LOCUS       NZ_JAIFIS010000001     26981 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Paenibacillus lautus strain PLV Scaffold_1, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIFIS010000001
VERSION     NZ_JAIFIS010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus lautus
  ORGANISM  Paenibacillus lautus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Endophytic bacteria from Leucojum aestivum L. in vitro plants, a new
            source and elicitor of Amaryllidaceae alkaloids biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-2021) Center for Experimental and Innovative
            Medicine, University of Agriculture in Krakow, Mickiewicza 21,
            Krakow 31-120, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly         :: GCA_003590055.1
            Genome Coverage                   :: 496.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019641495.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 05:30:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,260
            CDSs (total)                      :: 7,166
            Genes (coding)                    :: 7,057
            CDSs (with protein)               :: 7,057
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 2, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 109
            CDSs (without protein)            :: 109
            Pseudo Genes (ambiguous residues) :: 0 of 109
            Pseudo Genes (frameshifted)       :: 38 of 109
            Pseudo Genes (incomplete)         :: 74 of 109
            Pseudo Genes (internal stop)      :: 16 of 109
            Pseudo Genes (multiple problems)  :: 16 of 109
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:25:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5714142
            Orig. end                         :: 5741123
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIFIS010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26981
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="11"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26981
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26981
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16981]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16981
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(312..1625)
                     /locus_tag="K1X09_RS26260"
                     /old_locus_tag="K1X09_26145"
     CDS             complement(312..1625)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006208295.1"
                     /locus_tag="K1X09_RS26260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26145"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_113061542.1"
                     /transl_table=11
                     /translation="MRQHRTTAAVLSAICMGLGQLYNRQWIKGVLLLIVGIFSLYYFIN
                     NLGDAIWGMTTLGEQGSHLEKVNGLTQMVAGDHSINLLIEGLITMIMFALFLIGYYANI
                     KNAYNAGKLREQGGKPNNFRQTLYYIFEWKFAQSFLTLPAIGILFFTVMPIIFMVMLAF
                     TNYSAPNNLPPANLVDWVGFKTFTNLVALKSWSHTFFGVLTWTIIWAVLATVTTYFGGV
                     LVALLIQQKGIRFKGVWRVILIIPYAIPQLISLLVMRNMFNGQFGPINQYLRYFGLEGL
                     PWLTDPVWAKVTVIIVNMWVGIPVSMLLVMSVLTTIPKDLYEAADVDGATGFQKFKIIT
                     LPMILFSTAPVLITQFAGNINNFNLIFLLTNGNPVVGDYQYAGATDLLVTWLYKLTLDQ
                     QRYSMASAIGIIIFMIIATFSIYNYRRTRSFKEEDMIQ"
     gene            complement(1723..3033)
                     /locus_tag="K1X09_RS26265"
                     /old_locus_tag="K1X09_26150"
     CDS             complement(1723..3033)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009592303.1"
                     /locus_tag="K1X09_RS26265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26150"
                     /product="maltose ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_194540976.1"
                     /transl_table=11
                     /translation="MKMKKLLTLAATFTLAFSITACGGNSPAPAAEAPAENPPAQETPA
                     ENTEAPELKPEEGAKLIVWESRDERAYTDAVAKEFTEKYGVEVTIEELSPTDQVTKLQQ
                     DGPSGLGADVVLFPHDNLGKAVATNLVLPNDYFEEKTKSSNSEAAIQGVSYDGVLYGYP
                     RAAETYLMYYNKDLVKEVPTTMEEVIEFSKTFTDKSKNKYGIMFETGNLYFAYPFLASN
                     GGYIFGNGGADVNDIGLNNEGAVKSMEVYASLKEILPVKSGDITPDIKRGLFTAGDLAM
                     DINGPWELGGYKEALGDKLGVAPIPTIGGQPAVSFSGIKAWYVSSFTKYPQAARLFADF
                     ATSKEAQLKLSALVGSVPTNNEAQQDDQIKNDEYVSAFTEQFKSSQPMPSVPEMANVWS
                     PVGAALAEIWDNNKDVKETLDKAVSQVKDLNSGGAGE"
     misc_feature    3083..3094
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.72"
                     /tool="antismash"
     gene            complement(3618..4352)
                     /locus_tag="K1X09_RS26270"
                     /old_locus_tag="K1X09_26155"
     CDS             complement(3618..4352)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="K1X09_RS26270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26155"
                     /product="ABC transporter permease"
                     /protein_id="WP_194540975.1"
                     /transl_table=11
                     /translation="MRMLIRAEGIKLQWSVITVLIVLDTLINSAMGAMQLESLKEFFPP
                     SWLTLYIHSVNLHSMFFYPLYSAIIASLLCLYEHRDGGWKIVMSMPIPRNRLFYAKYMM
                     LIGILGLVQVVFLLGYVATGYLVEAPGEIPWETLLYSIIGGWIGILPLAALQLIVSIRV
                     RNFGASLAMSLGYVVPNIVLTGFHSAIGAWLPFTIPYYVMMPQAALYAPRVEPYSLWFI
                     VLFTGIVYLLMGKRFVEKRDWL"
     gene            complement(4367..5074)
                     /locus_tag="K1X09_RS26275"
                     /old_locus_tag="K1X09_26160"
     CDS             complement(4367..5074)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="K1X09_RS26275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26160"
                     /product="ABC transporter permease"
                     /protein_id="WP_194540974.1"
                     /transl_table=11
                     /translation="MMLELMRAEGLKLKLLCRWMPVIQGIILISMTALEWYLYFRQGPG
                     GIYAGFAVMYMFLSFVFLLGITLLASIMAGTEHETKAWKQLLAMPVPKASVYLAKLLWI
                     LVLQLCAAIITIMGMCLIWVLYSNEPIPWGIMILQPLFACLSTLPMMAIQLWLSTVFSN
                     QALPLALGIFGSITSLFLARSNSLIIQILPWSYPALSSPLIPGHMQWIGISLGVGFMLT
                     VLGALLFARREFE"
     gene            complement(5071..5991)
                     /locus_tag="K1X09_RS26280"
                     /old_locus_tag="K1X09_26165"
     CDS             complement(5071..5991)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="K1X09_RS26280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26165"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_194540973.1"
                     /transl_table=11
                     /translation="MDDYAIDTQELTRRFGKRETVKQINLKVPKREIYGFLGPNGAGKT
                     TTIRMLLGLIRSSSGDIRILGKDLNKYRMDILKDVGSLVESPSYYAHLSGYKNLKIMAL
                     IHGIQESRIQEVLEWVRLSQAAHRPVKSYSLGMKQRLGIAMALITNPKLLILDEPTNGL
                     DPSGIQEIRELITRLPRDFDITVLLSSHLLSEIEQVATWVGIINQGELIFQGPLQELTD
                     RSKPYVWVEMDRPLEAAAALNSQGFDAVPEITTGQIRTSMIDRPQSAEMIRFLVNHQYD
                     VYRVTEKKKTLEEIFLELTGQENSL"
     misc_feature    complement(6045..6062)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.78"
                     /tool="antismash"
     gene            complement(6083..7225)
                     /locus_tag="K1X09_RS26285"
                     /old_locus_tag="K1X09_26170"
     CDS             complement(6083..7225)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019636602.1"
                     /locus_tag="K1X09_RS26285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26170"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_259445462.1"
                     /transl_table=11
