LOCUS       NZ_AP024135            25142 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1148268
            Orig. end                         :: 1173410
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="9"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25142
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15142](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(212..227)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            complement(462..1550)
                     /locus_tag="K6K39_RS04745"
                     /old_locus_tag="EASAB2608_01002"
     CDS             complement(462..1550)
                     /NRPS_PKS="Domain: PKS_ER (118-283). E-value: 4.4e-09.
                     Score: 27.8. Matches aSDomain:
                     nrpspksdomains_K6K39_RS04745_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677444.1"
                     /locus_tag="K6K39_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01002"
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_221334020.1"
                     /sec_met_domain="ADH_N (E-value: 2e-08, bitscore: 33.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.3e-08, bitscore:
                     32.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAVLTRFGAPLAVREVPDPEAGGGEVVVEVLAANVAPYAAEVF
                     SGKRKYPLVPPVVPGVGAVGRILHVGPDATRLQAGDLVWCDSTVRSRDDALTPDITLQG
                     WSSRGEGGARLAEYLHDGAFAELMRVPTENVYPLPAAAGEDPARWAALTVHTISYGGLL
                     AGGLAAGETLLVSGATGNLGSSAVAVAFAMGAGRVVAPGRNKEVLDLLADRFGPRLRPV
                     PLTGDEATDRAAMSAAADGPIDMVIDLLPPRAPSSASRAAAMTVREYGRVVLMGGVGML
                     GGGDLALPYPWIMRNSVTVRGQWMYPRTANVGIIRLLASGTLDLAPERVRSFGLDAVND
                     AITYATAHGGPFDRTSLTPSAG"
     aSDomain        complement(702..1196)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS04745_PKS_ER.1"
                     /evalue="4.40E-09"
                     /label="K6K39_RS04745_PKS_ER.1"
                     /locus_tag="K6K39_RS04745"
                     /protein_end="283"
                     /protein_start="118"
                     /score="27.8"
                     /tool="antismash"
                     /translation="LHDGAFAELMRVPTENVYPLPAAAGEDPARWAALTVHTISYGGLL
                     AGGLAAGETLLVSGATGNLGSSAVAVAFAMGAGRVVAPGRNKEVLDLLADRFGPRLRPV
                     PLTGDEATDRAAMSAAADGPIDMVIDLLPPRAPSSASRAAAMTVREYGRVVLMGGVGML
                     GG"
     CDS_motif       complement(939..1037)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS04745_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS04745"
                     /protein_end="204"
                     /protein_start="171"
                     /score="10.8"
                     /tool="antismash"
                     /translation="TLLVSGATGNLGSSAVAVAFAMGAGRVVAPGRN"
     gene            1653..2546
                     /locus_tag="K6K39_RS04750"
                     /old_locus_tag="EASAB2608_01003"
     CDS             1653..2546
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719584.1"
                     /locus_tag="K6K39_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01003"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_221334021.1"
                     /transl_table=11
                     /translation="MDISSTGLRVLRQIAESGSFTAAAARLGYTQSAVSRQAAALERSV
                     GTTLFERRPDGVRLTPAGLTLLRHAHTVLASLAAAERELTGTVPRTEPVRLGAVLSAGS
                     AILPAALAHLAAADPQITVTTREGTTPTLIRALRAGSLDLAVLTSRPPHRPFDGDSPRL
                     HLETVADTELVVAVPSTGEFAGRTTVHVEELVDAAWIATPSSGGEPLLGVWPGLPGRPR
                     IIHSARDWLTKLQLVAGGFGVTTVPFPLSPVLPPGVSLLRVDGAPREIRRVLVARLGGH
                     PTPAITTVTRAITATV"
     gene            complement(3512..3784)
                     /locus_tag="K6K39_RS04755"
                     /old_locus_tag="EASAB2608_01004"
     CDS             complement(3512..3784)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_01004"
                     /product="hypothetical protein"
                     /protein_id="WP_221334022.1"
                     /transl_table=11
                     /translation="MAVLDADEWDEKLKQLAGRTEADPAVVREGVRRLNAGLLTTRDMR
                     LVLLSTGHLTGWQPPRRAVTRTVIHQASRSTSPVGASGITRAAIR"
     gene            <4085..>4299
                     /locus_tag="K6K39_RS04760"
                     /pseudo=""
     CDS             4085..>4299
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558197.1"
                     /locus_tag="K6K39_RS04760"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPMNRPDRVMADKR"
     misc_feature    4286..4288
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<4319..>4699)
                     /locus_tag="K6K39_RS04765"
                     /old_locus_tag="EASAB2608_01005"
                     /pseudo=""
     CDS             complement(<4319..4699)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="K6K39_RS04765"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="EASAB2608_01005"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRSRGGLTTKIHLVADSRSRPLAFVITPGQAGDAPAFPHVTARL
                     RVSRPVGRPRTTPEIVLADKAYSSRAIRDQLRRRGIRAVIPLLADQAANRRWLGRLGGR
                     PPTFDREAYKQRDTVERCINKLK"
     gene            complement(<4810..>5052)
                     /locus_tag="K6K39_RS04770"
                     /pseudo=""
     CDS             complement(<4810..5052)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019074425.1"
                     /locus_tag="K6K39_RS04770"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="Ku protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFVPLESVDPLKIAEGYYLQPAGQVAAKPYKLLVKALSRSAKVAV
                     AKYVCSGWERLGLLRVHDDVLLHAMRWPDEIRAPTE"
     gene            5160..5495
                     /gene="cutA"
                     /locus_tag="K6K39_RS04775"
                     /old_locus_tag="EASAB2608_01007"
     CDS             5160..5495
                     /GO_process="GO:0010038 - response to metal ion [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cutA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267966.1"
                     /locus_tag="K6K39_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01007"
                     /product="divalent-cation tolerance protein CutA"
                     /protein_id="WP_221334024.1"
                     /transl_table=11
                     /translation="MASDIVIAQTTIDDEEQAKALARGAVESRLAACAHIDQPFAATYW
                     WRGTIETAQEWRISYKTTTERLPELEAWVAEQHSYEVPEWITLPVTGGSEAYLKWVVDE
                     TSPHSAE"
     gene            complement(5500..6744)
                     /locus_tag="K6K39_RS04780"
                     /old_locus_tag="EASAB2608_01008"
     CDS             complement(5500..6744)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327522.1"
                     /locus_tag="K6K39_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01008"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_221334025.1"
                     /transl_table=11
                     /translation="MATDQFAELLVRLRKDAGRTQEEQAAAINAVSGRDTMTRREINRY
                     EHGQNIPTNHTLAHIAVACGLSPEHLQREAAAARARRRKGARPEGEDQDDVKRRTLLGG
                     AAVGAAAATEPWERLAHALSRGKEIDSKAAGSLVNRACELHVRESHLTARELQSEVESH
                     LDAITAALPRAGENERALTIAAGETAALAGWVAWDLGDEPRAHAFYKVTMDCAKNIGHP
                     PLRALALGYASYGAATPEKAAELLIQATKDVRGQGNAAAAAWLYGRLAEEAASVGDHTN
                     ALRALDRARFAYEFADHTAEQAWVRFVTPYRMDSLALSVYGQLGRQELAETADQAVDRL
