LOCUS       NZ_AP024135            21245 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces sp. EAS-AB2608 strain NBRC 114648 chromosome.
ACCESSION   NZ_AP024135
VERSION     NZ_AP024135.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. EAS-AB2608
  ORGANISM  Streptomyces sp. EAS-AB2608
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shin-Ya,K.
  TITLE     Identification of functional cytochrome P450 and ferredoxin from
            Streptomyces sp. EAS-AB2608 by transcriptional analysis and their
            heterologous expression
  JOURNAL   Appl Microbiol Biotechnol 105 (10), 4177-4187 (2021)
   PUBMED   33944982
  REMARK    DOI:10.1007/s00253-021-11304-z
REFERENCE   2  (bases 1 to 9320785)
  AUTHORS   Okubo,S., Ena,E., Okuda,A., Kozone,I., Hashimoto,J., Nishitsuji,Y.,
            Fujie,M., Satoh,N., Ikeda,H. and Shinya,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2020) Contact:Shinya Okubo Eisai Co., Ltd.;
            Tokodai 5-1-3, Tsukuba 300-2635, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Coverage                   :: 53x
            Sequencing Technology             :: Miseq; PacBio RS II
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019703895.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:16:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,174
            CDSs (total)                      :: 8,084
            Genes (coding)                    :: 7,890
            CDSs (with protein)               :: 7,890
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 87 of 194
            Pseudo Genes (incomplete)         :: 132 of 194
            Pseudo Genes (internal stop)      :: 10 of 194
            Pseudo Genes (multiple problems)  :: 32 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:41:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 567200
            Orig. end                         :: 588445
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP024135.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21245
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="5"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21245
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21245
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11245](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11245)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    201..216
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            complement(544..936)
                     /locus_tag="K6K39_RS02350"
                     /old_locus_tag="EASAB2608_00505"
     CDS             complement(544..936)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676850.1"
                     /locus_tag="K6K39_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00505"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_059247126.1"
                     /transl_table=11
                     /translation="MAAEQNHDSAACKRVDQGITRVFQLLGKRWSGPIVAVLVEQPAYF
                     ADLRRAIPGISERMLSDRLAELGAAGLVLREVDEGPPLRVSYRLTEAGAALEPALRELA
                     EWAKAHLPEASAFPETSLERPAGVHG"
     gene            1064..1714
                     /locus_tag="K6K39_RS02355"
                     /old_locus_tag="EASAB2608_00506"
     CDS             1064..1714
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073540.1"
                     /locus_tag="K6K39_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00506"
                     /product="FMN-dependent NADH-azoreductase"
                     /protein_id="WP_059247125.1"
                     /transl_table=11
                     /translation="MATLLHIDSSVFPTEASASRAVTEAFRKHWEEQHPQGTVIYRDLA
                     VDPVPHITADAHLAGFVPPTAHTPEQAAVFAERVKLIEELEQADAILIGAPMYNYTIPS
                     TLKAWLDNIILMGRTAGENPSAKGTPVTVVASRGGSYAPGTPREGYEYVQTYLKAVLAD
                     ALGLDLEFIVPELTMASKNPAMSELVPLYEASRDRAFEAAEARARQLAERLAA"
     gene            1941..2621
                     /locus_tag="K6K39_RS02360"
                     /old_locus_tag="EASAB2608_00507"
     CDS             1941..2621
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117284.1"
                     /locus_tag="K6K39_RS02360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00507"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_059247124.1"
                     /transl_table=11
                     /translation="MSTAHTTSPARTLRAAYEAASAVVAGLGDEESWLPTGCTGWAVRD
                     LVFHCLHDAQRGLVALHTPADAPVDRDAVTYWQDWRPDTAGAANGRRWARVNGSMFLVF
                     GQLQELYLETLAAAVHAADSVDPARRVATQGHVLTAGDLITTLAVEATVHHLDLTVRLP
                     LAPGPSPEGLAAVRATLDGLLGGPAPAEWSDERYARVGTGRAALTDTERAALGAAADRL
                     PLFG"
     misc_feature    complement(2670..2684)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 27.18"
                     /tool="antismash"
     misc_feature    2671..2685
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.37"
                     /tool="antismash"
     gene            2773..3054
                     /locus_tag="K6K39_RS02365"
                     /old_locus_tag="EASAB2608_00508"
     CDS             2773..3054
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676842.1"
                     /locus_tag="K6K39_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00508"
                     /product="hypothetical protein"
                     /protein_id="WP_059247123.1"
                     /transl_table=11
                     /translation="MNTPPSINSYVDRVTAGPGGAMTDEVGVITGDLTVATILLSDGRS
                     VRVAVQHSGSDTWYTLAGSPAPVPAGQLAAYHRDLLGRIRRGGGTRAT"
     gene            3225..3962
                     /locus_tag="K6K39_RS02370"
                     /old_locus_tag="EASAB2608_00509"
     CDS             3225..3962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824320.1"
                     /locus_tag="K6K39_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00509"
                     /product="YqjF family protein"
                     /protein_id="WP_223283680.1"
                     /transl_table=11
                     /translation="MVSYGPQQRVYVPELRADWLTQSFVHWAYSPAQIQLLLPRGLAVD
                     TYDGSAWVSLTPFVMAGVRPPGSPAALPPFAETNLRTYVRGPDGRDGLWFLSIEVACPV
                     MLAARAMGVPYRLGRLALARHGDTVAYTGVRWGGGPRYRLVVRPGEPVRPSRLDVWLTS
                     RWRAFTLRWGVLWETPVEHAPWPLRETRLEAMEETLTRAAGLPPPVARPIVHFSDGVRN
                     VRLGVSRPVRRRGRVRDRAAPGG"
     gene            3959..>4579
                     /locus_tag="K6K39_RS02375"
                     /pseudo=""
     CDS             3959..>4579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823588.1"