                     /translation="MTRMAFRFIKLTVILVMAFVFCFVVSTVIFIYLQDMVNSRNMIST
                     KTFLALIGFVLTILFFIAFGWCVGKPLTYLIRWINRLSKGKYSQPLDHLRKQNGDSNST
                     EGSVGYSYSSGFSSPSSSNSPDDSLHHNHYRYPYVLYKELFDRMSQLSNQLQRSETDRL
                     NAEAKKQEWIAAISHDIKTPLSYVEGYAHMLAAAEYQWTDEERQNFSRQIRDKTAEMKH
                     LIHDLSQTGRWSVEQFPMNKREDDIVNFLRDRMIDIANHPLAEQASFTFNDPESVCMID
                     FDSRLLGRVFQNVLMNAVIHNPPGIEIQCSISIDGKHCIIVIEDNGIGIEKSKLAQALD
                     QSGRGIAIANAFVEAHAGCMSILPAEGKGTRVEIVLPVRL"
     gene            complement(7231..7947)
                     /locus_tag="K1X09_RS26290"
                     /old_locus_tag="K1X09_26175"
     CDS             complement(7231..7947)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="K1X09_RS26290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26175"
                     /product="response regulator transcription factor"
                     /protein_id="WP_220686518.1"
                     /transl_table=11
                     /translation="MDNMSVLLVDDEQGLCDMLTSVLKKEGFRHIRSVGTGQEAVRILS
                     EFNPDVIILDVMLPDEDGFEVCRKIRKITETPILFLTARDADLDKLMGFGIGGDDYITK
                     PFNPLEVVARTKARLKYKTRQKQDVQPRLTSLDFGYFRLDLAAGELIVDGKQVECPARE
                     WELLVFLCRHPNRIFSTRQLYESVWQESYLGDEKTVVIHIFRLRKRMEPDPGNPQFLVN
                     VRGLGYKMLAPRKEQE"
     gene            complement(8119..10014)
                     /locus_tag="K1X09_RS26295"
                     /old_locus_tag="K1X09_26180"
     CDS             complement(8119..10014)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="K1X09_RS26295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26180"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_259445463.1"
                     /transl_table=11
                     /translation="MLSPDTNMKDEYVSFSSKNIFRTFLFWPRIFKLLWETHAGYLIGI
                     LISNLFKGILPAIVLLATRELINSVVGSVPHGDFRPVLLAFGLLMLLNILSDFIGIVDG
                     YFRKMFQSLLSNRVNLKLIEKAHQMTLQSFEDADVQNKLQRAQGEANYRPFEIFVQMLG
                     IISGVVTLVSASAILIAWKWWAIFVIILIPCLSFYSFLKIGQREFNTYYQRAGKQRESW
                     YLSFLVTRDNSFKEIKIFQLGNYLRERYLSILNGFHLEDKKLASRRSYTSLIFQVINQI
                     ACGFIIFLAVRSAFIGQIMLGYLISFIQAINLTQSTSQNIVQGILSLCQNNLYVKQLFD
                     FLDMPEEEEVEEIEQRISYIHSIEFRNVSFKYPNTNKNAISNISFMLNRNEKLAIVGKN
                     GSGKSTIVKLITQLYSNFEGDILINGQSIRDLNKESFREKMGVVFQDFVQYEMTVKDNV
                     GFGDVNQKENDQVVWKAIEQSGITKLINTLPNKLNTMLGKWFDEGQQLSGGQWQRVAIA
                     RAFMRNADVYILDEPSSYLDPHSEKEVFNKFEQLTHQKIGVFISHRLSSAKTADNIILL
                     EEGRIIEAGNHDSLMRLNGTYAEMFGIQASSYLSSDEEETLEEAVISSFVSTSAE"
     gene            complement(10001..13231)
                     /locus_tag="K1X09_RS26300"
                     /old_locus_tag="K1X09_26185"
     CDS             complement(10001..13231)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820473.1"
                     /locus_tag="K1X09_RS26300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26185"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_259445464.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.2e-177,
                     bitscore: 589.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.2e-14,
                     bitscore: 51.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.4e-38, bitscore:
                     129.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKEQSSLNDVATHNMYEEQKQSERWFKPCDFFIVRTPLLPLDTY
                     LQVISEHNFQSEKAVPETIRRLKEETSTSIVKEAISIASPSLRSFYEFLNIPTDEADKK
                     TTQKVEKTLISLLRYFIRMSTRTTPFGLFSRVVQGHFGDRSDLEVCSFSENQKRARPDM
                     EWMFHLIKLMESDPVIFDELKVRMNRTLMIKGNRVKLPFRPQYGILNLEAIPEGANSIG
                     LTEVVGLTLQAAREPIDVKTLKKAILEAFPESNLDIIHNYLRQLLEQEFLISELRPPLM
                     DVPPLEHIGTVLSGISGSDKWLETLSEVQALLLQYETSKIGSGEGIYRQLTEKMVDVVK
                     TSNLVQVDVRLKKDVTLPRSITNDVVLGAELMCKLHVPEGHELNEYLNRFLEKYGVYQE
                     IPINELFDSDWGLGIPKAYQPDFTSETQQVSYTRNSILFQLVTEAIAQGSAECVLTDEH
                     IQELTLNHDPQNAPESLEIYYSLVADSQEQVDRGDYKLVLGASAGSSGAGKTFGRFLDM
                     FDPSFIQNFEQIHSHVQRLHPQAAIAEMVFMPSSGRISNIMIGKNLSEYEIVSGTNSSK
                     NELNTLHIDDLLVGATYDRFYIKSKKLGREIIPLQTHMFNHRISPPIFRFLSDITRKLT
                     KTWSYFNWGPVEQSPFLPRLRYKSIILSSAQWRLGKHTMGVEQSGGSKEWLDKFYSWKE
                     RWKVPRYIYLAMGDNRLLLDLHNQLCIEELRREMGKLQNGQELLLTECMNHPSCSPLHS
                     KGETYTGEFVFPVLNTKSVPQSIPKRGIFDDSGYQPIASRGVLPGEDWLYIKLYGTSER
                     EAELLGLHLDDLWKQPEFNNWSRRFYFVRYRDQESHIRLRFNGDSKELWSTGIGQISQW
                     MKRLRNSGLAVSMTIDTYVPEFERYGGEGLIEIAEGVFAADSKLVSLYLGEVRRKRLNL
                     VPEVIAVANILDILAGFGLTFEEQKKWLEERVDGKKHMKAYRELKKTLIEAADSNPAWL
                     YKMDASNLIIAALDERRALIKTYAESIENAKHKGLTNHPHDILASLVHMHLNRLLGVDR
                     ELEIKCMALAKYTAAHFYHAKGALHVIS"
     aSDomain        complement(12395..12679)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K1X09_RS26300_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-16"
                     /identifier="RREFam001.1"
                     /label="K1X09_RS26300"
                     /locus_tag="K1X09_RS26300"
                     /protein_end="279"
                     /protein_start="184"
                     /score="51.6"
                     /tool="antismash"
                     /translation="VRMNRTLMIKGNRVKLPFRPQYGILNLEAIPEGANSIGLTEVVGL
                     TLQAAREPIDVKTLKKAILEAFPESNLDIIHNYLRQLLEQEFLISELRPP"
     gene            complement(13203..13886)
                     /locus_tag="K1X09_RS26305"
                     /old_locus_tag="K1X09_26190"
     CDS             complement(13203..13886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="K1X09_RS26305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26190"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_220686519.1"
                     /transl_table=11
                     /translation="MKKTIVAVSPDSPIKVFLNQITHSSNIEVLSCDSFNQIETIADHR
                     CMGVFVCQNNITMKDLSIWHKLREKSAVPFIFLTPGSNEQLEYEILNQLFSLTARTDAK
                     KASAEREVIYLSPNVIFDRSCKVIWKQGEGHMLTLMEYRLLEYFLESRDWVIDIDHIIN
                     KVWGVDTFTSSNTVYVHIRKLREKIEEDPSNPKILVTCHGLGYRMNIMNNMLEVHHDER
                     TVQLK"
     misc_feature    complement(13848..13863)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(13927..15177)
                     /locus_tag="K1X09_RS26310"
                     /old_locus_tag="K1X09_26195"
     CDS             complement(13927..15177)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="K1X09_RS26310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26195"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_220686520.1"
                     /sec_met_domain="LANC_like (E-value: 7.4e-54, bitscore:
                     181.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSCLQEQSIRISKFIAERLVDLSYIENITKSPENHSPSRGAAP
                     WNPISLADGIPGIWVLFAEWDRLEPDRGWKQSIHQHLLSLYRAMPLCIPDISLFSGVTG
                     VAYGLFMASDDHKNYIKTRSQLNQYIASQFKAGRTIPGLDSLDVVSGLCGVARYVLETY
                     RYDDGMCEIAVPLMTNIIKESVTIIDSAIYGTDRQVQNGLAHGLAGILALLVTADHKQV
                     EVENLQHTIHRIANYLVQQTREDQYGRFWPISSNTSGLAQNEKKEARQIEGWCHGTLGI
                     SLTLWRAGVQCGNEDWKKLAAEAAGSAFRLGERELGFMTPSFCHGLTGLLHLANHFHRL
                     CDIPEASLFAEKVASRLMYMFDESSPFGYRDQEDTVCTDNPGLLQGAVGIALSLLDYGK
                     RDDPMYLGKWREVFLMS"
     gene            complement(15268..15420)
                     /locus_tag="K1X09_RS26315"
                     /old_locus_tag="K1X09_26200"
