LOCUS       NZ_CP080647            25355 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces akebiae strain MG28 chromosome, complete genome.
ACCESSION   NZ_CP080647
VERSION     NZ_CP080647.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces akebiae
  ORGANISM  Streptomyces akebiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10257202)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2021) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019599145.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:26:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,127
            CDSs (total)                      :: 9,036
            Genes (coding)                    :: 8,727
            CDSs (with protein)               :: 8,727
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 142 of 309
            Pseudo Genes (incomplete)         :: 231 of 309
            Pseudo Genes (internal stop)      :: 20 of 309
            Pseudo Genes (multiple problems)  :: 77 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5279132
            Orig. end                         :: 5304487
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP080647.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25355
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="19"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25355
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25355
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15355](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15355)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    589..603
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    660..673
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            1954..3927
                     /locus_tag="K1J60_RS22685"
                     /old_locus_tag="K1J60_22685"
     CDS             1954..3927
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659768.1"
                     /locus_tag="K1J60_RS22685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22685"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_259407862.1"
                     /transl_table=11
                     /translation="MAVVITVPICLLLTVAGLAVHGRAEALGDARTTRAEVGLSLRIQA
                     LVHQLQRERGLTNGLLGGEKEFRPPLSATRKRVDTALRGMRTESAVEDVVQRHLRRLAD
                     IRSAADRGTAGQAATLTFYTSAVNALNAVDPVAETATGADRQLRDGLAALRELAAAKES
                     VALERGLLNGVFAQGAFQGREYIDFTEVRATRVAALTRFRQVATAPQRAALEKAFATED
                     AERATAYEKQTEGAADGSPLRADARTWWEAMTVLVDDLYAVQQSVGDDVRDRADRLSHD
                     AELALAAYLVTGTLIAALVAGLAAVASRSLTRPLRGLAETAHDVARRRLPAAVARIQQS
                     PQDSAQLLTPEDAQDTPDARLLGGAAEIAEVAASLQQVEHTALQLAAQQAGLRRNTTES
                     LANLGRRNQSLVRRQLGLITRLERQELDPDALAELFELDHLATRMRRNAESLLVLAGQN
                     PPRPTAAPADGLEVVQSAVAEVEQYRRVLIATVEPVRVRGHAVADVAHLLAELIENGLN
                     FSPPTEPVEVHGWYDTEDDTYSFGVVDHGIGMSEADKARAGALLSDSGEEALVAAPTRF
                     LGHLVVGRLAHRLGEGAQVHLFDTPGGGLSALLALPGRLLAPVEDPSTSPPPARPAVSS
                     LLNGFRAGVARAEARNPQGASS"
     gene            3924..4334
                     /locus_tag="K1J60_RS22690"
                     /old_locus_tag="K1J60_22690"
     CDS             3924..4334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382238.1"
                     /locus_tag="K1J60_RS22690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22690"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_189781019.1"
                     /transl_table=11
                     /translation="MTTAVQSFGWLVSEFVRTADGVTDAVAVSSDGLLMAASDSLGRDR
                     ADHLAAVVSGITSLAQNAATAHGFHGMKLVMIEMLGGFLMVGRIRDGSCLGVLAAEGCD
                     VGLVGYEMAVLADRAGELLTPQLVRELHSAPR"
     gene            4561..4997
                     /locus_tag="K1J60_RS22695"
                     /old_locus_tag="K1J60_22695"
                     /pseudo=""
     CDS             4561..4997
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999949.1"
                     /locus_tag="K1J60_RS22695"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22695"
                     /product="DNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGDIETVVLDSEGRSAWVARTGRFWRCSRCSRCSTTWERTLSSA
                     PTPWWR"
     misc_feature    complement(4598..4612)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            complement(5251..5655)
                     /locus_tag="K1J60_RS22700"
                     /old_locus_tag="K1J60_22700"
     CDS             complement(5251..5655)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS22700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_22700"
                     /product="hypothetical protein"
                     /protein_id="WP_220647792.1"
                     /transl_table=11
                     /translation="MNKRLIGMATVGTLAVAATLALTAGPAAAADCSVGQKGSRYACVQ
                     VNNKATDVKSIRVDNGNCVKVNYATRTANGGTRPADTKLQVAVRAYDSVEDRPLLYTYS
                     DTNCKYRNAKTVGWAGDSDSSNYRMVTIQP"
     gene            complement(<5802..>5928)
                     /locus_tag="K1J60_RS47195"
                     /old_locus_tag="K1J60_22705"
                     /pseudo=""
     CDS             complement(<5802..5928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611639.1"
                     /locus_tag="K1J60_RS47195"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="K1J60_22705"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTGFGIGLSTVQPVRE"
     misc_feature    5906..5921
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            complement(5984..6343)
                     /locus_tag="K1J60_RS22710"
                     /old_locus_tag="K1J60_22710"
     CDS             complement(5984..6343)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS22710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_22710"
                     /product="hypothetical protein"
                     /protein_id="WP_220647793.1"
                     /transl_table=11
                     /translation="MGAVLAAASIVGMAFAAPATAAQAPSNGWPVALTRVPAGVNSVLL
                     WSAYNSRYGCVQVTPGVDRTTNVRVSPTVNSNPVTLRGMLYSGRNCDGTWVGNAPEQGT
                     VPTDQQWTNYWFRLS"
     misc_feature    complement(6542..6555)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.74"
                     /tool="antismash"
     gene            <6676..>7672
                     /locus_tag="K1J60_RS22715"
                     /old_locus_tag="K1J60_22715"
                     /pseudo=""
     CDS             6676..>7672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075272.1"
                     /locus_tag="K1J60_RS22715"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="K1J60_22715"
                     /product="tyrosine-type recombinase/integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAAERTTKAEVTKAVREMERARDDENLGKPGQGWTARAWLEHWVE
                     NIAKPYVSENTYDGDEVDVRVHFVPGLGAHKLDTLEPEHLECFHRRTQTKAPRLEEEHI
