LOCUS       NZ_AP024135            20633 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1000747
            Orig. end                         :: 1021380
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20633
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20633
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20633
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10633](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10633)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    214..229
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.73"
                     /tool="antismash"
     misc_feature    complement(217..232)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.67"
                     /tool="antismash"
     gene            298..1299
                     /locus_tag="K6K39_RS04065"
                     /old_locus_tag="EASAB2608_00860"
     CDS             298..1299
                     /NRPS_PKS="Domain: PKS_ER (21-329). E-value: 8.1e-44.
                     Score: 141.9. Matches aSDomain:
                     nrpspksdomains_K6K39_RS04065_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655666.1"
                     /locus_tag="K6K39_RS04065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00860"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_094372483.1"
                     /sec_met_domain="ADH_N (E-value: 8.6e-10, bitscore: 37.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.2e-20, bitscore:
                     71.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTVRFHQTGGPEVLLLEDLEPGEPGPGEVLLRIEAIGVNRADG
                     LFRSGRYIEPVKQFPARLGTEAAGVVEAVGPEVTGFAPGQPVSVVPGFSPNDYGVYAER
                     ALVPASALLPRSPEVDPVSGAAVWMPYLTAYGALVEVTGVRAGDVAVVNAASSSLGLAA
                     VQTANRLGATPVAVTRTRAKRQRLLDDGAAEVIVSAEEDVAGRVLELTGGRGAEHVFDA
                     VAGPGVRELARAVAPGGTLLLWGMQSGEPTPFPGFDLGMPALNMRTYTVTREVLAVPER
                     MRRAVAFVDSGLRTGALRPVVDRTFPLADVVQAHRYMEEGTQYGKIVLTVGR"
     aSDomain        361..1284
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K6K39_RS04065_PKS_ER.1"
                     /evalue="8.10E-44"
                     /label="K6K39_RS04065_PKS_ER.1"
                     /locus_tag="K6K39_RS04065"
                     /protein_end="329"
                     /protein_start="21"
                     /score="141.9"
                     /tool="antismash"
                     /translation="EPGEPGPGEVLLRIEAIGVNRADGLFRSGRYIEPVKQFPARLGTE
                     AAGVVEAVGPEVTGFAPGQPVSVVPGFSPNDYGVYAERALVPASALLPRSPEVDPVSGA
                     AVWMPYLTAYGALVEVTGVRAGDVAVVNAASSSLGLAAVQTANRLGATPVAVTRTRAKR
                     QRLLDDGAAEVIVSAEEDVAGRVLELTGGRGAEHVFDAVAGPGVRELARAVAPGGTLLL
                     WGMQSGEPTPFPGFDLGMPALNMRTYTVTREVLAVPERMRRAVAFVDSGLRTGALRPVV
                     DRTFPLADVVQAHRYMEEGTQYGKIVL"
     CDS_motif       484..522
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS04065_0001"
                     /evalue="1.90E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="K6K39_RS04065"
                     /protein_end="75"
                     /protein_start="62"
                     /score="11.2"
                     /tool="antismash"
                     /translation="LGTEAAGVVEAVG"
     CDS_motif       901..921
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K6K39_RS04065_0002"
                     /evalue="9.90E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="K6K39_RS04065"
                     /protein_end="208"
                     /protein_start="201"
                     /score="-3.0"
                     /tool="antismash"
                     /translation="DVAGRVL"
     gene            1368..2522
                     /locus_tag="K6K39_RS04070"
                     /old_locus_tag="EASAB2608_00861"
     CDS             1368..2522
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015837 - amine transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964372.1"
                     /locus_tag="K6K39_RS04070"
                     /note="Members of the family are the ATP-binding subunit of
                     ABC transporters for substrates such as betaine, L-proline
                     or other amino acids, choline, carnitine, etc. The
                     substrate specificity is best determined from the
                     substrate-binding subunit, rather than this subunit, as it
                     interacts with the permease subunit and not with substrate
                     directly; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00861"
                     /product="betaine/proline/choline family ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_086700417.1"
                     /transl_table=11
                     /translation="MIRFEQVTKRYPDGTTAVDDLSFEVSEGELVTLVGPSGCGKTTTM
                     MMVNRLIEPTSGRILVGGEDIAGVDPVRLRRRIGYVIQQVGLFPHRTVLDNTATVPALL
                     GWKRAKARARAAELLDLVGLDPATYGPRYPEQLSGGQRQRVGVARALAADPPVLLMDEP
                     FGAVDPVVREQLQDEFLRMQAAVRKTVLLVTHDIEEAVRLGDRIAVYGQGRIEQFDTPG
                     AVLGAPATPYVAGFVGADRGLKRLSVTAIEPDDLEQPPVARPDESARRALERLRAEGAR
                     WAVVLDPGGDLRGWVGVEELAAGGTVGDRTHRMTAWVPVGAPLKQAFGVMLQYDAGWVA
                     VLDGARFLGVLTPAKLHEALRRSVDADARGVTRGQVPFDSVADA"
     gene            complement(2529..3470)
                     /locus_tag="K6K39_RS04075"
                     /old_locus_tag="EASAB2608_00862"
     CDS             complement(2529..3470)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548595.1"
                     /locus_tag="K6K39_RS04075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00862"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_086700432.1"
                     /transl_table=11
                     /translation="MKGRTALAALTLLALGGCATGPSLENRGQVTAPPGDSRTLTVGSA
                     GFTESDLLAQMYALLLNQAGHRTSLLTVANRELYEPALESGQIDVVPEYAATFADWLNA
                     KTHGADAKAVGSPDLGATMRALRALAAPRGLTVLPPGRAVDQNAFAVTAAYARRHRLKT
                     LSDLGASGLKVRLAAGDECVRRPYCAPGLRKVYGIDITGVDPKGVGTTQAKRAVQEGRD
                     QMVLTTTTDATLDSFGLVLLADDKRLQNADHVVPVVNRARAGGPGVAKALGRLNDVLTT
                     GDLAAMNRQVDSWRRLPADVARAYLKDKGLLK"
     gene            complement(3467..4138)
                     /locus_tag="K6K39_RS04080"
                     /old_locus_tag="EASAB2608_00863"
