LOCUS       NZ_AP024135            21494 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 729952
            Orig. end                         :: 751446
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21494
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21494
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21494
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11494](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11494)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    163..177
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    1567..1581
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    1996..2010
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     gene            2332..3324
                     /locus_tag="K6K39_RS03080"
                     /old_locus_tag="EASAB2608_00657"
     CDS             2332..3324
                     /EC_number="1.14.19.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) delta9_cd03505"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433566.1"
                     /locus_tag="K6K39_RS03080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00657"
                     /product="acyl-CoA desaturase"
                     /protein_id="WP_223283689.1"
                     /sec_met_domain="delta9_cd03505 (E-value: 9.7e-96,
                     bitscore: 321.0, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSPDRPEGLRAPLPDTVPVGLPLRTGYLLTLVVGPLAVLALVL
                     PVALAGGWGPRWYDGVLGAGMYALSIMGITAGYHRHFTHLSFKAKRPLRIALGVAGGLA
                     MEGPVTLWVAEHRRHHQYADREGDPHSPWKYGTGRRALLKGLWHAQVGWFTSTLRSHHP
                     RYAPDLLADPDVRRLDRWYPLTIAVSLGLPPALVLAVTQDARSALVTFFWASLVRYAVV
                     HHVTWSVNSVAHAFGPRHYATRDQSRDVPWVALLTFGEGWHNLHHADPNSARHGGLRGQ
                     PDLTAWLIARFERWGWAYDVRWPDERRIAARLRAEAAGRRVPYGQVPAK"
     gene            complement(3306..4055)
                     /locus_tag="K6K39_RS03085"
                     /old_locus_tag="EASAB2608_00658"
     CDS             complement(3306..4055)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535709.1"
                     /locus_tag="K6K39_RS03085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00658"
                     /product="DUF4239 domain-containing protein"
                     /protein_id="WP_059246909.1"
                     /transl_table=11
                     /translation="MIETFAVVLGIAMVTAGIVVIRHHYWPPAPDEEPREDVAEYISMM
                     VGVLYALVLGLSMVSVWETRSGAVGHVQAEASAAHQIRLLSAGLPPLEGERTRSAVDAY
                     VHHVVSTEWPAMAAGQPPGRRGWDLLNDLRAAGQIPAGATAAQQATLQETLAQLSTLDD
                     ARRGREADAADTLSPVLWFGLIVGGLLTVVFMFMFGVRRSFTHVVMVMGLSALITFTVL
                     LVYQLNEPFNGIFAVDSSPFTRYFAGT"
     gene            complement(4134..6284)
                     /locus_tag="K6K39_RS03090"
                     /old_locus_tag="EASAB2608_00659"
     CDS             complement(4134..6284)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS03090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_00659"
                     /product="hypothetical protein"
                     /protein_id="WP_221333957.1"
                     /transl_table=11
                     /translation="MLPLLMAVCGAPAQRAVADGAGNHGLALQVAVNTRPGTGATDPGI
                     RVGHPLVKTYHLINRTGADLYDVRVNDPGLPHADIRCPGGGDHLPMLRGLDSATCTAWA
                     TARPGTWIADVTAVGSVPSLGTESRAVARSGYAGVGGALSLTETVTTGAGSLGRALTLG
                     RATVLYDVTNTGNRTVYDLRLSDPALQPPAIVCGSGGDVVPSLEPGGSARCVATVERPP
                     GHYLSKGRVKGSDRIKTLGPDGCPKPPPMLKDWAIGHFTVDEPTPPPVPPPLPEPPAPE
                     PPTLTPAPVPPPPPPPVLPPPPAPAPVPPPVPVPPPAPPVLPVPPGVVFPPPPPLPPAG
                     TGAPVPGVAVPAPGVAAPAPGAAAPAPGVAAPGAAAGAAAGAGAVAGAGAAAGAGAVAG
                     AGAAAGAGAGAGAAAAGAGAGAGAAAGVAAGAGAAAGAGAVAGAGAAAGAGAAGAGAAA
                     GVGAAAGAGAAAGGAAAGAGAAAGAGAAAGGAAAGAGAAAGAGAAAGAAAAGAGAAAGG
                     AAAGAGAAAGAGAAAGAGAAAGAGAAAAGGAAAAAGGAGVAAGAAAGATAGQGGATGGA
                     ATGGAATGGQATQGQSTGGRATEGQTTGGQATEGQTTGGQATEGQATEGQTTGGQATEG
                     QATEGRSTGGQTSLPSRPPATAPGTASPRPRPQRPPDTSIMSRFIRPGGGPTGLGLLAV
                     LFLMLIPAALAAALLGSRRIGK"
     misc_feature    complement(5781..5783)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6482..6940)
                     /locus_tag="K6K39_RS03095"
                     /old_locus_tag="EASAB2608_00660"
     CDS             complement(6482..6940)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676764.1"
                     /locus_tag="K6K39_RS03095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00660"
                     /product="flavodoxin family protein"
                     /protein_id="WP_059246907.1"
                     /transl_table=11
                     /translation="MPTLLIVHHTPSPHCQALFEAVVSGATAPEIEGVRVVRRAALSAT
                     ASDVLAADGYLLGTPANLGYMSGALKHFFDQIYYPCLDETRGRPFGFYVHGGNDVTGAV
                     RAVETVTTGLGWRRAAAPVTVTGDPGKAGAQACWELGATLAAGLMPGA"
     gene            7055..7696
                     /locus_tag="K6K39_RS03100"
                     /old_locus_tag="EASAB2608_00661"
     CDS             7055..7696
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327851.1"
                     /locus_tag="K6K39_RS03100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00661"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_059246906.1"