                     EPYTIEEVQSLLVEAAKLRDSARWVVALALGLRQGEALGLHWEDVDLAAGYVRIRKNRR
                     RPKYAHGCGADPCGRKAGYCPRRSRRAASTSPPSPVRPAHHRSARSADQDSPPAPGSPG
                     AGTDQGRCGLGEQGIRLRLAGWRAPESPHRLPRLEAAASGRGRTGRPSS"
     gene            8497..10029
                     /locus_tag="K1J60_RS22720"
                     /old_locus_tag="K1J60_22720"
     CDS             8497..10029
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS22720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_22720"
                     /product="hypothetical protein"
                     /protein_id="WP_220647794.1"
                     /transl_table=11
                     /translation="MAASEKPEKSHQLPESVREHLVAIVFDTNSFPSGGLDLHVLKEWA
                     RRAELADLEVWLPEPVLWELAEHAAAAWEEQRASVRRAQKSMRRAGLEVPSEAPYNSRE
                     TVMATVESVVTTLNPAVRILTIDPDIAREALKDQILLRQPAKKKQDVKTGAADSAWLRQ
                     VLKEAGRNVDRFIVVGSDKDVEQAFKAWGLQKPHMVKLEHLDAALFVLDEFPEEEMASS
                     IVAFLQVHIDAPESGEGRDAALVLGEITNGDEVVGEWEYDQVQDVSVGRIHHVAGLSDL
                     TINRLTGIVKAQVFFSVELEYTGMRIDENGETVTHSETFPHAMVRDVLAFTIDDDGMVT
                     EARSETGQAHAFSGNSAFSDSWDAFAALLEAMSLIPGVDREELDGAEIGCELTWQVGGW
                     ELTFTSEEGHGDPHWSASATLSKDSMSHSAEFRCEWDGSLAPYEMPDLLPAYVIAAEDE
                     ESYLNSGEWTAPAWVLSKIWPSPHRREQMGISQSSFFDSVRELSNKEPDAQF"
     gene            complement(10001..11140)
                     /locus_tag="K1J60_RS22725"
                     /old_locus_tag="K1J60_22725"
     CDS             complement(10001..11140)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="K1J60_RS22725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22725"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_259407863.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.1e-26, bitscore:
                     90.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDSSTIEQAILAVLTGTPLTEAAERAQTSPEHLAEATERYRD
                     AGRSALDPQLGSWHQVNIEFTDYPTAERTFRTYLLPALRTGPIGAWWFVRKHPCWRLRV
                     QPGPGTRMEDAVAHLTEVLDNALSLGVAKRCWPFLYEPETIAFGGPHGMALAHTLFHTD
                     SVGILDYHQHVTDSTSGLPGPKETSLLATTLLLRAAGLEWGEQGDVWGQVEALRPLPTD
                     IDPDQVSSMVAPVRRLLTLDVGPALTDGPLAPLGNWVTGLEHCGQALADAARAGNLQLG
                     SRGILARHILFHWNRMGFTTRQQAIYSRAARETILGGREHEEHRGRPPPQPPRPSPPPR
                     TTRPRMITNRTSRDYAEALRRSPAARGRSGFRTAHPALC"
     misc_feature    complement(10892..10894)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11163..12311)
                     /locus_tag="K1J60_RS22730"
                     /old_locus_tag="K1J60_22730"
     CDS             complement(11163..12311)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326102.1"
                     /locus_tag="K1J60_RS22730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22730"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_220647795.1"
                     /sec_met_domain="LANC_like (E-value: 4.3e-44, bitscore:
                     149.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPPALDTDATLRQSLARGSLGIALLHVERARQGTGSWKTAHQ
                     QLADIGPLLDGNETGLFLGAPAMTYVLHWTTVDNIRYTGALQTLDRIVATHIRHRLAAA
                     HARIDCGEPTTFAEYDLLRGLTGLGALLLRRAPEGDELKGVLEYLVRLTEPLHTANGRP
                     RLGWWVSHSPVNLSARTPDGHANAGLAHGITGPLALLALAKLRGITVPGHEKAMLRICS
                     WLDQIRVSDHRGTRWPRWITNTTTVPPHLAAPSWCYGTPGLARAQQLAALALNDPDRKR
                     MAERALLYCLADPTQLDQLTSRGLCHGLGGLLRVLQRVTHDADEPRAFVHHLPQLSERF
                     LTTESPAETGFLNGSVGATLAFQNIQEGTLPTSDWDACLLLI"
     gene            complement(12308..15355)
                     /locus_tag="K1J60_RS22735"
                     /old_locus_tag="K1J60_22735"
     CDS             complement(12308..15355)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="K1J60_RS22735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22735"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_259407864.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-183,
                     bitscore: 608.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.7e-20,
                     bitscore: 71.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-32, bitscore:
                     112.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHAIDASMIRASVFPLAATLPPWPDLDGETPADVERWRDWIAQV
                     WADDTRAAAIEFAAPLLASAIRDVLDGERQRPRSVRRTAASLARYLLRMQHRATPFGLF
                     AGPALVSIGGTARVKWGKGHRAFARADADWLNAAITALEGNREVLRRLPVVVDPTCTVR
                     GTRVAVPHQSGTNGPTDTTLRRTQAVEAVLTLARTPITVGDLVTKLLGDYPDTPTAVIE
                     NMVSSLVAHRVLLTSLHSPMTCDDALGHLIARLDATGATATSDKAETAEELRKIHQLLT
                     LHDIAAQGEQQALRVQAATRMNTLTGGTARTLVVNVRPDCDIILPTAVTREAERALEVM
                     ARITPYPNGSPAWQDYRARFLERYSMGAIVPLRDLTDPDTGLGFPVGYRGTVLKRPVLA
                     TTRRDDRLLALAQSAALNDRREVVLTEEDIEAMSLGEPTQVPAHVELCFTVLSPSLEDL
                     EHGRFDLVTAGLSLAAGTTTGRFLTMLDQPDRERMTAEYAALPTLAAGAVRGQVSSPPL
                     RIPTRNVGRAPAVVPHVLSVSEHNPDATLDLDDLGVVADSRRLYLLSLSAGQLIESSVM
                     NAVELSSATHPLVRFVTELHRSHTAVLAPFAWGAAARLPFLPEVRVGRTILSAACWRLN
                     ARDLSDDSRDWTFRLTDWRIRYGVPRTVYVGGNDQRLRLDLDISAHRQLLRAELDRHGT
                     VTVHEAPDEAAFGWVGRAHEITVSFASDQPPSPAPVNRTTTVVNHDSSRLPGAGEWAYL
                     KLYGNADRAPELLTVHLPRLLHGWAADAPTWWFTRYNDPDSHLRLRLRLANPNAFGEVA
                     QHVAAWAGELRAEGLLQRVQWDTDEPETGRYGTGPALTAAEQVFAADSAAALSQMALPI
                     SDSLRPAVTAASFVDIADAFLGSPADGQAWLTTNLLKNDGEATTRDVLSAAVRLSAPGP
                     DHAALRALPNGEHLVTTWALRRTALTAYRQALEAHGADPAAVLPSLLHMHHNRAVGIAP
                     DSEAICRRLARAAALSWTARKEGALR"
     aSDomain        complement(14636..14896)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K1J60_RS22735_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.50E-22"
                     /identifier="RREFam001.1"
                     /label="K1J60_RS22735"
                     /locus_tag="K1J60_RS22735"
                     /protein_end="240"
                     /protein_start="153"
                     /score="71.1"
                     /tool="antismash"
                     /translation="VVVDPTCTVRGTRVAVPHQSGTNGPTDTTLRRTQAVEAVLTLART
                     PITVGDLVTKLLGDYPDTPTAVIENMVSSLVAHRVLLTSLHS"
     misc_feature    complement(15361..15377)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.11"
                     /tool="antismash"
     gene            complement(15428..15622)
                     /locus_tag="K1J60_RS22740"
                     /old_locus_tag="K1J60_22740"
     CDS             complement(15428..15622)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="K1J60_RS22740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22740"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_220647796.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.7e-13, bitscore:
