LOCUS       NZ_CP080647            21164 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces akebiae strain MG28 chromosome, complete genome.
ACCESSION   NZ_CP080647
VERSION     NZ_CP080647.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces akebiae
  ORGANISM  Streptomyces akebiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10257202)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2021) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019599145.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:26:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,127
            CDSs (total)                      :: 9,036
            Genes (coding)                    :: 8,727
            CDSs (with protein)               :: 8,727
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 142 of 309
            Pseudo Genes (incomplete)         :: 231 of 309
            Pseudo Genes (internal stop)      :: 20 of 309
            Pseudo Genes (multiple problems)  :: 77 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9372083
            Orig. end                         :: 9393247
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP080647.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21164
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="30"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21164
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21164
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11164](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11164)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    171..187
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            complement(366..1703)
                     /locus_tag="K1J60_RS40605"
                     /old_locus_tag="K1J60_40605"
     CDS             complement(366..1703)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004985329.1"
                     /locus_tag="K1J60_RS40605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40605"
                     /product="hemolysin family protein"
                     /protein_id="WP_220650580.1"
                     /transl_table=11
                     /translation="MTEIVLLLLALLLTLACAVFVAAEFSLTTVERGELERATEAGERG
                     AEGALKAVRRLTLQLSGAQLGITVTSLVIGMLAEPSLAALLRGPLQAVGLGGAASSVAT
                     VLGVAVSTVVLMVVGELVPKNWAISRPLAVAKVVAGPQRGFTAAFGPFIRHLNSTANRF
                     VRRFGLEPAEELASARGPEELVALAQHSAAEGALEADSAELFVRTLHLSELTAENVMTP
                     RVDVRALEAHATAADAANLTYATGLSRFPVYRDSLDEVIGTVHIRDVLALEPEKRALTP
                     VTELATAPLLVPDSLTADRLLERLRETRTMAVVIDEYGGTAGVATVEDIVEEVVGEVRD
                     EHDPVEVPDLLPAARTGDGRAVWEADGSVRIDELARIGLTAPEGPYETVAGLVATRLAR
                     IPAKGDDLDLDDGWRLHVLDVDHHRAGRVRITAPVRMPVQAAEESR"
     misc_feature    complement(1834..1850)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            2106..2324
                     /locus_tag="K1J60_RS40610"
                     /old_locus_tag="K1J60_40610"
     CDS             2106..2324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606563.1"
                     /locus_tag="K1J60_RS40610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40610"
                     /product="hypothetical protein"
                     /protein_id="WP_220650581.1"
                     /transl_table=11
                     /translation="MASIDLDEVLDKAWTDKSLPEILAAPVGALKGVSDRDGELLQEAF
                     GVKSIADLAELKYVRWAQALAALDTAR"
     misc_feature    2223..2225
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2418..3410
                     /locus_tag="K1J60_RS40615"
                     /old_locus_tag="K1J60_40615"
     CDS             2418..3410
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670271.1"
                     /locus_tag="K1J60_RS40615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40615"
                     /product="sporulation protein"
                     /protein_id="WP_220650582.1"
                     /transl_table=11
                     /translation="MVFKRLLGSLGVGGPTLDTVLDPGAALPGGALSGRVHLKGGNADF
                     DIEHITLELVARVEAEHEEGESAGAVVFDRFTVGGGFRLAEGEERNVPFSVTLPWETPV
                     TELYGQGLGIVLGVRTELSVAGAKDKGDLDQMAVGPLPVQEAILEALGQLGFGFKSADL
                     ELGRIGGTGQQLPFYQELELTPPPQYAHQVNEIEVTFLATPGGMEVVLEADKRGGLFSS
                     GHDALTRFTVGHHDVRDWNTEVDGWIRQLVEHRASYGSHAAYGHGDPHASGGHDDHHQD
                     SHHRSGPGMGTVVAAGAAGLAVGVVGGMVAAEVVDEVGDFFEGDEEEEG"
     gene            complement(3770..4702)
                     /locus_tag="K1J60_RS40620"
                     /old_locus_tag="K1J60_40620"
     CDS             complement(3770..4702)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313596.1"
                     /locus_tag="K1J60_RS40620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40620"
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_220650583.1"
                     /transl_table=11
                     /translation="MGVFVFLPLVLPLTAWPIARLAEQRLHPRTATRLLTAVAVVMAVC
                     STVCLGLLMVVGTAQLPGNPLPDAWSDPEVREAVPHDEVAGKLAIPALLAVLLTCCRTL
                     WRHGRVLHRAHRALAGLPGTEVAVLPDEVPYAYALPGGRRGRVVVTTALLSCLEPAERR
                     ALFAHERAHLAARHHRFLLAVQLAARANPFLRPLRTAVAYMAERWADEDAAQAVGSRRA
                     VACAIGKAALVSRGTPVPTLGGFAAPGPVPRRVAALLGPAPAMRSWPSVFTSVGLAAWG
                     AAAGTAVSALSSANSAVTMVLILHAATPL"
     gene            complement(4709..5098)
                     /locus_tag="K1J60_RS40625"
                     /old_locus_tag="K1J60_40625"
     CDS             complement(4709..5098)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132263.1"
