LOCUS       NZ_JAIFIS010000001     20822 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Paenibacillus lautus strain PLV Scaffold_1, whole genome shotgun
            sequence.
ACCESSION   NZ_JAIFIS010000001
VERSION     NZ_JAIFIS010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus lautus
  ORGANISM  Paenibacillus lautus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Endophytic bacteria from Leucojum aestivum L. in vitro plants, a new
            source and elicitor of Amaryllidaceae alkaloids biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7405488)
  AUTHORS   Ptak,A., Gurgul,A., Jaglarz,A., Moranska,E., Laurain-Mattar,D.,
            Spina,R. and Simlat,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-2021) Center for Experimental and Innovative
            Medicine, University of Agriculture in Krakow, Mickiewicza 21,
            Krakow 31-120, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.14.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly         :: GCA_003590055.1
            Genome Coverage                   :: 496.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019641495.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 05:30:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,260
            CDSs (total)                      :: 7,166
            Genes (coding)                    :: 7,057
            CDSs (with protein)               :: 7,057
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 2, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 109
            CDSs (without protein)            :: 109
            Pseudo Genes (ambiguous residues) :: 0 of 109
            Pseudo Genes (frameshifted)       :: 38 of 109
            Pseudo Genes (incomplete)         :: 74 of 109
            Pseudo Genes (internal stop)      :: 16 of 109
            Pseudo Genes (multiple problems)  :: 16 of 109
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:25:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3089334
            Orig. end                         :: 3110156
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIFIS010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20822
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20822
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20822
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10822](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10822
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            986..2767
                     /locus_tag="K1X09_RS14460"
                     /old_locus_tag="K1X09_14435"
     CDS             986..2767
                     /EC_number="2.7.13.3"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735487.1"
                     /locus_tag="K1X09_RS14460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14435"
                     /product="sensor histidine kinase"
                     /protein_id="WP_220685196.1"
                     /transl_table=11
                     /translation="MTKLFHWYASLGLATKQFIYLFIVTLLLVQVLAWRNLHEAESLLR
                     NQVIRDAELLVSRTNQYIDASLDSVENMLLLLSTRADLLEEGNEEAAVETLRKFAGINN
                     SIARTLYMIRADGEVFSSSQVVHDIIGNPKLNQLYELALINYGAINVSEPYDSPMSGRT
                     LAYVLPIAGAGNKVKGVVVAELNLDLLTERIAPMIYQSYILFTKEGSVINRLDSRDKLL
                     PFQAASYPPKLEESFRGQLALLKVGVSGIEGDSLNPLVAVKSTKNRLGWSLAAFIEEDY
                     FYQDLQRLNNNYRTASIVWIIMLLISAYLLSRSFTHPIRRFVEKMDRLNNFEVVAKLPV
                     TRMDEIGRLTQSYNAMLERIQSLLLKTKSAEEQKKEYELKMLRSQIAPHFLYNTLACIS
                     SLAKQQRIDELRDTIRSLVKLLSFSFDKQSEYVSLEEELEGLRMYMHIQQVRYGEQYQF
                     RIDINPDLLQYRILKLTLQPLVENALFHGLTPNHGGLIIVKGGLMKGILRLYVRDNGIG
                     IKREKRSRLLLENQDGGQRSMYRFTGIGLRNVHERIRIHHGETYGLRIGGAEGAGTVVR
                     VDMPVLKEYDERLGIWR"
     gene            2856..3095
                     /locus_tag="K1X09_RS14465"
     CDS             2856..3095
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1X09_RS14465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_220685197.1"
                     /transl_table=11
                     /translation="MARFLPEGVPDQIQSLAAASFQQIAEFGVTTITINSFQLQIMDID
                     ADESNFEANDYERNAYIFYVSVYIEEASGPLYLP"
     gene            3193..4095
                     /locus_tag="K1X09_RS14470"
                     /old_locus_tag="K1X09_14440"
     CDS             3193..4095
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009592417.1"
                     /locus_tag="K1X09_RS14470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14440"
                     /product="ABC transporter permease"
                     /protein_id="WP_372238808.1"
                     /transl_table=11
                     /translation="MILKLAWRFKAFYVMLLPGIIYFVIFRYFPMYGVIIAFKDFAILD
                     GITGSSWVDPWYKHFQSFYESPYFSQLLTNTLLISLYKLLWGTLPPIMLAVLLNECRVR
                     WLKSIVQTLTYMPHFLSWVIIFGILLTLFSQNGGLINRWIVEAGGSSIPFLTSTEYFRS
                     ILVGSEVWQNLGWGAIIYLAAMAGIDPTLYEAAKVDGASRMRMIWHITLPGIRSIIVLL
                     FVLKLGHLLDAGFDQIYILYNIQVYPVADIIDTWVYRTGLQQLNFSLASAVGLFKSVIG
                     LILVLGANRVAKKWGEGIW"
     misc_feature    3194..3210
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.68"
                     /tool="antismash"
     gene            4089..4949
                     /locus_tag="K1X09_RS14475"
                     /old_locus_tag="K1X09_14445"
     CDS             4089..4949
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735485.1"
                     /locus_tag="K1X09_RS14475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14445"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_194542792.1"
                     /transl_table=11
                     /translation="MVRGLDDKIFNTIIYVILGICGLVAILPILYVVSVSITPFGEVLR