                     47.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSLLNDTS
                     DNCTSTCQSACTNSTCIGG"
     CDS_motif       complement(15503..15622)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSL"
                     /locus_tag="K1J60_RS22740_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15428..15502)
                     /prepeptide="core"
                     /locus_tag="K1J60_RS22740_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.50"
                     /molecular_weight="2234.3"
                     /monoisotopic_mass="2232.9"
                     /core_sequence="LNDTSDNCTSTCQSACTNSTCIGG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAQQNPTTTLKAATDYSTNTGSDFDLNIETLASAPVIGSL"
                     /leader_location="[15502:15622](-)"
                     /alternative_weights="2252.4"
                     /alternative_weights="2270.4"
                     /alternative_weights="2288.4"
                     /alternative_weights="2306.4"
                     /alternative_weights="2324.4"
     gene            complement(15693..16940)
                     /gene="fxlM"
                     /locus_tag="K1J60_RS22745"
                     /old_locus_tag="K1J60_22745"
     CDS             complement(15693..16940)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009334866.1"
                     /locus_tag="K1J60_RS22745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22745"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_259407865.1"
                     /sec_met_domain="PCMT (E-value: 2.3e-39, bitscore: 134.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDTPAPMSETDNAPASEQQLRDAMVERLIELGAARSARVVAAFR
                     SVPRHLATPEVDMAKTYEAEFAAVTKTDPTGVNISSVSAPRIQAMQIEQADIQPGMSVL
                     EIGSGGVNAAYLAEMVGGRGHVVTMDIDHDVTRRAEDFLKTTGYDRIVTVITADGEHGV
                     PGHAPYDRIVVTVQAADIPPAWVHQLKEGGRLVVPLRMRGMTRTVAFIRDRERLISDGF
                     ELCGFVPMQGVGENRVRLVLLHDVEGEEIALRLDGLPEPDAEALRVALGMHRVEVWSGV
                     TVAGDESTEHLDLWLTTALDNLPLMAAKIGARKRGLVASASPIGVPTLVDGDSFAYRTA
                     RPTDDPDRYELGAISHGPQARKVADRLAEEIQVWHSDHRTQRAHIEVHPAGTPDDRLPA
                     GRLVDRPHTRVTITWS"
     gene            complement(16961..17131)
                     /locus_tag="K1J60_RS22750"
                     /old_locus_tag="K1J60_22750"
     CDS             complement(16961..17131)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS22750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_22750"
                     /product="hypothetical protein"
                     /protein_id="WP_220647798.1"
                     /transl_table=11
                     /translation="MATEEPDDDTLFDLIGAVGAGINASKDEGLPLDVRALAADLADHT
                     ADRLAQFKKTT"
     gene            complement(17935..18303)
                     /locus_tag="K1J60_RS22755"
                     /old_locus_tag="K1J60_22755"
     CDS             complement(17935..18303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056640.1"
                     /locus_tag="K1J60_RS22755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22755"
                     /product="hypothetical protein"
                     /protein_id="WP_220647799.1"
                     /transl_table=11
                     /translation="MTTVTDRRKAPAVDNQPIDTELIADSTDAALRMKLGTSTRESIDI
                     RTTAVIEQLNRLLGMDLGADEDPDIRQLVRRANKLLELSERPTKETPAFSAFFYMRDVA
                     SLTRRLLWVCPEAGGHAP"
     misc_feature    complement(18403..18419)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            18502..18921
                     /locus_tag="K1J60_RS22760"
                     /old_locus_tag="K1J60_22760"
     CDS             18502..18921
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010469724.1"
                     /locus_tag="K1J60_RS22760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22760"
                     /product="hypothetical protein"
                     /protein_id="WP_220647800.1"
                     /transl_table=11
                     /translation="MKLRFLGKNSTVGDCPTLYATDRDTYLVQGWKIFANDLLMQLEIP
                     EGETAVEVPTELFEYLTKDDLAAGEIRRVEDPIMILTPNGTFVVQGREVTDPEALAQME
                     IPDYETVVEVPKAAITALLEEPRGADLQRRAQPAL"
     gene            18881..19405
                     /locus_tag="K1J60_RS22765"
                     /old_locus_tag="K1J60_22765"
     CDS             18881..19405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056638.1"
                     /locus_tag="K1J60_RS22765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22765"
                     /product="DUF6879 family protein"
                     /protein_id="WP_220647801.1"
                     /transl_table=11
                     /translation="MELISSAERNQLFESFAEDAFHLELRDDYSVPDEDSPFTSWLRGE
                     TVDYSYMEPWTRLIRCVTGEGKTVRRVRVVTEPHTPYIQWEHATTAQNEKAGEEIRWLP
                     RHRLPEGITFPVGGNDWWLYDDRLLAVGHFAPDGRVLGSELIEDPNTVAECVRLRDLLW
                     SAATPHPEYKP"
     gene            19413..20267
                     /locus_tag="K1J60_RS22770"
                     /old_locus_tag="K1J60_22770"
     CDS             19413..20267
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056637.1"
                     /locus_tag="K1J60_RS22770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22770"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_220647802.1"
                     /transl_table=11
                     /translation="MSTQAQEALQALGARLRGFRKDAGFASGRAFARATSWQESKVSRI
                     ENGKQRPSEDDIRVWCETTGQGDQLGDLVAIVRHVDELWLEWRRQLQTGVEKRQRQAIP
                     VYAKTKVFRIWHPTLIWGTLQTADYAAEVFQQGVSYYEIPNDTEAAVAKRLERQQYLYQ
                     GERIFNVLLGEQALYTNFGGPEVMKGQLDRLLAVMRLPRLSLGIVPKSAPTLIWPGNAF
                     SMFDSRLVLVETYSAEFSVSQPREIELYTKAFALLKQSAVYGTAVRDLISTAIQHYDQI
                     PND"
     gene            20288..20467
                     /locus_tag="K1J60_RS22775"
                     /old_locus_tag="K1J60_22775"
     CDS             20288..20467
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="K1J60_RS22775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22775"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_259407866.1"
                     /transl_table=11
                     /translation="MTANWRTSSYTETQNCVEVADHDPTTVMVRDTKARGRGMIEVQPA
                     TWTAFVEHAKQREH"
     gene            complement(20883..23069)
                     /locus_tag="K1J60_RS22780"
                     /old_locus_tag="K1J60_22780"
     CDS             complement(20883..23069)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.5"
                     /locus_tag="K1J60_RS22780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22780"
                     /product="protein kinase domain-containing protein"
                     /protein_id="WP_220647804.1"
