LOCUS       NZ_JAIFIS010000001     20240 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Paenibacillus lautus strain PLV Scaffold_1, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIFIS010000001
VERSION     NZ_JAIFIS010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus lautus
  ORGANISM  Paenibacillus lautus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Endophytic bacteria from Leucojum aestivum L. in vitro plants, a new
            source and elicitor of Amaryllidaceae alkaloids biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-2021) Center for Experimental and Innovative
            Medicine, University of Agriculture in Krakow, Mickiewicza 21,
            Krakow 31-120, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly         :: GCA_003590055.1
            Genome Coverage                   :: 496.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019641495.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 05:30:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,260
            CDSs (total)                      :: 7,166
            Genes (coding)                    :: 7,057
            CDSs (with protein)               :: 7,057
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 2, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 109
            CDSs (without protein)            :: 109
            Pseudo Genes (ambiguous residues) :: 0 of 109
            Pseudo Genes (frameshifted)       :: 38 of 109
            Pseudo Genes (incomplete)         :: 74 of 109
            Pseudo Genes (internal stop)      :: 16 of 109
            Pseudo Genes (multiple problems)  :: 16 of 109
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:25:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5117419
            Orig. end                         :: 5137659
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIFIS010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20240
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="proteusin"
                     /region_number="10"
                     /rules="(PoyD or TIGR03793)"
                     /tool="antismash"
     cand_cluster    1..20240
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PoyD or TIGR03793)"
                     /kind="single"
                     /product="proteusin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20240
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10240](+)"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10240
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PoyD or TIGR03793)"
                     /neighbourhood="10000"
                     /product="proteusin"
                     /protocluster_number="1"
     regulatory      116..147
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF00522"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00522"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    186..195
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            282..953
                     /gene="queC"
                     /locus_tag="K1X09_RS23790"
                     /old_locus_tag="K1X09_23695"
     CDS             282..953
                     /EC_number="6.3.4.20"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017690199.1"
                     /locus_tag="K1X09_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23695"
                     /product="7-cyano-7-deazaguanine synthase QueC"
                     /protein_id="WP_194541411.1"
                     /sec_met_domain="QueC (E-value: 5e-84, bitscore: 279.6,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNEKAVVVFSGGQDSTTCLFWAKERFAEVETVTFDYGQRHKLE
                     IECAAQIAKEQGVKQTVLDMSLLNQLAPNALTRSDIEIAEGDGLPTTFVEGRNLLFLSF
                     AAVLAKGIGAKHLITGVCETDFSGYPDCRDSFIKSLNVTLNLAMDYPFVIHTPLMWLDK
                     SETWELADQMNALEYIRDHTLTCYNGIKGDGCGECPACKLRKAGLDNYMQRRNHVSEGG
                     V"
     gene            955..1446
                     /gene="queD"
                     /locus_tag="K1X09_RS23795"
                     /old_locus_tag="K1X09_23700"
     CDS             955..1446
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTPS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591644.1"
                     /locus_tag="K1X09_RS23795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23700"
                     /product="6-carboxytetrahydropterin synthase QueD"
                     /protein_id="WP_220686200.1"
                     /sec_met_domain="PTPS (E-value: 3.3e-35, bitscore: 119.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSREPGAFRIVEHLQKLGEDIDAGNLRYHRKRVLVSKEFTFDAAH
                     HLHCYEGKCKNLHGHTYKVVFGISGTPNEVGITVDFGDIKDCWKTDIEPYLDHRYLNET
                     LPPMNTTAENMVVWLFEKMEESLRSRESHEQQGTRTEFVRLFETPTSYAEVRREWMIDE
                     "
     gene            1439..2230
                     /gene="queE"
                     /locus_tag="K1X09_RS23800"
                     /old_locus_tag="K1X09_23705"
     CDS             1439..2230
                     /EC_number="4.3.99.3"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="queE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429145.1"
                     /locus_tag="K1X09_RS23800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23705"
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_194541410.1"
                     /sec_met_domain="QueE (E-value: 6.3e-55, bitscore: 184.8,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.8e-11, bitscore: 41.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.7e-12, bitscore: 46.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVHVKPENDSTASSPVIAVDRPIPVMEIFGPTVQGEGMVVGRK
                     TMFVRTAGCDYRCSWCDSAFTWDGSAKDTISRMNADEIWQELYRLGGERFDHVTLSGGN
                     PALLSQLGTLVDELHRHGITVAVETQGSRWQDWLNDIDEVTISPKPPSSGMNTDWGKLD
                     DIVSKLSARAPGRSFSLKVVVFDDKDLSYAETVHERYPNVPFYLQTGNPDVGTGDTTSL
                     VSHLLDRYELLVDAVMQSDRLNDVRVLPQLHTLVWGNKRGV"
     misc_feature    complement(2233..2246)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.74"