                     NGGFILFPKEITFSAYRTLLTESNIPKAFQITVLITVIGTAVNLVLTGLMAYPLSRRNL
                     PGRNFFLLMIVFTLLFSGGLIPTYLVVKSMGLLDSIWAMILPNAVWSFNVLIMKSFFEG
                     LPEELFESARMDGAKEFRILLQIVTPLSVPVLLTVGLFYLVGHWNEFFQAIFYVTDRTL
                     YPLQVVVREILMQSQQPLENAENMMPTQTMQMASVMIASLPVIVIYPFLQKHFTKGMLL
                     GSIKG"
     gene            4982..6520
                     /locus_tag="K1X09_RS14480"
                     /old_locus_tag="K1X09_14450"
     CDS             4982..6520
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735484.1"
                     /locus_tag="K1X09_RS14480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14450"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_220685198.1"
                     /transl_table=11
                     /translation="MKKLGTLLVAVSLAGAMLSACSGGNSSENPGNPSGATAKPGTETM
                     EQPNGKPVKLDIIETGNNLPTPDKDIIKQELDKALNIDLNLTVYPAADDYNNQLNVRMS
                     SGNFPDLFMVDRQQLIQFSKQGLLLDLTPYMDKLEQTVAFIGVDSVKKGMVDGKVYGIS
                     KSPQIPYNTLWIRKDWLDKLKLEVPTTVEQLASVAEAFTKNDPDGNGKPDTFGLTGSKL
                     SAFSTVFGAFGVGMPGNFYEKDGKVVSALHEPAMKDALAFIKDMIESGSVDPELLANSG
                     LQHQEKAIKGQAGIVYIDWPNMTKEQFVEQIKTVNPNAEWLQIAAPSGTGGQFDGSWDI
                     GAAPGRYAIPKALEKDPEKLQRVFDLLNYISNPDGGSLLVQFGVKDTHFTLEDGKPLMT
                     DKAGEVGHSWLYQFTGRPEMEYLQAKFAAQSAAIEFANDQPRIEALNGFVDNPEGYNPA
                     DATRYMEEEIAKFIYDKRPLTEYDDFIKTLETSMNYKALVDSAMDQLKALGYGD"
     gene            complement(6571..7368)
                     /locus_tag="K1X09_RS14485"
                     /old_locus_tag="K1X09_14455"
     CDS             complement(6571..7368)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735483.1"
                     /locus_tag="K1X09_RS14485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14455"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_220685199.1"
                     /transl_table=11
                     /translation="MEFSRFLEPDLQYHVYVKDTPQFQKTHDTYDHWTLFIVEEGAFNY
                     RMGSQSGRAVKDDIVLCPPDLTFYRQTDGLSFHLMGFQWINSLEEPPRVADFPTFGKLR
                     LLNNKRFQSTLSQFREAQYLHAGIGHMYKKHLLRDLLYLLQIEQSEQHTMTLFSEDPTL
                     GRALHLLQQQAEFGLSLKSIAVELGLTQVQLTRLFTREFRITPSAYATNLRMDKVKQLL
                     VYSSLTLAQIAEHCGFTDEHHLSKSFKKLCGVNPSLYRKTHSV"
     misc_feature    7422..7438
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.06"
                     /tool="antismash"
     gene            7489..8304
                     /locus_tag="K1X09_RS14490"
                     /old_locus_tag="K1X09_14460"
     CDS             7489..8304
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735482.1"
                     /locus_tag="K1X09_RS14490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14460"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_194542789.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-20, bitscore: 73.1,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTAKLEIPKLMEQFHEQGYLVIPDILSQEQVSRLNAAIDEIVLA
                     EPETLSHNIYNSVERHAEIAALIDQPAILPLIVNLLGHNIQLHISHLTIRQPNPSEAQT
                     ATHSFIDWHQDGPHPQFPVINGMTATYYIKVCYILSDMSEPDRGNTKVIPGSHKQPYNP
                     NHKDVRQQLDGEVQVCGKPGDVFVFAQNLWHAGSPNRSAFTRRQLFLGYSPIWMRPIDY
                     HSASVSLLKDADPIRRQLLGQISDNKFNYYVPEDSMVPLKSMLIHPSSQ"
     gene            8373..8564
                     /locus_tag="K1X09_RS14495"
                     /old_locus_tag="K1X09_14465"
     CDS             8373..8564
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1X09_RS14495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1X09_14465"
                     /product="hypothetical protein"
                     /protein_id="WP_194542788.1"
                     /transl_table=11
                     /translation="MAKTSSQIEAAVRKVTGGCLLSAVKVWPRQCRRRTSWPRRKFEER
                     GRHFVELVGAQLRSEGKD"
     misc_feature    complement(8927..8941)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.72"
                     /tool="antismash"
     gene            8962..9567
                     /locus_tag="K1X09_RS14500"
                     /old_locus_tag="K1X09_14470"
     CDS             8962..9567
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009595415.1"
                     /locus_tag="K1X09_RS14500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14470"
                     /product="hypothetical protein"
                     /protein_id="WP_259445268.1"
                     /transl_table=11
                     /translation="MENQSCVKYNDLYSLYQQKNDSAFVYLVKHASETIPLADTLMAIS
                     ESKENEDPAKIRQLIDKAKIQAEEIDNQISIFIEFSDTYSNNAVPKHFVNNAAMTTDEQ
                     LDMFILAREARIWWSLYDISYSYWKSNPKTIGTKTRETLRSLATELYELNKTITSFKDN
                     DAAHMFYLAENYKALMLGKLKPHLERLKKIQDHFSGHK"
     misc_feature    complement(9897..9910)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.17"
                     /tool="antismash"
     misc_feature    complement(9928..9941)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.88"
                     /tool="antismash"
     gene            10001..10822
                     /locus_tag="K1X09_RS14505"
                     /old_locus_tag="K1X09_14475"
     CDS             10001..10822
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735719.1"
                     /locus_tag="K1X09_RS14505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14475"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_259445269.1"
                     /sec_met_domain="phytoene_synt (E-value: 5e-12, bitscore:
                     44.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-26,
                     bitscore: 92.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGALINNIAMKEAMSMLKKTSRTFFIPISYLDSGLREAVASGYL
                     CMRAIDEIEDHNELADELKVELLLEIYETFKTQDVMETQFILSPHRTVLPAVTMQIGKW