                     /locus_tag="K1J60_RS40625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40625"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_220650584.1"
                     /transl_table=11
                     /translation="MTDQRQRPPRRGQGELEALVLSALREADSPVNAGWVHERVGGDLA
                     YTTVVTILTRLLAKGAVARERTGRSFAWTPASDQAGLAAHKMRKVLDAESDREAVLASF
                     VTSLEPDDERLLRELLGRAKDERED"
     misc_feature    5895..5910
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(5963..5976)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            6192..6557
                     /locus_tag="K1J60_RS40630"
                     /old_locus_tag="K1J60_40630"
     CDS             6192..6557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970905.1"
                     /locus_tag="K1J60_RS40630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40630"
                     /product="hypothetical protein"
                     /protein_id="WP_220650585.1"
                     /transl_table=11
                     /translation="MDTHTSRPRPLRQVTATAGATGSALAVALLPLVVGALVARAAGAD
                     PMASVNALIAGGGERAKLSRSHLPVLRGMGSAPRRVGARLARTRPPEGRPAGRLRGRRL
                     LAGREDVRVEVPDRRER"
     gene            complement(6501..7904)
                     /locus_tag="K1J60_RS40635"
                     /old_locus_tag="K1J60_40635"
     CDS             complement(6501..7904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474910.1"
                     /locus_tag="K1J60_RS40635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40635"
                     /product="phospholipase"
                     /protein_id="WP_259408129.1"
                     /transl_table=11
                     /translation="MSQIRPRPRPRPRSRRRVRARALCAVASLALGVPVAFSGPAAAAV
                     PTYSVYLQNSVTGLNAADNGGTVAAHNPKGNEDHQQWTPVAVTGGHQLRSADQSGICLG
                     RGGTSAVTAACGADGTTWTVTEAANSTYTIGVPGTSQYLTGTSSDPSLVQLGSSGAYAR
                     WHLTPVSYATSAMPSADTRTLDQVSFLTSHNAYANGVDGNFASFPVSLFPNQARGVSRQ
                     LTDGVRGFMLDAYTVSGQAMLCHNSCDGVSNPVPLATDLQHMVTFLKANPGQFVTVFLE
                     DYTASDVLKSSLASVSGLSDVLYRPDQEGVATSGWPRMADLAARGKQLLIFSDRTRASD
                     TSAGYVTRDTFGVMYQREWTVENHWSMGGGLGGSDWSCYSRWGTARPLTTDSAAFHPLF
                     VMNHFRDYTISGTAETDNAKLGNRAQNFCTPAARKKPNYLAVDRYELGSPSPLTTVGNL
                     NTYVLTAGQ"
     gene            8132..9139
                     /locus_tag="K1J60_RS40640"
                     /old_locus_tag="K1J60_40640"
     CDS             8132..9139
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386733.1"
                     /locus_tag="K1J60_RS40640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40640"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_220650586.1"
                     /transl_table=11
                     /translation="MSEPTASVCPQCGTPRATDGTPACSCGRLASEAHRDVRAAQAEAA
                     EDFDPVRIRPFVQVGDDGEPQATPPTGEVPPTAGDDGQAPTDAQPPTEARIPTDAQAPV
                     DAQAVGEDRAMPDERDAGGAHTGGDAPRSDGRDAGGKRRRRVALAAGVGAAAAAVLVTA
                     GIIGGLFSYEAPSRDGSGPDDIRAGLPEAAEGQEASRSATPSPTGSTASPSGSATTSPA
                     ATPTETGATPAPSTSMTKVPSGSDATVTAAPAPPVTDGPPPVLGLGDQGAEVTELQLRL
                     RQIGFYNGDPDGDYDREVQSAVRGYQLTRVLLEDESGVYGEATRAALESETSEP"
     gene            complement(9173..9454)
                     /locus_tag="K1J60_RS46425"
     CDS             complement(9173..9454)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS46425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="tol-pal system YbgF family protein"
                     /protein_id="WP_259408130.1"
                     /transl_table=11
                     /translation="MWEPGRSALCEDACGWVAYRQGRLEESVDLLQDAVEHSGGHARQW
                     AHLALALEARDDPEGVDRARDMWQQIAEQFPHSDTAGQARRHLAAAAA"
     gene            complement(<9647..9937)
                     /locus_tag="K1J60_RS40650"
                     /old_locus_tag="K1J60_40650"
                     /pseudo=""
     CDS             complement(<9647..9937)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326603.1"
                     /locus_tag="K1J60_RS40650"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40650"
                     /product="SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDPGTTTTAPQPPRSTEPCPARSVYQNRVADHWNAEENPVHLELG
                     EIDDLYHHHHGIGEADWSVLDDDPEPARRRARVTAELHRLEQAQAEPPAGHL"
     gene            complement(10001..11164)
                     /locus_tag="K1J60_RS40655"
                     /old_locus_tag="K1J60_40655"
     CDS             complement(10001..11164)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007501744.1"
                     /locus_tag="K1J60_RS40655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40655"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_220650587.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-53, bitscore: 182.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEPSVAGAPSRDRPPEPPGSAPTWPPETPSSARARPPVQSSRAR
                     TRLPGPPSPARARRARRSGAVPGLRHRPAVPADPARAAEVDRRLESWAERLDLFPSTWR
                     GQFARFGLGRAIVLAHPGGAGLEHLTAAGKLLLAEHLVDNVYCEVDEGKGGSPRGLGGR
                     LLMAQSALDPLHTTPGTEEGWRRGVRADGPLRSYHFALGDYAALATPSQTDRLVHDLAR
                     LHLGYLGEAAWAETDHMPQVWEYLVMRQFNNFRPCLSVVDAVDGWELPEHLYARPEVQR
                     ITALAGNAATIVNDLYSFTKELSNDPGHLNLPVVIAANERCGLKAAYLRAVEIHNRIME
                     AFEEESAALSATSPPIERYATGLAAWVAGNHEWHATHTDRYSLPDYW"
     gene            complement(11161..12588)
                     /locus_tag="K1J60_RS40660"
                     /old_locus_tag="K1J60_40660"
     CDS             complement(11161..12588)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005613.1"
