LOCUS       NZ_JAFKPO010000003     20492 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Bacteroides fragilis strain FSHXHZ1E1 Scaffold3, whole genome
            shotgun sequence.
ACCESSION   NZ_JAFKPO010000003
VERSION     NZ_JAFKPO010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacteroides fragilis
  ORGANISM  Bacteroides fragilis
            Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
            Bacteroidaceae; Bacteroides.
REFERENCE   1  (bases 1 to 709958)
  AUTHORS   Wang,C., Li,S., Hong,K., Yu,L., Tian,F., Zhao,J., Zhang,H., Chen,W.
            and Zhai,Q.
  TITLE     The roles of different Bacteroides fragilis strains in protecting
            against DSS-induced ulcerative colitis and related functional genes
  JOURNAL   Food Funct (2021) In press
   PUBMED   34308455
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 709958)
  AUTHORS   Wang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAR-2021) School of Food Science and Technology,
            Jiangnan University, 1800th Lihu Avenue, Wuxi, Jiangsu 214122, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 2.3 OR MAY-2011
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 12x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019633825.1-RS_2024_12_15
            Annotation Date                   :: 12/15/2024 11:10:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,946
            CDSs (total)                      :: 3,876
            Genes (coding)                    :: 3,807
            CDSs (with protein)               :: 3,807
            Genes (RNA)                       :: 70
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 26 of 69
            Pseudo Genes (incomplete)         :: 50 of 69
            Pseudo Genes (internal stop)      :: 15 of 69
            Pseudo Genes (multiple problems)  :: 19 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 187154
            Orig. end                         :: 207646
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAFKPO010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20492
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20492
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20492
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10492](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10492
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    103..116
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     gene            682..1155
                     /locus_tag="K5L50_RS08560"
     CDS             682..1155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014299122.1"
                     /locus_tag="K5L50_RS08560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_220654025.1"
                     /transl_table=11
                     /translation="MNILILSNADSCRSRIAQALLSSLGKGMKIYSAGTAPAAEVHPLV
                     LKLIKETGIEPDTRPPHSIYEYTNKSWDTIIVLSETTDEIRNHFSKEVKHWYYLPFDEL
                     FPTIPADGTDLWEGLLCLKEEIGKKIYELYRDELKEQLLPRCTCGANDFCRCE"
     gene            complement(1162..4827)
                     /locus_tag="K5L50_RS08565"
     CDS             complement(1162..4827)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011203140.1"
                     /locus_tag="K5L50_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_220654026.1"
                     /transl_table=11
                     /translation="MRYLNKIVFINSARIQYAEIQIDGNVHFIGTQGVGKSTALRALLF
                     FYNADKTKLGISKEKKSFDEYYFPYLNSYIIYEVTVDDASYCVLAFRSQGRVCFRFLGT
                     GYKKEYFISPEGKAYEEWDQIRDALGSFVYKSRRVETYEEYRDIIFGNNRGLPPELRKF
                     AITESRQYQNIPRTIQNVFLNSKLDAEFIKQTIIMSLNEEDVRIDLGQYAHHLRRFDEE
                     VTDISKWFRKNKNGEVTVRRQADRVIELYREMHYLEQQARTLAGELNYTFRMAQELLPS
                     LQQKKEELLKELAKEKHQLEELSGKFQSERDRLLGLVRVQNENLKTARERKERYESQDI
                     YNVCDRVNAEPEAILHKQMLEEQLTMLTARFDDINSQYKLLKEQASSAFERFRNGKNAE
                     LNTLHLRAIERKEAVRKEYDKILKEVREQEVGKLTLLREQTEKKKEGIYQLKMEREKCL
                     HRTFHEEELQACRTERVALEKENHECRLKLKEAEQQMGLVRRQWELDQTACEQQSGVRQ
                     KEIEQQIAVGREKVAEIDRLLDNCQGSLYEWLSRNCPGWENTIGKVVDEKLVLFSKELN
                     PQSVPDTGQDSFYGIKLDLSAIRKEVKSVQEYASEQEAIRKEIHEWQQNLEKSIEEKEK
                     ELAAIRKKHQTVLNTYKEEMAQSAYCMEQNDKRIQVLKADEIILEQKAGEEKRILLEQL
                     EKQLAEATHSLQESAAELEQFNHLLETRIRQKEKERNQRMQEEDTLIRNKQEEIHQSIA
                     SEKKKTDELLGTMDKDLLHELSGKGVDTERITALRNEVVRTEQELAFIEQHRRLVYDYE
                     KDKREFFDRMDEFRNGKQLAEKELDGEKEKFRLKEEELNQKVTGLNKQLAETNTRLKHL
                     EEDIRETENFKTLNICPPVLQTGVEAESVKRCKKVIEELTQNHYRQIEQEKDFREAVGR
                     FTGNFSEQNTFNFRTRLTKRDEFMTFAADLKEFIDNDKIIDFERRSNEAYTDLIHRIGK
                     ETADMLSKEGLIRKTINDINSDFVERNFAGVIKSIALQIVPSGNRIMQHFVTIKEFCDR
                     NQPGALGMFSLFGQEELVEQNRQAVSLLQSLVKELALNKEKELTLSDTFELQFRIVEND
                     NDSGWVEKLANVGSDGTDILVKAMINIMLLNVFKEKASHQFNDFKLHCMMDEIGKLHPN
                     NIKGILDFANNRNIILVNSSPTSYRASDYKYTYILNKDKRNITSVTRLIKQEVRE"
     gene            complement(4811..5371)
                     /locus_tag="K5L50_RS08570"
     CDS             complement(4811..5371)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005788879.1"
                     /locus_tag="K5L50_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensin complex protein MksE"