                     /sec_met_domain="Pkinase (E-value: 8.4e-46, bitscore:
                     155.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLKDDPTWVGRYRLESRLGSGGMGVVYRACSASGQVVALKVIR
                     RQWAESPEFRARFQLEVAAARMVHSKHTVPIIDADPYATDPWMASRYIPGQSLAARVRE
                     HGPLDEPELRALAWALAGALGDIHRAGVVHRDLKPGNVLLSERGPLIIDFGVSRAVDGR
                     PLTAAGQIVGTPAFMAPEQFTTPSEAGPAADVFSLGCVLVFAATGRSPFDAGSAYASAH
                     LSRHEKPDLSALPESLHDLVADCLRKPPAERPTPEDLLLALVSSEPKRTTARHAAVHTL
                     RIITTRWLNQRVPAWLMTLTVLASAATGIGTVALWPSTPASSPTTRSAEEGWRPWEARL
                     TGNGGIQRCTAYDEVIYCVTGNGSVARINTFDDGRIAWTSAAPADRYANFTSPRGGTVV
                     LGVARGMVFIVRERARELPDDGQEPLRSRIYALDADTGRTLWTRLLPDIAFPEVPLFQV
                     AQLVRVRQTLYITDPVKNEIVAVNVATRSTRWKRPLRTDEVLAATSDGLYALQTLTKRG
                     QHPKRTAITAIEPATGHTAWTTTKNGILDFAASVPGALYLAERTSNGGGARNTAVIRLD
                     TRTRADVRVPVPGGFRCRFAPSITQGATDHYGVADRDTFYLEGDDGETIAVDTKSKTTR
                     WHGEPETPGTLPVPTLLDNQLLYPTSYGEVIAVDTRTGEPLWQTHPRAAAIKRPWGSLS
                     PVMVVNGRLYAVSARNSVFAVDASPPPPTPDQQA"
     misc_feature    complement(21819..21821)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(23200..23215)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.24"
                     /tool="antismash"
     gene            23833..24885
                     /locus_tag="K1J60_RS22785"
                     /old_locus_tag="K1J60_22785"
     CDS             23833..24885
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042699.3"
                     /locus_tag="K1J60_RS22785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_22785"
                     /product="DUF6602 domain-containing protein"
                     /protein_id="WP_220647805.1"
                     /transl_table=11
                     /translation="MTDLLASNDGPSEGQHHDLHDFMEETATELAREYTRITRRSKEDP
                     GTAGDEAESNWQEILKGYLPPSLPVVTKGRILGVDGRSSPQVDVLVLSPNYPKRLLGRK
                     QYLASGVLAAFECKLTLRQRDLSKIGENARLIRDLAPENEPSVYGNLHSSIIYGVLAHS
                     SEWSSHADPEGPDYEFRLDPLRDWPTPLDGALKRLMDRAAHPRDLLDVLCIADLACYER
                     DTRVIPGKEYFSPGDWARLKANHQISDEGEVSTSYFRPARFHSLGNATESALFSFIVKI
                     LYGISWKIPSCQAMAEYWRLSQNEEVRELRCGPSRSWPLSVLSEHVLAKIEAGSLEQGH
                     CWCGWGSKFE"
ORIGIN
        1 agttcgcgag cgtgttgtac gtcgccaacg gctacgccgg ctacagcaag cccaggaggc
       61 agctcaccac ggaccgcacg tttgtcgtgg cgcgcgacgg ctccggtgac tacaggacga
      121 tccagtccgc gatcaacgcc gtccccgcgg acggggtcgc ccacaccatc gtcatcgaca
      181 agggcatcta ccgcgaggcc atcaccgtcc cgagcaacaa gacccacctg accatcaaag
      241 gcgccccggg ggtctcttcc tgggatgtgt acatctacaa cgacagggcc catgggacgc
      301 gccggcccga cggcagcctg tacggcaccg agggcagtgc cacggccacc ttcaaggcac
      361 gcgacctgac cgtccaggac ctcacgatcg ccaacacgtt caatgccaag gcacacccgg
      421 agatcggccc gttcgagacc caggccgtcg cggtggccgc caaaggtgac cggcaggtgt
      481 tcgacaacgt cacgatcaag ggccgccagg acaccctgtt ggtcaagggg aacgcaccca
      541 cggaccaggc ccggcagtac ttctacaact gctacatcac gggcacggtg gacttcatct
      601 tcggcaacgc caccgcggtg atcgaccggt ccgagatcaa ggtggacgac tggcccggcg
      661 gcacgttgct tgcgccgaac accgaccgca ggaagaagta cgggatcctc atcaccggca
      721 gccaggtggg ttccagtggt gtgccgaacg attcgtacta cctcggccgg ccgtggcaca
      781 actcgccgga cgcctggccc caggcggtgg tccgtgacac ccgtctggac tacatgatca
      841 aggaaacgca gccctggacc gacatgatgc ccgactacca ctggcagcag gcccggttcc
      901 gggagtacaa caacagagat aagggagccg gcatcggacc gaacgcaccg aagctgaccg
      961 acgccgaggc cgcggactac accgcacaga agtacctggc gggcaccgac ggctggaacc
     1021 cggtccgctg accgcggccg agacgacagg cacacggccc accggcggca cccccgcccc
     1081 ggaggcgagg tgaaccacgg cgggccggga cagcacgagt gtcccggccc gccgtagggc
     1141 tcccgccgtc tgtcagccgg tgggccacgc cgttcacgcg gaacgcgccc gacgtcgttc
     1201 agcccgacgg tctcgccgca tagagccagt cgagaccgtc gtgtccgacg gcatcgaggt
     1261 gctccgtacg cctcgaccag cgtcatcggg gacgtcacca cctcggtttc ccctcgcgcc
     1321 gcgaggtcga gccaggcgat cgtcttcctg ccgccgcgta ccgcaaggga cagggccgtg
     1381 ttcctcctgc agccagtcga ccagctccag cagccggtcc cggtcccggt cgcgttgcat
     1441 cgcagagcct cggcgacgta cgccgacagg ccccgctcgg ccgcctccgc acgaccggtg
     1501 agtcgcctcg atggcctgac gcgaatttcc gcggtcaagg ggccatggca ggtcgcgggg
     1561 aggacacctc acttcgttca ggcaacaaca tcgtcggccg gccagtgccg cacgcgtgcc
     1621 agggatgtcg tgtacaggag tcacgctcgt cacgctcccg cccacaccac acccctgtgc
     1681 ctgaccatgg gcgcggtcac aatctcttgc tctgcggtgt gagagcggcg caacggaatg
     1741 tcccacgcgg tctaacaggc aggaaaccgg ccgctacggc gggcggacta gcttcgtgac
     1801 atgagggtgt ggatgcccgt acggccgctg cgcggcaagg ttgcctcgat cggcaagggc
     1861 agattaggca agggtggttc agtgcgccgc cacgggggcc gaacgaatcc cgggcgacgg
     1921 ccgatgcctg gctggcgcag catcaggggc cgggtggcgg tggtcatcac ggtcccgatc
     1981 tgcttgctgc tgacggtggc cggtctcgcc gtgcacggcc gcgccgaggc cctcggcgac
     2041 gcccggacga cccgtgccga ggtcggcctc agcctgcgca tccaggccct cgtgcaccag
     2101 ctgcagcgcg aacgtggcct gaccaacggc ctgttgggcg gcgagaagga gttccgccca
     2161 ccgctttccg ccacgcgcaa gcgcgttgac acggcactgc gcggaatgcg caccgaaagc
     2221 gccgtcgagg acgtcgtcca gcggcacttg cggcgtctcg ccgacatccg atccgccgcc
     2281 gacagaggca ccgccggcca ggccgcgacc ctcaccttct acaccagcgc cgtcaacgcc
     2341 ctgaacgccg tcgatccggt ggcggagacc gcgaccggcg ccgaccgcca actgcgcgac
     2401 gggctggccg cgttgcgcga gctggctgcc gccaaggagt ccgtcgccct cgaacgcggg
     2461 ctcctcaacg gtgtgttcgc ccaaggtgcc ttccagggcc gtgagtacat cgacttcacc
     2521 gaggtgcgag ccacccgcgt cgccgccctc acccgcttcc ggcaggtcgc caccgcacct
     2581 cagcgcgcgg cactggagaa ggccttcgcg accgaggacg ccgaacgcgc caccgcctac
     2641 gagaaacaga cggaaggcgc cgccgacggc tccccgctgc gcgccgacgc ccgcacctgg
     2701 tgggaggcga tgaccgtact cgtcgacgat ctgtacgccg tccagcagtc ggtcggtgac
     2761 gacgtgcggg accgggccga ccggctcagc cacgacgccg aactggccct cgccgcctat
     2821 ctcgtcacgg gcacgctcat cgccgccctc gtcgcgggcc tcgccgctgt cgcctcccgg
     2881 tcgctcacgc gcccgctccg tggactcgcc gagaccgctc acgacgtggc gcgccgccga
     2941 ctgcccgcag ccgtcgcccg tatccagcag tccccgcagg actccgctca gctcctgacg
     3001 ccggaggacg cgcaggacac ccccgatgca cggctgctgg gcggtgcggc cgagatcgcc
     3061 gaggtcgcag cgtccctgca gcaggtggaa cacacggccc tccagctggc tgcccagcag
     3121 gccggcctgc gtcgcaacac cacggaatca ctcgccaatc tcggccgccg gaaccagagc
     3181 ctcgtacgtc gccaactcgg cctcatcacc cgcctggaac ggcaggaact cgacccggac
     3241 gccctcgccg agctcttcga actcgaccac ctcgccaccc gtatgcggcg caacgccgaa
     3301 agcctgctgg tcctggccgg gcagaatccg ccaaggccaa cggcagcacc cgccgacggt
     3361 ctggaggtcg tccagtccgc agtcgccgag gtggagcagt accgtcgagt tctgatcgcg
     3421 accgtggagc cggtgcgggt gcgtgggcac gccgtcgcgg atgtcgccca cctcctcgcc
     3481 gaactcatcg agaacggact gaatttctcg cccccgaccg aaccggtcga ggtgcacggc
     3541 tggtacgaca ccgaggacga cacgtactcc ttcggtgtcg tcgaccacgg catcggcatg