     CDS             complement(15268..15420)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="K1X09_RS26315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26200"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_220686521.1"
                     /sec_met_domain="TIGR03731 (E-value: 3e-05, bitscore: 22.5,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNQFDLDLQVAQNEVAPNEVQPASGLICTPSCLTGTLNCKISLS
                     FCRTC"
     CDS_motif       complement(15349..15420)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNQFDLDLQVAQNEVAPNEVQPA"
                     /locus_tag="K1X09_RS26315_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15268..15348)
                     /prepeptide="core"
                     /locus_tag="K1X09_RS26315_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.00"
                     /molecular_weight="2578.1"
                     /monoisotopic_mass="2576.3"
                     /core_sequence="SGLICTPSCLTGTLNCKISLSFCRTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNQFDLDLQVAQNEVAPNEVQPA"
                     /leader_location="[15348:15420](-)"
                     /alternative_weights="2596.1"
                     /alternative_weights="2614.1"
                     /alternative_weights="2632.2"
     gene            15614..16981
                     /locus_tag="K1X09_RS26320"
                     /old_locus_tag="K1X09_26205"
     CDS             15614..16981
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="K1X09_RS26320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26205"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_259445465.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-55, bitscore:
                     185.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDMLDVKEQNSTYIYEKGLEISKEIAIRLSDPKFVFDSVHTRD
                     NVMTETGHFPWGDISLSHGYPGNIHLLTQWRRIDKSMNWSQAIHSNMVEIQSYLSRFGT
                     GDISLYSGWAGIASAVYAASNQGEFYNQFLNQIHRWMSPLVEQWLRTSTEILQQKNGVP
                     VELYDTISGASGVGRYLLKNAADPVVAPLIEPLLRFLVELTEPIYINDKLVPGWFTPSK
                     FQSSAGDKSSFPVGSFNCGMAHGIPGPLALLSIAYNNGIEVPGQYRAIENITEWLLDSQ
                     EEDELGSYWPHIIPFEELITKNKLLRQREAWCYGTPGVTCALYISSISLNNPAIAQTAL
                     KSFINAVSYECDRNRMDSPSLCHGLSGLLLMSKRMWHSTKDPAITILIDQLMTKLLQRF
                     DSSTPLGYKDAEPGVANTIRWLTKAGLLEGVAGIAATLQGTGEADQNDWDYMLMLS"
     gene            complement(17214..18482)
                     /gene="purD"
                     /locus_tag="K1X09_RS26325"
                     /old_locus_tag="K1X09_26210"
     CDS             complement(17214..18482)
                     /EC_number="6.3.4.13"
                     /GO_function="GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819774.1"
                     /locus_tag="K1X09_RS26325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26210"
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="WP_220686522.1"
                     /sec_met_domain="ATP-grasp (E-value: 1.7e-06, bitscore:
                     26.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.2e-06, bitscore:
                     25.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDILVIGGGGREHAIVWALAKSPKADKIYCAPGNAGIGQLAECVP
                     IAVSEFEKLAAFAVEKQVGLIVVGPDDPLADGIVDAFDATGIPVFGPRKNAAEIEGSKT
                     FMKDLLHKYGIPTAAYAKFDDYEKALAYLRQQGAPIVVKADGLAAGKGVTVARTIEEAE
                     QALSDIMQSKVFGDAGSRVVIEEFLEGQEMSILAFVDGETVKPMSAAQDHKPAYDGDLG
                     PNTGGMGTYSPLPHIQSSVIEEAIETIIKPTAKAMVAEGRPFRGVLFAGLMITPDGKPK
                     TIEFNARFGDPETQVVLPRLKTDLLEVFLAAVNGNLADLELEWSDEAAVCVILASGGYP
                     ASYPKGIAISGLDNEQDGTIVFHAGTSRDADGTWRTNGGRVLGVVGLGADIASARAKAY
                     ERAEAILFEGKQNRTDIALKALV"
     gene            complement(18701..20248)
                     /gene="purH"
                     /locus_tag="K1X09_RS26330"
                     /old_locus_tag="K1X09_26215"
     CDS             complement(18701..20248)
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0003937 - IMP cyclohydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004643 -
                     phosphoribosylaminoimidazolecarboxamide formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006208291.1"
                     /locus_tag="K1X09_RS26330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26215"
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="WP_220686523.1"
                     /transl_table=11
                     /translation="MGIKRALVSVSDKTGIVEFCRELSSLGVEIISTGGTKNLLAKEGV
                     PVIGISDVTGFPEILDGRVKTLHPAVHSGLLAIRDSEEHQRQMQELGLDYIDLVVVNLY
                     PFQETIAKPGVEYEDAIENIDIGGPTMLRSAAKNHAFVSVVVDAADYGSVIEEIRDGGD
                     TTLETRKRLAAKVFRHTAAYDTLISDYLSNVTGDPLPERFSVTYEKIQDLRYGENPHQK
                     AAFYRKPLAPAGTLTTAEQLHGKELSYNNINDANAALQIVKEFDEPTVVAVKHMNPCGV
                     GIGTNVLEAYQKAYNADPTSIFGGIVAANRTIDAPTADLLKDIFLEIILAPDFTPEALE
                     IITKKKNIRLLKMGEFGSAKERQSTLAVTTIEGGMIVQESDVHSLDAADLKVATDRKPT
                     EEELKQLLFGWKVVKHVKSNAIVLAADNMTVGVGAGQMNRVGSARIAVEQAGEKAKGAV
                     LASDAFFPMGDTVELAAKAGITAIIQPGGSIKDEESIKAANEYGIAMVFTGVRHFKH"
     misc_feature    20349..20363
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(20400..21011)
                     /gene="purN"
                     /locus_tag="K1X09_RS26335"
                     /old_locus_tag="K1X09_26220"
     CDS             complement(20400..21011)
                     /EC_number="2.1.2.2"
                     /GO_function="GO:0004644 - phosphoribosylglycinamide
                     formyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228: methionyl-tRNA formyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012819098.1"
                     /locus_tag="K1X09_RS26335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26220"
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="WP_071221557.1"
                     /transl_table=11
                     /translation="MRPFRIAVFASGRGSNFQALVDTQHRGALGGVISILVCDKPQAPV
                     VELAQAANVDVFAFQPKDYASKEDYEREIAVELQQRGVELIVLAGYMRLLSPSFVEFYS
                     GRIINIHPSLLPAFPGKDAIGQALDYGVKMTGVTVHFVDGGMDTGPVIAQKAVEIKEGE
                     TAEVLAERIHAVEQKLYSEVVSWFAQGRISLNGRNVTITE"
     gene            complement(21011..22051)
                     /gene="purM"
                     /locus_tag="K1X09_RS26340"
                     /old_locus_tag="K1X09_26225"
     CDS             complement(21011..22051)
                     /EC_number="6.3.3.1"
                     /GO_function="GO:0004641 -
                     phosphoribosylformylglycinamidine cyclo-ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819771.1"
                     /locus_tag="K1X09_RS26340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26225"
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="WP_194540968.1"
                     /transl_table=11
                     /translation="MSDTYKQAGVDIAAGNEAVERMKKHVKTTFRPEVMTDLGGFGALF
                     KLNKDQYEEPVLVSGTDGVGTKLKLAFAMDQHDTIGIDAVAMCVNDIVVQGAEPLFFLD
                     YLACDKVIPSKIESIVKGIADGCNQAGCSLIGGETAEMPGMYSEGEYDIAGFTVGIVDK
                     SKMINGSNIAAGDAVIGLASSGVHSNGFSLVRKLLLEDAGYSLQQELPELGGRLGDVLL
                     APTKIYVKPLLGLLKEIEVKGMAHITGGGFIENIPRMLPDGVNVDIEYGSWPILPIFKL
                     MQEKGSISNKDMFTTFNMGIGMVLVVKEQDADGVLQYLRSAGEEAYVIGRVTEGERIVT
                     FTGAEV"
     gene            complement(22230..23708)
                     /gene="purF"
                     /locus_tag="K1X09_RS26345"
                     /old_locus_tag="K1X09_26230"
     CDS             complement(22230..23708)
                     /EC_number="2.4.2.14"
                     /GO_function="GO:0004044 - amidophosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007132727.1"
