Select genomic region:
Overview
1.1
10.1
11.1
12.1
12.2
15.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAFKPO010000001.1 (Bacteroides fragilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | phosphonate | 184,160 | 197,719 |  |

NZ_JAFKPO010000003.1 (Bacteroides fragilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | cyclic-lactone-autoinducer | 187,155 | 207,646 |

NZ_JAFKPO010000004.1 (Bacteroides fragilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | RRE-containing | 16,335 | 36,688 |

NZ_JAFKPO010000005.1 (Bacteroides fragilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene-precursor | 207,425 | 228,399 |
Region 12.2 | phosphonate | 260,225 | 305,416 |  |

NZ_JAFKPO010000008.1 (Bacteroides fragilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | ranthipeptide,lanthipeptide-class-i | 87,885 | 123,484 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | phosphonate | 184,160 | 197,719 |  |
Region 10.1 | cyclic-lactone-autoinducer | 187,155 | 207,646 |
Region 11.1 | RRE-containing | 16,335 | 36,688 |
Region 12.1 | terpene-precursor | 207,425 | 228,399 |
Region 12.2 | phosphonate | 260,225 | 305,416 |  |
Region 15.1 | ranthipeptide,lanthipeptide-class-i | 87,885 | 123,484 |

No secondary metabolite regions were found in these records:
  NZ_JAFKPO010000010.1 (Bacteroides fragilis)
  NZ_JAFKPO010000011.1 (Bacteroides fragilis)
  NZ_JAFKPO010000012.1 (Bacteroides fragilis)
  NZ_JAFKPO010000013.1 (Bacteroides fragilis)
  NZ_JAFKPO010000014.1 (Bacteroides fragilis)
  NZ_JAFKPO010000015.1 (Bacteroides fragilis)
  NZ_JAFKPO010000016.1 (Bacteroides fragilis)
  NZ_JAFKPO010000002.1 (Bacteroides fragilis)
  NZ_JAFKPO010000006.1 (Bacteroides fragilis)
  NZ_JAFKPO010000007.1 (Bacteroides fragilis)
  NZ_JAFKPO010000009.1 (Bacteroides fragilis)

Compact view
NZ_JAFKPO010000001.1 - Region 1 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 184,160 - 197,719 nt. (total: 13,560 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
K5L50_RS00775: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.5 |  | 0.48 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000807.3 |  | 0.45 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000904.5 |  | 0.43 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0000751.3 |  | 0.43 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae
BGC0000754.3 |  | 0.43 | saccharide | capsular polysaccharide | Avibacterium paragallinarum
BGC0000755.3 |  | 0.43 | saccharide | capsular polysaccharide | Avibacterium paragallinarum 221
BGC0002670.2 |  | 0.42 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0001410.3 |  | 0.42 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000926.5 |  | 0.40 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000806.5 |  | 0.40 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.5 |  | 0.48 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000807.3 |  | 0.45 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000904.5 |  | 0.43 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0000751.3 |  | 0.43 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae
BGC0000754.3 |  | 0.43 | saccharide | capsular polysaccharide | Avibacterium paragallinarum
BGC0000755.3 |  | 0.43 | saccharide | capsular polysaccharide | Avibacterium paragallinarum 221
BGC0002670.2 |  | 0.42 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0001410.3 |  | 0.42 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000926.5 |  | 0.40 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000806.5 |  | 0.40 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.31 out of 25.88
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.15 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_JAFKPO010000003.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 187,155 - 207,646 nt. (total: 20,492 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
K5L50_RS08600: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: dehydratase
K5L50_RS08615: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000194.5 |  | 0.24 | PKS | actinorhodin | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000194.5 |  | 0.24 | PKS | actinorhodin | Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.16 out of 28.14
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.48 out of 23.79
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84
Confidence: medium
Additional weak hits (6):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 23.43
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.53 out of 29.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.39 out of 26.85
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.35 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator
PerR | Peroxide regulator

