LOCUS NZ_JAFKPO010000004 20354 bp DNA linear CON 15-DEC-2024 DEFINITION Bacteroides fragilis strain FSHXHZ1E1 Scaffold4, whole genome shotgun sequence. ACCESSION NZ_JAFKPO010000004 VERSION NZ_JAFKPO010000004.1 KEYWORDS WGS; RefSeq. SOURCE Bacteroides fragilis ORGANISM Bacteroides fragilis Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides. REFERENCE 1 (bases 1 to 554837) AUTHORS Wang,C., Li,S., Hong,K., Yu,L., Tian,F., Zhao,J., Zhang,H., Chen,W. and Zhai,Q. TITLE The roles of different Bacteroides fragilis strains in protecting against DSS-induced ulcerative colitis and related functional genes JOURNAL Food Funct (2021) In press PUBMED 34308455 REMARK Publication Status: Available-Online prior to print REFERENCE 2 (bases 1 to 554837) AUTHORS Wang,C. TITLE Direct Submission JOURNAL Submitted (01-MAR-2021) School of Food Science and Technology, Jiangnan University, 1800th Lihu Avenue, Wuxi, Jiangsu 214122, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: FALCON v. 2.3 OR MAY-2011 Genome Representation :: Full Expected Final Version :: No Genome Coverage :: 12x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_019633825.1-RS_2024_12_15 Annotation Date :: 12/15/2024 11:10:07 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.9 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 3,946 CDSs (total) :: 3,876 Genes (coding) :: 3,807 CDSs (with protein) :: 3,807 Genes (RNA) :: 70 rRNAs :: 3, 1, 1 (5S, 16S, 23S) complete rRNAs :: 3, 1, 1 (5S, 16S, 23S) tRNAs :: 63 ncRNAs :: 2 Pseudo Genes (total) :: 69 CDSs (without protein) :: 69 Pseudo Genes (ambiguous residues) :: 0 of 69 Pseudo Genes (frameshifted) :: 26 of 69 Pseudo Genes (incomplete) :: 50 of 69 Pseudo Genes (internal stop) :: 15 of 69 Pseudo Genes (multiple problems) :: 19 of 69 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 16:57:18 NOTE :: This is a single region extracted from a larger record! Orig. start :: 16334 Orig. end :: 36688 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to JAFKPO010000004.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..20354 /candidate_cluster_numbers="1" /contig_edge="False" /product="RRE-containing" /region_number="1" /rules="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /tool="antismash" cand_cluster 1..20354 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /kind="single" /product="RRE-containing" /protoclusters="1" /tool="antismash" protocluster 1..20354 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[10000:10354](-)" /cutoff="10000" /detection_rule="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /neighbourhood="10000" /product="RRE-containing" /protocluster_number="1" /tool="antismash" proto_core complement(10001..10354) /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])" /neighbourhood="10000" /product="RRE-containing" /protocluster_number="1" misc_feature 84..98 /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: medium, score: 21.9" /tool="antismash" gene 237..1577 /locus_tag="K5L50_RS10655" CDS 237..1577 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005785482.1" /locus_tag="K5L50_RS10655" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="DUF5690 family protein" /protein_id="WP_220654180.1" /transl_table=11 /translation="MDNVQQVKTNSQKKLSDFLFILWAGGAALLSYSLVYALRKPYTAA GFDGLETFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIVLAEASLI LFGLLPAPYNIGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA GLFVMDTLNISEFWMPALIGGIALPILALLGYSLNRLPQPTAEDIAMKSKRETLNGKQR WDIFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTIIILV IFGLMVFVRSNLKALSILLGLIIISMVVMVVVSFGYEQLQLNAIVWLFIQSLCLYLAFL TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTTFYNLMA GYVGVICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY" gene 1621..3132 /locus_tag="K5L50_RS10660" CDS 1621..3132 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011109230.1" /locus_tag="K5L50_RS10660" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase" /protein_id="WP_032539640.1" /transl_table=11 /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI TTPVTVFAGPGNNGGDALAVARMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV KFSEVSTQFVPPTLTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG LMGEENTFNVKANIIRAHLTLSLQLPKLAFLFAENAEFVGEWKLLDINLSHEAIEETES NYALLEAEEIHALIKPRSPFSHKGNFGHALLIAGSYGMAGASVLAARACMRSGVGLLTV HAPMRNNDILQISVPEAIVELDASDSCFAFPTDTDDYQAVGIGPGIGRSEETEAALLEQ LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLTQGYPA EEAAKIGTYVHGLAGDFARKKQGVIGMTAGDIVNYLPMAWRLVSE" gene 3206..4261 /locus_tag="K5L50_RS10665" CDS 3206..4261 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005775831.1" /locus_tag="K5L50_RS10665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="DUF4831 family protein" /protein_id="WP_005775831.1" /transl_table=11 /translation="MKKLIILTGLLLSASAYAQTEVTAGVTRGKDYGVTYALPKTAIDI EVKANKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSDHTYFVKLK DKTVAPLIELTEDGIVKSINVPLSPKKSAPIQPATTLRKKVNPRDFLTEEILMAGSTAK MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD ERIFTIRLNPEKEMDNEVAFRFSRKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK VDGIAYNVPGKAQVTLIEGKKEWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPATG GLIKVDREEGE" gene 4487..5014 /locus_tag="K5L50_RS10670" CDS 4487..5014 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="K5L50_RS10670" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_181996436.1" /transl_table=11 /translation="MKKFLPEADLSKLRTILDIKNSYNCGTLSLEDARKLLKEKVVVLK LYEITFAEQELKGGEENECRKEDIQRMLELFNGIMDTSRPDLPPEYSVMYYYRGNDELR KILPSIEGLVPPPYPTNPEQNQYPVYLVEGLIGGISSFERQDGGDQPQVQTAQVPFGAG YTTQSHHQHDNR" gene complement(5174..6526) /locus_tag="K5L50_RS10675" CDS complement(5174..6526) /EC_number="1.6.5.-" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Pyr_redox_2" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008659319.1" /locus_tag="K5L50_RS10675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="NAD(P)/FAD-dependent oxidoreductase" /protein_id="WP_220654181.1" /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-46, bitscore: 154.1, seeds: 64, tool: rule-based-clusters)" /transl_table=11 /translation="MSFNIARNHNQKRIIIAGGGFGGLKLAGELRKSDYQVILLDRNNY HQFPPLIYQIASSGLEPSSISFPFRRIFRKRKNFYFRMAELRGIYPEKKIIQTSIGKID YDYLVLALGTTSNFFGNSRIEEEAMPMKTVSEAMGLRNALLSNLERSITCSTEQEKQEL QNIVIVGGGATGVEIAGALSEMRKYVIPADYPDMDSSRINIFLIEAAGRLLSGMSAESS ARAEQFLRNMGVNICLHKRVVDYRDHKVILEDGMAIPTRSFIWVSGVKAVPVGNMPAEC IGRGGRIKVDAFNRVEGVENVFAIGDQCIMTADRKYPEGHPQLAQVAIQQGRLLAANLK RMARKKPMRPFGYRDLGSMATVGRNRAVAEFNRVRTQGLMAWVLWLVVHLRSILGVRNK VNVLLNWMWNYFTYDQSLRIIVYARKAKEIREREEREAKAHWGDEMKVPRR" gene complement(6697..7713) /locus_tag="K5L50_RS10680" CDS complement(6697..7713) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004302159.1" /locus_tag="K5L50_RS10680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="inorganic phosphate transporter" /protein_id="WP_220654182.1" /transl_table=11 /translation="MELLVIIIVLALIFDYINGFHDAANSIATIVSTKVLTPFQAVIWA AFFNFLAFFIAKYVIGGFGIANTVSKTVVEPYITLPVILAGVIAAIVWSLFTWWKGIPS SSSHTLIGGFAGAAIMAHGFEAIQLNIILKIAVFIFLAPLIGMVIAFGVTLLVFYICKR AHPHTAEVWFKKLQLVSSAMFSIGHGLNDSQKVMGIIAAAMIAGHSESLGMGINSIDDL PDWVAFSCFTAISLGTMSGGWKIVKTMGTKITKVTPLEGVIAETAGAFTLYLTEYLKIP VSTTHTITGAIIGVGATKRLSAVRWGVTKNLMTAWVLTIPVSGLLAAAVYLIAASFL" gene complement(7727..8374) /locus_tag="K5L50_RS10685" CDS complement(7727..8374) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004302161.1" /locus_tag="K5L50_RS10685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="DUF47 domain-containing protein" /protein_id="WP_122142850.1" /transl_table=11 /translation="MKNSFFSRFTPKEPKFFPLLKQLSEILTASSELLVEGMKHDSPEK RAIFYKRIKDMEREGDKLTHRILDELGTTFITPFDREDIHDLASGIDDVIDGINSCAKR IAIYNPHPISESGKELSRMIQQEAEYIVKAMDELETFRQNPNTLRGYCSKMHDIENHAD DVYELFITKLFEEEKDCIELIKIKEIVYELEKTTDAAEHVGKILRSLIVKYA" gene complement(8393..9043) /locus_tag="K5L50_RS10690" CDS complement(8393..9043) /codon_start=1 /gene_functions="other (smcogs) SMCOG1188: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005930866.1" /locus_tag="K5L50_RS10690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="DedA family protein" /protein_id="WP_122142851.1" /transl_table=11 /translation="MDFLLDFILHVDQYMIDIVQEYHTWAYVILFLIIFCETGLVVTPF LPGDSLLFVAGAIAALPDMLVEVNVLVLILFAAAVLGDSCNYMIGYFFGRKLFRNPDSR IFKQSHLEKTHEFYKKYGGKTIILARFVPIVRTFAPFVAGMGKMHYYYFMLYNLTGGVL WVAIFCYAGYFFGDLPFVQKNLKLLIVAIIVVSVLPAVIEVIRARLKTRKQTK" gene complement(10001..10354) /locus_tag="K5L50_RS10695" CDS complement(10001..10354) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RRE-containing: PqqD_RRE" /gene_functions="biosynthetic-additional (rule-based-clusters) PF05402" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005818687.1" /locus_tag="K5L50_RS10695" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="PqqD family protein" /protein_id="WP_005775830.1" /sec_met_domain="PqqD_RRE (E-value: 1.8e-10, bitscore: 35.1, seeds: 9, tool: rule-based-clusters)" /sec_met_domain="PF05402 (E-value: 2e-16, bitscore: 54.7, seeds: 461, tool: rule-based-clusters)" /transl_table=11 /translation="MADAKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR FLLPKGMSPDIHVRLEEHGTAVWELIDGKRTVRQIIEELAEHFDHEENYESCITAYITQ LQKDGFVKLAVTN" aSDomain complement(10019..10201) /aSDomain="PqqD_RRE" /aSTool="RREfinder" /database="RREFam.hmm" /description="RRE-containing protein in a pyrroloquinoline cluster" /detection="hmmscan" /domain_id="rrefinder_K5L50_RS10695_PqqD_RRE.1" /evalue="1.30E-11" /identifier="RREFam006.1" /label="K5L50_RS10695" /locus_tag="K5L50_RS10695" /protein_end="112" /protein_start="51" /score="35.1" /tool="antismash" /translation="MSPDIHVRLEEHGTAVWELIDGKRTVRQIIEELAEHFDHEENYES CITAYITQLQKDGFVK" gene complement(10361..11749) /locus_tag="K5L50_RS10700" CDS complement(10361..11749) /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1106: major facilitator transporter" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004301891.1" /locus_tag="K5L50_RS10700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="MFS transporter" /protein_id="WP_005775829.1" /transl_table=11 /translation="MTEQLRNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL PILNVWWFATVIMIILGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP LLIGWVLNTYCKGPVVDGAQTYDYTLPMSIFACFGVLALIVALMLKAEDKKKGYGLQEA NIKK" gene complement(11920..12300) /gene="secG" /locus_tag="K5L50_RS10705" CDS complement(11920..12300) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0015136 - sialic acid transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0015739 - sialic acid transport [Evidence IEA]" /codon_start=1 /gene="secG" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005775827.1" /locus_tag="K5L50_RS10705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="preprotein translocase subunit SecG" /protein_id="WP_005775827.1" /transl_table=11 /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA PKTDAAAPAEAPATETPATPAN" gene complement(12305..13069) /locus_tag="K5L50_RS10710" CDS complement(12305..13069) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005785470.1" /locus_tag="K5L50_RS10710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="WP_005809945.1" /transl_table=11 /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL YLLHDISFGAELRKAILYVADRRKLFYLIEGERYILKPRKKNMPSEAEVLEEEPGLDRT LSLIDAFLATVPEEVSGQTSLDYSTDYTTYLLQEDEEDSAPEQSEIPKLRGHELIDGFI ERSEGETSIRLQPAANNETLPVEEEGEAHHEEDEDDSCFTETLAKIYVKQHRYSKALEI IKKLSLKYPKKNAYFADQIRFLEKLIINAKSK" gene complement(13075..13596) /gene="lptE" /locus_tag="K5L50_RS10715" CDS complement(13075..13596) /GO_component="GO:0019867 - outer membrane [Evidence IEA]" /GO_process="GO:0043165 - Gram-negative-bacterium-type cell outer membrane assembly [Evidence IEA]" /codon_start=1 /gene="lptE" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008760046.1" /locus_tag="K5L50_RS10715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="LptE family protein" /protein_id="WP_005775825.1" /transl_table=11 /translation="MDWNKKIMRISLLVVTLVVGISCTVSYKFNGGNINYDKVKTISIA DFPIKSDYVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLQIDGEITGYNQYNQAVSAD GYSSETKLTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITD QIFNATVANW" gene complement(13583..14809) /locus_tag="K5L50_RS10720" CDS complement(13583..14809) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54 dependent trancsriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005785466.1" /locus_tag="K5L50_RS10720" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="sigma-54-dependent Fis family transcriptional regulator" /protein_id="WP_005775824.1" /transl_table=11 /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKQV LLSYSWPGNVRQLKNITEQISIIETNREINASILRTYLPAQNTQRLPALFGVKAGKSFE SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVASNVGTFYAPAPVVTPPPSVPALIH PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY RKIKEYGLE" gene complement(14834..15931) /gene="pdxA" /locus_tag="K5L50_RS10725" CDS complement(14834..15931) /EC_number="1.1.1.262" /GO_function="GO:0050570 - 4-hydroxythreonine-4-phosphate dehydrogenase activity [Evidence IEA]" /GO_process="GO:0008615 - pyridoxine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="pdxA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004289667.1" /locus_tag="K5L50_RS10725" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="4-hydroxythreonine-4-phosphate dehydrogenase PdxA" /protein_id="WP_005775823.1" /transl_table=11 /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEERLGDGSKSLMILMKEDFRV ALVTGHIPVREIASSITKELIQEKLVIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKAAHAN PLRKQYYEKRDDSDKLKLDTVDDDI" misc_feature 15890..15903 /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 18.59" /tool="antismash" gene complement(15936..16982) /locus_tag="K5L50_RS10730" CDS complement(15936..16982) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005785463.1" /locus_tag="K5L50_RS10730" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="DUF4837 family protein" /protein_id="WP_005775822.1" /transl_table=11 /translation="MKKYLFYLSMALVAVVLFSCKGGKKSVFTPTSSGRAYEILVVVDN PVWERPAGRALYNVLDTDVPGLPQSERSFRIMSTSANNFDAILKLVRNIIIVDIQDIYS QPKFKYAKDVYASPQMILTIQAPDEATFEKFVNENKQAIIDFFTRAEMNRQISLLEKNH NDFISKKVNSMFDSDIWLPAELGSSKTGEDFFWAGTNTASADQNFVIYSYPYTDKDTFT KEFFIHKRDSVMKANIPGAKEGMYMSTDSTTVEVRPIDIHGDYTMEARGLWRMKGDFMG GPFVSHTRLDKANHRIVTVEVFIYSPDKLKRNLMRMLEASLYTLQLPTEKKQEQIPMGI EQEEKTNK" misc_feature complement(16978..16991) /note="TFBS match to ANR, Anaerobic transcriptional regulator, confidence: medium, score: 20.8" /tool="antismash" gene complement(17058..18092) /gene="rlmN" /locus_tag="K5L50_RS10735" CDS complement(17058..18092) /EC_number="2.1.1.192" /GO_function="GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IEA]" /GO_function="GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IEA]" /GO_process="GO:0030488 - tRNA methylation [Evidence IEA]" /GO_process="GO:0070475 - rRNA base methylation [Evidence IEA]" /codon_start=1 /gene="rlmN" /gene_functions="biosynthetic-additional (rule-based-clusters) PF04055" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008768025.1" /locus_tag="K5L50_RS10735" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN" /protein_id="WP_022012997.1" /sec_met_domain="PF04055 (E-value: 3.5e-17, bitscore: 57.9, seeds: 518, tool: rule-based-clusters)" /transl_table=11 /translation="MPKYPLLGMTLTELQSVTKDLGMPAFAAKQIASWLYDKKVTSIDE MTNLSLKHRELLKGEYDLGVVAPVDAMRSVDGTVKYLYRVGENHFVEAVYIPDEDRATL CVSSQVGCKMNCKFCMTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNL DEVLKALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSE LMPAERAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELVKLLRGLDCRM NLIRFHAIPGVDLEGADMETMMAFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEE SDKN" misc_feature 18066..18083 /note="TFBS match to HipB, Bacterial antitoxin HipB, confidence: weak, score: 22.53" /tool="antismash" misc_feature complement(18242..18256) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: strong, score: 24.55" /tool="antismash" misc_feature 18549..18564 /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 17.55" /tool="antismash" misc_feature complement(19276..19289) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 19.79" /tool="antismash" ORIGIN 1 tttggtttcg caaacaaagt tacagattcc acataaacag gcaataccta aaagtaggga 61 atttattcga tagaagcaca gcatgaattt cgtttctatt tcataaatgt tacataaaca 121 ttacaacata actctttcat tatcaatatc tattaataat aaatattcat atattcagta 181 acaggtctgt aatacgaggg acctattttt gcgccagaaa acaacaagca gatgttatgg 241 acaatgtaca acaagtaaaa actaattcac aaaagaaact ttccgatttc cttttcattc 301 tttgggcagg tggtgctgca ttgctctcct actcactggt ttatgcacta agaaaacctt 361 atacggctgc cggattcgat ggacttgaga catttggaat ggattataaa gtagtggtca 421 ctatcgcaca gatattagga tacgtacttt ccaagttcat tgggatcaaa cttatttcag 481 agttgaaacg ggaaaaccgg atgaaattca tcctgatctc cattgtactg gcagaagctt 541 cgttgatact gttcggacta ctacctgcac cttataatat aggagctatg tttctgaacg 601 gtctttcatt gggatgtatg tggggaatca tttttagttt tatagaagga cgccgcatga 661 cggacatact cgccagcctg ttgggtgtca gtatggttat cagctcggga acagctaagt 721 ccgccggctt gtttgttatg gacactttaa acataagtga attctggatg ccggctctga 781 tcggaggtat tgctttacct atactcgccc tattgggtta ttctctgaac cggctcccac 841 aacccacggc cgaagatatc gccatgaaat cgaaacggga gacactgaac ggcaaacagc 901 gttgggatat cttcaagaat tttatgcctt ttctcaccct gctcttcatt gccaatgtag 961 tattgacaat cttaagggat atcaaagaag acttcctggt gaagattatc gatgtatccc 1021 aatactcttc gtggatgttt gctcaggtag acagcgtagt aactatcatt atccttgtca 1081 ttttcgggtt gatggttttt gtacgaagca acttgaaagc attatcgata ttactgggat 1141 tgatcatcat cagcatggta gtgatggtag tggtttcatt tggctacgaa caattgcaat 1201 taaacgctat tgtctggtta ttcattcaga gcctctgtct ttatctggct tttctcactt 1261 ttcagaccat tttcttcgac cgattcatcg catgctttaa aatccggggt aatgtaggtt 1321 tctttattgc catgaatgat tttctcggtt atacgggtac ggttatcgta ttggctgtca 1381 aagaattctt ttcacctgac attaactgga ctactttcta caacctgatg gccggctatg 1441 taggagtgat ttgttttgtc gctttcgtat gttcatttat ctatctgcat caacgttatc 1501 gtagagagaa ctacggaaaa acaggcgtat tcagaaaaaa agaagaagaa aaagaagttc 1561 ctgatttcgt atattaattg ctatctttgt gggtcaaaaa acttaaaata aaagttcacc 1621 atgaagattt ttccaagtag cagcatcaaa aaactggatg cttacaccat agaacatgaa 1681 ccgattgcat cgattgacct gatggaacgg gcagcgcagg cactgacaaa agccatcact 1741 gaacgttggg acatcacaac tcctgtcacg gtatttgcgg gaccgggtaa taacggcgga 1801 gatgcccttg ccgtggcccg catgctggcg gaaaaggaat ataaggttga agcctatctg 1861 tttaacccga aaggagaact gtcagccgac tgtcagacca acaaagagtt ggtggaaatg 1921 atggataatg tgaagttcag tgaagtaagc acacaatttg tacctcctac cctgacaatg 1981 gatcatttgg tagtggacgg actttttggt tcgggactca ataaaccgtt aagcggcggt 2041 ttcgcggctg tagtgaaata tatcaatgca tcgcctgcta cagtggttgc tatcgacatc 2101 ccttcgggat tgatgggaga agaaaacaca tttaacgtaa aagccaatat catccgtgcc 2161 catctgacac tgagcctgca attgcccaaa ctggcttttc tcttcgcaga gaatgccgaa 2221 ttcgttggtg aatggaaatt gctggatatc aacctcagcc atgaagccat cgaagaaaca 2281 gaaagcaatt atgccttatt ggaagcagaa gagatacatg ctttgatcaa accccgcagc 2341 cccttttcac acaaaggaaa tttcggacac gccttgctga ttgccggatc gtatggtatg 2401 gcaggggctt cagtgctggc ggcccgtgcc tgtatgcgtt cgggggtagg attgctgact 2461 gtacacgcac ccatgcgtaa caatgacatc ctacagattt ccgtcccgga agcaattgtc 2521 gaactcgatg ccagtgattc ctgctttgct tttcccacag atacagatga ctatcaggcg 2581 gtaggtatcg gtccgggaat cggacgctca gaagaaacag aagccgcatt gctcgagcaa 2641 ctcagtggat gccagactcc tttggtgctg gatgccgatg cactgaatat attagccaac 2701 caccgacatg cactgaccac gctccccaaa ggctccatcc tgacccctca ccccaaggag 2761 ctggaacgta tggtgggcaa atgccagaat tcgtacgagc gactgatgaa agcttgtgaa 2821 ctggctcgta ccgctaaagt acatattata ttaaaaggag cttattcagc aattatcacc 2881 ccttcgggca aatgttattt caactccaca ggtaatccgg gcatggcgac agccggaagt 2941 ggagatgtgt tgacgggtgt cgtactggct ttactgacac agggataccc ggctgaagaa 3001 gcagctaaaa taggtactta cgtacacggt ctggccggcg atttcgcacg caaaaagcag 3061 ggcgttatcg gtatgacagc cggagatatt gtcaattatt tgccaatggc ctggcgtctg 3121 gtaagcgaat aaaggttaac aacttatgat tttccaaata acttcattaa ctttgttttt 3181 taaaccagtt aaaataaacc ggaaaatgaa aaagctaatt atactgacag gactgttact 3241 ttctgcctcg gcatatgccc agacagaagt tacagcggga gttacccggg gaaaagatta 3301 cggggtgacc tatgcacttc ctaaaacagc aatcgacatt gaagtcaaag ccaataaagt 3361 gacatacact ccgggagaat tcagcaaata tgccgaccgt tatctgcggc tgaccgatgt 3421 gtcgggagag cctcaggaat