                     /locus_tag="K1X09_RS26345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26230"
                     /product="amidophosphoribosyltransferase"
                     /protein_id="WP_145039121.1"
                     /sec_met_domain="GATase_7 (E-value: 4.5e-25, bitscore:
                     86.6, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHELIPEGLWTGDYYNEGTGQSDIFDTLKEECGVFGVFGHPDAA
                     SLSYYGLHALQHRGEESAGICVADGENFNYHRGMGLVKEVFDKDKLESLQGSMSIGHVR
                     YSTSGDSRLTNAQPLVFKYREGNLAIATNGNIVNEPKLRRELEMEGSIFQTTSDTEVIA
                     HLIARSPKDFVEAAKDALQRLVGGFAFLLMTNDKLLVASDPNGLRPLTMGRLGDAYIFT
                     SETCALEVIGAEAIRDVAPGELLILDRNGLREERYTEAGRKALCAMEYIYFSRPDSDLN
                     GSNLHSARKRMGSKMALESFVDADVVTGVPDSSISAAIGYAEQTGIPYELGLIKNKYTG
                     RTFIQPSQELREQGVKMKLSAVRRVVEGKRVVMIDDSIVRGTTSRRIVNLLREAGATEV
                     HVRITSPPFKNPCFYGIDTPDRRELIASEKSVEEICREINADSLSFLSPEGLISAIGGY
                     DEHSPKGGLCMACFDNDYPTQIDFNGEEKMGCSC"
     gene            complement(23693..25936)
                     /gene="purL"
                     /locus_tag="K1X09_RS26350"
                     /old_locus_tag="K1X09_26235"
     CDS             complement(23693..25936)
                     /EC_number="6.3.5.3"
                     /GO_function="GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012819096.1"
                     /locus_tag="K1X09_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26235"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurL"
                     /protein_id="WP_220686524.1"
                     /transl_table=11
                     /translation="MAQQTSVKEPTAEQIAEHQIYKQMGVSDSEYELICSFMGRKPNYT
                     EIGVFSVMWSEHCAYKNSKPLLRRFPTSGPRVLMGPGEGAGIVDIGDNQAVVFKIESHN
                     HPSAVEPYQGAATGVGGIIRDIFSMGARPVAILNSLRFGKLESDRVKYLFEHVVSGIAG
                     YGNCIGIPTVGGEVVFDESYEGNPLVNAMCVGVIDHDKIQRGVAKGVGNPVFYVGPPTG
                     RDGIHGATFASVELTEESEANRTAVQVGDPFMEKLVMESCLELIDSGIVLGIQDMGAAG
                     LTCSSAEMASKAGNGLELYLDQVPQREEGMTPYEMMLSESQERMLFVVEPKHEEQAREI
                     FERWGVICAKVGKVTDDGRLKLIHHGEVVGDMPVKALVDECPIYNKPSQEPAYYQEQAA
                     VDMLRYEEVKDLGGALKKVLGSPSLASKAWVYNQYDYMVRTSTAVRPGSDAAVVTVPGT
                     RKALAMTTDCNGRYVYLDPELGGRIAVSEAARNIVCSGAEPLAITDNLNFGSPEKPEIF
                     WQMEKAVDGMAEACRELETPVIGGNVSLYNENAKGAIYPTPVVGMVGLIHDTDHITTQG
                     FKAEGDAIYVLGDTRAELGGSEFQAIMHGVSEGRPPELNLDTEKKLLGGVLKAIQSGLV
                     QSAHDVSEGGLAAALAESCISGNVGASVQWSTDLRNDVALFSESQSRIVLSVSPDHKNA
                     LEKLLQEAGVPFTALGVVGGNKLSININGASALEESVEALKSVWEDAIPCLMN"
     gene            complement(25914..26603)
                     /gene="purQ"
                     /locus_tag="K1X09_RS26355"
                     /old_locus_tag="K1X09_26240"
     CDS             complement(25914..26603)
                     /EC_number="3.5.1.2"
                     /EC_number="6.3.5.3"
                     /GO_function="GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279842.1"
                     /locus_tag="K1X09_RS26355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26240"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurQ"
                     /protein_id="WP_100540297.1"
                     /transl_table=11
                     /translation="MRFAVLVFPGSNCDIDCYKAVEETIGQPVDYVWHTATDLSPYDCI
                     LVPGGFSYGDYLRCGAISRFAPVMSEVAKAAEEGKYILGICNGFQILTEAGLLPGALRR
                     NDSMKFRCHDTVLKVNNNTTPFTRDYAEGQEIVIPIAHGEGNYYCDEETLQKLRDNRQI
                     VFTYQNNPNGSIEDIAGICNERGNVIGMMPHPERAVSSLLGSDDGKAMFTSILQAWRDT
                     HGAANVR"
     gene            complement(26608..26853)
                     /gene="purS"
                     /locus_tag="K1X09_RS26360"
                     /old_locus_tag="K1X09_26245"
     CDS             complement(26608..26853)
                     /EC_number="6.3.5.3"
                     /codon_start=1
                     /gene="purS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018753696.1"
                     /locus_tag="K1X09_RS26360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_26245"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurS"
                     /protein_id="WP_012819094.1"
                     /transl_table=11
                     /translation="MLKAKVYVTIKQSVLDPQGVAVQGALHSIGYKEVESLRIGKYMEL
                     ELGTDNREEAELRVKEMCEKLLANTVVENYRYELEG"
ORIGIN
        1 tttaaaccgg aatcgggaga ccgcataact tgtgagcagg acaagaatgg tcccaataat
       61 catggagaat atcgcaattt tcaacgtgtt catgtaccat gtgccaaaca gaaagctctg
      121 ggacgtaaac aattctttat aatgactgag cgtaaaagat tctggaatca aggacttgct
      181 gtacaacgac tttccgggac ggaaagaggc cagaacaatc cagagcgccg ggtaaataca
      241 accgatcgca atgatgacaa gcgtgatgta acttgccgtc aggcgaatcg catttctcat
      301 tttaattccc attattggat catatcctcc tctttaaagg atctggttct gcgataattg
      361 taaatcgaga aggtcgcaat aatcatgaag atgataatac cgatggccga tgccatgctg
      421 taccgctgct gatccagcgt cagtttatag agccaggtta ccagcaggtc cgtcgcaccc
      481 gcgtattgat aatcacccac aaccgggtta ccgtttgtca ggagaaaaat caagttaaag
      541 ttgttaatgt taccggcaaa ttgcgtaatc agcaccggtg ccgtcgagaa caaaatcatc
      601 ggcagggtga tgatcttgaa tttctggaat ccagtcgccc cgtccacatc ggccgcttca
      661 taaagatcct tcggaatcgt agtcaggaca ctcataacga gaagcatgga taccgggata
      721 cctacccaca tattaacgat aataacggtc actttggccc agaccggatc ggtcagccat
      781 ggcaggcctt ccaaaccgaa atatcttaaa tactggttga tcggtccgaa ttgcccgtta
      841 aacatattac gcatgacgag caaggaaatc agctgcggaa tcgcatatgg aatgatcaga
      901 atgacacgcc atacgccttt gaaacgaatt cctttttgtt gaataaggag tgcaacgagc
      961 acaccgccaa aatacgtcgt taccgttgcc agcactgccc agatgatcgt ccaggtcagg
     1021 acgccgaaga acgtatggct ccatgatttc aatgcaacga gattggtgaa ggttttgaaa
     1081 ccgacccagt caaccaaatt tgccggcggc agattgtttg gagcagaata gttcgtaaac
     1141 gccagcatga ccatgaagat aatcggcatg accgtaaaaa acaaaatacc gatggccggc
     1201 agcgtcagga aagattgcgc gaatttccat tcaaaaatat agtaaagggt ctgtctgaag
     1261 ttgttgggtt ttccaccctg ttcccttagt tttccagcgt tatatgcgtt tttgatattg
     1321 gcataatacc caataagaaa aagcgcaaac ataatcatgg tgataagtcc ttcaatcagc
     1381 agattgatgg aatggtcacc tgctaccatt tgggttaatc cgttgacttt ctctaaatgg
     1441 cttccctgtt cccccaaagt tgtcattccc cagatggcat cacccaggtt gttgatgaag
     1501 taatacagac tgaatatacc tacgataagt aaaagaacgc ctttgatcca ttgccgattg
     1561 taaagctgac ccagacccat acagatggct gataatacgg ctgctgtcgt acgatgttga
     1621 cgcatgctcc ctccattctc ctctccatat aatcgaggaa tcacccgccg gttgttcggc
     1681 gggtgaactt cttcatctat ctcgcattat ataagaacgt aattactcgc cagctccacc
     1741 actgttgaga tctttcactt gacttacagc tttatcaagc gtttctttca cgtctttgtt
     1801 gttatcccag atctcagcca gtgcagcgcc tacaggagac catacgttag ccatttcagg
     1861 aacggatggc atcggttggg aagatttgaa ctgctctgtg aatgccgata catactcgtc
     1921 attcttgatt tgatcatctt gttgagcttc gttgttagtt ggaaccgatc caaccagtgc
     1981 gctcagtttc aattgagctt ccttgcttgt cgcaaagtca gcgaacaaac gagcggcttg
     2041 cggatatttc gtgaacgagc ttacgtacca agctttgata ccggagaacg atacagcagg
     2101 ctgaccgccg atggttggga ttggagcaac gccaagcttg tcgccaagcg cttctttgta
     2161 tccgccgagc tcccatggtc cgttaatgtc catagccagg tcgccggccg tgaacaatcc
     2221 gcgtttgata tcaggcgtaa tgtcgccgga tttaaccgga agaatttctt tcaggcttgc
     2281 atacacttcc atactcttga ctgcgccttc gttgttgagg ccgatatcgt tgacatctgc
     2341 gccgccgtta ccgaagatgt agccgccatt ggaagcaagg aatggatatg cgaagtacag
     2401 gttgcctgtt tcgaacatga ttccatattt gtttttggat ttgtctgtga aggttttgct
     2461 gaactcaata acttcttcca tcgttgttgg aacttctttt accaggtcct tgttgtaata
     2521 catcaggtat gtttcagcag cgcgcgggta tccgtacaga acaccgtcat agcttacgcc