                     /locus_tag="K1J60_RS40660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40660"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_220650588.1"
                     /transl_table=11
                     /translation="MTAPVSSSESAPEPADEQHFTSLSTRAARQLATTTKSEPQMQAIT
                     SRWLLRTLPWVDVKGGTFRVNRRLQLRIGRGRVQFDQNGADDVKVIPETLTELPALRGY
                     ADLPALREISARFRVREVRAGQVLVDAGQPVTEAYLVVHGRFTRYTTGKYGEEEVLGVI
                     SDGDGLGDEAIGHADPLWLSSVRADTAGVVLALNWDVLMAFVERTPSLAAQFDAFAEQQ
                     RRPMNRKGEADVPLEAGHVGELTLPGGFVDYDLAPREYELSLTQTVLRVHTRVADLYNN
                     PMDQTEQQLRLTIEEIRERQEWELVNNRDFGLLHNIDYGQRISTFSGPPTPDDMDELLS
                     MRRRTRLCLAHPKAIAAFFRQCNRRGLVPGTVNVEGHEMPAWRGVPLLPCSKIPITPQH
                     TTSIIALRTGEKDQGVVGLHQTGIPEEYEPSLNVRFMGVDATAIMSYLVTAYYSMAVLV
                     PDAAGILENVQVGWMPE"
     gene            complement(13069..14328)
                     /locus_tag="K1J60_RS40665"
                     /old_locus_tag="K1J60_40665"
     CDS             complement(13069..14328)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326608.1"
                     /locus_tag="K1J60_RS40665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40665"
                     /product="glucarate dehydratase family protein"
                     /protein_id="WP_220650589.1"
                     /transl_table=11
                     /translation="MTGTPGSRIRELIVTPIAFRDPPLLNSGGVHEPLALRTVLQLVLE
                     DGTVGLGESTGGTVRLERLDIAAKAVVGLDVFDTTAVTAAIDTALRPTVPGSHERGWTT
                     SAVEVACLDAQGRLLGRPVSDLLGGRVRDTVPFAAYLFYKWAEHPALDGRPAVGDDWGE
                     ALDPAGVVEQARLMQQRYGFRSFKLKGGVFPPDEEIAAVEALAEAFPGQPLRLDPNTAW
                     TVETSKYVARRLDGVLEYLEDPTAGIPGMAEVAEESPMPLATNMCVVAWEHLRPAVEQD
                     AVQVLLTDHHYWGGLRRTRELAAVCEAFGLALSMHSNSHLGISLAAMTHVAAAIPNLDH
                     SCDTHYPWNSADDVIVPGVLEFRNGEVAVPTGPGLGVELDHDALDRLHRLYVDSGMCSR
                     DDTGYMRRIQPGYELRLPRW"
     gene            complement(14378..15451)
                     /locus_tag="K1J60_RS46430"
     CDS             complement(14378..15451)
                     /EC_number="4.2.1.41"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716188.1"
                     /locus_tag="K1J60_RS46430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5-dehydro-4-deoxyglucarate dehydratase"
                     /protein_id="WP_259408132.1"
                     /transl_table=11
                     /translation="MKFQGVLFFPVTPFAPDGSLDEERLAQHIEAGVAAGAGGVFVACG
                     TGEFHALTSEEIERATRIAVATTAGRVPVLAAAGGPPPVARDQAARVERAGADGILLLP
                     PYLVSAPQQGLIRYVKEVTEATALPVVFYQRGTARLTPDTAAAIAALPGVVGLKDGIGD
                     IERMHRVVRAVRAVPGTEGFQFFNGLPTAEMIAPAYQGIGVGLHSSAVFAFAPEIAVAF
                     HRALVPRQATFAPSQRPARTLAAPGTSPSTSSTRTFARHAESTHRTPLLDGQRLPAAAL
                     AEHDETLVATLLDEFYGPLVELRDEVPGYAVALVKAGVTLRGLDVGGVRAPLVDPTPEH
                     VARLAKLIDHGLEVVGA"
     misc_feature    complement(15727..15742)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            15830..16699
                     /locus_tag="K1J60_RS40680"
                     /old_locus_tag="K1J60_40680"
     CDS             15830..16699
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525587.1"
                     /locus_tag="K1J60_RS40680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40680"
                     /product="fructosamine kinase family protein"
                     /protein_id="WP_259408133.1"
                     /sec_met_domain="APH (E-value: 1.2e-11, bitscore: 44.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGERTAPSALAARFTGRPTTGERRLSGTLTEVTLDDGRKVLVKVG
                     DGPGAARAEAAGLRWLAEADTVRVPTVHGHHGNRLVIDLVDQGAPSAGAAARLGAELAA
                     LHGAGAPAFGAPPPGGPREAYIGRAPMRNVPVPGGDWPAWYAEHRVLPYLRRAVDDRTI
                     RPAEATLIEEVCARLPDLAGPAEPPARLHGDLWNGNVLWGADGRARLIDPAAHGGHRET
                     DLAMLALFGCPHLGHVLDGYQRAAPLADGWQDRVGLHQLFPLLVHTVLFGRGYAEQALA
                     VARAALGK"
     gene            complement(16869..19040)
                     /locus_tag="K1J60_RS40685"
                     /old_locus_tag="K1J60_40685"
     CDS             complement(16869..19040)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992803.1"
                     /locus_tag="K1J60_RS40685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40685"
                     /product="TerD family protein"
                     /protein_id="WP_220650591.1"
                     /transl_table=11
                     /translation="MAQSLESLVVRHTHRLPVPKGSAGDGTAAARQFDAALMDVGFKLS
                     AELLQRLSGLSEAAVLHTARRTLRTVREMVGDHVRHNSYFIDFPANVPGTEEFWTRCVA
                     RALGDEKAREGVLTQLANGVLDLLSLPTYGRYQHTYEEMLAAQDELIASAGDRITVLHP
                     GRDLDHELTDLYLALAGSTTPLGEDDLRDLGVLAERCALGPQPERIPVRENRAVVNEAR
                     LTAGADLLLDTVTDVLRLACALSGGDVTLQEPTRFRSLSRPVRRALLAGLDAVVAANPA
                     KLADVHAHREPFKRLGERLHPHEYPRWPHAADVFAVARGEKEARSFDSRVEKLLDEFDV
                     TGAAGLLKAAPGRLFRTLDLLLRIAADQAERDAVLAAAVEVAPEVSGRVVLSVREHLHN
                     RERETDAPRVFVNRRGRAWVSPDDRPPVPAAERDRLIAALDTEIGRRLPEPGRLLVDPD
                     VLDVALPLSGRATAAGLGVLPRGSVSEVDGERLRFFVYWKETEHRTDYDLSALLLHSDY
                     STDSWLSYTSLTAVGGRHSGDVTEAPDGASEFIELSLDRVRGTFIVPQVNIYAGEGFEE
                     VEESFFGFMVRDGAQKGRPFEPRTVRMKSELRGVGRVALPLAFRRGEDGRWRAKWLHLY
                     LKGISSANRVEENQASVSKVVRAVVEREQLTVGYLIDLMTREGTVMDLWDGTWVPDEPV
                     TYIGLERPEGLHPDSRIITLENLRDLVPG"