                     ALLCPSSSADIVYRYISKMALHMAEWVQNGWSIHTEEDLDRYTYSVAGMVGEMLSELWY
                     WYDGTRSDLTKAIAFGRGLQAVNILRNREEDLKRGVDFFPDGWGYKEMQQYTHRNLQIA
                     DSYIAELKDGPALKFCKIPLALAHATVNLIASGGNKLTRDAVLKIVNRVTG"
     gene            complement(11058..11912)
                     /locus_tag="K1X09_RS14510"
                     /old_locus_tag="K1X09_14480"
     CDS             complement(11058..11912)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007131464.1"
                     /locus_tag="K1X09_RS14510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14480"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_220685200.1"
                     /transl_table=11
                     /translation="MPQIDRHKNRTVDIEFVAAEDFAHFPYPERFTLVFVTNGSIKGIL
                     NERPITISAPAILCLSEEDTIQVLDKNNASASSFSFHPDFLNSTPHSETQTYFPTDMKI
                     ETGLSLFRKSPERTGIPRITEKAYPQLFEWFFVLGTEVYAQSDALWACRIKKYFIQIMG
                     VLEDLNRHSEQSPVDLVLEYIHTNYPDKITLEDLTKCAYLNRVSLNKMFQERCGCTAMG
                     YLLSHRLKVAGNLLTHTDMTLNEIARATGFEYDTYFIKQFTAKKGMSPTAYREISRKFS
                     AVQ"
     gene            12018..13019
                     /gene="gap"
                     /locus_tag="K1X09_RS14515"
                     /old_locus_tag="K1X09_14485"
                     /pseudo=""
     CDS             12018..13019
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440686.1"
                     /locus_tag="K1X09_RS14515"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14485"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAINIAINGFGRIGRLAFRQLFDTEGYRVAAINDLTSPQMLAHLL
                     KHDTTQGRYDAKIGYNENSLNVNGVDIPIYAEKDPGKLPWKELQIDVVLECTGFFASKK
                     ASAAHIEAGAKKVLISTTAGKDVPTIVFGINEHTLAKNDTIVSAASCTTNCLAPMAYFL
                     NELAPLKKGFMTTIHAYTNDQNTLDGPHPKIDLRRARSAAGNIIPTSTGAAKAIGLVIP
                     SLDGKLDGTSQRVPFMAGSLTELTAVVGGSVTVE"
     gene            13240..13419
                     /locus_tag="K1X09_RS14520"
                     /old_locus_tag="K1X09_14490"
     CDS             13240..13419
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735435.1"
                     /locus_tag="K1X09_RS14520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14490"
                     /product="hypothetical protein"
                     /protein_id="WP_194542786.1"
                     /transl_table=11
                     /translation="MNYYKGAVPGSDNFIYFKSEVKLKESDVVVLDDKKYFIESIDNGL
                     LILQRVGSIISVSV"
     gene            complement(13840..15453)
                     /locus_tag="K1X09_RS14525"
                     /old_locus_tag="K1X09_14495"
     CDS             complement(13840..15453)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007128037.1"
                     /locus_tag="K1X09_RS14525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14495"
                     /product="ABC transporter permease"
                     /protein_id="WP_220685201.1"
                     /transl_table=11
                     /translation="MQEKFARSRVLFVQYLKRDWKKIIIWVLGLGLFSAGFVPAFEEMG
                     KGQGLQGMYETLQNPAMISMVGPTPIENAADYTLGAMYAHEMLLFCGLFAMIIAALHVV
                     SHTRKEEDLGLTELVRSFQVGRQANSLAVIAEVVMINILLALVIGGMMTSFGVDTISAE
                     GSFLFGASIGMAGILGAVIALVMAQIMPTSSGATGSSLGIVGLLYIVRAGTDVSNVDFS
                     MINPMGWTYLTYPFTENNGVPLILAIVFSVIVVIIAFVLEGGRDMGAGYLPERDGRESA
                     KKSLLSVPGLFTKLNKGVMISWLIAFVVMGAAYGSIYGDMQTFLESNEIMSQMFTISGV
                     SIEEAFTGTIMMVMIGLVSILPIAIVNKLFSEEARQHLSQLYATKVTRAQLYWTSVILA
                     IVAGIVGILLASSGLGGTAISALGDGSSMNMRDFLAAGYNFLPSVLFFIALAALALGWA
                     PRLGKAVYAYLGYSFALNYFGGILDLPEWFSKTAVQSWIPRMPVDSFDAATFITISVIS
                     VALMIMGYLGYRRRDMVEGA"
     gene            complement(15477..16358)
                     /locus_tag="K1X09_RS14530"
                     /old_locus_tag="K1X09_14500"
     CDS             complement(15477..16358)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007128036.1"
                     /locus_tag="K1X09_RS14530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14500"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_194542784.1"
                     /transl_table=11
                     /translation="MTNIVEVQGLQKRFGKFKALHDVSFAVNAGEVVGFIGPNGAGKST
                     TIRILLGIIHRDAGDAKIFGKDVWKDSLEIHKRISYVPGDVALWGSLTGGEIIDLFMKL
                     HGGGDKNKRDYLIKRFELDPKKKAKGYSKGNRQKVGLIAALSVDSDLYIFDEPTSGLDP
                     LMEAVFQDEVEKIKLAGKAILLSSHILSEVERLADKVVIIRQGKVVETGTLDELRHLTR
                     STVTIVTQGNVAIMASVNGVHDFKQSGNQATFFADNEFINEILSEAAKLGVKKFESVPP
                     TLEDLFMRHYEV"
     misc_feature    16636..16645
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            16677..17273
                     /locus_tag="K1X09_RS14535"
                     /old_locus_tag="K1X09_14505"
     CDS             16677..17273
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015735562.1"
                     /locus_tag="K1X09_RS14535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14505"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_220685202.1"
                     /transl_table=11
                     /translation="MNGFEKRTQEKKNQVLEATFKLINTEIGIENVTVAEIARHANVGK
                     TTIFKYFGSKENLVHEVFKYFLTQMGETAREIMAENKPFEETIIAMSQNKINYLKKINK
                     QFYLYLMDYFTKKDDDGLSLMMQQYVKESYSLMLDLFHRGRKEGKVDLKYSDEFLLIYF
                     QALVEGISSPHIYPKILPYTAQWTELLIKGIAPSK"
     gene            17231..17692
                     /locus_tag="K1X09_RS14540"
     CDS             17231..17692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688364.1"
                     /locus_tag="K1X09_RS14540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_259445270.1"
                     /transl_table=11