                     /sec_met_domain="PCMT (E-value: 1.8e-05, bitscore: 23.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEEDGRPPAAVVFDALGPAYERAFAGSAPHRASLDRLLELLAPG
                     SRVLDVGSGTGRPTAQTLAGAGHRVLGLDVSPVMVDLAARQVPAAEFRLADIRETPLAD
                     ASFDAVCAYFSLLQMTRAEQAAVVAKLARAVRPGGLVALATVPLDVEDVEAVFMGQPVR
                     VTSFAAEAFTGLVSGAGLTVLSEEHEVFTPAHPEAVPEPHLFVLARRGAD"
     gene            7782..8504
                     /locus_tag="K6K39_RS03105"
                     /old_locus_tag="EASAB2608_00662"
     CDS             7782..8504
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386747.1"
                     /locus_tag="K6K39_RS03105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00662"
                     /product="lipoprotein"
                     /protein_id="WP_059246905.1"
                     /transl_table=11
                     /translation="MQVRVGTVGGRMVVAAALAAMLGGCAGSADGDGKKSAGASASAEG
                     SAAGGAGAKGGAAPAGARIGGAGSACELPVSFHVAKRWRAKSVDAEKELAKASKSEDGD
                     LSGALAEAFLRQGPVTAACEIDAKPAGNIGFLRVWTGKPGEPGTASADSVLRAFVAAED
                     NVSKEKYRSVRTGGGLDAVEVEYLYTSKLLEETKKERALAVSTPQGSVVLHLGGMDTQE
                     HEEMLPAYELAKQTLMLS"
     gene            complement(8491..9150)
                     /locus_tag="K6K39_RS03110"
                     /old_locus_tag="EASAB2608_00663"
     CDS             complement(8491..9150)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044287.1"
                     /locus_tag="K6K39_RS03110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00663"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_094372415.1"
                     /transl_table=11
                     /translation="MPTHDRTAVIRPYHPADREAVADVCVRTAHNGGDSRAIYPDQRLM
                     PSLFAEPYCHFEPELAFVLDDGTGRAVGYIVGTADTGRFVENFRRTWIPRLAGRYPEPA
                     LPPRTPTEEMIRLLHHPERMLVPELAAYPAHLHIDLLPPWQGRGYGRRLMRTFLDALHG
                     QGVQAVHLGMVTVNTAARAFYDRVGFHEIPVVDAGPLTYLGRATTADRRGDGLRRA"
     misc_feature    complement(9169..9183)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     misc_feature    9170..9184
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    complement(9344..9358)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.61"
                     /tool="antismash"
     misc_feature    complement(9416..9430)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            9502..9972
                     /locus_tag="K6K39_RS03115"
                     /old_locus_tag="EASAB2608_00664"
     CDS             9502..9972
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS03115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_00664"
                     /product="hypothetical protein"
                     /protein_id="WP_221333959.1"
                     /transl_table=11
                     /translation="MSTPTQDSSFRITSAPNITYAQWDTERFETTSTAWTALPGASIDL
                     RLGQGAPSYGAIFVATFSAEVLSSDQGGDGQGLLAATVFFGDEQAEPLSNNHRYVTARG
                     NPEWSSHTFIRVARFEPEFAVRQVNAQVKLRVSNADSGGVQNWVLKIERYNL"
     gene            complement(10001..11494)
                     /locus_tag="K6K39_RS03120"
                     /old_locus_tag="EASAB2608_00665"
     CDS             complement(10001..11494)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033444.1"
                     /locus_tag="K6K39_RS03120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00665"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_221333960.1"
                     /sec_met_domain="T2TS (E-value: 1.8e-73, bitscore: 246.7,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPHLPARRARLARRVLERIGPNGLIPAPGSSRVLESALLLALLT
                     KEDLAPAAADLTRRYLKHTLDTDPPDALQCAFAHVALGDALTGSTTVRDALASFDHFST
                     PRKLLTFQTLLTEITDGAHRRDLPADAFDAHGQQAWLQLQMLALKTITAPRAATSDDWS
                     RLALALRPGPPWQANHLARLVALLALRKHPTHQPAVREALLRISADQQPGGGLPFVTGM
                     DVFASAVAGIALTRTRPLDPRLAATADALAARQNPDGGFGFTVGVTQSDVDDTSYTLEF
                     LRAAAPVRHARTITAAEEYLLAQRNPDGGFPTFVHGAPSEIAMTAGAVNALAPNPARRP
                     DVERAVAFLLEADHLVERSWSRNATNALFRVTLALATLTPSAPAPLRAAARAARQRAIR
                     YLTETQEPDGGWGHEPGDTSDPISTAYATVALAAAPASAAPALHRALGCLLAAQQPDGG
                     YASRTDQAGPRPLLYDVPALADIWVLLALSACRPRSGRE"
     gene            complement(11522..12007)
                     /locus_tag="K6K39_RS03125"
                     /old_locus_tag="EASAB2608_00666"
     CDS             complement(11522..12007)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956086.1"
                     /locus_tag="K6K39_RS03125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00666"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_059246901.1"
                     /transl_table=11
                     /translation="MHSAEVIDFVDGSDRFVRRGRRGQAGAAGLYYRVAATVLLAGPGH
                     VLVYRRPSTAAVYPDHHDVLIGGSVRAGETYRQAARRELAEELGIRTDPVEALRLRRPS
                     PVGPCHLAVHTARLVAPPAPDPAEIAHHDLWPIAAFLAAPPRPVVPCGRHVLHRLFG"
     misc_feature    12043..12058
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    complement(12061..12078)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.25"
                     /tool="antismash"
     gene            12115..13401
                     /locus_tag="K6K39_RS03130"
                     /old_locus_tag="EASAB2608_00667"
     CDS             12115..13401
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474157.1"