NZ_JAFKPO010000004.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 16,335 - 36,688 nt. (total: 20,354 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001838.4 |  | 0.32 | NRPS | WLIP | Pseudomonas putida
BGC0000503.5 |  | 0.30 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001588.3 |  | 0.29 | saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001412.3 |  | 0.27 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0001283.3 |  | 0.27 | PKS | Bisenarsan | Streptomyces lividans 1326
BGC0001589.3 |  | 0.27 | saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0002025.4 |  | 0.25 | NRPS, PKS | thaxteramide C | Jahnella sp. MSr9139
BGC0002432.2 |  | 0.25 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441
BGC0001093.3 |  | 0.24 | NRPS, PKS | disorazol A | Sorangium cellulosum
BGC0000080.5 |  | 0.22 | PKS | jerangolid A, jerangolid D | Sorangium cellulosum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001838.4 |  | 0.32 | NRPS | WLIP | Pseudomonas putida
BGC0000503.5 |  | 0.30 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001588.3 |  | 0.29 | saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001412.3 |  | 0.27 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0001283.3 |  | 0.27 | PKS | Bisenarsan | Streptomyces lividans 1326
BGC0001589.3 |  | 0.27 | saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0002025.4 |  | 0.25 | NRPS, PKS | thaxteramide C | Jahnella sp. MSr9139
BGC0002432.2 |  | 0.25 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441
BGC0001093.3 |  | 0.24 | NRPS, PKS | disorazol A | Sorangium cellulosum
BGC0000080.5 |  | 0.22 | PKS | jerangolid A, jerangolid D | Sorangium cellulosum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.55 out of 27.78
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.90 out of 28.19
Confidence: medium
Additional weak hits (3):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.59 out of 23.43
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.79 out of 24.78
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (16334...36688)
K5L50_RS10695
  RRE type: PqqD_RRE
  Location: 51 - 112
  Score: 35.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_JAFKPO010000005.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 207,425 - 228,399 nt. (total: 20,975 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
K5L50_RS13460: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

K5L50_RS13465: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthetase
K5L50_RS13490: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000650.3 |  | 0.38 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000667.3 |  | 0.37 | terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001911.3 |  | 0.37 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000643.3 |  | 0.35 | terpene | carotenoid | Brevundimonas vesicularis
BGC0001910.4 |  | 0.35 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000634.3 |  | 0.35 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5 |  | 0.34 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000650.3 |  | 0.38 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000667.3 |  | 0.37 | terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001911.3 |  | 0.37 | terpene | raimonol | Streptomyces anulatus
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000643.3 |  | 0.35 | terpene | carotenoid | Brevundimonas vesicularis
BGC0001910.4 |  | 0.35 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000634.3 |  | 0.35 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5 |  | 0.34 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
K5L50_RS13490: PT_FPPS_like
Domain 1 (28 - 323): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
Additional weak hits (2):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.06 out of 28.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.74 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_JAFKPO010000005.1 - Region 2 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 260,225 - 305,416 nt. (total: 45,192 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
K5L50_RS13835: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: acetyltransferase aminotransferase transferase
K5L50_RS13725: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

K5L50_RS13870: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

K5L50_RS13880: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

K5L50_RS13905: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase
K5L50_RS13720: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000794.5 |  | 0.51 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000790.3 |  | 0.51 | saccharide | O-antigen | Escherichia coli
BGC0001412.3 |  | 0.50 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0000791.3 |  | 0.50 | saccharide | O-antigen | Cronobacter sakazakii
BGC0002302.2 |  | 0.50 | saccharide | glucorhamnan | [Ruminococcus] gnavus ATCC 29149
BGC0000807.3 |  | 0.49 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001817.5 |  | 0.49 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000938.5 |  | 0.49 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000806.5 |  | 0.48 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001410.3 |  | 0.48 | saccharide | polysaccharide A | Bacteroides fragilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000794.5 |  | 0.51 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000790.3 |  | 0.51 | saccharide | O-antigen | Escherichia coli
BGC0001412.3 |  | 0.50 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0000791.3 |  | 0.50 | saccharide | O-antigen | Cronobacter sakazakii
BGC0002302.2 |  | 0.50 | saccharide | glucorhamnan | [Ruminococcus] gnavus ATCC 29149
BGC0000807.3 |  | 0.49 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001817.5 |  | 0.49 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000938.5 |  | 0.49 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000806.5 |  | 0.48 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001410.3 |  | 0.48 | saccharide | polysaccharide A | Bacteroides fragilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.33 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.12 out of 25.88
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.36 out of 28.19
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.74 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAFKPO010000008.1 - Region 1 - lanthipeptide-class-i,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 87,885 - 123,484 nt. (total: 35,600 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase sulfotransferase
K5L50_RS18610: Sulfotransferase domain

extras
  Sulfotransfer_2: Sulfotransferase domain

K5L50_RS18660: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Lyases: cyclase dehydratase
K5L50_RS18700: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