                     /translation="MDGIADKRYCAKQIKHIFQFFLTGLFGNVNGIMTEPLNELEIKLT
                     ETLLYIPENILLKIYLNVLKGESFPLIKDILRRMRVDGYLRPDIDDDLIFFMFESMQFN
                     LVLFFREFDIKDSKLQHKISKYFADFMGHGLLEDHKHSEIVSDLKKAKE"
     gene            17750..18886
                     /locus_tag="K1X09_RS14545"
                     /old_locus_tag="K1X09_14510"
     CDS             17750..18886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015383777.1"
                     /locus_tag="K1X09_RS14545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14510"
                     /product="choline esterase"
                     /protein_id="WP_220685203.1"
                     /transl_table=11
                     /translation="MKTFEAFPEPIGSYTVGRTQMDFEYTASDHLKRELTAFVYYPSDS
                     SEGKTTSTYMFPEVYEMLDEQPLLTALKDAYSIDIKTQCYDDLALSGKEKRYPVLFYVC
                     GGGGSPEWGTVISTDLASLGYVVVSIGHQNSTMYKRKDGRLFNVSKGFSDVIMAFSEDP
                     EMVALAGKMEMRPDDETAIEMCHKVLTLPVLAKITEYSELQAEDVRYVADYLYKMDSGE
                     LNSIFKGRLLLDIGMGIVGHSYGGPTTAIVCRDDDRFACGIGLDSAAFGLQGSDLNKPF
                     LLLYCEPNYNMNAIIGANNSMQTYYFSVDRVAHLDYCDIVFTSVNEELRGERDAMEMRN
                     LVTDYTKNFFDQYILQKAASVESLAYDGVDLVKKTSNK"
     misc_feature    19095..19109
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.01"
                     /tool="antismash"
     gene            19263..19520
                     /locus_tag="K1X09_RS36215"
     CDS             19263..19520
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1X09_RS36215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_259445271.1"
                     /transl_table=11
                     /translation="MTIPDGVQIIGLGEATHNNGEFQSVRLDVFKVLVEKYGVRTFVLE
                     EDFANSELMNRYLSGEDIELQEAWEKWFPFYHTQEMAELF"
     gene            19525..20592
                     /locus_tag="K1X09_RS14550"
                     /old_locus_tag="K1X09_14515"
     CDS             19525..20592
                     /EC_number="3.1.1.-"
                     /GO_function="GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016994.5"
                     /locus_tag="K1X09_RS14550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1X09_14515"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_259445272.1"
                     /transl_table=11
                     /translation="MREYNRSASSEEQLQYWGMDVQRSELMIPTLDNYLKVVDRELSKE
                     LNRLQVGSSDLWEISNQLLGNIFTPNSERAWTKSDYKQLQRQWSPLIQKDIQLIERLIH
                     RMTMNADLLIAKSDEQMYEAAMQNIQSIYVTYSVMNDSLLRDFSEGNGYLHFVSSANHR
                     DKAMKEKVDWILNQANGPILIAGHNGHISKKNRAAADCFVNAAKEQNINVDSKMIKLTY
                     IGELLEESYGDAYYAIGTSFNEGVLAADSKIITDPNPPTFTIHSDNLLLNSLKDLPADR
                     YFLDFDRAKQDEQLNRLISKDELKMPYVGSLNGVDLNDPNHRKIENYYSGMILDESFDA
                     LIHFRKVNVFTPYER"
ORIGIN
        1 agcaggaaaa cagggatcca aattggctga cttggctgac ggtacgggag cgggaatatt
       61 ttgttctgct tgaaggcaga actcctccca atgctgttct tgagtcactc cgcacggtcg
      121 ttcaacattt gacggagctg ttgaatcggg aagagaccaa gcaggagagc ttggcgacag
      181 tacatgccat ttttagcaaa ccggtcacat cgaaggaagg agttgcatcg gcgctcgcct
      241 attcgaacga gtggaaagat gcgctgtttt tcgaccgatg tcccgaggaa agcgctgtgt
      301 acgctcagca ttcgttgcct ctatcggatc tgacggaaaa gaaaacgaag gaattaaacg
      361 agctgctgag aaaagcatcc ttgtctcctg cgagcttgaa ggaatgcttg cttggcgagt
      421 tcagggactg gtgcattgca gagcgtgtga agcctagtca actgaaggag tggatactca
      481 attggcaggt tgattggcac aggcagcaag agggcgctga gctgagcgca gcccgtatga
      541 ggttattaat ggacgcagga acgttagctg agatgctcgc caatattgtt cagaatatag
      601 aagctgccga gctagggaag tcgcattcgc gctttgagat tcgtttggcc gtgcaatgga
      661 tcaaagacca tctcaaggag ccgatctcgc tggctgttat ttcgaagcag gtagggctga
      721 gcccacatta tatcagcaaa ttgtttcgtg aggaaacggg gagtacggtc aatcagtata
      781 ttacccgtct tcgtatggag aaggcgatcg agcttcttag gcattcgaat aagaaggtat
      841 atgaagtcgc ggaagaggtc ggcattccga gctaccgtta tttcactgtt acgtttcgaa
      901 attggaccgg ggtatcgccg acggactata aacggaaagg ctgaaagcac gggagagtga
      961 gaacgagcgc gaaggaaggg tggaaatgac gaaactgttt cattggtatg ccagccttgg
     1021 tctcgctacc aagcagttta tttatttgtt catcgtgacg ctgctactcg ttcaagtgct
     1081 tgcatggcga aacctccacg aggctgaaag tctgcttcgg aatcaagtca ttcgcgatgc
     1141 agagctgctc gtcagccgga cgaatcaata tatcgatgca agtttggaca gtgtggaaaa
     1201 tatgctgcta ctactctcga cccgtgctga tttgctggag gaagggaatg aggaggcagc
     1261 cgttgagacg ctgcgcaagt tcgcggggat taacaactcc attgccagaa cgttgtacat
     1321 gattcgagct gacggcgaag tattttcaag ctcgcaggtc gttcatgaca tcataggcaa
     1381 tccaaagctg aatcagctct atgagctggc gcttattaac tacggggcta ttaatgtgag
     1441 cgaaccttat gattcgccaa tgtcggggcg aacgcttgct tacgtcttac ctattgcggg
     1501 tgcaggaaat aaggtgaagg gtgtcgtagt cgccgaactt aatctcgatt tgctcacgga
     1561 gcgtattgcg ccgatgatct atcaatctta tatactgttc acgaaggaag gcagtgtcat
     1621 taatcggctg gattcccgcg ataagctgct ccccttccaa gcggcctcgt atccgccgaa
     1681 gctggaggag agctttcgcg ggcagctcgc cttactcaaa gtcggcgtca gcggcataga
     1741 aggggattcc ttgaatccac tcgttgccgt gaagtcgacc aaaaaccgtc taggctggtc
     1801 gctcgcagcg ttcatcgaag aggattattt ctatcaggac ctgcagagac tgaacaacaa
     1861 ctaccggacc gcgagtatcg tatggatcat tatgcttctg atcagcgcat atctgctcag
     1921 ccgatcgttc acgcatccga ttcgccgatt tgtcgagaag atggaccgtc ttaacaactt
     1981 tgaggtcgtg gcgaagctgc ctgtcacgag aatggacgaa atcggcaggc taacgcagag
     2041 ctacaatgcc atgctcgaga ggattcagag cttgctcctg aagacgaaaa gtgcggagga
     2101 gcagaagaag gaatacgagc tgaagatgct gcgaagccag attgcgcccc attttctgta
     2161 caataccctt gcctgcataa gcagcttggc aaagcagcag cgtatcgacg agcttcgcga
     2221 tacgattcgt tcgctggtca agctgttaag cttcagcttc gacaagcaat cggaatacgt
     2281 atcgcttgag gaggagctgg aagggctgcg aatgtacatg catattcagc aggtgcgcta