     CDS             complement(3467..4138)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676574.1"
                     /locus_tag="K6K39_RS04080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00863"
                     /product="ABC transporter permease"
                     /protein_id="WP_059246732.1"
                     /transl_table=11
                     /translation="MSTLAAAWDWLADPAHWSGDDGIRHRLLQHLVLTVVCLLLSCLIA
                     LPVALVLGHLGKGGALAVNLSNIGRAVPTFAVLVLLLLTPVGRWGEGPTVVALVLFAVP
                     PLLTNAYVGMREVDRGVVRAARGMGMTGRQLLFRVELPLSLPLLLNGVRIAAVQLVATA
                     TLAALAGGGGLGRIITAGFNLASTPQVVAGALLVAGFALVVEGVFETAERLAPAWARGG
                     R"
     gene            complement(4135..4815)
                     /locus_tag="K6K39_RS04085"
                     /old_locus_tag="EASAB2608_00864"
     CDS             complement(4135..4815)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676573.1"
                     /locus_tag="K6K39_RS04085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00864"
                     /product="ABC transporter permease"
                     /protein_id="WP_059246731.1"
                     /transl_table=11
                     /translation="MTAPPDDCLARNEWICGAYLSSRRQILLDALVQHVQLTFLSVLIG
                     LVVAVPLAVLARRWSWAAGPVLAVTTVLYTIPSLAMFSLLLPLYGLSAGLVVAGLVLYS
                     LTLLVRNILAGLRAVPEETRQAARGLGYGPVRLLLTVELPLALPAAMAGLRIATVSAVS
                     LVTVGAIVGFGGLGNLIYAGMNTYFKAQVLTASVLCVLIAVAADLLLLGAQRLITPWTR
                     AARA"
     gene            complement(5390..5962)
                     /locus_tag="K6K39_RS04090"
                     /old_locus_tag="EASAB2608_00867"
     CDS             complement(5390..5962)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068449.1"
                     /locus_tag="K6K39_RS04090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00867"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_059246730.1"
                     /transl_table=11
                     /translation="MVSTDKASPCDRLLDAAARLSYRDGVSIGVETLCREAGVSKRSMY
                     QLFDSKDQMLAASLERRVARYQARLAHPDPDAATPRERILYVFEQLEKGSVDPDYHGCP
                     YLAVLVELKDPEHPASAVARGVKQTLKEAFRTEAERGGARDPELLARQLLLIFDGASAR
                     AGARVERLDDGLATATATALLDAAGLA"
     gene            6088..6945
                     /locus_tag="K6K39_RS04095"
                     /old_locus_tag="EASAB2608_00868"
     CDS             6088..6945
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676571.1"
                     /locus_tag="K6K39_RS04095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00868"
                     /product="MoxR family ATPase"
                     /protein_id="WP_059246729.1"
                     /transl_table=11
                     /translation="MFTSVDDVSARLAETGYLASPAVATTVFLAARLGKPLLVEGPAGV
                     GKTELAKAVAQVAGARLVRLQCYEGVDESRALYEWNHAKQLLRISAGRGESWDETRTDI
                     FSEEFLLPRPLLTAIRGDEPTVLLIDETDKADVEMEGLLLEVLSDFQVTVPELGTVTAT
                     RRPFVVLTSNAGRELSEALRRRCLFLHIGFPEEELERRIVRLKVPGLGDALTESVVRVV
                     GALRAMDLRKAPSVAETVDWARTLLALGAGTLDETVVRDTLGVILKHQDDIQKAAAKLD
                     LDAL"
     gene            6942..8294
                     /locus_tag="K6K39_RS04100"
                     /old_locus_tag="EASAB2608_00869"
     CDS             6942..8294
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676570.1"
                     /locus_tag="K6K39_RS04100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00869"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_059246728.1"
                     /transl_table=11
                     /translation="MTAVADRITGLAAALRAHGVRIGTGETVDAARAVAALGLADRERL
                     REGLAATLLHGPGQRALFDSVFDLYFPRGVGGPEDAHRDRETLRDRLADALAADDRALL
                     ARLAAEAVDGLGGYGGAPGSDGFSAYQTLERLRPQTLLARVRAEVRGRGGDGGGFADRL
                     LDDEIRRRIEEFRRMVGAEARRRVAERRGRDEIARRAVRPTADRVDFLYANREQLAELR
                     RAVQPLARKLATRLAARRRRAARGTIDLRRTLRSSLSTGGVPMRPVLRRRRPVRPELVL
                     LCDVSGSVSGFSDFTMLLVQALHDQFGKVRVFAFVNRLDEVTGLLDHGRADPDGLGARI
                     RAEATLTGWHGSSDYGMALGEFAERYGAAVGPRTTVFVLGDARTNLSDPNLPAVRELAR
                     RARRVYWLNPEPRDRWGTGDSAAPAYAELVEMHECRTARQLSGLIAGLLPV"
     gene            8357..9331
                     /locus_tag="K6K39_RS04105"
                     /old_locus_tag="EASAB2608_00870"
     CDS             8357..9331
                     /EC_number="4.4.1.-"
                     /GO_function="GO:0016846 - carbon-sulfur lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676569.1"
                     /locus_tag="K6K39_RS04105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00870"
                     /product="D-cysteine desulfhydrase family protein"
                     /protein_id="WP_221333992.1"
                     /sec_met_domain="PALP (E-value: 6.8e-45, bitscore: 152.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHPPVPLGTFPTPLEPAPRLAAALGLGPDDLWVKRDDLTGLGGG
                     GNKIRKLEWAVGAALAEGADTLVTTGAPQSNHARLTAAAGARLGLRVVLVLRGAPGASR
                     SGNLALDGLFGARLAWAGAVDRAGLDAAAAEVCARLRAGGARPALIPFGGSSVLGARGY
                     LRCGAELREQLPDLRTAVVALGSGGTMAGLVAALGSASVLGVDVGALADPAAAVAEFAT
                     PLTTEEVAPEELRIRRDQVGAGYAALTGPVREALRLAARTEGLALDPTYTGRALAGLHA
                     AVRDGGIRPGEKTVFLHTGGLPGLFGHPDALAFAEEGATVLDG"
     gene            complement(9482..9841)
                     /locus_tag="K6K39_RS04110"
                     /old_locus_tag="EASAB2608_00871"
     CDS             complement(9482..9841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386516.1"
                     /locus_tag="K6K39_RS04110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00871"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_059246726.1"
                     /transl_table=11
                     /translation="MLEVKTVEKPDERRDFPRGHLEALHLTGLDFAVGTFEPGWRWSES
                     VAPIAGTESCQVHHNGYVVQGRLHIRMDDGGEGEVGPGDVFVCPPGHDAWVVGDEQVVV
                     HDFAGAMAKEYAKGQ"
     gene            complement(10001..10633)
                     /locus_tag="K6K39_RS04115"
                     /old_locus_tag="EASAB2608_00872"
     CDS             complement(10001..10633)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_Pyr4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952725.1"