                     /locus_tag="K6K39_RS02375"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNAPAPGPARLRFDGWIAGIGTASGTRVVLGHWPCSPFGPFSDVM
                     LEREDGHRLLLAPTRRTAEFIAGTYAFDEVRIVPVRVHVTGDRWTVTAGSLLDLRLTVG
                     RRSLPGLALRAVPGALAARPGWTRVTDPPARVLLGVRTRGSAGGGRREWYGARDLHRIT
                     AASAVHEGRDLGPLAPVEPAVRFGFGSAPRTPSLVRVTTTVGAP"
     gene            4643..5194
                     /locus_tag="K6K39_RS02380"
     CDS             4643..5194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009305921.1"
                     /locus_tag="K6K39_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_079081270.1"
                     /transl_table=11
                     /translation="MNGPAQPGTPGPESTGGTDMKLLGVYLNDHLAGATAGAQRIGHLA
                     RTMRGSALGRALGPVAAEIDEDRATLLAIMRNLGVPVRHYKVWAGWAAEKAARLKGNGR
                     LVRRSPLSTLLELEALRLGVEGKAAVWSTLRRLASTDERLDAALLDTLLDRAARQQDTV
                     EEWRGRAAEAALRPTARAAA"
     gene            5334..6215
                     /locus_tag="K6K39_RS02385"
                     /old_locus_tag="EASAB2608_00511"
     CDS             5334..6215
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676839.1"
                     /locus_tag="K6K39_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00511"
                     /product="DMT family transporter"
                     /protein_id="WP_059247121.1"
                     /transl_table=11
                     /translation="MIELAAAFAVAGAASSAVGTACQRKAASASSRGGVRLLAELVRRP
                     VWMIGMAGVICAAVFQSLALVNGPLALVQPLFVLELPFALLVAAPLMHRRLPRSGWWGV
                     GGCVGGLAVLLVAAAPHGATHHAPLDRWIPAVCLCVGVMAAAVLLAGRGHPPARRAAFL
                     AAASATGNALTAALLKSAAGTFADQGFTAFLRSWQTYGFALAGVCAVLLLENALQAGPL
                     AAAQPALTIGDAVVSLALAVTLFDERIRTGWWLVPEACGALLIVLGVLVLSRAVQRIVV
                     PPLPAEERNPAA"
     gene            complement(6222..6665)
                     /locus_tag="K6K39_RS02390"
                     /old_locus_tag="EASAB2608_00512"
     CDS             complement(6222..6665)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982494.1"
                     /locus_tag="K6K39_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00512"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_059247120.1"
                     /transl_table=11
                     /translation="MSHRAANLPQLLSEARRWFEDALFASMEAAGEQPVTTAQASVFAL
                     LDTEGTTVSELARRIGVTRQTVHQAVHGLIGMGLLEQVPDPGSARRRLIRTTAEGQRVH
                     ERAQATIKVIESVLTERIGPAPARALRDALTSDWGEPPLVAAP"
     gene            complement(6695..7639)
                     /locus_tag="K6K39_RS02395"
                     /old_locus_tag="EASAB2608_00513"
     CDS             complement(6695..7639)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469336.1"
                     /locus_tag="K6K39_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00513"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_059247119.1"
                     /sec_met_domain="PF00561 (E-value: 9.4e-05, bitscore: 21.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.4e-15, bitscore:
                     54.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERAVPDRHRGPDFPREFLAPPDPVRLPLPAPARPAPGVRLLRG
                     AVYAVPDGSRPLEADLWLPEPARGPVPVVVFVHGGGWRTGLRDDLGPRFRHWRPGPFAR
                     LARSGPAVVCPDYRLSGEARHPAQLDDLRALLTWLRDRAGDLGLDPERVVLWGESAGGH
                     LAALTALTTPQGPGGAATVRGCVTWYAPTDLTRLADDHAPGRFDPYDPATFEALLLGAA
                     PAAAPGPARDASPALRVTPQAPPFLVLHGTGDELVPCAQSERLTAALRAARVPVDHVRV
                     AGANHLWAGLAEEEVERCFDRTAAFVARHCAGG"
     gene            complement(7647..8618)
                     /locus_tag="K6K39_RS02400"
                     /old_locus_tag="EASAB2608_00514"
     CDS             complement(7647..8618)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980084.1"
                     /locus_tag="K6K39_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00514"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_059247118.1"
                     /transl_table=11
                     /translation="MTTPADRPGLVDVHAHFVTESYVRQARAAGHERPDGMPAWPAWSA
                     RAHLELMDRSGIDTAVLSVSSPGVSFGAPAAARALAREVNEDGAGIVRDHPGRFGLFAS
                     LPLPDVDGALAEIAYAFDQLHADGVVLETHSHGVYLGDPRLEPVFAELNRRRAVVFVHP
                     TSPVCWEQSALGRPRPMVEFVFDTARSVTDLLFAGTLERHPDLKVIVPHCGGALPVLAD
                     RINGFMRLFPPGEAEAPDAVAQLRRLYYDTAGPAFPRQVPALLGLADPDRLLYGSDYCW
                     TPAEAAEAHAASFDTAPAPAPGTSWRSLTTANARTLFPRLAR"
     gene            complement(8741..9205)
                     /locus_tag="K6K39_RS02405"
                     /old_locus_tag="EASAB2608_00516"
     CDS             complement(8741..9205)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018891.5"
                     /locus_tag="K6K39_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00516"
                     /product="DUF1427 family protein"
                     /protein_id="WP_063808492.1"
                     /transl_table=11
                     /translation="MRPPTGARRAAVAAFLRAAAPAFAAGALMGAVYWSLGLRSPAPPL
                     LGLTGLLGIVIGERAVSALRRRGRAAGSASVVGPASVVGAAPAPGPAPVVGAAPAPGPT
                     PAPGTGRRDGGTGGRDGGAGPGSASAGPGAPHPAGEHPPMVTPADDHPRR"
     gene            complement(9202..9348)
                     /locus_tag="K6K39_RS02410"
                     /old_locus_tag="EASAB2608_00517"
     CDS             complement(9202..9348)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03510.1"
                     /locus_tag="K6K39_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00517"
                     /product="DUF1427 family protein"
                     /protein_id="WP_079081269.1"
                     /transl_table=11
                     /translation="MPYVEALSAGVLVGALYALLRVGSPAPPPVALFGLLGMLLGQTLP
                     ETW"
     gene            complement(9354..9914)
                     /locus_tag="K6K39_RS02415"
                     /old_locus_tag="EASAB2608_00518"
     CDS             complement(9354..9914)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324409.1"
                     /locus_tag="K6K39_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00518"
                     /product="quercetin 2,3-dioxygenase"
                     /protein_id="WP_059247117.1"
                     /transl_table=11
                     /translation="MTIEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLVTIYAG
                     GEQTENTFNFFTCEGPKGELIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPG
                     DFGFVPKNCTHAYRMERHHSQVVGVAAGPGGTFERFFETLGTPADELGLPARPFVPAPE
                     KFATVPGQYDVRFLPDHQWRTGS"
     misc_feature    9904..9917
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.8"
                     /tool="antismash"
     misc_feature    complement(9935..9947)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    complement(9953..9963)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(10001..11047)
                     /locus_tag="K6K39_RS02420"
                     /old_locus_tag="EASAB2608_00519"
     CDS             complement(10001..11047)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (77% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190930.1"
                     /locus_tag="K6K39_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00519"
                     /product="cytochrome P450"
                     /protein_id="WP_059247116.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 2.5e-189,
                     bitscore: 627.5, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 4.8e-12, bitscore: 44.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSSTARARATVFAPRLAALIGDHLGQDVFRLEPDTVGVAGHEV
                     ADRILAARRATETERPTFKPLHGRSITRSEASAVTRTIGNDVREALARPLPEDVDLAGP
                     WPLTGHLFLRDLILGQDPYRLRMLMSRNLELTPKLTWSVIAVGAALPGWPRPDARLTGL
                     ADRAARARGYQERRYAMGMYRRAAAPVCFTVSTLVANALWLGSPFDDGMSPRHIILESL
                     RLLPPSWNILRNASPEYPAIDGRIGERDDVLLLPLLSHRDPALWDDPDAFRPERWDGLD
                     PDTAPGYLPFGHSSERCWGRHMVMPLAELLLDLIRSSGLVVDPGQRVGKVPLLGLLGVE
                     EVRLIRSR"
     gene            complement(11165..11245)
                     /locus_tag="K6K39_RS41905"
     CDS             complement(11165..11245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038372.1"
                     /locus_tag="K6K39_RS41905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptorubin family RiPP precursor"
                     /protein_id="WP_223284023.1"
                     /sec_met_domain="atropopeptide_precursor (E-value: 1.0,
                     bitscore: 1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLFALRNRVAAAKSLKANAWYLWY"
     misc_feature    complement(11230..11244)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.04"
                     /tool="antismash"
     misc_feature    complement(11346..11360)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.02"
                     /tool="antismash"
     gene            11679..12227
                     /locus_tag="K6K39_RS02430"
                     /old_locus_tag="EASAB2608_00520"
     CDS             11679..12227
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012791.5"
                     /locus_tag="K6K39_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00520"
                     /product="universal stress protein"
                     /protein_id="WP_079080817.1"
                     /transl_table=11
                     /translation="MAPHEPSGDERTGKVVVGVSDSLAGLAALRRGIQEARATGRTLVA
                     VRAWEPPEGEALYLRQPEPSWARLWADDARQRLERAFDLAAGGPPADLRIVRRVVRGSA
                     GPVLCSIAASPDDLLVIGMARPRGPFARLHRRPVHRFVPARAECEVLVVAGPRLLPREA
                     RILRRSDLVAPPDRATAGR"
     misc_feature    11763..11765
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12351..12743)
                     /locus_tag="K6K39_RS02435"
                     /old_locus_tag="EASAB2608_00521"
     CDS             complement(12351..12743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010035792.1"
                     /locus_tag="K6K39_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00521"
                     /product="RidA family protein"
                     /protein_id="WP_059247114.1"
                     /transl_table=11
                     /translation="MTERRAILSGSTFEEQIGYARAVVDGDWVHVSGTTGFDYTAMTIS
                     DDVVEQAEQCLRNIGAALAEAGCGFADVVRVRYLLPDRADFEPCWPVLRRCFGEVRPAA
                     TMLECGLADPRMKIEIEVYARRPTGD"
     gene            complement(12800..13282)
                     /locus_tag="K6K39_RS02440"
                     /old_locus_tag="EASAB2608_00522"
     CDS             complement(12800..13282)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676838.1"
                     /locus_tag="K6K39_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00522"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_059247113.1"
                     /transl_table=11
                     /translation="MTSTVPAGANRPIFIDKQSPKAYRALVQTSEAVRAVAAEAGLDRV
                     LVELVNLRVSQLNGCAYCLHVHTRAALRAGDTPQRLGVLAAWRDTDLFTPAERAALALA
                     EATTAATDGAAQDAARAAAREVLTDDQTAAVIWVAVTINAFNRVSIMSRHPVRAEG"
     misc_feature    complement(13312..13328)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.05"
                     /tool="antismash"
     misc_feature    13314..13326
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            13458..13697
                     /locus_tag="K6K39_RS02445"
                     /old_locus_tag="EASAB2608_00523"
     CDS             13458..13697
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548858.1"
                     /locus_tag="K6K39_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00523"
                     /product="hypothetical protein"
                     /protein_id="WP_223283681.1"
                     /transl_table=11
                     /translation="MADIPDELVRLERSAEAERAKLAGLCGAEYDAQWQAWRRAAEAFQ
                     AAVTEQSAREGMSRYELEQAVKRAVRRTEEDPAR"
     misc_feature    13471..13486
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            complement(13783..14814)
                     /locus_tag="K6K39_RS02450"
                     /old_locus_tag="EASAB2608_00524"
     CDS             complement(13783..14814)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1125: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470864.1"
                     /locus_tag="K6K39_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00524"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_059247112.1"
                     /transl_table=11
                     /translation="MSVMIDIYETEFRKADLNLLVVFAALMREGSVTRAAAALHLSQGA
                     VSAALGRLRRLFGDELFTRTRTGVEPTPRAVQLARRIEPALALIQGAVTGRDRFDPATA
                     RHTFTLGMSDDLETALLPRLLAATAGLPGIRIAVRQANRNTVAELLDRGEIDLGIAAAP
                     AHGPDHRTEDLFSSGYTCLFSPRLLPLPTPLGLDDYLAHPHILISYDGRRGIVDDLLDA
                     RGLTRRVIASTTHFAGAALHLTTLPALATLPTHAAIVYAGTLGLTATEPPLPMPRYTVS
                     AIWHATVTDDPAHTWLRHLVSRTEPPVPPAQPGTGFGDPDRDHGPPRPPRADNSAAGQG