                     /locus_tag="K6K39_RS03130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00667"
                     /product="cytochrome P450"
                     /protein_id="WP_059246900.1"
                     /sec_met_domain="p450 (E-value: 1.8e-28, bitscore: 98.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATAPPATAVPELPQAEVARWRAAGAPLIDLLTRAHRLGPVSGVP
                     LADRPMVLVTDPAAVHHVLALHPDRYVKRSHRMRHLLGDGIITVDGTPWRRQRRLLQPQ
                     FTVQGVHRYERLMRDAAAHTARAWADSARTGRPRDLAADMRRFSLDVIWRATTGQALDD
                     TTHRQFLAAGRIVAATAALGPSTGTTAPDLVDDHADVEAVTARAIAAARATRTPSLLDA
                     LLGAAELPDGDGRLVRDNFVTFLVAGYETTAATLSWLLLLLHDNPDRRAWALARGPAGS
                     PARTAAIRALIGETLRLYPTAWLLLRQAARDDVLAGHRVAAGTTVAVCPYLTHRDPRLW
                     ADPGLFRPQRFVDPPQRPALGTYYPFGLGPRACLGAQFGLREMAVLAETLLPAFDFALT
                     TAPPGPVFDLTVRPDGPLVATVTARNARG"
     gene            complement(13450..15402)
                     /locus_tag="K6K39_RS03135"
                     /old_locus_tag="EASAB2608_00668"
     CDS             complement(13450..15402)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676760.1"
                     /locus_tag="K6K39_RS03135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00668"
                     /product="DUF1996 domain-containing protein"
                     /protein_id="WP_260336094.1"
                     /transl_table=11
                     /translation="MLGGAGLVAVNVYASAGEGWGDGSGTETTGRVRSTGMATIDCPDI
                     GSRLTAVPDAARPDVDRELARLDQQTAAAYRQLQQAGQGGGADAASADDGIMNPLEEKR
                     SVSIGRITDAIDRAGERPQGLESLAACTLRPGETGQATGVPGDGDGRNGTGQEQSGTGQ
                     EQSGTGQGQSGAGQGGNGPVASDYADITAVPPEAPAPQPQAGASRGTFTTDCGVNANGL
                     FNSDNVIVAPGVSNGAHHVHDYVGNQANNAFASDEDLARAGTSCVDQGDKSSYYWPVLR
                     LQNGTQERDAGAPGGGTEGNAGQIVTPRQVTLTFVGNPLGEVTAMPRLLRIITGDAKAF
                     VNGPGNANASWSCTGHEDRQLKDKYPLCPPGSDVVRTFRFQSCWDGRNIDSANHRTHVA
                     FAAPDGSCPAGFRPIPQLVQRIVYDVDAPSLADGGRTVPLFAVDSFPEQLHKPVTDHGD
                     FINVFDEDLMREMVDCINSGRTCGPSGGDSGTTATPPASPGSGATPAPGDGAGRQPAET
                     GTSAPTPSAARTGEARRHDVTASPARTAKRDTDDGAAPAEPVEPRSTPVRSTSARPTPS
                     SPSPSPSAPASAAPGAPGRTTAAAYAPPPAAPSAPRAAGGSLAETGAQLWPAAVGTLLA
                     LSGLFMFLRARRLRY"
     misc_feature    15629..15643
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.66"
                     /tool="antismash"
     misc_feature    15640..15653
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.09"
                     /tool="antismash"
     gene            15763..17487
                     /locus_tag="K6K39_RS41670"
                     /old_locus_tag="EASAB2608_00669"
     CDS             15763..17487
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013073.5"
                     /locus_tag="K6K39_RS41670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00669"
                     /product="NlpC/P60 family protein"
                     /protein_id="WP_311737145.1"
                     /transl_table=11
                     /translation="MAPESRDEVRQRIASLYDQAENATGNFNATRAMAARSRSRGVPLA
                     KRPGRRPDPELAEVARQWFDAARAKLGPTVPAALPADRLLDGPAAPARSPERTGGLPGA
                     EREVRALPVGGGALGLTSGGQSLGLPGGGEALGLPGGGGSLGLTDGGEGLSLPGGGRDV
                     LALPGGERQNPGDGGPSARHPEALERGAAQAVAELTAASPADSAGRPPQSPETGRPALA
                     GADRLEPAGTALALTGGAAAEPAGWGAPGPASTAALPAAAPPTAQGTAAQPRPLPGSAA
                     SGRPSPAASKAGNRRKLDAARDLLSRHTGRLTLSGAAGLPAWAAGFEQVPHATTAETTP
                     PWQDPQWTASAPASAPAPARSTPATPAVATRPVGITAPATDTGSLPALTDTGPFSPLTG
                     TGPLSPLTDTGSLAPLTDTGSLPPLTGTGSFAAPTAATGSTPLPLPGPAAAPESPRALR
                     AAKAIAFARAQIGKPCVWGASGPDSYDCSGLTQVAWRAAGVTLPRTAHQQALAGTPVTL
                     AGIEPGDLVLFFDDDRHVGLHVGDGMMVHAPGPGSSVREESIYGAGEAAIHRIVRPA"
     gene            17775..19139
                     /locus_tag="K6K39_RS03145"
                     /old_locus_tag="EASAB2608_00670"
     CDS             17775..19139
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1285: ferredoxin fdxC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327819.1"
                     /locus_tag="K6K39_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00670"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_059246897.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.5e-07, bitscore:
                     29.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRPLRVAIVGAGPAGIYAADALLKSEVAADPGVSIDLFERMPAP
                     FGLIRYGVAPDHPRIKGIITALHQVLDKPQIRLFGNVDYPTDISLDDLRAFYDAVIFST
                     GAMADRELPIPGIDLDGSYGAADFVSWYDGHPDVPRTWPLEAEKVAVLGVGNVALDVAR
                     ILAKTADELLPTEIPPNVYDGLKANKAVEIHVFGRRGPAQAKFSPMELRELDHSPNIEV
                     IVDPEDIDYDEGSIETRRGNKQADMVAKTLENWAIRDVGNRPHKLFLHFFESPVEILGE
                     DGKVVGLRTERTALDGTGNVKGTGEFKDWDVTAVYRAVGYLSEKLPKLPWDIDSGTVPD
                     EGGRVIEEGGTHLQSTYVTGWIRRGPVGLIGHTKGDANETVANLLDDYAGGRLHTPATP
                     EPEAVDAFLAERNIRFTTWEGWYKLDAAERALGEPQGRDRVKIVEREDMLRESGA"
     misc_feature    19478..19492
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.0"
                     /tool="antismash"
ORIGIN
        1 ggggccgggc cgtgtcgatg ccgagccggc gcagctgccc ggcgaagggt tcggccgccg
       61 cggtgtccag tcgcagccgg acgccggcgc cggtgtgcag ccgcagcctg ccgtgggccc