                     /protein_id="WP_032530369.1"
                     /transl_table=11
                     /translation="MIKQTAEIFEILSKGGFISSDSTNPNIRQLYTVIEDNQSELYDFF
                     AAINFILESGNEYYYFSRRENKVDLERKLEIAARWIDVLDFIKTYDAAFSSGFRFQPAD
                     MVVKVGTDLELKEKLAGLKKLVGREKHEEMIDKIVNDLKRDGFIELENEITSTYKVVAA
                     FGYLEELVACINISEEIQNEIPE"
     gene            complement(5510..6724)
                     /locus_tag="K5L50_RS08575"
     CDS             complement(5510..6724)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005780125.1"
                     /locus_tag="K5L50_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_005780125.1"
                     /transl_table=11
                     /translation="MTTFHSIDELLKMMSREQLLLKQMFSKRKQQSFRREYALELTEYK
                     LQRIQSLIDHGVLRENGSFLEMEDIYLHFFEQVLEVNEEINTSFVNEHISYLKDTISYY
                     QQENHEKRKTTYLRTIKRILRNIALTTLRNVIDLKRNIDSTFKNEPNYQIKKKKLVRLD
                     EKRRDIEALIKVSEELLANEEDRFFRRIPDEELGLVVANVRIQLNECFHNLIEIQKQII
                     SYLNKIEYQNKIRVKIRQLKYLKDQFELEERTNICEVLMQKDSVWFEPAPAYPLRLSVE
                     YLRNDDEVLESIRKVITMIGKRAILTRNVAGSIAEDSLETHISEEAYINLEEVKKRFMQ
                     AEEDLFSFVAAYPFAQEVSFDERITFYCQIVSQFYEELRITGDYGRMGGVEYALIYSER
                     TGEIV"
     gene            complement(6755..7687)
                     /locus_tag="K5L50_RS08580"
     CDS             complement(6755..7687)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008769713.1"
                     /locus_tag="K5L50_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_005807317.1"
                     /transl_table=11
                     /translation="MNINSKAKGFVCGAVAAATYGMNPLFTLPLYKEGMSVDSVLFYRY
                     GFAVLILGILMKVQGQSFALKRNEILPLVAGGLLFSASSLLLFLSYKHMDAGIASTILF
                     VYPVMVALIMFLFFHEKVSLLTVFCILLALSGIGLLYKGEGGETLSLVGMLLVILSSLS
                     YAVYIVGVNHSTLKLMSTAKLTFYALLFGLSIYIVRLNFCADLQAVPSFPAWGNILAMA
                     FLPTVISLVCTAVSIHSIGSTPTAILGALEPVTALFFGVMIFGERLTPRLMLGILMILV
                     AVMFIVVGKPLMTFIKEELARGMKKKLIR"
     gene            7772..8068
                     /locus_tag="K5L50_RS08585"
     CDS             7772..8068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008769712.1"
                     /locus_tag="K5L50_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrous oxide-stimulated promoter family protein"
                     /protein_id="WP_005780129.1"
                     /transl_table=11
                     /translation="MSKNRIDQEKRVVELMIRLYCRKKEKNVTLCPQCEELLRYAHARL
                     DRCPFGEKKKACKQCSVHCYKPAMRERMKQVMRFSGPRMLIYAPWEAIRHLFG"
     misc_feature    8086..8099
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.68"
                     /tool="antismash"
     misc_feature    complement(8113..8126)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 26.16"
                     /tool="antismash"
     misc_feature    complement(8114..8129)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            8150..9280
                     /locus_tag="K5L50_RS08590"
     CDS             8150..9280
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005780131.1"
                     /locus_tag="K5L50_RS08590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_220654027.1"
                     /transl_table=11
                     /translation="MTIIRNPFITSGYVSSDYFCDREKESETLIREVSNGNNLALISTR
                     RMGKTGLIQHCFRERKIRKDYYTFFIDIYATKSLRDFVFALSKEILEELKPSGKKALQL
                     FWKSVKSLHTSVSFDINGTPSLSLGLGDIQAPATTLDEIFHYLNHADKPCLVAIDEFQQ
                     IAGYAEDNVEATLRTYVQHCSNAHFIFAGSQRHIMGNMFLTPSRPFYQSVSMMHLESIP
                     LAKYTAFAQLHFAQARKSITDETVETIYRRFDGITWYMQKVLHTLYDMTPAQGTCEVKM
                     VEEAIRQIIDSFKFTYSEILFRIPEKQKELLIAITKEGKAKAITSAAFIKKYKLSSSSS
                     VQSALKGLLEKDFITQELGIYQIYDQFLGIWLKENY"
     gene            10001..10492
                     /locus_tag="K5L50_RS08595"
     CDS             10001..10492
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005820917.1"
                     /locus_tag="K5L50_RS08595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_220654028.1"
                     /sec_met_domain="AgrB (E-value: 5.5e-07, bitscore: 24.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIYTASSAADQTACWITGIVIAALIFLFVKFAAKGSKPLEKIMLA
                     SGCVIVLLTTLIVKVPAPDSFNPETGFSEKERRKDRRILIRIFSAIGLTALWFIPIRNT
                     EWFEALIEKHIWVTPAMLAVFLLAGWILTGQLTRWYAKERRTDKHTGRKKRSSQRNRTP
                     "
     gene            10507..11247
                     /locus_tag="K5L50_RS08600"
     CDS             10507..11247
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005820920.1"
                     /locus_tag="K5L50_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_220654029.1"
                     /transl_table=11
                     /translation="MKRAVIIGATSGIGREVAKQLLLQGWHLGIAGRRLPSLEALQSSA
                     PDRVEVAALDVTQPDAAPKLSNLIRRVGGMDLFLLSSGIGYQNIGLNPDIELETTRTNV
                     EGFTRMVDTAFNYFREHGGGQLAVISSVAGTKGLGVAPAYSATKRFQNTYIDALEQLAC
                     MQKLNICFTDIRSGFVSTDLLNDGKRYPLLMQPEKVARQIVRALHHRKRVAVIDWRYAV
                     IVFFWRMIPRWIWKRLPIRTGKTM"
     gene            11295..11564
                     /locus_tag="K5L50_RS08605"