                     GRELPESGVVVLGDLANALLRGGDVDQGVYVSRQFAAASDARPTTMGRARAQAVAAQLP
                     ASERELARHLRQFAA"
     misc_feature    complement(6547..6549)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6874..7149
                     /locus_tag="K6K39_RS04785"
                     /old_locus_tag="EASAB2608_01009"
     CDS             6874..7149
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_01009"
                     /product="hypothetical protein"
                     /protein_id="WP_221334026.1"
                     /transl_table=11
                     /translation="MTTIRKVLVAGRPLPAHQAANAPPTPAQWIALPLDSVRTVQRRGE
                     LDGCRDSWWGLTETPAVTTCRQARLSSDHFSVVAHVRTRAVLGICL"
     gene            7180..7617
                     /locus_tag="K6K39_RS04790"
                     /old_locus_tag="EASAB2608_01010"
     CDS             7180..7617
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.4"
                     /locus_tag="K6K39_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01010"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_221334027.1"
                     /transl_table=11
                     /translation="MSPSASAPPLKTRVPDRTGKKVKGIRDWTPPHQREEMERLLERLR
                     AGLPVDAAYDDLNEVLGDGPALTDERIEELTERFRGSLMVLVDQVRERAPGDAQEREAL
                     VEKARMLRQENATGSPLGFLRRLAFSAEALLDLLLDEEPAS"
     gene            7626..8027
                     /locus_tag="K6K39_RS41920"
                     /old_locus_tag="EASAB2608_01011"
     CDS             7626..8027
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040050.4"
                     /locus_tag="K6K39_RS41920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01011"
                     /product="DUF6302 family protein"
                     /protein_id="WP_399010720.1"
                     /transl_table=11
                     /translation="MQQVQCGVDVLPAGEAYDYDYFRVRLGDDQLLKRSVALRVYRMPF
                     LAVPIGRTRRGGFFPLYDLAAASAVCAALEPLNGFPGLRTAWVAAPVAAHAVEWGDRPP
                     LRWDTEGQRLAFYGFTQPGPRPAPVPLSG"
     gene            8107..8289
                     /locus_tag="K6K39_RS04800"
                     /old_locus_tag="EASAB2608_01012"
     CDS             8107..8289
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140274.1"
                     /locus_tag="K6K39_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01012"
                     /product="DUF5999 family protein"
                     /protein_id="WP_221334029.1"
                     /transl_table=11
                     /translation="MCRHEPPCPTASAADRDAAATVVRHDEQGWALLCNGVLRFDDTGD
                     LLPDGRVIAPHRPAA"
     gene            8440..9672
                     /gene="fxlM"
                     /locus_tag="K6K39_RS04805"
                     /old_locus_tag="EASAB2608_01013"
     CDS             8440..9672
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447322.1"
                     /locus_tag="K6K39_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01013"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_221334030.1"
                     /sec_met_domain="PCMT (E-value: 6.3e-39, bitscore: 132.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTENFQTPHVSEQELRDAMVQCLIDMGTLRTSRAVAAFRTVPRH
                     LAAPGTDMAKAYDVESALITKTDPTGVGISSVSAPRIQAMQIEQADIQLGMNVLEIGSG
                     GVNAAYLAEMVGDQGRVVTVDIDPDVTARARDFLKTTGHRNVTVITGDGGSGALDYSPF
                     DRIIVTVQAADIPSSWVHQLSEGGRLVVPLRMRGMTRSVAFVRDDQRLTSDGFELCGFV
                     PMQGVGENRMRVVLLHDVEGEEIGLRLDDHPEPDVKALAEALRTPRCEEWSGVTLAGDE
                     SNEHLDLWLATAFDSLPLMAAQPAARERGLVASASPLGIPTLVEGGSFAYRTVRRTDDP
                     NRFELGAYGHGPDGQKTAERLVEAIRTWDREHRGDRAHIDVYPAGTPDEQLPLGARVID
                     RPHSRITISWP"
     gene            9738..9932
                     /locus_tag="K6K39_RS04810"
                     /old_locus_tag="EASAB2608_01014"
     CDS             9738..9932
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="K6K39_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01014"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_221334031.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.2e-12, bitscore:
                     44.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPQNSTVPLKAATDFTGDGGSDFDLRVETVASVAVPGALLNDTG
                     DGCGSTCQSACANSTCIGG"
     CDS_motif       9738..9851
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAPQNSTVPLKAATDFTGDGGSDFDLRVETVASVAVPG"
                     /locus_tag="K6K39_RS04810_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9852..9932
                     /prepeptide="core"
                     /locus_tag="K6K39_RS04810_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-2.50"
                     /molecular_weight="2311.5"
                     /monoisotopic_mass="2310.0"
                     /core_sequence="ALLNDTGDGCGSTCQSACANSTCIGG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPQNSTVPLKAATDFTGDGGSDFDLRVETVASVAVPG"
                     /leader_location="[9737:9851](+)"
                     /alternative_weights="2329.5"
                     /alternative_weights="2347.5"
     gene            10001..13036
                     /locus_tag="K6K39_RS04815"
                     /old_locus_tag="EASAB2608_01015"
     CDS             10001..13036
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="K6K39_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01015"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_260335041.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-183,
                     bitscore: 608.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.4e-22,
                     bitscore: 76.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-29, bitscore:
                     102.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHAVDAGMIRTSAFPLSATLPPWPDLDGGSATDVSLWKEWITQV
                     WADDTRAAAVEVASPLLADSIRQALDDERTRPRAIRRTVISLARYLLRMQYRATPSGLL
                     AGPAPLRIGPTAQAIWGTAHRAFARADSQWLHDVVATLERDPQVLRYLPVVVNPTCTVR
                     GGRVTVLHQPGADGPTDTRMRRTPAIEAVLTLARSEITVGDLADKLSSEYPDTDIAVIE
                     NMLRDLVAHRVLLSTLHAPMTCENALGHLIDRLEVADVASAPTRELRQISTLLAWHDTA
                     PVEEQRSLRGRTTAKMIALTAIADRTLAVYLRPDCDIVLPEAVTCEAEKALEVMARVTP
                     FPSGSPAWKDYRTRFLERYSMGAIVPLRDLIDPDTGLGYPVSYRGTLLKRPVLATTWRD
                     EHLLALAQNAALNDQREVVLTPEDIAALSLGEPDQVPAHVELCFSVLSPSLEDLNRGDF
                     VLSTVGLATGAGTTTGRFLSMLERPDRERMIAAYAGLPTLTVGAERGQVSSPPLRVQTY
                     NVGRAPAIVPNVLAVGEHNLDASLKVDDLGVVADSQRLYLVSLSTGEPIEPSVMNAVEL
                     SNATHPLARFVCELHRSHTAVLVPFSWGAAAQLPFLPEVRIGRTILSSACWRLRTRDLN
                     GGGLWSWRFTNWRVRYGVPRTVYLGADDRRLRLDLDVPAHVQLLRADLERYGMIVLHEA
                     PPEEAFGWVGRAHEVTIPFAAEQAAASPPAFRPEAVVNRDLGRLPGGSRWAYLKLYGNP
                     DRADEVLTPHLPRLLLEFGAEAPDVWFSRYADPDSHLRVRLRLSSPEAFGEAVQKTAVW
                     ADELRREGLIQRVQWDTDTPEIGRYGTGPVLEAAERYFTADSAAVVAQLVLPIPGHCKP
                     AVTAASMVDIATVFLGSPQAGRAWLTMNFRNSEGAASSRDAQALAILLTGADVGERAAA
                     LRQLPRGQHVAGTWALRRRLLDEYRQALQTADIDPATVLPSLLHMHHNRAAGIDPDAEA
                     TCRRLARTAALSWTARAEGAPR"
     aSDomain        10460..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K6K39_RS04815_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.20E-24"
                     /identifier="RREFam001.1"