     2581 ttggatagcg gcttccgagt tgctgctctt cgttttttct tcgaagtaat catttggcag
     2641 aaccaggttg gtagctacgg ccttacccag attatcgtga gggaacaata caacgtcagc
     2701 gcccaatccg gatggcccgt cttgttgaag cttggtaact tggtcggttg gggacaattc
     2761 ttcgatggtt acttcaacgc cgtatttctc ggtaaattct ttagcaaccg catcggtgta
     2821 ggctctttcg tctctacttt cccatacgat caatttagcg ccttcctccg gcttaagttc
     2881 cggtgcttct gtattttcgg ccggcgtctc ctgggctggt ggattctcag caggtgcctc
     2941 agcagcggga gcaggtgaat ttcctccgca cgctgtaatg gagaacgcca acgtgaaggt
     3001 tgcagctagc gtaagtagtt tcttcatctt cattccatga ttacccctct caataaatga
     3061 tcagaaaatg ttggaaatct gcgcaaacga tttcagaaat tttcagcgtc tctttttcta
     3121 tgtagcatct ggcgagatac tcaggaaaaa tcccgttgag aaagcgcttc attcactgaa
     3181 aacatcatac aacatttatt atcgaatgta aaaacgtttg cacagatcat ttttacccgt
     3241 tttatgcata taatctcttg ttaccttcac tattcgctgt atttcgtaag ttatcataaa
     3301 aatagttgag catatgcagt gcaattcagt cattctactc cccaaatcgg acaagaatgg
     3361 ctgcaaaacg ctccaatgtt gcacaaacgt ttgcgcaata gttgcgcttc tttctttcac
     3421 tgatatatat accattgacg cccttaagat tagacgtcac cccggttaga aagtagccca
     3481 gccccatcct tatctttcat atgcgttaat aagcttgatt attccgtgac cagggggcct
     3541 tagaatataa tagaccctgg tgtttgctgc accagggcta aagaaactta tttattatca
     3601 atatgctagc aaatgggcta caaccaatct cttttttcaa caaaacgctt ccccattaac
     3661 aaatatacga tacctgtaaa taacacgatg aaccacaggc tataaggttc aactcgcggc
     3721 gcgtagagcg ctgcctgtgg catcatgaca tagtagggaa tcgtgaatgg aagccaagcc
     3781 ccaatggcag aatgaaaacc tgtcagcacg atattcggca ccacatatcc cagagacatc
     3841 gccagggagg ctccaaaatt ccgaactctt attgaaacga taagctgtaa ggcagcaaga
     3901 ggtaaaatac cgatccatcc tccgataatg gaatagagta acgtctccca cggaatctca
     3961 ccaggcgctt caacaagata tcccgttgct acataaccga gtaaaaaaac gacctgcacc
     4021 agccccaaaa tcccaatgag catcatatat tttgcataga agagcctgtt gcgggggatc
     4081 ggcatactca tgactatctt ccagcccccg tcccggtgct catataagca taataaggag
     4141 gctataattg cgctgtacaa aggatagaaa aacatagagt gtaaattaac gctatggata
     4201 tagagcgtca accagctggg cgggaaaaat tcctttaagc tctcaagctg catcgctccc
     4261 atcgctgagt taatcagcgt gtccaatacg atgagcactg tgatgacact ccattgaagc
     4321 ttgattcctt cagcacgtat cagcattctc ataatggcag caccccctat tcaaattctc
     4381 ttctggcaaa caggagagct cccagcaccg tcagcatgaa ccctactcca agtgagattc
     4441 ctatccactg catatggcca gggatcagcg ggctggatag tgccggatac gaccagggaa
     4501 ggatttgaat gataagagaa ttgcttcgcg ctaaaaacaa gctggttatg gagccgaata
     4561 tcccgagagc cagcggtaaa gcctggttcg aaaacaccgt ggacagccag agctgaatag
     4621 ccatcatcgg caatgtcgat aagcaggcga acagaggctg caatatcatg attccccaag
     4681 gtatcggttc attcgaatac agaacccaaa tcaggcacat ccccatgatc gtaatgattg
     4741 cggcacataa ctgtaataca aggatccata aaagtttagc cagatacaca gacgctttgg
     4801 gaacaggcat cgcaagcagc tgcttccatg ccttggtttc gtgctcggta ccggccataa
     4861 tgctggctag aagcgtaatc cccaataaaa aaacgaaaga caaaaacatg tacatgaccg
     4921 caaagccggc atagattcca cctggacctt gacgaaaata aagataccac tccaaggccg
     4981 tcatgctgat caggattatg ccctggatta caggcatcca ccggcataat aacttaagtt
     5041 ttaatccttc tgcacgcatc agctccagca tcataagctg ttctcctgac cggttaattc
     5101 caggaagatt tcctcaaggg ttttcttctt ctccgttacc cggtagacat catactgatg
     5161 attgacaagg aaacgaatca tttcggctga ttgcggcctg tcgatcatgg aggtacggat
     5221 ctgacctgtt gttatttccg gcaccgcatc aaagccttga ctattcagag ctgctgctgc
     5281 ttccaggggc cggtccatct ccacccagac ataaggctta ctgcgatccg ttaattcctg
     5341 cagcggtcct tggaagatca attccccttg attaataatt cctacccacg ttgcaacctg
     5401 ctcgatttca ctcagcaaat ggcttgaaag cagtacagtg atatcaaaat cgcggggaag
     5461 tcgtgtaatc agctctcgaa tttcttgaat tcccgatgga tcaagtccat ttgtgggctc
     5521 atctagaatc aacaatttgg gatttgtaat aagcgccatc gcgatcccaa gccgctgctt
     5581 cataccaaga gaataacttt tgaccggccg atgagccgcc tggctcagtc tcacccattc
     5641 cagaacctcc tgaatcctgg attcttgtat tccatggatt aacgccataa tcttcagatt
     5701 cttatatcct gataggtgag catagtatga aggggattct acgagagaac cgacatcctt
     5761 taaaatgtcc attctgtact tgttcagatc cttgcctagg atacgaatat cacctgatga
     5821 cgaacggatc agtccaagga gcattcgaat ggttgttgtt ttaccagcgc cattgggccc
     5881 cagaaatcca tagatttccc gcttagggac cttcaaatta atctgcttaa ccgtttcccg
     5941 cttcccgaac cgtcgggtca actcctgtgt atcgattgca taatcgtcca ttattaattc
     6001 ctcctgcttg gcattgctaa tactttaagt ttagcaacgg aaaattaaca acaggtaaac
     6061 aaggaatgaa cgatataata atttacaggc ggaccggcaa cacaatttca acacgggtgc
     6121 ccttaccctc tgcgggcaga atgctcatgc agcctgcatg ggcttccaca aaggcattgg
     6181 ctatagcgat tcctctaccg gattgatcca aagcctgtgc taactttgat ttctcgatcc
     6241 cgattccatt atcctcaatc acgatgatgc aatgctttcc gtctatagag atactgcact
     6301 gaatctcaat accgggcgga ttatgtataa ccgcattcat gagtacattt tgaaagactc
     6361 tgcctaacaa tctgctgtca aaatcgatca tgcacacgct ctctgggtca ttaaacgtaa
     6421 acgaagcttg ctcggctaac gggtggtttg caatatcgat cattcgatca cgcagaaaat
     6481 tcacgatatc atcctccctc ttattcatag ggaactgttc gacagaccat cggcccgttt
     6541 gactcaaatc gtggattaga tgtttcattt ccgctgtctt gtcacgaatc tgcctgctaa
     6601 aattctgcct ttcttcatcg gtccattgat attcggccgc cgcgagcata tgagcatagc
     6661 cttcgacgta ggacagtggc gtcttgatgt catggctgat cgcagcgatc cattcctgct
     6721 tcttcgcctc cgcatttaat cgatcggtct cgctgcgctg taattgattc gataattgac
     6781 tcattcgatc aaataattct ttgtataaca cataaggata ccgataatgg ttatgatgta
     6841 gtgagtcatc ggggctattg gagctgctgg ggctgctgaa gccactggag taactgtagc
     6901 caacagagcc ctcggtgcta ttggagtcac cgttttgctt gcgcaaatgg tccagcggct
     6961 ggctgtattt ccccttcgat aatcggttga tccaacggat taagtaagtg agcggtttgc
     7021 ctacgcacca gccaaatgca ataaaaaata gaatagttag cacaaatccg ataagagcta
     7081 aaaaagtctt cgtggatatc atgttccggg aattcaccat gtcctgcaaa tagatgaata
     7141 taaccgtgct cacgacaaaa caaaagacaa atgccatcac caaaataacg gttagcttga
     7201 taaagcgaaa ggccatcctg gtcatcggat tcactcctgc tccttcctag gggccaacat
     7261 tttgtagcca agtcctctta cgttaacaag aaactgagga tttccgggat cgggctccat
     7321 cctttttcgc agtctgaaga tatgaatgac aaccgtcttc tcatctccaa ggtaggattc
     7381 ctgccagacc gattcgtata attgccttgt gctaaaaatg cggtttggat gtcggcataa
     7441 gaatacaagc agctcccatt cacgtgccgg gcactccact tgtttgccat ccacgatcag
     7501 ttctccggct gcaagatcca gccgaaaata accaaagtca agactagtca atcgtggttg
     7561 aacatcttgt ttttgccgtg ttttatactt tagacgagct ttggtgcggg caacgacctc
     7621 caatggattg aatggcttcg taatataatc atccccgcca atgccaaacc ccatcagctt
     7681 gtccaagtca gcgtcccgtg cagtaagaaa gagaatcggc gtttcggtta ttttgcggat
     7741 tttccggcac acctcgaaac cgtcctcatc cgggagcatg acatccagta tgattacgtc
     7801 cggattaaac tccgataata ttctcaccgc ttcctgcccc gtgcccacgc ttcgaatatg
     7861 ccgaaagcct tccttcttca gcacgctagt caacatatca cataaccctt gttcatcatc
     7921 cacaagcagt acagacatat tatccatagc atttttctcc attattttca taattctaca
     7981 aacctttaac tgtattatat aacagagaga caatataata agcccatttc tggattcttg
     8041 ttaataaaag gatgaataac cgaccacctc ttacaacaga atccagaatg ggcttctgta
     8101 ctttggctga accatatatt attcggccga agtgctaacg aaagaagata taaccgcttc
     8161 ttccaaagtc tcttcctcat cagacgagag ataggaggaa gcttgaattc caaacatttc
     8221 tgcatacgtt ccatttaatc tcatcaggct atcgtggttg ccggcctcaa taattcggcc
     8281 ctcttccaac aatataatgt tatcggctgt tttcgcagaa gataatcgat gagagataaa
     8341 aaccccgatt ttttgatgag tcaattgctc aaacttgtta aaaacctcct tttctgaatg
     8401 aggatctaga tatgagcttg gttcgtccaa aatataaaca tctgcattcc tcataaatgc
     8461 tcttgcgatc gcaacacgtt gccattgtcc acccgatagc tgctggccct cgtcaaacca
     8521 ttttccaagc atcgtattta atttgttggg cagtgtgttg attaatttcg taatgccgga
     8581 ttgttcaatg gctttccata ctacctgatc attctccttc tggttcacat ctccaaatcc