                     /tool="antismash"
     gene            2298..2795
                     /gene="queF"
                     /locus_tag="K1X09_RS23805"
                     /old_locus_tag="K1X09_23710"
     CDS             2298..2795
                     /EC_number="1.7.1.13"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0033739 - preQ1 synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046857 - oxidoreductase activity, acting
                     on other nitrogenous compounds as donors, with NAD or NADP
                     as acceptor [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009334932.1"
                     /locus_tag="K1X09_RS23805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23710"
                     /product="preQ(1) synthase"
                     /protein_id="WP_009591586.1"
                     /transl_table=11
                     /translation="MAGRQKEEMEDVTLLGNQGTKYTFEYDPGILESFDNKHPYRDYFV
                     KFNCPEFTSLCPITGQPDFATIYISYIPDIKMVESKSLKLYLFSFRNHGDFHEDCVNII
                     MNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEEIAANRLMNHDLYPEKVD
                     NR"
     gene            complement(2917..3822)
                     /locus_tag="K1X09_RS23810"
                     /old_locus_tag="K1X09_23715"
     CDS             complement(2917..3822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733924.1"
                     /locus_tag="K1X09_RS23810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23715"
                     /product="EcsC family protein"
                     /protein_id="WP_220686201.1"
                     /transl_table=11
                     /translation="MTEMESRQQLESQLQEILKWEKEQKDVMFWEKLGRIPFMLLDRLT
                     PKAVQEKIGNALNEVGGFIQSGGKHLVREKAVMNVLAQAAGLDGPNAVSGPSVKSAQEE
                     SIEDENEEGVASTSGLTLASAAKLPLQVMDTAADTLTVKRVKFAAAQGAATGIGGIFTI
                     AADLPMVLGQSLKVLQEMALCYGYDPNDPRERVFIVKCLQFASADIVGKKAVLEELATF
                     DDEQMTEQVFSQLQGWREVVQSYTDNFGMKKLFQLIPIAGIVFGSISNKGTISDVAEAG
                     KMLYKKRRLNYRLKKMEYPL"
     misc_feature    3851..3869
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.19"
                     /tool="antismash"
     gene            complement(4008..4481)
                     /locus_tag="K1X09_RS23815"
                     /old_locus_tag="K1X09_23720"
     CDS             complement(4008..4481)
                     /GO_function="GO:0008199 - ferric iron binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591755.1"
                     /locus_tag="K1X09_RS23815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23720"
                     /product="Dps family protein"
                     /protein_id="WP_220686202.1"
                     /transl_table=11
                     /translation="MSNFTQQTQGTTTNELQQILNTQVANWSLLGVKLHHYHWYVKGPQ
                     FYMLHEKFEELYNTAAGYVDELAERMLAIGGKPAASMAQYLNLATLKEVSDENTAEQMV
                     GRLVADFEQLAGELKAGIEAADQEGDDATSDLLTGMVSDVQKHTWMLNAFLGK"
     gene            complement(4687..6135)
                     /locus_tag="K1X09_RS23820"
                     /old_locus_tag="K1X09_23725"
     CDS             complement(4687..6135)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014281589.1"
                     /locus_tag="K1X09_RS23820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23725"
                     /product="potassium/proton antiporter"
                     /protein_id="WP_194541406.1"
                     /transl_table=11
                     /translation="MSLPSFVDSMILLCGALLVTGVLTTKFSSRFGMPALVLFIAIGMI
                     LSRFIYYDNAELTQLVGIFALIVILFQGGMQTDFKEIKPVMGTAISLATIGVLLTTVVV
                     GICAAFILDISLQEGLLIGAIVGSTDAAAVFSVLGGTNLKKRIRMTLEAESGSNDPMAV
                     FLTVSLIEWIEYPELNLIGLIFSFVMEMGLGLVVGVLIGMLAVYVINRINFDSSGLYPV
                     TALGFAVMSYAAAAWLGASGLLAVYVMALLLGNTELTYRKTIQAFNQGFAWMMQIVMFV
                     LLGLLVFPNELSEVVWQGLLLSLILIFIARPIGVFSSLLFTKFAMREKILISWAGLRGA
                     VPIVLATYPVLAGIKHGELFFNVVFFVVLTSAVIQGTTISPLTQMLSLVEKDKAKAPTL
                     LELMALGKTDSEINHILVDGEMPIIGKEIQQLNLPDDILFTAIIREKRIITPKGSTVIE
                     AGDTLYVMNPKQKRKEMKTILGLS"
     misc_feature    6250..6261
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.16"
                     /tool="antismash"
     gene            6329..7438
                     /locus_tag="K1X09_RS23825"
                     /old_locus_tag="K1X09_23730"
     CDS             6329..7438
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591747.1"
                     /locus_tag="K1X09_RS23825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23730"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_220686203.1"
                     /transl_table=11
                     /translation="MNISIMKSDQLHQAVELSDRIFLKQPEQPSMGVSFPPIFSPGISH
                     SYGAWDQDKLVSFMGFVPFTIQTRGARLNVYSIGSVCTDPEYRGQRLAGSLLEQCIRHG
                     EATGASLILISGGRSLYTRAGSRLFGRALRFRLDRAVMEPLRAVTGKQVRIRAMQPQDV
                     FHLQKLMEQREAGYVTTASELNNLLGASAYSNVIRLEQQVLVAEENGVLTAFAIIAVPG
                     AVMTPSRESTLVEWGGSPEAAALVIAEAISSFNLSELTVPLPWQDKELAALIQSAGIKP
                     EYIQNEGTVYLVSGPELLRQLAPLLPEGLIQADGEHGPYRLALNNEVLELDDEGLLSIL
                     FDPESSYRANGSITFEPIPLPYTAGLQYI"
     gene            complement(7632..8000)
                     /locus_tag="K1X09_RS23830"
                     /old_locus_tag="K1X09_23735"
     CDS             complement(7632..8000)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1X09_RS23830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1X09_23735"
                     /product="hypothetical protein"
                     /protein_id="WP_220686204.1"
                     /transl_table=11
                     /translation="MFTAYCAVSVLPSARNRDRRQDRVRVWDHQDRLDATDPVRVPVRQ
                     DAMGHVHARVQEIRVQEIRDRDIPDKTEGKDRSDNKVDSMDKDRTGIRGKALEYPGLFG
                     IAGLFLDDDSSHAPLSIR"
     misc_feature    8049..8064