     3601 tccgaagccg acaaagcacg tgcgggcgcc ctcctctccg actccggcga ggaggccctc
     3661 gttgccgcac ccacccggtt cctcggccac ctcgtcgtcg gccgactcgc ccaccgcctc
     3721 ggtgaaggcg ctcaagtcca cctcttcgac actcctggcg gcggcctgtc cgccctcctt
     3781 gccctccccg ggcgcctgct cgcccccgtg gaggacccct ccacctcacc cccacccgcc
     3841 aggcccgctg tctcctccct gctcaacggc ttccgagcag gtgtcgcccg cgccgaagcc
     3901 agaaaccccc aaggagcgtc atcgtgacca ccgccgtcca gagtttcggc tggctcgtct
     3961 cggagttcgt gcgcaccgcc gacggcgtca ccgatgccgt cgccgtttcc tctgacggcc
     4021 tgctcatggc cgcctcggac agtctcggcc gagatcgcgc cgaccacctg gccgccgtcg
     4081 tctccggcat caccagcctc gcccagaacg cggcgacggc acacggcttc cacggcatga
     4141 agctcgtcat gatcgaaatg ctggggggct tcctcatggt cggtcgtatc cgcgacggca
     4201 gctgcctcgg cgtcctcgcc gccgaagggt gcgacgtggg cctcgtcggc tacgaaatgg
     4261 ccgtcctcgc cgaccgcgcc ggcgagctgc tcaccccgca gttggtacgc gaactgcact
     4321 ccgcgcccag gtgagcccat gggaggctct gcgctcacgg tcgatcgctg cggcgtggcc
     4381 ggggccgccg ctggacgagc tggcgtgaca ggagtggttc gtctcgctgc tcacggtaga
     4441 ggacgaggcg ccggacttcc ctgcgcaggc cgtcgtggcc ggtcccacga cgcgtcaggc
     4501 gggcgcggat cttcggtacg acgtcggccg ccggcggcgt gagcgccgcg tgagcgccgc
     4561 gtgagcgggg acattgagac cgtcgtcctg gacagcgagg ggcggtcggc ctgggtggcg
     4621 aggaccggaa ggttctggcg atgttccagg tgttccaggt gttccacgac atgggagcgg
     4681 accttgtcgt cagcgccaac accatggtgg aggtgagcca cgccagggtg aacctgcccc
     4741 gactgcaatg ggcgttctcc cgggtcgagg tggagccgat cacggaggca gcggccgagg
     4801 cggcggccca accgctcaag ggcgccggtc tgcacggaca caagtacgcg atcgacgcca
     4861 ccgtcgcgga agcggcctcg cgtcagcctg gcccggtcgc cgtcctcacg ccggatgtca
     4921 atgacatgac ccggctgcgc ggccaacgga tggccgtagc cggccggccg cctcccaagc
     4981 gaaggcttca gctgtgatgg tgtgcgcttg gagggggcag tggacgctgc cggcgtcgag
     5041 cgcaccgcgg ctccgaaggc cacgcgcttc cccggggcag cgcactgcgc cgcccgcctt
     5101 cccagaccag cacgggaccg tccgccgccc accgcggccc cgagcacttc cctgtccgtg
     5161 ccatcgctca cgagatggga gggcaccact gacaacggct ttgagctgcg gcttcgccgg
     5221 gcgggggagg gtcccatgcg gaggtgacgg ctacggctgg atggtcacca tgcggtagtt
     5281 ggaactgtcg gagtcgcccg cccagccgac tgtcttggcg ttccggtatt tacaattggt
     5341 gtccgagtag gtgtaaagaa gcggcctgtc ctccaccgag tcgtaggccc tcaccgctac
     5401 ttgcaacttg gtgtcggcgg gcctggtgcc cccgttggcg gtccgcgtcg cgtagttgac
     5461 cttcacgcag tttccgttgt ccacacggat gctcttgaca tccgtcgcct tgttgttgac
     5521 ctggacacag gcgtagcgag agcccttctg gccgacgctg cagtccgccg ccgcggccgg
     5581 tcccgccgtg agggccaggg tcgctgccac cgccagagtg ccgacggtgg ccatgccgat
     5641 aagacgtttg ttcattgttg ctgttccgtt ctgctcagtt ctcagttagc tgcgggcgtc
     5701 ggcgcgaagt ggaccgggat gtactggtcg aacgaccggt cgtcggtggc cgtgaagtgg
     5761 gcgcgagccg tacgggatcg ccgctgaagc atccggccgg tcacgaaggc ttggcgggag
     5821 gcggcgtcta ctgctgcggc gagtgtggga gcgagggcgg ccagcagtcc gacggcctca
     5881 ctcacgtacg ggttggacgg tgctgaggcc gataccgaac ccggtggctc ccaccgagcg
     5941 ggtgccacgg aggcaggtac cggagcaccg ggctcgggcg gcctcagctc agcctgaacc
     6001 agtagttggt ccattgctga tcagtcggca cggtgccctg ttccggggcg ttgccgaccc
     6061 atgtgccgtc gcagttccgg ccgctgtaga gcattccgcg gagagtgacc ggattgctgt
     6121 tgacggtggg ggaaaccctc acatttgtcg tcctgtccac gcctggggtg acctggacgc
     6181 acccgtacct ggagttgtac gcggaccaca gcagaacact gttcaccccg gcgggtaccc
     6241 gcgtcagtgc cacgggccag ccgttgctcg gcgcctgcgc cgccgtcgcg ggcgccgcga
     6301 aggccatgcc gacgatgctc gcggccgcga ggaccgcgcc catccccgct gccctcctcc
     6361 tgccccatgc agaagtcgtc accatgtctc cttgatacgg aaaggccatg ggacgggctg
     6421 caaggcaact ctcccatgcg gtcggtcact acccggggac tcattgccgg tgctgaagca
     6481 ccagcgctac ggcggcgaac gatcgcgttc gaccgcgcga tccgccaggt ggtcccggtg
     6541 atcacggagt gtggcacgtg aggcgggaat ttttattgag agttcaagga ggtggggtga
     6601 aggtgagctg tcaattcgct ttccacatcg gtctgttgcc gcgtcgccgg cgtcgccagc
     6661 gtcgccagcg tcgggcgcgc ggccgagcgc acgaccaagg ccgaagtgac caaagccgtc
     6721 cgcgagatgg agcgggcgcg agacgacgag aacctcggga agccgggcca gggctggacg
     6781 gcccgggcct ggctggagca ctgggtcgag aacatcgcca agccgtacgt ctccgagaac
     6841 acgtacgacg gggacgaggt cgacgtacgc gttcacttcg tgcccggcct gggcgcccac
     6901 aagctcgaca cgttggagcc cgagcacctg gagtgcttcc accgaaggac gcagaccaag
     6961 gctccccgtc tcgaagagga gcacatcgag ccgtacacga tcgaagaggt gcagagcctc
     7021 ctcgtcgagg cggccaagct ccgcgacagc gcgcgttggg tcgtcgccct ggctctcggc
     7081 ctccggcagg gtgaggccct ggggctgcac tgggaagacg tcgacctcgc cgccgggtac
     7141 gtccgcatcc gtaagaaccg gcggcgcccg aagtacgcgc acggctgcgg tgccgacccg
     7201 tgtggccgca aggcgggcta ctgccctaga aggagcagac gcgccgcgag cacaagtcca
     7261 ccaagtcccg tgcggccggc gcaccatcgg tctgcccgat ccgctgatca agattctccg
     7321 ccggcaccag gaagcccggg agcgggaacg gatcagggcc ggtgcggact gggagaacaa
     7381 gggatacgtc ttcgcctcgc cggttggcgg gcccctgagt ccccacaccg acttccacgt
     7441 ctggaagcgg ctgcttcggg acgcgggcgt acgggacggc cgtcttcatg acgctcgcca
     7501 caccgccgcg accgtcctcc tgatcctcgg cgtccctgac gtcgtgatcg actcgatcat
     7561 gggctgggag cccgagggag cggcccggat gcgcgcccgg tacacgcacg tgacgtggac
     7621 catgctccgc aaggccgcgc agcagatcgg cgatgccctc tgggagctgc cgggagttgg
     7681 cgggactacc cgggaccacc gaacccgacg ggaagccgga cggaaaaccc acctgagacg
     7741 gaaagtgaga cggagcacgt cgaagggccc caccgcgaac ggtggggccc ttcgacatcg
     7801 tgcccggtga ggcactggcg gaggatacga gattcgaact cgtgaggggt tgcccccaac
     7861 acgctttcca aatgttcgtc tgggggtccg gcggggaccg tgggcgtcct gacctgcggt
     7921 ggcgcgagtg ataggaggcg gttcggacgg ctccggacgg gggtgaatga gaccaaaact
     7981 gagaccagag gtggccacgt tgcccctgat gagcggcggt cccgaggcgg tgtgagggtc
     8041 acagcggcaa cggaacctcg cacggagatc agctggcgtt ctcctcattg ttcaggagcc
     8101 gcatcacgta tacgtgctgc tccgggtgcc atgccagccg cgctatcacc gcggctgaat
     8161 caggattcac ccatcgccga gacagaacga tgtaccagtg cggacgaccc cagagacgtc
     8221 ggcccgtgac ggcgcgacgc accgagcgga ggttcaaacc gctgcccaac ggtgagcccc
     8281 agctccggga actgttcgcc cgcctcaagc gcaaggggaa agtcctggtc gtggtcgacc
     8341 agccggtttc catgcgcacc ctggcggtca ccgtagcccg ccctgcgatg ggcggctgct
     8401 gccacgcgag actcatctgc gcgctggcct cggccggagc tttcgcgacg agggtcgcgt
     8461 cgacggcggc gtcagggatg aggcaaagtt ccgggcatgg ccgcctccga gaagcccgag
     8521 aagtcacacc agcttcctga atccgtccgg gagcaccttg tagccatcgt gttcgacacg
     8581 aactcattcc cttccggggg gcttgatctt cacgtcctta aggagtgggc gaggcgtgca
     8641 gaactcgctg acctggaggt atggctgccc gagccagttc tatgggagct ggcggagcac
     8701 gcggcagccg cttgggagga gcagcgggca agtgtgcgcc gggcacagaa gtccatgagg
     8761 cgagcgggcc ttgaggttcc gtcggaggcg ccgtacaact cgcgggagac cgtcatggcc
     8821 accgtggaat ccgtggtgac cacgctcaat cccgccgtgc gcattctcac gatcgacccg
     8881 gacatcgcgc gggaggctct taaggaccag atcctgttgc gccagccggc gaagaagaag
     8941 caggacgtca aaacgggagc tgcggacagc gcatggctcc ggcaagtact gaaagaagcc