                     /locus_tag="K6K39_RS04115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00872"
                     /product="hypothetical protein"
                     /protein_id="WP_223283697.1"
                     /sec_met_domain="TS_Pyr4 (E-value: 1.3e-29, bitscore:
                     102.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAVHTVFLLGTGVFWTAAYVLLVRTGLREHTYGMPVVAFATNIS
                     WEFMFAFVRPPSGVMHVVDIVWFCFDLAIGYTVVRYGRSEFPYLPRRLYLPALAALLLL
                     AYPGMQVASEQFDEGGGTITAFGSNLAMSAMFLAMLAARRGPRGQSTGIALAKLLGTAC
                     ASLAMLTTADPAPRHDSALMRYFYVGCFLLDLVYLAALRAVRRAVPR"
     gene            10687..11289
                     /locus_tag="K6K39_RS04120"
                     /old_locus_tag="EASAB2608_00873"
     CDS             10687..11289
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676567.1"
                     /locus_tag="K6K39_RS04120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00873"
                     /product="HD domain-containing protein"
                     /protein_id="WP_059246725.1"
                     /transl_table=11
                     /translation="MTASDTPSIAMDDTGDPPLRPLPERAASLLARVDAPPRLVAHLRA
                     VHDVAAQLVAWVQRHCPRLESDAEAVLFGAATHDIGKALHPAELSGPGARHEAAGRELL
                     LTHGVEARLARFAGTHASWTAPGIGVEDLLVSLADKVWKNKRVPELEDLVVARLAGADG
                     RPAWQWFMELDETLTAIGEGADRRLAYQMSHPLTRPQ"
     gene            11382..11948
                     /locus_tag="K6K39_RS04125"
                     /old_locus_tag="EASAB2608_00874"
     CDS             11382..11948
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236020.1"
                     /locus_tag="K6K39_RS04125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00874"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_059246724.1"
                     /transl_table=11
                     /translation="MFATSLGADGAELCPLQPWQAEEFLAHVDRGREFIGRFNGLPDVV
                     ADLASSRAFLEAYAAKEAADAGLIRAIRLDGTLVGAVILRRMDVPQGTAEAGCWLEPAA
                     VGRGLVTRAARLLIDWAIRERGIHRVEWWVSAGNAPSIAVARRLGMRKEAVLRESHLYR
                     GERHDEEIWAVLAPEWPAVPGATAA"
     gene            complement(11967..12911)
                     /locus_tag="K6K39_RS04130"
                     /old_locus_tag="EASAB2608_00875"
     CDS             complement(11967..12911)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128677.1"
                     /locus_tag="K6K39_RS04130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00875"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_086700429.1"
                     /transl_table=11
                     /translation="METASLDLNLLRTFLAVYRSGSFTGAARLLGLSQPTVTTQMRALE
                     RQTGRELFERLPRGVAPTPVADELAARIAAPLDELAAVAGPTPPAGTGAEPVHLAGPAE
                     LLCTKALPALAPLVAEGVRLRVATGLTDPLLEELRAGRHDLVIATTRPRGRTLQAVALT
                     DEEFVLVAAPVWAERLTGRRGAQGSEARPAAAQGGLDPAVLHGVPLVTYAEDLPIARRY
                     WRHVFGRRLSRTAAVTVPDLRGVLAAVVAGAGFSVLPRYLCQDLLDSGALVALLEPEDP
                     PINTGFLVQRPGASDNPDVARVRALLLRAARDW"
     misc_feature    complement(13126..13139)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.25"
                     /tool="antismash"
     gene            13667..14347
                     /locus_tag="K6K39_RS04140"
     CDS             13667..14347
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676562.1"
                     /locus_tag="K6K39_RS04140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_059246721.1"
                     /transl_table=11
                     /translation="MTTATPLATALPWERAGTRKPPASWRRRAAALRHRVLARTRTGTT
                     PAAPGTEPGTGTRPAVDTGPPQGIEELYHHRRLSLVRLAVLLVDDLPTAEDVVQDAFTA
                     LFRRHGHRLAALDDPEAYLRTSVVNAARSVLRRRRTVRAHTPAPEGHAPAPEEDVLLHE
                     DHREVLAALRTLTRRQREVLVLRYWSHLTEAEIAATLGLSRGAVKSTASRALDALGRRL
                     EGLR"
     gene            14344..14691
                     /locus_tag="K6K39_RS04145"
                     /old_locus_tag="EASAB2608_00877"
     CDS             14344..14691
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676561.1"
                     /locus_tag="K6K39_RS04145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00877"
                     /product="hypothetical protein"
                     /protein_id="WP_059246720.1"
                     /transl_table=11
                     /translation="MNESGTGITATPVEERLRAALAARADSVGPADLRPLRPPAGAVRS
                     RRVLVRRVVAGVLVLAAAAVLVFFSVRGGPPAPRPAEPARSPHPPTGTPSPVPSPVSPS
                     TARPSPSAPQR"
     gene            <15052..>15153
                     /locus_tag="K6K39_RS04150"
                     /pseudo=""
     CDS             15052..>15153
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558197.1"
                     /locus_tag="K6K39_RS04150"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSRGGLTIKIHLAAVSRCRPLAFVVTPGPAGEA"
     gene            complement(15239..15481)
                     /locus_tag="K6K39_RS04155"
                     /old_locus_tag="EASAB2608_00878"
     CDS             complement(15239..15481)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971382.1"
                     /locus_tag="K6K39_RS04155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00878"
                     /product="DUF5133 domain-containing protein"
                     /protein_id="WP_059246719.1"
                     /transl_table=11
                     /translation="MPLPTEKELREVLARFAQARIAHDVHPTGSTSMNLEDAVDTLCVM
                     TGARTIEQALLTADTLLEEHTGRTHAPQEDETLAA"
     gene            complement(15516..15860)
                     /locus_tag="K6K39_RS04160"
                     /old_locus_tag="EASAB2608_00879"
     CDS             complement(15516..15860)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031884.1"
                     /locus_tag="K6K39_RS04160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00879"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_059254688.1"
                     /transl_table=11
                     /translation="MRGAPLRIHDQAAVVQFEYGDAWVVSARGSYDMYSITPLAEALDT
                     AAEAHRKVVLDASGITFGDSTLLNLLILTHHKADLRVAAPTQQVRRLLEITGADTLLKV
                     RATVAEAAAC"
     misc_feature    15885..15901