                     /label="K6K39_RS04815"
                     /locus_tag="K6K39_RS04815"
                     /protein_end="241"
                     /protein_start="153"
                     /score="76.9"
                     /tool="antismash"
                     /translation="VVVNPTCTVRGGRVTVLHQPGADGPTDTRMRRTPAIEAVLTLARS
                     EITVGDLADKLSSEYPDTDIAVIENMLRDLVAHRVLLSTLHAP"
     misc_feature    12203..12205
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13033..14175
                     /locus_tag="K6K39_RS04820"
                     /old_locus_tag="EASAB2608_01016"
     CDS             13033..14175
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319710.1"
                     /locus_tag="K6K39_RS04820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01016"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_221334032.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-37, bitscore:
                     128.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPPPDTDPATRQSLAHGPLGAALLDIERAHSGLIPYQIAHRKI
                     AGAGPLIDGDEASLFLGAPAMAYVLHMAAAGTERYAGALLTLDDVVAAHARRRLAAAHA
                     RIDKGRYTAFAEYDLFRGLTGIGALLLRRRPDGQELRRVLEYLVRLTEPVTGPEGESLP
                     GWWVGHAPANNQAATPGGHANAGLAHGITGPLALLALAKRRGITVDGHNLAMSRILRWL
                     DSIRQSDHRGTHWPRWVSRTGPAPTHSAAPSWCYGTPGIARAQQLAALSLGDDDHKRAA
                     EGALLYCLADPRQLDMLTSRGLCHGVGGLIRTVQRIAQDAETPAPFHNWLPEGSERFLA
                     APAPERPDLLEGVAGATLAFMAAESDGIAGTDWDACLLLI"
     gene            14186..15142
                     /locus_tag="K6K39_RS04825"
                     /old_locus_tag="EASAB2608_01017"
     CDS             14186..15142
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009315830.1"
                     /locus_tag="K6K39_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01017"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_221334033.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.9e-23, bitscore:
                     81.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLHHSRPDEGAVLAVLGGMPIEQAAQRVSMSAPLLAEAVERYRA
                     AGRAALEHTTAGWYQTYVTFADYPSAARAFRVYLLPAMQGEAVGAWWFVRKYPGWRLRV
                     LPALGSPVEMAVEHITRALDSAVSWGVAKEWRPSLYEPEIIAFGGAEGMTITERIFHTD
                     SAGVLTYDQLADDPPKGLLDAKATSLAVLTLFLRAAGLEWAEQGDVWGQVEAKRTLPAD
                     APLDKVGGLVNPMRQLLTLDPVPALVDGPLQPVAAWVDGMECGGRDLRSAAEANRLGLG
                     LRSILARHVIFHWNRMGFSIRQQAIWARAAREAILGR"
     gene            15290..15562
                     /locus_tag="K6K39_RS04830"
                     /old_locus_tag="EASAB2608_01018"
     CDS             15290..15562
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_01018"
                     /product="hypothetical protein"
                     /protein_id="WP_221334034.1"
                     /transl_table=11
                     /translation="MRHAHAAAPRTFKVAPGGPDVWGWQGPHLGRRFGQWWLRLVCAPQ
                     DKRNLRLWEGTATAHHALPPPVPRPRLHDVPEYVPLPARQVFSRA"
     gene            complement(15898..16338)
                     /locus_tag="K6K39_RS04835"
                     /old_locus_tag="EASAB2608_01019"
     CDS             complement(15898..16338)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662430.1"
                     /locus_tag="K6K39_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01019"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_221334035.1"
                     /transl_table=11
                     /translation="MPLTASAAVVFCNEDSEVLIVKPTYKDYWNLPGGAVDVEHGETPY
                     DAVVREVREELGISPPIGRLLVHAWVTVAGKGAQALYIFKGGVLSRQDMQALTLQQSEL
                     SEYRFCHPEEEPGLIPPHLTDVWDEATIAYATKRLNYVTANL"
     gene            complement(16347..17621)
                     /locus_tag="K6K39_RS04840"
                     /old_locus_tag="EASAB2608_01020"
     CDS             complement(16347..17621)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042915.1"
                     /locus_tag="K6K39_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01020"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_221334036.1"
                     /transl_table=11
                     /translation="MSVSDALVALITGLLLLQTAVRFPAALRGRHRGRSLSGAFAAFAA
                     AWWLRTDSGRFVIGQLGVHDLPTLLKHILAIVGICELLTYVSDVYHDEDTTARHIKITS
                     LVHRTAARASLATMLCLSAVFFLALDRSKTFVDSPYFVGRHVGEPALILYLGLFNAYTG
                     AAAAVCAHQWGRAARLAARKSLRTGLTMMAVGMTLLVLYSLLRTAYVTAITLHPALATA
                     GSVQEHITDYVLYAGFLLWILGSITPATHALASRLRAIKALVGLHRLWRDLVLAIDGIA
                     LHPPSMILGGHRAAAAINMLRDVLAHDTTPQIRLGRYVTEIRDATHELRRRAPSDLFQR
                     ARRLAETEGHTAQDADAVAEAYWLKSALRAADAPAGAPVAFHTASDDFASEVPWLQRVA
                     RAYRQAGPHIRPLLEAQPPRSVPTA"
     gene            complement(17608..18252)
                     /locus_tag="K6K39_RS04845"
                     /old_locus_tag="EASAB2608_01021"
     CDS             complement(17608..18252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662432.1"
                     /locus_tag="K6K39_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01021"
                     /product="hypothetical protein"
                     /protein_id="WP_221334037.1"
                     /transl_table=11
                     /translation="MWWSKLRGGWGGIPAAEGRAGSDRRTISRHTLRQECREVLAQMPV
                     PRPFTLDGLIASIEAERGRRIKLVAIPDYLLANTDVCGLWLQLDDVPVDLILYMEGTTA
                     FHRQRIILHELAHLWCDDVTEAGFEQLAGLLPDVPPDLLHRLTQRGRIMARHRYDSLVE
                     RRAEMLADLLHHEAYDVDYIENATLRRLDEDLSRLNFPLRPRTTEKNRVRL"
     gene            complement(18331..19050)
                     /gene="fabG"
                     /locus_tag="K6K39_RS04850"
                     /old_locus_tag="EASAB2608_01022"
     CDS             complement(18331..19050)
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-170). E-value: 1.2e-15. Score:
                     49.8. Matches aSDomain:
                     nrpspksdomains_K6K39_RS04850_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567714.1"
                     /locus_tag="K6K39_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01022"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_221334038.1"
                     /transl_table=11
                     /translation="MSRSILITGGNRGISHAAARAFAGMGDKVAFPCRSGEPAEDLVQR
                     GCLAVRCGVTEPEQVELAFKEAEAAHGPVEVLVANAGITRDQLLVRTSEEDFALVLETN
                     LFGAFRTAKRAVRSMLRARHGGIVLVSSAVAFKGEAGQTNYAAPKVGLIGFGRSLAREI
                     GSRGITVNVVTPGLTDTDMTAALDEGRGAAIVREVPLNRIGRPGEIASTIAFLASDAAS
                     YVTGAVVPVDGGISMGH"
     aSDomain        complement(18541..19041)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS04850_PKS_KR.1"
                     /evalue="1.20E-15"
                     /label="K6K39_RS04850_PKS_KR.1"
                     /locus_tag="K6K39_RS04850"
                     /protein_end="170"
                     /protein_start="3"
                     /score="49.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SILITGGNRGISHAAARAFAGMGDKVAFPCRSGEPAEDLVQRGCL
                     AVRCGVTEPEQVELAFKEAEAAHGPVEVLVANAGITRDQLLVRTSEEDFALVLETNLFG
                     AFRTAKRAVRSMLRARHGGIVLVSSAVAFKGEAGQTNYAAPKVGLIGFGRSLAREIGSR
                     GITV"
     CDS_motif       complement(18610..18669)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS04850_0002"
                     /evalue="2.80E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="K6K39_RS04850"