     8641 gacattatcc ttgaccgtca tttcatattg gacgaaatcc tgaaacacta ctcccatttt
     8701 ttcacggaag ctctctttat tcaaatcacg tatcgattga ccattaatca gaatgtcacc
     8761 ttcaaagtta gaatataatt gtgtgatcag cttaacgatt gtcgatttac cagaaccgtt
     8821 cttaccaacg atggctaatt tttcattccg atttagcata aagctaatat tcgagatggc
     8881 atttttattg gtattcggat atttgaagga tacgttgcga aattcaatgc tatgaatata
     8941 ggatatcctt tgctcaattt cctctacctc ctcttcttcc ggcatgtcca agaaatcaaa
     9001 gagctgtttt acatataggt tattttggca taggctcaaa attccctgaa caatattttg
     9061 tgacgtcgat tgggtaagat tgatggcctg aataaagctg attaaatacc ccaacatgat
     9121 ttgaccaata aatgcgcttc gaacagccag aaagataatg aatccgcagg cgatctgatt
     9181 aatgacctga aagattagtg aggtatacga cctgcgtgaa gccagcttct tgtcctcaag
     9241 atggaagcca ttgagtatcg ataaatatct ttcccgtagg taatttccca gttggaatat
     9301 tttgatttcc ttaaagctgt tgtcccgagt aacgagaaat gacagatacc aggattcccg
     9361 ctgctttcca gctctctgat agtacgtgtt aaattctctt tggccgatct tcaggaaaga
     9421 ataaaacgat aaacaaggga taaggataat cacaaaaata gcccaccact tccaagcgat
     9481 aagaatagcg gaagctgaaa ctaatgttac tacaccgcta atgatcccga gcatttggac
     9541 aaatatttca aagggcctgt agttagcttc tccttgcgca cgttgtagct tgttctgcac
     9601 atcggcatct tcaaaggact ggagcgtcat ctgatgagcc ttttcgatta attttaaatt
     9661 gactcgattt gatagaagac tttgaaacat ttttcgaaaa tacccgtcaa cgataccaat
     9721 gaagtctgat agaatgttca acaacatcaa caaaccaaag gctaagagaa ccggcctgaa
     9781 atctccatga ggcacgcttc ctaccacact attaatcaat tctcttgttg caagcaggac
     9841 aatcgcaggt aaaatccctt taaacagatt tgaaatcaat ataccaatta aataaccggc
     9901 atgcgtttcc cacagaagct tgaatatacg aggccagaag agaaatgtcc gaaaaatatt
     9961 tttggaagaa aacgacacat actcgtcttt catattggta tcaggagata acatgcagag
    10021 ctcctttcgc atgataaaaa tgagctgcgg tatatttggc taaagccata catttaatct
    10081 caagctctct gtcaacacct agcaaacggt tcaagtgcat atgcaccaaa ctggccagaa
    10141 tatcgtgtgg atgattcgtc aagcctttat gcttggcatt ctctatggat tcagcatacg
    10201 ttttgatcaa agctcgccgc tcatctagtg ctgcaattat gagatttgaa gcatccatct
    10261 tgtaaagcca tgcaggatta gaatctgctg cttcaattaa cgtctttttc aactctctgt
    10321 aggccttcat atgtttcttc ccgtcaactc tttcctccag ccatttcttc tgctcttcga
    10381 acgtcagtcc aaagccagcc aaaatatcca gtatatttgc tactgctatt acttccggaa
    10441 caaggttcaa tcgtttacgc cgaacctctc caagatatag acttacaagc ttactatctg
    10501 cagcaaatac accttctgca atctcgatca acccttcacc accgtatcgc tcgaattctg
    10561 gaacataagt gtcgatcgtc atggaaaccg cgagacctga attacgcaat cttttcatcc
    10621 attgactaat ttggccgatt cccgtagacc agagctcttt tgaatctcca ttaaacctta
    10681 atctgatatg gctttcctgg tctctatagc gcacgaagta gaatcttctg ctccaattat
    10741 taaattcagg ctgtttccac aaatcatcta aatgcaaccc tagcaattca gcctctcgct
    10801 cagaagtccc atataatttg atatagagcc agtcttcacc cggcagaaca cctcttgatg
    10861 caattggttg ataacccgag tcgtcaaata tcccacgctt tggaattgat tgaggcacgc
    10921 tcttggtatt taatacggga aatacaaatt caccagtata tgtttcccct ttcgaatgta
    10981 gaggcgaaca gcttggatga ttcatacatt ccgtaagaag cagctcctga ccattttgaa
    11041 gtttccccat ctcacgtctc aattcttcta tacataactg attatgtaaa tccaatagca
    11101 gtctgttatc ccccattgcc aaataaatat accgaggtac cttccatctc tccttccacg
    11161 agtaaaattt atcaagccat tctttacttc ccccggactg ctctaccccc atggtatgct
    11221 ttcccaatct ccactgagcc gagctgagta tgatgctctt atagcggagt cttggtaaaa
    11281 agggagactg ttctaccgga ccccagttaa aataggacca cgttttggta agttttctcg
    11341 ttatatcact gaggaaccta aagataggag gggaaattct gtggttgaac atatgagtct
    11401 ggagcggaat gatctccctt cccagcttct tggatttaat ataaaaacga tcataggttg
    11461 ctccaactag aagatcatca atatgaagtg tattcaactc attcttagaa gaattcgtac
    11521 cagaaacgat ttcatattcc gacagattct ttccaatcat aatatttgaa attctaccgc
    11581 tagagggcat aaacaccatc tccgctatgg ctgcctgagg atgcaatctc tgaacatgtg
    11641 aatgaatttg ttcgaagttc tgtataaacg atggatcgaa catatccaag aaacgcccga
    11701 atgttttccc tgctccgcta gacccagcac tcgcccccaa gactaacttg taatcgcctc
    11761 gatcgacctg ctcctgggaa tcagccacta gagaataata aatctccaaa gattctgggg
    11821 cattctgtgg atcatgattc agggtaagtt cttgaatatg ttcatccgtc agtacgcatt
    11881 cagcggaacc ctgcgcaatt gcctcggtta ccagctgaaa tagaatcgag ttgcgagtat
    11941 aggagacctg ttgggtttct gaagtgaaat ccggttgata agctttaggg atacctaaac
    12001 cccaatcgct atcaaaaagc tcgttgattg gaatttcctg atagacccca tatttctcga
    12061 gaaagcggtt taaatactca tttaattcat gcccttccgg gacatgcaat ttgcacatca
    12121 gctctgcacc caaaactaca tcgttagtga tggatcgtgg aagagtgaca tcttttttca
    12181 gcctcacatc aacctgaacc aaattactgg tctttacgac atcaaccatc ttctccgtaa
    12241 gttggcgata aataccctct ccgctaccaa tcttgctggt ttcatattgg agtaacaaag
    12301 cctgaacttc gctcaaagtt tccaaccact tatcagatcc tgatatgcca gacaaaacag
    12361 ttcctatatg ttctaacggt ggtacatcca tgagcggggg gcgaagctca cttattaaaa
    12421 attcctgttc taacagctga cgcaaataat tatgaatgat gtctaaattg gattccggga
    12481 atgcttctaa aattgctttc ttcaacgtct tcacgtcaat aggttctctt gctgcttgaa
    12541 gcgtcaaacc aactacctct gtcaatccaa tcgaattggc tccttcggga atagcttcaa
    12601 gatttaatat accgtattgt ggccgaaaag gtaatttgac tcgattccct ttgatcatca
    12661 acgttcgatt catacgaacc tttaattcat caaatataac cggatcagac tccattaatt
    12721 ttattaaatg aaacatccat tccatatcgg gcctcgccct tttttgattt tccgagaacg
    12781 aacacacctc caaatcgctc cggtctccga aatgtccttg gactaccctt gaaaagagac
    12841 caaaaggcgt tgttcgtgtc gacattcgaa taaaataacg caacaggcta atcagtgtct
    12901 tttcaacttt ttgagtggtt tttttgtcag cttcgtccgt tgggatattc aaaaattcat
    12961 agaaagatct tagagacgga gaggcaatgc tgatagcttc cttgactatg gatgtagagg
    13021 tctcttcttt taaacgcctg atcgtctcgg gcacagcctt ctcagattga aaattgtgtt
    13081 cagatatgac ttgtaaatag gtatccagtg gaagcagcgg ggttctcaca ataaaaaaat
    13141 cacatggctt aaaccatcgt tctgattgtt tttgttcttc atacatatta tgagttgcca
    13201 catcatttaa gctggactgt tctttcatca tgatgcacct ccaacatatt attcataata
    13261 ttcatacggt accctagtcc atggcaagtc actaaaatct tgggattact aggatcctcc
    13321 tctattttct ccctcagttt tcgaatatgg acatatactg tattcgacga agtaaatgta
    13381 tcaactcccc aaactttatt gataatatga tcaatatcta tcacccaatc acgggattcc
    13441 aggaaatatt caagcagcct gtattccatc aatgtaagca tgtgcccctc tccctgcttc
    13501 caaatcacct tacagcttcg gtcaaatata acattgggtg ataaataaat gacctcccgc
    13561 tccgcacttg ctttctttgc atcagtccgg gcggtaagag aaaataactg atttaaaatc
    13621 tcatattcaa gttgttcatt gcttcccggc gttaaaaata taaaaggaac ggcacttttc
    13681 tctcgaagtt tgtgccagat tgacagatcc ttcatcgtta tattattctg acacacaaaa
    13741 acccccatac atcgatgatc tgctatcgtt tcaatttgat taaaggaatc acaggataat
    13801 acttcaatgt tgctagaatg agtaatctgg tttaagaaca ccttaatggg actatcaggt
    13861 gacacagcca caattgtttt cttcatatat acccccctgt ctgtaatagt cctgctttac
    13921 tcaaggttat gacatgagaa atacctctct ccactttccc agatacatcg gatcatcccg
    13981 ttttccataa tcaagcaagc tcaaggcaat tccgacagcc ccttgcagta agcctggatt
    14041 gtcggtacaa accgtatctt cttgatctcg ataaccaaat gggctagatt catcaaacat
    14101 atacatcaat ctcgatgcca ctttctctgc aaataaggaa gcttcaggaa tgtcgcatag
    14161 cctatggaaa tggttagcca aatgcaataa accagtcagt ccatggcaaa acgaaggcgt
    14221 catgaaacca agctccctct ctccaagcct aaaggcggat cccgcagctt cggcagcaag
    14281 cttcttccaa tcttcattgc cgcactggac cccagcccgc cataatgtaa gcgagattcc
    14341 taaagtaccg tgacaccagc cttcgatttg tcttgcctct ttcttttcat tttgagctaa
    14401 accgctagta ttggaagata tcggccagaa tcgcccgtat tggtcctcac gagtttgctg
    14461 taccaaataa ttagcgatcc tatgaatcgt atgttgcaga ttctcaacct caacttgttt
    14521 atggtcagct gtaaccaata aggcaagaat cccggcaagc ccatgagcaa ggccgttttg
    14581 aacctgtcga tccgttccgt aaatggcaga atctattatg gtaaccgatt ccttgataat
    14641 attcgtcatt aaagggacgg caatttcgca cataccatca tcatacctgt atgtctccag
    14701 cacatatcta gcaacaccac ataaaccgct tactacatcg agtgaatcca agcccggaat