     CDS             11295..11564
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005780137.1"
                     /locus_tag="K5L50_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_220654030.1"
                     /transl_table=11
                     /translation="MEQKFCQSCGMPLSPEVLGTEKDGSKNEEYCTYCYADGHFTVDCT
                     MDEMINHCAQFVDEFNKDSEMKMTKEEAIANMKQFFPMLKRWKQ"
     gene            complement(11757..12020)
                     /locus_tag="K5L50_RS08610"
     CDS             complement(11757..12020)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005788897.1"
                     /locus_tag="K5L50_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_005780139.1"
                     /transl_table=11
                     /translation="MEEYEVTHRPERNRFELEKNGMTAFVEYEVEDGTLDIMHTIVPPP
                     LEGKGIAAALVEATYKYAAGQGLKPKATCSYAVAWLKRHPVE"
     gene            complement(12055..13380)
                     /locus_tag="K5L50_RS08615"
     CDS             complement(12055..13380)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005820922.1"
                     /locus_tag="K5L50_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR01777 family oxidoreductase"
                     /protein_id="WP_220654031.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.4e-06, bitscore:
                     21.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIAISGASGFIGKHLTEYLTERGHRIVPLGRPMFREGTSGHLIQ
                     ALSHCDVVINLAGAPISKRWTPEYKKELYDSRIKVTHRIIRAMDAVKTKPRLMISASAV
                     GYYPEDGTFDEYTNTRGSGFLAELCYAWEKEARRCPSQTRLTITRFGIVLSPDGGAMEQ
                     MLRPLRITRVAGVIAPGTQPFPWIGIQDLCRAMEFIINHEVLSGVFNLVVPQQVSQYAF
                     TRAMAARYHAWMKVVIPRWFFRMQYGEAASFLTSGQNVRPTRLLEAGFRFDKPTIEAFF
                     EGTDHSTVDELDLQRYMGTWYEIARFDHRFERGLSEVTATYILLPDGTVRVENRGCKHK
                     KPYDVCKTAEGRAKVPDSSQPGKLKVSFFLSFYSDYYVLELDQEEYNYVLIGSSSDKYL
                     WILSRTPILPEEIKKKLLDAAIRRGYDVDKLIWVEQREKNLK"
     gene            complement(13429..14286)
                     /locus_tag="K5L50_RS08620"
     CDS             complement(13429..14286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005798668.1"
                     /locus_tag="K5L50_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="WP_193683729.1"
                     /transl_table=11
                     /translation="MKSSRTTSVSNKPAPRRHTSVRKRKAKKKASRTMPVWLRNTLALV
                     VVGLFSVAFYYFVIRPYSYRWKECYGRKEYGVCIPCGYEVHGIDISHYQGNIDWEELKQ
                     NKETDFPLHFIFMKATEGGDHGDDTFKQNFEQARQHGFIRGAYHFFTPRTDALKQADFF
                     IRTVKLDSGDLPPVLDVELSGKKPKKELQQSIKKWLDRVEAHYGVKPILYTSYKFKTHY
                     LDDSLFNAYPYWIAHYYVDSVKYQGKWHFWQHTDIGSVPGIHHDVDLNVFNGSLEELRK
                     MTMR"
     gene            complement(14320..16023)
                     /locus_tag="K5L50_RS08625"
     CDS             complement(14320..16023)
                     /EC_number="3.2.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014299132.1"
                     /locus_tag="K5L50_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sialidase family protein"
                     /protein_id="WP_220654155.1"
                     /transl_table=11
                     /translation="MKRLSTLCLLAAGFFLSGQAQQARPLVLDSVCAPLKVATPPSDAY
                     IGLSLLDNGEVRHYNYGEQAVAGAVYLSSADHGLTWKRVNRAKEMPFADRQSPVSKEYI
                     RLVDMGAMGVYCIRTSGGLAGGRTLTKVADRSSIMIKPPVFIRNGKRIVVAAHGGVTPK
                     GCYTYVSDDDGLTWKCSNTVTSPDHRGGGFHKGIRWNHGAVEPTVVELKDGTLWMLMRT
                     SQDRHYQAFSQDGGLTWSESEPSPFYGTITMPTLGRLADGRLLLFWCNTTPLPEKEGTN
                     GVWDDVFTNRDVTHVAVSDDDGKTWTGFRELYMDPMRNDSDYAVNGGGIDRGVHQAQFV
                     EVAPGKVLASIGQHPLHRAMMMFDVNWLYEKSRFNNFSDSLSQWSTFNYIDGIKGHCAY
                     NRIQGCRLESHPEKEGCQVLHLSYQLDASLVADTRGAVWNFPAMKKGTFTASLRIPEGS
                     HSVSLLLNDRWMNPSDTVARYESMYELPLTRKQLGVKDDRWHEVSLEWDLSQKRPQARV
                     RVDGRLRSLRLPLRNKSQNGISYVHFIAPPAEANPGIYLEWVRAEADGTI"
     gene            complement(16122..17765)
                     /locus_tag="K5L50_RS08630"
     CDS             complement(16122..17765)
                     /EC_number="2.7.1.90"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0047334 - diphosphate-fructose-6-phosphate
                     1-phosphotransferase activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007570582.1"
                     /locus_tag="K5L50_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diphosphate--fructose-6-phosphate
                     1-phosphotransferase"
                     /protein_id="WP_005780146.1"
                     /transl_table=11
                     /translation="MTKSALQIARAAYQPKLPKALKGSVKAVEGAATQSVADQEAIQKL
                     FPNTYGMPLIKFEEGEAIQLPAMNVGVILSGGQAPGGHNVISGLFDGIKTLNKDNKLYG
                     FILGPGGLVDHNYMELTADIIDEYRNTGGFDIIGSGRTKLETPEQFEKGLEIINKLGIK
                     ALVIIGGDDSNTNACVLAEYYAAKNAGVQVIGCPKTIDGDLKNDMIETSFGFDTACKVY
                     SEVIGNIQRDCNSARKYWHFIKLMGRSASHIALECALQVQPNVCIISEEVEAKDMSLDD
                     VVTYIAKIVADRAAQGNNFGTVLIPEGLVEFIPAMKRLIAELNDFLAANAVEFANIKRS
                     RQREYIISKLSKENADIYASLPEGVARQLSLDRDPHGNVQVSLIETEKLLSEMVGTKLA
                     QWKEEGKYVGKFAAQHHFFGYEGRCAAPSNYDADYCYSLGYTASMLIANGKTGYMSSVR