K5L50_RS18705: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Ligases: synthase
K5L50_RS18615: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002576.2 |  |  | 0.95 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0002640.2 |  |  | 0.72 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0002316.2 |  |  | 0.35 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0001289.5 |  |  | 0.33 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000507.5 |  |  | 0.31 | ribosomal | epicidin | Staphylococcus epidermidis
BGC0001727.3 |  |  | 0.31 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000556.5 |  |  | 0.29 | ribosomal | streptin | Streptococcus pyogenes
BGC0000541.5 |  |  | 0.28 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  |  | 0.28 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0002668.2 |  |  | 0.26 | ribosomal | cesin A | Clostridium estertheticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.77 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0002640.2 |  | 0.69 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0000754.3 |  | 0.51 | saccharide | capsular polysaccharide | Avibacterium paragallinarum
BGC0000755.3 |  | 0.51 | saccharide | capsular polysaccharide | Avibacterium paragallinarum 221
BGC0002316.2 |  | 0.49 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0001289.5 |  | 0.47 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000507.5 |  | 0.46 | ribosomal | epicidin | Staphylococcus epidermidis
BGC0001727.3 |  | 0.46 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000741.3 |  | 0.45 | saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000744.3 |  | 0.45 | saccharide | capsular polysaccharide | Streptococcus agalactiae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for K5L50_RS18695

K5L50_RS18715
Leader:
MKKLKKLTLKKETIAKLDQQ
Core:
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
Core with dehydrations:
N L Dha D L K G G Y Dhb Dhb Dha Dhb V Cys G N P Dhb Dhb E Dhb V A Cys L Dhb R G N Cys D I P Dhb I G H D D G P N Cys L Dha K Dha D Dha W Cys W Cys Y G I

#### antiSMASH-DB 4.0 matches for K5L50_RS18715

100.0%
NZ_CP018937.1 and 13 others:
NZ_CP018937.1 Lanthipeptides: BUN20_RS17050_lanthipeptide NZ_CP037440.1 Lanthipeptides: IB64_RS01195_lanthipeptide NZ_CP037440.1 Lanthipeptides: IB64_RS01195_lanthipeptide NZ_CP080296.1 Lanthipeptides: K0E65_RS01140_lanthipeptide NZ_CP080296.1 Lanthipeptides: K0E65_RS01140_lanthipeptide NZ_JADKYL010000013.1 Lanthipeptides: ISX59_RS17325_lanthipeptide NZ_JADKYL010000013.1 Lanthipeptides: ISX59_RS17325_lanthipeptide NZ_JADNBK010000016.1 Lanthipeptides: I2C48_RS13935_lanthipeptide NZ_JADNBK010000016.1 Lanthipeptides: I2C48_RS13935_lanthipeptide NZ_JAFKPO010000008.1 Lanthipeptides: K5L50_RS18715_lanthipeptide NZ_JAFKPO010000008.1 Lanthipeptides: K5L50_RS18715_lanthipeptide NZ_QRZH01000013.1 Lanthipeptides: DWW08_RS14950_lanthipeptide NZ_QRZH01000013.1 Lanthipeptides: DWW08_RS14950_lanthipeptide
Lanthipeptides: BUN20_RS17050_lanthipeptide
1
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
57
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
1
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
57
30.0%
NZ_CP120210.1:
Lanthipeptides: P3102_RS20315_lanthipeptide
2
L S D L K G-G Y T T S T V C G N P T T E-T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
L D K G Y V N T E T V L G I P T I D G + + S D
12
L L D A K G I E Y D Y I D V E A N T T A E E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
22.8%
NZ_CP007145.1:
Lanthipeptides: HSW_RS02435_lanthipeptide
2
L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D
32
L D+ G G T T+T P E A T G+C
1
L G D V V G G G T T N T C N N V P A Q E L E A I P T I G S C Q
31
with 11 more sequence matches
Only the first 10 are displayed here.
21.1%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: allorf_299950_300183_lanthipeptide
Lanthipeptides: allorf_299950_300183_lanthipeptide
16
G N P T T E T V A C L T R G N C D I P T I G----H D D G P
42
G P T V C R + P T+G D G P
10
G R P W T A R V P C P C R R S A A R P T V G V G G P E S D G P
40
18.6%
NC_021252.1 and 6 others:
NZ_CP008953.1 Lanthipeptides: AJAP_RS18050_lanthipeptide NZ_CP102415.1 Lanthipeptides: NQK81_RS00145_lanthipeptide NZ_JPLW01000002.1 Lanthipeptides: ED92_RS15140_lanthipeptide NZ_LIWC01000001.1 Lanthipeptides: AMK34_RS05315_lanthipeptide NZ_LQMT02000019.1 Lanthipeptides: AVR91_RS18555_lanthipeptide NZ_LT629789.1 Lanthipeptides: BLU53_RS08165_lanthipeptide
Lanthipeptides: AORI_RS61605_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
33
E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_BNAY01000001.1:
Lanthipeptides: IE302_RS05625_lanthipeptide
17
N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
N E V L G I P T I D G + + S D
29
N G A E E I V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP017780.1:
Lanthipeptides: BKN51_RS13855_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R G L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP024972.1 and 2 others:
NZ_LQCI01000009.1 Lanthipeptides: AVL48_RS10805_lanthipeptide NZ_MQUQ01000028.1 Lanthipeptides: BS329_RS37485_lanthipeptide
Lanthipeptides: CVV72_RS07560_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP092497.1:
Lanthipeptides: MJQ72_RS07465_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R A L Q N G E R R I P T I V W P D G S H L V E P S D
61
17.1%
NZ_CP016174.1:
Lanthipeptides: SD37_RS21180_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
31
A E E A V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
17.1%
NZ_KB913032.1:
Lanthipeptides: AMYAL_RS0133590_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
33
E I V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
17.1%
NZ_MUXN01000027.1:
Lanthipeptides: B0293_RS35050_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
33
E I V R A L Q N G A R R I P T I V W P D G T H L V E P S D
61
15.8%
NZ_JNJB01000019.1:
Lanthipeptides: Q369_RS0119815_lanthipeptide
35
T I G H D D G P N C--L S K S D S W C W C Y G
56
T G D+G P+C + K+ ++ C G
7
T A G G D N G P S C C G I G K T S T Y T S C A G
30