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.97"
                     /tool="antismash"
     misc_feature    complement(15949..15960)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     gene            16004..16366
                     /locus_tag="K6K39_RS04165"
                     /old_locus_tag="EASAB2608_00880"
     CDS             16004..16366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004082.1"
                     /locus_tag="K6K39_RS04165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00880"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_059254687.1"
                     /transl_table=11
                     /translation="MVAVPGSHTGWTFITNHARVLAAIADNPNIRIRDIAAHCRLTERA
                     VQRIISDLEQDGYLSHTREGRANTYRIDPDKVLRHPAEAGLTVAALLSLLVRDETDRMG
                     KPGSQSPRLAGAGGAS"
     gene            16827..17264
                     /locus_tag="K6K39_RS04170"
                     /old_locus_tag="EASAB2608_00882"
     CDS             16827..17264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007830042.1"
                     /locus_tag="K6K39_RS04170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00882"
                     /product="ATP-binding protein"
                     /protein_id="WP_059246718.1"
                     /transl_table=11
                     /translation="MADDSSMRAVGWARSLPISAGVREARNWTRSHMTALGWDRTAPAL
                     VDAVVLAVSELVTNAHVHAHSAAQLILTWDEECLHVTVHDASPRLPEQRRTDHDALGGR
                     GLLLVDALADDWQIRRCPRGKDVTACFQPPASEEGRAREAE"
     misc_feature    16869..16882
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(17348..18139)
                     /locus_tag="K6K39_RS04175"
                     /old_locus_tag="EASAB2608_00883"
     CDS             complement(17348..18139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981524.1"
                     /locus_tag="K6K39_RS04175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00883"
                     /product="hypothetical protein"
                     /protein_id="WP_059246717.1"
                     /transl_table=11
                     /translation="MTAQPARPGRSGPRTASVMDVPPFKPSLVKAVFRDVTSLHVSRSA
                     AWAAASVTRTVLTEIIDGARRAAAEEARKKLIPGDLLSAIDRNAELEVGTKWYDHSPTF
                     RGLTGVLYDAAGVLVPSRKRSGSRKPSAVVGAHRFEAGVRKLLRSQGVTAVPAMVRDLD
                     GIASAFLTDLARDAAMVVREGGVTRFGTVTLVMPGEPAPPPFPGDSHRALSRRKGDGRT
                     IGSDDVLAATTIQLFGGNLRQRALTEAREVPGRAGGSRSRR"
     gene            complement(18249..18677)
                     /locus_tag="K6K39_RS04180"
                     /old_locus_tag="EASAB2608_00884"
     CDS             complement(18249..18677)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013625.5"
                     /locus_tag="K6K39_RS04180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00884"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_059246716.1"
                     /transl_table=11
                     /translation="MLTSRTSRDRGRTRAGTWIGTFTVAALAAFTLTAAPARASTAPPA
                     PPSLPAPAAAPSDGRALWCGYYSGTAPVSRGDSGNEVREVQCLLRRCGYDVPVDGLFGA
                     GLEAVVKRFQRDHGLAPDGTVGPGTWQALRKCGTTAAA"
     gene            complement(18697..19749)
                     /locus_tag="K6K39_RS04185"
                     /old_locus_tag="EASAB2608_00885"
     CDS             complement(18697..19749)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013625.5"
                     /locus_tag="K6K39_RS04185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00885"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_079080796.1"
                     /transl_table=11
                     /translation="MAPQLVTRAAWGARAPKKVSHDIRPGDGGVAVHHIGETPLALAGH
                     AQCASLVRSVQNTHMNGEYDDIAYSFLACPHGYVFEGRGYGVRTGANGTKDANDRFYAV
                     CALTGGTPGRYDPVTTGLVEAIRTAIAGLRSLGGAGARIVGHRDLTATECPGALYAYVR
                     DGRFEPGTAPGPGGEEPPPPGQEVPWPGVLLQYPPVTVHWSARTWQEQMRRRGWTIDVD
                     GAYGEQSRRVCLAFQREKSLTVDGVVGRDTWQASWRAPVTAPADGDSSHRDAPPWPGVL
                     FTYPPFTRHPGVATWQARMRERGWSLDADGVYGSRSRQVCLAFQKEKRLTADGIVGPAT
                     WQAAWAAPVT"
     gene            complement(19749..20000)
                     /locus_tag="K6K39_RS04190"
                     /old_locus_tag="EASAB2608_00886"
     CDS             complement(19749..20000)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS04190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_00886"
                     /product="hypothetical protein"
                     /protein_id="WP_059246715.1"
                     /transl_table=11
                     /translation="MHLTRRHVLLTAFSAAAATALSLSGAGSAAAAAASPAGLGTRDML
                     SPTDPDAIIPVISDHWYAEGVSREPLNGWVQCTGGGER"
     gene            complement(20082..20450)
                     /locus_tag="K6K39_RS04195"
                     /old_locus_tag="EASAB2608_00887"
     CDS             complement(20082..20450)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013625.5"
                     /locus_tag="K6K39_RS04195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00887"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_059246714.1"
                     /transl_table=11
                     /translation="MTKTLRGLVPAALAGALLLGGAASAMAAPAAPAPASDKQVAAAAV
                     SCGYHSGTRYADRGDRGAHVKEIQCLLRDVWGYSIGSSGIDGIFGAATERAVKAFQADH
                     PLAADGKAGPNTWRALRG"
     misc_feature    20619..20633
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.04"
                     /tool="antismash"
ORIGIN
        1 ggaccaccac atctgcgtcg tccgcgtccc ggaccaggtc gtctcctcgg tcccgcaggc
       61 cctggaacgc ctcgatccgg cccgcccgtc gacctggatc tcgggtccgt cggccaccag
      121 cgacatcgaa ctggaccggg tggagggcgt gcacgggccc cgcaccctgg aggtgatcct
      181 gctcggctga gcctctttcc ccggcacagt tggtacgaga atcatcgtag tttgacagtc
      241 atcgaacttt gtcgcagagt ggtccgcgaa caccactgac gacaaggggg agttggcatg
      301 gcgacgacgg tacggttcca ccagaccggc gggcccgagg tgctgctgct ggaggatctg
      361 gagccgggtg agccgggtcc cggcgaggtg ctgctgcgca tcgaggcgat cggcgtgaac
      421 cgggccgacg ggctgttccg cagcggacgg tacatcgaac cggtcaagca gttcccggcc
      481 cggctcggca ccgaggcggc gggcgtggtg gaggccgtcg gccccgaggt gaccgggttc
      541 gcgcccgggc agcccgtcag tgtggtcccg ggcttctccc ccaacgacta cggcgtgtac