     9001 ggccggaacg tggaccggtt catcgtcgtg ggcagcgaca aggacgtcga gcaagcgttc
     9061 aaggcgtggg gcttgcagaa gccgcacatg gtcaagttgg agcacctcga cgcggcactg
     9121 ttcgtacttg acgagttccc tgaggaggag atggctagtt ccatcgttgc gttcttgcag
     9181 gtccacatcg atgcgcctga atcgggggag gggcgagacg ctgccctggt actgggggag
     9241 atcacgaatg gggacgaagt cgttggggag tgggagtacg accaggttca ggacgtgagc
     9301 gtagggcgca tccatcatgt cgcgggtttg agtgatctca cgatcaaccg tttgaccggc
     9361 atcgtaaaag cgcaagtgtt cttcagcgtc gaactcgagt acaccggtat gaggatcgat
     9421 gagaacggcg agactgtaac tcactctgag acattccccc atgcaatggt cagagacgtt
     9481 ctcgcgttca cgatcgatga cgacgggatg gtgaccgaag cccgcagtga gacaggtcaa
     9541 gcccacgcct tcagtggaaa ttccgccttc tccgattcgt gggacgcctt cgcggcactg
     9601 cttgaggcta tgtcgttgat ccctggcgtc gaccgcgagg agctcgatgg cgccgagatc
     9661 ggatgtgaac tgacttggca ggtcggaggg tgggaactga ctttcacctc ggaggaaggg
     9721 cacggggacc cgcactggag cgcctctgcc acgttgtcca aggactctat gtcgcattcg
     9781 gcggaattcc ggtgcgaatg ggacgggagc ctcgccccgt atgaaatgcc cgacctcctt
     9841 ccggcctacg tgatcgctgc cgaagacgaa gagtcgtatc tcaactcagg cgagtggacg
     9901 gcgccagcct gggtgctaag caagatctgg ccttcacccc accgccggga gcagatgggg
     9961 atctcccagt cttccttctt cgattctgtc cgtgagctat ctaacaaaga gccggatgcg
    10021 cagttctgaa acctgatcgc cctcttgcgg cagggcttcg gcgcagggct tcggcgtagt
    10081 cgcgtgacgt ccggttcgtg atcatccgag gccgagtagt gcgagggggc ggcgagggtc
    10141 gcgggggttg cggcggaggc cggccgcgat gttcttcatg ctcccggcca ccgagaatcg
    10201 tctccctggc cgccctggag tagatggcct gttggcgggt ggtgaagccc atccggttcc
    10261 agtggaagag gatgtgccgc gccaggatgc cgcgcgagcc gagctgaagg ttgcccgcgc
    10321 gtgctgcgtc tgcgagggct tggccgcagt gctccaaccc ggtcacccag ttcccgagcg
    10381 gcgcgagtgg gccgtcggtg agggcggggc cgacgtcgag cgtcaagagt cgccgtaccg
    10441 gggccaccat gctgctgacc tggtcggggt ctatgtctgt gggcagtggg cgtagtgctt
    10501 cgacctgccc ccatacgtct ccctgttcgc cccactccag cccggcggca cgcagcagca
    10561 gagtggtggc gaggagggag gtctctttgg ggccggggag cccgctggtg ctgtcggtca
    10621 cgtgctggtg gtagtcgagg attccgacgc tgtcggtgtg gaacagggtg tgggcgagtg
    10681 ccatgccgtg cgggccgccg aaggcgatgg tttccggctc gtacaggaag ggccagcacc
    10741 gcttggcgac gcccaaggac agggcgttgt cgagtacttc ggtgaggtgc gcgacggcgt
    10801 cctccatccg tgtacccggg cccggctgga cgcgtagacg ccagcagggg tgcttgcgca
    10861 cgaaccacca tgctccgatc ggcccggtgc gtaaggcggg caggaggtag gtgcggaagg
    10921 ttcgttccgc tgtggggtag tcggtgaact cgatgttcac ctggtgccag ctgccgagtt
    10981 gggggtcgag tgctgaccgg ccggcgtccc ggtagcgctc ggtggcctcg gcgagatgct
    11041 cgggcgacgt ctgcgctcgt tcggcggctt ccgtgagcgg ggtgccggtg aggacggcca
    11101 ggatggcctg ctcgatggtg ctgctatcgg gcaggttcat ctagatcctt ccggtggtgg
    11161 ggtcagatga ggaggaggca ggcgtcccag tcgctggttg ggagggtgcc ttcttgaatg
    11221 ttctggaagg cgagggtcgc gccgaccgag ccgttgagga agccggtctc ggctggggat
    11281 tcggtggtca ggaagcgttc gctgagctgt ggcaggtggt ggacgaaggc tcgtggttcg
    11341 tcggcgtcat gggtgacgcg ttggaggacc cggagcaggc cgccgaggcc atggcacagg
    11401 ccgcggctgg tgagttggtc gagctgggtg gggtcggcca ggcagtagag gagtgctcgt
    11461 tcggccatgc gtttgcggtc ggggtcgttc agggcaaggg cggcgagttg ttgggcgcgg
    11521 gccagaccgg gggtgccgta gcaccaggaa ggggcggcca ggtgtggggg cacggtggtg
    11581 gtgttggtga tccagcgtgg ccagcgggtg ccgcggtggt cgcttacgcg tatctggtcc
    11641 agccagctgc agatccgcag catcgccttc tcgtggccgg gcacggtgat gccgcggagc
    11701 ttggcgagtg cgaggagggc gagcgggccg gtgatgccgt gggcgaggcc ggcgttggcg
    11761 tggccgtcgg gggtgcgagc actgaggttg acggggctgt ggctcaccca ccagcccagg
    11821 cggggtcgcc cgttggcggt gtggagcggc tcggtcaggc gcaccaggta ctccagcact
    11881 cccttgagct cgtcgccctc gggggcgcgg cgtaggagga gggcgccgag gccggtcagg
    11941 ccacgcagga ggtcgtactc ggcaaaggtg gtcggctcgc cgcagtcgat gcgggcgtgt
    12001 gctgctgcca gtcggtgtcg gatgtgggtg gcaacgatgc ggtcgagggt ctgcagggcg
    12061 ccggtgtatc ggatgttgtc gacggtggtc cagtgcagca cgtacgtcat cgcgggcgcg
    12121 ccgaggaaca ggccggtctc gttgccgtcc aagagcgggc cgatgtcggc gagttgctga
    12181 tgggcggtct tccaggatcc ggtgccctgg cgagcgcgtt cgacgtggag cagtgcaatg
    12241 ccgagggagc ctcgggcgag ggactgccgg agggtggcgt ccgtgtccag ggcgggcgga
    12301 gcggtggtca ccgcagggct ccttcttttc ttgcggtcca ggaaagggcg gcggcgcggg
    12361 ccaggcggcg gcagatggct tcgctgtcgg gggcgatgcc gacggcccgg ttgtggtgca
    12421 tgtgcaggag ggacggcaga accgcggcgg ggtcggcacc gtgcgcttcg agagcctggc
    12481 ggtaggcagt cagggcggtg cggcgcaggg cccatgtcgt gacgaggtgc tcaccgttgg
    12541 gcaaggctcg cagggccgcg tggtcggggc ccggggcgga aaggcggacg gctgcggaga
    12601 gtacatcgcg ggtggtggct tcgccgtcgt tcttcaggag gttcgtcgtc agccatgcct
    12661 gtccgtccgc tggggagccg aggaaggcat cggcgatgtc gacgaaactg gcggcggtaa
    12721 ctgcgggccg gaggctgtcg gagatgggga gggccatctg tgagagggcg gcggcggagt
    12781 ctgcggcgaa gacctgttcg gcggcggtga gagcggggcc agtgccgtag cggccggtct
    12841 ccggctcgtc ggtgtcccac tggacccgtt ggagcaggcc ctccgcacgc agctcaccgg
    12901 cccaggcggc gacgtgctgc gccacctcac cgaaggcgtt cgggttcgcg aggcggagtc
    12961 gcagccggag gtggctgtcg gggtcgttgt agcgggtgaa ccaccacgtc ggtgcgtcgg
    13021 cggcccagcc gtggaggagg cgcgggaggt gcacggtcaa cagttcgggt gcccggtcgg
    13081 cgttgccgta cagcttcagg taggcccact cgccggcgcc gggcaggcgg ctggagtcgt
    13141 ggttgacgac ggttgtcgtg cgattgaccg gtgcggggga aggcggttgg tcggaagcga
    13201 aggacacggt gatttcgtgg gcgcggccaa cccagccgaa cgccgcctcg tcgggcgctt
    13261 cgtgcacggt caccgttccg tggcggtcca gttcggcgcg caggagttgg cggtgggcgc
    13321 tgatgtcgag gtcgaggcgg agccgttggt cgttgccacc gacgtacacg gtacgaggca
    13381 cgccgtagcg gatgcgccag tcggtgagac ggaacgtcca gtcgcgactg tcgtcggaga
    13441 ggtcccgtgc gttcagccgc cagcaggcgg cggacaggat ggtgcggccg acgcggactt
    13501 cgggcaggaa cggcagccgg gccgccgcac cccaggcgaa gggggcgagg acggcggtgt
    13561 gagagcggtg caactcagtg acgaagcgga cgagggggtg tgtggcgctg ctgagttcca
    13621 cggcgttcat gaccgaagac tcgatgagct gtccggcgga gagggagagc aggtagaggc
    13681 gtcgggagtc ggcgacgacg ccgaggtcgt ccaaatcgag ggtggcgtcc gggttgtgct
    13741 cgctgaccga gaggacgtgc gggacgacgg ctggggcgcg gccgacgttg cgggtcggga
    13801 tacgcagggg tgggctggac acctgcccgc gcacggctcc ggcggccagc gttggcaggg
    13861 cggcgtactc ggcggtcatc cgctcgcggt ccggctggtc cagcatcgtc aggaaacggc
    13921 ccgtcgtggt gccggccgcg agggacagac cggcggtgac caagtcgaac cggccgtgct
    13981 ccaggtcctc caatgagggg gacagcacgg tgaagcacag ttcgacgtgc gccggaacct
    14041 gggtgggctc gccgagtgac atggcctcga tgtcctcctc ggtgaggacg acttcgcgcc
    14101 gatcgttcag ggccgccgac tgggcgaggg cgaggaggcg atcgtcgcgg cgggtcgtgg
    14161 ccagcacggg acgcttcagc accgtgccgc ggtagccgac ggggaagccg aggccggtgt
    14221 ccgggtcggt gaggtcgcgc agggggacga tcgcgcccat gctgtagcgc tccaggaacc
    14281 gagcgcgata gtcctgccac gccggagagc cgttcgggta cggcgtgatg cgggccatga
    14341 cctccagggc acgctccgcc tcccgcgtga ccgctgtcgg caggatgatg tcgcagtcgg
    14401 ggcgcacgtt cacgaccagg gtgcgagcgg tgcctccggt gagggtgttc attcgcgtgg