attgggaact ggtcagcgtc aaagccaaat ctgtcggtat 3481 ccccgatagt gaccatacct atttcgtcaa actgaaggac aaaacagtgg ctccgttgat 3541 agagttgacc gaagacggta ttgttaaatc gatcaatgta ccgttaagtc cgaagaagtc 3601 tgcacctata caaccagcca ctacgctgag aaaaaaagta aatccacgcg attttctgac 3661 agaagagatt ctgatggcgg gttctacagc taaaatggct gaattggtcg ccaaagaaat 3721 ctacaacatc cgcgaaagca aaaacgcctt agtacgcggc caggcagaca acatgcctaa 3781 agacggagaa caactgaaga taatgcttgc caacctggaa gaacaggaag ctgccatgac 3841 cgaaatgttc tcaggtacac tgaataaaga cgagcggata tttactatcc gcctgaatcc 3901 ggaaaaagag atggataacg aagtggcctt ccgcttttcc aggaaactgg gtatagttgc 3961 caataatgat ctggcaggag aaccggttta cattactctg aaaaatctga aaacagtcaa 4021 tgtaccggaa gacgatggca aaaagaaagt agacggcata gcttataacg tacccggtaa 4081 ggcgcaagtg acgctcatag aaggaaaaaa agaatggttt aacggtgaac ttcccgttac 4141 acagttcgga acaattgaat atctggctcc ggctcttttc aataaaaaat cgaccgtaca 4201 agttactttc aatccggcta caggaggatt gattaaagta gatagggaag aaggagaata 4261 aagcataaaa ctgacacaac ctcatcagtt ccagtttttt catatgcttt tccatttcaa 4321 actacaatta tgcgtcagat ggccggtgaa tacgtccact gcattataaa gggctaaagg 4381 atgaaaaatg ttcaccctgc accggaaaaa tcttcggtat caaaacaggt attccaaccg 4441 ttgatattaa aagctataaa aataaaatgg aacaaatatg gaggatatga agaagttttt 4501 accggaagcg gatctctcaa aactaaggac tatacttgat ataaagaatt cttataactg 4561 cgggacgctc tctcttgaag atgcccgtaa acttcttaag gagaaagtgg tagtcttgaa 4621 actatatgaa ataacgtttg ctgaacagga actgaaggga ggggaggaga atgagtgccg 4681 caaggaggat attcagcgca tgctggaact ttttaacggc ataatggaca cttcacgccc 4741 cgatttaccc ccggagtatt ctgtcatgta ttattatcgt ggaaacgacg agttacgtaa 4801 aatcctgccc tcaattgagg ggctggtccc ccctccttac ccgacaaatc cggaacagaa 4861 ccagtacccc gtctaccttg ttgaaggact tattggcggc atatcctctt ttgaaagaca 4921 ggatggagga gatcagcccc aagttcaaac tgctcaggtc ccctttggcg cgggttatac 4981 tacccagagc caccatcagc acgataaccg ataaactagt atcccggcgg acacactagt 5041 tgaatccctg aggtccagga tcgagaaact tccactattg cagacatttt tttcacagag 5101 ctatatggta cgattccccg taaccctttc tccgaaccag gattacgggg attgttatcc 5161 ttatacgggg cacttatcgt ctggggactt tcatctcgtc cccccagtgc gcctttgcct 5221 cccgttcctc acgctcacgt atttcctttg ccttgcgcgc atatacgatg atacgcagtg 5281 actggtcata ggtgaaatag ttccacatcc agttcaacag cacgttgacc ttgttcctca 5341 ctcccaagat ggagcgcaag tgaacaacca gccataacac ccatgccatc aatccttgtg 5401 tcctcaccct attgaattcc gctaccgcac ggtttcttcc tacagtggcc atggagccca 5461 gatccctgta tccgaacggt ctcatcggct ttttccttgc cattcttttt aggttggcgg 5521 ccagtaaccg cccctgttgt atggctactt gggccagctg cggatgccct tccggatact 5581 tcctgtcagc agtcattatg cactggtctc cgattgcaaa aacattctcg accccctcta 5641 ctcggttgaa tgcgtccact tttatgcgtc cgccacgtcc tatgcattct gccggcatgt 5701 tgcccaccgg gactgccttt acaccgctta cccagatgaa agagcgtgtg ggtatggcca 5761 ttccgtcctc cagtatcact ttgtggtccc tatagtcaac tacacgcttg tgcaagcata 5821 tgttaacccc catattgcgg agaaactgct cggcccttgc ggaggattcc gcggacatgc 5881 ccgaaagtag cctacccgca gcctctatca aaaatatatt gattctgctg ctgtccatat 5941 ccggatagtc agccggaatt acatatttcc tcatctccga gagtgcccct gcaatttcaa 6001 ctccggttgc tcccccaccc acaatgacta tgttctgcaa ctcctgtttc tcctgttcgg 6061 tggagcatgt gatacttctt tccagattgg acagcaacgc attcctgagt cccatcgctt 6121 cggaaaccgt cttcatgggc atggcctctt cctcgatccg gctgttcccg aaaaaattgc 6181 tggttgtgcc taaggccagt accaggtagt catagtcgat ttttccgata gatgtctgaa 6241 ttattttctt ttcgggataa atcccccgca attcggccat tctgaaataa aagttcttcc 6301 ttttcctgaa tatcctcctg aaagggaatg atatcgaact cggctccaat ccggaggatg 6361 cgatctggta aatcagcgga gggaactggt ggtaattgtt cctgtcaagt agaatgacct 6421 ggtaatcaga cttccggagt tctccagcta gtttcaaacc tccgaatcct ccacctgcga 6481 taataattct tttctggtta tgatttcttg caatattaaa actcatttat ctatatatgt 6541 taatgtttaa aagattcatt aatctgtgtt ctgcatgaag tatatagact tggactttca 6601 gttgcctatc atcaggataa cggcactttt tcaaaaaaga gcggaacata tggatatgat 6661 ccgtgacaat atatcttcgt cattatacca tcctagttac aaaaaagaag ctgcaatgag 6721 ataaactgcc gccgccaata atccgcttac cggaatggtc agcacccagg cagtcatcag 6781 atttttggta actccccagc gaaccgctga cagccgctta gtggccccta ccccgatgat 6841 agctcccgta atagtatgtg tcgtactcac tgggatcttc agatattccg ttagatacag 6901 cgtaaaggca ccggctgtct ctgctatgac tccctccaaa ggggttacct tggtaatttt 6961 ggttcccatc gtctttacaa ttttccatcc accggacatc gtacccagtg agatggccgt 7021 aaaacaagag aatgccaccc agtccggcaa atcatcaata ctgtttatcc ccattcccaa 7081 actttcagaa tgtcccgcta tcatggcagc ggcaataata cccatcactt tctgggaatc 7141 gttcaatccg tgtccgatac tgaacatagc tgaagaaaca agctgcagtt tcttgaacca 7201 gacctcggca gtatggggat gcgcccgttt acagatataa aacaccagca aagtaacccc 7261 gaatgcaatg accatgccta tcagaggagc caaaaagatg aaaaccgcaa tcttcagtat 7321 gatattcaac tgaatggctt caaaaccgtg agccataatg gctgctcctg caaaaccgcc 7381 tataagggta tgcgatgatg acgaaggaat acctttccac caggtaaaca ggctccaaac 7441 aatggcagct atcacccctg ccaggataac gggcaatgtg atgtatggct ctactaccgt 7501 tttcgatacg gtattggcta taccaaagcc cccaatgacg tatttggcta taaagaaagc 7561 taaaaagtta aagaatgcag cccatatcac ggcctgaaaa ggagtcagca ctttagtaga 7621 tacaatagtg gctattgaat tcgctgcatc gtgaaaaccg ttgatgtaat caaatatcag 7681 agccaatacg atgataatca