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.3"
                     /tool="antismash"
     gene            complement(8077..8739)
                     /locus_tag="K1X09_RS23835"
                     /old_locus_tag="K1X09_23740"
     CDS             complement(8077..8739)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591703.1"
                     /locus_tag="K1X09_RS23835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23740"
                     /product="general stress protein"
                     /protein_id="WP_194541403.1"
                     /transl_table=11
                     /translation="MTQKIVGAFRTEQEATRAIEELKQQGFRADEISVIAKDRGESSHI
                     QEETGTKAPEGLASGAATGGVLGGVTGLLAGLGALAIPGIGPIVAAGPIAATLTGAAVG
                     AGAGGLVGGLIGLGIPEEQAEEYGGYVDEGHILVMVDADETNGGRVYDIFRSNSALNEH
                     HYREEGTYSGSGAPVDSRSEAAAATEDAVPDPNLYQGYGDGNGGAISPDRDEISKRR"
     gene            complement(8784..8918)
                     /locus_tag="K1X09_RS36365"
     CDS             complement(8784..8918)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1X09_RS36365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_259445416.1"
                     /transl_table=11
                     /translation="MNIYKVKYYQSLKLDNYGVIGAAGRPITDTTSVFLFDYGGWRLS"
     gene            8975..9928
                     /locus_tag="K1X09_RS23840"
                     /old_locus_tag="K1X09_23745"
     CDS             8975..9928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733919.1"
                     /locus_tag="K1X09_RS23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23745"
                     /product="hypothetical protein"
                     /protein_id="WP_194541402.1"
                     /transl_table=11
                     /translation="MNWFKPFEDDLAAAFSVCEARLSELPAPLNEIGLSYLRKFDVFEQ
                     DSSKNYICYLLPFWMKELTELPADVYRHLSAANIIGMLYYFIQDDIMDSPHDSQSSTDS
                     KHHLALANLLYYEFLTSYQPYFPANSDFWSYFKNYTFEWSEGVIHETQDDYFKHNPIMV
                     AKKAAPVKLGSTAALLLSDQAGLIPRTNDVMNHVLLTLQMMDDWTDWKQDLADGSYNCL
                     LSLIKSELGRPRDTNLTMAEVQEAIYINNALKPYADIAAATHAFLLSVDIDAPHLISFH
                     QTMVDELQAEANHIENSKETLSFGGLNYYLSILSKK"
     gene            10001..10240
                     /locus_tag="K1X09_RS23845"
                     /old_locus_tag="K1X09_23750"
     CDS             10001..10240
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     proteusin: TIGR03793"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007130823.1"
                     /locus_tag="K1X09_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23750"
                     /product="NHLP leader peptide family RiPP precursor"
                     /protein_id="WP_194541401.1"
                     /sec_met_domain="TIGR03793 (E-value: 2.1e-20, bitscore:
                     70.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEAIFQTQLIQKAWEDPSFKAKLLSDPKSAIKEVLGVRIPDHI
                     EIRTLEENPNELYLVIPPNPSGVIKSEATAKAIW"
     gene            complement(10335..12224)
                     /locus_tag="K1X09_RS23850"
                     /old_locus_tag="K1X09_23755"
     CDS             complement(10335..12224)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733917.1"
                     /locus_tag="K1X09_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23755"
                     /product="sensor histidine kinase"
                     /protein_id="WP_194541400.1"
                     /transl_table=11
                     /translation="MKSGWRIAVFLIIVFTLSQGLPRLVFATEETAVRAAIKEWRILWS
                     ESRGIPESVPVHINDWMETSAGDSKPFKPHTKASAWIHMKIPEIASTSPGILIDKLHGQ
                     QVAVYANHEKIYESTRTYNYELNYILLPLHQNMLGKDLHIWLETARDHVTIEGKILVGD
                     YQDMFNRFIKSNLMDIILGSAFIFIALVMLICAIFLNRKYLVAVLSLSCIILSVGILVF
                     TYSPFLYTIFNQYGNIYTHLYDISLFILLPSFSLFFETIFGPGWKGLLRKLRKFQIFYS
                     LFCGLFLIVNQWGSNQWFDLYYFFSVHVMGIVMIVQFVLLVGSSMYYAVKGNKDAVIFN
                     AGFAIFAVVGLSELLQFFLTRGSYNLFLWKWGIVSFIIALIVILGRHFAKNHERILQYS
                     KELEMFNNELQRSEKMEIISELAASVAHEVRNPLQVTRGFLQLLTGKAQATEREYLDLA
                     LVELDRASGIITDFLTFAKPEFGKDTVLRVAEEFKHIEGILGPLAHLQGGRITVDIPED
                     ITIRGNSSKFKQAFINIVKNSIEALGEEGLVHIRCYRQQDQVFIHVIDNGEGMEPDVLA
                     RLGEPYFSNKTKGTGLGLMVTFRIIEAMNGDIYFTSKKGVGTDAVITLPAAGE"
     gene            complement(12374..14290)
                     /locus_tag="K1X09_RS23855"
                     /old_locus_tag="K1X09_23760"
     CDS             complement(12374..14290)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733916.1"
                     /locus_tag="K1X09_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23760"
                     /product="sensor histidine kinase"
                     /protein_id="WP_220686205.1"
                     /transl_table=11
                     /translation="MKDMPKSIFLLLLVVPLLLIISTISPGKSDAKSSQIVISDWQFMW
                     DNEQQEVVSPVNLQGRSWLTGIPDKKGPPESDGVYSAWNRFTLPALPWKHSAIMIDRIK
                     GQDVVAFLENEQVYEAKRDYMYTNHSLLLPVHPDDAGKTVYIWTNGVKDMTLGIEGDII
                     LGEYEHLRGSFIKKDLEDFILGSSFLFIAVVMFFCCLFLPKHTVSSWLSLSVVILASGA
                     MLITYSPFLYTFYGEQGSVWVSVFDISLFAVLPALYYYFENMYGPGPYRVIRYCRRLQI
                     AYSVICLIFLVAHVVSHHSFYEIYYLVSVKILGILIILQMLLLVGTTILYASKRNKDAY
                     IFSVGFGIMALATLGDLLAFYYHDGEYHFFLWKWGIIGLIVSLIVMLGRKFVRSHEQVL
                     QYSRKLEMFNNELQRSEKMEIISELAASVAHEVRNPLQVTRGFMQLLAQNTKQAEKEYF
                     GLALKELDRASGIITDFLTFAKPQLENETKLNVYEELKHVKGILLPLANLSGGSIELDN
                     AKELFMKGNSSKLKQAMINIVKNSIEALDGEGVIRIWAYAKGEEVVIHIKDDGIGMEAA
                     DLERLGEAYFSNKSKGTGLGLMVTFRIIEAMHGTIHFVSEKGSGTEAIIRFPAVPATQE
                     SEV"
     misc_feature    complement(14365..14376)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(14390..14404)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.35"
                     /tool="antismash"
     misc_feature    14407..14423