                     /protein_end="147"
                     /protein_start="127"
                     /score="16.6"
                     /tool="antismash"
                     /translation="VLVSSAVAFKGEAGQTNYAA"
     CDS_motif       complement(18910..19041)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS04850_0001"
                     /evalue="2.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K6K39_RS04850"
                     /protein_end="47"
                     /protein_start="3"
                     /score="10.4"
                     /tool="antismash"
                     /translation="SILITGGNRGISHAAARAFAGMGDKVAFPCRSGEPAEDLVQRGC"
     misc_feature    19199..19214
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.61"
                     /tool="antismash"
     misc_feature    complement(19320..19335)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    19342..19359
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.09"
                     /tool="antismash"
     gene            19358..20182
                     /locus_tag="K6K39_RS04855"
                     /old_locus_tag="EASAB2608_01023"
     CDS             19358..20182
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062442.1"
                     /locus_tag="K6K39_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01023"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_221334039.1"
                     /transl_table=11
                     /translation="MRSKVAEAPTISRILRQARARRDTSDIPGFTAAFGVRSRPGITQE
                     ETAKLAGVSRRWYNALESGRPANYSDAFLQAVRRILNLSSDEWHIVYRLTRGHTPIETP
                     VSPLTELLPDSVRDLVEQSEKWPLYVSDHRWDVLVYNAKILEIFPWMTYGLNVMEWALT
                     WPEARTQLIDWQTEWASPMVAQLRVHAEQYRTDQRLQAVIEVVLRDPVARKLWDSPDLP
                     LNVTHPVSHRPRRLYLPRQGGRQFAVRLMAFTPIELPSCRLMAITPSEPAKE"
     gene            complement(20509..21396)
                     /locus_tag="K6K39_RS04860"
                     /old_locus_tag="EASAB2608_01024"
     CDS             complement(20509..21396)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.5"
                     /locus_tag="K6K39_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01024"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_221334040.1"
                     /transl_table=11
                     /translation="MPARLFDAQALLLARRDENRKQSDVAEEVGVSAARVSAWETGRSV
                     PDPEKLPRLAAAVRRDLDQLFPRNGRPDLADLRADAGYSQSATRALTGTRTPGPVAAAE
                     NGQRRLSKEYEQRLADAYGVSVDALRRAQERSFGHDVPEPGESSSAQTTSAETGSGVLP
                     ATLAGKIAYLLDRMPAPVTDAALAARGNDLVGAEVLTEDLVHDLRTGVVASAPDEVLRA
                     LAEALDTTPLMFKSDDAGVERVIAETLVLRSQVAAIAARGGAEAGLSAELLAFIRKEVS
                     KAHREASAPHDHKG"
     misc_feature    21619..21632
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.14"
                     /tool="antismash"
     gene            22063..22974
                     /locus_tag="K6K39_RS04865"
                     /old_locus_tag="EASAB2608_01025"
     CDS             22063..22974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662427.1"
                     /locus_tag="K6K39_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01025"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_221334041.1"
                     /transl_table=11
                     /translation="MSSDAREWVWEHSSSRGTARLVLLSIADRVADDKCVAWASLTSLV
                     ERTRASRTAVRDALTALDKSGELKVLSHLEGPQRSTVYRLPRAAAWLAKVAAARRAAPD
                     AYVEPPADSDPVPELNEEAQKDLRRYGIWPKKGTEPAPSQRNPTGTESGPSRRNPTPRR
                     AGIRPQHGTESGPQNRREPKLNRKGSSSGAAVTSAADWQVDPASHTWARQQGHLDRLGE
                     DGLRAADAKWRAHRAGHAPRPAEAWAADWRAWVAREHAPSRPNPYALPGGGSAPAGGMT
                     RSEAHTAALLAALNEPTPAGTE"
     gene            22977..23669
                     /locus_tag="K6K39_RS04870"
                     /old_locus_tag="EASAB2608_01026"
     CDS             22977..23669
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070651.1"
                     /locus_tag="K6K39_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01026"
                     /product="hypothetical protein"
                     /protein_id="WP_221334042.1"
                     /transl_table=11
                     /translation="MDRREIAALLAYIGRLDPRTIRTDHAEARDQIAQWHELLEEVPLA
                     TPHGWDACVVARRHIRLSAYQILPADIARPWESYKRDRLHRHTDPTPAADPDDQAAWTA
                     ELVGTRRAVATGTAQPVQYRQLAGSRVNPRLEARLEQVGSCIPPEARAALAPFRRARAA
                     REAALAQGQPDALSVRCDWCQAPADEPCRRRRIGPDGFARGSAVRDEPHPCRKDLAATQ
                     QGQQTAMA"
     gene            23821..24468
                     /locus_tag="K6K39_RS04875"
                     /old_locus_tag="EASAB2608_01027"
     CDS             23821..24468
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070650.1"
                     /locus_tag="K6K39_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_01027"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_221334043.1"
                     /transl_table=11
                     /translation="MRHITTNTSPATGLRGIGDTSWQPHGVCHGMDPEDADATFFPLPR
                     DHEAIADAKELCALCPVRRDCLNYALENQLKEGIWGGLTEAERRPWHDGLPRRLDYSRV
                     VAFFNGRDVHLTDAERQVVIDHAYVCGWRPDRLAPALQISTKHARDLLRQAANKVFDRD
                     RALGVPRRKNITKKKTMVARRTRPATVPPATQQPLTRPATPTPAHAPVGKAA"
ORIGIN
        1 ccgccgactc aaaccctcac tcgccagctg aagcgctcag tcacatttga gccgaagcac
       61 gataggtgtc accgttgcgg tccgctgacc tggggttgaa cgcggcgcac agcagaacgg
      121 ttgtcaccaa agaggcggcg ctgttgtcac caaccccgaa tttgcaggct tgttgtcacc
      181 gcctccggcc accgtgcgag ttctgacctg cgatggactc gacctgtccc gtgcttgccg
      241 tggcagatga cgcgggcgag cttgtggggg gactcctggc cgccgggccg caggaaccgg
      301 cggtcctgaa cggcgggctc gtagcgcggc cgaagcggca gagggccgag ctggcctacg
      361 gggccggcct gccccccatc ggcatcgtgc acgtcagaca gcagcagtat ggctgcctgc
      421 gcccgtgagg gtggcgagtc aggcgagtgg ggtgggccgt gtcagccggc tgaaggggtg
      481 aggctggtgc ggtcgaacgg gccaccgtgc gcggtggcgt acgtgatggc gtcattgacg
      541 gcatcgaggc cgaacgaccg gacccgttcg ggggcgagat ccagagtgcc cgaggcgagg
      601 agccggatga tgccgacatt ggccgtgcgc gggtacatcc actgcccgcg cacggtgacc
      661 gagttgcgca tgatccatgg gtacgggagt gcgaggtcgc cgccaccgag catgccgacg
      721 ccgcccatga ggacgacgcg gccgtactcg cgcacggtca tggccgccgc acgcgaggcc
      781 gagctgggtg ccctcggcgg gagcaggtcg atcaccatgt cgatcgggcc gtcggccgcc
      841 gcggacatcg ccgcgcggtc ggtggcctcg tccccggtca gcgggaccgg gcgcagacgc
      901 ggaccgaacc ggtcggcgag gaggtcgagc acctccttgt tgcggccggg ggcgaccacg
      961 cggcccgcgc ccatcgcgaa cgcgaccgcg accgcgctgc tgccgaggtt gccggtggcc
     1021 ccgctgacga gcaaggtctc gccggccgcg agcccgcctg ccagcagccc gccgtaggag
     1081 atggtgtgca cggtgagcgc ggcccagcgg gccggatcct ccccggccgc ggcgggcagc
     1141 gggtagacat tctcagtcgg gacccgcatg agctcggcga acgcgccgtc gtgcaggtac
     1201 tcggcgagcc gcgcgccgcc ctcgccccgc gaactccagc cctggagcgt gatgtcgggc
     1261 gtcagcgcgt cgtcccgcga gcgcaccgtc gagtcgcacc acaccaggtc gccggcctgc
     1321 agccgggtgg cgtccgggcc gacgtggagg atccgcccca ccgcgccgac accgggtacg
     1381 acagggggga caagggggta cttccgtttg ccgctgaaga cttcggccgc gtagggcgcc
     1441 acgttggcgg cgaggacctc gaccaccacc tcaccgcccc cggcctcggg gtccggtacc
     1501 tcccgcaccg cgagcggggc gccgaaccgc gtcagaactg ctgctcgcac gtgatgacct
     1561 ccgtgttgtc cgtgctctcg agatcgaaac actaggagcg ggacgagcat gcgggaagcg