     2341 tggggaacaa tatcagttta ggattgatat caatcctgac cttctgcagt atcgcatact
     2401 taagcttacg ctgcagccgc tcgtagaaaa tgcactcttc catggactaa cgccaaatca
     2461 cggcgggctt atcatcgtga aaggcgggct gatgaagggg attctgagac tctatgtgcg
     2521 cgataacggg ataggcatca agcgggagaa gcggagcagg ctgctgttgg aaaatcagga
     2581 tggtgggcag cgctccatgt accggtttac gggcatcggg ctgcggaacg tgcatgagcg
     2641 gattcggatc catcacggcg agacgtacgg cttgcggatc ggaggcgcgg aaggggccgg
     2701 aactgttgtc cgcgtcgata tgcccgtcct gaaggaatac gacgaacgat taggtatttg
     2761 gcgttaacca aaaacgatac ccaggctgtc acgtggtttc ttcagaccat tcgtgacagc
     2821 ctttactatt aatcgttgat agattcgttt accgtatggc gagatttttg ccagaaggcg
     2881 tccctgatca gattcagtcg ctggcggccg caagctttca gcaaattgct gagttcggcg
     2941 ttacaacaat aaccatcaac tcatttcaat tacaaattat ggatattgat gcagatgaat
     3001 caaatttcga ggctaatgat tatgaacgaa atgcgtacat tttttacgtt tctgtgtata
     3061 tcgaggaggc gtcaggacct ttatacttac cttaatggaa gcgcattcaa actatggagg
     3121 gatacaatgg aagccaatca tagcctaacg ccagcccctc ggatacggcc ttctccgcgg
     3181 acaaagctgc tcatgatttt aaaattggca tggcggttta aagcctttta cgtcatgctg
     3241 ctgcccggca ttatttattt tgtcatattt cggtacttcc cgatgtacgg agtcattatc
     3301 gccttcaaag attttgcgat cctggacggc ataacgggca gctcgtgggt cgatccgtgg
     3361 tataagcatt ttcagagctt ttacgagtcg ccttacttca gccagctgtt gaccaataca
     3421 ctgttgatca gcctctacaa actgttatgg gggacgctgc caccgatcat gctggccgtg
     3481 ctgctgaacg aatgccgcgt tcgctggctg aagtcgatcg tacaaacgct gacttacatg
     3541 ccgcacttct tgtcttgggt tattattttc ggcattcttt tgacactctt ctcccagaac
     3601 ggcggtctta taaaccgctg gattgtggaa gcggggggaa gctcgatccc gtttttgacc
     3661 tcgacggaat atttccgcag catactggtc ggatcggagg tatggcaaaa tctcggctgg
     3721 ggtgcgatta tctatttagc cgcgatggcg ggcatcgatc cgacacttta cgaggcggcg
     3781 aaggtggatg gtgccagccg tatgcgaatg atttggcata ttacgcttcc tggcattaga
     3841 agcattatcg tcctgctgtt cgttctgaag cttggccatc tgcttgacgc aggctttgat
     3901 caaatttata ttctgtacaa tattcaggta tacccggttg cggacatcat cgacacatgg
     3961 gtttaccgaa caggtctgca gcagcttaat ttcagcttgg catcggcagt cggattgttc
     4021 aaatcggtga tcggactcat ccttgtgcta ggtgctaatc gcgtggcgaa gaaatggggt
     4081 gagggcatat ggtaagaggc ctcgatgata aaatttttaa cacaatcata tacgtcatac
     4141 tcggaatatg cggacttgtc gccattctgc cgatccttta tgtcgtgtcc gtatccatca
     4201 ctccgttcgg agaagtgctg cgcaacggcg gattcatatt gttcccgaag gaaattacgt
     4261 tttccgctta ccgcacgctg ctgacggagt ccaatattcc gaaggcgttc caaattaccg
     4321 ttctcattac ggtgatcgga acagcggtca atctcgtctt gacgggactg atggcgtacc
     4381 cgctcagccg ccggaatttg ccgggaagaa acttttttct gctcatgatc gtatttacct
     4441 tgttgttcag cggagggctt attccgacct atctggtcgt taagtcgatg gggctgctcg
     4501 attctatctg ggcgatgatt ctgccaaatg cagtctggag ctttaacgtt cttattatga
     4561 aaagcttttt tgaagggctg ccggaggagc tgtttgagtc ggcccgaatg gatggagcca
     4621 aagagttccg tatcctgctg caaatcgtta cgccgctttc cgttcctgtc ttgttgacgg
     4681 ttggattgtt ttacctggtc ggccattgga acgagttttt tcaagcgatt ttttatgtga
     4741 ccgatcgcac gctgtatccg ctgcaggtcg tcgtccggga aattctgatg caaagccagc
     4801 agccgctaga gaacgcagaa aatatgatgc cgacgcaaac gatgcaaatg gcatccgtca
     4861 tgattgcgag cttgccggtc atcgtgatct atccgtttct tcaaaagcat tttacaaaag
     4921 ggatgctgct tggttcgatt aaaggttgac cgatgaaacc attcagagag gggttaagat
     4981 catgaagaaa ttagggactt tgctagtagc cgtttcatta gcgggggcca tgctttctgc
     5041 ttgttcgggg ggaaacagca gcgagaatcc gggaaaccct tcgggcgcta ccgccaagcc
     5101 cggaacggaa acgatggagc agcctaacgg caaaccggtt aagctcgaca ttatcgagac
     5161 ggggaacaat cttccgacgc ccgataaaga tataattaag caggaattgg ataaggcgct
     5221 gaatatcgac ctgaacctga cagtgtatcc agcagcggac gattacaaca atcaactaaa
     5281 cgttcggatg tcttcgggga actttcccga cctgttcatg gtcgaccggc agcagctcat
     5341 tcaattttcc aagcaagggc tgcttctcga tctgacgccg tatatggata aattggagca
     5401 aacggtagcg ttcatcggag tggacagcgt caagaagggg atggtcgacg ggaaagtata
     5461 tggcatctcc aaatctccgc aaatccctta caacacctta tggatccgaa aggattggct
     5521 cgacaagctg aagctggagg tgccgacgac cgtagagcag ttggcttccg tagcggaagc
     5581 gttcactaag aatgatccgg atggaaatgg caagccggac accttcggtc tgacgggcag
     5641 caagctgagt gcattctcga ccgttttcgg agccttcggc gtcggaatgc caggcaactt
     5701 ctacgagaag gacggtaaag tcgtcagtgc gctgcatgaa ccggcaatga aggatgcttt
     5761 ggcctttatt aaggacatga ttgaatccgg atcggttgat ccggagctgc tcgccaatag
     5821 cggattgcag catcaagaga aggcgatcaa agggcaggcg ggcatcgtct atatcgattg
     5881 gccgaacatg acgaaggagc agttcgtgga acagattaaa accgttaatc cgaatgcgga
     5941 atggctgcaa atcgccgctc catcgggtac aggaggacaa ttcgacggtt cgtgggatat
     6001 cggtgcagcg cctggtagat atgccattcc gaaagcgctt gagaaagacc cggagaagct
     6061 gcagcgggtg ttcgatctcc tcaactatat ttcgaatccg gacggaggct cgttgctcgt
     6121 gcagttcggg gtgaaggata cacacttcac acttgaggac ggcaagccgt tgatgacgga
     6181 caaagcgggc gaggttggcc attcttggct gtaccaattc accggcagac cggaaatgga
     6241 atatttgcaa gcgaagttcg ccgcacaatc ggctgcaatc gaattcgcga acgatcaacc
     6301 ccgtattgaa gcgttgaacg gattcgtcga caatccggag gggtataacc ctgccgatgc
     6361 gactcgatac atggaagagg agatcgcgaa gtttatttac gataaacgtc cattgaccga
     6421 atacgatgac tttatcaaga cgctggaaac gtctatgaac tacaaagcgt tagtggacag
     6481 cgctatggat cagctcaagg cgctcggtta cggggactaa ataacgggaa tgaaaggccg
     6541 acctcattcg atgcaggtcg gtcttttcta tcatacgcta tgagtttttc ggtacaacga
     6601 aggattgacc ccgcacagtt ttttgaagct cttgcttaaa tgatgttcgt cggtaaatcc
     6661 gcaatgctcg gcgatttggg caagggtaag cgaagagtat acaaggagct gcttcacctt
     6721 gtccattcta agattagttg cgtaggcgct tggcgttatg cggaactcgc gtgtaaacag
     6781 tcttgtcagc tgcacctggg ttagaccaag ctccacagcg atcgacttca acgaaaggcc
     6841 gaattctgct tgctgctgaa gcagatgcag ggctcggcca agggtcggat cctcgctgaa
     6901 caaggtcatc gtatgctgct cggattgctc gatctgaagc aaatagagca gatccctgag