                     NTTAPAAEWIAGGVPITMMMNMERRHGEMKPVIQKALVKLDGKPFLTFAAKRDQWALTT
                     DYVYPGPIQYFGPTEVCDQPTKTLQLEQAK"
     misc_feature    17738..17750
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.78"
                     /tool="antismash"
     misc_feature    18139..18154
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.39"
                     /tool="antismash"
     misc_feature    18665..18679
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.48"
                     /tool="antismash"
     misc_feature    complement(18975..18988)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.35"
                     /tool="antismash"
     misc_feature    19025..19039
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(19690..19703)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.96"
                     /tool="antismash"
ORIGIN
        1 gacagccgaa agatatttga agggatcatt gctccggatg aatacttcga tgtaaccatc
       61 tgtaatcctc ctttccacag ttccagagaa gaagctgaag acgggacgct gcgtaaactc
      121 agtagcctaa aggggagaaa aataaccaaa gcccggctca acttcggagg caatgccaac
      181 gaactctggt gcgaaggtgg agaacttcgc tttctgctga ccatgatcga agagagccgg
      241 aactaccgaa agaattgcgg atggttcacc agcctggtat cgaaagaaaa gaacctgggt
      301 aaactgaccg ccaaactcaa atcagtcggt atatctgaac ataggattat cgagatgcat
      361 caaggtacta aaaccagccg gattttggca tggagattct gagaaagata tagttactaa
      421 attagcaagt atctactcaa atctttcaag gaggcggcct taataaaaga tcatccgcaa
      481 tgcagagata tcattgaggt caaacagttt atcaccccaa acaaaccaat tccggaaaac
      541 gtgttttaac actgtattaa aacttgtttt ctacaaacaa aagacttgtc ctttaactgt
      601 gcaaaagaag tcctttgttt gcaaacaatc agaatcattc attccgagtt aacactgtta
      661 ataggaaaac tatacattat tatgaacata ttaatcctca gcaatgctga cagttgccgc
      721 agccggatcg cacaggctct tctttcctcg cttggaaaag gtatgaaaat atattctgca
      781 ggaacagcac ccgcagcaga ggttcatccg cttgtcctga aattaataaa agagacaggt
      841 atcgaacctg acacacgacc tccccattcc atctacgaat ataccaacaa aagctgggat
      901 actatcatcg tcctttccga gacaaccgat gaaatccgta accacttctc caaagaggta
      961 aaacactggt attatcttcc tttcgatgaa ctgttcccta ccataccggc agacggaacg
     1021 gacctatggg aaggcttgct ctgcctgaaa gaagagatcg gcaagaaaat atacgaactg
     1081 tatcgtgacg aactgaagga gcagttgctc ccgcgatgta cttgcggagc caacgacttt
     1141 tgcagatgtg agtgagggaa attactccct cacctcttgc tttatcagcc gtgtcacgct
     1201 tgtaatattt cgcttgtctt tattcaggat ataagtatat ttgtaatcgc ttgcccggta
     1261 agaagtaggc gaactattca ccaggataat attccggtta ttggcaaagt ccaaaatacc
     1321 tttaatatta ttgggatgca gttttccgat ctcatccatc atgcagtgca gcttgaagtc
     1381 gttgaactga tgcgatgcct tttccttgaa cacattcagc aacatgatgt taatcatggc
     1441 cttcaccaga atatccgttc catcggaacc tacatttgcc agtttctcca cccatccgct
     1501 gtcattatcg ttctccacaa tgcgaaactg aagttcgaaa gtatcagaaa gcgtcagttc
     1561 cttttccttg ttcagtgcca gttctttcac cagcgactgc aataaactta ccgcctgccg
     1621 attctgttcc acaagctcct cctgaccgaa caggctaaac atgcccagag cacccggttg
     1681 attccggtcg caaaactctt tgatggtaac aaaatgttgc atgatacgat tgccactggg
     1741 cacaatctgt aaagcaatgc ttttgatgac cccggcgaaa ttgcgttcca caaagtcgct
     1801 gttgatgtcg ttgatagttt tgcgaatcaa cccttctttt gaaagcatat ccgccgtctc
     1861 tttcccgatc cggtgaatca agtcggtata tgcttcattc gaacgacgtt caaagtcaat
     1921 gatcttatca ttatcaatga actctttgag atcggcagca aaggtcataa actcgtcgcg
     1981 ctttgtaaga cgtgtacgga agttgaacgt attctgttcg gagaagttac ccgtaaagcg
     2041 gccgaccgct tcccggaagt ccttttcttg ttcaatctgc cgataatgat tctgtgtcag
     2101 ctcctctatc actttcttgc agcgcttcac actctctgct tccactcccg tttgcagtac
     2161 aggcggacaa atattgagtg ttttgaagtt ctcagtctcc cggatatcct cttctaaatg
     2221 cttcaggcgg gtatttgtct cagccagttg cttgttcagt cccgttactt tctgattcag
     2281 ttcttcttcc ttcaagcgga acttctcttt ctcaccgtcc agttctttct cggccaactg
     2341 ctttccattt ctgaattcgt ccatacggtc gaagaactcc cgcttatcct tttcgtaatc
     2401 gtaaaccaga cggcggtgct gctcgataaa cgccaactcc tgttccgtgc ggaccacttc
     2461 attacgcagg gcagtgatac gttccgtatc cacccctttt ccggaaagtt catgcaacag
     2521 gtccttatcc attgtcccca gcagttcatc ggttttcttc ttttcagaag caatggactg
     2581 atgaatctcc tcctgcttgt tacggatcag agtgtcttct tcctgcattc tctggttacg
     2641 ttccttctct ttctggcgga ttcgggtttc aagtaagtga ttgaactgtt ccagttccgc
     2701 cgctgactcc tgcaaactgt gtgtagcctc agccaactgt ttttccaact gttccagcaa
     2761 tatacgtttc tcttcgcctg ccttctgctc cagtatgatt tcatctgctt tcagaacctg
     2821 aatacgctta tcattctgtt ccatacagta agcggactga gccatctctt ccttataagt
     2881 attaaggaca gtctggtgtt tcttccggat ggcagccagc tctttctctt tttcctctat
     2941 cgacttctca agattctgct gccattcatg tatctcctta cggattgctt cctgctctga
     3001 ggcatactcc tgcacacttt tcacttcttt ccggatagcc gaaagatcga gtttgatgcc
     3061 atagaaagag tcttgtccgg tatccggaac agattgggga ttgagttcct tactgaataa
     3121 aacaagtttt tcgtctacca ccttaccaat ggtattctcc catcccggac aatttcggct
     3181 caaccattca taaagtgatc cctgacagtt atcaagtaac cggtctatct ccgccacttt
     3241 ttctctacca accgcaatct gctgctctat ttccttctga cggacgcccg actgttgctc
     3301 acaggcagtc tgatccagtt cccattgccg acgtaccagc cccatttgtt gttctgcctc
     3361 tttcagcttc aaccggcatt cgtgattctc cttttccaat gcaacgcgtt ccgtccggca
     3421 ggcctgtaac tcttcttcat ggaaagtccg gtgcaggcac ttctcccgtt ccatcttcaa
     3481 ctgatagatg ccctcttttt tcttttctgt ctgttctcgc aggagggtca acttccctac
     3541 ttcctgctca cgcacctctt tcaatatttt atcgtactcc tttcgcacag cctccttacg