      121 ggaccagggt gcggatcgtg ctctcgcccc ggcggccgta gaggatccag tcggcctcgg
      181 ggcagcgcac gccgcgcccg aggcggccgt cgacggtgag gccgaggtcc ggggagcgga
      241 cgccgatctc ccggcccatc agatcggcct cggcggtcac ccgcagcgcg ggctgtcccc
      301 agatctcctg ggcgacgacc cgggcctcct cgctggtgac gccgagggac agcacgtggc
      361 ggccggtgcg ccgcaggtcg acgcggcgca gcaggtccgc ggcgacgtcg tacgggcggg
      421 gccgccacag gtcgtccacc agcacggaca gggcgatctc ggtgtacggg ccgatcgtgg
      481 tgcagcggtg ctcgtacagc gacagcaccg ccatggcacg gcgggcgacc cggctcgggg
      541 tcatccaggt gacgtcgggc agcaggccgc gggcggtgtc cgcgtcgacg gggtagcaca
      601 ggtgggccgc ggaggagtcg tagtagcgca ccggtacgtc gatggggccg gccgtggtgg
      661 gcagcgaggt ggtgggcagg gtgaggaagg ggtagccctc gggcgggttg gcgcggtcct
      721 tgagctggta ggcctgggtg cgcacgacgg ggccgcggta gggggtgagg gcctcgtcga
      781 cgcgctcgcg ggcctcgggg atgacggtcc tgaggtgctc gatgtactcg cggagcatgt
      841 ggcacagcgg gaactcgtgg gtggggccgg tgtagtcgac ctcgtaccag ttggggtgcg
      901 ggtcgaacgc ggagcccgcg ccgcggccgt cgaggaccgg cacgatgtcg tgctggttgg
      961 tgatgctggc gacccaggtg cgcgggtcgg cgggtttctt ggtgtccacc ggggagccga
     1021 cggcgatgac gtgggtgacc cggtaggtgc ggcagaactc ctcgttctgg gcgaggttca
     1081 tcaccgcgat gccgccctcg ctgtgcccga tcagcgcgag gtcggcgccg cgcgggatgc
     1141 cgtagtccgc cagggcgagc aggatcgagc gggtgtacgg cgagtcggtc atgaacaggt
     1201 tgcgccaggc gccgacgaag tcctgcgggg agtcgttgcg ggggcggccg ggtgccatgc
     1261 ccggcgcctg gaggacgtac cgtacgacgc cgtccgggcc gcgcacgttc tgcagcagga
     1321 tccgcccgtc ggtggagagc atctcgatgt tccgcaggaa gccgaggaag gaccccttcg
     1381 gggcgatgac ctgcctttcc tggtcggtca ggtcgacggc ctccgcggcg ccctcgccct
     1441 tgtccatgcc ggcgaggtgg gcggcgctga tgccgtgcac cgggtcggcg gacagctcgc
     1501 ggccggtggc cagcgcccag ccggtctcgt cgttcttcgg gtcctcgtcc agcagggcgc
     1561 ggatcgcgag gagttcggcc atcagcggcg ccagcccgga cagggcgcgc tgcgcgccct
     1621 ggtcgcggaa gagggcgcgc agggaccgta cggccgccag gtccttgtcg gcggtgacgg
     1681 cctccgtcag ccggcgcatg ccgggatcgc gcacgaactc ggggtggtcg accagcacgg
     1741 cggcgatccg cagccgcagc gaggtgaccg ccaccagcgc ggccaggttc tcccggccca
     1801 gcacctcgcc ggcggcgccg aggacatggc ccatgcccct cggtgccgtg atggccgagc
     1861 cgccgaggcc ctgcttgttc gtcagggccc gcagcagcgc ccaccgggcg gcgaggccgg
     1921 cgcgggggcg gcggcgcgcg gcggcggcca gggccggggc gaacagtacg gtgctggtgc
     1981 gctcggacac cgcgcggatg ccctcggcga cgtcgaccac gtcccgcgcg caccggcgca
     2041 gctgttccct ggcgtcctgg ccgtccggcg cgggccgtcc gggtgcggtg ccgtccgctc
     2101 gcatccgacg ctccctgggt tcgacgacat ggggcgggcc gcgtccgagg tcgcggcctc
     2161 ggtcccatgg tcggccaggg ggaacgcgcc cgcaccttca tccatccagg tagaggttgc
     2221 cgccgggtgc cgtacggccg ccgagcctgg gcggcgcggg cagggggctg ccgcataatc
     2281 gccgcacatg accccctgtg ctcccccgcc cctcctcgtg ggaggcgcgc cgtgaccgtg
     2341 tcccccgacc gcccggaggg cctgcgcgcc ccgctgcccg acaccgttcc ggtcggtctg
     2401 ccgctgcgca ccggctatct gctcacgctc gtggtgggcc cgctggccgt gctggcgctg
     2461 gtgctgcccg tcgccctggc cggcggctgg gggccccgct ggtacgacgg ggtcctcggc
     2521 gccgggatgt acgcgctgtc catcatgggc atcaccgccg gctaccaccg ccacttcacc
     2581 catctgtcgt tcaaggcgaa acgaccgctg cggatcgccc tcggtgtcgc gggcggtctc
     2641 gccatggagg gcccggtgac cctgtgggtg gccgagcacc ggcgccatca ccagtacgcg
     2701 gaccgggagg gcgacccgca ctcgccgtgg aagtacggca ccggccggcg ggcgctgctc
     2761 aaggggctgt ggcacgccca ggtgggctgg ttcacctcga cgctccgctc ccaccacccg
     2821 cggtacgccc ccgatctgct cgccgatccg gacgtacgcc gcctggaccg ctggtatccg
     2881 ctgaccatcg ccgtctccct gggcctgccg ccggccctgg tcctggcggt cacgcaggac
     2941 gcccggtccg cgctggtcac cttcttctgg gcgagcctgg tccggtacgc cgtcgtccat
     3001 cacgtcacct ggtcggtcaa ctccgtggcg cacgccttcg gtccgcgcca ctacgccacc
     3061 cgcgaccagt cccgggacgt gccctgggtg gccctgctga ccttcggcga gggctggcac
     3121 aacctccacc acgccgaccc caacagcgcc cggcacggcg gcctgcgcgg ccagccggac
     3181 ctcacggcgt ggctgatcgc ccggttcgaa cggtggggct gggcgtacga cgtacggtgg
     3241 ccggacgagc ggcggatcgc cgcccggctg cgcgcggagg cggccggccg gcgggtgccg
     3301 tacggtcagg tgccggcgaa gtagcgggtg aacggggagg agtcgacggc gaagatgccg
     3361 ttgaagggct cgttcagctg gtagaccagc agcacggtga aggtgatgag cgcgctcagg
     3421 cccatcacca tcaccacgtg ggtgaagctc cgccgcaccc cgaacatgaa catgaagacc
     3481 acggtgagca ggccgccgac gatcagcccg aaccacagca cgggtgacag ggtgtcggcc
     3541 gcgtccgcct cccggccgcg ccgggcgtcg tccagcgtgc tgagctgggc cagggtctcc
     3601 tggagcgtgg cctgctgggc cgcggtggcg ccggcgggga tctggcccgc cgcgcggagg
     3661 tcgttcagca ggtcccagcc gcgccggccc ggcggctgcc ccgccgccat cgcgggccac
     3721 tcggtggaca cgacatggtg tacgtacgcg tcgacggcgc tgcgggtgcg ttccccctcc
     3781 agcggcggca gccccgcgga cagcagccgg atctggtggg cggcgctggc ctccgcctgc
     3841 acatggccca ccgcgccgga ccgggtctcc catacggaca ccatcgacag accgaggacg
     3901 agggcgtaga gcacgccgac catcatggag atgtactcgg cgacgtcctc gcggggttcc
     3961 tcgtccgggg cggggggcca gtagtgatgc cggatcacca cgatgcccgc ggtgaccatg
     4021 gcgatcccca gaacgacggc gaaggtctcg atcatcgact cggtctcctg tcgtctcggt
     4081 gtgctcggtg tgctcggtgc gtgcacggga cccgtccgcc actcgtccgc cgcctacttg
     4141 ccgatgcgcc gcgagccgag gagggcggcg gcgagggcgg ccgggatcag catcaggaac
     4201 agcacggcga gcagcccgag ccccgtcgga ccgccgccgg ggcggatgaa gcgggacatg
     4261 atggaggtgt ccggggggcg ctggggccgg ggacgggggg acgcggtgcc gggggctgtg
     4321 gccggggggc ggctcggcag gctggtctgg cctccggtgg accgaccttc ggtggcttgg