     6961 aagatgtttc ttgtacatat gaccaatccc tgcatgcaag tattgggctt cgcgaaattg
     7021 agaaagggtg gattggaagc gtttgttgtt caacagccga agcttgccga aagtcgggaa
     7081 atccgccaca cgcggcggct cctctaggga attgatccat tgaaacccca taagatggaa
     7141 cgataaaccg tccgtttgcc ggtaaaaagt tagatcgggc gggcataata cgatgtcatc
     7201 cttgaccgcc cttccgcttt ggctgcccat tctgtaatta aaagcgcctt cttcgacgat
     7261 gaacaacgtc caatgatcat acgtatcatg cgttttctga aattgagggg tatccttcac
     7321 gtagacatgg tattgcagat cgggttccag aaatcgactg aactccattg catgacaacc
     7381 ccctttcgta agttgaaatt atttacaagg aaaatcattt tttcttacat tataacatga
     7441 tggtttgcca aatataatta aattaaatac aagtaggagg tataaaggat gaagacagcc
     7501 aagttggaaa taccgaaatt aatggagcaa tttcatgaac aggggtattt ggttatacca
     7561 gatattttgt cgcaggaaca ggtgagccgg ctgaatgccg cgatcgacga aattgtcttg
     7621 gcggaaccag aaacgctttc gcataatatt tataacagcg tagaacgcca tgccgagatc
     7681 gctgcattaa tcgatcagcc tgccattctt ccgttaatcg ttaatttgct tggccacaac
     7741 attcagcttc acatctccca cctcacgatc agacaaccga atccaagcga agcccaaacg
     7801 gccacgcaca gctttatcga ttggcatcaa gacggtccgc atccgcaatt tcctgtcatt
     7861 aacggcatga cggcaaccta ttatattaag gtttgttata ttttgagcga tatgtcggag
     7921 ccggatcgcg gcaatacgaa agtgattccg ggcagtcaca agcagccgta caacccgaat
     7981 cacaaggatg tgcgccagca gcttgacgga gaggtacaag tgtgcggaaa accaggtgac
     8041 gtcttcgtgt tcgcccaaaa cttgtggcat gctggctctc cgaatcgctc cgcattcaca
     8101 agaaggcagc tgttcctcgg ctacagcccg atctggatgc gtcctatcga ctatcattcg
     8161 gcgtctgtga gcctgttgaa ggacgccgat ccgatacgcc gccagctgct tgggcagatc
     8221 agcgacaaca aattcaatta ttacgttccg gaggattcga tggtgcctct caaatccatg
     8281 ttgatccatc catcctcgca gtagcctcgc agtagctatc accatccgtt cgaatgggct
     8341 actgattgat catggtaagg tgctgctgtt gattggcgaa aacgtccagt caaattgagg
     8401 ctgcggtgcg taaagtgacg gggggctgcc tattatcggc tgtgaaggtc tggccgaggc
     8461 agtgtcgcag gcgcacaagc tggcctcgcc gtaaatttga agagcgcggg cgtcactttg
     8521 tagaactggt cggggcgcag ctccggtcag agggaaaaga ttaaacaaga tatgagggtt
     8581 cgctgggaga acctttttgc cctgatgtat tttcatttat agattgttct taaagggaac
     8641 cgatcgaatc attcattacg ctaattggga acgatagttg aaaatagcaa ggagcagttt
     8701 gccggctggc agctgctcct tttctttaag ctaacgggca gtttagtgga atattttatc
     8761 catttatggt tgatgaattt catgctagag taaattttta aatgtgtacg aaagcaggac
     8821 tgtaataact gacttattac aatctaattg acgacttcaa ttaaattttc aaaaaggaag
     8881 aacactttgc ccaagcacat aaagatctac gcactaatac ttattatttt catattaata
     8941 aacgctgcga tgtacagaca tttggaaaac caatcatgcg taaaatacaa tgacctctat
     9001 tcactatatc agcagaagaa cgactcggca tttgtctatt tagtaaagca cgcttctgaa
     9061 acgattccgc ttgctgacac cttaatggca attagtgagt cgaaggaaaa tgaagatcct
     9121 gctaagattc ggcaattgat cgataaggcg aagatccaag cggaagaaat cgataatcaa
     9181 atatcaatat tcattgaatt tagcgatacc tacagtaaca atgctgttcc taagcatttt
     9241 gttaataatg cggcaatgac aacggatgag cagctggaca tgtttattct tgctcgtgag
     9301 gcgagaatat ggtggtcatt atacgatata agctattcgt attggaagtc taatcctaaa
     9361 acgataggca ccaagactag agaaaccttg cgctcgcttg caacggagct ctatgagcta
     9421 aataagacga ttacgtcgtt taaagataac gacgcagctc acatgtttta tctagcggag
     9481 aattataaag cgttgatgct agggaagttg aaaccacacc ttgaaagact gaaaaagatc
     9541 caagatcatt tttcaggaca taaataagtg gaatgcgtgg aatgagttca tcaggaacct
     9601 atcggaagta gacctcattg ccgaaaagct ctgtaagtga agaaatccct gatgttcatc
     9661 tttgtataat cggagaagag gatgattttg tactggcttc tccctttaga tgattaagtt
     9721 aagcgatata aaatacctaa taataatgtt acattcgtat ggatttaatg aatgaatcct
     9781 aaaataaaat tcgatccatg ttagaatatc tcaccagccg ttgagtagat tggcagccat
     9841 ttttttgtga agtatgacct ttagatgccc aatctttatg tggattcata agggtgtttt
     9901 ttcaacaaat ccgttactgt gggatacttt ttggttaaaa tgcggtagag tatgttatta
     9961 tcgcagtaaa gcaatacgtc atttaaagct gagatactat ttggagggag cactcattaa
    10021 taacatcgca atgaaagaag caatgtccat gttaaagaaa acgagccgca ctttttttat
    10081 accaataagt tatttggatt caggattaag ggaagctgtt gcatcaggct atttatgtat
    10141 gcgggccata gatgaaatcg aggaccacaa tgaactcgct gacgaactga aggtggaact
    10201 acttcttgag atttatgaaa catttaaaac tcaggatgtt atggaaaccc aattcatact
    10261 atctcctcat cggacggtat taccagcagt tacgatgcaa ataggtaaat gggcgcttct
    10321 atgtccgtct tccagtgccg atatcgtata tcggtacatc tcaaagatgg cgttacatat
    10381 ggctgaatgg gttcaaaacg ggtggagcat tcatacagaa gaggatctgg accgatatac
    10441 ctatagcgtg gcaggtatgg ttggagagat gttatcggag ctttggtatt ggtatgacgg
    10501 aactcgatca gatctaacga aagcgattgc tttcggacga ggtctacaag cggtaaatat
    10561 cctccgtaat agagaagagg atcttaaacg tggcgttgac ttctttcctg atggttgggg
    10621 atataaggag atgcaacagt acacacaccg caatctacag attgccgact cttatatcgc
    10681 agagctgaag gatggcccag cattaaagtt ttgcaagatt ccattagcgt tagcccatgc
    10741 tacagtcaac ctcatcgctt caggtggaaa taaattaacg agggatgcgg ttctaaaaat
    10801 tgtgaatcgt gtgactggat aaatttaatt gtccatattt attactgttc atcgtttgtc
    10861 gggcgatacg atcatggtcc cattgaaagt cgctaattta gcggcttttt tgttttatcg
    10921 gtacaagttc agcgatgtcc gggcaatatt accgcatttg ggagcattac ctgatcctgg
    10981 cactcattta ttttttctca cctacagcct cagcaagcag ctgaattatg cgcccaagcc
    11041 agtcaaagtt tccttcatta ttggacagca gagaactttc gggagatttc ccgatatgct
    11101 gttggtgaca tgcctttttt agccgtaaat tgtttaatga agtaagtgtc atactcaaat
    11161 ccggtagcac gtgcaatttc atttaaggtc atgtctgtat gggtcagaag attccccgca
    11221 accttcaagc ggtgcgacag taagtaaccc attgcggtgc acccgcatct ttcctgaaac
    11281 atcttattga gcgaaacgcg gtttaagtac gcgcattttg ttaaatcttc cagggtgatt
    11341 ttgtccggat aatttgtgtg tatatattcc agaactaaat ccacaggtga ctgttcgctg
    11401 tgacggttta agtcttcaag cacccccatt atttgtataa aatatttttt tattctacat
    11461 gcccagagtg catcgctttg cgcatacact tctgtgccaa gcacaaaaaa ccactcgaat
    11521 aattgtggat atgccttctc ggttatgcga ggtatccccg ttcgttcagg agacttacga