     misc_feature    complement(19652..19665)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            19684..20670
                     /gene="paaA"
                     /locus_tag="K1J60_RS40690"
                     /old_locus_tag="K1J60_40690"
     CDS             19684..20670
                     /GO_function="GO:0097266 - phenylacetyl-CoA 1,2-epoxidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="K1J60_RS40690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40690"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_220650592.1"
                     /transl_table=11
                     /translation="MTTTDSAGAPSQDAEDALQQHFDATIARDQRIEPRDWMPDGYRRT
                     LVRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RADLTRRLIEGRQKYSSIFNYPTASFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQRAMVQDAVNRWWWPSLMMFGPPDDASPNSAQ
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEERGRHDFGTPDWDELKR
                     VISGDGPCNDRRMERRRTAHEDGAWVREAATAHAAKRDERARKGTAA"
     gene            20667..20963
                     /gene="paaB"
                     /locus_tag="K1J60_RS40695"
                     /old_locus_tag="K1J60_40695"
     CDS             20667..20963
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326309.1"
                     /locus_tag="K1J60_RS40695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_40695"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_086785833.1"
                     /transl_table=11
                     /translation="MTGTNKGDWPLYEVFVRGKRGLNHVHVGSLHAADDQMALTHARDL
                     YTRRNEGVSLWVVRSEHIAASTRDEKDPFFEPSADKVYRHPTFYDIPDDVPHI"
ORIGIN
        1 cgggatcatc tcgccgatca gcatgtgcag gtacgtcgcc aggctgagcg cgatgacgaa
       61 cgcgatcgga tgcaccaggc cgtgcgggat gtgggccgcc tcgaaagcgg gctccagcag
      121 atgggcgatg gccggttcgg cgaccgcgcc gagcaccagc gaggagacgg tgatgccgaa
      181 ctgggcagtg gccatcagcg ccgagaggtg ctccaggccc cacaacgtca tccgggcccg
      241 cttgtcaccc tccttcgccc gcggctcgat ctgtccgcga cgcacggaga tcagggcgaa
      301 ctccccgccc acgaagaagg cgttggtcag cagggtcagg gcaccgatgg tgagttgcag
      361 tacggtcatc gggactcctc cgccgcctgg accggcatcc ggaccggcgc ggtgatgcgg
      421 acgcggccgg cgcggtggtg atcgacgtcg aggacatgaa gtcgccagcc gtcgtcgagg
      481 tcgaggtcgt cgcccttggc cgggatgcgc gcgaggcggg tggcgaccag cccggccacg
      541 gtctcgtacg ggccctccgg cgccgtcaac cctatccggg ccagctcgtc gatgcggacc
      601 gagccgtccg cctcccacac cgcacgcccg tcccccgtcc tcgccgcggg cagcagatcg
      661 gggacctcga cggggtcgtg ctcgtcacgg acctcgccga cgacctcctc gacgatgtcc
      721 tccaccgtcg ccacccccgc ggtaccgccg tactcgtcga tgaccacggc catcgtgcgc
      781 gtctcgcgca gccgctccag cagccggtcg gcggtgaggc tgtccggcac cagcagcggg
      841 gcggtggcca gctcggtcac cggagtgagg gcccgcttct ccggttccag ggcgagcacg
      901 tcgcggatgt ggacggtgcc gatgacctcg tccaggctgt cgcggtagac agggaagcgg
      961 gacaggccgg tggcgtacgt caggttcgcc gcgtcggccg ccgtggcgtg ggcctccagc
     1021 gcccggacgt cgacccgcgg ggtcatcacg ttctcggccg tgagctcact caggtgcagg
     1081 gtgcgcacga acagctcggc ggagtccgcc tccagggcac cttcggctgc cgagtgctgg
     1141 gcgagcgcga ccagttcctc gggcccgcgg gcggaagcca gctcctcggc cggctccagg
     1201 ccgaagcgcc ggacgaaccg gttcgcggtg ctgttcaggt gccggatgaa cggcccgaag
     1261 gcggccgtga agccgcgctg cgggcccgcg accaccttgg cgaccgccag cggccgggag
     1321 atcgcccagt tcttcggcac cagttcgccc accaccatca ggaccacggt ggagacggcc
     1381 acgcccagca cggtcgccac ggacgacgcg gcgccgccca ggccgaccgc ctgaagcggg
     1441 ccgcgcagca gcgcggcgag ggacggctcg gcgagcatgc cgatcaccag cgaggtgacg
     1501 gtgatgccca gctgggcacc ggagagctgg agagtcagac gccgtacggc cttcagcgcg
     1561 ccctcggcgc cgcgctcgcc cgcctcggtg gcacgctcca gctcaccgcg ctcgacggtg
     1621 gtcagcgaga actcggccgc gacgaacacc gcgcaggcca gcgtcagcag cagagcgagc
     1681 aggagcagca cgatctcggt caccgtgaca cccccgctcc ctcattcaca tgggtcaggc
     1741 ggggcgtggc acggctggta ctgggaggct cacccatcgg gggaccgtcg ctccttctca
     1801 agacgtgtgg gatgacagtg ggggaagcag gattgcctgc ttctacacca actgtaaagg
     1861 agccgcaaag aacctcaccc ggccagggcc tccggtttca ggcgttccgg gtggcgcacc
     1921 ctccggccgc gccgagcctg agtatcgccc tccggccggc acaggaacca gttttcggcc
     1981 tttcccgccg cgtccgcgcg gacagtgccc ttccccgctc ccggcagctc tatacttcta
     2041 cacgtttgta gaaggtccga gcgtgagccg ggccccgcac gcatgcacgt tgggagacga
     2101 cacgtatggc ttcgatcgac ctggacgagg tgctggacaa ggcatggacg gacaagagcc
     2161 tgcccgagat cctggcggcc ccggtcgggg cgctgaaggg ggtctcggac cgtgacggcg
     2221 agttacttca ggaggcgttc ggggtcaaga gcatcgcgga cctggccgag ttgaagtacg
     2281 tccgctgggc gcaggcgctc gccgctctcg acacggcaag gtaaccggcc cccgaactgc
     2341 cgtggtgcag tgcgcccgtc atgggtgcgc ggcaccgctc acacgaaaca cacgcacgat
     2401 aaggagtgga cgccacgatg gtgttcaaac gactgctcgg ctcgctcggc gtgggcggac
     2461 ccacgctcga cacggtcctc gaccccggtg cggccctgcc cggtggcgcg ctctccggcc
     2521 gggttcacct caagggcggc aacgccgact tcgacatcga gcacatcacg ctggagctcg
     2581 tggcccgggt cgaggccgag cacgaggagg gggagagcgc gggcgcggtc gtcttcgacc
     2641 ggttcaccgt cggtggcggt ttccggctcg ccgaggggga ggagcgcaac gtcccgttca
     2701 gcgtgacgct gccgtgggag accccggtca ccgagctgta cgggcaggga ctgggcatcg
     2761 tcctgggtgt gcggaccgag ttgtcggtgg cgggcgcgaa ggacaagggc gacctcgacc
     2821 agatggccgt gggtccgctg ccggtacagg aagcgatcct ggaggccctc ggacagctcg
     2881 gcttcggctt caagtccgcc gacctggagc tgggtcgcat cggcggcacc ggccagcagc
     2941 ttcccttcta ccaggagctc gaactcactc cgcccccgca gtacgcgcac caggtcaacg
     3001 agatcgaggt gaccttcctc gccaccccgg gcggaatgga ggtcgtcctg gaggcggaca
     3061 agcgcggcgg cctgttctcc tccggccacg acgcgctcac ccgtttcacc gtcggccacc
     3121 acgacgtgcg cgactggaac accgaagtcg acggctggat ccggcagctc gtcgagcacc
     3181 gcgcgtcgta cggctcccac gccgcgtacg gccacggcga cccgcacgcg agcggcggcc