     3601 ttcgatagca cgtaaatgga gcgtattcag ctcagcattt ttaccgttac ggaaacgttc
     3661 aaaggcactg gaagcctgtt ccttcagtag cttatactgg ctgttgatgt cgtcaaagcg
     3721 ggcagtcaac atggtcaact gctcctccaa catctgtttg tggagtatgg cttcgggctc
     3781 cgcattcacc cggtcgcaca cattataaat atcctgcgac tcataccgtt cctttcgttc
     3841 acgcgcagtt ttcaagttct cgttctgtac cctgacaagt cccagcaaac ggtcgcgctc
     3901 actctggaat ttcccggaaa gttcctcaag ctggtgtttc tcttttgcca actctttcaa
     3961 cagttcctct ttcttctgtt gcagtgaagg gagcagttcc tgtgccatcc ggaaagtata
     4021 attcagttcc ccggccagcg tacgcgcctg ttgctccaga taatgcattt ccctataaag
     4081 ttcaattacc cggtcagcct gccggcgaac agtaacctcg ccgttcttgt tcttcctgaa
     4141 ccacttgctg atatcagtca cctcttcatc gaaccgtcgc agatgatggg catattgccc
     4201 cagatcgata cgcacatctt cttcgttcag tgacatgatg atggtttgct tgatgaactc
     4261 agcatcgagc tttgaattca ggaaaacatt ctgaatggta cgcggtatat tctggtactg
     4321 acggctctcg gtaatggcaa acttccgtaa ctccggagga agcccccggt tgttgccgaa
     4381 aatgatgtca cgatactcct catacgtctc tacgcgacgg ctcttataga caaagctgcc
     4441 aagggcatcg cgtatctgat cccactcttc gtaagccttt ccttcgggag aaataaaata
     4501 ttcttttttg taacccgttc ccagaaaacg gaaacaaact ctcccctggg agcgaaaagc
     4561 caacacacaa tacgatgcat cgtctacggt cacttcataa ataatatatg aattgaggta
     4621 cggaaagtaa tattcgtcaa agctcttttt ctcttttgat atgcccaact tcgtcttgtc
     4681 ggcattgtaa aagaaaagca gcgcacgtaa cgccgtactc ttccccaccc cctgtgtacc
     4741 gataaagtgg acattgccgt ctatctgtat ttcggcatat tgtatacgag cactattgat
     4801 gaaaacaatt ttattcaggt atctcattct gtatttcttc tgatatgtta atacaagcga
     4861 ccaactcttc cagatagccg aaagccgcta ctactttata ggtggaagtg atctcgttct
     4921 ccagttcaat gaagccgtca cgtttcaggt cattcactat tttatcgatc atctcttcgt
     4981 gcttctcccg tccgacaagt ttcttcaatc cggcgagttt ctctttcagt tccaggtcgg
     5041 tacccacttt tacgaccata tcggccggct ggaaacggaa tccggatgaa aaagccgcat
     5101 cgtaggtttt aatgaaatcg agcacatcaa tccagcgggc ggcaatctct aacttacgct
     5161 ccagatcgac tttattttcc cgacgggaga aataataata ttcattcccg ctctcaagga
     5221 taaagttgat ggcggcaaag aaatcgtaca actccgactg attatcttcg atcaccgtat
     5281 agagttggcg gatattggga ttggtactgt cggaagagat gaatcctcct ttactcagta
     5341 tttcaaatat ttcagcagtt tgtttaatca ttactataat ggttatggat tcgggttcac
     5401 caccgaggac acagagggca cagagtttta atcttttgtt tatcaggatg tttaagagaa
     5461 agacattctc tgtgtcctct gtgtcctcgg tggtgaatcg tattcgtttc taaactatct
     5521 cgcctgtcct ttccgaataa atcagtgcat attccacccc acccattctg ccataatcac
     5581 cggtgatacg gagttcttcg taaaactggg atacaatctg gcagtagaac gttatccgct
     5641 catcaaaaga aacctcttgt gcgaaaggat aggcagccac aaacgaaaac aaatcttctt
     5701 cagcctgcat aaaccgcttc ttcacttcct ccagattgat ataagcctct tccgatatat
     5761 gggtctcaag agagtcttcg gcaatgctgc cggccacatt ccgggtcagg atggcacgct
     5821 tgccgatcat ggttatcact ttacggatgc tctccaacac ttcatcatca ttacgaagat
     5881 attctacgga gagacgtaac ggataagccg gtgcaggttc gaaccagaca ctgtctttct
     5941 gcatcaacac ctcgcagata ttggttcgtt cctccagttc gaactgatct ttcaggtatt
     6001 tcagctgccg gatcttaacc cggatcttgt tctgatactc tattttgttc agatagctga
     6061 taatctgctt ttgtatctcg atcaagttgt ggaaacattc attgagctgt atccgtacgt
     6121 ttgccaccac aagccccagt tcctcgtccg gtatccgccg gaagaagcgg tcttcttcat
     6181 tggcaagaag ctcctcgctc acttttatca atgcctcgat atcccgccgt ttctcgtcca
     6241 ggcgaaccag ttttttcttc ttgatctgat agttcggctc attcttgaaa gtgctgtcga
     6301 tgttacgctt caggtcgatc acattgcgca aggtggtcag ggcgatatta cgtaatatcc
     6361 gcttgatggt acgcagatag gtagttttcc gtttttcgtg gttttcttgc tgataataag
     6421 agatagtatc tttgagataa ctgatatgct cgttaacaaa cgaagtgttg atctcttcat
     6481 tcacttcgag tacctgctcg aagaaatgca gataaatatc ctccatctca agaaacgaac
     6541 cattctcacg aagcactccg tgatcgatca ggctctgtat acgttgtagt ttatattctg
     6601 tcagttccag tgcatattcc cgccggaagg attgctgttt ccgcttgctg aacatctgtt
     6661 tcagcaggag ttgttctcgg ctcatcatct tcagcaactc gtcgatagag tgaaatgtag
     6721 tcatgtataa cggctataag cttttcagga ttccttatct tatcagtttt ttcttcattc
     6781 cccgggctaa ctcttccttg ataaaagtca tcaatggctt acccactaca ataaacatga
     6841 ccgctaccag aatcatcaga atgccaagca ttaatctggg agtcagccgt tcgccaaaaa
     6901 tcatcacccc gaagaaaagt gccgtcaccg gctccaatgc tcccagaatg gcagtaggcg
     6961 tagagccgat gctatgaatg gaaacagccg tacataccaa tgatatgacg gtaggcaaga
     7021 aagccatggc aagaatattg ccccaggcag gaaacgaagg aacagcctga agatccgcgc
     7081 agaaattcag gcggactata taaatggaaa gaccgaacaa cagcgcgtaa aaagtcagct
     7141 tggccgtaga catcaacttc agcgtggaat ggttgacacc gactatatag acagcataag
     7201 acagtgagga aaggataacg agcaacatac cgaccagact cagcgtttcg cctccctccc
     7261 ctttgtacag cagtccgatg ccggaaaggg cgagcagaat gcaaaagacg gtcagcaacg
     7321 acactttttc gtggaaaaac aggaacatga taagcgccac catcaccgga tagacaaata
     7381 agatggtgga agcaatgcct gcatccatgt gcttatagct cagaaacaac agcagtgaag
     7441 aggcagaaaa aagcagtccg cctgcaacca gaggcaatat ctcgttcctt ttcagagcaa
     7501 acgactgtcc ctgcactttc atcagaatcc ccaaaataag tacggcaaac ccgtaacgat
     7561 agaacaatac agagtccacc gacatccctt ctttatagag cggcagtgta aacaacggat
     7621 tcatgccgta agtagcagca gccacagctc cgcaaacaaa tcctttagcc ttactattaa
     7681 tattcattat tatattcaat tttcggggtg caaagataca gttttttgga gatgttggtt
     7741 acttttgcgt caattctaac agagattaaa attgagcaaa aaccgtattg atcaggaaaa