    11581 aacagcgaaa gacctgtttc tattttcata tcggtcggaa aataagtttg tgtttcagaa
    11641 tggggggtcg agttaagaaa atccggatga aaactaaatg atgatgcaga agcgttattc
    11701 ttatctaaaa cttgtatcgt atcctcttca gacaaacaaa gaatagcggg tgctgaaatg
    11761 gtgatcgggc gttcgttcaa tatccctttt atacttccat tcgtaacaaa aacaagcgta
    11821 aaccgctccg ggtaggggaa atgtgcaaaa tcttcggcag ctacaaattc gatatctacc
    11881 gttctgtttt tatggcgatc aatttgtggc atggttctca cctgacaaat agtatagtta
    11941 aatgcttcac atataacagt gtatcacaaa atttcaaggg atataatttg gatattgaca
    12001 gaaaggtggt tatgatgatg gcaattaaca tcgcaattaa cggttttggc agaattggca
    12061 gacttgcatt tcggcagctt tttgatacag aaggatatag agttgcagcc atcaatgatc
    12121 ttacaagtcc gcagatgctt gcgcacttgc tgaagcatga caccacgcaa gggcgttatg
    12181 atgccaagat tggttataac gaaaacagct tgaacgtgaa cggtgtggat attccgatct
    12241 atgccgaaaa agacccagga aagctcccgt ggaaagaact gcaaattgac gttgttctgg
    12301 aatgcactgg cttcttcgca tcgaaaaaag cgtcagcagc acatattgaa gcaggtgcca
    12361 aaaaggtgct gatctccacc acagccggga aggatgttcc cactattgtt ttcggtatca
    12421 atgaacatac gttggctaag aacgatacca ttgtttcggc agcttcctgt acgacgaact
    12481 gcctcgcgcc aatggcgtat ttcttgaacg agcttgcacc actcaaaaag ggctttatga
    12541 ccaccataca cgcttacaca aacgaccaga acaccttgga tggcccccat cccaagatcg
    12601 acctgcggcg ggcgcgttct gcggcgggca acatcatccc gacctcgacc ggagcagcaa
    12661 aagcaatcgg gctagtgatc ccgtccttgg atggcaagct ggatggaaca tcgcaaagag
    12721 tgccgttcat ggcgggctca ctgacagaat taaccgcagt ggtaggcggc tccgtgacag
    12781 tagagtaggt caacaagaag atggaacagt cccagtcaaa agaatatggg tatacagatg
    12841 aacagcttgt ttcgtctgat attatcggca tgacttacgg cagtttgttt gacgccacac
    12901 agacaaaggt aacagagcta ggaacagata cattagtgaa aattgctgcg tggtatgata
    12961 acgagaactc ctttaccagc cagttaatac gcaccgcaaa atacctagca aaattataag
    13021 gttttacggg aaaaggggct gtccgcaaat tgttcgcatg acttgggaac ataacataac
    13081 atcgaaaaca tagaaatatt tcaacaaata aagaatggga gagagcttgc cattctttat
    13141 ttttatattt gcctttcatc caaagattac atgactaatc catgataaaa tattaggaga
    13201 ctatactcgg taaaagtttt attaggagtt gagaacagca tgaattacta caaaggagca
    13261 gtacctggat cagataactt catttatttt aaaagcgaag tcaaattgaa ggaaagtgat
    13321 gttgtggttt tagatgataa gaagtacttc attgagagta tcgataacgg attgttgatt
    13381 cttcagaggg ttggatcaat tatatcagtg agtgtgtaaa taggcataca gctatgaact
    13441 atgcaatgga gtacagaaat cttggctcta tcgaacctac tgattaaagt tttattattt
    13501 gagatgatca ataggtgttt atgtcattcg tgagttagcc gtgaatgaaa tcaagggctt
    13561 gccaagagac cacaattatc aattgcttcg aattccgcta aatcataact tcacatatta
    13621 tcacaaaaag agtggtaagt tggttgggat gaatgcggtt gatcatgagc attttcatat
    13681 caaagatggg agagacatgc ataagttcat tttgattaga caccgaaccg gtgagtggcc
    13741 atctataaaa tgcagaaaaa cgggccgaaa ttataccttt cagcccgttt tttgctcatc
    13801 atttcaaagt ataatgtaaa tcacgaatct attttcctgc taagctcctt ccaccatatc
    13861 ccgtctgcga tatcccaaat agcccataat catcaaagca acactgatca ctgagatcgt
    13921 aataaaggtt gctgcatcaa acgaatctac cggcatccgc ggaatccaac tttgaacggc
    13981 tgttttcgag aaccattccg gcaaatcgag aatgccgccg aaatagttta atgcaaaaga
    14041 atagccaaga tacgcatata cggctttgcc tagtcttggt gcccaaccta aagccaaagc
    14101 ggcaagtgca ataaagaaca acacggaagg caggaagtta tagccagcgg ccaaaaaatc
    14161 cctcatattc atggacgagc cgtcacccag ggcagaaatg gccgtcccgc caagtccgct
    14221 tgaagctagc aaaatgccaa cgattccagc aacaatcgcc aaaatgacac tcgtccaata
    14281 gagctgagct cgagtcactt ttgttgcata aagctggctt aaatgctgtc gcgcttcttc
    14341 cgagaaaagt ttgttcacga tcgcaatcgg caaaatggaa accaatccaa tcatgaccat
    14401 cataatggtc ccggtgaagg cttcttcgat ggaaacgccg gatatcgtaa acatttgact
    14461 catgatttca ttgctttcaa ggaacgtctg catatctcca taaatcgaac cataggctgc
    14521 tcccatgacg acgaaagcaa tcaaccaact gatcattacg cctttgttca gctttgtaaa
    14581 caggccgggt acggacagca atgatttttt tgccgactcc cggccatctc tttctggtaa
    14641 ataaccggca cccatatctc gaccgccttc aaggacaaaa gcgatgatca cgacaataac
    14701 gctgaagact atagccaaga tcagggggac cccattgttt tctgtaaatg gataagtcag
    14761 ataagtccaa cccatcggat tgatcatgga aaaatcaaca ttcgacacat ccgttccggc
    14821 tcggacaata tagagcaagc ctacaattcc gagcgatgaa ccggttgcac cggatgaagt
    14881 cggcataatt tgcgccataa ctaaggcaat tacggctccc aagatcccgg ccattccaat
    14941 ggatgcgcca aacaaaaagg atccttcggc cgaaatcgta tctacgccaa agctagtcat
    15001 cattccgcca ataacgagcg ctaatagaat attgatcatg acgacttcgg caatcaccgc
    15061 aagcgaattg gcttgacggc ctacttgaaa agagcgtacg agttcagtaa gcccaagatc
    15121 ttcttctttg cgagtatggc ttaccacatg caaagcagcg ataatcatcg caaacaaacc
    15181 gcagaataac aacatttcgt gcgcatacat tgcacccaaa gtataatcag ctgcgttctc
    15241 aatcggtgta ggaccaacca tggaaatcat agcaggattt tgcaaggttt catacattcc
    15301 ctgcaaccct tggcccttgc ccatttcttc aaaagccgga acaaatccgg ctgaaaacaa
    15361 gcctaaacct aaaacccaga tgatgatttt tttccaatca cgtttcaggt attggacgaa
    15421 tagtactcgc gaacgcgcaa atttttcctg cattataatc tcctccgttt ccgctcttag
    15481 acttcataat gacgcatgaa taagtcttct agcgtaggcg gcacggactc aaacttcttg
    15541 acccccaatt ttgccgcttc ggacaaaatc tcattgataa attcgttatc cgcaaagaat
    15601 gtcgcttgat tgccggattg cttgaaatca tgaacaccgt taacggatgc cattatagcc
    15661 acattgcctt gcgttactat agttactgta gaacgcgtta aatgacgcag ctcatccaat
    15721 gttccggttt caaccacttt gccttggcga atgataacta ctttatcggc cagtcgttcc
    15781 acttcgctta aaatatgaga ggacaacaag atggcttttc ccgcaagctt gattttttcg
    15841 acctcatcct ggaagacggc ttccattaac ggatcaaggc cggaagtcgg ttcgtcgaaa
    15901 atatacaaat cggagtcaac ggataaagcc gcgatcaagc cgactttttg ccgatttcct
    15961 ttggaatagc ctttggcttt cttcttagga tccaattcaa accgtttaat caaatagtcg
    16021 cgtttatttt tgtctccgcc gccatgcaat ttcataaata aatcaatgat ttcgccgcct
    16081 gttaagctgc cccaaagagc cacgtcccca ggtacataag aaattcgttt atgaatctca
    16141 aggctatctt tccatacatc cttgccgaag atttttgcat ctccggcatc ccgatggatg