#### MIBiG 4.0 matches for K5L50_RS18715

10.5%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
K G G Y T T S T V
14
K G Y T T V
13
K G A Y C T L T V
21
8.8%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
7
G G Y T T S T V C G N P T T E T V A C
25
G + V C + V C
2
G S Q V S L L V C E Y S S L S V V L C
20
8.8%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
16
G N P T T E T V A
24
P T T V A
1
A T P A T P T V A
9

#### Lanthipeptide(s) for K5L50_RS18700

K5L50_RS18715
Leader:
MKKLKKLTLKKETIAKLDQQ
Core:
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
Core with dehydrations:
N L Dha D L K G G Y Dhb Dhb Dha Dhb V Cys G N P Dhb Dhb E Dhb V A Cys L Dhb R G N Cys D I P Dhb I G H D D G P N Cys L Dha K Dha D Dha W Cys W Cys Y G I

#### antiSMASH-DB 4.0 matches for K5L50_RS18715

100.0%
NZ_CP018937.1 and 13 others:
NZ_CP018937.1 Lanthipeptides: BUN20_RS17050_lanthipeptide NZ_CP037440.1 Lanthipeptides: IB64_RS01195_lanthipeptide NZ_CP037440.1 Lanthipeptides: IB64_RS01195_lanthipeptide NZ_CP080296.1 Lanthipeptides: K0E65_RS01140_lanthipeptide NZ_CP080296.1 Lanthipeptides: K0E65_RS01140_lanthipeptide NZ_JADKYL010000013.1 Lanthipeptides: ISX59_RS17325_lanthipeptide NZ_JADKYL010000013.1 Lanthipeptides: ISX59_RS17325_lanthipeptide NZ_JADNBK010000016.1 Lanthipeptides: I2C48_RS13935_lanthipeptide NZ_JADNBK010000016.1 Lanthipeptides: I2C48_RS13935_lanthipeptide NZ_JAFKPO010000008.1 Lanthipeptides: K5L50_RS18715_lanthipeptide NZ_JAFKPO010000008.1 Lanthipeptides: K5L50_RS18715_lanthipeptide NZ_QRZH01000013.1 Lanthipeptides: DWW08_RS14950_lanthipeptide NZ_QRZH01000013.1 Lanthipeptides: DWW08_RS14950_lanthipeptide
Lanthipeptides: BUN20_RS17050_lanthipeptide
1
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
57
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
1
N L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D S W C W C Y G I
57
30.0%
NZ_CP120210.1:
Lanthipeptides: P3102_RS20315_lanthipeptide
2
L S D L K G-G Y T T S T V C G N P T T E-T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
L D K G Y V N T E T V L G I P T I D G + + S D
12
L L D A K G I E Y D Y I D V E A N T T A E E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
22.8%
NZ_CP007145.1:
Lanthipeptides: HSW_RS02435_lanthipeptide
2
L S D L K G G Y T T S T V C G N P T T E T V A C L T R G N C D
32
L D+ G G T T+T P E A T G+C
1
L G D V V G G G T T N T C N N V P A Q E L E A I P T I G S C Q
31
with 11 more sequence matches
Only the first 10 are displayed here.
21.1%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: allorf_299950_300183_lanthipeptide
Lanthipeptides: allorf_299950_300183_lanthipeptide
16
G N P T T E T V A C L T R G N C D I P T I G----H D D G P
42
G P T V C R + P T+G D G P
10
G R P W T A R V P C P C R R S A A R P T V G V G G P E S D G P
40
18.6%
NC_021252.1 and 6 others:
NZ_CP008953.1 Lanthipeptides: AJAP_RS18050_lanthipeptide NZ_CP102415.1 Lanthipeptides: NQK81_RS00145_lanthipeptide NZ_JPLW01000002.1 Lanthipeptides: ED92_RS15140_lanthipeptide NZ_LIWC01000001.1 Lanthipeptides: AMK34_RS05315_lanthipeptide NZ_LQMT02000019.1 Lanthipeptides: AVR91_RS18555_lanthipeptide NZ_LT629789.1 Lanthipeptides: BLU53_RS08165_lanthipeptide
Lanthipeptides: AORI_RS61605_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