    14461 ccgcctggac gcgcagagcc tgctgctcac cctgggcagc gatgtcgtgc agggtgagga
    14521 gctggtggat ctttcgcagc tcctcggctg tctccgcctt atctgatgtg gcggtggcac
    14581 ctgtggcgtc cagccgcgcg atgagatgtc cgagcgcgtc gtcgcatgtc atgggggagt
    14641 ggaggctcgt cagcaggacg cgatgggcga cgaggctgga caccatgttc tcgatcaccg
    14701 cagtcggcgt atccgggtag tcgccgagga gtttggttac gaggtcgccg acagtgatcg
    14761 gcgtacgggc caaggtgagc accgcttcca cggcttgggt tcgtcgcagt gtggtgtcgg
    14821 tggggccatt cgtgccggac tggtgcggta ctgccacccg agtgcctcgt accgtgcagg
    14881 tcggatctac caccacgggc aggcgccgca gcacctcccg gttgccttcc agggcggtga
    14941 tggcggcgtt caaccaatcg gcatcggccc gggcgaaagc acggtgcccc ttcccccatt
    15001 tcacccgagc ggtgccgccg atgctcacga gggcggggcc ggcgaacagc ccgaacggtg
    15061 tggcgcggtg ctgcatgcgc agcaggtagc gggcgagcga ggccgcggtg cgccggacgg
    15121 agcgcggccg ttgccgctct ccgtcgagca cgtcgcggat ggcggaggcg agtagcggcg
    15181 cggcgaactc gattgcggca gcccgggtgt cgtccgccca gacctgggcg atccagtcgc
    15241 gccagcgctc gacgtcggcg ggggtttccc catccaggtc gggccaagga ggaagcgtcg
    15301 ccgccagcgg gaagactgat gcgcggatca tgctcgcgtc gattgcgtgg tacatcgctg
    15361 tgcctccttc ttcgtcacgg cggtgcgcgg ggccgggcgg gtcagatttc gcccggcccc
    15421 tggtgggtca gccgccgatg caggtgctgt tggtgcaggc ggactggcag gtggaggtgc
    15481 agttgtcgct ggtgtcgttc agcagcgagc cgatgaccgg ggcggaggcg agggtctcga
    15541 tgttgaggtc gaagtccgac ccggtgttgg tgctgtagtc ggtcgcggcc ttcagcgttg
    15601 tcgtggggtt ctgctgtgcc atcacgtact cctcacggga aaaggcgggt gggatgtgct
    15661 gtgccggcct ggtcgtggcg ccgccgacgg cgtcacgacc aggtgatcgt gacccgcgtg
    15721 tggggtcggt cgacgagacg gcccgcggga agccggtcgt ccggcgtacc tgccgggtgg
    15781 acctcgatgt gcgcacgctg ggtccggtgg tcgctgtgcc agacctggat ctcctccgcc
    15841 aggcggtccg cgaccttgcg cgcctgcggc ccgtggctga tcgccccgag ctcgtaccgg
    15901 tcggggtcgt cggtggggcg cgcggtgcgg taggcgaagc tgtctccgtc caccagcgtg
    15961 ggcaccccga tcggcgacgc ggaggcgacc agaccacgct tccgtgcgcc gatcttggca
    16021 gccatcaagg ggaggttgtc gagggcggtc gtcagccaca ggtccaggtg ctcggtggac
    16081 tcgtcgccgg ccaccgtgac gcccgaccac acctcgacgc ggtgcatgcc cagagccaca
    16141 cgcagggcct cggcgtcagg ctcgggaagg ccgtccaggc gaagggcgat ctcctcccct
    16201 tccacgtcgt ggaggagcac cagccgcaca cggttctccc cgacgccctg catcggtacg
    16261 aacccgcaca gctcgaaccc gtcactgatg agccgctccc tgtcgcggat gaacgccacc
    16321 gtgcgggtca tgccacgcat cctgagcggg acaacgagcc gaccaccctc cttcagctgg
    16381 tggacccagg cgggcgggat atcggcggcc tgcacggtga cgacgatgcg gtcgtacggc
    16441 gcgtggccgg gcacgccatg ctcgccgtcg gctgtgatca ccgtgacgat ccggtcgtag
    16501 ccggtcgtct tgaggaagtc ctccgcacgc cgggtgacgt cgtggtcgat gtccatcgtg
    16561 acgacgtggc cccgcccgcc caccatctcg gcgaggtagg ccgcgttcac tccgccggag
    16621 ccgatctcca ggacgctcat ccccggctgg atgtccgcct gctcgatctg catggcctgg
    16681 atgcgcgggg cggacaccga gctgatgttc acgcccgtcg ggtccgtctt cgtgacggcc
    16741 gcgaactcag cctcgtaggt cttggccatg tccacttcgg gggtggccag gtgccggggt
    16801 accgaacgga acgcggccac gacgcgggca ctgcgcgcgg cgcccagttc gatcagccgc
    16861 tccaccatgg catcacgcaa ctgctgttcg gatgcggggg cgttgtccgt ctcggacatc
    16921 ggggcgggag tgtcattcac atgcattctc cttctcggta ctacgtcgtc ttcttgaact
    16981 gggccagcct gtctgcggtg tggtcggcca ggtcagcggc gagtgcgcgc acgtcaaggg
    17041 gaaggccctc gtctttactg gcattgattc cggcaccgac ggcgccgatc aggtcgaaca
    17101 acgtgtcgtc gtctggttcc tcggttgcca aggcggctct ctcttctcgt ggcggtgcgg
    17161 cccgctcccg ctgtgacctg tccttctgag gtcggggata cctccagctc gaacagcggg
    17221 agcgggggtt gaaggcccgc ccaagacgcg gccgttctcc tacgcgacgt gggcgggcgg
    17281 tctgttgagt ggtgctttgg tgggccactg gccgagggga cggggctgtg cgggagccgg
    17341 ggcattccgc tggcgggcgg cacgctcgct catcgtccag tggagctgtt cgagcctgaa
    17401 gacacaccac tggcaggcac agagaggaaa cgccgtgccc gccaccgcga tctcgcccac
    17461 ctcggtcacg gggacgttcg tctgctcgca cctgaagcag ctgccgttcg cccagtcgaa
    17521 acggctccac aactctcctg gcctcacccc catggcgggc cccctcctgg gagatggggc
    17581 atcgggttac ggccgacgag gggcagaaag gcgacggggc gcgcatgcca cacgaaggag
    17641 cacggccccg ctgcgagcgg cagcgtgaaa tccacaccca gttgaagagc tgagacagcg
    17701 tccagccagc tctgggcacg tcggtccacg agaaggtcga tgaaggccgg ctcagcgacc
    17761 gaggcgatga cgcggacttg aatgcgtgcc catcgcacag ccgaagcggc ggtcggctgc
    17821 gcggcacagc tgatgcgccg cccgtccgta tgacgccact cgcaccagaa cccggactca
    17881 ggctcgcaga cggcgcgtgt cggcgcggga gaggcgtgaa ggagcacggg gtgatcaggg
    17941 cgcatggccg cctgcctccg ggcagaccca cagcagccgg cgggtaagac tggcgacgtc
    18001 gcgcatgtag aagaaggcgc tgaaggccgg cgtctccttc gtgggacgct ctgacagctc
    18061 cagcagcttg ttcgcccgtc tgaccagttg cctgatgtcg gggtcctcgt ccgcgcccag
    18121 gtccatgccg agaagccggt tcagctgctc gatgacggcc gtggtcctga tgtcgatgct
    18181 ctcgcgggtg gaggtgccca gcttcatcct cagggcagcg tcggtgctgt ccgcgatcag
    18241 ctccgtgtcg atgggctggt tgtcgacggc tggagccttg cgtctgtccg tcacggtggt
    18301 caccacgcat ctcccctcgg taccgcaacg tgcggcggct gcctcggttg ctcgggttcg
    18361 gagacgaacg tagagcggcc gtcacccaag tcccaaggag attgcgcgag tttgcagcaa
    18421 gccgattgac ggcccacaac agtccatcga ccatcgtcat gtcgcgcaat cccaagcaag
    18481 gcagcagaca ggagaaccac catgaagcta cggttccttg gtaagaactc cacggtcggc
    18541 gactgcccga ccctgtacgc cacagaccgg gacacctacc tcgtccaggg ctggaagatc
    18601 ttcgcgaacg acctgctgat gcagcttgag atcccggagg gggagacggc ggtggaggtg
    18661 cccacagagc tgttcgagta cctcacgaag gacgacctgg ccgccgggga gatcaggcgc
    18721 gtcgaggatc cgatcatgat tctcacgccg aacggtacgt tcgtcgtcca gggccgcgag
    18781 gtgaccgacc ccgaggctct ggcccagatg gagattccgg actacgagac cgtggtcgag
    18841 gtccccaagg ccgcgatcac cgccctactg gaggaaccgc gtggagctga tctccagcgc
    18901 cgagcgcaac cagctctttg agagcttcgc ggaggacgca ttccatctgg agctgaggga
    18961 cgactactcc gtccccgacg aggacagccc gttcacgagc tggctccgcg gcgagaccgt
    19021 cgactactcc tacatggaac cctggacgcg gctcatcagg tgtgtcacgg gtgaagggaa
    19081 aaccgtccga cgcgtccgag tggtcacaga gccgcacacg ccctacatcc agtgggagca
    19141 tgccaccacc gcccagaacg agaaggccgg cgaggagatc cgctggctgc cccggcaccg
    19201 cctgccggag ggcatcacct tccccgtggg aggcaacgac tggtggctgt acgacgaccg
    19261 cctgctcgcc gtgggccact tcgcacccga cggcagggtg ctcgggtcgg aactgatcga
    19321 ggacccgaac accgtggccg agtgcgtacg cctacgggac ctgctgtggt ccgccgccac
    19381 cccgcacccc gagtacaagc cctgaccgac ccgtgagcac ccaagcacaa gaggcactgc
    19441 aagcgctcgg tgcccggctg cgcggcttcc gcaaggacgc cggattcgcc agcggccggg
    19501 cattcgcgcg cgccacctcg tggcaggagt cgaaggtctc ccgcatcgag aacggcaagc
    19561 agcgccccag cgaggacgac atccgcgtct ggtgcgaaac gaccggccag ggcgaccaac
    19621 tgggcgacct ggtcgcgatc gtccgccacg tcgacgaact gtggctcgaa tggcgccgac
    19681 aactccagac cggcgtcgag aaacgacagc gccaagccat cccggtgtac gccaagacca
    19741 aggtcttccg catctggcac cccacactca tctggggaac cctccagacc gcggactacg
    19801 ccgccgaggt cttccaacag ggcgtcagct actacgagat acccaacgac accgaagcgg
    19861 ccgtggcgaa gcgactcgaa cgccagcagt acctgtacca gggcgagcgc atcttcaacg