      601 gccgaacgcg cgctcgtccc cgcgtccgcg ctgctccccc gctcccccga ggtggacccg
      661 gtcagcgggg cggcggtgtg gatgccgtac ctgacggcgt acggggcact ggtggaggtc
      721 accggggtcc gggccggcga cgtggccgtg gtgaacgcgg cctccagcag tctcggtctg
      781 gccgccgtcc agacggcgaa ccggctcggc gccacgcccg tcgccgtcac ccggacccgc
      841 gccaagcggc agcggctgct ggacgacggc gccgccgagg tgatcgtctc cgccgaggag
      901 gacgtggccg ggagggtgct ggagctgacc ggcggccggg gcgccgagca cgtcttcgac
      961 gccgtcgccg gaccgggcgt gcgggagctg gcccgggcgg tggcccccgg cgggacgctg
     1021 ctgctgtggg ggatgcagag cggcgagccc actccgttcc ccggattcga cctcggcatg
     1081 cccgcgctga acatgcgcac ctacaccgtg acccgcgagg tcctggcggt ccccgagcgg
     1141 atgcggcgtg ccgtcgcctt cgtcgactcg ggcctgcgca ccggcgccct gcgcccggtg
     1201 gtcgaccgca ccttcccgct ggcggacgtc gtccaggccc accggtacat ggaggaggga
     1261 acgcagtacg gcaagatcgt gctgacggtc gggcggtgac gccccggcgt ccgccggtcg
     1321 gggcacggcg ggatgaggcc cgccgcccgc tgccgtagcg tgagggaatg atccggttcg
     1381 agcaggtcac caagcggtat ccggacggta cgacggcggt ggacgacctc tccttcgagg
     1441 tgtccgaggg ggaactggtc acgctcgtgg gaccgtccgg gtgcggcaag acgaccacca
     1501 tgatgatggt gaaccggctc atcgagccga cctccggccg catcctcgtc ggcggcgagg
     1561 acatcgccgg cgtcgacccg gtccggctgc gccgccggat cgggtacgtc atccagcagg
     1621 tgggcctctt cccgcaccgc accgtcctcg acaacaccgc gaccgtgccg gccctgctcg
     1681 gctggaagcg ggcgaaggcg cgggcgcggg cggccgagct gctggacctg gtgggtctcg
     1741 acccggcgac gtacgggccg cgctacccgg agcagctgtc cggcgggcag cggcagcggg
     1801 tcggggtggc gcgggcgctg gccgccgatc cgccggtgct gctgatggac gagccgttcg
     1861 gcgcggtcga cccggtggtg cgcgagcagt tgcaggacga gttcctgcgt atgcaggccg
     1921 cggtgcgcaa gacggtgctg ctggtcacgc acgacatcga ggaggccgtc cggctcggcg
     1981 accgcatcgc cgtgtacggg cagggccgca tcgagcagtt cgacacaccg ggcgcggtgc
     2041 tcggggcgcc cgcgacaccg tacgtcgccg gtttcgtggg cgccgaccgc gggctgaagc
     2101 ggctgtcggt caccgcgatc gagccggacg acctggaaca gccgccggtg gcccgcccgg
     2161 acgagtccgc gcgccgggcg ctggagcggc tgcgggccga gggcgcccgc tgggccgtgg
     2221 tcctggaccc gggcggtgac ctgcgcggct gggtcggcgt cgaggagctg gcggcgggcg
     2281 gcacggtcgg cgaccgcacc caccggatga ccgcctgggt gccggtcggc gcaccgctga
     2341 agcaggcgtt cggggtgatg ctccagtacg acgccgggtg ggtcgcggtg ctcgacgggg
     2401 cgcggttcct cggtgtcctg accccggcga agctgcacga ggcgctgcgc cgctcggtgg
     2461 acgcggacgc gcgcggggtg acccggggtc aggtgccgtt cgactcggtg gcggacgcct
     2521 gaccggggtc atttcagcag gcccttgtcc ttgaggtagg cgcgggcgac gtcggccggc
     2581 agccggcgcc agctgtccac ctgccggttc atggcggcca ggtcgccggt ggtgaggacg
     2641 tcgttgagcc tgccgagggc cttcgccaca ccggggccgc ccgcccgggc gcggttgacg
     2701 accgggacga cgtggtcggc gttctgcagc cgcttgtcgt cggcgagcag gaccaggccg
     2761 aacgagtcga gggtggcgtc ggtggtggtg gtcaggacca tctggtcccg gccctcctgc
     2821 acggcccgct tggcctgggt ggtgccgacg cccttggggt cgacgccggt gatgtcgatg
     2881 ccgtacacct tccgcagtcc cggggcgcag tacggccgtc gcacgcattc gtcgcccgcc
     2941 gcgagccgta ccttcagtcc ggaggcgccg aggtcgctga gggtcttcag gcggtgccgg
     3001 cgggcgtagg cggcggtcac cgcgaaggcg ttctggtcga cggcccggcc gggcggcagg
     3061 acggtgaggc cgcggggggc ggcgagggcc cgcagcgcgc gcatcgtggc gccgaggtcg
     3121 ggcgagccga ccgccttcgc gtccgcaccg tgggtcttcg cgttgagcca gtcggcgaag
     3181 gtggccgcgt actcggggac gacgtcgatc tggccggact ccagggccgg ttcgtacagc
     3241 tcccggttgg cgaccgtgag gagggacgtc cggtggccgg cctggttcag cagcagggcg
     3301 tacatctggg cgagcaggtc gctctcggtg aagccggccg agccgacggt cagggtgcgg
     3361 ctgtcgccgg gcggtgcggt gacctggccg cggttctcca gggacgggcc ggtggcgcag
     3421 ccgcccagcg cgaggagcgt gagcgcggcc agcgccgtac ggcccttcat cggccgcccc
     3481 gggcccatgc cggtgccagc cgctcggcgg tctcgaagac cccttcgacg acgagggcga
     3541 acccggcgac gagcagcgcg cccgcgacca cctggggtgt gctggcgagg ttgaacccgg
     3601 ccgtgatgat ccggccgagg ccgccgccgc ccgcgagcgc ggcgagggtg gccgtggcga
     3661 cgagctggac ggcggcgatc cgcaccccgt tgagcagcag cggcagcgac aggggcagtt
     3721 ccacgcggaa cagcagctgc cggccggtca tccccatgcc ccgggcggcc cggacgacac
     3781 cgcggtcgac ctcgcgcatc cccacgtagg cgttggtgag cagcggcggt acggcgaaca
     3841 gcaccagagc gaccaccgtc ggcccctcgc cccaccgtcc gaccggggtc aacagcagca
     3901 ggaccaggac ggcgaaggtg gggacggccc ggccgatgtt ggagaggttc acggcgagcg
     3961 cgccgccctt gccgaggtga ccgaggacga gggcgacggg cagggcgatc agacagctca
     4021 ggagcaggca gacgacggtg agcaccaggt gctggagcag ccggtgccgg atgccgtcgt
     4081 cgcccgacca gtgcgcgggg tcggcgagcc agtcccaggc ggcggcgagg gtgctcatgc
     4141 gcgggccgcc cgcgtccagg gggtgatcag ccgctgcgcg cccagcagga gcaggtcggc
     4201 ggcgacggcg atcagcacgc acagcacgga cgcggtgagc acctgggcct tgaagtaggt
     4261 gttcatgccc gcgtagatga ggttgccgag gccgccgaag ccgacgatgg cgccgacggt
     4321 caccagggag accgccgaga cggtcgcgat gcgcaggccg gccatcgcgg cgggcagggc
     4381 gaggggcagc tcgacggtga ggagcaggcg gacggggccg tagccgaggc cgcgggccgc
     4441 ctgccgggtc tcctccggga ccgcgcgcag gcccgcgagg atgttccgga cgagcagggt
     4501 gagcgagtac agcaccagcc cggcgacgac caggccggcc gagaggccgt acaggggcag
     4561 gagcagggag aacatggcca gcgaggggat ggtgtagagg accgtcgtga cggcgagcac
     4621 cgggccggcc gcccagctcc agcggcgggc cagcaccgcc agcggcaccg cgacgaccag
     4681 gccgatcagg accgacagga aggtcagctg gacgtgctgg acgagcgcgt cgagcaggat
     4741 ctggcggcgg ctgctcagat aggcaccgca gatccattcg ttgcgcgcga ggcagtcgtc
     4801 cgggggcgcg gtcacggctc cattggaccg ggcggacggg gtcctcggcg cgttgtggtg
     4861 acccgtaagg gggcgcgcga cgacccgcag gggacacctg gcgctctgtg ccccgtgggg
     4921 gccgcgaggg gccggccgat gccccgtaaa gaggcacccg gcactcgatg acccgcaagg
     4981 cccgcggcga aggtccggcc gcccgcaacg gcacgggtca cccgatcatc cgggaagcac
     5041 ccggcacccg gtggcccgga aggcacccga ggcagccgat gacccgcaag ggccccgacg
     5101 cgcccggtga tccgcaaagg gacgtgaagc gttaggtggc cccctcagga cagtgacccg
     5161 caagagacgt gagacgttag gtggcccgct cagcacggcg ccccgcaaga gacctgaagg
     5221 cgctaggtgg cccgctcagc acggcgcccc gcaagagacc tgaaggcgct aggtggcccg
     5281 ctcagcacgg cgccccgcaa gagacctgaa ggcgctaggt ggcccgctca cgacgcacgg
     5341 ccccgcatag gacccatggc cctgggtggc cgcggggaag cgcgggccgc taggccagcc
     5401 ccgccgcgtc cagcagtgcc gtcgccgtcg ccgtggcgag tccgtcgtcc aggcgttcca
     5461 cccgggcgcc ggcgcgggcg ctggcgccgt cgaagatcag gaggagctgg cgggcgagca
     5521 gctcggggtc gcgggcgccg ccccgctccg cctccgtgcg gaaggcctcc ttcagggtct