     4381 ccttcggttg cttgaccgcc ggtggtctgg ccctcggttg cctggccctc ggttgcttga
     4441 ccgccggtgg tctgaccctc ggtcgcttgg ccgccggtgg tctgaccctc ggtcgctcgg
     4501 cctcccgtgg actggccttg cgtggcctgg cctccggtcg ccgcgccgcc ggtcgccgcg
     4561 ccgcctgtgg ccccgccttg gccggcggta gcccctgcgg cggcaccggc tgcgacacct
     4621 gcgccgccgg cggctgccgc ggctcctcct gcggcagccg cacctgctcc ggccgccgca
     4681 cctgctccgg ccgccgctcc agcaccggcc gccgctccgg caccggccgc ggctcctccg
     4741 gccgcggcac cagcaccggc cgccgccgct ccggccgccg ctccagcacc tgccgccgct
     4801 ccagcccccg ccgccgcacc tccggccgcc gctccagcac ctgccgccgc gccggcgccc
     4861 gctgccgctc ccccggccgc ggcgcccgcg ccggctgccg caccgacacc ggccgcggca
     4921 ccagccccgg cggcacccgc acccgccgcg gcacccgccc cggccacggc acctgctccg
     4981 gccgccgcac ccgcacccgc cgccacaccg gcggcggcgc ccgctccggc tccggcacct
     5041 gctgccgcgg cacccgctcc cgcgccggca ccggcggcgg cacccgcgcc cgccaccgct
     5101 ccagcccccg cggccgctcc ggcgcccgcc accgcgccgg cgccggccgc cgcacccgcc
     5161 gccgcaccgg gagcggccac ccccggtgca ggcgctgctg ctcccggggc cggagcggcc
     5221 accccgggcg cgggaactgc cacgccgggt acaggagcgc ccgtaccggc cggcggcagc
     5281 ggcgggggcg gtgggaagac gactccgggc ggcaccggca ggaccggtgg cgcgggcgga
     5341 ggcacgggga ccgggggcgg gacgggcgcg ggggcgggag gcgggggcag aaccgggggc
     5401 ggcggtgggg gcgggacggg ggccggtgtg agggtcggcg gttcgggcgc cggcggttcg
     5461 gggagtggcg gcgggaccgg cggcggtgtg ggctcgtcca cggtgaagtg gccgatcgcc
     5521 caatccttga gcatcggcgg cggcttgggg cagccgtcgg ggccgagggt cttgatccgg
     5581 tcgctcccct tcacgcgccc cttgctgagg tagtggccgg gtggccgctc cacggtcgcc
     5641 acgcaccgcg ccgagcctcc cggttccagg ctcggtacga cgtcgccgcc ggacccgcag
     5701 acgatggcgg gcggctggag ggccgggtcg ctgagccgga ggtcgtacac cgtgcggttg
     5761 ccggtgttgg tcacgtcgta taagacggtg gcgcggccca gggtgagggc ccggcccagg
     5821 gatccggcgc cggtcgtcac cgtctcggtc agggacagcg ccccgcccac gcccgcgtac
     5881 ccggaccggg cgacggcccg ggactccgtg ccgagggagg gaacgctgcc gacggcggtg
     5941 acgtcggcga tccaggtgcc cgggcgggcg gtggcccagg ccgtgcaggt cgccgagtcc
     6001 aggccgcgga gcatcggaag gtgatcgccg ccgccggggc agcggatgtc ggcgtgcgga
     6061 aggcccgggt cgttcacccg cacgtcgtac aggtcggccc cggtgcggtt gatcaggtga
     6121 tacgtcttca ccagcgggtg gccgacgcgg atgccggggt cggtcgcccc ggtgcccggt
     6181 cgggtgttga cggcgacctg gagggcgagc ccgtggtttc ccgcgccgtc ggcgacggca
     6241 cgctgcgccg gtgcgccgca cacggccatg agcagcggca acaccgcggg aagacgtgtc
     6301 cggagggttc gcccacacct ccctggtaat cctatgaaca cacaaaaagg actaacagag
     6361 cggtccgggg gcgggcttcg gtccacgccg gtcgccgggc gcaaccgtac gaagatcact
     6421 ccggtggccg cgcgaggggc tccgcgggga cccggggccg cgcctcgggc gccgggggcg
     6481 ctcaggcgcc gggcatcagg cccgcggcga gggtggcccc cagttcccag caggcctgtg
     6541 cgccggcctt gcccgggtct ccggtgacgg tcaccggcgc ggccgcccgg cgccagccga
     6601 ggccggtggt gacggtctcg acggcgcgga cggcgccggt gacgtcgttg ccgccgtgga
     6661 cgtagaaacc gaacgggcgg ccccgggtct cgtccaggca ggggtagtag atctggtcga
     6721 agaagtgctt gagagcaccg gacatgtagc cgaggttggc gggcgtgccg agcaggtagc
     6781 cgtcggctgc gagcacgtcg gaggcggtgg ccgacagggc cgcccggcgg acgacgcgca
     6841 cgccctcgat ctccggtgcc gtggcaccgg acacgacggc ttcgaacagc gcctggcagt
     6901 gcggcgaggg ggtgtgatgg acgatcagga gggtaggcac atccggcacc ctgccgtgcg
     6961 ccggccgccc ctggcaaacg gcgggccgcg gcgggcgccg ccgaggagga cgggaggagt
     7021 cgaacgtgac cgaggaggac gggaggagtc gaacgtgacc gaggaggacg gccggccacc
     7081 ggccgccgtg gtgttcgacg cgctgggccc ggcgtacgag cgggcgttcg ccggctccgc
     7141 accgcaccgg gcgtcgctcg accggctgct ggagctgctg gcgccgggca gccgggtgct
     7201 ggacgtgggc agcggcaccg gacggcccac cgcgcagacc ctcgccgggg ccggtcaccg
     7261 ggtgctgggc ctggacgtct cgccggtcat ggtcgacctg gccgcccggc aggtgcccgc
     7321 cgccgagttc cggctcgccg acatccggga gacgccgttg gcggacgcct cgttcgacgc
     7381 cgtgtgcgcc tacttctcgc tgttgcagat gacccgcgcc gaacaggcgg cggtcgtggc
     7441 gaagctggcc cgggcggtcc ggcccggcgg cctggtcgcg ctggccaccg tgccgttgga
     7501 cgtggaggac gtcgaggccg tcttcatggg gcagccggtc cgggtgacga gcttcgccgc
     7561 cgaggcgttc accgggctgg tgtccggggc gggcctgacc gtgctgtccg aggagcacga
     7621 ggtgttcacc ccggcccatc ccgaggccgt acccgagccg cacctgttcg tgctcgcccg
     7681 gcgcggggcc gactgacccg cgggtcggtg ggcgacatca cgttcggcgt tgtcggtgct
     7741 ctcggctaca gttgccgctc cgcatcaaag gggaggcaac agtgcaggtc agggtgggga
     7801 ccgtcggagg ccgcatggtc gtcgcggcgg cgctcgccgc gatgctcggc ggctgcgcgg
     7861 ggtcggcgga cggcgacggg aagaagtccg cgggcgcgtc ggcgagcgcc gagggctcgg
     7921 cggccggggg cgcgggggcg aagggcgggg ccgcgccggc cggcgcccgg atcggcgggg
     7981 ccggttcggc ctgcgaactg cccgtcagct tccacgtcgc caagcgctgg agggccaagt
     8041 ccgtcgacgc cgagaaggag ctggccaagg cgtcgaagag cgaggacggc gacctgagcg
     8101 gggcgctcgc cgaggcgttc ctgcggcagg gaccggtcac cgcggcctgc gagatcgacg
     8161 ccaagccggc cggcaacatc ggcttcctgc gcgtgtggac gggcaagccc ggcgagcccg
     8221 gcacggcctc ggcggacagc gtgctgcgcg ccttcgtcgc cgccgaggac aacgtcagca
     8281 aggagaagta ccgctccgtc aggaccggcg gcggcctcga cgccgtcgag gtggagtacc
     8341 tgtacacgag caagctcctg gaggagacga agaaggagcg cgccctcgcc gtcagcacgc
     8401 cccagggctc ggtcgtcctg cacctcggcg ggatggacac ccaggagcac gaggagatgc
     8461 tgcccgcgta cgagctggcc aagcagaccc tcatgctctc ctgagcccgt cgccccgtcg
     8521 gtccgccgtc gtggcccggc ccaggtaggt gagcgggccc gcgtccacga ccgggatctc
     8581 gtggaagccg acccggtcgt agaaggcgcg ggcggcggtg ttgacggtga ccatgccgag