                     DWA"
     misc_feature    complement(14779..14790)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    14813..14827
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            14856..15815
                     /locus_tag="K6K39_RS02455"
                     /old_locus_tag="EASAB2608_00525"
     CDS             14856..15815
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388517.1"
                     /locus_tag="K6K39_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00525"
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_059247111.1"
                     /transl_table=11
                     /translation="MTSPGPAAPASPRTLTAAVVQAGAPLFDTRAALVRAEELVREAVS
                     ERGAEVVVLPEAFLGGYPKGLDFGITVGSRTPAGRDLFRRYHAAAVDVPGPEVDTLAAL
                     TRELGCHAVVGAVERRGGTLYCVALFFGPAGYLGLHRKLMPTAAERSLWGQGDGSTLPV
                     IDTGTARLGAGICWENYMPLFRTAMYAKGVDLWCAPTVDDRDSWQASMRHIALEGRCFV
                     LSANQYLRRDALPSDVHPVQGDSPDTVLIGGGSVIVSPLGEVLAGPLRDGEGILTAVLD
                     LDDLARARFDFDPTGHYARPDVFTLQVDRSARSTVSGI"
     gene            complement(15845..15976)
                     /locus_tag="K6K39_RS40750"
                     /old_locus_tag="EASAB2608_00526"
     CDS             complement(15845..15976)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS40750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_00526"
                     /product="hypothetical protein"
                     /protein_id="WP_260335011.1"
                     /transl_table=11
                     /translation="MADPRLPALALGGHPDRSEPLALADAGAARDTTATRARRARGP"
     gene            complement(16047..16427)
                     /locus_tag="K6K39_RS02460"
                     /old_locus_tag="EASAB2608_00527"
     CDS             complement(16047..16427)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669327.1"
                     /locus_tag="K6K39_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00527"
                     /product="hypothetical protein"
                     /protein_id="WP_059247110.1"
                     /transl_table=11
                     /translation="MHSITRGLTAGLLGAAALCLPAPAHAVAGTDADPPPAAHAAPPSG
                     AYCGPDKATGLAVWADRTESCATALEVASAYTKAATRTAEASATVRVGGTTWMCQERQG
                     DPNPYRECVATSDSGRRVVLSS"
     gene            complement(16607..17593)
                     /locus_tag="K6K39_RS02465"
                     /old_locus_tag="EASAB2608_00528"
     CDS             complement(16607..17593)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669271.1"
                     /locus_tag="K6K39_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00528"
                     /product="aldo/keto reductase"
                     /protein_id="WP_059247109.1"
                     /transl_table=11
                     /translation="MTDIPTRYLGELAVSAQGLGCMGMSHGYGATDDAQSIATLHRALD
                     LGVTFLDTSDFYGFGHNEELIGRAIAGRRDEVVLATKFGFANRLGEPTLIRGDAAYVRQ
                     ACDASLRRLGVDHIDLYYQHRVDPQVPIEETVGAMAELVRAGKVRHLGLSEAGAQTIRR
                     AHAVHPISALQSEWSLWTRDLEAEIVPVCRELGIGVVPFSPLGRGFLTGRYSSLDGMAE
                     TDVRRGQPRFADGNLERNLAIVAQLEELAAAKSVTAGQLALAWVQHRGEDVVPIPGTRR
                     QRYLEENLGALAVELTAEDLAAIEAAAPPEQIAGSRYDATSLTFVNR"
     gene            17818..18309
                     /locus_tag="K6K39_RS02470"
                     /old_locus_tag="EASAB2608_00529"
     CDS             17818..18309
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K6K39_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EASAB2608_00529"
                     /product="hypothetical protein"
                     /protein_id="WP_059247108.1"
                     /transl_table=11
                     /translation="MADPDDEPRDARKTRPRPARWRRRAVLLGLAGTLLGGTVWHLVSR
                     HEAKPRSAVVSSRSAVVGTWEAEGGATGRVEFAADGRFSAIGLPVRTSPDGGLTGRGRW
                     ALDGRGGSVALRPDRAPSAPVRDARLAVVRADGRVRLCVTSGSPGVLCDVLLRPAAARR
                     "
     gene            complement(18411..19895)
                     /locus_tag="K6K39_RS02475"
                     /old_locus_tag="EASAB2608_00530"
     CDS             complement(18411..19895)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547156.1"
                     /locus_tag="K6K39_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00530"
                     /product="MFS transporter"
                     /protein_id="WP_221333926.1"
                     /transl_table=11
                     /translation="MSASVSLGSHRGAPGGVPRHLGWTLALLALAQLLYALDLNIVFVA
                     LPEIGRDLGFPGQTQQLVVSAYVVFAGGFLLFGGRAADLLGRRRMFVLALVLYAVSSLA
                     GGLAPSREVIIAARAVQGIAGALLLPSTLSLINTLFEEGPERNRALAVWGGAGASGLTI
                     GALLGGVLTEHFGWPSVFYVNVPLGGLIALCALFVVPRDPARTARRTFDLPGSLSVTGG
                     ATLLVFALVEGPERGWGDSLVLGAFLLAVVLLVLFAVIEKRSADPLMPFRLFRNRSLTV
                     GMLVTFLYMATFGVLPYFLTVLMQSVHGYSALQTGLGFLIPSLAIAAGTQLGERFAGRR
                     GTRATLVIGFGIGVIGTVALAFGFDADAGYGLLVPGLVVSGVGQGIVWTAMWIAASTGT
                     APQEQGVANGVASTALNIGNAIGLAVFTVVADIGTEGRAGEALKTATADGEFLVVLLTA
                     AGMLVGLLVTLLLKHRPASAAAAASAPADEEPLAAR"
     misc_feature    complement(19864..19882)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(19875..19877)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20076..20447
                     /locus_tag="K6K39_RS02480"
                     /old_locus_tag="EASAB2608_00531"
     CDS             20076..20447
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641035.1"
                     /locus_tag="K6K39_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EASAB2608_00531"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_059247107.1"
                     /transl_table=11
                     /translation="MSRHPERDQIRIESVLSALGSPVRLAAVRVLDAGGEHNCTSVLEL
                     LGITAKSTMTHHWRVLRESGVIWQHPSGRENLLSLRRDDLDARYPGLLDAVLAGAAEDA
                     ALENASASAPAGPRGRSRT"
ORIGIN
        1 cgggcagggc cggcagccgg gccagccgcc ggtgcccgac ggagctgtcc gcggcgagcc
       61 gggcacggtc gcggtcgtgc gtggtccgta cggcgaggac ggtgccgtcg ggcgtgatgt
      121 accggccggg gccggtctgc cgtgcggagt cgcccgggat gcagctgagg gacgtggtct
      181 cgtacttccg cagggctccc ccgccgaggg cgagcagggt gccgtagccg tcggtgcgcc
      241 acactccgtc ggtgaccggc gggccggggc gcgccgcgga cgcggcgggt acggcggtgg
      301 cggcgagggc gagggcggcc acggtggccg tgaggatgcg cacgacgggg tcctcctggg
      361 acggtcggtt ccgcggacca ccaccgtgtc ggacggccgt actcccccac caccctgcgg