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            complement(14486..15937)
                     /locus_tag="K1X09_RS23860"
                     /old_locus_tag="K1X09_23765"
     CDS             complement(14486..15937)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015103 - inorganic anion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733915.1"
                     /locus_tag="K1X09_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23765"
                     /product="SulP family inorganic anion transporter"
                     /protein_id="WP_220686206.1"
                     /transl_table=11
                     /translation="MFQWIKQGFFGNSRRDILSGLTVSFALIPEAIAFSIMAGVDPMVG
                     LYASFVIAVSISFFGGRPGMISAATGAMASLMGPLVAMHGIEYLYAATILTGILQLLMG
                     ALKFGRFITFVPQPVITGFVNSLAIIIFLAQLPNFKGESWPMYLMVIGTLLIIYLLPLI
                     TKAVPSALVAIIVMTIIAVWFKAPVQTVGDMGNITQALPFFHIPNVTISLDMIMTILPI
                     SLALAVVGMTESLLTASLVDEMTETGSDKNREIRGQGVSNVITGFFGGMAGCAMIGQTV
                     INVKSGGRTRLSTLVSGVFLLFLIIVLGDVVKQIPMAALVGVMFMVSIGTFEWGSLRTL
                     HRVPLGDAIVMLATVIIVVATHNLAIGVMIGIILSALNFGWKMAKIHAVPHVQPNGTKV
                     YEIRGQLFFGTMMYFVNLFDVNEDPEQVVIDFSKSHVWDQSATNAISKVLNKYKEAGKD
                     IRLVGLNDESQRMVDKVGLASSSTH"
     gene            16279..16977
                     /locus_tag="K1X09_RS23865"
                     /old_locus_tag="K1X09_23770"
     CDS             16279..16977
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733914.1"
                     /locus_tag="K1X09_RS23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23770"
                     /product="hypothetical protein"
                     /protein_id="WP_220686207.1"
                     /transl_table=11
                     /translation="MRDENNRNTLADLTYLEFEAKRRVEDTDMIPQDDLRDVNIYTEQS
                     LSSEDADHIAYDQNEAAPADAKPDERLNPDHSAIDAWEAIGADPDQRTIADERNFSSSG
                     LAEADRIERDRPVDESYIRDVADDVTSREWRAVEGEPPSRPGDEIIGQYSGDTERRLAA
                     DASLTGSGTAFLNQDIFTNYPTEEDEYQPLEDVPDADAIAANSPVDPAAPPTEQMHGTD
                     LLNGSHGEDD"
     gene            17258..17434
                     /locus_tag="K1X09_RS23870"
                     /old_locus_tag="K1X09_23775"
     CDS             17258..17434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015733913.1"
                     /locus_tag="K1X09_RS23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23775"
                     /product="hypothetical protein"
                     /protein_id="WP_201259445.1"
                     /transl_table=11
                     /translation="MKKHPDENPRLVTERDIDEDFGLFVEDSYPDSIPIPDSIKHEKPD
                     GSETSNRGNSSSS"
     gene            17527..17919
                     /locus_tag="K1X09_RS23875"
                     /old_locus_tag="K1X09_23780"
     CDS             17527..17919
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006208681.1"
                     /locus_tag="K1X09_RS23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23780"
                     /product="hypothetical protein"
                     /protein_id="WP_220686208.1"
                     /transl_table=11
                     /translation="MKGLPIHPCGHKITLQQRLASLTGHLVEVNAPNTGLQPGRLQRVF
                     PKNFIKVQGELFVPSSLNSVRVFDVKPPGKTVLVGVRTTFSTRGAFNRIRLVRIGADFI
                     ELLAKDKNRSRILLPLNKVEGIFPVK"
     misc_feature    complement(17926..17937)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.4"
                     /tool="antismash"
     misc_feature    17973..17982
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(18029..18040)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 20.33"
                     /tool="antismash"
     gene            18155..18877
                     /locus_tag="K1X09_RS23880"
                     /old_locus_tag="K1X09_23785"
     CDS             18155..18877
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591670.1"
                     /locus_tag="K1X09_RS23880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_23785"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_220686209.1"
                     /transl_table=11
                     /translation="MLKRRTRWMPALFVILALLLVMTACGQNDKGAESGAGGGKGSTTG
                     ATAPEAEPPKETEVKQNVPDPNASHPIVTIEMENGKTIKLELYPEVAPNTVNNFISLVE
                     QGFYDGTGFHRVIPGFMIQGGDPDGNGTGGPGYAIPGEFTSNGFQNDLKHTTGVLSMAR
                     AQDPNSAGSQFFIMVADAPSLDAQYASFGKVIEGMETAEEIVGLERDQMDKPLEVPVMK
                     KVTVDTLGKDYPDPKKQE"
ORIGIN
        1 ataatcgggc cgtgttataa tggagggcgt aatcagactg catgctggat tctaacacct
       61 tatgcggtca caaggacaac agaagacaat ccatacgcct atcgcggcgt gtgggagagg
      121 ttcgtgaact ccctctataa aaaactatcg tgtcttattc ggtgctgcac cctaagaata
      181 aggcttgttt ttttacggat tcagttcaat gaacttctct ttcttctaca ggttcagccc
      241 tttcggctgt tcttaaaata tgaaggatga gaggtttttt tatgcttaaa aatgaaaaag
      301 cggtcgttgt tttcagcggt ggtcaagaca gcaccacctg cctgttctgg gcgaaggaac
      361 gcttcgccga agtggaaacc gtaacctttg attatggcca acgccataag cttgaaatag
      421 aatgcgcggc acagatcgcc aaggaacaag gcgtgaagca aaccgtgctt gatatgagcc
      481 tgctgaatca gctggcaccg aatgcgctga cgcgcagcga tatcgaaatt gccgaaggcg
      541 acggcttgcc cactacgttt gtggagggac gaaacctgct gttcctcagc tttgccgctg
      601 tgttggccaa ggggatcggt gccaaacatc tgatcacggg cgtatgcgaa acggatttca
      661 gcggttatcc cgattgccgg gatagcttca tcaagtcact caacgttacg ctgaatctgg
      721 ccatggatta cccgttcgtc attcacacgc cgctcatgtg gctcgacaag tcggaaacct
      781 gggagctagc cgaccagatg aatgcacttg aatacattcg cgaccatacg ttaacctgct
      841 ataacggcat caagggcgat ggttgcgggg aatgtcctgc atgcaagctg agaaaagccg
      901 ggctcgataa ctatatgcag cgccgtaatc atgtatccga agggggcgtc tgatatgagc
      961 cgcgagcccg gggctttccg cattgtagag catctgcaga agcttggcga ggacatcgat
     1021 gccggaaacc tgcgttacca tcggaagcgg gtgcttgtct ctaaggagtt taccttcgat
     1081 gctgcccatc atctgcattg ctatgagggt aaatgcaaga acctgcacgg ccacacatac