     3241 acgacgacca ccaccaagac agccaccacc gctccgggcc gggcatggga accgtggtcg
     3301 ccgcgggtgc ggccgggctg gcggtcggtg tcgtcggagg catggtggca gccgaagtcg
     3361 tcgacgaggt gggggacttc ttcgagggcg acgaggaaga agagggctga gaggccgtgg
     3421 cgggccggaa gggttgatca ggcgctgacc gtgcgcagaa ggtgatcggc gtcttccggc
     3481 tcgcccggtc ggcccacctc cggccaggaa ccgtcacgca gcagatccgg agggcggggc
     3541 acccacgccg ccgccggccc gcctcgcctc ctgctcgtgg tgccggacga gggtgagcga
     3601 tgacatccgt ctgcgagagg gcgaacggcg tcgtctccgc cggcccggag ccggccggcg
     3661 gggaaccgag cgtggtgctg gtgccaggca cggacatgaa cgccgcggtg tgcatgggca
     3721 tggccgagtt gccggtggca cggtggcaca ccgtggtgaa ggcgcgtcct cacaggggcg
     3781 tcgccgcgtg caggatgagg accatcgtca ccgcggagtt cgcggacgac agcgcggaca
     3841 ccgcggtccc cgctgccgcc ccccaggcgg caaggcccac cgaggtgaac accgacggcc
     3901 agctgcgcat cgcgggcgcg gggccgagca gtgcggcgac ccggcgcggc accgggcccg
     3961 gcgcggcgaa gccccccagc gtgggcaccg gagtcccccg ggagaccagg gccgccttgc
     4021 cgatcgcgca cgccacggcc ctgcggctgc cgaccgcctg cgccgcgtcc tcgtccgccc
     4081 accgttccgc catgtacgcc acggcggtgc gcagggggcg caggaacggg ttggcacgtg
     4141 cggccagttg gacggcgagc aggaaccggt gatgccgggc tgcgagatgg gcgcgctcgt
     4201 gggcgaacag ggcgcgccgt tcggccggtt cgagacagga cagcagggcg gtggtcacca
     4261 ccacccggcc ccgtcgcccg ccggggaggg cgtacgcgta cggcacttcg tcgggcagta
     4321 cggccacctc cgtgccgggc aggccagcga gtgcccggtg ggctcggtgc aggacccgtc
     4381 cgtgccgcca cagcgtgcgg cagcaggtca gcagcaccgc gagcagcgcc gggatggcca
     4441 gtttcccagc cacctcgtcg tggggcaccg cctcgcgcac ctcggggtcc gaccaggcgt
     4501 cgggcagtgg attgccgggc agctgcgcgg tgccgaccac catcagcagc cccagacaca
     4561 cggtgctgca caccgccatc accacggcca ccgcggtcag gagccgggtg gcggtccgcg
     4621 ggtgcagccg ctgctcggcc aggcgcgcta tcggccacgc cgtcaacggc aggaccagcg
     4681 gcagaaagac gaacaccccc atgaggcttc agtcttccct ctcgtccttg gcccgaccca
     4741 gcagttcgcg cagcagccgc tcgtcgtccg gttccaggga ggtgacgaag ctggccagca
     4801 ccgcctcgcg gtcgctctcg gcgtcgagca ccttgcgcat cttgtgcgcg gccaggcccg
     4861 cctggtccga ggccggtgtc caggcgaagg agcggccggt gcgctcgcgg gccaccgcgc
     4921 ccttggccag cagccgggtc aggatcgtga ccaccgtggt gtaggcgaga tctccgccga
     4981 cgcgctcgtg cacccatccc gcgttgaccg ggctgtccgc ctcgcgcaac gcggacagga
     5041 cgagcgcctc cagttcaccc tgtccccgcc gcggaggacg ctgccgctga tccgtcacgc
     5101 cctgtctccc ttccgctgac cccgagttca gggccggtcc atcgtatcga cgccctaccg
     5161 gccgctcgcc gcgccgtgac cgctgctccg ccgccccgca ccgctgcatc tacgtgattg
     5221 tagaagccag gttgccggga cgggctcttc cgcgcggtgc cgacggtgac cgcgacggca
     5281 aggagagacg gtaggcaggg gcgtcatcgc acgggtggtg ctgggacttc tcgccggggc
     5341 cagggccagg gccgtcctgc cggggcgcga tccgcgcgga ctcatcggta cgacggccat
     5401 cggcatcgcg ggggcttcct gggcggccgg ctctccgcac agttcctcga ccggtcggtg
     5461 cggcgggagt tcctcgacaa ggccgacggc agcgcccccg caccttccag gacctgatgc
     5521 cgcccatcac acgccacctg tggaccgggg gcggaccgga acagatccag cggcacctgc
     5581 cgggcacggc aaccggtcac ggaccgagac ggcgacagcg acgtcggtcg ccacaacccc
     5641 cgaaacgctc ggccgtaccc ggcccgggcc aaacagaaga caggacccgc atgttcggac
     5701 ggagcgaaac cggccgtcat cctcatcgtc gtcatagccg ttctcgcggc gcggccgata
     5761 cgccggacaa caccagcagg ccatagacaa cagccgtggg ccgtgggccg tgggccgtgg
     5821 gccggcagcg ggctgttcgc gtcccacgcg ccggtgctcg ccgtctgggt gggcccggtt
     5881 tcgccaccgt acccacgccg agggcgaccg gcggctgcgg gaagtcggcg ccggcgagcg
     5941 ggagtcggcc cggctgcgcg cctcgatccg gctcgacctt gcgcgcgcgt ccgcccggag
     6001 gagacggccc tgtccgtcgc ggcggagatc tcgcgacctg gggtcggcgg cacgggtgtg
     6061 ccactgatcg gttcgggcgc accggtccac cgggggagag ggaagccgtg gtggcgcctg
     6121 agtacgtcgg acggggcgac tgagtatgtg gtcagatgcc cggcgccccg gcccggtgat
     6181 gtcctgtcgt catggacacg cacacctcgc gcccgcgccc cctccgccag gtcaccgcca
     6241 cggccggcgc caccggttcg gccctcgcgg tggcgctgct gccgctggtg gtcggggcat
     6301 tggtggcgcg ggcggccggt gccgacccga tggcgtcggt caacgccctg atcgcgggcg
     6361 gcggtgagcg ggcgaagctc tcccgtagtc atctgcccgt cctgcggggc atgggttcgg
     6421 cgccccgcag ggtgggcgcg cggctggcac ggacacgccc gccggagggt cgcccggcgg
     6481 gccgtctgcg ggggcggcgg ctactggccg gccgtgagga cgtacgtgtt gaggttcccg
     6541 accgtcgtga gcggtgacgg tgaacccagc tcgtagcggt ccacggcgag gtagttgggc
     6601 ttcttgcgcg cggcgggagt gcagaagttc tgcgcccggt tgcccagctt ggcgttgtcc
     6661 gtctccgcgg tgccgctgat cgtgtagtcg cggaagtggt tcatcacgaa cagcgggtgg
     6721 aaggcggcgg agtccgtggt gagcggtctg gccgtgcccc agcggctgta gcaggaccag
     6781 tcggagccgc cgagcccgcc gcccatggac cagtggttct cgacggtcca ctcccgctgg
     6841 tacatcacgc cgaacgtgtc acgggtgacg tagccggcgg aggtgtcgct cgcgcgggtg
     6901 cggtcgctga agatcagcag ctgcttgccc cgggccgcga ggtccgccat tctcggccag
     6961 ccgctcgtcg ccacaccctc ctggtccggc cggtacagca cgtcggacag gccgctcacg
     7021 gacgccagcg acgacttcag cacatcggag gcggtgtagt cctccaggaa gacggtcacg
     7081 aactgacccg ggttggcctt gaggaaggtg accatgtgct ggagatcggt ggcgagcggg
     7141 accgggttgc tcaccccgtc acagctgttg tggcagagca tcgcctgtcc ggacaccgtg
     7201 tacgcgtcca gcatgaaccc ccgcactccg tcggtgagtt gtcggctcac gccgcgcgcc
     7261 tggttcggga agaggctgac ggggaacgac gcgaagttgc cgtcgacgcc gttcgcgtaa
     7321 gcgttgtgcg aggtgaggaa cgagacctgg tcgagcgtgc gcgtgtcggc ggagggcatg
     7381 gccgacgtcg cgtaggagac cggtgtgagg tgccagcggg cgtaggcgcc gctcgacccg
     7441 agctgcacga gggaggggtc ggaggacgta cccgtcaggt actgcgaggt tcccggcaca
     7501 ccgatggtgt acgtgctgtt cgcggcctcg gtgaccgtcc acgtggtgcc gtccgcgccg
     7561 caggccgcgg tcaccgccga ggtgccgccg cgcccgaggc agatccccga ctggtcggcg
     7621 ctgcgcagct ggtggccacc ggtgaccgcg acgggcgtcc actgctggtg gtcctcgttg
     7681 cccttggggt tgtgcgcggc gaccgtaccg ccgttgtccg ccgcgttgag gccggtgacg