     1621 aggatccggc atccatggta tgcgtatccc gcatggacat ctccagtacg ggactgcggg
     1681 tcctgcggca gatcgccgag tccggcagct tcaccgcggc agccgcccgg ctcggataca
     1741 cgcagtcggc cgtctcccgc caggccgccg ccctcgaacg cagcgtcggt accaccctgt
     1801 tcgaacgccg tccggacggg gtacggctca ctcccgccgg cttgaccctg ctgcggcacg
     1861 cccacacggt cctcgcctcg ctcgcggcgg ccgagcgtga gctcaccggc accgtcccac
     1921 ggaccgaacc tgtacggctc ggggcagtcc tgagcgcggg ttcggcgatc ctgcccgccg
     1981 cactcgcaca cctcgcggcg gccgacccgc agatcacggt caccacccgc gagggcacca
     2041 cacccaccct gatccgggcg ctgcgcgcgg gctcgctcga cctcgccgtg ctgacatccc
     2101 gaccgcccca ccggcccttc gacggcgact cgccgcggct gcaccttgag accgtcgcgg
     2161 acaccgagct ggtcgtggcg gtgccttcga ccggagagtt cgccgggcgc accacggtgc
     2221 acgtcgagga gctggtcgat gccgcttgga tcgccacccc gtcatcaggc ggcgagccgc
     2281 tgctcggcgt ctggcccggc ctgcccggac ggccgcgcat catccactcc gcgcgcgact
     2341 ggctgaccaa actccagctg gtcgccggcg gcttcggcgt gaccacagtg cctttccccc
     2401 tctcaccggt actgccgccg ggggtaagcc tgctgcgcgt cgacggcgca ccccgcgaga
     2461 tccgtcgtgt gctcgtggca cgactcggcg gccaccccac tccggcgatc acgaccgtca
     2521 cccgagcgat caccgcgacc gtctgaaccg ccgccaccgc cggcctgttc ttcgcggtac
     2581 tgacacccgg ctccgccgcc gtcacagctt ggcatcacgt acatgacggt ccaacctgcg
     2641 gacacgcgag cgagctggcc cgggctcgca gcccggggcg gactgctaca gcgaactcca
     2701 agtgctctac actgcccgcg gcttcgcctg agcagttgcg tggacaggtc gaggggaatc
     2761 cgggccgctg ccctcacaag gcgaagcggc ccaaaaccac ctgtccgaag ccgaagaatg
     2821 ggaacgctca aacggccgac tggcagctca ccggcaactt cagtcactca gtcgcaccag
     2881 cccggtgcac tctgtccgag gggcctggtg acaacacttc ctgggtgaca gctatcgtgc
     2941 ttcggctcaa catttcggct caagcaggtc cacatttcga ccgtgtcaga actgcaaatc
     3001 tctggactgg acatgcgcga tatccccgca caaacccccg ggtcgggtgc tgctgcccgg
     3061 ggatcagggg ctcgtcgccc acctctggta ccggtgccag gcgcccgacg gctggaggta
     3121 cgaggtcggc ctgccggacg gggcggcatc tgcctaaccg ctgccctggc ccgtcccgtc
     3181 cgatcgggtg atcctccggc ccacgactgc aagccccttg caccgttgct gcgcgagacc
     3241 agggcctggc cgccgggatc cagcccgccg acgccggcgg tgaggccgaa gcggccctct
     3301 cccggacgcc gggtgtcccg tgggatcgtg gcgggcgccg gatcgagggg ggagcggtga
     3361 cgttgacgcc tgaagccggt ttcggcgttg ctggtgcgga ccgggtgcac ccgcgggcgg
     3421 aggcgatcgg gcgccggctt caggcgtggg cggccgcgct gtccctggcg agggatgcgg
     3481 ccgggcgcgc acgccttcgc gcggcgggct ttcaccggat ggcggcccgc gtaatccccg
     3541 acgctcccac cggggacgtt gagcggctgg cctggtggat caccgtcctg gtcaccgcac
     3601 gacggggcgg ctgccagccg gtcagatgtc ccgtggacag cagcacgagc cgcatgtcgc
     3661 gcgtggtcag caacccggcg ttcaggcggc gtaccccctc acggaccacg gctggatcgg
     3721 cctcggtccg gccggcgagc tgcttgagct tctcgtccca ctcgtcggcg tccagcaccg
     3781 ccaacccatg gtcctgcgcc ctcgtctcgg ttcgctgacc gccctcagcc gcagaacgca
     3841 gtcccgctcc acttcatccg gcgtcgcagt gccgggcagg gtagttgtcg gcaatgacct
     3901 cgcgacagta aagggagagc gccgacaccc gtcgccgttc ggcaccggac acggccccag
     3961 ctcgtttttg aacaccacaa cgcgcccggg tactggggac atctgcggct gctcagtggt
     4021 gtgctcctct actttgtccg tcggcgtggc ccctcgcgtt gttaggcgct ggcctcctcg
     4081 ctccaggccc atgaaccggc ccgatcgggt gatggcggac aagcgctagt cgtccacgaa
     4141 gatccgcgca tacctgcgca ggcgaggcat cagggcagca atccccgaac ggaccgacca
     4201 gatcaacggc cgcatccggc gaggctaaag ccgcgccagc tcgaccggac tgcctaccgg
     4261 cgccgcaacg tcatcgagcg ctgctttaac cggctcaagg tgcgacacga agtcgcacct
     4321 tgagcttgtt gatgcaccgc tcgaccgtgt cccgctgctt gtacgcctcg cggtcgaagg
     4381 tcggcgggcg gccaccgagg cggccgagcc acctgcggtt cgcggcctgg tctgcaagca
     4441 gcgggattac cgccctgatg ccgcgccgac ggagttggtc gcggatcgcc cgggacgaat
     4501 acgccttgtc ggccaagacg atctccggcg tggtcctggg tcggccgacc ggccgggaca
     4561 ccctcagacg ggccgtgacg tggggaaacg ctggggcgtc acctgcctgg ccgggcgtga
     4621 tgacaaaggc gagtgggcgg gagcggctgt ctgcgacgag gtggatcttg gtggtcaagc
     4681 cgccgcggga ccggccgagg gcatgacggt ccggctcggc ggccggagcc ccctgaccgc
     4741 ctgcggcata cggcatgagg ttggcttcgt cagctggtgg agactgtccg cggcgggcca
     4801 ggtggaaccc tcagtagggg cgcggatctc gtcgggccag cgcatggcgt gcaggaggac
     4861 gtcgtcgtgg acgcgcagta gaccgagccg ctcccagccg ctacagacgt acttggcgac
     4921 ggccaccttc gccgatcgcg acagggcctt caccagcagc ttgtacggct tcgcggcgac
     4981 ctggccggcg ggctgcaggt agtagccctc agcgatcttc agtgggtcca ccgactccag
     5041 cgggacgaac gcgtcgaacg gctcccttga caacgcaagt ctccagccca ccgcccgttt
     5101 tcggaacacg agggccgctg ggtagtgtcg agattcaccg acctggaaag ggcagttgca
     5161 tggccagcga catcgtgatt gcgcagacga ccattgacga cgaggaacag gccaaagccc
     5221 tcgcccgcgg tgcggtcgag agccggttgg cggcctgcgc ccacatcgac cagccgttcg
     5281 ccgcgacgta ctggtggagg gggaccatcg agaccgcaca agagtggcgg atctcgtaca
     5341 agacgacgac agagcggctc ccggagctgg aggcctgggt cgcagagcag cacagctacg
     5401 aagtaccgga atggatcacc ctcccggtga ccggtggatc cgaggcctac ctgaagtggg
     5461 tggtcgacga gacctcaccg cactccgccg agtaacagct cacgccgcga actgtcgcag
     5521 gtgacgggcg agttcacgct cactggccgg aagctgagct gcaacggcct gggctcgagc
     5581 tcgccccatc gtggtgggcc gggcgtcact cgccgcggcg aactggcggg acacgtagac
     5641 gccctggtcg acgtctcccc cgcgcaacag tgcattcgcc aggtcgccga gcacgacgac
     5701 gcccgattcg ggtagctccc tacccagccg gtctacggcc tggtccgcgg tttcggccag
     5761 ctcctgccga ccgagttgac cgtacacaga caacgccagg gagtccatcc gatacggggt
     5821 gacgaagcga acccacgcct gctcggccgt gtgatcggcg aattcgtacg cgaagcgggc
     5881 ccggtccaag gcgcggaggg cgttcgtgtg atcgccgacg ctcgccgcct cttccgcgag
     5941 cctgccgtag agccaggcag cggcagccgc gttgccctga ccccggacgt ccttggtggc
     6001 ttggatcaac aactccgcgg ccttctcggg ggtcgcggct ccgtagctgg cgtaacccag
     6061 cgcgagggcc cgcaggggtg ggtggccgat gttcttggcg cagtccatgg tgaccttgta
     6121 gaaggcgtgc gcccggggct catcccccag gtcccacgcg acccatccgg ccagggctgc
     6181 cgtctcgccg gccgcgatcg tcaaggcccg ctcgttctca ccggctcgcg gtagcgcggc
     6241 cgtgatcgcg tccaggtgtg actcaacttc gctctgcagc tcccgagcag tcaggtggct
     6301 ttcgcgtacg tggagttcgc aggctcggtt gacgaggctg ccggctgctt tcgagtcgat
     6361 ctccttgccc ctgctgaggg cgtgcgcgag gcgttcccac ggttctgtag cggcggctgc
     6421 gccaacggcg gcgcctccaa gcagtgtgcg gcgtttcacg tcgtcctggt cctccccttc
     6481 aggccgggcg cccttcctgc gcctggcgcg ggcggctgcg gcctcccgct gcaggtgttc
     6541 aggggataag ccacaagcca ccgcaatgtg cgcgagcgtg tggttcgtcg ggatgttctg
     6601 gccgtgctcg tagcggttga tctctcgccg ggtcatggtg tcccggcctg agaccgcgtt
     6661 gatcgcggct gcctgctcct cctgcgtacg cccggcgtcc ttgcggagcc gaacaaggag
     6721 ctcagcgaac tggtccgttg ccatgagtgt gacctcgtcg tcgggtggaa accaatcatg
     6781 gccccaactt cccccgctgg tttccccctt gactggattt tccccctctg atttcccctg
     6841 gcagggaact cggactcgcg aaacggtgag tccatgacca cgatccgtaa ggttctcgtc
     6901 gcagggcgcc cgctgccggc gcaccaggct gcgaacgcgc cgcccacccc ggcacagtgg
     6961 atcgccctcc ccctggacag cgttcgcacc gtccagcggc gcggcgagct ggacggctgc
     7021 agggactcgt ggtggggcct gaccgagact ccggccgtca cgacgtgccg gcaggcccgg
     7081 ctcagtagcg atcacttcag cgtcgtcgct cacgtgcgaa cgcgtgccgt tctcggcatc
     7141 tgtctgtgat gccccatctc tccagaagga ggtcactcca tgagccccag cgcgagcgcg
     7201 ccgccactca agacccgcgt gcccgaccgg acggggaaga aggtcaaggg catcagggac
     7261 tggacacctc cgcaccagcg agaggagatg gagcggctcc tggagcgcct acgggccggc
     7321 ctcccggtcg acgcggcgta cgacgacctc aacgaggtgc tcggtgatgg gccggcgctc
     7381 accgacgaga ggattgagga actcacggag cggttccgcg gcagcctcat ggtcctggtc
     7441 gaccaggtgc gtgagcgtgc gcccggtgac gcgcaggaac gcgaggcgct cgtcgagaag