      421 cccggtgcac cggcccgggg gacaactccc ggacacccca cccgccgctg ggggcctggg
      481 gcctgtcgtt cggatcatgc cgaccaacgt gccgcacagc cgccctgatc cgaacgacag
      541 gccctagccg tgcactccgg ccggccgctc caggctcgtc tcggggaacg ccgacgcctc
      601 cggcagatgg gccttggccc actccgccag ttcgcgcagg gcgggctcca gggccgcgcc
      661 ggcctcggtc agccggtagg acacgcgcag cgggggacct tcgtcgacct cgcgcaggac
      721 gaggccggcc gcaccgagtt cggcgagccg gtcggacagc atgcgttcgc tgatgccggg
      781 gatggcccgc cggaggtcgg cgaagtaggc gggctgctcc accagcacgg ccacgatcgg
      841 gccgctccag cgcttgccga gcagctggaa cacacgggtg atgccctggt ccacccgctt
      901 gcacgccgcg ctgtcgtggt tctgctccgc cgccatgccc ccagggtact accccagcgt
      961 agggggctga gaaaaagtaa gtccgtgtga taaacatagt ccagtacgaa acgtgagccg
     1021 acgccctggc gtgcggctgc ccagcccttt ctggagacac ctcatggcca ccctgctgca
     1081 catcgattcg tccgtgttcc ccaccgaggc gtcggcttcc cgcgccgtga cggaggcgtt
     1141 ccgcaagcac tgggaggagc agcacccgca gggcacggtc atctaccgcg acctggcggt
     1201 cgacccggtt ccgcacatca ccgccgacgc gcacctcgcc ggtttcgtcc ccccgaccgc
     1261 gcacacgccc gagcaggccg ccgtgttcgc cgagcgggtc aagctgatcg aggagctgga
     1321 gcaggccgac gcgatcctga tcggcgctcc gatgtacaac tacacgatcc cgtcaaccct
     1381 caaggcctgg ctggacaaca tcatcctcat gggccgcacc gcgggtgaga acccgtcggc
     1441 caagggcacc ccggtcaccg tcgtcgccag ccggggcggc tcctacgcgc cgggcacccc
     1501 gcgcgagggc tatgagtacg tgcagaccta cctcaaggcc gtcctggccg acgccctcgg
     1561 cctggacctg gagttcatcg tgccggagct gacgatggcg tcgaagaacc cggcgatgtc
     1621 cgagctggtc ccgctgtacg aggcctcccg cgaccgcgcc ttcgaggccg ccgaggcccg
     1681 ggcccggcag ctggcggagc gcctcgcggc ctgagacgcc gcacctaccg caccacggac
     1741 cccgggccgg cgcacagcgg cccggggccg cacccgtgcc cgcgacatgc cggccaccgg
     1801 gcgcgggcta atctgcgggc gcggacgtac ggggcgcacg gcgacggctg agcccgggat
     1861 gccggagcct gccctcccgt ccgattcgcg cgtccggaag cagagggacc ggccacagca
     1921 cacgtccggg gagagaccgt atgagcacag cgcacaccac gagtcccgcg cgtaccttgc
     1981 gcgccgccta cgaggccgcc tcggccgtcg tcgccgggct gggcgacgag gagtcctggc
     2041 tgccgaccgg ctgcacgggc tgggcggtcc gcgacctggt cttccactgt ctgcacgacg
     2101 cccagcgcgg actggtggcg ctgcacacgc cggcggacgc gcccgtcgac cgggacgcgg
     2161 tgacgtactg gcaggactgg cgtccggaca ccgccggggc ggcgaacggc cggcgctggg
     2221 cgcgggtgaa cgggagcatg ttcctggtct tcgggcagtt gcaggagctg tatctggaga
     2281 cgttggcggc ggccgtgcac gcggcggact cggtcgatcc ggcccggcgg gtggccaccc
     2341 aggggcatgt gctgacggcc ggcgacctga tcaccacgct cgcggtggag gcgaccgtcc
     2401 accacctcga cctgaccgtc cggctcccgc tcgcaccggg cccctcaccc gagggcctgg
     2461 cggcggtgcg ggccacgctg gacggcctgc tcggcgggcc cgctccggcg gagtggagcg
     2521 acgaacggta cgcgcgcgtg ggcaccggac gggccgcgct caccgacacg gaacgcgccg
     2581 ccctgggcgc ggcggcggac cggctcccgc tgttcggctg aggccggctc ccaccgtgtg
     2641 cggccgagga ccggctcccg tcggcgtcga gggccggccg gcccccggcg gcacgcccaa
     2701 cgcggcgaca gccgggtccg acacctgcgc ggtgcggggc atcccggtcg ggttgatgac
     2761 accctgcgcc ccatgaacac ccctcccagc atcaacagtt acgtcgaccg ggtcacggcc
     2821 ggtcccggcg gggcgatgac cgacgaagtc ggcgtcatca ccggcgatct caccgtggcg
     2881 accatcctcc tgtccgacgg ccgcagtgtg cgggtcgccg tccagcattc cggcagcgac
     2941 acctggtaca ccctcgccgg gagccccgcc cccgtgccgg ccggccaact cgcggcctac
     3001 caccgggacc tgctgggccg gatccgccgg ggcggcggaa cccgcgccac ctgagcccgc
     3061 tcgggcgcac ggccaccggg ccgcccgccc gagcgggagg ggcggtgtcc gtgcgcctcc
     3121 cggcccctcc cccggccgcc gccgcccgca ctcggtggga ccggcgcggg gaccgatggg
     3181 ggcgcgccgg gtttcggcgc cccgctccgg gggagtcggt gcgcgtggtc tcgtatggac
     3241 cccagcagcg tgtgtacgtc ccggagctgc gggccgactg gctgacccag agcttcgtgc
     3301 actgggccta ctcgcccgcg cagatccagc tcctgctgcc gcgggggctc gccgtggaca
     3361 cgtacgacgg ttcggcgtgg gtgagcctca cgccgttcgt catggccggg gtgcgcccgc
     3421 cggggtcgcc cgcggccctg ccccctttcg ccgagacgaa tctgcgcacc tacgtgcggg
     3481 gcccggacgg ccgggacggg ctgtggttcc tgtccatcga ggtggcctgc ccggtgatgc
     3541 tcgccgcccg cgcgatgggc gtgccgtacc gcctgggccg cctggcgctg gcccggcacg
     3601 gggacacggt ggcctacacc ggggtccggt ggggcggtgg gccccgctac cgtctggtgg
     3661 tccggccggg cgagccggtc cggccgagcc gtctggacgt ctggctgacc tcgcgctggc
     3721 gggccttcac cctgcggtgg ggcgtgctct gggagacccc cgtcgagcac gcgccctggc
     3781 cgctgcgcga gacgcgcctg gaggcgatgg aggagaccct cacccgggcg gcgggactgc
     3841 ccccgcccgt ggcgcggccg atcgtgcact tctcggacgg ggtgcggaac gtgcggctgg
     3901 gcgtgtcgcg tcccgtgcgg cgccgcggcc gggtccgcga ccgggccgcc ccgggcggat
     3961 gaacgcgccc gcgcccggcc ccgcccggct gcgcttcgac ggctggatcg ccggtatcgg
     4021 gacggcgtcc gggacccgcg tggtgctcgg gcactggccc tgctcgccct tcggcccgtt
     4081 cagcgacgtg atgctcgaac gggaggacgg tcaccgcctg ctgctggccc cgacccggcg
     4141 cacggcggag ttcatcgccg gcacctacgc cttcgacgag gtgcggatcg tgccggtacg
     4201 ggtccacgtc accggggacc ggtggaccgt caccgccggt tcgctgctcg acctgcgcct
     4261 gaccgtcggc cgccggagtc tgccggggct ggcgctgcgg gccgtccccg gcgcgctggc
     4321 cgcgcgtccc ggctggacga gggtgaccga cccgccggcc cgtgtgctgc tcggggtacg
     4381 gacccggggc agcgccggcg gcgggcggcg cgagtggtac ggcgcgcgcg atctgcaccg
     4441 gatcaccgcg gcgagcgccg tccacgaagg gcgggacctc ggcccgctcg ccccggtcga
     4501 gcccgccgtc cgcttcggat tcggctcggc gccccgtacg ccgagcctgg tacgcgtcac
     4561 gacgacggtg ggcgcgccgc gcgccgccgg acgccgtgga cgcccccgtc gcacgccacg
     4621 gcagccagga aggaggcctg tcatgaacgg accggcacag cccggaacgc ccgggcccga
     4681 gtccaccggc ggcaccgaca tgaagctgct cggtgtctat ctcaacgacc acctcgccgg
     4741 cgccaccgcg ggcgcccagc ggatcggcca tctggcccgc accatgcgcg gttccgcgct
     4801 cggccgggcc ctcggccccg tcgccgccga gatcgacgag gaccgggcga ccttgctggc
     4861 catcatgcgg aacctgggag tccccgtgcg ccactacaag gtctgggcgg gctgggccgc
     4921 cgagaaggcg gcccggctca agggcaacgg ccggctggtg cggcgctctc cgctcagcac
     4981 cttgctcgaa ctggaggcgc tgcggctcgg ggtggagggc aaggcggccg tctggtccac
     5041 cctgcgccgg ctcgcgtcca ccgacgagcg gctggacgcc gcactgctcg acacactcct
     5101 cgaccgggcc gcacgccagc aggacacggt ggaggagtgg cgcgggcgcg cggccgaggc
     5161 ggccctgcgg ccgaccgccc gggccgccgc gtgaccccgg gccggggcac cggcccggcc
     5221 cggacgcgag ggcgcggtgc cggagtgcgt gtcgtgtcct gagcggcgtg tcggtgtctt
     5281 gcgcaggctg accgggcccg atcctggggt ctgccggcag gcgggagacg gtcgtgatcg
     5341 aactggccgc ggcgttcgcc gtcgcgggag cggcgagcag cgccgtgggc accgcgtgcc
     5401 agcgcaaggc ggcctcggcc agcagccgcg gcggggtccg gctgctcgcg gagctggtgc
     5461 gccggccggt ctggatgatc ggcatggccg gcgtgatctg cgccgcggtg ttccagagcc
     5521 tggccctggt caacggcccg ctcgcgctgg tccagccgct gttcgtcctg gagctgccgt
     5581 tcgcgctgct ggtcgccgcg ccgctgatgc accggcggct gccccgctcg ggctggtggg