     1141 aaagtggtct ttggtatcag cggtactccc aatgaagtgg gcattacggt ggatttcggg
     1201 gacattaagg actgctggaa aacggacatt gaaccttatc tggatcaccg ttacttgaac
     1261 gagaccctgc cgccaatgaa cacaacagcg gaaaacatgg tggtctggct gtttgaaaaa
     1321 atggaagaat cccttcgcag cagagagtcg cacgagcaac aaggcacacg aaccgaattc
     1381 gttcgcctgt tcgaaacgcc gaccagctac gctgaggtca gacgggagtg gatgatcgat
     1441 gaataatgtg catgtaaagc ctgagaacga ttcaactgcc tcctccccgg tcatagcagt
     1501 ggaccgtccg attcccgtga tggagatttt cggtcctact gttcaaggtg aaggcatggt
     1561 cgttggccgc aagaccatgt tcgttcgtac ggcgggctgc gattatcgct gctcctggtg
     1621 cgactccgca tttacgtggg acggatccgc caaagacacc atttcgcgca tgaatgcaga
     1681 cgaaatctgg caagagctgt accggctggg cggtgagcgc ttcgatcatg tcaccctgtc
     1741 cggcggcaat cccgctcttc tctcgcagct cggcacgctt gtggatgagc tgcaccgaca
     1801 tggaatcacc gttgccgtgg agacccaagg ttcacgctgg caggattggc tgaatgacat
     1861 tgatgaggtc accatctccc ccaagccgcc aagctcaggt atgaatacgg actggggcaa
     1921 actcgatgat atcgtctcca agctgtccgc tcgggcgccc ggcagatcct tcagcctcaa
     1981 ggttgtcgta tttgacgata aagacctcag ctatgcggaa acggtccatg agcgataccc
     2041 gaacgtgccg ttttatttgc agaccggcaa tcccgatgta ggtacaggcg ataccacttc
     2101 gctggtctcc catctgctgg atcggtacga gttgcttgtc gatgccgtca tgcaatccga
     2161 ccggttgaac gatgtgcgtg tcctgccgca attgcatacg ctcgtttggg gcaataaacg
     2221 cggcgtgtga cgttataata aaaaatacgc tgagcctgat tgagcattta ttcattttaa
     2281 taaaggagct accttatatg gctggaagac aaaaagaaga aatggaagac gttaccctgc
     2341 tcggcaacca aggcacgaaa tatacgtttg aatatgatcc cggcatattg gagagctttg
     2401 acaacaagca tccttaccgc gactatttcg tcaaattcaa ctgtcccgaa tttacaagct
     2461 tgtgcccgat cacaggacag ccggactttg cgaccatcta catcagctac attccggata
     2521 tcaagatggt ggagagcaag tccttgaagc tgtacctgtt cagcttccgc aatcatgggg
     2581 actttcatga ggactgcgtc aatatcatca tgaatgacct catcaaactg atggatccga
     2641 gatatatcga ggtatggggc aaatttaccc cgcggggcgg catttccatc gatccgtatt
     2701 gcaattacgg tcgtccgggg accaaatacg aggagatcgc tgcaaaccgt ctgatgaatc
     2761 atgacctcta tccggaaaaa gtggacaacc gataggtagc ctttttcctg aatgatgtca
     2821 gttctaattt cataaattta taatgatgat aaaaagggtt gcccgcataa ggtgggcaac
     2881 cccttttttt gtcattttat caggaggact acacgattac aggggatatt ccattttctt
     2941 aagccggtaa ttcagacgcc gcttcttgta cagcattttc cccgcttcgg ccacatcgct
     3001 gatcgtccct ttgttgctga tcgaaccgaa tacaatcccg gcgatcggaa tcagctgaaa
     3061 cagcttcttc atcccgaagt tatcggtata agactgaacg acttcacgcc agccctgcag
     3121 ctgtgagaat acctgctctg tcatttgttc atcatcaaaa gtggcgagtt cctcgagcac
     3181 cgcttttttt cccacgatat cggcagatgc aaactgcaag cacttcacga taaacacccg
     3241 ctcccgggga tcgttcggat cataaccgta acaaagcgcc atctcctgca gcaccttaag
     3301 cgattgaccg agcaccatcg gcagatcggc cgctatcgta aatatccccc cgattcccgt
     3361 ggctgctcct tgcgctgcgg cgaatttgac tcgttttacc gtcagcgtat ccgctgcagt
     3421 atccatgact tggagcggca gcttcgcggc agatgccagc gtaagcccgg aagtcgacgc
     3481 caccccctct tcgttctcat cttcaatgga ttcctcctga gcggacttta cggaagggcc
     3541 ggaaaccgca ttcggaccgt ccaatcccgc tgcctgtgcc agaacgttca taaccgcctt
     3601 ctcgcgaacc agatgcttcc cgccgctctg aataaatccg cctacctcat tcaaggcgtt
     3661 tccgattttc tcttgaacag ccttgggcgt gaggcgatcc agcagcatga aaggaattct
     3721 accgagcttc tcccagaaca tgacatcctt ctgctctttc tcccatttca aaatctcttg
     3781 aagctgcgac tccagctgtt gtcgtgattc catctctgtc atcctcacta ctcctatcca
     3841 acattaaaag taactataaa ctgtatacgc agttcaattg aagaaagacg caataaattt
     3901 caaatttaat cttacaacat cacaagcaag attaacaaaa agagaccaac cccatcaggt
     3961 cgatctccct ctttattatc gcaatccgtc aggcgacaga tgtgaaatta tttacccaag
     4021 aaggcattca gcatccaggt atgcttctgt acatcgctga ccatgccggt caacagatcg
     4081 gatgtagcgt cgtccccttc ttgatctgcg gcttcgattc ccgccttcag ttcgccggca
     4141 agctgctcga aatccgcaac cagccgtccg accatctgct cggccgtgtt ttcatcggaa
     4201 acctctttca gcgtggccag gttcagatat tgcgccatac tggctgccgg tttgccgcca
     4261 atggccagca tccgctctgc cagctcatcc acataaccag ctgcagtgtt gtacagttcc
     4321 tcgaatttct cgtgcagcat gtagaactga ggacctttta cataccagtg atagtggtga
     4381 agcttcacgc caagcaaact ccaattggct acctgcgtgt tcaaaatttg ttgaagttca
     4441 ttggttgtcg ttccttgtgt ttgttgggta aagttactca tctatatcgt ctcctttgtt
     4501 attgtattta gacttattct aaatccttgt attaatcata acagattctc gtctcttttg
     4561 caaagggaat cggaaactta agatgaagat aggatgaaga aattaccttc tatttattcc
     4621 tatcctaatt tatttttaag atcaactgct atgataggca tcatatttct ccggctgcaa
     4681 gtaaccttaa gacaacccca ggatcgtttt catttccttc cgcttttgct tcggattcat
     4741 cacatacaac gtatcccctg cctctatgac cgtactcccc ttaggcgtaa tgatccgctt
     4801 ctcccgaata atagccgtaa agaggatatc gtccggcaga ttcagctgct gaatctcctt
     4861 gccgataatg ggcatctccc catccaccag aatatggttg atctcggaat ccgtttttcc
     4921 aagagccatt aactctaata aagtcggtgc tttggcttta tccttctcca ccagcgaaag
     4981 catctgcgtg agcggagaga tcgtggtgcc ttggatcacc gctgaggtca acacaacaaa
     5041 gaacacgaca ttaaaaaaca attctccatg cttgattccc gccagaacgg gatatgtagc
     5101 caggacgatc ggtacggccc cgcgaaggcc cgcccatgaa attaatattt tctcccgcat
     5161 ggcaaatttg gtaaacaaca ggctgctgaa cacgccgatc ggcctggcta taaatatgag
     5221 aatcagggac aataacagtc cttgccatac aacctccgac agctcattcg ggaaaacaag
     5281 cagcccgagc aggacaaaca tgacgatctg catcatccag gcgaaacctt ggttaaatgc
     5341 ctgaatcgtc ttccggtatg tcagttcggt attgccgagc agcaaagcca tcacgtatac
     5401 ggcgagcaga ccgctggctc caagccaagc ggcggcggca tacgacatca cggcgaatcc
     5461 cagtgccgtt acgggatata agcccgagga atcgaaattg atacgattga tcacatatac
     5521 ggccagcatg ccgataagaa caccgacaac cagacccagt cccatctcca ttacgaacga
     5581 aaaaataaga cctatcaaat tcagttccgg gtattcgatc cattcgataa gggatacggt
     5641 tagaaatacc gccatcgggt cattgcttcc ggattcagcc tccagcgtca ttcgaatccg
     5701 tttcttcaaa ttcgttccgc cgagtaccga gaagacggcc gccgcgtccg tcgaaccaac
     5761 aatcgcacca attaacaacc cctcttgtaa cgaaatatcc agaatgaatg cagcgcatat
     5821 tccgacgaca accgttgtca gcaacacacc tatcgttgca agtgaaatgg ccgtccccat
     5881 aaccggcttg atttctttga aatcggtctg catcccgccc tgaaacaata tgacaatcaa