     7501 gcgcgcatgc tgcgccagga gaacgccacg ggctcaccgc tcggtttcct gcgtcgactg
     7561 gcattcagcg ccgaagcgct cctggacctg ctcttggacg aggagccggc atcgtgacgc
     7621 ccccgatgca gcaggtgcag tgtggggtcg atgtgctgcc ggcgggcgag gcgtacgact
     7681 atgactactt ccgtgtccgg ctcggagacg accagctctt gaagcgcagt gtcgccctgc
     7741 gggtgtaccg aatgccgttc ctcgccgtcc ccatcggaag gacgcggcgc ggcgggttct
     7801 tcccccttta cgacctcgcg gccgcgtcgg cggtatgcgc ggccctcgaa ccgctcaacg
     7861 gcttcccggg gctccgcacc gcctgggtcg ccgcaccggt cgccgctcac gcagttgagt
     7921 ggggagaccg ccctccgctc aggtgggaca ccgaggggca gcgccttgct ttctacggct
     7981 tcactcaacc cggcccccgg ccggccccag tccccctctc cggctagctc caaccgttcc
     8041 cccacggcct caagagcacc gaagagggac cttcctgcac cgcgcacgtc cgaaaggaag
     8101 agctccatgt gtcggcacga acccccctgt cctaccgctt ccgcggccga tcgtgacgcg
     8161 gccgccaccg tagtccgtca cgacgaacag ggctgggcgc tgctgtgcaa cggcgttctc
     8221 cgcttcgacg acaccggcga cctactgccg gacggtcgcg tcatcgcgcc gcaccggccc
     8281 gccgcctaga acgaccgtcc ggcggcccag acgtgacggg tcgggccgcc ggacggttct
     8341 ccaccccggc gtgcacccgc gccggccacc gcaccaccag ccagcaaccc tcggcgcgcg
     8401 gacgccgaga aggagaccta cgtggatacc gtccccggca tgacgaccga gaacttccag
     8461 accccgcacg tgtccgagca agagctacgt gacgccatgg tgcagtgcct catcgacatg
     8521 gggacacttc gcacttcacg ggcggtagcc gccttccgta cggtcccccg gcatctcgcc
     8581 gcaccgggaa cggacatggc caaggcctac gacgtcgagt ccgcgctcat caccaagacc
     8641 gatccgaccg gcgtgggcat cagctcggtg tcggctccga ggattcaggc catgcagatc
     8701 gagcaggccg acatccagct cgggatgaac gtcctggaga tcggttccgg cggggtgaac
     8761 gccgcctacc tcgccgagat ggtcggggac cagggccgag tcgtcactgt ggacatcgac
     8821 ccggacgtca cggcgcgtgc acgggacttc ctgaagacga ccggacaccg caacgtcacc
     8881 gtgatcaccg gtgatggcgg aagcggcgcc ctcgactact caccgttcga tcgcatcatc
     8941 gtcaccgtgc aggccgccga cattccctcc tcctgggtgc accagctcag cgaagggggc
     9001 cgtctcgtcg tccctctgcg gatgcgcggc atgacgcgct ccgtcgcctt cgtccgcgac
     9061 gaccagcgcc tcaccagtga cggcttcgag ctgtgcggct tcgtgccgat gcagggtgtt
     9121 ggcgagaacc gcatgcgcgt tgtcctcctc cacgacgtcg agggtgagga gatcggcctg
     9181 cgcctggacg accatcccga gcccgacgtt aaggccctgg cggaggcgct gcggacgcca
     9241 cgttgcgaag agtggtccgg agtgaccctc gccggagacg aatccaacga gcacctggac
     9301 ctgtggctgg ccaccgcgtt cgacagcctt cccctgatgg ccgcacaacc ggccgcgcgg
     9361 gagcggggcc tggtcgcctc tgcctctccg ctcggtatcc ccacgctggt ggaaggcggc
     9421 agcttcgcct accgcacggt ccggcgcacc gacgacccca accgtttcga gctgggcgca
     9481 tatggccacg gccctgacgg gcagaagacg gccgagcgcc tggttgaggc gatccgcacg
     9541 tgggaccgcg agcaccgcgg cgaccgcgcg cacatcgacg tctacccggc cggcaccccg
     9601 gacgagcagt tgccgctcgg cgcccgggtc atcgaccgtc cgcactcgcg gatcacgatc
     9661 tcctggccgt gacgctgcca gcgtcgcgcc caggtcggta aggcacatcc accccctctc
     9721 atgacgagga gaacgagatg gcaccgcaga acagcaccgt ccccctgaag gccgcgaccg
     9781 acttcaccgg cgatggtgga tcggacttcg acctcagggt cgagaccgtc gcgtccgtgg
     9841 ccgtgcccgg ggcactgctg aacgacaccg gcgacggctg cggctcgacc tgccagtccg
     9901 cgtgcgccaa cagcacctgc atcggcggct gacgtaaccc ccgtgggggc cgggccagcg
     9961 aggtccggcc ccacccaccg tgcactgagg aggcatagcc atgtaccacg cagttgacgc
    10021 gggcatgatc aggacgtctg cgtttcccct gtcggcgacg ctgcctcctt ggccggactt
    10081 ggacggcggc agcgcaaccg acgtctccct gtggaaagag tggatcaccc aggtctgggc
    10141 cgacgacaca cgggccgctg ccgtcgaagt cgccagtccc ctccttgccg actccatccg
    10201 ccaggccctc gacgacgagc gcacacgacc gcgcgccatc cgccgcacgg ttatctccct
    10261 agctcgctac ctgttgcgca tgcagtaccg cgctactccg tctgggctgc tcgccggacc
    10321 cgcacccctg cgtatcggcc cgacggcaca agccatctgg ggaacagctc atcgagcatt
    10381 cgcgcgagcc gactcccagt ggttgcacga cgtcgtcgcc accctcgaac gagatccgca
    10441 ggtcctgcgc tacctgcccg tggtcgtcaa ccccacgtgc accgtacgag gtggacgcgt
    10501 caccgtgctc caccagccgg gagccgatgg tcctaccgac accaggatgc ggcgtacgcc
    10561 agccatcgaa gcggtgctga ctctggcccg ttctgagatc actgtcggcg acctcgcgga
    10621 caagctgtcg agcgagtacc ccgacaccga catcgcggtg atcgagaaca tgctgcgcga
    10681 cctcgtcgcc caccgggtcc tgctgagcac cctgcacgct cccatgacgt gcgaaaacgc
    10741 gctcggccac ctcatcgacc ggcttgaagt cgccgacgtg gccagcgccc cgacacggga
    10801 gctacggcag atcagcacgc tgctggcctg gcacgacacc gcccccgtgg aagagcagcg
    10861 gtccctgcgc gggcggacca cggcgaagat gatcgcgctg acggccatcg cggaccggac
    10921 gctggccgtg tacctgcggc cggactgcga catcgtgctc cccgaggcag tgacctgcga
    10981 ggctgagaag gcgctggaag tcatggcacg ggtgacgcca ttccccagcg gctccccggc
    11041 ttggaaggac taccgcaccc ggttcctgga gcggtacagc atgggcgcca tcgtcccact
    11101 gcgcgatctg atcgacccgg acaccggcct cggctacccc gtgagctacc gcggcaccct
    11161 gctgaagcgc ccggtgctgg ccaccacctg gcgcgacgaa cacctcctcg ctctcgccca
    11221 gaacgcagcg ctcaatgacc aacgcgaagt cgtcctgaca ccagaggaca tcgcagcttt
    11281 gtcgctcggc gagcccgacc aggtgcccgc gcacgtcgag ctgtgcttca gcgtgctctc
    11341 gccctccctc gaagacctga accgcggaga cttcgtcctg tccacggtgg gcctggcgac
    11401 cggtgccggc accaccaccg ggcgcttcct gagcatgctg gagcggcccg accgggaacg
    11461 gatgatcgcc gcgtacgccg gtctgcccac cctcacagtc ggcgcagagc gcggccaggt
    11521 gtccagtcct ccgctgcgcg tgcagacgta caacgtcggc cgggccccgg cgatcgtgcc
    11581 gaacgtgcta gctgtgggcg agcacaacct ggacgcgtca ctcaaggtgg acgacctcgg
    11641 cgtcgtcgcc gactcccagc ggctttacct ggtgtcactg tccaccggcg agccgatcga
    11701 gccctccgtc atgaacgccg tggagctcag caacgccacc caccccctgg cccgcttcgt
    11761 gtgcgaactc caccgctctc acacagcggt tctcgtcccc ttctcctggg gtgccgcagc
    11821 ccagttgccg ttcctgcccg aggtgcgcat cggccgcacc atcctgtcct ccgcctgctg
    11881 gcggctgcgc acccgcgacc tcaacggtgg cggcctgtgg tcctggcgct tcaccaactg
    11941 gcgcgtccgc tacggcgtcc cccgcaccgt ctacctcggc gccgacgacc gacggctcag
    12001 actcgacctc gacgtccccg cccacgtgca gctgctccgc gccgacctgg aacgctacgg
    12061 catgatcgtg ctgcacgagg cgccgccgga ggaggccttc ggctgggtgg gccgcgcgca
    12121 cgaggtgacg atccccttcg ctgccgagca ggctgccgcc tcgccgcccg cgtttcgccc
    12181 tgaggccgtg gtgaaccggg acttaggccg gctccccggc ggctcacggt gggcgtactt
    12241 gaagctctac ggaaatccag accgtgccga cgaggtgttg acaccccact tgccgcggct
    12301 actcctggag ttcggtgccg aagcgccgga cgtgtggttc agccgatacg ccgatcccga
    12361 cagtcaccta cgggttcgtc tgcgcctgtc gtcaccggag gccttcggcg aggccgtaca
    12421 gaagaccgcc gtgtgggcgg atgaactacg ccgcgaggga ctcatccagc gggtgcagtg
    12481 ggacaccgac accccggaga tcggccggta cggcacgggc cccgtgctgg aggccgctga
    12541 acgctacttc acagccgatt ctgctgccgt cgtcgcccag ctcgtcctgc ccattcccgg
    12601 ccactgcaag ccggcggtca ccgcggcgag catggtggac atcgccaccg tcttcctcgg
    12661 ctctccccag gctggccggg cgtggctgac gatgaatttc cgcaacagcg agggcgccgc
    12721 gtcctcccgc gacgcgcaag cactggccat cctcctcaca ggtgccgatg taggcgagag
    12781 ggctgccgcg ctacgtcaac tcccgcgcgg ccagcacgtc gccggcacat gggcgctgcg
    12841 ccgcaggctc ctcgacgagt accgacaagc actccaaacg gccgacatcg accccgccac
    12901 cgtgctgccg tccctgcttc acatgcacca caaccgcgca gcgggcatcg acccagacgc
    12961 cgaagccaca tgccgccgtc tggctcgtac cgccgcactg tcctggaccg cccgcgcaga
    13021 aggagccccg cggtgaccac ccccccgccc gacaccgacc ccgccacccg gcagtccttg
    13081 gcgcacggcc cgctcggcgc cgccctcctc gacatcgagc gcgcccactc cggactcatc
    13141 ccctaccaga tcgcacaccg caaaatcgct ggagcgggcc cgctcattga cggggacgag
    13201 gccagcctgt tcctcggcgc ccccgcgatg gcctacgtcc tgcacatggc cgccgccggc
    13261 accgaacggt acgctggagc gcttctcacg ctcgacgacg tcgtcgcggc ccacgcccgg
    13321 cgccgtctgg ccgccgcaca cgctcgcatt gacaagggcc ggtacaccgc cttcgccgag