     7741 gagttctgca gatacaccga gtacgtgggg accgccgcgg cggcgggtcc cgagaacgcg
     7801 acgggcacac ccagggcgag cgaggcgacc gcgcagagcg cgcgggcgcg gacacgacgg
     7861 cgggaacggg gacggggacg gggacgggga cggatctgac tcacggggtt ccttccactc
     7921 cgggcgcacc gggatgatgt cagaggcatg acacaccgtg gaccgggtcg tgcaccagac
     7981 ccggcgcagg aagtcctcgt gagcgtgaac gcgccgttct gtggcgggac ttgagtcagc
     8041 cgcactccct ggttcgagat tcaagcagtc ttggggattc cgtggagaag atctgtttaa
     8101 attctgaaac ccgttcgaag agagaccacg cgtgagtgaa ccgacagcct ctgtctgccc
     8161 gcagtgcgga accccccggg cgacggacgg caccccggcc tgctcctgcg gccgcctcgc
     8221 gtcggaggct catcgggacg ttcgcgcggc acaggccgag gccgcggagg acttcgaccc
     8281 ggtgcgcata cgcccgttcg tacaggtggg cgacgacggc gagccgcagg ccacaccgcc
     8341 gacgggcgag gtgccgccca cggccggtga cgacgggcag gccccgaccg acgcgcagcc
     8401 cccgaccgag gcgaggatcc cgaccgacgc gcaggctccg gtcgacgcgc aggccgtggg
     8461 cgaggatcgg gccatgcccg atgaacggga cgcgggcggc gcgcacaccg ggggcgacgc
     8521 accgcgctcg gacgggcggg acgcgggcgg taagcggcgg cgcagggtgg cgctggccgc
     8581 aggggtgggg gccgccgcgg ccgccgtcct ggtgacggcc gggatcatcg gtggcctctt
     8641 ctcgtacgag gctccctcgc gggacggctc gggtcccgac gacatcaggg cgggccttcc
     8701 ggaggcggcg gaaggccagg aggcgtcgcg gtcggcgacc ccgtccccca cgggctccac
     8761 ggcgtccccg tccggcagcg cgaccacctc gccggcggcg accccgacgg aaaccggggc
     8821 cacccccgcc ccgtcgacca gcatgaccaa ggtcccctcc ggcagcgacg ccaccgtgac
     8881 ggcggccccc gcgccgcccg tcaccgacgg gccgccgccc gtcctcggtc tcggggacca
     8941 gggcgcggag gtcaccgaac tccagctgcg tctgcgccag atcggcttct acaacggcga
     9001 ccccgacggc gactacgacc gtgaggtcca gagcgcggtc cgcggctacc agctgacccg
     9061 tgtcctcctg gaggacgagt cgggcgtgta cggcgaggcc acccgcgccg ccctcgaatc
     9121 cgagacctcg gaaccgtgac cccacccgga caggcccgtg tacccccgtc cctcacgcgg
     9181 ccgcggcggc gaggtgccga cgggcctggc ccgccgtgtc gctgtggggg aactgttcgg
     9241 cgatctgctg ccacatgtcg cgggcccggt cgacgccctc ggggtcgtcg cgcgcttcga
     9301 gggccagggc gaggtgggcc cactgccggg catggccgcc ggagtgctcg acggcgtcct
     9361 ggaggaggtc gacggactcc tccagacgcc cctgccggta ggcgacccag ccgcaggcgt
     9421 cctcgcacag ggccgaccgg ccgggctccc acacctgtca cgcactcttc ggggcaccct
     9481 ccgccggcag ccgcgcctcg tccagacgga tgccctgctc cgcgtagaac atcgcgagcc
     9541 gcgcggtgag cgtgaccagc gcggcccgcg acgggggttc ctcgtccgtg ccgtggaacg
     9601 cctccagccg ggcgtcgatg acgcggtcgg cgggggagag cggtcagagg tggccggccg
     9661 gcggttcggc ctgggcctgt tcgagtcggt gcagttcggc ggtgacgcgc gcgcggcggc
     9721 gcgccggctc ggggtcgtcg tcgaggacgg accagtccgc ctcgccgatg ccgtggtgat
     9781 ggtggtagag gtcgtcgatc tcgccgagtt cgaggtggac cgggttctcc tcggcgttcc
     9841 agtggtccgc gacccggttc tggtacacgg accgggccgg gcagggttcc gtggaccggg
     9901 gcggctgtgg ggcggtggtc gtggtgccgg ggtcgatgac ggtcaacggg cggctcctcc
     9961 ggtggtgtcg ggcgtcggcc ggccgtgcgg ggcgccggcg ctaccagtag tcgggcaggc
    10021 tgtagcggtc ggtgtgggtg gcgtgccact cgtgattgcc ggccacccag gcggcgagac
    10081 cggtggcgta gcgctcgatc ggcggggagg tcgcggacag ggccgcggac tcctcctcga
    10141 acgcctccat gatccggttg tggatctcga cggcccgcag ataggcggcc ttcagtccgc
    10201 accgctcgtt ggcggcgatg acgacgggca gattgaggtg gcccgggtcg ttcgacagct
    10261 ccttggtgaa ggagtacagg tcgttgacga tcgtggccgc gttcccggcg agcgcggtga
    10321 tccgttggac ctcggggcgg gcgtagaggt gctccggcag ctcccagccg tccacggcgt
    10381 cgaccaccga cagacagggc cggaagttgt tgaactgccg catcaccagg tactcccaga
    10441 cctgcggcat gtggtccgtc tcggcccagg ccgcttcgcc gaggtagccc agatgcagcc
    10501 gggcgaggtc gtgcacgagc cggtcggtct ggctgggtgt ggcgagggcg gcgtagtcgc
    10561 ccagcgcgaa gtggtacgac cgcagcggac cgtcggcccg tacaccccgg cgccacccct
    10621 cctccgtccc cggcgtggtg tgcagcgggt cgagcgccga ctgggccatc agcagccggc
    10681 cgccgaggcc gcgcggggag ccgcccttgc cctcgtcgac ctcgcagtag acgttgtcga
    10741 ccaggtgctc ggcgagcagc agcttcccgg cggccgtgag gtgttcgagg ccggccccgc
    10801 ccggatgcgc cagcacgatc gcccggccca ggccgaagcg tgcgaactgc ccccgccacg
    10861 tgctggggaa cagatcgagg cgctccgccc aggactccag ccgacggtcc acctccgccg
    10921 cccgtgccgg atcggcgggc acggcgggcc ggtggcgcag cccgggaacc gcgcccgacc
    10981 gccgagcccg tctcgcccgc gcgggactcg gcggccccgg cagccgcgta cgcgcccgac
    11041 tcgactgcac cggcggccgc gcacgggcgg aactcggcgt ctccggcggc caggtggggg
    11101 cggacccagg cggctccggc ggcctgtcgc gggagggcgc cccggccact gacggctcgt
    11161 tcattccggc atccacccca cctgcacgtt ctccaggatc ccggccgcgt cgggcaccaa
    11221 gacggccatc gagtagtagg cggtgaccag atagctcatg atcgcggtgg cgtcgacgcc
    11281 catgaaccgc acgttcagcg agggttcgta ctcctcgggg atacccgtct ggtgcagccc
    11341 gacgaccccc tggtccttct cgcccgtgcg cagcgcgatg atgctcgtgg tgtgctgcgg
    11401 ggtgatcggg atcttgctgc acggcaggag cggcaccccg cgccacgccg gcatctcgtg
    11461 tccttcgacg ttcacggtgc cgggcaccag accacgccgg ttgcactgcc ggaagaacgc
    11521 cgcgatcgcc ttcgggtggg ccaggcagag gcgggtcctg cggcgcatcg acaggagttc
    11581 gtccatgtcg tccggggtcg gcggcccgga gaaggtgctg atgcgctggc cgtagtcgat
    11641 gttgtgcagc agcccgaagt cgcggttgtt gaccagttcc cactcctggc gttcccggat
    11701 ctcctcgatg gtcaggcgga gttgctgctc cgtctggtcc atcgggttgt tgtagaggtc
    11761 cgcgaccctg gtgtggaccc gcaacacggt ctgggtgagg gagagttcgt actcgcgggg
    11821 cgcgaggtcg tagtcaacga agccgcccgg cagcgtcaac tcgcccacat gtccggcctc
    11881 cagggggaca tcggcctcgc ccttgcggtt catgggcctg cgctgctgct cggcgaaggc
    11941 gtcgaactgg gcggcgaggg agggcgtccg ctccacgaac gccatcagca cgtcccagtt
    12001 gagcgccagc accaccccgg ccgtgtcggc ccgtaccgag ctgagccaca gcgggtcggc
    12061 gtgtccgatg gcctcgtcgc ccagcccgtc gccgtcgctg atgacgccga ggacctcctc
    12121 ctcgccgtac ttgccggtgg tgtaccgggt gaacctgccg tgcaccacga gatacgcctc