     5581 gcttgacccc gcgggcgacg gcgctcgccg ggtgctcggg atccttcagc tcgaccagca
     5641 cggccaggta ggggcagccg tggtagtcgg ggtccacgga gcccttctcc agctgctcga
     5701 agacgtacag gatgcgctcg cgcggggtcg cggcgtcggg gtcggggtgc gccaagcggg
     5761 cctggtaccg cgcgacccgc cgctccaggc tcgcggccag catctggtcc ttgctgtcga
     5821 agagctggta catcgaccgc ttggagacac ccgcctcccg gcacagcgtc tcgacgccga
     5881 tggacacgcc gtcccggtag gagagccgcg cggcggcgtc gagcagccgg tcgcaggggg
     5941 acgccttgtc tgtactgacc ataccacgag gttaccgcgc ggcgaaaccg atcggtgtat
     6001 tccatggcgc ccaagctgaa caagcgctta gataggaaac ggatcacgat ctcaccggac
     6061 gctgtccccg acccgccgga ggccccgttg ttcacgtccg tcgacgacgt ctccgcccgc
     6121 ctcgccgaga ccggctatct cgcctcgccc gccgtcgcca cgaccgtctt cctcgccgcc
     6181 cggctcggca agccgctgct ggtggagggt cccgccgggg tcggcaagac ggaactggcc
     6241 aaggccgtcg cccaggtggc cggcgcccgg ctggtccggc tccagtgcta cgagggcgtg
     6301 gacgagtccc gggccctgta cgagtggaac cacgccaagc agctgctgcg catcagcgcg
     6361 ggccgcggcg agagctggga cgagacccgc accgatatct tcagcgagga gttcctcctc
     6421 ccccgcccgc tgctgaccgc catccgcggc gacgagccga cggtgctgct catcgacgag
     6481 acggacaagg ccgacgtcga gatggagggg ctgctgctgg aggtgctcag cgacttccag
     6541 gtcacggtgc cggagctggg caccgtcacc gcgacccgcc gcccgttcgt cgtcctcacc
     6601 tccaacgccg gccgcgagct gtccgaggcg ctgcgccgcc gctgcctgtt cctgcacatc
     6661 ggcttccccg aggaggagct ggagcggcgg atcgtacggc tgaaggtgcc cggcctcggc
     6721 gacgctctga ccgagtcggt ggtccgggtg gtcggggcgc tgcgcgcgat ggacctgcgc
     6781 aaggcgccgt ccgtcgccga gaccgtcgac tgggcgcgca ccctgctggc cctgggcgcc
     6841 ggcacgctgg acgagaccgt cgtacgggac accctcgggg tgatcctcaa gcaccaggac
     6901 gacatccaga aggcggcggc caagctcgac ctggacgcgc tgtgaccgcc gtcgccgacc
     6961 ggatcaccgg cctggccgcg gcgctgcgcg cgcacggggt gcggatcggc accggggaga
     7021 ccgtggacgc ggcccgcgcg gtggcggcgc tggggctcgc ggaccgggag cggctgcgcg
     7081 agggcctggc cgcgacgctg ctccacggac ccggccaacg cgccctgttc gactcggtct
     7141 tcgacctgta cttcccgcgc ggggtcggcg gcccggagga cgctcaccgg gaccgggaga
     7201 ccctgcgcga ccggctcgcg gacgcgctgg ccgccgacga ccgggcgctg ctggcccggc
     7261 tggcggcgga ggcggtcgac ggcctgggcg ggtacggcgg tgcaccgggc tcggacggct
     7321 tctcggcgta ccagaccctg gagcggctgc gcccgcagac cctgctggcc cgggtgcggg
     7381 ccgaggtacg gggccggggc ggtgacggcg ggggtttcgc ggaccggctg ctggacgacg
     7441 agatccggcg ccgcatcgag gagttccggc ggatggtcgg ggcggaggcc cggcgccggg
     7501 tcgcggagcg gcgcgggcgg gacgagatcg cgcggcgggc cgtccggccc accgccgacc
     7561 gggtcgactt cctgtacgcg aaccgcgagc agctcgccga actgcgccgg gccgttcagc
     7621 cgctggcgcg caagctggcc acccggctcg ccgcccgccg ccgccgggcc gcgcgcggca
     7681 cgatcgacct gcgccgcacc ctgcgctcct cgctgtccac gggcggcgta ccgatgcggc
     7741 cggtgctgcg ccggcgccgc ccggtccgcc ccgaactggt gctgctctgc gacgtgtccg
     7801 gctcggtgtc cggcttctcc gacttcacca tgctcctcgt gcaggccctg cacgaccagt
     7861 tcggcaaggt ccgcgtgttc gccttcgtca accggctgga cgaggtcacc ggcctgctcg
     7921 accacggccg cgccgacccc gacggcctcg gcgcccggat ccgcgccgag gccacgctca
     7981 ccggctggca cggcagcagc gactacggca tggcgctggg cgagttcgcc gagcggtacg
     8041 gcgccgccgt gggcccgcgg acgacggtgt tcgtgctcgg cgacgcccgg accaacctga
     8101 gcgacccgaa cctgcccgcc gtacgcgaac tggcccggcg ggcgcggcgc gtgtactggc
     8161 tgaaccccga gccgcgcgac cggtggggca ccggcgactc ggccgcgccc gcgtacgccg
     8221 agctggtcga gatgcacgag tgccgcacgg cccggcagct cagcgggctg atcgccggcc
     8281 tgctgccggt gtgacgccgg gcgccggtcc gtgatccact ggcccccacg ccgaccccga
     8341 cagcgaggac gtcgccatga tccacccgcc cgtgccgctg ggcaccttcc ccaccccgct
     8401 ggaaccggcg ccccggctgg ccgccgcgct cgggctcgga ccggacgacc tctgggtgaa
     8461 acgggacgac ctgaccggcc tgggcggtgg cgggaacaag atccggaagc tggagtgggc
     8521 ggtgggcgcg gccctcgccg agggcgcgga caccctggtg accaccggtg ccccgcagag
     8581 caaccacgcc cggctgaccg ccgccgcggg cgcccggctc ggccttcggg tcgtcctcgt
     8641 gctgcgcggc gccccgggcg cctcacgctc cgggaacctg gcgctggacg gcctgttcgg
     8701 ggcccggctc gcctgggccg gggcggtgga ccgggccggg ctcgacgcgg cggcggccga
     8761 ggtctgcgcg cgcctgcggg ccggcggtgc ccgtccggcg ctgatcccgt tcggcggttc
     8821 gagcgtcctg ggcgcacgcg gctacctgcg ctgcggtgcg gaactgcgtg agcagttgcc
     8881 ggacctgcgg acggcggtgg tggcgctcgg ctcgggcggc acgatggccg ggctggtcgc
     8941 ggccctgggc agcgcgtcgg tgctgggcgt cgacgtgggc gcgctggccg acccggccgc
     9001 cgcggtcgcc gagttcgcca ccccgctcac cacggaggag gtcgcaccgg aggagctgcg
     9061 gatccgccgg gaccaggtgg gcgccgggta cgcggccctg accggcccgg tccgcgaggc
     9121 tctccggctg gccgcgcgca ccgagggcct ggccctggat ccgacctaca cgggccgcgc
     9181 cctggccggc ctgcacgccg cggtccggga cggcggtatc cgccccggcg agaagacggt
     9241 cttcctgcac accggcggcc tgcccggcct cttcggccat ccggacgcgc tcgcgttcgc
     9301 ggaggagggg gcgacggtcc tcgacgggtg agggcctgtg cccatacagg ggtggggcgc
     9361 acgacgcggt gggcggcggg ccggtgccgc gcttcccgcc ggaccgcggt ccgtcgacgt
     9421 gtctccccgc cggccgcgtc gatgcggccg gcggggagac aggcggacgg gccctgctcg
     9481 ctcactggcc cttcgcgtac tccttcgcca tcgccccggc gaagtcgtgg accacgacct
     9541 gctcgtcacc gaccacccag gcgtcgtggc ccggcgggca gacgaagacg tcgcccgggc
     9601 cgacctcgcc ctcgccgccg tcgtccatgc ggatgtgcag ccgtccctgg accacgtacc
     9661 cgttgtggtg gacctggcag ctctcggtgc ccgcgatcgg cgccacggac tccgaccagc
     9721 gccaccccgg ttcgaacgtg cccaccgcga agtcgagccc ggtcaggtgg agggcttcga
     9781 ggtggccgcg gggaaagtca cgccgttcgt ccggcttctc gaccgtcttc acttccagca
     9841 tgacggtgtc ctcccttccg gccgctggcc gcggccgggg ccggcccacc gtccccggcg
     9901 gcctcggacg gcaccggtgc tgcgacggcg gccgtacccc acgccaccat cgtcggcctc
     9961 gcggcggcac cgcgccatcc acggggaggg gacaacgatg tcagcgaggg accgcccggc
    10021 gtacggccct cagggcggcc agatagacga ggtcgagcag gaagcagccg acgtagaagt
    10081 agcgcatgag ggcgctgtcg tggcggggtg ccgggtcggc ggtggtgagc atcgcgaggg
    10141 aggcgcaggc cgtgcccagc agcttggcca gcgcgatgcc cgtggactgg ccgcgcgggc
    10201 cgcgccgggc ggccagcatc gccaggaaca tggcggacat cgccagattg ctgccgaacg
    10261 cggtgatcgt gccgccgccc tcatcgaact gctcggaggc gacctgcata ccggggtagg
    10321 cgagaaggag cagcgcggcg agcgcgggca ggtacaaccg gcggggcagg taagggaatt
    10381 cggaccggcc gtaacgtacg accgtgtagc cgatcgccag gtcgaagcag aaccagacga
    10441 tgtcgaccac gtgcatgacc ccggacgggg gccgcacgaa cgcgaacatg aactcccagc
    10501 tgatgttggt ggcgaaggcg acgaccggca tcccgtaggt gtgctcccgc agtcccgtgc
    10561 ggacgagcag tacataggcc gccgtccaga acacgcccgt gccgagcagg aacaccgtgt