    16201 attccgagca aaatgcgaat cgttgtggat ttccccgcgc cattcggtcc gataaagccg
    16261 actacttccc cggcatttac cgcaaatgac acgtcatgca gcgctttaaa tttcccgaat
    16321 cttttttgca agccttgcac ttctacaatg tttgtcatag cactaaaact ccttctagac
    16381 cagttttagt aacgtgcttt ccagtttaaa gcaaagctga taaatagcga actaataatc
    16441 gatatagagt tcgtaagttc tgactattta ctttgtttta aaccaaagtt catttacaat
    16501 ttcagttata cacccgatta tccgcatagt caacgcaaaa atatataagt ttagaactaa
    16561 tgtatgtttg ataattcata attatcgcta tataataaat aggaagggaa aatacgaact
    16621 aaatccttct taaaatattt ttttagtcat actaagttag aaagcaggaa taaggaatga
    16681 acggctttga aaagaggacg caagagaaga agaatcaagt tctagaagca acttttaaat
    16741 tgattaatac cgaaatcggc atcgaaaatg taacagtcgc tgagattgct agacatgcca
    16801 atgtcggtaa aacgacgatt tttaagtatt ttgggagcaa agaaaacctg gtccatgagg
    16861 tttttaagta ttttttaact caaatggggg aaaccgcccg agaaatcatg gccgaaaata
    16921 aacctttcga agaaacgatc attgctatga gtcagaacaa aatcaattat ctaaaaaaaa
    16981 tcaacaaaca attttatttg tatttaatgg attattttac aaagaaagat gatgatggat
    17041 tatctctgat gatgcagcaa tacgtcaagg aaagctacag tcttatgttg gatttgtttc
    17101 accgcgggcg taaagaaggc aaggttgatc tgaaatattc ggatgaattt cttctgattt
    17161 atttccaggc cctggttgaa gggatctcca gcccgcatat ctacccaaag attctcccat
    17221 ataccgcaca atggacggaa ttgctgataa aaggtattgc gccaagcaaa taaagcacat
    17281 attccagttt ttccttactg gcttatttgg taacgttaat ggcattatga ccgagccact
    17341 gaatgagttg gaaatcaaac tcactgaaac acttttatac attcctgaga acattttgct
    17401 taaaatatat ctgaatgtgc taaagggcga gtcattcccc ttaatcaagg acatcttacg
    17461 ccgaatgagg gttgatggat atctccgacc tgatattgac gacgacctga ttttttttat
    17521 gtttgagtca atgcagttta atttagtcct gttttttagg gaattcgata ttaaagactc
    17581 taagctgcaa cataagatta gcaagtactt tgctgacttt atgggtcatg ggctgcttga
    17641 agatcataaa cattctgaaa ttgttagcga tctcaagaaa gccaaggagt agatatgatt
    17701 tactgtattt cacattcgcc acttttatta attaaggggg aagaagaaaa tgaaaacttt
    17761 tgaagcattt ccagaaccaa tcggcagcta tactgtcggt cgaacccaga tggattttga
    17821 gtatacggca tcagatcatt taaaaagaga actgacggcg tttgtgtact atccgtccga
    17881 cagtagcgaa ggtaagacta catcaacgta catgtttcct gaagtttacg aaatgcttga
    17941 tgagcagcca cttctcactg cgttgaagga tgcttactcc atagatatca agacccagtg
    18001 ttacgacgac cttgctctct ccgggaagga aaagcgctat ccggtgttat tctatgtttg
    18061 cggcgggggc ggttctccag aatggggtac cgtgatcagt acagacttgg caagtttggg
    18121 atatgtcgtg gtaagcatcg gccatcagaa tagcacgatg tataagcgta aggatgggcg
    18181 cctgtttaat gtatcaaagg gtttttcgga tgtcattatg gcgttttctg aagatccgga
    18241 gatggtggcg ttggctggta agatggagat gcggcctgac gatgaaactg ccatcgagat
    18301 gtgccacaag gtgcttacac tgccggtact tgccaagata acagagtata gtgaattaca
    18361 ggcagaggat gtaaggtatg tagccgatta tctttacaaa atggactctg gagagctgaa
    18421 ttccatcttc aagggcagat tgttgcttga catcggcatg ggcatagtcg gacattctta
    18481 tggagggcct acgacggcga ttgtttgtcg ggacgacgac cggtttgcct gcgggattgg
    18541 cctggatagc gctgcgttcg gccttcaggg cagcgacctt aataaaccct tcttgctgct
    18601 ttattgtgaa cctaactata acatgaatgc gataattggc gctaacaata gcatgcaaac
    18661 ctattatttc tctgttgatc gtgttgcgca tttagattac tgcgacatcg tgtttaccag
    18721 tgttaatgag gaactcagag gcgaacggga tgctatggag atgcgaaatc ttgttacaga
    18781 ctatacgaag aacttttttg atcaatacat actgcagaag gctgcaagtg tggaaagtct
    18841 ggcatacgat ggcgtggact tggtcaagaa gaccagcaac aagtgacata accgagaggt
    18901 tgctgataaa cgcatgtcaa agagctagcc gtacagatac agagccgata accctattac
    18961 gcggttatcg gctctctcat ttttcaggca ttgttttcta tttgagatga taagcggtgt
    19021 tttcccataa tcagctgctt tttgtgcaac tagcaggaag ggttacacaa tagaataata
    19081 gaatttttta tatgggattt tatgttacaa tcacttattt actatggaga ggagagttac
    19141 aacaatgaag cgctttattt tagtattggt aagcgttata tcgatattac ttactgcttg
    19201 ttctagtcca accagttgat ctaacgaata cactagagaa atatgctgta cccgttaatc
    19261 aattgacaat acccgatggt gtccaaataa ttggtttagg cgaagcaact cataacaacg
    19321 gtgaatttca gtctgtacgg cttgatgtat ttaaggtgct tgttgaaaag tatggtgttc
    19381 gaacattcgt attagaagag gattttgcta attcagaatt aatgaatcgg tatctatcgg
    19441 gcgaggatat cgagctgcaa gaagcatggg aaaaatggtt tcccttctac catacacaag
    19501 aaatggctga attattttga gtggatgcga gaatataacc gttccgcatc tagtgaagaa
    19561 cagcttcaat attggggcat ggatgttcag cgatcagaac tgatgatacc tacacttgat
    19621 aattatttaa aagtggtgga tcgtgaactc tctaaagagc ttaaccgttt acaggtcggc
    19681 agtagtgacc tgtgggaaat atcgaatcag ttactcggca atatctttac tccaaacagt
    19741 gagcgtgcat ggactaaaag tgattataaa cagctgcaac gacaatggag tccactaatc
    19801 caaaaggata ttcagcttat tgaacgattg atacaccgga tgacgatgaa tgctgatctt
    19861 cttatcgcca aatcagatga acaaatgtat gaggccgcaa tgcagaatat ccagtctatt
    19921 tatgttacct actcagtgat gaatgactct ttgcttcgag attttagcga gggaaatggg
    19981 tatcttcact ttgtttcttc cgcaaaccat cgtgataaag ccatgaagga aaaggtagac
    20041 tggattttaa accaggcgaa tggacccatt ctaattgcag gtcataatgg tcatatttcg
    20101 aaaaagaata gagctgccgc tgattgtttt gttaatgcag caaaagagca aaatattaat
    20161 gtagatagca aaatgattaa acttacatat ataggtgagc ttctggagga aagttatggc
    20221 gatgcttatt atgctatcgg aacatccttt aatgagggcg tattagcagc agactcaaag
    20281 attataacgg atccaaatcc gcctaccttc actattcata gtgataattt attactaaat
    20341 tcattgaagg atttgccggc ggatcgttat ttcttggatt ttgatcgtgc gaagcaagat
    20401 gagcaattaa accggctaat ctccaaggat gagttaaaga tgccatatgt aggtagcctg
    20461 aatggtgttg atttgaatga tccaaatcat cgtaagatag aaaactacta ttcaggcatg
    20521 attttagatg agtcatttga tgcattaatt cattttcgca aggtaaacgt attcacacct
    20581 tatgaaaggt aattaataaa aatggaaaaa tcagcttcaa ttaataaccc gtagctattg
    20641 tcgaggaaca agaacatggt accattcaaa gtcgctaatt tagcggcttt tttgttttat
    20701 tggtacaagt tcttgtccca agccaaggac aagaacttgt accgattgcc gaaagggaca
    20761 cgaacttaat ccgtttaccg atgaatacat atctaattaa aattctgcag ctatttcatt
    20821 aa
//