    12181 ggtcaccggc tgcccggcgt ccaccagcac ctggccggca cgcacctccc gcacccggaa
    12241 ccgggcggag atctccctga gggccgggag gtcggcgtaa ccgcgcagcg ccggaagctc
    12301 ggtcagggtc tccgggatga ccttgacgtc gtcggcgccg ttctggtcga actgcacccg
    12361 gccccggccg atccgcagct gcagacggcg gttgacccga aaggtgccgc ccttgacgtc
    12421 cacccacggc agcgtcctga gcagccatcg cgaggtgatc gcctgcatct gcggttcgga
    12481 cttggtggtc gtcgcgagct gccgcgcggc gcgggtgctg agactggtga agtgctgctc
    12541 gtcggcgggc tccggtgcgc tttcggagga gcttacgggg gcggtcacat tccctcccga
    12601 gaggtgagcg gatgtgcgtg gacggacggg gcgcgcctgg acaggggcgg atcgccggat
    12661 gctgccggga cacgggactc gggtggcgcg cgtacgacgt ggccgtgggc ggattccgag
    12721 gcgagggacg ccggcggggc ggcgaggtga ggcggcacac gcggatgggc ggcatgtgtc
    12781 gcaggtcaag ccaaacagcc ggacggccgg tcgggcaccg cgtgaaaggg gcgacttcgc
    12841 gtcctgggga tgcggaaacc gccgactgag gcagaacgcc ggcggggcgg tgctcccgcg
    12901 ccctccgccc gcctcccacg accggcgcgg agggcgtacg acgccggtgg tgcgcagggc
    12961 gtacgacggg gacggcgagg agggcccgac ccctgccgta cgacgagggg ccgcccggag
    13021 gcggcccctg atcagcggcg gttcaccggc ctcgccgtgg cggcccgttc accagcgcgg
    13081 cagtcgcagc tcgtaccccg gctggatccg gcgcatgtac ccggtgtcgt cacgggagca
    13141 catccccgag tcgacgtaca gccggtgcag ccggtcgagg gcgtcgtggt ccagctccac
    13201 gcccagcccc ggccccgtcg gcaccgctac ctccccgttc cggaactcca gcacgcccgg
    13261 cacgatcacg tcgtccgccg aattccacgg gtagtgcgtg tcgcaggagt ggtcgaggtt
    13321 ggggatggcg gccgcgacat gggtcatcgc ggccaggctg atgccgaggt gcgagttgga
    13381 gtgcatggac agtgcgagcc cgaacgcctc gcagacggcg gccagttcgc gggtgcggcg
    13441 cagcccgccc cagtagtggt ggtcggtgag caggacctgc acggcgtcct gctcgacggc
    13501 cggcctcaga tgctcccagg ccaccacgca catattggtc gcgagcggca tcggcgactc
    13561 ctcggccacc tccgccatgc cggggatgcc ggcggtcggg tcctccaggt actccagcac
    13621 gccgtccagt cggcgggcga cgtacttcga ggtctccacc gtccaggccg tgttgggatc
    13681 gagacgcagg ggctgtccgg ggaaggcctc cgcgagcgcc tcgacggcgg cgatctcctc
    13741 gtccggcggg aagacccctc ccttcagctt gaacgaccgg aagccgtacc gctgttgcat
    13801 cagccgggcc tgttcgacga ccccggccgg gtcgagggcc tcgccccagt cgtccccgac
    13861 cgccgggcgg ccgtcgaggg cggggtgttc ggcccacttg tagaagaggt acgcggcgaa
    13921 gggcacggtg tcgcggaccc ggccgccgag cagatcgctg accgggcggc cgagcagtct
    13981 gccctgcgcg tcgaggcagg cgacctcgac cgccgaggtg gtccagccgc gctcgtggga
    14041 gccgggcacg gtgggccgca gcgcggtgtc gatcgcggcc gtcacggcgg tcgtgtcgaa
    14101 gacgtccagg ccgaccaccg ccttcgcggc gatgtcgagc cgctccaggc ggacggtgcc
    14161 gcccgtcgac tcgccgagcc ccaccgtgcc gtcctccagg acgagttgga ggacggtccg
    14221 cagcgcgagg ggctcgtgga cgccgcctga gttgagcagc ggcgggtcac ggaaggcgat
    14281 cggggtgacg atcagctcgc ggatccggga gcccggtgtg ccggtcatac gcccaccccg
    14341 tccgcgcggt gacggtgcgg gccgcgacgg ttcgtcctca cgcgcccacc acctccaggc
    14401 cgtggtcgat cagcttcgcc agccgggcca cgtgctccgg cgtcggatcg accaacggcg
    14461 cccgtacccc gccgacgtcc aggccgcgca gggtcacccc ggccttgacc agtgccacgg
    14521 cgtaaccggg cacctcgtcg cgcagttcca cgagagggcc gtagaactcg tcgaggagcg
    14581 tggcgaccag cgtctcgtcg tgctcggcta gtgccgcggc aggcaacctt tgcccgtcaa
    14641 ggagcggcgt ccggtgcgtg ctctcggcgt gccgggcgaa cgtcctcgta ctggatgtac
    14701 ttgggcttgt gcccggtgcg gcgagagtgc gtgccgggcg ttgcgacggg gcaaacgttg
    14761 cctgtcgcgg cactagggcc cggtggaagg cgacggcgat ctccggggcg aaggcgaaca
    14821 cggcggagga gtgcaggccg acgccgatgc cctggtaggc gggcgcgatc atctcggcgg
    14881 tgggcagccc gttgaagaac tggaagccct ccgtgcccgg cacggcccgt accgcgcgga
    14941 cgacgcggtg catccgttcg atgtcaccga tgccgtcctt gaggccgacg acgcccggca
    15001 gcgcggcgat cgcggcggcg gtgtccgggg tgaggcgggc ggtgccgcgc tggtagaaga
    15061 cgaccggcag ggcggtggcc tccgtgacct ccttcacgta acggatcagg ccctgctgcg
    15121 gcgcgctcac caggtacggc ggcagcagca ggatgccgtc ggcgccggcg cgttcgacgc
    15181 gggcggcctg gtcgcgggcg accggaggag ggcccccggc ggcggccagc acggggaccc
    15241 gcccggccgt cgtcgccacc gcgatgcggg tggcccgttc gatctcctcg gacgtcagcg
    15301 cgtggaactc gccggtgccg caggcgacga acacgccgcc ggccccggcc gcgaccccgg
    15361 cctcgatgtg ctgtgcgagc cgttcctcgt ccagcgaacc gtccggagcg aacggcgtga
    15421 ccggaaagaa cagcactcct tggaacttca tgtcttcctc aaacgtgggg gtcgggtcag
    15481 cccttggtgg cgccggcggc gatgccggtg accagcgagc gctggaggag cagatggacg
    15541 accggatccg caggtcgcgg ccccgaacgc gagccccgcg acggtgatca cggcggccag
    15601 gcggcgactt cgtcggcgaa cgcccatggg cacactccgt cgttcttccg ggccgtccgc
    15661 ccggctgttc atattcatga acagccttca cgaatctaaa tgatcggcca agctacggag
    15721 cgtttcgttt gcatgtcaag acatgggtag gagatttcac cggggtcaca ccccgcctct
    15781 gcgggatcct gtggagcgac cggggagaag gaaacgggag gtggtggccg tgggtgagcg
    15841 cacggcaccg agtgccctgg cggcccggtt caccggacgg ccgacgaccg gtgaacgccg
    15901 gttgtccggc acgctcaccg aggtcaccct cgacgacggc cggaaggtgc tggtcaaggt
    15961 gggcgatggt cccggcgcgg cccgggccga ggcggccgga ctgcgctggc tcgcggaggc
    16021 ggacacggtc cgcgtcccga cggtccacgg ccaccacggg aaccgcctgg tgatcgacct
    16081 ggtggaccaa ggggcaccga gtgccggggc tgcggcccgc ctcggcgccg aactggcagc
    16141 cctgcacggc gccggcgcgc ccgccttcgg cgccccgccg cccggcggcc ccagggaggc
    16201 gtacatcgga cgcgccccca tgcggaacgt ccccgtcccc ggcggcgact ggcccgcctg
    16261 gtacgccgag caccgcgtgc tgccgtatct gcgccgcgcg gtcgacgacc gcacgatccg
    16321 ccccgccgag gccaccctga tcgaggaggt ctgcgcccgg ctgcccgacc tggccggccc
    16381 cgccgagccg cccgcccggc tgcacggcga cctgtggaac ggcaacgtcc tgtggggcgc
    16441 cgacggccgc gcccgactca tcgacccggc cgcgcacggc ggccaccgcg agaccgacct
    16501 ggcgatgctg gcgctgttcg gctgccccca cctgggccac gtcctggacg gctaccagcg
    16561 ggccgccccc ctcgccgacg gctggcagga ccgcgtcggc ctccaccagc tcttcccgct
    16621 gttggtgcac acggtgctgt tcggacgggg ctatgcggag caggccctcg cggtggcgag