ctaatagttc catgtgttat gcctgtttat gcgtatttca 7741 caatcaaact tcttaatatc ttgcccacat gctccgcagc atcggtggtc ttttccaatt 7801 cgtacacaat ctccttaatc ttgatgagtt cgatacagtc cttctcctcc tcaaaaagtt 7861 tggtgataaa taattcgtac acatcatccg catggttttc aatatcatgc attttcgaac 7921 aatatccacg caaagtattt ggattctgac ggaaagtctc gagctcgtcc attgccttga 7981 caatgtattc cgcctcctgc tgaatcatac ggctcagttc cttcccgctt tcggagatag 8041 gatgcggatt atagatggca atacgttttg cgcaactgtt tataccgtca atcacatcat 8101 caatacctga agccagatca tggatgtcct cacggtcaaa tggcgtaata aaagtggttc 8161 ctagttcgtc cagaatccga tgggtaagct tatccccctc acgttccata tccttgatcc 8221 gcttatagaa aatggccctt ttttctggtg aatcatgctt catcccttcc actaaaagtt 8281 ccgatgaagc agtcagtatt tcagacaact gtttcagcaa aggaaaaaac ttgggttctt 8341 tgggtgtaaa tctgctaaaa aaagaatttt tcataaatgt gtgtatttaa aattatttcg 8401 tttgtttacg agttttcaga cgggcacgta taacctcgat cacagcaggt aatactgata 8461 ctactatgat agcgacaatc agcagtttaa ggtttttctg tacgaaagga aggtctccaa 8521 aaaaatatcc cgcgtagcag aaaatggcaa cccacaacac tccgcccgtc agattgtaca 8581 gcatgaaata gtaatagtgc attttaccca ttcccgccac aaatggggca aatgtacgga 8641 caatgggcac aaagcgtgca aggataatag tcttaccgcc atacttttta taaaactcat 8701 gtgttttctc aagatggctc tgcttgaata tcctggaatc gggattacgg aacagcttcc 8761 gcccaaagaa ataccctatc atataattgc aagaatcccc caaaacagca gcagcaaata 8821 aaattaagac cagcacattc acctcgacaa gcatatcggg tagtgcagca atggcacccg 8881 ccacgaacag cagggagtca cccggcaaga acggtgtaac caccagaccg gtttcgcaga 8941 aaataattaa gaataagatg acatacgccc aggtatggta ttcttgtacg atgtcaatca 9001 tatattgatc gacatgaaga atgaaatcca ataaaaaatc cattttgtat catttatcag 9061 tgcttaaata agaagaaaga tacaaagaga taaagatccc tttgaaaaga gaaaaaaagc 9121 actaaataag aatgcgcctc agtgtataga cataatatct ataagagaag ttgaaaggcc 9181 ttatactgaa tgaaaaggag atcgtttttt cttcaggaag taaaaccttc agagatttca 9241 ccattctggc aatgatcaag gctgtattgt ccctcaatat cttggaaggg gagatacaac 9301 ggaacgaaaa gttatttcct atacagactc tgtccgtcct gtcattgtag gatccacacc 9361 atattcctgt ttcatggcga tccagatcta actcaaacaa accgtgctgg tttccggaaa 9421 catgccggat atctatggta tgcgacacct tgtattcctt tatatcatcg gaggctgaca 9481 ccacctttaa tatgaggaac aatcctaata acatatagaa gatatacttc gccatagcga 9541 ctgcaaagat agaaagtatt tttaagtgtg ggaaccttgc cggattttta ttttcatctt 9601 tccggattga atttccgggc ggcttctgtt atttgtcacg ttttatggat tgggcgaaac 9661 atttcggata ttatagagac ttttcaaaag gcatgatacc gatatcagac gacgagacat 9721 cttctacatg acaaggatag tctgcgttaa aagttatgaa gtgtctgttt aaacatcatc 9781 atctgtccgt tcgcaatcac taacgtaaga ttatgctccg gcaagtttta cgaggatgtc 9841 cttctgatat cctcataccg ctcggaacaa tatctcggta tccataccga caaccttctt 9901 cggaaatatt ggcggctatt gttatggaaa tggggcatgt gcacttcatt tttggcacac 9961 cccctttttt attttcttaa attgtgcttt tcaaacaccg tcagttcgta actgctaatt 10021 tcacaaatcc gtccttctgc aactgggtga tataagcagt aatacacgat tcgtaatttt 10081 cttcgtgatc aaaatgctct gcaagttctt caataatctg gcgtacagtc cgcttcccgt 10141 caattaactc ccatacggca gtaccatgtt cttccagccg gacatgaata tccggagaca 10201 ttcctttggg caataaaaaa cgccgcatcc attcatattt aaaccggggg aaagcaatgg 10261 taacggtacc atcgcttccc ttttcggctg taatattctc actacggaaa ggaattacat 10321 ccaaaagatt tattttctct ttcgcgtctg ccatattctg ttatttctta atattcgctt 10381 cctgcaatcc gtatcccttc ttcttatctt cagctttcag catcaaagcc acaatcagtg 10441 ccaaaacacc aaaacaagca aagatagaca taggcaaagt ataatcatag gtctgtgcac 10501 catctacaac gggacctttg caataagtat tcagtaccca tccgatcaac aaaggaacac 10561 ccatcaatcc ccagttctgt acccagaaaa tcagggcata ggctgtaccc agttgtttct 10621 ccggaataat tttcggaaca gaaggccaca tggcagaagg caccagtgag aaggcaatac 10681 ccagaattat cataattaca gtggcaaacc accatacatt aaggatagga agcgcaaaca 10741 aagtatgtac gccaatcaac ataacggcac cgataatcat taatgtagct cccttaccga 10801 tacggtcata aagagtacca aacaacggag tcaggaagat ggtccctatc ggtagtaatc 10861 ctgggatatt tccggccaat ttaggatcta cgttatactt ctgcaccatc aaatcagttg 10921 catatttaat aaaggggaag acagcggaat agaacaatac acacaataaa gcaatcaacc 10981 agaatccctt attagtaaca ataagcataa catccttcat acggaacggt tcctccggtt 11041 cttctccctg agcatctaaa gaagcatcaa gtttcttatc ataaaaggta tagataaaga 11101 aggcgatagt accgatgcac agcataatca gacacaacaa aataggcatc ggaatattgg 11161 tatggaaact gccactttca tccgtatagc caaaataatc ggcaatagga acagtaagta 11221 ccattgccaa agtagtaccg atacgtgcgg ttgccatctc aagtcccatg gctaaagcca 11281 tctctttgcc cttaaaccat tttacaataa tcttggaaac cgtgatacct gcaatctcta 11341 cacctacacc aaagatagca tatcctaaag cagccagaaa gacctgagtt ttgaagccca 11401 taatcaaagc accttcgggg aaagttgtag aaatagcata atatttcagt ccacaaccca 11461 gcaccatcag tatacaggct cccattccgg tgaaacgaac tcccatctta tcgagaatga 11521 taccaccaaa aatcaacatc agcaggaata cattaaacca cccgtaagcg ctggtaaaga 11581 atccataatc caaactatcc caaaggagct ctttttcgag catgggtttc aaaggagaca 11641 ttacgtcggt aaggaaatag ccgcaaagca tagtaaaagc gaccagagcg agcacactcc 11701 aacgaagtgt tttggagtca ctcagtttgt ttctcaattg ttctgtcatt gtaatattta 11761 aactcagaag ttagtaaaag tgttatagcg aacaaaggta actaaatccg ccttgtatgc 11821 ctaacaaaaa gatacatttt acggctaaaa acaagtgaag ctgcaagttt cggtttgaaa 11881 ttgcagcttc acttatcgtt tcttaaaaag aatctgttgt tagtttgccg gggttgccgg 11941 