccgccga cgcccatcac
    18721 gtccagcacc gcctggatgc cgacgagctg gagcgcgatg tacggcatgg tcgccaggat
    18781 gccggtgacc gcgaccgcga gcgacagccc cttcgagccg aaccggccgc gcacgaagtc
    18841 ggaggtggtg acgtacccgt ggcggtgcga gaccgaccac aggcggggca ggaaggtgaa
    18901 gatcagcggg tacaccagga tcgtgtacgg caccgcgaag aagccggccg cgcccgccgc
    18961 gtagatcgcc gcgggtacgg cgacgaaggt gtacgccgtg tacaggtcgc cgccgagcag
    19021 gaaccaggtg atccaggtac cgaaggaccg cccgcccagg ccccattcgt ccagggagtg
    19081 ctcgttctcg gccctgcgcc agcgcgcggc caggaagccc atgaccgtga cggccaggaa
    19141 gaagaagatg aagacgccga gcgcgacgcc gttgacgccg tcgttcactt cgccgcaccc
    19201 ccgttcgcgc ccttgcggcc gcgctggtca cgttgccaca gcttgtacgc gatcatcgtg
    19261 agcacggtcg agatcagcac ccagagcatc tggtaccagt agaagaacgg gatcccgatg
    19321 aacgtggggt ccgtcttggc gtacgagccg acccacagca tcgccacgaa gggcgcgacg
    19381 agacacaagg cgatgatcac ccggaccggc gtcaccaccg gtggtctcac ttcaggcgtt
    19441 tcggacatgc cacggctccg tcccctcgct gatcacctgt gtaatgagca ggcaatctag
    19501 gtgacgccgt cgcgacagcg gaagacctcg tccgcatatc ggtatatcga ttcagcgaac
    19561 gtgcggggca gttactccgc gggccgcttc aaccgggcca cgaacttgta ccggtctccg
    19621 cggtacaccg agcggaccca ctccaccggc ttgccctcgc ggtccagcga gtggcgggag
    19681 agcatcagca tcggcaggcc cacgtccgtg ccgagcaggc ccgcctcgcg cggggtggcc
    19741 agggaggtct cgatggtctc ctcggcctcg gcgaggtgga cgtcgtagac ctcggccagc
    19801 gcggtgtaca gcgaggtgta cttcaccagg gagcgcctga gggccgggaa gcgcttggcc
    19861 gacaggtggg tggtctcgat cgccatcggc tcgccgttgg ccatgcgcag ccgctcgatg
    19921 cgcagcacac gcccgccggc ggcgatgtcg agcagctcgg cgagccgctc gtcggcggtg
    19981 atgtacccga tgtccagcag ctgcgaggtc ggctccaggc cctgggcgcg catgtcctcg
    20041 gtgtaggagg tgagctgcag ggcctgggag accttgggct tggccacgaa ggtgcccttg
    20101 ccctggatgc gttccagccg gccctccaca accagttcct gcagggcctg gcggaccgtg
    20161 gtgcgggagg tgtcgaactc ggcggccagc gtgcgctcgg gcgggaccgg cgtgcccggt
    20221 gcctgggtct ccgtcatgtc gagcaggtgc ttcttcaagc ggtagtactt gggcacgcgc
    20281 gcggtacggg tggtgcctgc ctcgttctcc gcactgctga cgtcggtgct catgctctgc
    20341 cttcccggct ccggatgccg aaagcgaccg acatccccat cggccacggc tcacatcgtg
    20401 gcacgggttg tcgtgtcagc actccacccg cacgctccgt gatctcctct atataccgtt
    20461 gcacccgctg ttggtctagt ccatcgaggg agtgactccg gaagcggccc gtcaccggca
    20521 cgcgtcgccc gggtccgctt ccggcgccgc cgccaccggc tagatcccct gccactccgg
    20581 cttgttggcg taggtgtggc ggaagtagtc ggccagcttg agcttggacg cggcggcctc
    20641 gtcgacgacc accgtggcgt gcgggtggag ctggagcgcg gaggccgggc agatcgcggc
    20701 gaccgggccc tcgacggtcg cggcgaccgc gtccgccttg ccgtcgcccg tggccagcag
    20761 caccaggtgc cgggcctcca ggatggtgcc gatgccctgg gtgatgacgt ggtgcggcac
    20821 ctgctcgatg tcgccgtcga agaagcgggc gttgtcgatc cgggtctgct cggtcagcgt
    20881 cttgatccgg gtgcgcgagg cgagcgagga gcacggctcg ttgaacccga tgtgcccgtc
    20941 ggtcccgatg ccgagcagct ggaggtccac cccgccggcc tcggcgagcg cgcggtcgta
    21001 cgcctcgcac gccgcctgga cgtcgt
//