     5941 cgcaaatatg ccgaccagct gtgtgagctc cgcattatcg taataaatga agcggctgag
     6001 aatcatcccg atggcaataa acagcaccag ggcgggcatg ccgaagcgag aagaaaattt
     6061 ggtggtcaat acacctgtca ctagcaaggc gccgcataat aaaatcatgg aatcaacaaa
     6121 acttggcaag ctcatccctc cggtgcgtca aattcgtaca ttatattacc cgaaaatcat
     6181 cgcttcctcg cacacaataa ctactccatc ggtcaaagat taacggcgga gctggcagac
     6241 aagaaatttg caaacgttta ctggaaattc cacgcccaat gactttatac tggtaacaag
     6301 cgacatacat aggggaggcg tcaatcgagt gaacatatct attatgaaaa gcgatcaact
     6361 acatcaagct gttgagctgt ccgaccgtat atttctgaag cagccggaac agccttctat
     6421 gggggtatcc tttcctccga tattctcgcc gggaatcagc cattcctacg gtgcatggga
     6481 tcaagacaaa ctcgtttcat tcatgggatt cgtaccattt accattcaaa ctcgcggtgc
     6541 tcgtttaaat gtctactcca tcggctccgt ctgcacagat ccggaatacc ggggtcagcg
     6601 actcgcaggc agtctcctgg aacagtgtat ccgtcatggc gaagctacgg gggcatcctt
     6661 aatcctcatt tccggcggaa gatccctgta tacccgggca ggcagccgtt tgttcggccg
     6721 tgcactccgg tttcgtctag accgggccgt catggagccc ttacgggcgg taacgggaaa
     6781 acaagtgcgc atccgggcaa tgcagccaca ggatgtattc caccttcaaa agctcatgga
     6841 acagcgggaa gccggttatg ttaccacagc ttcggagctt aacaatctgc tgggtgcaag
     6901 cgcctattcc aacgtgatcc gtctcgagca gcaggtgctt gtcgccgaag aaaacggcgt
     6961 gttgactgca tttgctatca tcgcagtacc cggagctgtg atgactcctt cgagagaatc
     7021 tacccttgta gaatgggggg gaagccctga agcggctgcg ctggtcatag ccgaggcgat
     7081 ctcttccttc aatctgtcag agctaaccgt tccgctgcca tggcaggata aagagctggc
     7141 agcgttaatc caatccgccg gcatcaagcc tgaatatatt cagaatgagg ggaccgtgta
     7201 tttggttagc ggcccggaac tgctccgtca gctggctccc ctgctgccag aggggttgat
     7261 tcaggcagat ggcgagcatg gtccttaccg tcttgccttg aacaatgaag tattggaact
     7321 ggatgatgag ggtttgctct cgattctgtt tgatccggaa tcctcttatc gggctaacgg
     7381 aagcataacc tttgaaccta tccctctccc gtacacagcg ggtcttcaat atatttgacg
     7441 cagatactga aggtgcattt gattccttcc cctagcgggg aggtcatgtg cacccttttt
     7501 atttaattgg ttatggatct gaatctatta cccgacagta cagcgctgct attcatacca
     7561 acgatggtcg ttcgcctatt tttaactgga tatgtgccct tcacctccgc ttccacatag
     7621 gatgaaataa cctatctgat agaaagaggt gcatggcttg agtcatcatc caaaaagagg
     7681 cctgcaatcc caaacaagcc tgggtattcc agggcttttc cccggatacc cgttctatcc
     7741 ttatccatac tatccacctt attatccgat ctatcctttc cctccgtttt atccgggata
     7801 tcccggtcac ggatttcctg gacacggatt tcctggacac gggcatggac atggcccatg
     7861 gcatcctggc ggaccgggac acggaccggg tccgtggcat ccaggcggtc ctggtggtcc
     7921 cagacacgga cacggtcctg tcggcggtcc cggttacggg ccgaggggag cacagagact
     7981 gcgcagtaag cggtaaacac tcgctaacgc gcataacaac ccgcccggtt catcccgggc
     8041 gggttgttat tgctaatcca tatctataaa tggcctttac cgtctcttcg agatctcatc
     8101 ccgatccgga cttatggcac cgccattacc atcaccataa ccttgataca gattagggtc
     8161 cggaaccgca tcctcggtgg cagccgctgc ttcggagcgt gaatctaccg gcgcaccgga
     8221 accgctatag gtgccttcct cacggtaatg atgttcatta agggcgctat tgctgcggaa
     8281 tatatcatat acccggccac cgttcgtttc atctgcatcc accatgacca gaatatggcc
     8341 ttcatctaca tagcccccat attcctcggc ttgctcttct ggaattccga gtccaatgag
     8401 accgcctacc aatccgcccg cgccggcgcc aacggctgct cccgtaaggg ttgccgcgat
     8461 cggaccagcc gcgacgatcg gaccaatgcc tggaatggcc aatgcaccta agccggccag
     8521 caatccggtt acgccgccta acacaccgcc tgtagccgca ccggatgcca agccctcagg
     8581 cgccttggtg ccggtctcct cctgaatatg agaagattct ccgcgatctt tggcaatgac
     8641 agagatttca tcggctctga aaccttgctg ctttagttcc tcaatggccc gggttgcttc
     8701 ctgctccgtc cgaaaagctc ctacaatttt ctgagtcata tgaattcctc ctaatggtca
     8761 ttttcggtta tcgctgtaca ttcctaactt aaacgccagc cgccataatc aaacaaaaaa
     8821 actgatgtag tgtctgtaat aggcctcccc gcagcaccaa taaccccata attatccagt
     8881 tttaaagact ggtaatattt aactttataa atattcatgt taatatagca agtaagcact
     8941 tgtaccttaa aaatagaata gggttggtga ttgcatgaac tggttcaagc cgttcgagga
     9001 cgatcttgct gccgcattct ctgtctgcga agcaaggtta tccgagctcc ctgctccctt
     9061 gaatgaaatc ggtctttcct acttgagaaa gtttgacgtg ttcgagcagg acagttccaa
     9121 aaattacatt tgttatctgc ttccattctg gatgaaagaa ctgaccgaac tccccgccga
     9181 tgtataccga cacctctcag cggccaacat tatcggcatg ttatactact tcattcaaga
     9241 cgacataatg gactcgcccc atgacagtca gtcttccaca gattcgaaac atcatctcgc
     9301 acttgctaac ctgctgtatt acgaatttct cacatcctat caaccctatt ttccagcaaa
     9361 ctccgacttc tggtcttatt tcaaaaacta cacgtttgaa tggtcggaag gcgttatcca
     9421 tgaaacccag gatgattact tcaagcacaa ccctatcatg gttgcaaaaa aggcagctcc
     9481 cgtaaagctg ggaagcacgg cagcattgct tttatctgat caagcaggcc tcattccacg
     9541 aacgaatgat gtaatgaacc atgttttgct taccttgcag atgatggacg attggaccga
     9601 ttggaaacag gatcttgcgg atggcagcta caattgtctg ctgtctctca ttaaatcgga
     9661 attgggacga ccacgcgaca cgaatctgac gatggccgaa gttcaagaag ccatctatat
     9721 caacaacgcg ttgaagccct atgcagacat tgcggcagcg acccatgcct ttctcttatc
     9781 ggtagatata gacgcccccc atctcatctc ctttcatcaa acgatggtgg acgagcttca
     9841 agccgaagca aatcatatcg aaaacagtaa agaaaccctt tcttttggcg gattaaacta
     9901 ttacttgtct attctaagca aaaaataata gattttatat ttgttccatg gtattcttta
     9961 agagtaaaaa ataaccaatt tatttgaaag ggtgattctt atgacgacag aagccatctt
    10021 tcaaacacaa ttgattcaaa aagcttggga ggatcctagc tttaaggcaa aattgcttag
    10081 cgatccgaaa tccgccatca aggaagttct tggggtgcgg attcccgacc acatcgagat
    10141 tcgaacgctt gaagagaacc ctaacgagct gtatctggtc attcctccga atccatcagg
    10201 cgtgatcaag tcagaagcca cagcaaaagc catctggtaa agactacata acagcttgga
    10261 catttcataa atagatgtta tcggcacaaa gagtggggac gatcgccgtc aaagcgctgc
    10321 cgcagcttag cgaattattc gccagctgcg ggaagcgtaa tgacagcatc cgtccccact
    10381 ccttttttac tcgtaaaata aatgtctcca ttcatggcct cgataattcg gaaggtcacc
    10441 atcagaccaa gccccgtgcc cttggttttg ttggagaaat aaggctctcc cagccgtgcc
    10501 aacacatccg gctccatccc ttcgccatta tctataacat gaataaatac ctggtcctgc
    10561 tgacgatagc accttatatg aaccaatccc tcttcgccca gcgcctcgat gctattctta
    10621 acaatgttga taaaagcctg cttaaatttc gaggaattcc cccgaatcgt aatatcctcc