    10621 gcaccgcctg catccccact cccgtcaacc ggccgtcggg tacgcgtccc tgattactct
    10681 ggcacggtga cagccagcga cacgccgtcg atcgcgatgg acgacaccgg agatccgccc
    10741 ctgcgccccc tgcccgagcg ggccgcttcg ctgctggcgc gggtcgacgc gccgccccgg
    10801 ctggtggccc acctcagggc ggtgcacgac gtcgccgccc agctcgtggc gtgggtgcaa
    10861 cggcactgtc cgcgactgga gtcggacgcg gaggcggtgc tgttcggtgc cgccacgcac
    10921 gacatcggca aggccctgca cccggccgag ctgtccgggc ccggcgcacg acacgaggcg
    10981 gcggggcggg agttgctgct gacgcacggg gtggaggccc gactcgcccg gttcgccggc
    11041 acccacgcct cctggacggc tcccggcatc ggcgtggagg acctgctggt gagcctggcc
    11101 gacaaggtct ggaagaacaa gcgcgtcccg gagctggagg acctggtggt ggcgcggctg
    11161 gccggggccg acggccggcc ggcctggcag tggttcatgg aactggacga gaccctcacg
    11221 gccatcgggg agggcgcgga ccgtaggctg gcgtaccaga tgtcccaccc gctcacccgg
    11281 ccccagtgac catccgctcc cccgcaccat gtgatccgcc tgctcacccg ccccctgtgg
    11341 gccacccgcc gagtgacccg ctccgacccc cgaaggtgac catgttcgcg acctctctcg
    11401 gtgccgacgg cgccgagctg tgcccgctcc agccctggca ggccgaggag ttcctcgccc
    11461 atgtcgaccg gggccgggag ttcatcgggc ggttcaacgg actcccggac gtggtcgcgg
    11521 acctggcgtc cagccgggcg ttcctggagg cgtacgccgc caaggaggcg gccgacgcgg
    11581 gcctgatccg ggcgatccgc ctcgacggca ccctggtggg ggcggtgatc ctgcgccgga
    11641 tggatgtgcc gcagggtacg gcggaggcgg gctgctggct ggagccggcc gcggtgggcc
    11701 gggggctggt gacgcgggcg gcgcgcctgc tcatcgactg ggcgatccgg gagcggggca
    11761 tccaccgcgt cgagtggtgg gtgtcggccg gcaacgcgcc gagcatcgcg gtcgcccgcc
    11821 ggctcggcat gcgcaaggag gccgtgctgc gggagagtca cctgtaccgg ggcgagcggc
    11881 acgacgagga gatctgggcg gtgctggcgc cggagtggcc ggccgtcccc ggagccaccg
    11941 cggcctgacc ccggccgccc gccgcgctac cagtcgcgtg ccgcccgcag cagcagggcg
    12001 cgcacccggg ccacgtcggg gttgtcggag gcgccgggcc gctggacgag gaagccggtg
    12061 ttgatcggcg ggtcctccgg ttccagcagc gcgacgagcg cgccggagtc cagcaggtcc
    12121 tggcagagat agcggggcag cacgctgaac ccggcgcccg cgaccacggc ggcgaggact
    12181 ccgcgcaggt cgggcacggt caccgcggcg gtccgggaca ggcgccggcc gaagacgtgc
    12241 cgccagtagc ggcgggcgat cggcaggtcc tcggcgtagg tgacgagcgg gacgccgtgc
    12301 agcacggcgg ggtccaagcc gccctgcgcc gcggccggtc gggcctcgga cccctgcgcg
    12361 ccccggcgcc ccgtcagccg ttccgcccag accggggccg cgaccagcac gaactcctcg
    12421 tcggtgagcg cgacggcctg gagggtacgg ccgcgcgggc gggtggtggc gatcaccagg
    12481 tcgtggcggc cggcgcgcag ttcctccagc agcggatcgg tcagcccggt cgccacccgc
    12541 agccgtacgc cctcggcgac cagcggcgcg agggccggca gggccttggt gcacaggagt
    12601 tccgccggtc cggccagatg gacgggttcg gccccggtac cggccggcgg ggtggggccg
    12661 gcgacggccg ccagctcgtc caggggcgcg gcgatccggg ccgccagctc gtcggccacc
    12721 ggggtcggcg cgactccgcg cggcagccgc tcgaacagct cccggcccgt ctgccgttcc
    12781 agcgcgcgca tctgcgtcgt caccgtcggc tgcgacagtc cgagcaggcg tgcggcgccg
    12841 gtgaaggaac cggagcggta cacggcgagg aaggtgcgca gcaggttcag atcgagggaa
    12901 gcggtctcca ccgtgcgagt atcaccgccc ggggctcgcc ggagccatag gcgatccgat
    12961 gccgtggacg gcggtcggcc ccggatgtct atgggtagcg cccggctgcc ggtgccggcg
    13021 gcgcggagaa ttcgtcggcc gccgcctgca acctggcccg gggtcggacg tctgtcgggg
    13081 tggaggcctc cgtttcgacc agatgtccga ccccgagcga ccgaaggaac ccatgtccgc
    13141 acatcccgcc ccgcgcccgc accgcacccg ccgactgcgc accgccctgg gggtttccgc
    13201 cgtaggcgcg gccctggccg tcaccggcac cctgaccgcc caggccgacc cggccggcac
    13261 ccgcaccccg gccggcagcc acccgacggc ccgcaccgag cccgcccccg ccccggcgga
    13321 cgcccacgcg accccggccc gcaccgccca cccgtccccc gtgccctccc ccgcgcgcac
    13381 ggcgcccccc gccaccggcg cccgccacgg ccaccccttc ccccgtgccg gccgccccga
    13441 gcccggtgcc ggccaccgcc gctcccgcgc ccgagcaccc gacccccgca ccggagcacc
    13501 cgaccgccac gccggaaccg gcccgtccgg cgcccgttcc gcacccccgt cacccccgcc
    13561 accagcgccc cggcaccccg gcgccggttc cgcagcagca ctgaggcagg gccggtgcgg
    13621 gggagccgtc acgcggcggc tccccgcacc cggcccggga gagtccatga cgacagcgac
    13681 acccctggcg accgccctgc cctgggaacg ggccggcacc cggaagcccc ccgcgtcctg
    13741 gcggcgccgg gcagccgcgc tgcggcaccg cgtgctcgcc cgcacccgca ccggtacgac
    13801 accggccgcg cccgggaccg agcccggcac cggcacccgg cccgccgtcg acaccggtcc
    13861 cccgcagggc atcgaggagt tgtaccacca ccgccggctg tccctcgtac ggctggcggt
    13921 gctcctcgtg gacgacctgc ccacggccga ggacgtcgta caggacgcgt tcaccgcgct
    13981 gttccggcgg cacggccacc ggctcgcggc gctggacgat ccggaggcgt acctgcggac
    14041 cagtgtcgtc aacgccgccc gctcggtgct gcgccggcgc aggaccgtac gggcgcacac
    14101 ccccgccccg gaggggcacg cgcccgcccc ggaggaggac gtcctgctgc acgaggacca
    14161 ccgggaggtg ctggcggcgc tgcgcacgct gacccggcgg cagcgggagg tgctggtgct
    14221 gcgctactgg tcgcacctga ccgaggccga gatcgcggcg acgctggggc tgtcgcgcgg
    14281 ggccgtcaag tccacggcca gcagggcgtt ggacgccctg ggccggcgtc tggaggggct
    14341 gcgatgaacg agtccggtac gggcatcacg gcgacgccgg tcgaggaacg gctgcgggcc
    14401 gccctggccg cgcgggcgga ctccgtcggc ccggccgacc tgcgcccgct gcgcccgccg
    14461 gccggggcgg tgcggtcccg gcgggtgctg gtgcgccggg tggtggcggg ggtgctggtc
    14521 ctggccgccg cggccgtgct ggtgttcttc tcggtacgcg gcggaccgcc cgcgccccgc
    14581 ccggccgagc ccgcccgctc cccccacccg ccgaccggta cgccgtcccc ggtcccgagc
    14641 ccggtgagcc cgtcgacggc ccggccgtcc ccgagcgcac cgcaacggtg atccgacccg
    14701 cgccctcccc ctccgcgcga cggctgctgc cccgcctgac ttccgcgaac acggcggtgt
    14761 cgtcaacgag gccggtcagc gagcggggtg cttcggcggt ggcgcggaag cgtcggaggt
    14821 tccggtccgc cgacagcggg ttgacagggt tcggcgtcgg cggggcgtgc gatcccttcc
    14881 gggtcgacgg ccatgactta cgccggtcgc gttccctcca gcgcgcgccg gaaggccaca
    14941 ccgcgaccgt agccggcgtc gcggtcgact ccacgatcgt ccgggctcat cagcacgccg
    15001 tcggggcctg ccggaggggg tccccgtcgg cgagccggac ggccgtgccc cggacggtcc
    15061 cgcggcggcc tgaccatcaa gatccacctc gccgcggtca gccgctgccg accgctcgcc
    15121 ttcgtcgtca cgcccggccc ggcaggcgag gcgcaccact cccgcgcgac cgcgaccacc
    15181 tccgcaggcg tggcatcccc gccttcctcc ggtcacacac tgatccgaac gagaacgcct
    15241 aggcggccag tgtctcgtcc tcctgggggg cgtgcgtacg gccggtgtgc tcctcgagga
    15301 gtgtgtctgc cgtgagcaga gcctgctcga tggtgcgggc cccggtcatc acgcacagtg
    15361 tgtccacggc gtcttcgaga ttcatgctgg tggagcccgt ggggtgcaca tcgtgtgcga
    15421 tgcgcgcctg agcgaaccgg gccagcacct cgcgcagttc cttctccgtg ggaaggggca
    15481 tgctgatacc tcctgtgggg tgtgtcgggg gctctctaac aagcagcggc ctctgccacc
    15541 gtcgcccgca ccttcaggag cgtgtcggcc cccgtgattt ccaggagtcg gcgcacctgc