     7801 gagagtggta gagctgatga tccgtcttta ctgccgtaaa aaagaaaaga atgtcacgct
     7861 ttgcccccaa tgcgaagagt tgcttcgcta tgcgcatgcc cggctggacc gctgcccttt
     7921 tggggagaaa aagaaagcat gcaagcaatg cagcgtacac tgctacaaac ctgccatgcg
     7981 ggaacggatg aaacaagtaa tgcgtttctc cggtccccga atgctgattt atgcaccttg
     8041 ggaagcaatc aggcatctgt ttggataagc aggcacagag aagaatatta ttattataat
     8101 tgcattatta ctttataata attatctttg cttattaaag taacgaacca tgactatcat
     8161 cagaaacccc tttataacca gtggatatgt atcttccgat tatttctgcg accgggagaa
     8221 agagagcgaa accctgatcc gggaagtaag caacggaaac aatctcgccc tgatctctac
     8281 ccggagaatg gggaaaaccg gattgattca gcattgcttc cgcgaaagga aaatccggaa
     8341 ggactactat acctttttta tagatatata tgccaccaaa tcacttcgtg actttgtatt
     8401 cgcactgagc aaagagattc tggaagaatt aaaaccttcc ggcaagaaag ctttgcaact
     8461 cttctggaaa agcgtcaaat cattgcatac aagcgtatct ttcgacatca acggcactcc
     8521 ttcactgagt ctgggactgg gagacataca agctccggca acaacgctgg acgaaatttt
     8581 ccattacctg aaccatgccg acaagccctg cctggtagcc atcgacgagt ttcagcagat
     8641 agccggatat gcggaggata atgtagaagc aaccttgcgc acctatgtcc agcattgcag
     8701 caatgcccat tttatctttg ccggaagcca gcgccacatc atgggaaata tgttcctcac
     8761 cccttcgcgc ccattctatc agagtgtttc catgatgcat cttgaaagta ttcctttggc
     8821 aaaatacact gctttcgcgc aactgcactt cgcccaagca agaaaaagca tcaccgatga
     8881 aacggttgaa accatctacc gacgatttga cggcatcacc tggtacatgc agaaagtgct
     8941 ccacacactt tacgacatga ctcccgcaca gggaacctgt gaagtgaaga tggtggagga
     9001 ggccatccgc caaatcatcg actcgttcaa attcacctat tctgaaatac tgttccgcat
     9061 accggaaaaa cagaaagagt tactaatcgc catcacaaaa gagggaaaag cgaaggctat
     9121 tacttcggca gcttttatca agaagtacaa gctatcctct tccagctccg tacaatcggc
     9181 tctgaaaggt ctgctcgaaa aagatttcat cactcaggag ttgggaatat accagatata
     9241 cgatcaattt ttaggtatct ggctaaaaga gaactattaa gtccttcaaa agccaaacac
     9301 tccaagaaag aatttccaat agatttcttt caaaaagata gtaaaacccc ttatctgccg
     9361 acagcctcca tttacaaaaa gagacaaata gagagatgga gcgacagata atgaaaaaac
     9421 atgcaaggac aagtctttat tctctcataa aaatgcaata aaaagcagat atatgcagtc
     9481 ccccactcta tcagagcctt tgttgacagc aaagaaaggg tgcgttggtc ctaaacgaac
     9541 ggtgcattgg cttcaaagag acggtgcgtt cctctacgag caacgccgca cgggtaaaaa
     9601 agaagagtaa gatgggctgt ttacgaacta tcagagccac cgtaccgcac gaatcaaatc
     9661 tactaaaaga aagtaatcac acacaaaaaa gatcatttac taagatcata aaaacatata
     9721 tcacacaatt ttccaacaat atcccaaatt ctccatcata ttgctttacc ttaatcctcc
     9781 tacaagcgtt ttttcagtcg ccacatcctc cggcatgaaa ccaaggctgc ctgagagtga
     9841 tagaatatac aaaatgacat tttatcgccg ctacaatttc ccctccttta ttctgccaac
     9901 cttataaaaa cagcatttta aaacggaagg tcgcatttta gaaagattta attatctttg
     9961 ttgctgcaaa cccagttata tttcaccttt tcgtaaggaa atgatataca cagcatcctc
    10021 cgccgccgac caaaccgcct gctggattac aggcattgtt atcgctgccc tgatctttct
    10081 ttttgtgaag ttcgcggcaa aaggcagcaa accattggag aagataatgc tggcatcggg
    10141 ctgcgtaatc gtactgctga ctacactcat cgtcaaggtg ccggcacccg acagcttcaa
    10201 cccggaaacc ggattttcgg agaaagaaag aagaaaagac aggcggatac tcatacgaat
    10261 attctcggcc atcgggctga cagccctgtg gttcataccg atacggaaca ctgaatggtt
    10321 cgaagccctg attgaaaaac atatctgggt gactcccgca atgctggcag tgttcctact
    10381 cgcaggatgg atccttaccg gacaactgac ccgatggtac gcaaaagagc gccggacgga
    10441 taaacacacc ggacggaaaa aacgttcttc tcaaagaaac agaacaccat aaaagtaaat
    10501 tcaaatatga aacgagccgt tatcatagga gctacttcag gcattggacg tgaagtagcc
    10561 aaacaacttc tcctacaggg ctggcacctc ggtattgcag ggcgccggct tccgtcactc
    10621 gaagctttgc agagcagcgc accggaccgc gtagaagtcg ccgcactgga cgtcacccaa
    10681 ccggatgcag cccccaaatt gagtaacctg atcaggcgag tcggaggtat ggatctgttt
    10741 ctgctgagct ccggcatcgg ttatcagaac atagggctga atccggacat cgaactggaa
    10801 accacccgta ccaatgtgga agggttcacc cgtatggtgg acactgcttt caattacttc
    10861 cgtgagcacg gcggcggaca actggctgtg atcagttccg ttgcggggac aaagggattg
    10921 ggagtggcac ctgcctactc tgccacaaag cgttttcaga acacctatat cgacgcactg
    10981 gaacagttgg catgcatgca aaaactgaac atctgtttta cggacatccg ctcgggcttt
    11041 gtgtctaccg acctgctgaa cgacggaaaa cgttatccgc tattgatgca accggaaaag
    11101 gtagcccggc agattgtacg ggcattgcac caccggaaac gagtggcagt gatcgactgg
    11161 cgctatgctg tcattgtctt tttctggcgg atgattccgc gctggatatg gaaacggctg
    11221 ccgatacgga caggaaagac tatgtgacaa gaatatatat ccctattgaa taattcatta
    11281 aaaacaaaga aagaatggaa cagaaatttt gccagagctg cggtatgccg cttagcccgg
    11341 aagtattggg aacagaaaaa gatggcagca agaacgaaga atactgcacc tattgttatg
    11401 ccgacggaca tttcaccgtg gattgcacga tggacgaaat gatcaaccat tgcgcacagt
    11461 tcgttgacga atttaacaag gattcggaaa tgaaaatgac gaaggaagag gccattgcga
    11521 acatgaagca attcttcccg atgctgaaga gatggaaaca gtgaaacgta actcaaacag
    11581 acatctgtga cgcataaaca aaggagagtg tgtcgaaact caccacagag ggcacagagt
    11641 aacacagagt gaattttaag tcatcgatga ttaacattct aatctgtgac aatctgtgta
    11701 atcccctggt gaaaaggctt ttgacacatc tcctgctgta tcggaagagg taccgtttat
    11761 tccaccggat gccgcttcag ccaggctacg gcatacgaac atgtcgcttt cggcttcaga
    11821 ccttgtccgg cagcatattt gtaggttgct tctaccagag ctgccgcaat cccctttcct
    11881 tccagagggg gaggaacgat ggtatgcata atgtccagcg ttccatcttc cacttcatac
    11941 tccacaaaag cagtcattcc attcttttcc agttcaaaac gattccgctc cgggcggtga
    12001 gttacttcat attcttccat tttccaatct cctttttgtt taggttaata tagattattt