    14761 tgttctgcct gccttaaatt ggcttgctat atattgattt aactgagagc gtgtttttat
    14821 atagtttttg tggtcatccg aggccataaa tagtccatag gctactcctg ttactcccga
    14881 aaaaagcgaa atgtcaggaa tacaaagcgg catggctctg tataaggata ataaatgctg
    14941 atgaatggac tgcttccatc ctcgatccgg ttcaagtcga tcccattcag cgaataatac
    15001 ccatatgcca ggaataccat cagccaatga tatcggattc cagggcgctg ctcccctgga
    15061 aggagaatga ttttcaggac tcttcgtaat gttctctata tatgaaaggt caaccagtct
    15121 ttcagcaatg aatttactga tccttatcga ttgttcctgt aaacagcttg tcctcacatc
    15181 tcttccttct cccttcaaaa attaaaaaag tgagaaaaga cacggttgaa aataaccgtg
    15241 tctatcattc cctacatcat gctattatta acaagttctg caaaaagaca agctgatttt
    15301 gcaattcaat gttcctgtca ggcatgatgg agtacaaatt aagccgcttg caggttgcac
    15361 ttcatttgga gcaacctcat tttgagctac ttgcagatcc aaatcgaatt ggttattcat
    15421 catctcacct cctttattta acaatttaat atgataacta caaaacttaa aaaatcttta
    15481 tatttatctt aaatataact ttaataatga cctctcctcc acgatttatt aatgaataat
    15541 taaatcgatt ttaaggacag aatcttgaac cttctacgat aatttagata ggcaacaaaa
    15601 aggaggtacg cgcgtgaaaa aggatatgtt agatgtcaaa gagcaaaact caacatacat
    15661 atatgaaaag ggactagaga tcagcaaaga aattgcaatt cggttgagtg atcccaaatt
    15721 cgtgtttgat tctgttcata cgagagacaa tgtcatgacg gagactggac acttcccctg
    15781 gggggatatt tctttgtccc acggctaccc gggcaatatt cacttattaa cgcaatggcg
    15841 taggatcgat aaatctatga attggagcca ggcaatacat tcaaatatgg ttgagatcca
    15901 gtcatacctt tccagattcg gaacaggaga tatttcccta tatagcggtt gggcaggaat
    15961 tgcatctgct gtatacgctg cttcgaacca gggagaattt tataatcaat tcctgaatca
    16021 gatccatcga tggatgtcac ccctggttga gcaatggctg cgaactagca cggaaatact
    16081 gcagcaaaag aacggcgtcc ccgtggagct atacgatacg atatcaggtg cgagcggcgt
    16141 aggaagatac ttgttgaaga acgcagcgga tcctgttgtc gctccgttaa tagaaccgct
    16201 ccttcgcttt cttgttgaac ttacggaacc catctacata aacgataagt tagttccagg
    16261 atggtttaca cctagtaaat tccaatcctc tgctggtgat aagagcagtt ttccggtagg
    16321 cagcttcaat tgtggcatgg cacatgggat cccggggcct cttgccttac tatccatcgc
    16381 ttacaacaac ggaattgaag tcccagggca atacagggca atcgaaaata taaccgaatg
    16441 gttactggat tcgcaagaag aagacgaatt gggaagctat tggccgcata tcattccttt
    16501 tgaggagctc ataactaaaa ataagctgct tcgccaaaga gaagcctggt gctatggaac
    16561 acctggtgta acctgtgctt tatatatctc ctccataagc ctaaataatc cagccatagc
    16621 ccagactgcc ctcaaatctt ttataaatgc agtttcatac gaatgcgaca ggaatcgtat
    16681 ggattctcct tcgttatgtc atggtctgtc cggtcttctc cttatgagca agagaatgtg
    16741 gcactccacc aaagatccag caataacgat attaatcgat caacttatga ccaagctgct
    16801 tcaacgattc gactccagca ctcctcttgg atataaggat gcggaaccag gagtagcaaa
    16861 tacgattcga tggcttacaa aagccgggct gcttgaagga gttgcaggaa ttgctgctac
    16921 actccaaggt actggagagg cagatcaaaa tgattgggat tatatgctta tgctttcata
    16981 atcacccctt tcttttgggg tttttagaat aaaaagggtt aaattcctat attataaata
    17041 atcctaactg tttaaagtta ataataggta aacggaagtt gaacaacgag taaactaaat
    17101 atggattgtc tgctctaatt tttcgaaaac gtaaaaagga gtcttcatct gcgaagactc
    17161 ctttcttgat tgtgctaaat attttgctct aagtaagtca ccataaaagc gagctacacc
    17221 agcgccttca gcgcaatatc cgtccggttc tgcttgcctt caaacaaaat cgcttctgca
    17281 cgctcatacg ctttcgcccg tgcggatgcg atatctgccc ctaatccaac aacgccgaga
    17341 acgcgtcctc cattcgttct ccacgttccg tcagcatcgc gagaggtgcc cgcatgaaat
    17401 acaatcgttc cgtcctgctc gttatccagc ccactgatcg ctatcccttt cggatacgat
    17461 gcaggatacc cgccggaagc caggatgacg cataccgctg cctcgtcact ccactccagt
    17521 tctaaatcag ccaggtttcc gttaacggca gcaaggaata cctcaagcag atccgtcttc
    17581 aagcgcggca atacgacctg cgtttccgga tcgccaaatc tggcgttgaa ctcaatggtc
    17641 ttcggttttc cgtccggcgt aatcatcaat ccggcgaaca gaacgccccg gaacggacga
    17701 ccttccgcta ccatcgcttt cgctgtgggc ttgataatcg tctcaatggc ctcttcaatg
    17761 acagatgact gaatatgagg caatggagaa tacgttccca tcccacctgt attcggtccc
    17821 aaatctccat cataagccgg tttatgatcc tgtgccgccg acatcggctt cacggtttca
    17881 ccatccacaa aggcgaggat cgacatttcc tggccttcca ggaactcctc gatgaccacc
    17941 cggcttcccg catcgccaaa caccttcgat tgcataatgt cgctgagcgc ctgctcggct
    18001 tcctcgatcg tccgcgcaac ggtaacaccc ttgccggctg cgagcccgtc cgctttcacg
    18061 acgatcggtg cgccttgctg gcgcaagtaa gctagcgcct tctcgtaatc gtcgaacttc
    18121 gcgtaggctg ccgtcggaat gccgtattta tggagcaagt ccttcataaa agttttgctg
    18181 ccctcaattt cggctgcatt tttgcgcgga ccgaataccg ggatgcctgt agcgtcgaat
    18241 gcatctacga tgccgtcagc cagcggatca tccggaccga caacaatgag tcccacctgc
    18301 ttctctacgg cgaatgccgc cagcttctca aactccgata ccgcgatcgg cacgcactcg
    18361 gccagctgtc cgataccggc gttgccgggt gcgcagtaaa tcttatccgc tttcgggctc
    18421 tttgccagtg cccatacgat ggcatgctct cttccgccgc ctccgataac caaaatatcc
    18481 atggtttacc cctcccgatt catttcaact ttaccgtcaa catttcataa catgaatgat
    18541 ttacagggcg aagcgtgaga tcatcttcac cttctggtcc ccttaaactt aaaggcggcg
    18601 cgctcgaaag agcggcgtcg cctctatatg ttgctgattg aaaggtgatc ttcagctgca
    18661 gcctcatggt tgcagcgaag ccccttttta tgctcatgaa ttagtgttta aaatgccgca
    18721 cgccagtaaa gaccatggcg atcccgtatt cgttggctgc cttgatggat tcctcatcct
    18781 taatggagcc gcccggctga atgatggcgg taatgccggc tttcgctgca agctcaacgg
    18841 tatctcccat cgggaagaac gcatcggaag cgagtacggc tcccttggct ttctctcctg
    18901 cctgttccac cgcaatacgc gccgagccga cacggttcat ttggcctgcg ccaacgccaa
    18961 cggtcatgtt gtctgcagcc aatacgatcg cattagattt cacgtgcttg accactttcc
    19021 agccgaagag cagctgcttc agctcttctt ccgttggttt ccggtccgtc gcaactttca
    19081 gatcagcggc gtccagggaa tgcacatcgc tttcctgtac gatcatgccg ccttcgatgg
    19141 ttgtcaccgc aagtgtgctt tggcgctcct tggccgaacc gaactcgccc atcttcagta
    19201 gacggatatt tttctttttc gtgataatct ccagcgcctc cggtgtgaaa tccggtgcca
    19261 ggataatttc aaggaaaata tccttcagca gatccgccgt cggagcgtca attgtccggt
    19321 tcgccgccac gatgccgccg aagatggatg tcggatcagc gttgtaagct ttttggtaag
    19381 cttccagcac atttgtcccg atgcccacgc cgcaagggtt catatgcttc acggccacca
    19441 cggttggctc gtcgaattcc ttcacgatct gcagggctgc gttcgcgtca ttgatattgt
    19501 tataggagag ctctttgccg tgcagctgct ccgcggtcgt caaagtaccc gctggtgcca
    19561 gcggtttacg gtaaaatgcc gctttttgat gcggattctc gccgtaacga aggtcctgaa
    19621 ttttctcgta ggtgacgcta aagcgctcag gaagcggatc gcccgttaca ttcgacaaat
    19681 agtcagaaat caacgtatcg taggccgccg tatgacggaa aaccttggct gcaagacgtt
    19741 tgcgggtttc cagcgtcgtg tcgccgccgt cacggatttc ctcgatcacg ctgccataat
    19801 ccgccgcatc gacaaccacg ctcacaaaag catggttttt cgcagccgaa cgcagcatcg
    19861 tcggcccgcc aatgtcgata ttttcgattg catcctcata ctcgacaccc ggcttcgcga
    19921 tcgtttcctg gaatgggtac aggttcacca cgaccagatc gatgtaatcg aggcccagct
    19981 cctgcatctg acgctgatgc tcctcgctgt cgcgaatggc aagcagaccg ctgtgcacgg
    20041 ctggatgaag ggttttgacg cgtccgtcca gaatctcagg gaatccggtc acatcggaga
    20101 tgccgatgac aggaactcct tccttggcga ggaggttctt cgttccccct gtcgaaatga
    20161 tctctacacc caatgaagac aactcgcggc aaaactccac gatgccggtt ttatccgaaa
    20221 cgctgaccaa agctcttttg atacccacgt tcataccccc tattatgaat aaaattaact
    20281 aagtaagcct gtcttgattc cgtagatgct gtcgaagatc cataattgca aattatttcc
    20341 cgagaaatat cgaacatgtc gattcaccga aagaccttgt ccgcttttat tacaaaagcc
    20401 tattcggtaa tcgtcacatt ccgcccgttc agcgaaattc gcccctgggc gaaccaggaa
    20461 acgacttcag agtataactt ctgctccacg gcatgaatgc gttctgccag cacttctgcc
    20521 gtttcgcctt ccttgatctc tacggctttt tgagcaataa caggtccggt atccatgccg
    20581 ccatccacaa aatgaaccgt gacaccagtc atcttcacac catagtccag cgcttggcca
    20641 atcgcgtctt ttcctggaaa agcaggcagc agcgatggat gaatgttgat gatccggccg
    20701 ctatagaact cgacaaagga cggactcaat aaccgcatat atcctgcaag aacaatcaat
    20761 tcgacaccgc gctgctgaag ctctaccgca atttcacgtt cgtaatcttc cttcgaggca
    20821 taatccttcg gctgaaaggc gaatacatcc acattcgccg cttgagccag ctccacgacg