    10681 ggaatatcaa cggtaatcct gcctccttgg aggtgggcaa gcggaccaag tatgccttcg
    10741 atatgtttaa actcctccgc aacccgtagc acggtgtctt tgccgaattc cggtttggca
    10801 aaggtcaaga aatccgtaat aatgccggat gcacggtcta attccaccag agccaaatcc
    10861 aaatattcgc gttccgtggc ttgggctttt ccagttagaa gctgcaggaa tccccgcgta
    10921 acttgcagcg ggttacgaac ctcatgcgca accgatgctg caagctcact gatgatctcc
    10981 attttctccg atcgctgcag ttcattgttg aacatctcaa gctccttgga gtattgaaga
    11041 atccgttcgt ggtttttggc aaaatgccgt cccagaatga caatcaaggc aataatgaag
    11101 ctgacaatcc cccatttcca gaggaagaga ttgtagctgc cacgggtgag gaaaaattgc
    11161 agcagctcgc ttaagcccac aactgcgaag attgcaaagc ctgcattaaa aataacagcg
    11221 tccttattac ccttcacggc ataatacatg gagcttccga ccagcaaaac aaattgaacg
    11281 atcatcacaa tacccattac atgaacggag aagaaataat acagatcgaa ccattgattc
    11341 gaaccccatt gattaacaat cagaaacagc ccgcaaaaca gcgagtaaaa tatctggaac
    11401 ttgcggagtt tgcgcagcaa gcccttccag ccgggtccaa agatggtttc aaaaaagaga
    11461 ctgaacgaag gaagtaagat aaataatgag atgtcatata agtgagtgta aatatttcca
    11521 tattgattaa aaatcgtata aagaaacggg gagtatgtaa acaccagtat gcctacagat
    11581 aaaataatgc aagaaaggga taatacagcg accaaatatt ttctattcaa aaaaatagcg
    11641 cagatcaaca tcaccaatgc gataaatata aaggcgctcc caagaatgat gtccattaaa
    11701 ttcgacttga taaaccgatt aaacatgtcc tgataatcgc cgacaaggat tttcccttca
    11761 atcgtcacat gatctctagc ggtctccagc cagatgtgaa ggtccttgcc gagcatgttc
    11821 tgatgcagag gaagcaagat gtaattaagc tcataattgt acgttcgggt agattcgtaa
    11881 atcttctcat ggttcgcata aaccgcaacc tgctgtccgt ggagcttatc aatcaaaatg
    11941 ccaggggatg tggatgcgat ctcgggaatc ttcatatgaa tccacgcgga tgccttggta
    12001 tgcggcttaa aaggcttcga atcaccggcc gaagtttcca tccagtcatt gatatggacg
    12061 gggacgctct ctggtatccc ccgggactcc gaccagagga ttctccactc cttaatcgct
    12121 gcacgaactg ccgtttcttc ggtggcaaag acaagcctgg ggagcccctg gcttaaagta
    12181 aatacgatga tcaggaacac agcgattctc catccagact tcattgacgc acctcaaaca
    12241 ttataatgag tgaaactctt actgtgttat tcgatgcaac aaaaccttcc accttctaaa
    12301 attcggaaaa atgataaaat tttctattat agatgtaaca aagagagaca ccgttatggc
    12361 atctctcttc catttatact tccgattcct gcgtagcagg tacggccgga aagcgtataa
    12421 tggcctcggt cccgctgccc ttctcactaa caaaatgaat ggtgccatgc atcgcttcga
    12481 tgattcgaaa ggtaaccatc aagccaagcc ccgtcccttt ggatttattg gagaagtaag
    12541 cctcgccaag tctctcaaga tcggcagctt ccattccgat gccgtcatct ttgatatgaa
    12601 tgaccacttc ttctcccttg gcataggccc atatgcgaat aaccccttct ccatccagtg
    12661 cttcgatact attcttgacg atattaatca tcgcttgttt aagtttggaa gaattaccct
    12721 tcatgaataa ttcctttgcg ttatccagct cgatcgagcc tccgctaaga ttggcaagcg
    12781 gcagcaggat gccttttacg tgcttcaact cttcatacac attcagcttg gtctcgttct
    12841 ctaattgagg cttagcaaat gtgaggaaat ccgtgatgat tcccgaagcc cgatccagct
    12901 ccttcaacgc caggccaaaa tactccttct ccgcctgttt ggtgttctgt gccagcagct
    12961 gcatgaagcc gcgtgtcact tgcagtggat tacgaacctc gtgtgctact gaggcggcca
    13021 gctcgctgat gatctccatc ttctccgatc gctgaagctc attattaaac atctccagtt
    13081 tcctggaata ctgcagcact tgctcatggc tgcggacgaa tttacggccc agcatgacga
    13141 tcaaggagac aatcagtccg ataatgcccc acttccataa aaagaaatga tattccccgt
    13201 catggtaata aaaagccagc agatctccga gcgtcgctaa cgccattatc ccaaagccta
    13261 cagaaaagat ataagcgtcc ttgttccgct tggatgcata cagaatcgta gtaccgacca
    13321 gcagcagcat ctgcaggata atcagaatac ccaggatctt caccgaaacc aaatagtaga
    13381 tctcgtaaaa tgaatgatgg ctgaccacat gggcaactag aaatatcagg catatgacgg
    13441 aataggctat ttgaagtctt cggcagtagc gaatgactcg atagggcccg gggccataca
    13501 tattctcaaa ataataatac agcgcaggca gcacggcgaa gagtgaaata tcaaacaccg
    13561 agacccacac gctgccttgc tctccataga aagtgtatag gaacggtgaa tacgtaataa
    13621 gcatagcccc gcttgccaga ataaccacgc taagcgacag ccagctggat accgtatgct
    13681 tcgggaggaa caagcagcaa aagaacatga ccaccgcaat aaacagaaac gagctgccca
    13741 atatgaaatc ttccaggtcc ttcttgataa agcttccacg caaatgctca tattcgccaa
    13801 gtataatatc gccttcgatg cctaacgtca tatccttgac gccgttcgtc catatataaa
    13861 cggtcttgcc ggcatcatcc ggatggaccg gaagcagaag agaatgattc gtgtacatat
    13921 agtctcgctt ggcttcatac acctgttcat tctccaagaa agccacaaca tcctgtccct
    13981 tgatgcggtc aatcatgatg gccgaatgtt tccaagggag agccggtaaa gtaaaacgat
    14041 tccatgctga atacacccca tctgactcgg gggggccctt cttgtctggt attcccgtca
    14101 accagcttct tccctgcagg ttgaccggcg aaacaacctc ctgttgttcg ttatcccaca
    14161 taaactgcca atcggatatc acgatttgag aactctttgc gtccgatttt cccggtgata
    14221 tggtcgatat aatcagcagc agcggcacca ccagcagaag caggaatatg gatttgggca
    14281 tatccttcat ctagtcagca cctctaaccg tctatagtca ataaaagtcc gcatcttctc
    14341 cgtcttgccg attcgacaaa cttcgtgttc atttacaatc aatataacat gaaacgtctg
    14401 ttccgtttgt aaatttttta ttacatacag gcaaatgaaa agggatcgcc cttaacccta
    14461 aggttaaaag caatccctta cacctctagt gtgtggagct tgaagcaagg ccgactttat
    14521 caaccatccg ctgactttcg tcgttcaacc ccacgagcct gatgtcttta cccgcttcct
    14581 tgtacttatt caataccttg gaaatagcat tggtggctga ctgatcccat acatgggatt
    14641 tggaaaaatc aatcacgacc tgctcagggt cctcatttac gtcaaacagg tttacaaaat
    14701 acatcatcgt tccgaaaaat aactgtcccc ggatttcgta taccttcgta ccgtttggct
    14761 gcacatgcgg tacggcatgg atttttgcca ttttccagcc gaaattcagc gcgcttaata
    14821 taattccgat catgaccccg atggccagat tatgcgtggc caccacgatg attaccgttg
    14881 ccagcatgac tatggcatca cctagtggta cacgatgaag tgtgcgaagc gatccccatt
    14941 caaatgtacc gatggaaacc ataaacatga ccccgacaag cgctgccatc ggaatttgtt
    15001 tcacgacatc accgagcaca atgatgagaa acagcaggaa cacaccggac accagcgttg
    15061 ataaccgggt gcgaccgccc gatttgacat taatcactgt ctgtccgatc atggcgcaac
    15121 cggccatgcc gccgaagaat ccagtgatca cgttggaaac tccctgcccg cggatttcgc
    15181 ggttcttgtc gctgccggtc tccgtcatct catccacgag tgacgccgtc agcagcgatt
    15241 ccgtcatccc gacgacagca agagccagag atataggcaa tatcgtcatg atcatatcca
    15301 aactgatggt tacattcgga atgtggaaga acggaagagc ctgcgtaatg ttgcccatgt
    15361 cgcccaccgt ttgcacagga gctttgaacc acaccgcgat gatggtcatc acaatgatgg
    15421 caacaagcgc cgaaggaact gctttggtaa tcagcggcag caagtagatg ataagcagcg