    16681 ggcggccctc gggaagtgag tcaccggcgg tccgccgcat cgtgcgggcc gcacatacga
    16741 caccgggagg cgccgcgcgg gcgcctcccg gtggaagcgg agggcgagga gagcgaagga
    16801 actcggtttc atgtggagtg aatgagaagg aagccccttc atggcctcgc cacgggccac
    16861 gctagcactc agcccgggac caggtcgcgc agattttcga gggtgatgat ccgggagtcc
    16921 gggtgcagcc cctcgggccg ttcgagaccg atgtacgtca cgggctcgtc cggcacccac
    16981 gtgccgtccc acaggtccat gaccgttccc tcacgggtca tcaggtcgat caggtacccc
    17041 accgtcagct gctcgcgctc cacgacggca cgcaccacct tggacaccga tgcctggttc
    17101 tcctcgaccc ggttggccga cgagatgccc ttcagataca ggtgcagcca cttcgcccgc
    17161 caccggccgt cctccccgcg ccggaacgcc agcggcagcg ccacccggcc caccccgcgc
    17221 agctccgact tcatgcgcac cgtgcgcggc tcgaacggcc ggcccttctg cgcgccgtcg
    17281 cgcaccatga acccgaagaa cgactcctcg acctcctcga agccctcgcc cgcgtagatg
    17341 ttgacctgcg gcacgatgaa cgtgccgcgc acccggtcca ggctcagctc gatgaactcc
    17401 gaggcgccgt cgggcgcctc ggtgacatcg cccgagtgcc ggcccccgac ggccgtcagg
    17461 gacgtgtagg agagccagga gtcggtgctg tagtcgctgt gcaggagcag cgccgacagg
    17521 tcgtagtcgg tgcggtgctc ggtctccttc cagtacacga agaagcgcag ccgctcgccg
    17581 tcgacctccg agaccgaacc gcgcggcagc accccgagcc cggccgccgt cgcccggccg
    17641 ctgagcggca gtgccacgtc caggacgtcc gggtcgacca gcagccgccc cggctccggg
    17701 agccggcgcc ctatttcggt gtcgagggcg gcgatcaggc gatcgcgctc ggcggcggga
    17761 acaggtggcc ggtcgtcggg ggagacccag gcgcggcccc ggcggttgac gaagacccgg
    17821 ggtgcgtcgg tctcccgctc ccggttgtgg aggtgctcgc ggaccgacag gacgacccgg
    17881 ccggagacct cgggggcgac ctccaccgcg gcggccagca ccgcgtcccg ctccgcctgg
    17941 tcggcggcga tccgcagcag gaggtccagg gtgcggaaca gcctgccggg agcggccttc
    18001 agcagcccgg ccgccccggt gacgtcgaac tcgtcgagca gtttctcgac ccggctgtcg
    18061 aaggaccgcg cctccttctc gccccgcgcg acggcgaaca cgtcggcggc gtgcggccag
    18121 cgcgggtact cgtgcgggtg gaggcgctcg ccgagccgct tgaagggctc ccggtgcgcg
    18181 tgcacatcgg ccagcttcgc cgggttcgcc gcgaccacgg cgtcgaggcc cgcgagcagc
    18241 gcccggcgca ccggacgcga cagtgaccgg aaccgggtcg gctcctggag cgtcacgtcg
    18301 ccgcccgaca gcgcgcaggc cagccgcagc acatcggtga ccgtgtcgag gagcaggtcc
    18361 gccccggcgg tgagccgtgc ctcgttgacg acggcccggt tctcccgcac cgggatccgc
    18421 tccggctggg ggccgagcgc gcaccgctcg gcgaggaccc cgaggtcgcg caggtcgtcc
    18481 tcgcccagcg gggtcgtgct gcccgccagg gccaggtaca ggtcggtgag ttcgtggtcc
    18541 aggtcccggc ccgggtgcag cacggtgatc cggtcgccgg ccgaggcgat cagctcgtcc
    18601 tgcgccgcga gcatctcctc gtaggtgtgc tggtaccggc cgtacgtggg gaggctgagc
    18661 aggtccagca ccccgttcgc cagctgggtc agcacgccct cgcgcgcctt ctcgtcgccg
    18721 agagcccgcg ccacgcaccg cgtccagaac tcctcggtgc ccgggacgtt cgcggggaag
    18781 tcgatgaagt aggagttgtg ccggacgtgg tcgccgacca tctcgcgcac ggtgcgcagg
    18841 gtccgccggg cggtgtgcag gacggcggcc tcggacagcc cggacagcct ctgcagcagc
    18901 tcggccgaga gcttgaagcc cacgtccatg agcgcggcgt cgaactgccg cgcggcggcg
    18961 gtgccgtcac cggcggaccc cttcgggacg gggaggcggt gggtgtgccg gacgaccagc
    19021 gattcgagac tctgcgccat tccgggatga tcgcagaggt gtacgaatcg gcgcaccgga
    19081 gttttcccac gccgccgggc ccgaccgcgt cccgccacct ccgtacatgt gcgtccggcc
    19141 tgcgtcgcgc atgcgcgcgg aaaccgtcga gggccggggg cgagggccgg gggcgagggc
    19201 cgggtccgag cgaccgtcgc ccaccgcgtc cagtgcctga accaggcgcg gggtcgccga
    19261 cttgtcggtg cgccctgcgg ggcgccggtc cgggccctcg gccgtcagga ctcggagtcg
    19321 cgcaggtcct cgacccgctt gagtacagct ccacgtgtcg tacgcgtgcc gcaacgtggc
    19381 ccgcggccgg ctcagttgga gtgtccgcag gtgttccggg gtgaggcgtt cgccggtgtc
    19441 cagcaggtca cgggggaggg gctcgccccg ggtgctcatc gcgactcctt cgcgctcacc
    19501 gtccgatgcg ccgcccgatc attcggttac tgtacgtcac ggtcgtgtga cccatccgtg
    19561 gccgcgcctg tcgagaagcc caaggggccg ccgggggcgt gaagcggcgt acgggtcttg
    19621 cccggcggct cgaatcgcgt cacactggta ccgaacgaat ggtcggttgg gaagctggta
    19681 tcgatgacga cgacagactc cgccggggcg ccgtcccagg acgccgagga cgccctccag
    19741 cagcacttcg acgcgacgat cgcgcgggac cagcggatcg agccccgcga ctggatgccc
    19801 gacggctatc gcagaacgct cgtccggcag atcgcgcagc acgcgcactc ggagatcatc
    19861 ggcatgcagc cggagggcga gtggatcacg cgcgcgccct cgctgcgccg caaggcgatc
    19921 ctcttcgcca aggtgcagga cgaggccggc cacgggctct acctgtactc ggcggccgag
    19981 accctcggcg ccgaccgcgc ggacctgacc cgccggctga tcgagggccg ccagaagtac
    20041 tcgtcgatct tcaactaccc gaccgcgagc ttcgccgacg tcggtgtcat cggctggttc
    20101 gtggacggcg cggcgatctg caaccaggta ccgctgtgcc ggagttccta cggaccgtac
    20161 gcgcgcgcga tggtgcgcat ctgcaaggag gagtccttcc accagcggca gggctacgag
    20221 ctgctgatga cgatgatgcg cggcaccgac gcgcagcggg cgatggtcca ggacgcggtg
    20281 aaccgctggt ggtggccctc cctgatgatg ttcggcccgc ccgacgacgc ctcgcccaac
    20341 tcggcgcagt cgatggcctg gaagatcaaa cggcacagca acgacgaact gcgccggcgc
    20401 ttcgtcgaca tgaccgtccc acaggccgag aagctcggcg tcaccctccc cgacccggag
    20461 ctgcggtgga acgaggagcg cggccgccac gacttcggca cccccgactg ggacgagctg
    20521 aagcgcgtga tctccggcga cggaccgtgc aacgaccggc ggatggaacg gcggcggacc
    20581 gcccacgagg acggcgcctg ggtgcgcgag gcggccaccg cccacgcggc caagcgcgac
    20641 gagcgagccc ggaaggggac ggcggcatga ccggcacgaa caagggcgac tggccgctgt
    20701 acgaggtctt cgtacgcggc aagcgaggtc tgaaccacgt ccatgtgggc tcgctgcacg
    20761 cagccgacga ccagatggcc ctcacccacg cccgcgacct ctacacccgc cgcaacgagg
    20821 gcgtctccct ctgggtcgtg cgctccgagc acatcgccgc ctccacccgc gacgagaagg
    20881 accccttctt cgagcccagt gccgacaagg tgtaccgcca ccccacgttc tacgacatcc
    20941 ccgacgacgt cccgcacatc tgaggagcag ggaatgagtg acgaccacgt ctacctgacc
    21001 ctcgccgagg gacacgagga cgacgcccgc tgggcatacg gcaccggctt cgaggacccc
    21061 ctgcacggtg tggacaccac ggttcccgag ggcgtggacg ccgccgaact ggccgccgac
    21121 tgcgtggcgt tggccgacga cgccctggtc tcggcccagc ggct
//