    20881 ggagcctgtg gcttatcgca taccaggatg ctgatcacgc cgcccagggc ccccctgtgc
    20941 tgcgtatcta ccaaagcctg aaagttactg cccctgccgg aagcgaaaac cgcaatccga
    21001 aacggcctca ttacacctca gctcccgtaa aggttacgat gcgctcgcct tcggtgaccc
    21061 ggccgatcac ataagcctct tcgcctgcgg agcggaggta ttgaagcact ccgtctgcat
    21121 cctgttcttt gacgacaagc accatgccga ttcccatatt aaatgtcgta aacatatcct
    21181 tgttcgaaat gctgcctttt tcctgcatta gcttaaagat cggcagaatc ggccaagagc
    21241 cgtattcgat gtcgacattg acgccatccg gcagcatacg cggaatattc tcgatgaatc
    21301 cgccgcccgt gatatgcgcc atacccttta cttcgatctc tttcaacagt ccgagcagcg
    21361 gcttcacata aatcttggtc ggagcgagca gtacgtcgcc aagacgtccg cccagttccg
    21421 gaagctcttg ctgcagggag tagcctgcgt cctccagaag cagcttgcga acaagcgaga
    21481 agccgttact gtgcacaccg ctggatgcta gaccaatcac cgcgtcgcct gccgcgatat
    21541 tcgacccgtt gatcattttg cttttgtcga caatgcctac ggtgaagccc gcgatgtcat
    21601 actcgccttc actgtacatg cccggcatct ctgccgtttc cccgccgatc agggaacatc
    21661 ccgcttggtt gcatccgtcg gcgatccctt tgacaatgga ttcgattttg gacggaatga
    21721 ccttatcaca agctaaatag tcgagaaaaa agagcggttc tgcgccttgc accacaatat
    21781 cgttcacgca catcgctacc gcatcaatgc cgatggtatc atgttggtcc atcgcgaatg
    21841 cgagcttcag ctttgtgccg acgccatccg tgcctgagac gagtaccggc tcttcatatt
    21901 ggtctttatt cagcttgaac agtgcgccaa aacccccgag gtcggtcatg acttccggtc
    21961 tgaaagtcgt tttgacatgc tttttcatac gctctaccgc ttcattgcct gcagcgatat
    22021 ccacgcctgc ttgtttgtaa gtatccgaca cgcgctcaac actccttttt tgttatgacg
    22081 aaagtatctg ttcacacatc atttatgggc ttaatcaata accagcttaa agaggttgtt
    22141 caaaccaacc ttctcggtgc tgaaaaccga cctttttgaa cacgcattta atgggtgtat
    22201 ccgagaaaaa atggctgtcc actgcagaat cagcagctgc agcccatctt ctcttccccg
    22261 ttaaaatcaa tctgcgtcgg gtaatcatta tcaaagcatg ccatgcacaa gccgccttta
    22321 gggctgtgct catcataacc gccaatggcg gatataagtc cctccgggct caggaacgat
    22381 aaggaatccg cgttgatctc ccggcagatt tcctcgacgc ttttctcgga agcgatgagc
    22441 tctctgcggt ccggcgtatc gatgccgtag aagcaagggt tcttgaatgg cggcgacgta
    22501 atccgcacat gcacttcggt cgcgcccgct tcgcgaagca aattaacgat ccggcgggac
    22561 gtggttccac gtacgatgga gtcatcgatc atgaccaccc gtttgccttc gaccacgcgc
    22621 cgtaccgcgc tcagcttcat cttcacgccc tgttcgcgca gctcctggct cggctgaatg
    22681 aacgtccggc ccgtatattt attcttgatc aatcccagct cgtaaggaat gcccgtttgc
    22741 tcggcataac cgatagcggc cgagatgctg gaatccggta cgcctgtaac cacatcggca
    22801 tccacgaacg attccagggc catcttgctg cccatccgtt tacgggccga atgcagattg
    22861 gagccgttca gatcgctgtc cggacgggag aaataaatat attccatcgc gcacaacgct
    22921 ttgcgtcccg cttccgtata ccgttcttcc cgaagcccgt tccgatcgag aatcagcagc
    22981 tctccgggag caacatcgcg gatcgcttcc gccccgatga cttcaagcgc gcaggtctcc
    23041 gaagtgaaga tatacgcatc gcccagacga cccatcgtga gcggacggag tccgttcggg
    23101 tccgaggcga cgagcagctt gtcattggtc atgagcagaa aggcgaaccc gcccaccaag
    23161 cgctgcaagg catccttggc agcctcgaca aaatccttcg gcgaacgcgc gatcagatgc
    23221 gcaatgactt ccgtatcgct ggtcgtctgg aatatggagc cctccatctc cagctcgcgc
    23281 cgaagcttcg gctcgttgac gatgttgccg ttcgtagcaa tcgccagatt gccctcgcga
    23341 tatttaaaga cgagcggctg cgcattcgtc agtctgctgt ccccgctggt cgagtaacgg
    23401 acatgcccga tcgacatgct gccctgcagc gattccagct tgtctttatc aaacacttct
    23461 tttacaagtc ccatcccgcg gtgataattg aaattctcgc cgtcggctac gcagattcct
    23521 gcgctttctt cgccgcggtg ctggagggcg tgaagcccgt aataggaaag ggaggcggca
    23581 tcgggatgcc caaacacccc gaatacgccg cactcttctt ttaatgtatc aaaaatatcg
    23641 ctctgacctg ttccctcatt gtagtaatcc cctgtccaca gtccttcggg tatcagttca
    23701 tgagacatgg aatggcatcc tcccagacgg atttcaaagc ctccacggat tcttccagcg
    23761 cagaagcacc gttaatgtta atgctaagct tattcccgcc gactacgcca agcgcggtaa
    23821 atggaacgcc cgcttcttgc aggagcttct ccagcgcgtt cttatgatca ggagacaccg
    23881 acagcacgat ccgggattgg ctctcgctaa agagcgctac gtcgttacgc agatcggttg
    23941 accattgcac gctcgcccca acgttgccgc tgatgcagct ctccgccagc gcggctgcaa
    24001 gtcccccttc cgacacgtca tgcgcggatt gtaccagacc ggattggatg gccttcagta
    24061 cgccgccgag caatttcttc tcggtatcca ggttcagttc cggtggtctg ccttccgata
    24121 ctccatgcat gatcgcttgg aactcgctgc cgcccagttc cgcacgggta tcacccagaa
    24181 cgtagatggc atcgccttcc gccttgaagc cttgtgtcgt aatatgatcc gtatcatgga
    24241 tcaggccgac catgccgaca accggcgtcg gataaatcgc gcctttggca ttctcgttgt
    24301 agagactcac atttccgccg atgaccggcg tttcaagctc acgacaagct tccgccatgc
    24361 cgtccacggc tttttccatc tgccagaaaa tttccggctt ctccgggctt ccgaagttca
    24421 ggttatccgt aatcgccagc ggctcggcgc cggagcacac gatattgcgc gctgcttcgc
    24481 tgaccgcgat tctgccgcca agctcagggt cgaggtagac gtaacgtccg ttacaatccg
    24541 ttgtcatcgc cagggctttg cgcgttcccg gcaccgttac gacagcagca tccgaacccg
    24601 gacgaacggc cgtgctggtg cgaaccatat aatcgtattg gttgtatacc catgctttgc
    24661 ttgcaaggct tggcgaaccg agcaccttct tgagggcacc gcccaaatcc ttcacttctt
    24721 cataacgaag catatccacc gcagcctgct cttggtaata agccggttct tgggatggtt
    24781 tgttgtagat cgggcattcg tctacgagcg ctttaaccgg catgtcgcct accacctcac
    24841 cgtggtggat cagcttcagg cggccatcgt ccgtcacttt gccgactttg gcgcagataa
    24901 cgccccagcg ttcgaagatt tctcgggctt gctcctcatg cttcggctca accacgaaca
    24961 gcatccgttc ctgggactcc gacagcatca tttcataagg cgtcatgcct tcttcgcgct
    25021 gaggcacttg gtccaggtac agctcaagac cgttgcctgc tttacttgcc atttccgcgc
    25081 tggagcaagt caatccagcc gcgcccatat cctgaatgcc cagcacaatg ccggaatcaa
    25141 tcagctcgag gcaggactcc atcacgagtt tctccatgaa cggatcgccg acctgaacgg
    25201 ccgtgcggtt cgcttcggat tcctccgtca gctcaacgga agcgaaggtt gcgccgtgga
    25261 tgccatcgcg gccagttgga ggcccgacat aaaagaccgg attgcctacc ccttttgcaa
    25321 cgccgcgctg aatcttatca tggtcgataa cgccgacgca catcgcattg accagaggat
    25381 tgccttcata actttcgtcg aatacaacct cgccgcctac cgtcgggatc ccgatgcagt
    25441 tgccgtaacc ggcaatgccg gataccacgt gctcaaacaa atatttaacg cgatcgctct
    25501 ccagcttgcc gaaacgaagc gagttaagaa tcgctaccgg tcttgccccc atggagaaaa
    25561 tatcgcggat aatgccgcca acgcccgtgg ctgcgccttg ataaggctct acagcggacg
    25621 gatggttatg gctttcgatt ttgaatacaa ccgcttggtt gtcgccgata tcaacgatcc
    25681 cggcgccctc gcccggtccc attaggacgc gcgggccgct tgtcgggaaa cgacgaagca
    25741 gcggcttgga atttttgtag gcgcaatgct cggaccacat gacactgaat acgccgattt
    25801 ccgtgtaatt cggcttgcgt cccatgaagg aacagatcag ctcatactcg ctgtccgaaa
    25861 ctcccatttg cttgtaaatc tgatgctctg cgatctgttc tgctgtcggt tccttaacgg
    25921 acgtttgctg cgccatgagt atccctccat gcctgtaata tggatgtaaa cattgcttta
    25981 ccgtcatccg agccgagcag gctgctgacc gcgcgctccg gatgcggcat catgccgatt
    26041 acgttgcccc gctcattgca gatgcctgcg atatcctcga tcgagccgtt cggattgttt
    26101 tgatacgtaa atacgatttg ccggttgtcc cggagctttt gaagtgtttc ttcatcacag
    26161 taatagttgc cctcgccatg cgcgatcgga atgacaatct cttgcccctc cgcgtaatct
    26221 cgcgtaaacg gcgttgtatt attgttcact ttgagcaccg tgtcatgaca gcggaatttc
    26281 atcgaatcgt tgcggcgcag agctccggga aggagtccgg cttccgtcaa aatctgaaat
    26341 ccgttgcaga tgccaagaat atacttgccc tcttccgccg ccttcgccac ttcgctcata
    26401 accggggcga atcgggaaat cgcaccacac cggagataat ctccataaga gaatccgccg
    26461 ggtaccaaaa tgcaatcata tggagaaagg tccgtagccg tatgccacac ataatccacc
    26521 ggctgaccaa tcgtctcttc taccgcctta taacagtcaa tatcacaatt ggaaccagga
    26581 aagaccagca ctgcaaatct cattggttta gccctccaat tcataacggt agttctcaac
    26641 caccgtattg gccaaaagct tctcgcacat ttcttttact cgcagctcgg cttcctcacg
    26701 gttgtccgta cccagctcaa gttccatata tttaccgatc cgcaggcttt ccacttcctt
    26761 gtaccctatc gaatgaagtg caccttgcac cgctacccct tgagggtcca atacgctctg
    26821 cttaatcgtg acgtaaacct ttgctttcaa cattgtatcc tgttcctcct cggtatatat
    26881 gaatgaaatg gtttataaaa gctttacagg cttgcacccg tgattcgact gtaaatatcg
    26941 gtatagcggc gcgtcgtctc ctctaccacg gcctgtggca g
//