    12061 taaattcttc tccctctgct ccacccagat caacttatcc acatcatacc ccctgcggat
    12121 ggcagcatcc agtaatttct tctttatctc ttccggcaga atgggcgtac ggctcaatat
    12181 ccacagatac ttgtccgaac tgctgccgat cagtacataa ttatactcct cctgatccaa
    12241 ctccaaaaca taatagtctg aataaaagga cagaaaaaag gataccttca gtttgcccgg
    12301 ttgcgacgaa tcgggaacct ttgcccgtcc ttccgctgtt ttacagacat catacggctt
    12361 tttatgctta catccccggt tctctacgcg aacggttccg tcgggcagca atatgtaagt
    12421 tgccgtcacc tccgacagtc cccgctcaaa gcggtggtcg aaacgggcta tctcgtacca
    12481 tgtacccata taacgttgca ggtccagttc gtccaccgta ctgtggtccg tgccctcaaa
    12541 aaaggcttcg atggtcggtt tatcaaagcg gaaacctgcc tcgagcaagc gtgtgggacg
    12601 cacattctgt cccgacgtta agaaggaagc cgcttcacca tattgcatcc gaaaaaacca
    12661 acgtggtatc accaccttca tccaggcatg atagcgcgct gccatcgccc gggtaaacgc
    12721 atattgtgaa acctgttgcg gaaccaccag attgaacact ccgcttaata cttcgtggtt
    12781 gatgatgaac tccatcgcac ggcaaagatc ctggattcca atccagggaa aaggctgtgt
    12841 gcccggagca atcacaccgg ctacccgtgt tatccgaagc ggacgcaaca tctgctccat
    12901 tgccccgcca tcgggtgaga gcactatgcc aaaacgggtg atagtcagcc ttgtctgtga
    12961 agggcaacgg cgagcctctt tctcccaggc gtagcaaagt tccgccaaga aaccgctgcc
    13021 gcgagtattg gtatattcgt caaacgttcc atcttccgga taatatccta cggcagaggc
    13081 ggaaatcatt aaccgcggct ttgtctttac cgcatccata gctcggatga tgcgatgcgt
    13141 caccttgata cggctgtcat aaagctcttt cttatactcc ggcgtccagc gtttactgat
    13201 gggtgctcct gccagattga ttactacatc gcaatgcgac aaggcctgaa ttaaatgtcc
    13261 cgatgtacct tcacgaaaca tgggtctccc cagagggact atccggtgcc ccctttccgt
    13321 aaggtactct gtaagatgct tgcctatgaa accggaggcc ccgctaattg ctatattcat
    13381 ctgaatctcc tttttttagg aatataacgc aggcaaagcg ggtaaagttc acctcatagt
    13441 catcttacgc aactcttcga gcgaaccgtt aaatacattc aaatctacat catggtgaat
    13501 accgggtaca cttccgatat ctgtatgctg ccagaaatgc cattttccct gatacttcac
    13561 cgagtcgaca tagtaatggg caatccagta gggataggca ttgaaaagcg aatcgtccag
    13621 atagtgagtt ttgaatttat atgaagtata gaggataggc ttcacaccat aatgtgcttc
    13681 cacccggtcg agccatttct tgatgctctg ttgcaactcc ttcttaggtt tcttgcctga
    13741 cagctccaca tcgagcaccg ggggaagatc gccactatcg agctttacgg tacggataaa
    13801 aaagtcagcc tgcttcaagg catccgtacg gggagtaaag aaatggtagg ccccacggat
    13861 aaagccatgc tggcgtgcct gttcaaagtt ttgcttgaag gtatcatcgc catggtcgcc
    13921 tccttcggtg gccttcataa aaataaagtg aagcgggaaa tcagtctcct tgttctgttt
    13981 cagttcctcc cagtcgatgt tcccctgata atgggaaata tcgataccat gcacttcgta
    14041 accacaagga atgcaaacgc catactcttt ccgcccgtag cattctttcc agcgatagga
    14101 ataaggacgg ataacgaaat agtaaaaagc aacagaaaac agaccgacaa caacgagcgc
    14161 aagggtgttg cgcaaccaaa caggcatggt acgggaggct ttctttttcg cttttctctt
    14221 ccgtaccgac gtatggcgac ggggagcggg tttattagaa acagaagtgg ttcgtgaaga
    14281 cttcattgat tgtattctta ttttgagttg gattcatttc taaatagtgc catcagcttc
    14341 cgccctgacc cattccagat aaatgcccgg attagcctct gctggaggag cgataaagtg
    14401 aacataacta attccgtttt gcgacttgtt tctgagtgga agacgcaggg accgaagccg
    14461 tccgtctacc cggacacgtg cctgcggacg tttctgagac aaatcccatt ccaaagaaac
    14521 ttcatgccaa cggtcatctt ttactcccag ttgcttgcgg gtcagaggaa gttcgtacat
    14581 cgattcatag cgggccacgg tgtccgaagg attcatccag cggtcattca gtaacaatga
    14641 aaccgaatgg cttccctccg gaatacgcag gctggcagtg aacgtccctt tcttcattgc
    14701 cgggaagttc cacactgccc cacgtgtatc tgctaccagc gaggcatcca gctgataaga
    14761 caaatggagc acctgacaac cctctttctc gggatgggat tcgagccggc acccctgtat
    14821 gcggttatag gcacaatgac ctttaatacc gtcgatataa ttgaatgtgc tccattgcga
    14881 aagagaatcg ctgaaattat taaaacggct tttctcgtac agccaattca cgtcgaacat
    14941 catcatggca cgatgaaggg gatgttgacc gatggatgcc agcaccttgc ccggagctac
    15001 ttctacaaac tgcgcctgat ggacaccacg gtcgattcca ccgccattga cagcataatc
    15061 ggagtcattg cgcatggggt ccatataaag ttcacgaaaa cctgtccacg tcttgccgtc
    15121 atcatcggac acagctacgt gagtcacgtc gcggttggtg aaaacatcat cccagacacc
    15181 attcgtccct tctttttcag gcagaggagt agtattgcac cagaaaagta acagtctacc
    15241 gtcggccaac ctgccaaggg tgggcatcgt gatagtaccg taaaaaggcg aaggttccga
    15301 ttcactccat gtcagaccgc catcttgcga gaaagcctga taatgccggt cctgtgaagt
    15361 acgcatcagc atccagagtg ttccgtcttt cagttcaacc acagtaggct ccacagcacc
    15421 gtgattccaa cgaatacctt tgtggaagcc tcctccccga tggtcgggcg aagtgactgt
    15481 attcgagcac ttccaggtca gtccgtcatc atcggaaacg taagtataac agcctttcgg
    15541 tgtcacgcct ccatgggcag ccaccacaat acgcttgccg ttcctgataa aaacgggtgg
    15601 tttaatcatg atggaactgc ggtcagccac tttcgtaagg gtacgtccgc ctgccagtcc
    15661 accggaagta cgaatgcaat aaacacccat cgcccccata tctaccaaac ggatatactc
    15721 tttgctcaca gggctttgac ggtctgcaaa aggcatctct ttagcccggt ttacccgttt
    15781 ccaggtcaga ccgtgatcgg cactcgacag ataaacggct cctgccactg cctgttctcc
    15841 atagttatag tgtcttactt caccattgtc aagaagcgac agaccgatat aagcatcgga
    15901 aggcggagta gctactttca aaggagcaca gaccgaatcg agcactaacg gacgggcttg
    15961 ctgcgcctgc cccgaaagga aaaaacctgc cgccagcagg catagagtag aaagtcgttt
    16021 catcatataa ataaggatat tcaaatgaac taaaaaccca ccgaagggaa ttgaatcaat
    16081 ccgccccgat gggtttctgt tattgtaatg cggagaacag cttacttagc ctgttccagt
    16141 tgcaatgtct tagtcggctg gtcgcaaact tctgtcggac cgaagtactg gatcggaccc
    16201 ggataaacgt agtctgtagt cagcgcccac tgatcgcgtt tggcagcaaa tgtcaggaac