     8641 gtggaccgcc tggacgccct gtccgtgcag ggcgtccagg aaggtgcgca tcaagcggcg
     8701 gccgtagccc cgcccctgcc agggcggcag caggtcgatg tgcaggtggg cgggataggc
     8761 ggcgagttcg gggacgagca tccgctccgg gtggtgcagg aggcggatca tctcctcggt
     8821 gggcgtgcgg ggcggtaggg ccggctccgg gtagcggccg gccagtcgcg ggatccaggt
     8881 ccgccggaag ttctcgacga agcgcccggt gtcggccgtg ccgacgatgt agcccacggc
     8941 ccggcccgtg ccgtcgtcca ggacgaaggc cagctccggc tcgaagtggc agtacggctc
     9001 cgcgaagagc gagggcatga ggcgctggtc ggggtagatc gcccgggagt cgcctccgtt
     9061 gtgcgcggtg cggacacaga cgtcggccac ggcttcgcgg tcggcggggt ggtaggggcg
     9121 tatcacggca gtccggtcgt gagtcggcat acccgcatcc tcgccttttt gggagcgctc
     9181 ccacaaggtc ggtcacgcgg gtggatgagc catttccgga ccttcgcgct ccgcatgccg
     9241 gccccccgtc cgcccgcccc cgacgggcct ccgggacctg cgaccgactc ccccgttccg
     9301 catgtggccg acgagggtgg cgacatcagg gcgtactgac cagaagtatc cgaacagaca
     9361 cccacggcga cctgatgacg tgtcgaagaa gcggaatgcg gcgatcctcg caacgcggca
     9421 acgagttcca actccggtcg cactccgcgc agttggaact ccggtttcgt ccagacatcg
     9481 cccaccgaca aggagctccg tatgagcacg ccgacgcagg actcgtcctt ccgcatcacc
     9541 agcgccccga acatcaccta cgcgcagtgg gacaccgagc gcttcgagac caccagcacc
     9601 gcatggaccg cgctgccggg cgcgtcgatc gacctccgcc tgggacaggg ggcgccctcg
     9661 tacggcgcga tcttcgtggc caccttctcg gccgaggtgc tctcctccga ccagggcggc
     9721 gacgggcagg gcctgctggc cgcgaccgtc ttcttcggcg acgagcaggc cgaaccgctc
     9781 agcaacaacc accgttacgt caccgcccgc ggcaacccgg agtggtccag ccacaccttc
     9841 atccgcgtgg cccgcttcga gcccgaattc gcggtccgcc aggtcaacgc gcaggtgaag
     9901 ctgcgtgtga gcaacgcgga ctcgggcggc gtccagaact gggtgctgaa gatcgagcgc
     9961 tacaacctct gaccgcccgc ccggtccggc cgcgagcacc tcactcgcgg ccggaccggg
    10021 ggcgacaggc gctgagggcg agcaggaccc agatgtcggc gagggccggg acgtcgtaca
    10081 gcaggggccg ggggcccgcc tggtcggtgc ggctggcgta gccgccatcg ggctgctgcg
    10141 cggccagcag gcagccgagg gcccggtgca gggcgggggc ggcggacgcg ggtgcggcgg
    10201 cgagggcgac ggtcgcgtag gcggtgctga tggggtcgct ggtgtcgccg ggttcatgcc
    10261 cccagccgcc gtcgggctcc tgggtctccg tgaggtagcg gatcgcgcgc tgccgggccg
    10321 cgcgggccgc ggcgcgcagg ggggcgggcg cgctgggggt gagggtggcg agggccaggg
    10381 tgacgcggaa gagggcgttg gtggcgttgc ggctccagct gcgttcgacg aggtggtcgg
    10441 cttcgaggag gaaggcgacg gcgcgttcga cgtcggggcg gcgtgccggg ttgggcgcga
    10501 gcgcgttgac ggcgccggcg gtcatcgcga tctcggaggg ggctccgtgg acgaaggtgg
    10561 ggaagccccc gtcggggttg cgctgggcga ggaggtactc ctcggccgcg gtgatggtgc
    10621 gggcgtgccg gacgggggcc gcggcgcgga ggaactcgag ggtgtacgag gtgtcgtcga
    10681 cgtcgctctg ggtcacgccg acggtgaagc cgaagccgcc gtccgggttc tgccgggcgg
    10741 ccagggcgtc ggccgtcgcc gcgaggcggg ggtcgagggg gcgggtccgg gtgagggcga
    10801 taccggcgac ggcactggcg aagacgtcca tcccggtgac gaacggaagt ccgccgcccg
    10861 gctgttgatc ggcggagatg cgcaacaggg cctcacggac ggcgggttga tgggtggggt
    10921 gtttgcgcag ggcgagcagg gccacgaggc gggccaggtg gttcgcctgc cagggcggcc
    10981 ccgggcggag ggcgagggcc aggcgggacc agtcgtcgct cgtggccgca cggggggcgg
    11041 tgatggtctt gagggcgagc atctgcagtt gcagccacgc ctgttggccg tgcgcgtcga
    11101 aggcgtcggc gggcaggtcc cggcggtggg cgccgtcggt gatctcggtg agcagggtct
    11161 ggaaggtgag cagcttgcgt ggggtgctga agtggtcgaa ggaggcgagg gcgtcgcgga
    11221 cggtggtgct cccggtcagg gcgtcgccga gggccacgtg ggcgaacgcg cactggaggg
    11281 cgtcgggcgg atcggtgtcc agggtgtgct tgaggtaacg gcgggtcaga tcggctgccg
    11341 cgggggcgag gtcctccttg gtgagcaggg ccagcaggag ggcggactcc aggacacggc
    11401 tgctaccggg ggccgggatc aggccgttgg gcccgatgcg ctccaggacg cggcgggcga
    11461 ggcgggcacg gcgggcgggg aggtgggggt gcaacggggg tgctccggac ggtgggtggg
    11521 gtcagccgaa gagccggtga aggacgtggc ggccgcaggg cacgacgggg cggggagggg
    11581 cggcgaggaa cgccgcgatg ggccacaggt cgtggtgggc gatctcggcc gggtcggggg
    11641 ccgggggcgc gaccaggcgg gcggtgtgga cggcgagatg gcaggggccg acgggcgagg
    11701 ggcggcggag gcggagcgct tcgacggggt cggtgcggat gccgagttcc tcggccagtt
    11761 cacgccgggc ggcctgccgg taggtctcgc ccgccctgac cgatccgccg atcaggacgt
    11821 cgtggtggtc cgggtagacg gcggccgtgg acgggcggcg gtagaccagg acgtgcccgg
    11881 gaccggccag gaggacggtg gcggcgacgc ggtagtacag gccggcggca ccggcctggc
    11941 cgcgccggcc gcggcggacg aaacgatcgc tgccgtcgac gaagtcgatc acctctgcgc
    12001 tgtgcacgag ttccgctcca tgatcaacca acagggcagg tcgctcacag tagtacacct
    12061 gtcacgcatg gctatcatga ggcgggttcg caccgtaccg agcaggaggc cgacttggcc
    12121 acagcaccgc ccgccaccgc agtcccggag ttgcctcagg ccgaagtcgc ccgatggcgg
    12181 gcggccggcg caccgctcat cgacctgctc acccgcgctc accggctcgg ccccgtcagc
    12241 ggcgtccccc tcgccgaccg gcccatggtg ctcgtcacgg acccggccgc cgtccaccat
    12301 gtcctggccc tccacccgga ccgctacgtc aagcgctcac accgcatgag gcatctgctc
    12361 ggcgacggca tcatcaccgt cgacggcaca ccgtggcgcc ggcagcggcg cctgctccag
    12421 ccccagttca ccgtccaggg agtccaccgc tacgagcggc tgatgcgcga cgccgccgcc
    12481 cacaccgccc gggcctgggc cgacagcgcg cgcaccggcc gacccaggga cctggccgcc
    12541 gacatgcggc gcttctccct cgacgtcatc tggcgcgcca cgaccggcca ggccctcgac
    12601 gacaccacgc accggcagtt cctcgccgcg ggacgcatcg tcgccgcgac cgccgcgctc
    12661 ggcccctcga ccggaaccac cgctccggac ctcgtcgacg accacgccga cgtggaggcc
    12721 gtcaccgcac gtgccatcgc cgccgcccgc gccacccgca cccccagcct cctcgacgcc
    12781 ctgctcggcg ccgccgaact ccccgacggt gacgggcgct tggtccgcga caacttcgtc
    12841 acctttctcg tcgccggcta cgagaccacc gccgccaccc tcagctggct cctgctgctc
    12901 ctgcacgaca accccgaccg gcgcgcctgg gcgctggccc gcgggccggc cggatcgccc