    15601 tgcgtcggtg ctgccacgcg gaggtcggcc ttgtggtggg tgaggatcag cagattcagc
    15661 agcgtcgagt ccccgaaggt gatgccggag gcgtccagga ccaccttgcg atgcgcctcg
    15721 gccgcggtgt ccagagcctc cgcgaggggc gtgatcgagt acatgtcgta ggagccgcgc
    15781 gcactgacga cccaggcgtc gccgtactcg aactgcacca ccgcggcctg gtcgtgtatg
    15841 cgcagcggcg ccccgcgcac ttcgtccggg cggtccgtga ccccttcttc caagaacacc
    15901 tcgggtcctc ccgtgtctcc cctgcttgga tcacgctagc gattacgcga aaactatgtc
    15961 atgcattcgg tgtccggcaa accaggtcag tagaatgccg tgcatggttg cagtgcctgg
    16021 atctcacacc ggatggacgt tcatcaccaa ccatgcgcgc gtactggcgg ccatcgccga
    16081 caacccgaac atccggatcc gcgacatcgc tgcccactgc cggctcaccg agcgtgccgt
    16141 ccagcggatc atctccgacc tcgagcagga cggttacctc tcccacaccc gcgaaggacg
    16201 cgccaacacc tatcgcatcg atccggacaa ggtcctgcgc cacccggcgg aagcaggcct
    16261 gaccgtggcc gcactgctct ccctgctcgt ccgggacgag accgaccgca tggggaaacc
    16321 cggcagccag tccccccgcc tggctggtgc cggcggcgcg agctgaggct gccgctcgga
    16381 tcctcacggc gtcgggctga ttcggacgac aggtcccggg ccaggtcgtc cggtcccgcc
    16441 cggctcggtc cgtcggctgc ggcgcgcgga ccgcagtggg gcgggccggc cgcagtgacc
    16501 ggattgaccg gcagcgacac attccgcgca aggccgtcac cgccggtcgg acgccggcaa
    16561 cggccctggc ggcgatcgac ggcagccgcc tgggcgtgcc gcgacacgac gggcagcggt
    16621 ttgcggagga atgtgtggtt cttcagcgac cccgcctggg ctccagccct gaacggcccc
    16681 ctcgtccggc gcaccgacgg caaccgcgac ggcggggccc tctgcgtcaa gggatctgcg
    16741 ccagggaacc ccaccgtcgg ccggtgttgg ggcagctggg tgccggggca gacggacagg
    16801 aacctggaac agctgaagga gagaccatgg cggacgattc atccatgagg gctgtcggct
    16861 gggcgcgctc gttgccgatc agcgccggag tgcgggaagc caggaactgg acgcgttccc
    16921 acatgaccgc actcggctgg gatcggactg cacccgctct ggtggacgcg gtcgtgctgg
    16981 ccgtctcgga gttggtcacc aacgcccacg tccacgccca cagcgccgca cagctcatcc
    17041 tcacctggga cgaggaatgc ctgcacgtga cggtgcatga cgcctcgccc cggctgcccg
    17101 agcaacgccg cacggatcac gacgcccttg gcgggcgagg gctgctcctg gtcgacgccc
    17161 tcgccgacga ctggcagatc cgccgttgcc cccgcggcaa ggacgtcacc gcctgcttcc
    17221 aaccgcccgc ttcggaggag ggacgagcgc gagaagcaga atgagcagca acggagacgc
    17281 aattatcggc cttgtgcgct gccgcccgtc ccgcaccgcg ccccgaccgg cctgacggcc
    17341 cgccgcctca ccggcgagaa cgcgatccgc cggcgcgacc cggcacctcg cgtgcttcgg
    17401 tgagggcccg ctgcctgagg ttgccgccga acaactggat cgtggtggcg gccaggacgt
    17461 cgtcgctgcc gatggtccgc ccgtccccct tgcggcggga cagggcccgg tgggaatccc
    17521 cggggaacgg gggtggggcc ggttcgcccg gcatcaccag ggtgaccgta ccgaaacgcg
    17581 tgaccccgcc ctcgcgaacg accatggccg cgtcccgggc gaggtccgtc aggaacgcgc
    17641 tggctattcc gtccaggtcg cggaccatcg ccgggacggc cgtcactccc tggctccgca
    17701 gcagcttcct gaccccggcc tcgaacctgt gggcgccgac cacagcactc ggcttgcgcg
    17761 acccgctgcg cttgcgagaa ggcacgagga cgcccgcggc gtcgtacagg acaccggtca
    17821 ggcctcgaaa cgtcgggctg tggtcgtacc acttggtccc cacctcgagt tcggcgttcc
    17881 ggtcgatcgc cgacagaagg tcaccgggaa tcagcttctt ccgggcctcc tccgccgccg
    17941 ctctcctcgc gccgtcgatg atctccgtca gcacggtccg cgtcaccgac gcggcggccc
    18001 acgcggccga ccgggagacg tgcagcgagg tcacgtccct gaacaccgct ttgacgagag
    18061 aaggcttgaa cggcgggaca tccatgaccg aggcggtccg ggggccgctg cgtccagggc
    18121 gtgcgggctg tgcggtcatc ggaaggaacg ctccctgctg tcggagtggt cagaggcccc
    18181 cacttcacca cgcagacccg ctctcctccc ccatcctccg tccgcggggc cagggcgggg
    18241 cgcggggatc aggccgcggc cgtggtgccg cacttccgca gcgcctgcca ggtgccgggg
    18301 ccgactgtgc cgtcgggcgc gaggccgtgg tcgcgctgga accgcttgac gaccgcttcc
    18361 aggcccgccc cgaacaggcc gtcgacgggt acgtcatagc cgcagcgccg cagcaggcac
    18421 tggacttccc ggacctcgtt tccgctgtct ccccgggata ccggggcggt gccggagtag
    18481 tagccgcacc agagcgcccg gccgtcgctc ggcgcggcag ccggtgccgg cagggacggc
    18541 ggggccgggg gcgcggtgga ggctcgggcg ggcgcggccg tgagcgtgaa cgcggccagg
    18601 gccgcgacgg tgaacgtgcc gatccatgtg ccggcccgcg tgcggccacg gtcgcgggac
    18661 gtgcgtgagg tgagcaaggc ggtctccttt cgcatgtcag gtgacggggg cggcccaggc
    18721 cgcctgccag gtcgccggtc cgacgatgcc gtcggcggtg agccgcttct ccttctggaa
    18781 cgcgaggcac acctgccgcg accggctgcc gtacaccccg tcggcgtcga gggaccagcc
    18841 cctctcccgc atgcgggcct gccaggtggc gaccccgggg tgccgggtga acggcgggta
    18901 ggtgaacagc acgcccggcc agggcggcgc gtcccggtgg gagctgtcgc cgtccgcggg
    18961 ggcggtcacg ggggcgcgcc aggacgcctg ccaggtgtcg cggccgacga cgccgtcgac
    19021 cgtgaggctc ttctcccgct ggaaggcgag gcacacccgg cgcgactgct ccccgtacgc
    19081 gccgtccacg tcgatcgtcc agccgcgtct gcgcatctgt tcctgccacg tcctcgcgct
    19141 ccagtgcacg gtgacgggcg ggtattgcag cagaacaccc ggccagggga cctcctgccc
    19201 gggcggaggc ggctcctcac cgccggggcc cggggcggtt ccgggctcga accgcccgtc
    19261 ccgtacatag gcgtagagcg cccccgggca ttccgtggcc gtcagatcgc ggtgcccgac
    19321 gatgcgggcc ccggcgcctc ccaaggagcg caggccggcg atggcggtgc ggatcgcctc
    19381 gaccagaccg gtggtgaccg ggtcgtagcg gccgggcgtc ccgcccgtca gcgcgcagac
    19441 cgcgtagaag cggtcgttgg cgtccttggt gccgttcgca ccggtcctga cgccgtatcc
    19501 gcgcccttcg aacacatagc cgtgcgggca tgcgaggaag gagtaggcga tgtcgtcgta
    19561 ctccccgttc atatgggtgt tctgcacact ccgcaccagg gatgcgcact gagcatggcc
    19621 ggcgagggcc agaggcgtct cacctatgtg gtggacggcc acaccgccgt cgccgggccg
    19681 tatgtcgtgc gacaccttct tcggcgccct ggcgccccat gccgcacggg tgacgagctg
    19741 aggcgccatc agcgctcgcc cccgcccgtg cactggaccc agccgttgag cggttcgcgt
    19801 gacacgccct cggcgtacca gtggtcggag atgaccggaa tgatggcgtc cgggtcggtg
    19861 gggctgagca tgtcccgcgt gccgagcccg gccggggaag ccgcggcggc ggcagcggac
    19921 cctgcgccgc tcagggagag cgccgtcgcg gccgctgccg agaaggcggt caggaggacg
    19981 tgtctgcggg tgaggtgcat gcgtctcctc atgtcgaaac gggcttgtcg gaagccggga
    20041 aaccggccgg ggcactgccc cggccgggca acgctcgcgc gtcagccgcg cagcgccctc
    20101 caggtgttcg ggcccgcctt gccgtcggcg gcgagcgggt ggtccgcctg gaacgccttg
    20161 accgcgcgct cggtggccgc cccgaagatg ccgtcgatgc cggacgagcc gatgctgtaa
    20221 ccccagacgt cacgcaggag gcactggatc tccttgacgt gggcgcctcg gtcgccgcgg
    20281 tccgcgtacc gggtgccgct gtggtagccg caggagacgg cggccgcggc gacctgcttg
    20341 tccgaggccg gggccggagc cgccggggcg gccatggcgg aagcggctcc gccgaggagg
    20401 agcgcgccgg cgagggcggc ggggacgaga ccgcgcaggg tcttggtcat gtgtgcgtat
    20461 ccctttccgg tcaacggtgt tcgggcaccg gaggcacgcg tcggtgctcc ggataccgca
    20521 cgtcgtcgga cgacggacgg acaggcgctg ccgtcccgtc ctccggcccg accgatcttg
    20581 gcgggcgagg ttttgttcag caccccctca ccagggactt ttcaattccg gaa
//