    15481 ttccgatgac catcaagtac atgggccacg actcgccctt gaaattcgga agctgggcca
    15541 gaaatatgat gatggccagt gagttcacga atccggtgat gaccggctgg ggaacaaatg
    15601 taataaaccg cccgaatttg agcgccccca tcaacaattg caaaatacct gtaagaatgg
    15661 ttgccgcata caaatactcg atcccgtgca tcgccacgag cggccccatt aatgacgcca
    15721 tggcccctgt tgctgcggag atcatgccgg gacggccgcc aaagaatgaa atactgactg
    15781 ctatcacaaa agaggcatag agtccaacca tgggatcgac gccagccatg atggagaatg
    15841 cgatcgcttc cggtatgaga gcgaacgata ccgtcaatcc tgacaaaata tccctgcgcg
    15901 agttgccaaa gaagccttgt ttaatccatt gaaacaaagt cctgatcact tcctgttcta
    15961 ttatagtggt ttgacaatcc actctcagga ttgtcctggt ccgataatca ctttttcgat
    16021 tataacggga tcatttcaaa atttcattat tcaatttaag gaacctatcc cacgatatca
    16081 ttcattttct cccgtttgtc ttgaattacg tccatttttc caatttaaaa atattcataa
    16141 tacggcaatg acagggaaag ataaaacttg tttggtttat cataacctga aaagatccaa
    16201 gattcattct tgattcagcg ggtaaagtcg aagtatagaa acctattgta tttgaactct
    16261 tggaaggaga tggaccctat gcgagacgaa aataaccgca atacgctggc agatttgaca
    16321 tatttggaat tcgaggccaa acggagagtc gaggatacgg acatgattcc acaagatgat
    16381 ctgagagacg tcaacatcta cacggagcaa agcctaagca gcgaagacgc ggaccacatc
    16441 gcctacgatc agaatgaagc tgcgcctgcg gatgcgaaac ctgacgaacg tctgaacccg
    16501 gatcacagcg ccatcgatgc atgggaagcg atcggtgccg atcccgatca gcggaccatt
    16561 gccgacgaaa gaaacttttc ctcctcgggg ctggccgaag cagaccgaat cgaacgggat
    16621 cgaccagtcg atgaatctta cattcgcgat gtcgcagatg atgtaacgag tcgggaatgg
    16681 cgagctgtcg aaggtgagcc cccttctcgc cccggagacg aaattatcgg ccaatattcc
    16741 ggcgatacag aacggcggct tgcagctgac gcttcattaa ccggcagcgg aactgcgttt
    16801 ttaaatcagg acatttttac gaattacccg accgaagaag atgaatacca gccgctggaa
    16861 gatgtaccgg atgcggacgc catagcggct aacagcccgg tggacccagc cgccccgcca
    16921 acggaacaga tgcacggtac cgatctacta aacggcagcc atggtgagga cgactaaacc
    16981 tgcaaaaccc gcctctccta ataggaaggc gggttttata cttgtatggg ttcgatcctc
    17041 tattttccga atatgatatc cagccagccg agaaatgaca tccacagcag gatgccgatc
    17101 aaggtacccc atatgagtgc tgttaatatg tttccctttc tttccatgcc tatgcctccc
    17161 atacaacatc ttttatagta aaacagtatg ggtcgagcta tcagttctta tactagccaa
    17221 ccatttcaaa gactagattt gataggagga acagccgatg aagaagcatc ctgacgagaa
    17281 cccacgttta gtgaccgaac gcgacattga tgaggatttt ggcctgtttg tcgaggattc
    17341 atatccggac agtatcccga tacccgacag catcaaacac gagaagccgg atggcagtga
    17401 aacgagcaac cgcggaaact cttcatcttc ctgatccttc acaccggaaa tgtaacctct
    17461 acgttcaccc aagtcatacc ttccaacata cactacacca tacgaccctg gaaggatgat
    17521 gctgatatga aaggattgcc gatccatccc tgcggacata aaatcacgct gcagcagcgg
    17581 ctggcctctt taaccggtca tctggtagaa gtcaacgcac cgaacaccgg tttacaaccc
    17641 ggacgtttgc agcgggtatt cccgaaaaat ttcatcaagg tacagggcga gctctttgtg
    17701 ccgtccagtc tcaactcggt tcgggtattt gatgtcaagc cgccgggcaa aacggtgctg
    17761 gtaggcgtgc ggaccacctt ctctacccgt ggtgccttta accggatccg tctggtcaga
    17821 atcggagccg attttattga attgctcgcc aaggataaga accgttcccg gattctgctc
    17881 ccattaaaca aagtggaggg catattcccg gtgaagtaga gacagttaaa cgttttcctc
    17941 aagcttccag acttgcgaca agtccggagg cttatttttt gattatggat actcaggcag
    18001 gaccgactgg cttctgtgac attacgtcga taacgttttc ctatagatta tgtatactca
    18061 cctttttcga ttttcagtac ttgtccaacc tgtgctaaaa tatgatacag attaaatact
    18121 taaggcttga taaggaatac aggaggaatc aatgatgttg aaacgcagaa cacgctggat
    18181 gcccgcccta ttcgtcatcc tggcgctgct gctcgtgatg acggcatgcg gtcagaatga
    18241 caagggagcc gaaagcggcg caggcggcgg aaagggctcg acgaccgggg caacagcacc
    18301 cgaagcggaa ccgccgaagg aaaccgaggt taagcagaac gtgccggacc cgaacgccag
    18361 ccaccctatc gttaccattg agatggagaa cggcaaaacg ataaagcttg aactttatcc
    18421 ggaggtggcg ccgaacacgg tgaacaattt catctccctg gtggagcaag gattctacga
    18481 tgggacaggc tttcaccgcg tcatccccgg cttcatgatt cagggaggcg accctgacgg
    18541 taacggaacg gggggacccg gctacgctat tcccggcgaa tttacgtcca acggctttca
    18601 gaatgacctg aagcatacga caggcgtatt atcgatggcc cgggcgcagg atccaaactc
    18661 cgccggatcg caattcttca ttatggttgc ggatgcacct tcgctggatg ctcagtacgc
    18721 atccttcgga aaggtgatcg aaggaatgga aaccgcagag gagatcgtgg gcttggagcg
    18781 ggatcagatg gacaaaccgc ttgaggttcc cgtcatgaag aaagtgacgg ttgatacgct
    18841 cggcaaggat tacccggatc ccaagaagca ggaatagcat cttttcggac tagcattgcc
    18901 tcgcaagttc atggcattgg cacacatccc ggatcacttg tgaatacagg cataccggca
    18961 ggtttaatga tacaatcaaa ataagacccg tacgctgaat tgagcgtgcg ggtctttttt
    19021 taagttacag cctgtttcta ggaatgggcc ggcttctcga tgacgtacaa gcaagtgctg
    19081 tcaggcagct tcaccggctt tccatcttca tccatgaatt cgattcgatc agccaatgcc
    19141 tcagcatatc cttcctgcag ataatgctgc tgcacgcgga taatcgcctc aggacctagc
    19201 gtcctgcgta tacattccgc atactgcgta ggcgtaaagt agccaaactg ctcttgcact
    19261 tcatgaacgt aagcttcagc gccccaagta taggtgtaca ggaactccat tgcatcgttc
    19321 acgggcatgc gcacttccgc ctcggccagc tgctcgtatg atatgacccg ccctttgaaa
    19381 tccgaggcat atcggatcag ccattccata ccgtcggcct caagaaagcg gatccttctc
    19441 caggcatcct cgggctcagt cataatcccg tcacggatga tgatgcgccc ccctggagca
    19501 agcacatcat aggcactgag caaggctgcc tccacggtcg ccgtattgaa gcgtgaaccg
    19561 tccgtctcaa tgtacgaata caactcatgc aaaatcgagg agaagataac cgtatccaca
    19621 ctccccggct ccacgtaatc cctgaggttc agcgcgtccc ccttcatcac ttcccatgct
    19681 ttgtgctcca agcgtttacg tttctccagc gcttcaatca cgttcgagga gatgtcgatc
    19741 ccgaccgggc gcgcttgcgg cagccgttcc tcgatcagat caagcagcac gccgcctccg
    19801 ggcccgatat ccagcaccgc cgttcccgtt atataatcca gaatcacttt tttataatct
    19861 cccgtgctgt tcatatcgct caaataactc tcttcgttat gaaatctatc gtaggcgtcg
    19921 cggcgcaggc cgaacaggtc gaacaggagc aggaccgctt tctcatagag gggcgatttc
    19981 tccgcttcga tgcaaaattc aattagtttc tccgctgctt gcgagaattc gaaggtgaaa
    20041 aataccgtat ccggcagctc cggcttccgt tcaatccggt ggctcagatg cgggttggcc
    20101 atcaccgacc catgaaggca agacgtccaa tccgtttggc gcaaatattg ctcaatcatt
    20161 ctcttcttat atacgttcag cttcttgacg cctttgtaat cgtaatacat atcgttcatc
    20221 agcgactcaa agcttaagtg
//