agtttctgtt gcaggtgctt cagccggagc agcagcatcc gtcttcggtg cagtagtacc 12001 tacaggcagg ttatacgggt tggtctgttc ttcctgctga gcctgttcca tgatgacatc 12061 ttgcgtttta gaagaagaag tcggaacaac ataagcagta gcaatgctca tcacaaccat 12121 aaatgcagct aagccccaag ttgccttttc cagaaagtct gtagttttgc gtacacccat 12181 aatctggtta gatgacgaga acccagaagc aagaccaccg ccttttgagt tctgaatcaa 12241 cacaatgaag cacatcagta tggctgcaat aaccattaag ataactaata ataagtacat 12301 tttgttattt tgatttagcg ttaataatca atttctctaa aaatctgatt tggtctgcaa 12361 agtaagcatt tttttttgga tatttcaaac ttaatttttt aataatttca agtgccttgg 12421 aatatcggtg ctgtttgaca tatattttgg ctaatgtttc ggtaaaacag ctatcatctt 12481 catcttcttc atgatgcgcc tccccctctt cttccacggg aagcgtttca ttgttagctg 12541 cgggctgcag acgaatggat gtttctccct cacttctctc gataaagcca tcgatcaatt 12601 catgcccacg aagtttcgga atctccgact gttccggagc ggaatcttct tcatcttcct 12661 gtaacagata agtagtataa tccgttgaat agtccagact tgtctgcccg gaaacctctt 12721 caggcacagt ggccaaaaaa gcatcgatca gggagagtgt acgatccaga ccgggctctt 12781 cctccaacac ttctgcttcg gaaggcatat tctttttacg gggcttcaaa atatacctct 12841 caccttcaat cagataaaac agcttccggc gatctgccac atataatata gctttacgaa 12901 gctccgcacc gaaagagata tcgtgtaaca gataaagatt tttaagatag agtaaacgca 12961 gcgactggaa ataaggatag cgtgtgacaa gtgtccgcaa ctcgtacaaa gtatctttat 13021 tcagcgtttc aggatgctga atccattgtt gtaaattagc agaaatcatc ccaattacca 13081 atttgctacc gttgcattaa atatttgatc tgtaatctct ttggtcatct ccgcaatcag 13141 tccgtcctga acagctgtca gtaactctct tgagtcgtag acacggaaag ccgagaattg 13201 ctgttcgaag tcctgctcat ggttcgtatt attcacaaaa cgaacattta ccgtaatcgt 13261 cagcttcgtt tcagaagagt atccatcggc cgaaacagct tggttatact ggttgtatcc 13321 ggtgatttct ccatcaatct gaaggtcggc attattattc accagcttca ggcgagtctg 13381 gcgaaggaag atatctttca gatcttcatt gaatttagta cctaacggtg cataaacata 13441 gtccgacttt ataggaaagt cggctataga aatagtcttt accttatcgt aattgatatt 13501 accaccatta aatttataag aaacagtaca cgagatgccc actaccagcg tgacaaccag 13561 tagtgagatt cgcattatct ttttattcca atccatattc ttttattttt cggtaaaggg 13621 tacgctcaga gatattgagg tcctttgccg cactttttcg tttgccatga tgtttctcaa 13681 gggctttacg tatcatttct ttctctacct cgtccagcga aagagactct tcaacatact 13741 cttcggtatc ctgtatgtca tcgtcatcgg gacaattagg cttgaccgga tggatcaggg 13801 caggtacaga aggcggaggc gtcacaacag gagccggggc ataaaacgta ccaacattgg 13861 aagctacagc tccgcgttcg gacatgattt cgtgcacaag ctttttcagt tcggtcacat 13921 cctgccgcat atcaaagaga acctgatata aaatttcacg ttcactttca aaactcttcc 13981 cggcctttac accgaacaaa gccggcagtc gttgtgtatt ctgggcaggc agataggtcc 14041 gcaaaataga agcattgatt tcacgatttg tctcaatgat ggagatctgt tccgtgatat 14101 tcttcaattg gcgcacatta cccggccatg aatatgacaa caaaacctgt ttggcatctt 14161 cggtcagttg tatcgcaggc atacgatatt tctccgcaaa atcacttgca aacttgcgga 14221 acagcaacag cacgtcttct ccacgttccc gcaaaggagg aatctggatg ggtaccgtat 14281 tgagacggta atacaaatcc tcacgaaaac gcccttcagc aatggcttgt gtcagattga 14341 cattagtagc agccacaata cggacatctg ttttctgcac tttggaagaa cctactttta 14401 taaactctcc actttcaagc acacgaagca aacgcgcctg agtaggcaaa ggcaactccc 14461 cgacttcatc cagaaagata gtccctccgt cggcctcgcc aaaatatcct ttccgctcac 14521 caatagcacc tgtaaaagcc cctttttcat gcccaaatag ttccgaatca atggtcccct 14581 caggaatagc accacagttc acggcaatat actggccatg tttacgacgg ctatactgat 14641 gaataatctg aggaaagctt tccttgccga caccactctc tccggttatt agcacggaca 14701 aatcggtagg cgctacctgt atggcaacat ctatcgcacg cgtcaaggct tcagtgttac 14761 caataatacc gaaccttagt tttacttgtt gtatttccgc ttttgtcata ttcgcactaa 14821 actcccttcc tgattaaata tcgtcatcta ctgtatcgag cttcagttta tcactgtcgt 14881 ctcttttttc gtaatattgt ttacgcaacg gattggcatg tgctgccttt tcacgctggc 14941 ggttacggaa tacatcaatc gctacataaa tggcttgccg gaatgaatct tcacaagcaa 15001 ccccttttcc tgcaatatca taggctgtac cgtgcgctgg agaagtgcgt atcacaggca 15061 gacctgccgt ataattcaca ccttcatcca tggccaatgc cttgaaaggt gccagtccct 15121 gatcatgata catagcgagc actccgtcaa aatgggtaaa attacccgat cccataaagc 15181 cgtcagccgg ataaggacca taacataaga ttcctttagc ggccatctcc tggatagccg 15241 gagaaatgat ctcctgttct tccgtaccga gtaacccgtc atctccggca tgtggattca 15301 gtgccaacac tgcaatgcga ggtgcgccga ttccaaaatc ctgtttcaac gaacggttga 15361 aaatgacaag tttctcctga atcagctctt tggttatcga agaagctatc tcccgaaccg 15421 gaatatgacc ggtcaccaaa gccacacgga aatcctcctt catcaggatc atcagagatt 15481 tcgaaccgtc tcccaaacgc tcttcaatat attcagtatg tccggggaaa gcgaatcctt 15541 cggactgaat tgtatgctta ttaataggag ctgtcacaat gacatcaatc aacccttccc 15601 tgaactcctc tatcgctttt tcaagtgccc ctaaagctgc tttaccggcc tccggatcgg 15661 gttttgaaaa ttcgactttc acttcgtcat ccgtacaatt gactacactc aaccgattgt 15721 gtgcagcttc tgcagcagta ttgacaatac tgaagttagt aggcagatcg agtgatttac 15781 ggtgatatgc agccaccttc ggcgaaccgt aaatgaccgg tgtacaaagt tccaacatga 15841 cggggtcggc aaaagtcttc aagattactt cgtatcctac cccgtttatg tctccctgag 15901 tgataccaat ttttattttg ttatcttcca ttttgttatt tgttagtttt ctcctcctgc 15961 tctatgccca tcggaatctg ctcctgcttc ttctcggtag gaagttgcaa agtatacaga 16021 gatgcttcca acatgcgcat caggttacgt ttcaatttat ctggtgagta aataaatacc 16081 tctacagtga caatacgatg gttagccttg tccagacgag tgtgcgaaac aaacggacca 16141 cccatgaagt