    12961 gcccgcaccg cggcgatccg cgcgctgatc ggtgaaaccc tcaggctcta ccccaccgcc
    13021 tggctcctgc tccgccaggc cgcccgggac gacgtcctcg ccggccaccg cgtcgcggcc
    13081 gggaccaccg tggccgtctg cccctacctc acccaccggg acccgcgcct gtgggcggac
    13141 cccggcctgt tccgccccca gcggttcgtc gacccgccgc agcgccccgc cctgggcacg
    13201 tactacccgt tcggcctcgg cccgcgcgcc tgcctgggag cccagttcgg gctccgcgag
    13261 atggccgtcc tggcggaaac cctgctgccc gccttcgact tcgccctcac caccgccccg
    13321 cccgggcccg tcttcgacct caccgtccgc cccgacggcc ccctcgtcgc gaccgtcacc
    13381 gcacggaacg cccgcggctg acctgctcgg ggccggcgtg cgcgggcgtg tctcgtcgcg
    13441 tggcggtggt cagtagcgca gacgcctggc cctgaggaac atgaacaggc ccgacagggc
    13501 gagcagcgtg ccgacggccg cgggccacag ctgggccccc gtctccgcca ggctgcctcc
    13561 ggcggcccga ggcgcggatg gcgcggccgg cggcggggcg tacgcggcgg cggtggtccg
    13621 gcccggcgcg cccggcgcgg cggaggcggg cgcggacggg gacggggacg gggacgacgg
    13681 tgtcggccgg gccgacgtcg aacgcaccgg tgtggagcgg ggttcgacgg gctcggccgg
    13741 tgcggccccg tcatccgtgt cgcgcttggc ggtgcgggca ggggaggccg tcacgtcatg
    13801 tcgccgagcc tcgccggtac gcgcggccga gggcgtcggc gcggaggtgc cggtctcggc
    13861 gggctgccgg ccggcgccgt cgccgggggc gggcgtggcg ccggatcccg gactcgccgg
    13921 gggcgtcgcc gtcgtaccgg agtcaccgcc ggaagggccg cacgtacggc cggagttgat
    13981 gcagtcgacc atctcgcgca tcaggtcctc gtcgaagacg ttgatgaagt cgccgtggtc
    14041 ggtgacgggc ttgtgcaact gctcggggaa ggagtccacc gcgaacagcg gaacggtccg
    14101 gccgccgtcc gccaggctcg gtgcgtcgac gtcgtagacg atgcgctgca ccagctgcgg
    14161 gatgggccgg aagcccgcgg ggcaggagcc gtcgggggcc gcgaaggcca cgtgggtgcg
    14221 gtggttggcg ctgtcgatgt tgcggccgtc ccagcagctc tggaaccgga aggtgcgcac
    14281 gacgtcgctg cccggcgggc acagggggta cttgtccttc agctgccggt cctcgtgacc
    14341 ggtgcagctc caggaggcgt tggcgttgcc gggcccgttg acgaaggcct tggcgtcgcc
    14401 ggtgatgatg cgcagcaggc gcggcatggc ggtgacctcg ccgagcgggt tgccgacgaa
    14461 ggtcagcgtc acctgccggg gcgtcacgat ctggccggcg ttgccctccg taccgccgcc
    14521 cggggcgccg gcgtcccgct cctgggtgcc gttctgcagg cgcagcaccg gccagtagta
    14581 cgacgacttg tcgccctggt cgacacagct cgtgccggcc cgcgccaggt cctcgtcgct
    14641 cgcgaaggcg ttgttggcct ggttgccgac gtagtcgtgg acgtggtggg cgccgttgga
    14701 gacgccgggg gcgacgatga cgttgtcgga gttgaacaga ccgttcgcgt tgactccgca
    14761 gtcggtggtg aaggtgccgc gtgaggcacc ggcctgcggc tgcggagccg gtgcctcggg
    14821 cggtacggcg gtgatgtcgg cgtagtcgga ggcgacgggt ccgttgccgc cctgacccgc
    14881 gccgctctgc ccttggcccg tgccgctctg ctcctggccg gtgccgctct gctcctggcc
    14941 ggtgccgttc cgcccgtcgc cgtcgcccgg gacgccggtg gcctggccgg tctcaccggg
    15001 gcgcaaggtg caggcggcca gcgactccag gccctgcggg cgctccccgg cccggtcgat
    15061 ggcgtcggtg atccgcccga tggacaccga ccgcttctcc tccagcgggt tcatgatccc
    15121 gtcgtcggcc gacgccgcgt ccgcgccgcc gccctgtccc gcctgctgga gctgccggta
    15181 ggccgccgcc gtctgctggt cgagccgggc gagttcgcgg tcgacgtccg ggcgggccgc
    15241 gtccggcacg gccgtcagcc ggctgccgat gtcggggcag tcgatggtgg ccatgcccgt
    15301 ggaccggacg cgcccggtgg tctccgtgcc ggatccgtcg ccccagccct cgccggccga
    15361 ggcgtagacg ttcaccgcga cgagtccggc tccgcccagc atcagggcga tcgccgcacg
    15421 ggtcgcgcgt cgagggccgg tcgggcgtct gcggctgttg cgtaccaagg tcgtccccct
    15481 gcgtggtcgc cggtcgggca tggagttccc cggcttcata cggagggcgg ggccaccgtg
    15541 ttcaacggaa acgggaattc accgggatct cacaggaaac cacggcctcc cctcttcccc
    15601 gtcgaacgtc atcgcgaaca tcacgaatat gtatcggaca tttcacacct caaccttcac
    15661 acgaggtaca cacgttggct aggttgacgc ctggccgccg cccggctctg ccccggcgag
    15721 ccgctcaact gccctgcggg gcaaggaagg agcacgtcct ccatggcgcc ggagagccgc
    15781 gacgaggttc ggcagcggat cgcatccctc tacgaccagg ccgagaacgc caccggaaac
    15841 ttcaacgcga cccgggcgat ggccgcccgg agccggtccc ggggcgtccc gctcgccaag
    15901 cggccgggcc ggcgcccgga tcccgaactg gccgaggtgg cccggcagtg gttcgacgcg
    15961 gcacgcgcca agctcggccc gacggtcccc gccgcgctgc ccgccgaccg gctcctggac
    16021 ggacccgccg cccccgcgcg ttcaccggag cggacgggcg gtcttcccgg cgccgagcgg
    16081 gaggtacgcg ctcttccggt gggtggcggg gccctcggcc tgacgagcgg cggacagagc
    16141 ctcggccttc cgggcggcgg agaggccctc ggccttccgg gcggcggagg aagcctcgga
    16201 cttacggacg gcggagaagg tctcagtctt ccgggcggcg gcagggacgt cctcgccctg
    16261 ccgggtggcg agcggcagaa tccgggggac ggcggtccgt ccgcacggca tcccgaggcc
    16321 ctcgaacggg gcgcagcgca ggcggtggcc gagctgacgg cagcttcacc ggcggactcc
    16381 gccggccgcc cgccgcagtc gcccgagacc ggccggccgg cgcttgccgg tgccgaccgt
    16441 ctcgaaccag caggcaccgc actggcgttg accggcgggg cggcggccga accggccggc
    16501 tggggcgcgc cggggccggc gagcaccgcc gccctgccgg ccgccgcgcc ccccaccgcg
    16561 cagggcaccg cagctcagcc cagaccgctg cccggttccg ccgcgtccgg tcgcccctcc
    16621 cccgcagcct ccaaggccgg caaccgacgc aagctcgacg cggcacgcga cctgctgtcc
    16681 cggcacaccg gccggctcac cctgtccggc gcggccggcc tgcccgcctg ggccgccggg
    16741 ttcgagcagg tcccgcacgc caccactgcc gagacgacgc ccccgtggca agacccgcag
    16801 tggacggcat ccgctccggc atccgctccg gcacccgcgc ggtcgacacc ggcgacgccg
    16861 gccgtagcca cccgacccgt cggcatcacc gcacccgcga ccgacaccgg ttccctcccc
    16921 gcactcaccg acaccgggcc cttcagcccc ctgacgggca ccggacctct cagcccgctg
    16981 acggacaccg gatccctggc cccgctgacc gacaccggat ccctaccccc gctcaccggc
    17041 accggatcct tcgccgcccc caccgccgcc accggatcca cccccctgcc cctccccggg
    17101 cccgcagccg ccccggagtc gccacgcgcc ctgcgagccg ccaaggccat cgcgttcgcc
    17161 cgggcgcaga tcgggaagcc gtgcgtctgg ggggcgagcg ggccggattc gtacgactgc