    16261 ggtttgccat ccagtttcac caatgctttc tggattaccg gcttcatttc accgtgacga
    16321 cgttccatgt tcatcatcat cgtgataggc acaccgcctg cgatccattc ggcagcaggg
    16381 gcagttgtgt tgcgtactga tgacatgtaa ccggtcttac cgttggcaat cagcatagaa
    16441 gcggtataac ccagtgaata gcagtagtcg gcatcgtagt ttgacggagc agcgcaacgt
    16501 ccttcgtaac cgaagaagtg gtgctgtgca gcaaacttgc ctacgtattt gccttcttct
    16561 ttccactgag ccagtttcgt accaaccatt tcagacagca atttttctgt ttcgatcagt
    16621 gatacctgta cgtttccgtg cgggtcgcgg tccagagaaa gctgacgtgc cacaccttcg
    16681 ggaaggcttg catagatgtc agcattttct tttgacagct tgctgataat atattcacgc
    16741 tgacgagaac gtttgatgtt ggcgaactca actgcgttag cagccaggaa gtcgttcaac
    16801 tcagcgatca gacgtttcat agccgggata aattcaacca gaccttcagg aatcagcaca
    16861 gtaccgaagt tgtttccctg agcagcacgg tcagccacga tcttggcaat gtaagtcact
    16921 acatcatcca atgacatgtc ttttgcttct acttcttcag agatgataca tacattaggc
    16981 tgaacctgca aagcacattc cagtgcgatg tgagaagccg aacgtcccat cagtttgatg
    17041 aagtgccagt atttacgtgc tgagttacag tcgcgctgga tgttaccgat cacttccgag
    17101 tatactttac atgcagtatc aaaaccgaac gaagtttcga tcatgtcgtt tttcaagtca
    17161 ccgtcgatag ttttcgggca accaatcact tgtacaccgg cattctttgc agcataatat
    17221 tcagccagaa cacaggcatt tgtattggag tcgtcaccac caatgattac cagtgctttg
    17281 atacccagct tattgatgat ttccagaccc ttctcgaatt gttccggagt ttccagtttg
    17341 gtacgtcctg agccgatgat atcgaaacca ccggtgttgc ggtattcgtc aataatatcg
    17401 gcagtcagct ccatatagtt atggtcaacc aatccgccgg gacccaggat aaagccgtac
    17461 agcttattgt ctttgttcag tgttttgata ccgtcgaaca gaccagagat tacgttatgt
    17521 ccgcccggag cctgtcctcc tgaaaggata acacctacat tcatggcagg aagctggata
    17581 gcttcacctt cttcgaattt aatcaacggc attccgtaag tgttcgggaa cagtttctgg
    17641 atagcttcct ggtcggctac agattgtgta gctgcgcctt caactgcttt tactgagcct
    17701 ttcagcgctt tcggaagttt gggctggtaa gcagccctgg caatttgcaa tgcactttta
    17761 gtcattttct ttatcttata tttaaaggtg ttagtaattc gaacttaaaa gcgtcgcaaa
    17821 tttcgtgttt ttttccgaat tatgaaagaa aatggtgatt ttgttctctg cgggtatgcc
    17881 acagagcaaa cgaagggcac agagctaaaa tcaacgatct gaactctatg cccttcccgg
    17941 ctacttaaag gtatatctaa cttcctcttt aaaacgtcac cactgtcttg tcgcctgtag
    18001 cagagacggc atacactttg aagccgtcct tccaggctgt tttcatggta aacgtggcag
    18061 tatttgaggg tgctaatact ccatcggaga tacaaacctt tttacccgtt tcatccacta
    18121 cttcataagc taccacattt ttccaattgg tcatggtaaa tgtcgaaccg cttcgcgtag
    18181 ctgttccgga tattattccg ggtttggttt tatagagttc taccgaatta tcagttatat
    18241 actccaaagc aacatctggt ttcggatatc ccaaagcctc tacacgcttc tttatctcgt
    18301 cgatacggga ctgagtgaca gtaagttttc caactccata atcgtccaga gtgacatcta
    18361 tcggagtcag gaatccccat ttcgtgaaga aatccagcaa attggcttta gctatcaaac
    18421 tacagatata cacaaactca gtctgttgct ctccggcagt cttcaggtta tcgtgcgtac
    18481 gtatatattc gtatacatcc ggatagaatc ctcctttatc agcctgctga agcggtgtct
    18541 gcccaagcac tttgccgaaa taaagctcca gttgccagaa aggaacgagc ttgcagaaaa
    18601 catcactgtc actaccaaag tttccgtgag gagcacctgc cgcgatgatc tgggtccaag
    18661 ctttggaata tcggttccgg ctaccatctc ccatattttc tgtctgcagg cgtgaaggct
    18721 gcccgaaaat cgtagtctga atatactccg acataatatt attcgtcact tccgtagttc
    18781 ccagccattt caatccggga cgtgtctggt tgcaatgccc tatttcatgt gcaggccccc
    18841 agcatgaaga agttttcagt ttatccacat tacaaagttc cgccagtgta ccgtcattgt
    18901 acgcggtgtg ataactggtg gcatacatat agctggtata catcacatgc agatacatgc
    18961 ggtttttaaa caatttatta tacttataca gccccataag ttccatctcc gaattcacga
    19021 tctgatcata agcatcgatc aatacttttc cgtccggagt gtgagcacga aagcgctcgg
    19081 taggaaatgt gagatgtgca taatgtccca ccacatcaaa atacttatcg accgcattgc
    19141 tcaacaattt attccaatcg gaagcctgat gtttggctac atcgaaatac ccgttcacct
    19201 gtccggaagc aatgtgtatc tttacaggct gagctgtttc atagtcaggg gtgtgataca
    19261 aaatatacat caatccttta ttccgagccg taatcttgtt ggctccttca gacaacggat
    19321 agaaggtacc tccgaaaccg tcaccaccgg ggacgtcaag gttctgaatc actgcactga
    19381 taatttgccc gtgcgtatcg ccaaccaaca ccatcaactg ttccccgtct tttaccgaaa
    19441 ttcccgtagg attgtcgcgc aggctgtagg gactggtctt atgtgttttc gactgatcat
    19501 ccggattggg ccacgcttta taatcttgaa tacggaactc tgtcggatac ttaccttgct
    19561 tcatatagta agctatgttc ttgtagaatg aataaggaca gttttctatc tcttcatcgg
    19621 taagtccggg cttcagctca gaacaagtta catcagtgaa aagagtcaac gggtcaaatg
    19681 ctcccggatt ctttttataa aattccattt cggcacaggc cgcaaatccc tgtccgtctc
    19741 ccgaacctga ttttacaata aactgaacgg atgtgacgcc gatttgtgcc ttcggaaaat
    19801 taatacggac tgcagcattg gtacctccga agttcttagt cattacagta ttccattcat
    19861 cggcccctct ggtattcgca tttgacttca cacggatctc tacttccttg aagttaccat
    19921 tcggtcccga agtacgggga taatatataa aataatccat atccgaaccc gcagggaaat
    19981 tataagtcaa cgtgatagga aaataatgct ctcctgcgtt attccaatta gagtggtaaa
    20041 tagtactcat atctccatcg aatgatttat caatatttga gcctccctgg aaagaacttg
    20101 cctcgcccga ttctaccgga accttaatat cgtctttaat accttccata tctccggatt
    20161 catattctcc cagtcctttt tgagtaacag ataccagagc ctcaagctct ccacctacct
    20221 cttttacagt aatattgcca gtgcgttcac cgtcttcagg attggccgag acaatatatc
    20281 tatgtgttgt agtcaccatt tcggatgcac gcgtatccgc cggtttttct ttgacccatt
    20341 ccggcaatgt aatcgtcacc ggcacgtttg tagttacatc gaacgcaata tcacttccgc
    20401 tggcctcaac agtaaatgtc tgttgggata tcagaatagc aggatctgat cccaattggc
    20461 gtacgttaac agtttccgtc aatgcatcgg ca
//