cacccttcat acgccaaagc ccacgtgctt ccattgtata gtcgccatga 16201 atatcgattg gacgaacctc gactgtagta gagtctgtcg acatatacat accttcttta 16261 gctcccggaa tattagcttt catcacagaa tcgcgtttat ggatgaaaaa ctctttcgta 16321 aacgtatcct tatcggtata cggataagag tagatcacaa aattctgatc agcggaagct 16381 gtattcgtac ctgcccagaa gaaatcctct ccagtctttg aactgcccaa ctcagccgga 16441 agccagatgt cgctatcgaa catactgtta accttcttcg aaatgaaatc attgtggttt 16501 ttctctaaca gggaaatctg gcgattcatc tcggcacggg taaagaagtc gataattgct 16561 tgcttgtttt cattcacaaa cttttcaaat gtggcttcgt ccggagcctg aatagtcaga 16621 atcatctggg gagatgcata tacatccttg gcatacttaa atttaggctg actatagatg 16681 tcctgtatat ctacgataat aatattacgt accagcttca ggatagcatc gaaattgttc 16741 gcagaagtag acatgattct gaacgaacgt tccgattgcg gaagtccggg tacatctgta 16801 tcaagcacat tgtacaaagc tctaccggca ggacgctccc acacaggatt atcaacgacc 16861 accaggattt cgtaagcacg tccgctggaa gttggagtaa acacactttt cttgccgcct 16921 ttacaagaaa acaatactac tgctacaaga gccatactga ggtaaaacag gtactttttc 16981 atatgcatca attttaatgt tttcacaaaa ctacgaaatc accgtataca tatagtctac 17041 gaagctgata atttatatta attcttgtca ctctcttcct gcttggcagt cgataacata 17101 ccacaggcag caaaaatatc ttctcccctt gaagcgcgaa tcgtagtaaa caatccgtgc 17161 gacgtcagat aatcacgaaa tgccatcata gtctccatat cggcaccttc aagatccact 17221 ccgggaatgg catgaaagcg aatcagattc atccggcaat caagcccacg aagtaacttt 17281 accagctctt tggcataaat caacgaatca ttgacacctt taaaaacaat gtattcaaac 17341 gaaagtctgc gttgtttact aaaatcatag ttttttaaca gatcgaccat ctcttttatc 17401 gagaaggctc tttcggcagg catcaactct gaacgctgtg aaggaaaggg agaatgcagg 17461 ctgatggcca gatggcactc gctttcttca ataaaacgct gtagtccctt ccgtaacccc 17521 accgacgaca aagttatacg ttttggactc caaccgtatc catacgaagc tgtcaggata 17581 tgcaatgctt ttaaaacttc atccaagttg tcaagcggtt cacccatccc catcataacg 17641 acattggtca acttgtcccg ctccggcaat gccgcgatct gatttaaaat ctgattggca 17701 gtcagacttg ctgtaaatcc ttgcttgccc gtcatgcaaa atttgcagtt cattttacac 17761 cccacttggg aagacacaca cagtgtcgcc cggtcttcat caggaatata taccgcttca 17821 acaaaatggt tctctcccac gcgataaaga tacttcaccg taccatctac ggaacgcata 17881 gcatccacgg gtgcgactac tcccaaatcg tactcgcctt tcagcaattc tctatgcttc 17941 aacgacaaat tagtcatttc gtcaatagaa gtcacttttt tatcgtacaa ccaggaagct 18001 atctgtttgg ccgcaaaagc cggcatcccc aagtctttgg taacagattg caattcggta 18061 agagtcattc ctaaaagcgg atatttgggc atatttacta caaatattta tttattcatg 18121 caaatgtaag gaataaaagt tgatttttga aaagagaaag gacaaaagtt aataagaaga 18181 aggaaagaga gaacaaaaag aaaaggccat tccacaagga atgacctttt atctataaaa 18241 ctattttctg aaaaaaacga gtcttgtttt tagaagaaca ggtaacgctt gtcttttaca 18301 tcacctttca gataaagatc gttcatgaaa cgggcagcca gacgggcatg catattttcc 18361 agagtaacct cctctgcctt ggcatcgaat gtttcattca acttatcttt ggcatatacc 18421 tgcaatacaa atacaccgcc attacctttg ataggagcgc tcagtttatt aatatcggct 18481 accgatgcat aagcacctac cagcggttcg ctactacgca aagcagctac ataggcagga 18541 gccgcaaatg ttacgtgttt cacagaatcg ctcactgcat tggccattga tttatactga 18601 tcgaaagaag ttgcattgac agccttcatg tcagccataa ttttttcagc cttcttatca 18661 cgaataattt ctgctcttaa ctgatcctga acctgagcca aaggacgata accttcttcg 18721 atcacgttaa ccaggccgac aaccaacata cgatcgctct caccacattc atacaaaccg 18781 gaaacttcac cgggttttgc agcaaatgtc catttcagag cttctttggt tcctctgata 18841 ccaccgattc cgtgttccga gctatacaaa tcatttcttt caagcaattt ataacctgct 18901 tcttcagcat tagccgccat cttttctacc gtcggattgg ctgcgataaa ctgactgaag 18961 tcattatatg ccttattata agtttctttg ctgaagtcaa ctgcgcgttt gattacggca 19021 actttatatt tatctttcac agctttcttg tcagtaacct gcaaaatgat gttaccctgt 19081 cccaatgcta cattagagag ttcgttcact cccaggttgt tgatcgtggt gataaacttc 19141 aggttgtcac catcaatctg tgcattttcg tagttagcag aagaaatcca gttggattca 19201 cctgtctgtc catacttttt agccaaagcg gtgaagtcgg ccccaccttt aattgctgta 19261 taaatactat cagccaaaac ttttgtttta gcagcatctt cagcataaac ctgaatctga 19321 cggaactgta cagaatcggc agcagccact ttagacaaaa ccttgaaaga gttaatggta 19381 ttatcaccgg cattataata aggaccatat atctgtccca ttgaagctga atccatccgt 19441 gcaactacat ctgacggaaa agctctttta gtataataca aatcaacgta aggatattca 19501 gatcctgtcg aacggatgaa agtagtataa tcaccattag cagtagccaa ctgatttgta 19561 taatcagtca cttcctgctg aatagcggct ttatcttccg cactggcagt cacctgtacg 19621 tcgatatatt tgatattgcg tgtttcaaca tattgtttga actgttcttt cttcttatta 19681 tagagatctt tcagctctga ctctttcact gtaatggtag aatcaacaat tgaagaataa 19741 ggcacagcag ccaacagtac atccgattgg ttcactcttg catcgaaagc atcttgtgct 19801 tcaaccgggt tagagaaaag agcctttgtc accaatgcct gatatttttc agccagacgg 19861 ctctgaatca gagttttttc aacgaatgac caaagtttgt gcatgccttc atagtattct 19921 acatattgag acggcatctt agttttgtcc attttagaat agtcagacaa aaatttcttc 19981 aacatatctt tatcgaaagc acccgtttgc ggattgcgga acggagtctg ttgcagcaac 20041 ggattcacac cttcgttgat gatagactga atttcagcct ttgaaactgt aatccccagc 20101 ttcttcgctt ctttttcaat cagtttattg ttcacgtagc tacgccatac ttcgtctttc 20161 acctgattgg tttgttcatc gttcaatgaa ctcattccgc tggagaactt gatgacttca 20221 gtatattctt ctaccatatt ctggtagtcc tgagcagaaa gagtttctcc gttgacttcg 20281 cctacatcat gcgactggtg tggctggaga actttccagg catcgcccgc aatgaaagca 20341 aacaaagcca aacc //