     5641 gtgtgggcgg ctgtgtgggg ggcctcgccg tgctcctcgt cgcggcggcc ccgcacggcg
     5701 cgacccatca cgcgcccctc gaccggtgga tcccggccgt gtgcctgtgc gtcggcgtga
     5761 tggccgcggc cgttctcctg gcgggccggg gtcacccgcc ggcccggcgc gccgcgttcc
     5821 tggccgccgc ctcggctacg ggcaacgcgc tgaccgcggc cctgctgaag tcggccgccg
     5881 gcacgttcgc cgaccagggt ttcacggcgt tcctgcggtc ctggcagacg tacggcttcg
     5941 cgctggccgg cgtctgtgcc gtgctgctgc tggagaacgc gttgcaggcc ggtccgctgg
     6001 ccgcggcgca gccggcgctg accatcggcg acgcggtggt gagcctggcc ctcgcggtca
     6061 cgctgttcga cgagcggatc cgcaccggct ggtggctcgt gccggaggcc tgcggtgccc
     6121 tgctgatcgt cctgggcgtg ctggtcctca gccgggccgt gcagcggatc gtcgtaccgc
     6181 cccttccggc cgaggagcgg aacccggcgg cgtgaggccc ctcagggagc ggcgacgagc
     6241 ggcggctctc cccagtcgga ggtcagcgcg tcccgcaggg cgcgggccgg ggccggcccg
     6301 atgcgctccg tcagcaccga ctcgatcacc ttgatggtgg cctgcgcccg ctcgtgcacc
     6361 cgctgcccct cggcggtcgt acggatcagg cggcggcgtg cggacccggg gtcgggcacc
     6421 tgctccagca gccccatgcc gatcagcccg tgcaccgcct gatggaccgt ctgccgggtg
     6481 acgccgatcc gccgggccag ttcggagacg gtggtgccct cggtgtcgag cagggcgaag
     6541 acggacgcct gcgccgtcgt cacgggctgc tcccccgccg cctccatgct ggcgaacaga
     6601 gcgtcctcga accagcggcg ggcctcggac agcagctggg gcaggttggc ggcgcggtga
     6661 ctcatggctc ctcggaagat cgggtacccg ccgattatcc tccggcgcag tgacgggcga
     6721 cgaaggcggc cgtcctgtcg aagcagcgct cgacctcctc ctcggcgagc cccgcccaca
     6781 ggtggttcgc gccggccacc cgcacgtggt cgaccggaac ccgcgcggca cgcagggccg
     6841 ccgtgagccg ttcgctctgt gcgcagggca ccagctcgtc cccggtgccg tgcagcacca
     6901 ggaagggcgg tgcctgcggg gtcacccgca gggcggggct ggcgtcgcgg gccgggccgg
     6961 gggctgcggc gggggccgcg ccgagcagca gcgcctcgaa ggtggccggg tcgtacgggt
     7021 cgaagcggcc cggcgcgtgg tcgtcggcga ggcgggtgag gtcggtgggc gcgtaccagg
     7081 tgacacagcc gcgtacggtc gccgccccgc cggggccctg gggcgtggtg agcgcggtga
     7141 gcgcggccag gtggccgccg gcggactcgc cccagaggac cacccgctcc ggatcgaggc
     7201 cgagatcacc ggcccggtcg cgcagccagg tcagcagcgc gcgcaggtcg tcgagctggg
     7261 ccgggtgccg ggcttcgccg ctgagccggt agtcggggca gaccacggcc gggccggagc
     7321 gcgccagccg ggcgaagggt cccggccgcc agtgccggaa gcgtggcccc aggtcgtccc
     7381 ggagtccggt gcgccagccg ccgccgtgca cgaagacgac gaccggcacc ggtccccggg
     7441 ccggctcggg cagccacagg tcggcctcca ggggccggct gccgtcgggc acggcgtaga
     7501 cggcgccgcg cagcagccgc acgcccgggg cgggacgggc gggcgccggc aggggcaggc
     7561 gcaccgggtc cggcggggcg aggaattccc gggggaagtc cgggccgcgg tggcggtcgg
     7621 gtacggcgcg ttcggtcatg ggtccttcag cgggcgaggc gggggaacag ggtccgggcg
     7681 ttggcggtgg tcagcgagcg ccagctggtg cccggagccg gggcgggcgc ggtgtcgaag
     7741 gacgcggcgt gcgcctcggc cgcctcggcc ggtgtccagc agtagtcgct gccgtacagc
     7801 agccggtccg ggtcggccag gccgagcagg gcgggcacct gtcgggggaa ggccgggccc
     7861 gccgtgtcgt agtagagccg gcggagctgt gcgacggcgt ccggtgcctc ggcctcgccg
     7921 ggcgggaaca gccgcatgaa cccgttgatc cggtcggcga ggacgggcag cgccccgccg
     7981 cagtggggca cgatcacctt caggtccgga tggcgttcga gcgtcccggc gaacagcagg
     8041 tccgtgacgg agcgggcggt gtcgaagacg aactccacca tggggcgcgg ccggccgagc
     8101 gcggactgct cccagcacac cggtgacgtg gggtggacga agaccacggc ccggcgccgg
     8161 ttcagttcgg cgaagacggg ttccaggcgc gggtcgccga ggtagacgcc gtggctgtgg
     8221 gtctccagca cgacgccgtc ggcgtggagc tggtcgaagg cgtacgcgat ctcggcgagg
     8281 gcgccgtcga cgtcggggag cggcagcgag gcgaacaggc cgaaccgtcc ggggtggtcg
     8341 cgtacgatcc cggcgccgtc ctcgttgacc tcgcgggcca gcgcccgggc ggcggccggg
     8401 gcgccgaagg acacgcccgg ggacgacacc gacagcacgg cggtgtcgat gccgctgcgg
     8461 tccatcagct ccaggtgggc ccgggcggac caggccggcc aggcgggcat cccgtcgggc
     8521 cgctcgtgcc cggccgccct ggcctggcgg acgtaggact cggtgacgaa gtgggcgtgg
     8581 acgtcgacga ggccgggacg gtcggcgggt gtggtcatcg tgggtcctcg tgggtgggtc
     8641 ggggggcggg gcggggggtg gtgggggggc gtgggggggg gggggggggg gggggggggg
     8701 gggggggggg gggggggggg ggggggctgg aagccgggcg tcaccgacgg gggtgatcat
     8761 cggcaggggt gaccatcggc gggtgctcac cagcggggtg cggggcgcct ggtccggcgg
     8821 acgcggaacc tggtccggcg ccgccgtcgc gcccgcccgt gccgccgtcg cgcctgccgg
     8881 tgccgggcgc gggtgtcggc ccgggcgcgg gcgccgctcc gacaacaggc gccggtccgg
     8941 gcgcgggcgc cgctccgacc acggacgccg gtccgaccac ggacgccgat ccggctgccc
     9001 ggccgcgccg ccgcagcgcc gacaccgcgc gttcgccgat cacgatgccc agcaggccgg
     9061 tcaggcccag caggggcggg gcgggtgagc gcaggccgag ggaccagtag acggcgccca
     9121 tgagcgcgcc tgcggcgaag gcgggagcgg cggcgcgcag gaaagcggcg acggcggccc
     9181 gccgcgcccc ggtcggcggt ctcaccacgt ctccggcagc gtctgcccga gcagcatgcc
     9241 gagcaggccg aacagggcga cgggcggtgg cgccggcgac ccgacccgca gcagcgcgta
     9301 cagggcgcct accaggacgc ccgccgacag cgcctcgacg tacggcacag cggtcagctc
     9361 ccggtgcgcc actggtggtc ggggaggaag cggacgtcgt actgtccggg cacggtcgcg
     9421 aacttctccg gggcggggac gaagggccgg gccggcaggc ccagttcgtc ggccggtgtg
     9481 ccgagggtct cgaagaaccg ctcgaaggtg ccgcccggcc cggcggcgac gccgacgacc
     9541 tgtgagtggt ggcgttccat gcggtaggcg tgggtgcagt tcttcgggac gaagccgaag
     9601 tccccggggg tgagcagctt ctcgtgctgc tcgccctcca ggtcctccac gaagagccgt
     9661 acggcgccct gggtgatgta gaagacctcg taggtgtccg cgtgggagtg ggcggggatc
     9721 agctccccct tggggccttc gcaggtgaag aagttgaagg tgttctcggt ctgttcgccg
     9781 cccgcgtaga tcgtgacgag gtcaccgaac aggtgcgcgc ggtcgcccag ccccttctcg
     9841 atgaagtagg gcttgcccgg ctccggcggg atgaaggagc gggcgcggtg gcgggtggcg
     9901 tactcgatgg tcatgcagag cctccggttc cgacgtggca atgtcaggct acctgacatt
     9961 gcagccgcac ccaacggtgc cccgccggtc cgctgccccg ctagcgtgac cggatcagcc
    10021 gtacctcctc cacgcccagc aggcccagca gcggaacctt gccgacccgc tgaccggggt
    10081 cgaccaccag cccggagctg cggatcaggt ccagcagcag ctcggccagc ggcatgacca
    10141 tgtgccggcc ccagcagcgt tccgacgagt gcccgaaggg caggtagccc ggggcggtgt
    10201 ccgggtcgag gccgtcccag cgctccggac ggaaggcgtc cggatcgtcc cagagagcgg
    10261 ggtcccggtg ggagagcagc ggcagcagca ggacgtcgtc gcgctcgccg atccggccgt
    10321 cgatcgccgg gtactcgggc gaggcgttgc gcaggatgtt ccaggacggc ggcagcagcc
    10381 gcagcgactc caggatgatg tggcgagggg acatgccgtc gtcgaacggg gagccgagcc
    10441 agagggcgtt ggccaccagg gtggagacgg tgaagcacac gggcgcagcg gccctgcggt
    10501 acatccccat ggcgtaccgc cgctcctggt acccccgcgc ccgcgccgcg cggtcggcga
    10561 ggccggtgag ccgggcgtcc gggcggggcc agccgggcag ggcggcaccg accgcgatca
    10621 ccgaccaggt gagcttgggg gtgagttcga ggttgcggct catcagcatc cgcagccggt
    10681 aggggtcctg gccgagtatc agatcgcgca ggaagaggtg cccggtcagc ggccagggac
    10741 cggccagatc cacgtcctcg ggcagcggcc gggccagggc ctcgcgcacg tcgttgccga
    10801 tggtgcgggt gaccgcggac gcctcgctgc gggtgatgga ccgtccgtgc agcggtttga
