LOCUS       NZ_CP080647            21387 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces akebiae strain MG28 chromosome, complete genome.
ACCESSION   NZ_CP080647
VERSION     NZ_CP080647.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces akebiae
  ORGANISM  Streptomyces akebiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10257202)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2021) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019599145.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:26:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,127
            CDSs (total)                      :: 9,036
            Genes (coding)                    :: 8,727
            CDSs (with protein)               :: 8,727
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 142 of 309
            Pseudo Genes (incomplete)         :: 231 of 309
            Pseudo Genes (internal stop)      :: 20 of 309
            Pseudo Genes (multiple problems)  :: 77 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4512166
            Orig. end                         :: 4533553
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP080647.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21387
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="16"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21387
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21387
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11387](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11387
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            150..572
                     /locus_tag="K1J60_RS19355"
                     /old_locus_tag="K1J60_19355"
     CDS             150..572
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS19355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_19355"
                     /product="hypothetical protein"
                     /protein_id="WP_220647297.1"
                     /transl_table=11
                     /translation="MEAIPGSAVVTITEHSVPGRAQGIAAGPEDNVWFTQPQDVQIGRI
                     TPAGVVTEDDVPVGNSTSVGIAAGADGNLWFTHFSTNKIGKATTSSFVDEVSETVQLAR
                     TSRRFFDPPDRDQAVEDVDDKLGRGAWLRTRLVSRR"
     gene            complement(625..918)
                     /locus_tag="K1J60_RS19360"
                     /old_locus_tag="K1J60_19360"
     CDS             complement(625..918)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987675.1"
                     /locus_tag="K1J60_RS19360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19360"
                     /product="DUF1330 domain-containing protein"
                     /protein_id="WP_220647298.1"
                     /transl_table=11
                     /translation="MAKGYWVSVYPAISDPERLTDYNELAGLAVRAGGGRVLSNFGRVV
                     AHEAGITERVVLIEFDGFEQAVAAYESEAYQKALVALPDGFERDFRIVEGID"
     gene            1104..2006
                     /locus_tag="K1J60_RS19365"
                     /old_locus_tag="K1J60_19365"
     CDS             1104..2006
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548576.1"
                     /locus_tag="K1J60_RS19365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19365"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_220647299.1"
                     /transl_table=11
                     /translation="MAPDTVSLRYFLVLAQELNFTRAAARIGIAQPALSARMRRLEAEL
                     GTALLVRNTRSVVLTTAGAALAESAPPALAALDRAWDTARSAAAGELGTLRIGYSLSAG
                     AETAPALVDRLIRGNSGLEVGAVPMATPEISPAVADGRIDAGITRGEQPGRGVRRFLLR
                     RMRVGVQLAQHHPLAEHPEIEIADAAAYPLRLPDRAANPVIHDQLSALFRDTRPHPRFH
                     TPAVSFDMSQRDLRDGVTLAPAGEAAATAQPAGLTWRPLRGAPSLTIHLVLPREQSPLH
                     RRIRAVAKTLAHELHWLPD"
     misc_feature    2342..2360
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.32"
                     /tool="antismash"
     gene            2620..3443
                     /locus_tag="K1J60_RS19370"
                     /old_locus_tag="K1J60_19370"
                     /pseudo=""
     CDS             2620..3443
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574917.1"
                     /locus_tag="K1J60_RS19370"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19370"
                     /product="PIG-L family deacetylase"
                     /pseudo=""
                     /sec_met_domain="PIG-L (E-value: 3.6e-28, bitscore: 97.9,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGG
                     CGDGPGGVKPGDPGHDPAAVASLRRQELKASCDVLKVSDLEMLDYADSGMTGWPSNDAP
                     GSFWGTPVAEGAARLAELMRHYRPDVVVTYDENGFYGHPDHIQAHRITMAALEMTALAP
                     KVYWTTMPRSMMQRFGEIMREFHPDMPEPRPPRWPRSASPTMRSPRGWTPPRSAARSST
                     CWPRTPVRARTSSSSRWARSGSAS"
     gene            3607..5376