33
E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_BNAY01000001.1:
Lanthipeptides: IE302_RS05625_lanthipeptide
17
N P T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
N E V L G I P T I D G + + S D
29
N G A E E I V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP017780.1:
Lanthipeptides: BKN51_RS13855_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R G L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP024972.1 and 2 others:
NZ_LQCI01000009.1 Lanthipeptides: AVL48_RS10805_lanthipeptide NZ_MQUQ01000028.1 Lanthipeptides: BS329_RS37485_lanthipeptide
Lanthipeptides: CVV72_RS07560_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
18.6%
NZ_CP092497.1:
Lanthipeptides: MJQ72_RS07465_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E T V L G I P T I D G + + S D
31
A E E T V R A L Q N G E R R I P T I V W P D G S H L V E P S D
61
17.1%
NZ_CP016174.1:
Lanthipeptides: SD37_RS21180_lanthipeptide
19
T T E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
31
A E E A V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
17.1%
NZ_KB913032.1:
Lanthipeptides: AMYAL_RS0133590_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
33
E I V R A L Q N G E R R I P T I V W P D G T H L V E P S D
61
17.1%
NZ_MUXN01000027.1:
Lanthipeptides: B0293_RS35050_lanthipeptide
21
E T V A C L T R G N C D I P T I G H D D G P N C L S K S D
49
E V L G I P T I D G + + S D
33
E I V R A L Q N G A R R I P T I V W P D G T H L V E P S D
61
15.8%
NZ_JNJB01000019.1:
Lanthipeptides: Q369_RS0119815_lanthipeptide
35
T I G H D D G P N C--L S K S D S W C W C Y G
56
T G D+G P+C + K+ ++ C G
7
T A G G D N G P S C C G I G K T S T Y T S C A G
30

#### MIBiG 4.0 matches for K5L50_RS18715

10.5%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
K G G Y T T S T V
14
K G Y T T V
13
K G A Y C T L T V
21
8.8%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
7
G G Y T T S T V C G N P T T E T V A C
25
G + V C + V C
2
G S Q V S L L V C E Y S S L S V V L C
20
8.8%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
16
G N P T T E T V A
24
P T T V A
1
A T P A T P T V A
9

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

K5L50_RS18715 - Class I
  Cleavage pHMM score: -11.90
  RODEO score: 19
  Monoisotopic mass: 5804.7 Da
  Molecular weight: 5808.4 Da
  Number of bridges: 6
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5826.4 Da N = 1
    5844.4 Da N = 2
    5862.4 Da N = 3
    5880.5 Da N = 4
    5898.5 Da N = 5
    5916.5 Da N = 6
    5934.5 Da N = 7
K5L50_RS18715 - Class I
  Cleavage pHMM score: -11.90
  RODEO score: 19
  Monoisotopic mass: 5804.7 Da
  Molecular weight: 5808.4 Da
  Number of bridges: 6
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5826.4 Da N = 1
    5844.4 Da N = 2
    5862.4 Da N = 3
    5880.5 Da N = 4
    5898.5 Da N = 5
    5916.5 Da N = 6
    5934.5 Da N = 7

RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (87884...122283)
K5L50_RS18700
  RRE type: Lanthipeptide_LanB_RRE
  Location: 145 - 221
  Score: 34.2
lanthipeptide-class-i protocluster (92429...123484)
K5L50_RS18700
  RRE type: Lanthipeptide_LanB_RRE
  Location: 145 - 221
  Score: 34.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---