    10861 aggtggggcg ttcggtctcg gtcgcccggc gcgcggccag gatgcggtcg gcgacctcgt
    10921 gtcccgcgac cccgacggtg tcgggttcga gccggaagac gtcctggccc aggtggtcgc
    10981 cgatgagcgc ggcgagccgc ggggcgaaca cggtggcgcg cgcacgcgcg gtggatgacg
    11041 gcggcatggc tcctccggta cgggggcggt gaaggccgcg gcacgacggg acaccgccgc
    11101 ccggccggac cgcgtcgcgg tgcggccgga caacgatgtc accgctacag cggcgggtgc
    11161 gggatcagta ccagaggtac caggcgttgg ccttgaggct cttggcggcg gcaacgcggt
    11221 tgcggagggc gaaaaggagc ttcatcactg cacctcccct cgggggacgg acggatgaca
    11281 cgcgccgcac cggagggggc cggtgaagat cacgtgtcgg cgacgccccg gaaccttccc
    11341 gtgatcgttg actgattaat caccagggag ttcaaaatcg cggccaggtg gtcggtttca
    11401 gactttcgcc gatcatcggt gctccggttt gacgtaccac ccggcacgcg ggagccgtac
    11461 cgccgccgga ggctccctcc gctgctggcg gacgccgccg accgcccgga tgccggacgg
    11521 cccgtcaccg agagcggacg cgcgccgcgt ccccgtcggc cggcccctcg gccccacatt
    11581 ggcgagatct ggaccccgca tgcatctgct ccgatcaagg ccacttttcc ccgattggac
    11641 tttgcccgag cgagattggc cttcctaacg tgggcggcat ggcaccacac gaaccctcag
    11701 gtgacgagcg aacggggaag gtcgtcgtcg gggtgagcga ctcactcgca ggactcgccg
    11761 cgttacgccg cggcattcag gaggcccgcg ccaccggccg gacgctggtg gcggtccggg
    11821 cctgggaacc tccggagggc gaggccctct atctgcgcca gccggagccg tcctgggccc
    11881 gcctgtgggc cgacgacgcg cgacagcggc tggagcgggc cttcgacctg gcggcgggcg
    11941 ggcctccggc ggacctgagg atcgtacgac gcgtggtcag ggggtcggcg gggccggtgc
    12001 tgtgctcgat cgccgcgtcc ccggacgacc tgctggtcat cggcatggcc cggccgcggg
    12061 gcccgttcgc ccggctgcac cgcaggccgg tgcaccggtt cgtgccggcc cgggccgagt
    12121 gcgaggtcct ggtcgtggcc ggcccccggc tgctgccgcg cgaggcccgg atcctccggc
    12181 gcagcgacct ggtggcaccg cccgaccggg cgacggcggg gcggtgaccg gcgggggccc
    12241 gtccgtcgga cccggcggcc ggcgaggcgg gcgcgggccg gtgaccgggg tccgtggcgg
    12301 cctgttccgt gctacggcgg cgggccgccc gcactccccc tgagccctgc tcagtccccg
    12361 gtcgggcggc gggcgtagac ctcgatctcg atcttcatcc gggggtcggc gaggccgcac
    12421 tccagcatgg tggcggccgg ccggacctcg ccgaaacagc ggcgcagcac cggccagcag
    12481 ggctcgaagt ccgcgcggtc cggcagcaga tagcgcaccc gcaccacgtc ggcgaagccg
    12541 caccccgcct cggccagcgc ggccccgatg tttcgcaggc actgttcggc ctgctccacc
    12601 acgtcgtcgg agatggtcat ggcggtgtag tcgaagccgg tggtcccgga gacatgcacc
    12661 cagtccccgt cgaccacggc acgggcgtaa ccgatctgct cctcgaaggt ggagccgctg
    12721 agtatcgcgc gtcgttccgt catgcgcgga acgctaggtg accagcaccg atccgtccat
    12781 cgatcaccgc gtcgccgcct cagccctccg cccgcacggg gtgccggctc atgatcgaga
    12841 cccggttgaa cgcgttgatg gtgacggcga cccagatcac ggccgccgtc tgatcgtcgg
    12901 tcaggacctc gcgcgccgcc gcacgggcgg cgtcctgggc ggcgccgtcg gtcgcggcgg
    12961 tggtcgcctc ggcgagggcg agggcggcgc gttcggcggg cgtgaacagg tcggtgtcgc
    13021 gccaggcggc gaggacaccg aggcgctgcg gggtgtcccc cgcccgcagc gcggcccggg
    13081 tgtgcacatg caggcagtag gcgcagccgt tgagctggga cacgcggagg ttgaccagtt
    13141 ccacgaggac gcggtccagc ccggcctcgg cggcgaccgc gcggaccgcc tcggacgtct
    13201 gcaccagggc gcggtacgcc ttcgggctct gcttgtcgat gaagatcggc cggttggcac
    13261 cggccgggac ggtactggtc aacctggact cctccgggtg ccgcttgttg aatgtgaaac
    13321 tatcacggct gggcgcgggt cgagtgcggg gcttcgcacc ggcggcaggg cgcccgcgcg
    13381 gcggcgggat cgtcatgccg ggccgcccgc ggcgctcccg ctcagcggtt cgacgggagc
    13441 gcgcatagca tccaggtatg gcagacattc cggacgaatt ggtcaggctg gagcgttccg
    13501 ccgaagcgga gcgggccaag ctggccggcc tgtgcggtgc cgagtacgac gcccagtggc
    13561 aggcgtggcg acgggcggcc gaggcgttcc aggccgcggt gacggagcag tcggcacgcg
    13621 agggcatgtc gcggtacgag ctggagcagg ccgtgaagag ggcggtccgg cgcacggagg
    13681 aggatccggc gcggtagccc gacacgaccg gcgcgcgcgg ggcggcgcgg tggtctccgg
    13741 gcgcgcctcg acgccgtacc gaccgccgca ctcgtcgcat cgtcaagccc aatccccttg
    13801 ccctgcggcc gagttgtctg cgcgcggcgg ccgcggcggt ccgtggtccc ggtccggatc
    13861 gccgaatccg gtgccgggct gcgcgggcgg gacggggggc tcggtgcggc tgacgaggtg
    13921 gcggagccag gtgtgggccg ggtcgtcggt cacggtggcg tgccagatcg cgctgacggt
    13981 gtagcggggc atgggcagcg gcggctccgt ggcggtcagg cccagggtgc cggcgtagac
    14041 gatggccgcg tgggtgggga gggtggccag ggcgggcagg gtcgtcaggt ggagggcggc
    14101 gccggcgaag tgggtggtgg aggcgatcac ccggcgggtc agaccgcgcg cgtccagcag
    14161 gtcgtccacg atgccgcggc ggccgtcgta ggagatcagg atgtgcgggt gggccaggta
    14221 gtcgtccagg cccagggggg tcggcagcgg cagcaggcgg ggagagaaca ggcaggtgta
    14281 gccggaggag aacaggtctt cggtgcggtg gtcggggccg tgcgcgggcg cggcggcgat
    14341 gccgaggtcg atctcgccgc ggtcgagcag ctcggcgacg gtgttgcggt tggcctgccg
    14401 gacggcgatc cggatgccgg gcagcccggc cgtggcggcc agcagccggg gcagcagcgc
    14461 ggtctccaag tcgtcggaca tgcccagggt gaacgtgtgc cgggcggtgg ccgggtcgaa
    14521 gcggtcccgg ccggtgacgg caccctggat cagcgcgagg gccggctcga tgcggcgggc
    14581 cagttgcacc gcgcgcggtg tgggctcgac gccggtgcgg gtccgggtga acagctcgtc
    14641 gccgaagagc ctgcgcaggc ggcccagagc ggcgctcacc gcgccctggc tcaggtgcag
    14701 cgcggcggcg gcgcgggtga cgctgccctc acgcatcagg gcggcgaaga ccaccagcag
    14761 gttgaggtcc gccttcctga attcggtttc gtagatgtcg atcatcacgg acatcagctt
    14821 gctcgatgac cggcgggatt cctagcctcg gtgccatgac ctcccccggc cctgccgccc
    14881 ccgcgtcccc ccgtaccttg accgccgccg tcgtccaggc gggcgccccg ctgttcgaca
    14941 cgcgggccgc gctggtccgc gccgaggaac tcgtccgaga ggccgtctcg gagcggggcg
    15001 ccgaggtggt cgtccttccg gaggcgttcc tcggcggcta ccccaagggc ctggacttcg
    15061 gcatcacggt cggcagccgg accccggccg gccgcgatct cttccgtcgc taccacgccg
    15121 ccgccgtcga cgtccccggc cccgaggtcg acaccctggc cgctctcacg cgggaactgg
    15181 gctgtcacgc cgtcgtcggc gcggtcgaac ggcgcggcgg caccctctac tgcgtcgccc
    15241 tcttcttcgg ccccgccggc tacctgggcc tgcaccgcaa gctcatgccg accgccgccg
    15301 aacgctcact gtggggccag ggcgacggct ccacgctccc cgtcatcgac accgggaccg
    15361 cccgtctcgg tgcggggatc tgttgggaga actacatgcc gctgttccgt acggcgatgt
    15421 acgccaaggg cgtcgacctg tggtgcgccc cgacggtgga cgaccgcgac tcctggcagg
    15481 ccagcatgcg gcacatcgcc ctggaaggcc gctgcttcgt cctcagcgcc aaccagtacc
    15541 tgcgccgcga cgccctgccc tccgacgtcc accccgtcca aggtgactcg cccgacaccg
    15601 tcctgatcgg cggcggctcg gtcatcgtct ccccgctcgg cgaggtgctc gccggtccgc
    15661 tgcgcgacgg cgagggcatc ctgaccgccg tactcgacct ggacgacctc gcccgcgccc
    15721 gcttcgattt cgatcccacc ggccactacg cgcgccccga cgtcttcacc ctccaggtcg
    15781 acaggtcggc ccggagcacc gtcagcggca tctgaccggc acccgcgcgg gctgcggagg
    15841 cgggtcaggg gccgcgggcg cgccgggccc gggtggccgt cgtgtcgcgt gcggccccgg
    15901 cgtccgcgag ggccagtggc tcggagcggt ccgggtgccc tccgagcgcg agcgccggca
    15961 ggcgcgggtc agccatgacc ggcctccgtt agggagaagt ctccgggtca ggacgacagg
    16021 tcaggacgac gggtcaggac gacgggtcag gacgagagga cgacccggcg tccgctgtcg