    13381 tacgacctct tccgcggcct gaccggcatc ggcgccctcc tgcttcgccg tcggcccgac
    13441 ggccaagagc tgcggcgcgt actggagtac ctggtccgcc tcaccgaacc cgtgacaggc
    13501 ccggaagggg aatcactgcc cggctggtgg gtcggccacg cgccggcgaa caaccaggca
    13561 gccaccccgg gcggtcacgc caacgctggt ctcgcccacg gcatcaccgg ccccctcgcc
    13621 ttgctcgccc tcgccaaacg ccggggaatc accgtggacg gccacaacct cgccatgagc
    13681 cggatcctgc gctggctgga cagcatccgc cagagtgacc accgcggaac ccactggcct
    13741 cgctgggtca gcaggaccgg tccggccccc acgcacagcg ccgctccctc gtggtgctac
    13801 ggcactccgg gaatcgcccg cgcgcaacaa ctcgccgccc tctcccttgg cgacgatgac
    13861 cacaagcgcg cggccgaggg tgccctgctg tactgcctgg ccgatccccg gcaactcgac
    13921 atgctcacca gccgcggcct gtgccacggc gtcgggggac tgatccgcac cgtccaacgg
    13981 atcgcgcagg acgccgagac ccccgcaccg ttccacaact ggctgccgga ggggtccgaa
    14041 cgcttccttg ccgccccggc acccgagcgg cccgacctcc tcgaaggcgt cgccggcgcc
    14101 accctggcct tcatggcagc cgagtctgac ggaatcgctg gcaccgactg ggacgcctgc
    14161 ctgctgctga tctaggagac gccagatgca gctacaccac tcccgccccg acgagggtgc
    14221 cgtgctggcc gtcctcggcg gcatgcccat cgagcaggcg gcccagcgag tatcgatgtc
    14281 agccccactg ctggcggaag cggtcgagcg gtaccgcgcc gccggccggg ccgccctcga
    14341 acacacgacg gcaggctggt accagacgta cgtcaccttc gccgactacc cgtccgccgc
    14401 gcgagccttc cgtgtctacc tcctgcccgc gatgcagggc gaagccgtgg gcgcctggtg
    14461 gttcgtgcgc aagtacccgg gctggaggct gcgcgtcctg cctgccctgg gctcaccagt
    14521 ggaaatggct gtcgaacaca tcacgcgggc gctcgactcg gccgtgtcct ggggggtggc
    14581 caaggagtgg cggccctcct tgtacgagcc ggagatcatc gccttcggcg gggcggaagg
    14641 catgacgatc accgagcgga tctttcacac cgacagtgcg ggcgtgctca cctatgacca
    14701 gctcgcggac gatccaccga aaggactcct cgacgccaag gccacatccc tcgccgtgct
    14761 cactctcttc ctgcgggccg caggactgga gtgggctgag caaggtgacg tctggggcca
    14821 ggtggaggca aagcggacgc tgcccgccga cgcaccactc gacaaggtcg gcggcttggt
    14881 gaacccgatg cgccaacttc tcacactcga tccggtccca gcgctcgttg acggcccgct
    14941 ccagcccgtt gccgcctggg tggatggcat ggaatgcggc ggaagggatc tcaggagcgc
    15001 tgccgaagcc aaccgcctcg gcctcggcct cagaagcatc cttgcacgcc acgtgatctt
    15061 tcactggaat cggatgggct tcagtatcag gcagcaggcc atctgggcgc gcgccgcacg
    15121 ggaggccatc ctcggccgct gaccgatccg ctccgcagtt gacgtaacgg actgggtggc
    15181 tcccgcgtct cccagaatga ccacggcctt ggagcgggcc cggaattctt ccggttcccc
    15241 gtccacggcg gtgttcgtgc caccgcacgc ccgcgatgac caggtccgga tgcgtcacgc
    15301 ccacgcggcc gcgccccgga cgttcaaggt ggcgcccggt ggcccggacg tgtggggctg
    15361 gcaggggccg caccttggcc gccggttcgg ccagtggtgg ctccgcctgg tctgcgcgcc
    15421 gcaggacaag cgcaacctcc gcctgtggga gggaacggcc acggcccacc atgcgctgcc
    15481 cccgcccgtg ccacggccgc ggctccacga cgtgcccgag tacgtgccgc tgcccgcccg
    15541 tcaggtgttc agccgtgcct aaaccagtac ggcgtgaaca tccgcccttg aggacccggc
    15601 cagtacaggg gatacccgcg ccgacaccag gaggagcccg cagccggccc gccgggggtt
    15661 tgccccggag gtcacccgtc gtctaggcgg tgtgccatcc ccggcagacc gccacgtcgg
    15721 gggaacgccg tcacgagcgg cggagcctgt cgagtatcac gctgcactcc cgctccgctc
    15781 cgtctacctc tctcctgcac ctgccctcct ccggcaggcc ccgtcctggg cagtcagcaa
    15841 gagcgtgctg ccagggcggg cctgccagtg agatggctgt gcgaagcgga cgatcagtta
    15901 caggttcgca gtgacgtagt tgagccgttt cgtggcgtac gcgatggtgg cctcgtccca
    15961 cacgtcggtc aggtgcggcg ggatgagacc gggctcctcc tcggggtggc agaaccggta
    16021 ctcgctgagt tcgctctgct gcagggtgag cgcttgcatg tcttggcgac tgaggacgcc
    16081 gcctttgaag atgtacaggg cctgtgcgcc cttgccggcg actgtgaccc atgcatggac
    16141 cagcagtcgt ccgatgggcg ggctgatgcc cagttcttcg cgaacctcac ggacgaccgc
    16201 gtcgtacggg gtctcgccgt gctcgacgtc gacagcgccg cccggcagat tccagtagtc
    16261 cttgtaggtc ggcttgacga tgaggacctc actgtcctcg ttgcagaaca cgacggcggc
    16321 tgaggctgtc aggggcatga tctttcctat gcggtgggaa cagagcgagg aggctgggcc
    16381 tccagcaggg ggcggatgtg gggaccggcc tggcggtacg ctcgggcgac acgctggagc
    16441 cagggaactt cggaggcgaa gtcgtcgctc gccgtgtgga aggccacagg cgctccggcg
    16501 ggtgcgtcgg cggcgcggag tgcggatttg agccagtacg cctcggcgac ggcgtcggcg
    16561 tcctgggcgg tgtgcccttc ggtttcagcg agccggcggg cgcgttggaa gaggtctgat
    16621 ggagcgcggc ggcgcagttc gtgggtggcg tcgcggattt cggtgacgta gcggccgagc
    16681 ctgatctgcg gggtggtgtc atgagcgagg acgtcccgca gcatgttgat ggcggcggcg
    16741 gcgcggtgac cgccgaggat catgctgggt gggtgcaggg cgatcccgtc gatggccagg
    16801 accaggtcgc gccacagtct gtgcaggccg acgagcgcct tgatggcgcg cagccgggag
    16861 gcgagcgcgt gggtggccgg cgtgatggag ccgaggatcc agagcaggaa tccggcatac
    16921 agcacgtagt cggtgatgtg ctcctgcacg gagccggccg tcgcgagggc cgggtggagg
    16981 gtgatcgccg tgacgtaggc ggtgcgcagg agggagtaca ggaccagcag tgtcatgccg
    17041 acggccatca tggtcaggcc cgtgcgcagg ctcttgcggg cggcgaggcg cgccgcgcgg
    17101 ccccactggt gggcgcagac ggcggcggct gcgccggtat aggcgttgaa gagtccgagg
    17161 tagaggataa gggcgggctc gccgacgtgc cgtcccacga agtacgggct gtcgacgaag
    17221 gtcttggagc ggtccagagc caggaagaac acggcgctga ggcacagcat ggtcgcgagc
    17281 gaggcccgtg ccgccgtgcg gtgcaccagc gaggtgatct tgatgtggcg cgcggtggtg
    17341 tcctcgtcgt ggtagacgtc gctgacgtag gtcagcagtt cgcatatgcc gacgatggcc
    17401 aggatgtgct tcaacagggt gggcaggtca tggacgccga gctggccgat gacgaagcgt
    17461 ccgctgtcgg tgcgtagcca ccaggcggcg gcgaaggcgg caaaggcacc tgacagggag
    17521 cggccccggt gccggccgcg aagcgcggcg gggaagcgga cggctgtctg caggagcagg
    17581 aggccggtga tcagtgcgac gagcgcatca gagacggaca cggttcttct cggtggttcg
    17641 cgggcggagg gggaagttca gcctggagag gtcctcgtcg aggcgcctga gcgtggcgtt
    17701 ctcgatgtag tcgacgtcgt aggcttcgtg gtgcagcagg tcagccagca tctcggcgcg
    17761 ccgttcgacg agggagtcgt agcggtggcg ggccatgatc cggccgcgct gggtgagtcg
    17821 gtgcagaagg tcgggaggga catccggcag gaggccggcg agctgttcga agccggcctc
    17881 ggtcacgtcg tcgcaccaca ggtgggccag ctcgtggagg atgattctct gccggtggaa
    17941 cgctgtggtg ccttccatgt acaggatcaa gtcgaccggg acgtcgtcca gctggagcca
    18001 caggccgcag acatcggtgt tggccagcag gtagtcaggg atggccacga gtttgatccg
    18061 ccggccgcgt tcggcctcga tgctggcgat caagccgtcc agggtgaacg ggcgtggcac
    18121 cggcatctgc gcgagtactt ctcggcattc ctgccgcagc gtatgccggc tgatggtccg
    18181 cctgtcggac ccggcgcggc cctcggcagc cgggatcccg ccccaaccac cgcggagctt
    18241 cgaccaccac atcgcgcgtc atcgtctcct tactccccgt tgcgctgccc acggccccgt
    18301 acggcgcggg ccagtccacc tctgcgcatt tcagtgcccc atggagatgc caccgtcgac
    18361 cggcaccacg gcgccggtga cgtaggaggc ggcgtcgctg gcgaggaagg cgatcgtcga
    18421 cgcgatctcc ccggggcggc cgatccggtt cagcggcacc tcccgcacaa tggctgcgcc
    18481 cctcccctcg tcgagggcgg ccgtcatgtc cgtgtcggtc agacccggtg tcacgacgtt
    18541 gaccgtgatg ccccgggagc cgatctcccg cgccagggac cggccgaagc cgatcaggcc
    18601 gaccttcggc gctgcgtagt tggtctgccc ggcttcgccc ttgaaggcga ccgcggagga
    18661 gacgaggacg atcccgccgt gcctggcgcg cagcatgctc cggaccgcgc gcttggccgt
    18721 ccgaaaggcg ccgaagaggt tggtctccag caccagcgcg aagtcctctt ccgacgtacg
    18781 cacgagcagc tggtcgcggg tgatgccggc gttcgccacc agtacctcga ccgggccgtg
    18841 agccgcttcg gcctctttga aggccagctc cacctgctcg ggctcggtga caccgcagcg
    18901 caccgccagg cagcctcgct ggacaaggtc ctccgcaggc tctccgctgc ggcaggggaa
    18961 agccaccttg tcccccatac cggcgaacgc gcgcgccgcg gcgtggctaa ttccgcgatt
    19021 tccgccggtg atcaatatcg agcgggacat gaagctcctt tccgtgatcg agagatacaa
    19081 accgccagct cagaggggcc ggcttggctg tgtcggtgac cttaggacgc aaacggagga
    19141 gcaatgcgag cccgttgcag cgcttatcct tctcatgaga actgacagtt cccatcaccc
    19201 tggcctagac cacttgtcga cgacaggtcg cctattcgga ctttgcgtca actcacctaa