    17221 tccggcctca cccaggtcgc gtggcgggcg gccggtgtca cgctgccgcg tacggcgcac
    17281 cagcaggcgc tggccggtac cccggtgacg ctcgccggca tcgagcccgg tgacctcgtc
    17341 ctcttcttcg acgacgaccg gcatgtgggt ctgcacgtcg gcgacggcat gatggtccac
    17401 gccccgggac cgggctcgtc cgtccgcgag gagtcgatct acggcgccgg tgaggcggcg
    17461 atccaccgga tcgtccggcc ggcctgaccg gggtcggccc cggcgtcgac gggcgcccct
    17521 gcgctcggaa agcccaccgg ccggtgcggg agtgcggcat gcggcacgcg gcacgcggca
    17581 cgcggcagcc aagggtcgcg tgagcctccc ccgccggccc gtacgccgcc cggcggggcc
    17641 cgcataagca acccctggga aacccataag atcggcttat gaggtcatag acgagacccc
    17701 ggtaccaact taggtctgcc ttagtttagg cttcgtgatc aagtcgccca ttcacgctcg
    17761 aagggaacct gatcatgccg cgccccctgc gggtagccat cgtcggagcc ggccccgccg
    17821 ggatctacgc cgccgacgcc ctgctcaagt ccgaggtggc cgccgacccc ggtgtgtcca
    17881 tcgacctctt cgagcggatg cccgccccgt tcggcctgat ccggtacggt gtcgcgcccg
    17941 accacccgcg catcaagggc atcatcaccg ccctgcacca ggtcctggac aagccgcaga
    18001 tccgcctgtt cggcaacgtc gactacccga ccgacatcag cctggacgac ctgcgcgcct
    18061 tctacgacgc ggtgatcttc tccaccggcg cgatggccga ccgcgaactg cccatacccg
    18121 gcatcgacct ggacggctcc tacggcgccg ccgacttcgt ctcctggtac gacggccacc
    18181 cggacgtgcc gcggacctgg ccgctggagg ccgagaaggt cgccgtgctc ggcgtcggca
    18241 acgtcgccct ggacgtcgcc cgcatcctcg ccaagaccgc cgacgagctg ctgccgaccg
    18301 agatcccgcc gaacgtctac gacggcctga aggccaacaa ggccgtggag atccacgtct
    18361 tcggccgccg tggcccggcg caggcgaagt tcagcccgat ggagctgcgc gagctggacc
    18421 actccccgaa catcgaggtc atcgtcgacc ccgaggacat cgactacgac gagggctcga
    18481 tcgagacccg gcgcggcaac aagcaggccg acatggtcgc caagacgctg gagaactggg
    18541 cgatccggga cgtcggcaac cgcccgcaca agctgttcct gcacttcttc gagtcgcccg
    18601 tggagatcct cggcgaggac ggcaaggtcg tcggcctgcg caccgagcgc accgccctgg
    18661 acggcaccgg caacgtcaag ggcaccggcg agttcaagga ctgggacgtc acggccgtct
    18721 accgcgcggt cggctacctc tccgagaagc tgcccaagct gccctgggac atcgactccg
    18781 ggaccgtccc cgacgagggc ggccgggtga tcgaggaggg cggcacccac ctgcagtcca
    18841 cctatgtcac cggctggatc cggcgcggcc ccgtcggtct catcggccac accaagggcg
    18901 acgccaacga gaccgtggcc aacctgctgg acgactacgc gggcggccgg ctgcacaccc
    18961 cggcgacgcc cgagccggag gccgtggacg ccttcctcgc cgagcggaac atccgcttca
    19021 ccacctggga gggctggtac aagctggacg ccgccgagcg tgccctgggc gagccgcagg
    19081 gccgtgaccg cgtgaagatc gtcgagcgtg aggacatgct gcgggagagc ggggcgtaag
    19141 gtccctcctt ccttcgggtc cccgggggcc ggcgccggtg cgccggcccc cgctgccgtt
    19201 caggcccgcg ccgcccgggc gaacagctcg tgcagcggca ccggtgacag cagccgggtg
    19261 aaggggccgg acacgccctt gcccgcccgg accgcgccgt acgtgctcaa cttcccggcc
    19321 tccaccggca gatggggtgc gtcgagggtc tcccaggtgt cgtgggcgaa ggccgtgcgt
    19381 ccggcccggg cccgccgccc ggtctccacc gcccccaccg ccaccagctc cgtctgcgcc
    19441 gccttgtgcc gggcggccgt ccagccgttc cagcggcgga cgttgcggtc cgtgggccgg
    19501 gccagcgcgc acagctggag gtggagcgcg gcggcgtccg taccgacacc gagccgccgc
    19561 gcgacctcgg cgaccagatc cggggcgctg agcacggggt tggcctcgta gccgcccgcg
    19621 gggacgggtg tcccggcggc gcgggccgcc atccgggcca gaccgtcgag cagcgcccgc
    19681 agccccgtga tctcctcccg cagccggggc agccccagcc ggtcgctcag ctccagcgcc
    19741 cgggccaccc gctgcggttc cgcgagggcg gcggtccgca ggaagacgtc cccgctgggg
    19801 accgcgacga cgagcgtccc gtcgtcccgt gccgtgaggg cctccgggac ggtgtccagc
    19861 agcggttccg ggcaggggat cacggtgccc gcgcagggcc ggaaggccgg gtcctcggcg
    19921 gcggcccggg ccagcgccgg agacggcagc agctcgacca gcgtgtccgg ggcggcgaac
    19981 catgcccgca ggcgctcgta cagtcgcagc gccccctcgg ccgcgggatc gccgaccggc
    20041 cgctcggtga gggcccaggc gatcacggtc agcgtctccg tgtgcggggc ccggtcccgg
    20101 cgtatccacg cgcccgccgt gccgtccggt cctgtctggt gcaggtggag ccggccggtg
    20161 cggctgccga ccaggacgtg tccgcccggt tcggccggcg ggcggccgga ggacagggcg
    20221 cgggcccagt cggcgctcag gcccaggtcc gcctccagcg cgtccgccag ctcctcgtcg
    20281 acgtagggcc gcgtgccgag cagctcggcc cagacggccg ccatgcgttc cgcggcccgg
    20341 acgagtccgt ccgccgtcca caggtcggcc gggtcgtccg ggaccccggc ggcgagcagg
    20401 gcgcgccgtc cgtgggggcc gagccggcgc cagaagtcgt cgtactctgc ggccgtgctc
    20461 ctgttcgcct tgtaggggcg ggaacgcagc attctggcgt ggtcgtcgtg cccggtgcgg
    20521 cgcgggagcc cggccagggc cagggtggcg acggggcgtc gtactccggt gcgccaggag
    20581 aagacggcca gggcctccgg ggtcaacggg accggtccgt tctcctcgac cagctccacc
    20641 aggcgggtca ggcgtgcggc gtcgtcccgg gtgacggtga cggtctgctc ctcctcggtg
    20701 cgggccgggg cggccgccgt ggccggctgg acgaagcggc ggagtccgcc gcgcgcgggg
    20761 cccgccgccg tgtccgggac ggcggccggc tcctccagcg gggcccggcc ggtgcgccag
    20821 gtgccgccgg gttcggcgaa gggctgccgg ctccaggtcc gcagcagggc gttcagcgcg
    20881 gtgcgctcgg cctcggatgt ggtctcgacg gcggcccgcc aggcgacggc gtcgatccgg
    20941 ccgagcagca cctgccattc cgcggggcgt gccggcgggg ccaggctgcg ggtctcgtcg
    21001 tcgatctcgc cgcgcaggaa ccggccgtcg gcggccaggg cggtgagggt gccggcgtgc
    21061 cgttcgggtg cgtggtcctc gtaggcgcgc aggtcgggca ggagtcccga cagggcgggg
    21121 acgagggcgg tgtcggggat gtcggcgggg agggtgacga ccgggcccga gcgcatgatg
    21181 ccgacgcgcc gggacagctc cgcacggcgg cgcagcacgt cggccgcgag ccgggccgcg
    21241 cgcaccacgc cgtcccgcac gcgggcgtcg ccggcctcgg gcagcagccg ggtgacgtgg
    21301 gcgcgcaggg cctcgtcgtc ccgggtgtcg cgggcggcgt cgaggagggc gcgcacggtg
    21361 gcgtcgcaga cggtgcgcag cgccttggag gagcgttcgt cgcgcggggt gaggaagtgc
    21421 cagaacgcgg gcggcggcac ggggccggcc gcctcgccga gggtgggcgg acggtcgcgg
    21481 tcgcgtccgg aggg
//