    16081 ctcgtggcga cgcattcccg gtaggggttc gggtcgccct ggcgctcctg gcacatccac
    16141 gtggtgccgc cgacgcggac cgtggcggac gcctccgccg ttctggtcgc ggccttggtg
    16201 taggcgctcg ccacctccag ggcggtggcg caggactcgg tccggtcggc ccagaccgcc
    16261 agcccggtgg ccttgtccgg tccgcagtac gcgcccgacg gcggggcggc gtgcgcggcc
    16321 ggcggcgggt cggcgtcggt accggcgacc gcgtgggccg gagccggaag gcatagtgcg
    16381 gcggccccca gcaggccggc ggtcaggcct cgcgtgatcg agtgcatcgc gtgtgcctcc
    16441 ttcgtggcgg cgacgggggt ggtctgcgcc ttcgcttccc ccgatgggga tgaaacccgg
    16501 gtatgccgtg catacccggc ctttctccgt acgcggatca tcccaccccc gcaccccggc
    16561 cgcgcgcggt ccgcccccgg tcgggagcgg agcacccgga cggacgtcag cggttgacga
    16621 aggtgaggct ggtcgcgtcg tagcggctgc cggcgatctg ctcgggcggc gcggcggcct
    16681 cgatcgcggc gaggtcctcg gcggtcagct cgacggccag tgcccccagg ttctcctcca
    16741 ggtaccgctg ccgccgggtg cccgggatcg gcaccacgtc ctcgccccgg tgctgcaccc
    16801 aggccagggc gagctggccg gcggtgacgg acttggcggc ggccagctcc tccagctgcg
    16861 cgacgatcgc caggttccgt tcgaggtttc cgtcggcgaa ccgcggctgg ccgcgccgca
    16921 cgtcggtctc cgccatcccg tcgagcgagg agtaacggcc ggtcaggaag ccgcggccga
    16981 gcggcgagaa cggcaccacg ccgatgccga gttcgcggca gaccggaacg atctccgcct
    17041 ccaggtcccg ggtccacaac gaccactcgc tctgcagcgc ggagatcggg tgcaccgcgt
    17101 gcgcccggcg gatggtctgc gcgccggcct cggacagccc gaggtgacgg accttgccgg
    17161 cccgcaccag ctcggccatg gcgccgacgg tctcctcgat gggcacctgc ggatcgaccc
    17221 ggtgctggta gtagaggtcg atgtggtcga cgccgagccg acgcagcgag gcgtcacagg
    17281 cctggcgcac gtaggcggcg tcgccgcgga tcagggtggg ctcgcccagc cggttggcga
    17341 agccgaactt cgtggccagc accacctcgt cgcgccgccc ggcgatggcc cgtccgatca
    17401 gctcctcgtt gtgtccgaag ccgtagaagt cggaggtgtc gaggaaggtc acgccgaggt
    17461 cgagggcgcg gtgcagcgtg gcgatcgact gcgcgtcgtc cgtggcaccg tagccgtggc
    17521 tcatgcccat gcagccaaga ccctgtgcgg agaccgccag ttcgcccaag taccgggtgg
    17581 ggatgtcggt catgtcgctg cctcctgggc tcgtcgatcc gtgtcccctg gacgctagat
    17641 cttggagcgc gctccaagtc aaacggcggc cgggcacgac ggcaggccga ccaccggaac
    17701 cgcacccgct ccgggagacc cttgcgcgcc acccggcccc cggccatgat cccctcgggg
    17761 ccgacgcgcc ggcttcccct ggagcctgcc cgtcccggtg tgaggagcac gagaagcatg
    17821 gccgacccgg acgacgagcc acgggacgct cggaaaaccc ggccacgacc ggcgcgctgg
    17881 cggcggcgcg cggtgctcct gggcctggcc gggacactcc tcggcgggac ggtctggcac
    17941 ctcgtctccc ggcacgaggc gaaaccccgg tcggccgtgg tctcctcccg gtccgcggtc
    18001 gtcgggacat gggaggcgga gggcggcgcc accgggcggg tggagttcgc cgccgacggg
    18061 cggttctcgg cgatcgggct gccggtccgc acgtcgccgg acggggggtt gaccggacgg
    18121 ggacggtggg cgctcgacgg ccgtggcggg tcggtggcgc tccggccgga tcgcgctccg
    18181 tccgccccgg tccgggacgc gaggctggcg gtcgtgcgtg ccgacggccg cgtgcggttg
    18241 tgtgtcacct cgggttcgcc gggggtgctg tgcgacgttc tgctgcgacc ggccgcggcc
    18301 cggcggtgac ggcaccgcag ggctcgctgc gggggcgccc ctgagcgagc cgtgcggtcg
    18361 ggcgggtccg tccgctgccg ctgacgggtc cgcggcatgg gggtcgggga tcagcgggcc
    18421 gccagcggtt cttcgtcggc gggcgcggag gcggctgcgg cggcggatgc cggccggtgc
    18481 ttcagcagga gcgtgacgag cagaccgacg agcatgcccg ccgcggtgag cagcaccacc
    18541 aggaactcgc cgtccgccgt cgcggtcttg agcgcctcac cggccctgcc ttccgtgccg
    18601 atgtcggcga ccacggtgaa gaccgcaagg ccgatggcgt tgccgatgtt cagggcggtg
    18661 gaggcgaccc cgttggccac gccctgctcc tgcggggcgg tgcccgtcga ggcggcgatc
    18721 cacatcgcgg tccagacgat gccctgtccg acaccggaga cgaccaggcc gggcaccagc
    18781 aggccgtagc ccgcgtcggc gtcgaagccg aacgcgaggg cgaccgtgcc gatcaccccg
    18841 atgccgaagc cgatgaccag ggtggcgcgg gtgcccctcc ggccggcgaa ccgctccccg
    18901 agctgggtac cggcggcgat cgcgagcgac gggatcagga agccgaggcc ggtctgcagg
    18961 gcgctgtagc cgtgcacgct ctgcatcagc acggtgagga agtacggcag gacgccgaag
    19021 gtcgccatgt acaggaaggt gacgagcatc cccacggtga ggcttcggtt gcggaacagc
    19081 cggaacggca tcagcggatc ggcgctgcgc ttctcgatga cggcgaagag gacgagcagg
    19141 acgacggcca ggaggaaggc cccgagcacg aggctgtcgc cccagccccg ctcgggacct
    19201 tcgacgagcg cgaacaccag cagggtcgca ccgccggtga cgctgaggga gccggggagg
    19261 tcgaacgtac ggcgcgcggt gcgggccggg tcgcgcggaa cgacgaacag cgcgcagagc
    19321 gcgatgaggc ctcccagggg aacgttgacg tagaagaccg agggccagcc gaagtgctcg
    19381 gtgagaacgc cgccgaggag ggctccgatg gtcaggccgc tggctccggc gcctccccag
    19441 accgcgaggg cgcggttccg ctcggggcct tcctcgaaca gggtgttgat gagcgagagg
    19501 gtggacggca gcagcagggc accggcgatg ccctgcacgg cacgggccgc gatgatgacc
    19561 tcgcggctgg gggcgaggcc gccggccagg gacgacaccg cgtacagcac gagggcgagg
    19621 acgaacatcc tgcgccggcc cagcagatcg gccgcccgcc cgccgaacag caggaagccg
    19681 ccggcgaaga cgacgtaggc gctcacgacc agttgctggg tctggccggg gaagccgagg
    19741 tcccggccga tctcgggcag cgccacgaac acgatgttca gatcgagggc gtacagcagc
    19801 tgggccaggg ccaggagcgc cagggtccag cccaggtggc gggggacacc gcccggggcc
    19861 cctcgatgcg agcctaagga aacggaagcg gacatggcag atgcctcttt cggggtccgg
    19921 tggggtggcc tggcgcacgc gcgggagggc ccggtgcacg gggcagccca gcgccagtac
    19981 gactgtacgc attcttacgt acgattgatt gttcggcaat ccacgtacag tcgaacccag
    20041 gagggaatgt atgaatgtcg cggtactttg gaaccatgag ccgccaccca gagcgcgacc
    20101 agatccggat cgagagtgtg ctgtccgcgc tgggcagtcc cgtacggctc gccgccgtgc
    20161 gggtcctcga cgcgggcggg gagcacaact gcaccagcgt gctggaactc ctgggcatca
    20221 ccgccaagtc gacgatgacg catcactggc gcgtactgcg cgagagcggc gtcatctggc
    20281 agcacccctc cggcagggag aacctgctgt ccctgcggcg cgacgacctg gacgcgcgct
    20341 accccggcct gctggacgcc gtcctggcgg gggccgccga ggacgcggca ctggagaacg
    20401 cctcggcctc cgcacccgcc ggcccccggg gacgctcgcg cacctgagcg acaccggccg
    20461 ccgtacgccg cccacggatc acccggcgcg gtcctccacc gcccggcctc aggcgggctc
    20521 cggacggagc cgcgccgtca cagcacgccg cccgcctcgt cgtggaagac ctccggccag
    20581 taccggtagt cgtcggggcc ctcggcgggg cggcaggccg tcgggtcgac ggaggacagc
    20641 acctcgatca tggtgtcggc gagctggtgg tagaagtcct gggtgaagtc gtgctcctcg
    20701 tcgaggactt gctcccgctg gtgcagccag agggtgaagg cgagcgtgga gaggtcggtg
    20761 ttgaccggga cgacgtggcc ggcaccggtc tccgcgtaga agagggcgcc ggtccggccg
    20821 tcgacgagga cgctgaagtc gtggaccagc ccgccgagca cgaccaggtg ctcggcgtcg
    20881 ggcggcagcc gctcgtcgcc gtgccagagg tgcgcgtgcc gggggtcgct ctgcgactcg
    20941 gcccagacct gggggagagt gggcagcggc tccggttcgg ggccgtagaa catgaacccg
    21001 tcggagggca ggcccacgtc ggtcaggaat cggcgcgtcg gcgcgtggac gagggccggc
    21061 ggcagctggt cgtccgtgag ccgcaccatg ttcgcggcgc cgaacacccc gtccagcagg
    21121 ccttccggca gttccagggc aagcccccgc ccgggtccgg cgatcagggc gagcggacgg
    21181 atcaccgccg cgatccgcca gaacgccggt atcgggtgct cccagccgga ccgcgggccg
    21241 gccgg
//