    19261 gttatttgac cattgactcg aagtgcgagc cgggacgggg taatgggtcg aggtgggcat
    19321 gtgacgtgaa tcccaccacg agcgttacag gaatgttatg cgtagcaagg ttgcggaggc
    19381 cccgaccatc tcccgcattc tgcgacaagc ccgtgcgcgt cgtgacacat cggacatccc
    19441 ggggttcact gcggcttttg gagtcagatc ccgaccaggg atcacgcagg aggagacagc
    19501 gaagctcgcc ggcgtcagcc gccgctggta caacgccctg gaatccggcc gaccagcgaa
    19561 ctacagcgac gccttcttgc aggctgtacg gcgcatccta aatctcagct cggacgaatg
    19621 gcacatcgtc taccgcctca cccgcgggca cactcccatc gaaacccctg tcagcccgct
    19681 gacggagttg ctgcccgact ctgtccgcga cctggtcgag cagagtgaga agtggcctct
    19741 ctacgtcagc gaccaccggt gggacgtcct ggtctacaac gccaagatcc tggagatctt
    19801 cccctggatg acctacggcc tcaacgtgat ggagtgggcc ctcacctggc ccgaagcacg
    19861 cacccagctg atcgactggc agacggagtg ggcctcgccc atggtggccc aactacgggt
    19921 gcacgccgag cagtaccgca ccgaccaacg cctccaggcg gtcatcgaag tagtgctccg
    19981 cgatcccgtc gcgcgaaagc tctgggattc ccccgatctg ccgctgaacg tcacccaccc
    20041 ggtatcacac cggcctcgcc gtctctacct gccgcggcaa ggtggacggc agttcgccgt
    20101 acgcctcatg gccttcactc ccattgaact cccctcctgc cgcctgatgg ccatcacgcc
    20161 atcggaaccg gcaaaggaat aaccggattt catccagcag gagcgccaaa ggccataaaa
    20221 acgcggcagc ttgacccatc atcaggtcag cgagtttgcg tactcgatgc tattcgatgc
    20281 gcgctcgttt ccggcgatcc ctggccggag ttcccaacgg gttcaccatt cacctgggcg
    20341 ccgcgttccc atgaccagcc gtacggcttt ttctttctct gcggccagcg cggtccgtac
    20401 cgtctaggct cgacgccgca gacggtccgg accgctgcac agacttgcgt ccggatgggt
    20461 gcatgccgac tccgcagcgc attctcggcg tcggctgcaa ccgcggtgtc agcccttgtg
    20521 atcgtgcggc gcgctggctt ccctatgagc cttggacact tccttgcgga tgaacgcgag
    20581 cagttctgcg gacagccccg cttctgcgcc accgcgggca gcgatggcgg caacctggct
    20641 tctgagtacc aaggtttccg cgatcactcg ctcgacaccg gcatcatcgg acttgaacat
    20701 caaaggggtg gtgtccagag cctctgcaag ggccctgagg acttcgtcgg gcgcactcgc
    20761 caccacgccg gtcctcaggt cgtgcaccag gtcttccgtg aggacctctg ccccgacgag
    20821 gtcgtttcct cgtgcggcga gggcggcgtc ggtgaccggg gccggcatcc ggtccagcag
    20881 gtaggcgatc ttccccgcga gcgtggccgg cagcaccccg ctcccggtct cggccgaggt
    20941 tgtctgtgcg gacgacgact cgcctggctc gggcacatca tgcccgaagg aacgctcctg
    21001 cgctcgcctc agcgcatcca cgctcacacc gtaggcgtcg gccaggcgtt gttcgtactc
    21061 cttgctcagc cgccgctgcc cattctcggc ggcggcgacc ggccccggcg tccgcgtccc
    21121 ggtcaacgcc cgggtcgcgc tctgggaata gccggcatcg gcccggaggt cggcaagatc
    21181 cggccgcccg tttcggggga acagctggtc aaggtcacgc cggaccgccg cggccaaacg
    21241 cggcagcttc tcgggatcgg gcaccgaccg gcccgtctcc caagcgctga cgcgagcagc
    21301 actgacaccg acttcttccg ccacatcgct ctgcttgcgg ttctcatccc ggcgcgcgag
    21361 caagagggcc tgggcgtcga acagccgggc cggcatccaa cacgtccttc ctcgtccgac
    21421 gaggtgcgat cacttctggc cacttgatca atgagctgaa cgaggatact ttcgttccac
    21481 cgatcaaggt gagctgccag cttacctccg gccgggccgc tgcgcccgca ctcaggcgaa
    21541 acgtcactgc tacaccccac cgagagatca ccgcatgcac gccagtcgct agcgccctgc
    21601 gctgcacgac ttctacagag tttaagaacc aactctggat cttgacaccg gtccatgcgt
    21661 atgttcgtcg tcccccgggc agcccgcccg ggccccgcga tcgtgaggag cgcggcagga
    21721 accgacgaac tcgcgcaggt ccgcatacag cgacggcgcc caggagcggc tactccagga
    21781 cgccgaacgc atagcggcac gtaccgcccc gagcagggcc cggctaggcc cagcgggggc
    21841 ggagattgcc caccatcacc acgctggtcc ctttccacgg ggcgcgccag cgtggcaaca
    21901 ctgcaaaggg gattgttaca tgcctcccgc cctgcgcaaa aggccaagcc gtctggcctg
    21961 cgcggcaccc accctagctc cggccactcg ccgccccgac gcaccgcacg ccaccccggc
    22021 gtccgcgcag ggcctgccaa acgccggggc cgggggtggc cgatgagcag cgacgcccgc
    22081 gagtgggtat gggaacacag ttccagccgg ggtaccgcgc ggctggtcct gctgtcgatc
    22141 gccgaccggg tcgccgacga caagtgcgtc gcctgggcct cgctgacgag tctggtagag
    22201 cgtacgcgcg cgagccggac agcagtacgg gacgccctga ccgcgctcga caagagcggc
    22261 gagctgaagg tcctgagcca cctggagggc ccccagcgca gcaccgtcta ccggctgccc
    22321 cgggctgccg cgtggctggc caaggtcgcc gcagcccgac gggcggcccc ggacgcgtac
    22381 gtcgagccgc cggccgactc cgacccggtg ccggagctga acgaggaggc ccagaaggac
    22441 ctgcggcggt acgggatctg gcccaagaag ggtacggaac ccgccccctc ccaacggaat
    22501 ccgaccggta cggaatccgg cccctcccga cggaatccga cccctcgacg tgccggaatc
    22561 cgaccccagc acggtacgga atccggcccc cagaaccgta gagaacctaa gttgaaccgg
    22621 aaaggcagca gtagtggtgc tgccgtcacc tcggctgccg actggcaggt cgaccccgcc
    22681 agccacacct gggcccgcca acaaggccac ctcgaccgcc tcggcgagga cggcctgcga
    22741 gcggcggatg cgaagtggcg cgcccaccgt gccgggcacg caccccgacc agcggaggcc
    22801 tgggctgccg actggcgagc ctgggtcgcc cgagagcacg ctcccagccg cccgaacccc
    22861 tacgccctgc ccggtggtgg gtccgccccg gcgggcggca tgacccgctc cgaagcccac
    22921 accgccgccc tcctcgccgc cctcaacgag ccgacgccgg ccggaacgga gtagccatgg
    22981 accgccgcga aatcgccgcc ctgctggcct acatcggccg actcgacccc cgcaccatcc
    23041 gcaccgacca cgccgaggcc cgcgaccaga tcgcccagtg gcacgagctg ctggaggaag
    23101 tgccgctggc cacgccgcac ggctgggacg cctgcgtcgt cgcccgccgc cacatccgcc
    23161 tctcggcgta ccagatcctg cccgcggaca tcgcccgccc gtgggagagc tacaagcgcg
    23221 accgcctgca ccggcacacc gacccgaccc cggcggccga ccccgacgac caggcggcct
    23281 ggacggccga gctggtcggc acccgccgcg ccgtcgccac cggcaccgcc cagcccgtgc
    23341 agtaccggca actcgccgga agccgggtaa acccgaggct ggaagcacgg ctggagcaag
    23401 tcggctcctg catcccgccg gaggcccgcg ccgccctcgc gcccttccgc cgcgcccgcg
    23461 cggcccgcga agcggccctc gcccaggggc agccggacgc cctgtcggtg cgctgcgact
    23521 ggtgccaggc accggccgac gagccgtgcc gccgccgtcg catcggcccc gacggcttcg
    23581 cccgcggcag cgcggtgcgg gacgagccgc acccctgccg caaggacctc gccgccacac
    23641 agcagggcca gcagacggcc atggcctgac cggcccgccc gtggtgcacc cacacctggt
    23701 gcacccgcac aacaccatcg tcccgccgta ctgcggcacc cctgcccggt gccgcagcag
    23761 gcgcccgacg ccgcgtccat ccctccgaca ggccgacgcg gcagcacacc ggagaccttc
    23821 ttgcgccaca tcaccaccaa cacctcgccg gccaccggcc tgcgcggcat cggcgacacc
    23881 agctggcagc cccacggggt gtgccacggc atggaccccg aggacgccga cgccaccttc
    23941 ttccccctcc cccgggacca cgaagccatc gccgacgcca aggaactctg cgccttgtgc
    24001 cccgtacgcc gcgactgcct caactacgcc ttggagaacc aactcaagga gggcatctgg
    24061 ggcgggctga cggaggccga gcgccgcccc tggcacgacg gcctgccccg ccgcctcgac
    24121 tacagccgcg tggtcgcctt cttcaacggc cgcgacgtcc acctcaccga cgccgagcgc
    24181 caggtggtca tcgaccacgc ctacgtctgc ggatggcgcc ccgaccggct cgcccccgcc
    24241 ctgcagatca gcaccaagca cgcccgggac ctgctgcggc aggccgccaa caaggtcttc
    24301 gaccgcgacc gcgccctcgg cgtaccccgg cggaagaaca tcaccaagaa gaagaccatg
    24361 gtggccaggc ggacccggcc cgcgaccgta ccgcccgcca cgcagcagcc cctgacccgc
    24421 ccggcgacgc cgaccccggc gcacgcccct gtcggaaagg ccgcatgacc cagcccgtcc
    24481 tgtccctcgg tgctggcacc gacccgtccc tcctcctcac cctcggcatc cccggcgccg
    24541 ccaccgccct ggccctgacc ggctgggcac tgcggcgggc aaagcgctcg cagaaacgtc
    24601 ccgccagcgg ggcagtggtg gccgccgccc tagccgcgct cggctgcacc gcctacagcg
    24661 ccgacacgtc ctggcgcttc gccgccgact acctggacgt agccggtacc gccgagcgcg
    24721 ccagcatgtt cgccgccgcg gaactcggcc tgttcgcgac cgcactgatg gctcggcaga
    24781 atctgaccac gcagggcacg cccggggtgc cgggcaccct ggtctgggtc atcagcggcg
    24841 tgcaggtgat ccccgcctat gccgagagcg gggtcgtcgg cggcaccgtc cgggccttcg
    24901 tcggtccggt catggccggc atgctctggc atctggcgat gggtatcgag ctgcgtctgc
    24961 ggacccccgg agccgcctcc aagggcctgg tcgcctccct cgggcgcgaa gcacgcgaac
    25021 ggctgctgtc ccgtctcggc atcgccgccc gggaccgcga cgcggcacag atcacccggg
    25081 accgtgccac cacccgcgcc gtggacctcg ccacccggct cgccgaactc accaccgagc
    25141 ag
//