    19921 tcctcctcgg cgaacaggcc ctctacacca acttcggcgg cccagaagtg atgaagggac
    19981 agctcgaccg cctcctggcg gtgatgcgcc ttccccgcct cagcctgggc atcgtcccca
    20041 agtccgcccc gaccctcatc tggccgggca acgcgttctc gatgttcgac agccgacttg
    20101 tcctcgtcga gacctactcg gcggagttct ccgtctccca gccccgagaa atcgagctat
    20161 acaccaaggc gttcgccctc ctgaagcagt cagcggtcta cggcaccgcc gtccgagacc
    20221 tcatctccac ggcgatccag cactacgacc agatcccgaa cgactaggag agcgcaccgt
    20281 gcagccgatg accgcgaact ggcgaaccag ctcctacaca gaaacgcaga actgcgtcga
    20341 agtagcagac cacgacccga ccacggtgat ggtccgggac accaaggcac gtggccgggg
    20401 aatgatcgaa gtccaaccag ccacgtggac ggccttcgta gagcatgcca agcagagaga
    20461 gcactgatgg cgttcgcgta gatagggcct tgtgaacaat gcggattatc cctcagttgt
    20521 cagatcagcg ggagttgtcc cgtctcaatt gatctggttc cgagtcgggc tcctgacatg
    20581 gggcgaccag ttcagccgag acgtggagac gccgggaatc tcagatgatg tggccccggg
    20641 tgggtgaatg ccggatgctg tctcagctga tctggcccgc ctctgctgtt tcgaactgag
    20701 atcacgttgt gggccacgcg ttcagtattt ccgaggggct gttgagggca gactggagga
    20761 caagcgcggc tcgttgggac gcagggctgg ctcatatttc cgttcggggg gacctcaccc
    20821 cgctccttca ttcgtgtgag gagcggggca cttgtcacag acgcccgtca gcggcaggag
    20881 gatcacgctt gctgatcagg ggtgggtggg ggcgggctcg catcgaccgc gaagacgctg
    20941 ttgcgggcgg agacggcata cagcctgcca ttgacgacca tgaccgggct caatgagccc
    21001 catgggcgtt tgatagcggc ggcacgcggg tgggtctgcc agagtggctc gcccgtacgg
    21061 gtgtccacgg cgatcacctc tccataggaa gtggggtaga ggagctggtt gtcgaggagg
    21121 gttggcacgg gcaacgtgcc aggtgtctcc ggttcaccgt gccaccgcgt ggtcttgctc
    21181 ttggtgtcca cggcgatggt ctcgccgtcg tcgccctcaa ggtagaaggt gtcgcgatca
    21241 gccaccccat agtggtcggt ggctccttgc gtgatgcttg gcgcgaagcg gcacctgaaa
    21301 cctcctggga cggggacgcg cacgtcggcg cgggtccggg tgtcgaggcg gatcaccgcg
    21361 gtgttcctgg caccgccacc gttcgacgtg cgttcggcca ggtacagggc gcccggtacg
    21421 gaagccgcga agtcgagaat cccgttcttg gtcgtggtcc acgctgtgtg cccggttgcc
    21481 ggctcgatgg ctgtgattgc ggtgcgcttg gggtgttgac cgcgcttcgt cagtgtctgg
    21541 agggcgtaca gtccgtcgga cgtggcggcg agtacctcgt ctgtacggag aggccgtttc
    21601 caccgggtgc tgcgggtggc cacgttgacc gccacgatct cgtttttgac cgggtccgtg
    21661 atgtacaggg tctgtctcac cctcaccaac tgcgcgacct ggaatagggg gacctccgga
    21721 aatgcgatgt cgggaaggag acgggtccat agcgtccgac cggtgtcggc atccagcgcg
    21781 tagatccggg agcgcagtgg ttcctgtccg tcgtcgggta actcgcgggc acgctctcgg
    21841 acgatgaaca ccatgccgcg ggcgacgcca agtacgaccg tgccgcccct tggggatgtg
    21901 aagttggcgt accggtcagc gggcgctgca ctcgtccagg cgatgcggcc gtcgtcaaac
    21961 gtattgatgc gggcgacgga gccattgcca gtgacacagt agatgacttc gtcatatgcg
    22021 gtacaccgct ggatgccgcc gttccccgtg aggcgtgcct cccacgggcg ccagccctcc
    22081 tcggcggacc tggtcgtcgg cgaggaggct ggagttgacg gccagagggc caccgtaccg
    22141 atccctgttg ccgcggatgc caggactgta agggtcatca gccaagcggg cacccgttga
    22201 ttcagccagc gggtcgtgat gatacgcagc gtgtgaaccg ctgcatgacg ggctgttgtt
    22261 cgctttggtt cggaggaaac cagggccaac agcagatctt caggggtggg ccgttcggcc
    22321 ggaggcttcc gcaggcagtc cgcgaccagg tcgtgcaagg actcgggcag agcactgagg
    22381 tcgggcttct cgtgcctgct caggtgagct gatgcgtagg cgctgccggc gtcgaaggga
    22441 ctgcgtccgg tcgcggcgaa aacgagcacg caccccagag agaacacatc ggccgccggt
    22501 ccggcttcag agggcgtggt gaactgttcg ggtgccatga aggcgggggt gccgacaatc
    22561 tggccggcgg cggtgagggg tcttccgtcg acggctcggg agacgccgaa gtcgatgatc
    22621 agcgggccgc gctcgctcag cagcacgttg ccgggtttga ggtcgcgatg caccaccccc
    22681 gcccggtgga tgtctcccag agcaccggcc aacgcccagg ccagcgcgcg gagttccggc
    22741 tcgtcgagtg gtccatgctc ccgtacacgg gcagcgaggg actgtcccgg gatgtagcgg
    22801 ctggccatcc acgggtccgt tgcgtatgga tcggcgtcga tgatcggcac cgtgtgcttg
    22861 ctgtggacca tgcgggcggc ggcaacctcc agctggaagc gggcccggaa ctccgggctc
    22921 tcggcccact gacggcgtat caccttcagc gcgacgacct gaccggacgc ggagcatgcc
    22981 cggtacacca cccccatgcc ccccgacccg agccggctct ccaagcggta cctgcccacc
    23041 caggtgggat cgtccttcag cagcgtcacc caagccccct tgcacacggc ccttgcccga
    23101 gacagcgagt gagcgtagag cccccggatg gccgtcggtg gcgtgttgcg cggatcagtc
    23161 gcagcgaaac gtcactgctc tgcgacagtc ggatgaatgg cgaacagcgt ttcgaaactt
    23221 ggcggcgaag gccgtagctg agggccgcgg tgagtggggc ggggccgaaa accgagtcgg
    23281 gacgcattcc gcgcggacgc ccagggactc ccgctcctaa gtcggcgaac cagatcacct
    23341 gagaccacga gcaaaacgga ccggatcacc tgagacgggg actaaatcct cggagacggg
    23401 gcaggagttg ctcgactcac ttcgctatcc aaggacatca attgtccttc ggcaacgaag
    23461 ttagtcgtgc gcagccagct gacttgggcc gactaggttg gatgtcaacg agtctgctcg
    23521 tactgacggt gactgggaag gtgcccctga tctcgttgag ggtgtccccg tgctgtccga
    23581 gatcgtttcc cggctcccgg tgtcctgccg cgccggacct tgagccgaac agcgcaggca
    23641 aggcagagcg gtagccaaga tccgtcttct ccggcgctgg tggttagtgc cgacgctacg
    23701 tcacctcaga ctgccgagtc gtcagcaggg ggccatgacg gatgccttgg ccatgtagca
    23761 gtccccctga tcggcaacgg cgccgaagct ggacatggac cgcatgccag tcccgacctc
    23821 tatgctcagc tcgtgactga cttgcttgcc agcaacgacg gcccatctga agggcaacac
    23881 cacgacctcc acgacttcat ggaggaaact gcaacagagt tggcgaggga atacacgcgg
    23941 atcacacgca gatcgaagga ggatccggga acagcgggcg atgaggctga gagcaattgg
    24001 caggagatcc ttaagggcta tctcccgcca tctctcccag tggtcaccaa gggacgcatc
    24061 ctcggcgtgg acggtcgctc cagccctcaa gttgatgtgc tggtgcttag ccccaactac
    24121 ccgaagcgac ttttggggag gaagcaatac ctggcatctg gcgttttggc tgccttcgag
    24181 tgcaaactca cgcttcgcca acgagacctc tctaagatcg gtgaaaatgc ccggctcata
    24241 cgtgatctcg cacccgagaa cgagccgtcc gtatatggaa accttcattc atcgatcatt
    24301 tacggggtcc tcgcccacag tagtgagtgg tcgtcgcatg ccgatccgga gggcccggac
    24361 tatgaatttc ggctcgaccc tcttagggac tggccgacac ccctggatgg ggccctgaaa
    24421 aggctcatgg accgcgcagc tcaccctcgg gacctgttgg acgtgctatg catcgccgac
    24481 ctggcctgct acgaaaggga cacgcgagta attccaggga aggagtattt ctctcctggt
    24541 gactgggcgc gactgaaagc gaatcatcaa atctccgacg aaggtgaagt atcgactagt
    24601 tatttccgcc ccgcaaggtt ccacagcctt ggaaatgcga cggaaagcgc gctgttcagc
    24661 ttcatcgtaa agatccttta tggtatttcc tggaagattc cgagctgtca ggcgatggcg
    24721 gaatattggc gcctatccca gaacgaggaa gtccgcgagc tccgctgtgg tcctagtcgt
    24781 tcatggccgc tgtccgtcct gtcggagcac gtactcgcca aaatagaggc gggctccctt
    24841 gagcaagggc actgctggtg cgggtggggc tccaagttcg agtagccgac tgggcgtgaa
    24901 gggctaacgg ctgagttcac tgtcaaacgc ctcgattgaa tggcagagga catcagttcg
    24961 ccccaggcag acataaaaga tcctgaaagg gctggtgcct ggcgccagtg gcatgtcaac
    25021 ctgcaacacc tcgccagagg ccacaggctt gatggtcgac gtctgtgacc tcatacgacg
    25081 cctctctgcc tacgacctgt agccattccc ctcgatggtg actgatccat ctccgagctc
    25141 atggaggcgc ccctgaactc gcaccacccc agcgacccct cccgtcccga ctcgccagac
    25201 cccgttgtac tgggtcacgc cgcgccactt ggccggtgac gatcgcgcgc ttgccgagcg
    25261 gatcggcgac accctggtcg gcctcggctg gcggatgtgg cccaccgccc gcagcaccct
    25321 gctgtacgtg agcccagacg ggctgtgcgg cgccg
//