                     /locus_tag="K1J60_RS19375"
                     /old_locus_tag="K1J60_19375"
     CDS             3607..5376
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354741.1"
                     /locus_tag="K1J60_RS19375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19375"
                     /product="hypothetical protein"
                     /protein_id="WP_220647300.1"
                     /transl_table=11
                     /translation="MQDPSDSTEIAEPDENGRGNTADSPVVDDPTSDSDIDSTTASTVL
                     VEVLPGVAVVAGEVPPELKPDLIDFGIVPAADRKQISAILASIGNAATVVGNLGNAFAS
                     VQGLYRIGDTAQALLKSGATLAAKDGGNLGAVMVPGRILHQARFYSVNAVSKAQTAASI
                     GPALAMVGLQMMLSEVSGLVRTNLAVTSQVLTTIRKDQWAELTGLVAAIDRAVDQAREI
                     ESVPTSLWEDVAGSGALLQKQLELYQGNVRDHVRQIGRADARSHREYLQTNAEAIAFDA
                     YALLSSLKAWTGYHALRAARARAAGREDAAEAQYAEVIARDTRAEFDSALAESTSLVDA
                     LTRELRITAELPGPDAWPLPGKRKDVKAARETSARLLEAVEPLADALHPPAPPLKAPGV
                     VCTPKSLDLKPYLRILRWLLEDGEALRVLGFPDQLDALGPISAIVGGAKEKLAAARDKA
                     AAKTLVAVTDRRIITAKTNAFLEQAEIRQDIPIDQVRYVRATTTQDRSARLAIDLITRD
                     ENIRWLFHADVDNTQVDALAAVLAESMTIPDAERDELQRRRYAPIEAGKKSESTGTRST
                     KPTGSEATTRDAE"
     misc_feature    5565..5576
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            5565..6413
                     /locus_tag="K1J60_RS19380"
                     /old_locus_tag="K1J60_19380"
     CDS             5565..6413
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058979.1"
                     /locus_tag="K1J60_RS19380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19380"
                     /product="IS5 family transposase"
                     /protein_id="WP_220647301.1"
                     /transl_table=11
                     /translation="MSERKPYPSDLSDEQWSLIEPVITAWKDRHRSVSGHQGAYDMREI
                     VNAILYQGRTGCQWAYLPHDLPQKSATYYYFAAWRDDGTDQVIHELLRCQVRERARRLE
                     DPTLVVLDTQSVHVAAGVPAATSGHDPAKRVPGRKRGLAVDVLGLVIAVVVLAANTHDN
                     TAGIILLNQVAQHAGGTVRKALVDQGFKNQVVLHGAGLGIDVEIVARNPQDKGFVPQPK
                     RWRVEQTYGILILHRRLVRDYEHRPSSSASRVYWAMTHVMTRRLTGANAPTWRTAQAVA
                     A"
     misc_feature    5595..5597
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5871..5873
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6410..6808
                     /locus_tag="K1J60_RS19385"
                     /old_locus_tag="K1J60_19385"
     CDS             6410..6808
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131781.1"
                     /locus_tag="K1J60_RS19385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19385"
                     /product="hypothetical protein"
                     /protein_id="WP_220647302.1"
                     /transl_table=11
                     /translation="MNIRPLLDALDLQEDAARALADDLRAQIDDLQTRWREAETHLEHL
                     TITRKTVTGLADRLPTVAPDLPEHPDYPRILAAFNHTTGPLRAKDVCEALGHELQPKNV
                     EGTRAKLKRLVKLGILTEADTGNFARTQ"
     gene            7105..9873
                     /gene="haaT"
                     /locus_tag="K1J60_RS19390"
                     /old_locus_tag="K1J60_19390"
     CDS             7105..9873
                     /codon_start=1
                     /gene="haaT"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238995.1"
                     /locus_tag="K1J60_RS19390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19390"
                     /product="cyclophane-containing RiPP biosynthesis TPR
                     protein HaaT"
                     /protein_id="WP_220647303.1"
                     /transl_table=11
                     /translation="MRLRRGIAIAVVAGGCALTTMLVGLVTNAVSDESRWPGWLGWLQE
                     HAWFSFVVLGVTMAGLTALLAGLSETRPPTPPGRPEDGTGPPGAAQVLRSLPRDTAAFT
                     DRAAELERLVGSVRASQERGEGLPVHVIDGMPGVGKTTFAVHAGHLLSERFPDGQLFVN
                     LNGHTPGRTPVQAGEALASLLAAAGVPTQQIPVGDDVGAVTEARAAMWRSRFADKKALL
                     ILDNAASYRQLEPLLPGGSGCLVLVTSRKRLVANEEVVMSVDALPPDHAVDLFVRLSGR
                     PADTFDRDVVDALVRLCGCLPLGVSLLAARLRHHPSWNAEDLRGRLVAARDRLGELRAG
                     ERAVTATFDLSYRDLAPERQRFFRRLGLFPGTDLDPHVGAALGDVSVVVARLHLEALYD
                     DHLIDEQPGSRYRLHDLLRDYARGLAAEGDSMDHAQAVQRVCAYYLAALTVVNGHIGRS
                     GAVVPPAPDGASRVETPPLESRADALSWLETERANILACVRRANGLALYDLVVRLAAAM
                     APFLRQAGPWDQAVGLHRTAAEAARHTGDQRARGDALAELGVVRRFMASYPQAIEALNN
                     AVTAYEAVDDRRGKADTLNQLGIVWYLTADNEDAARAQTDALALYRELGNRLGQANALA
                     DLGMTHRQMSRFDTAVEAQSEALAIYRELGDRYGEANSLRDLGVVHCLMGAYDLAARHH
                     REAFDIYLELDDRVHQAYALNELGVVRRLTGDMEGARTAHSQALTHFTELGERFGRATS
                     VRQLGVVERVTGDATEAIRLLVEALDVYRELGSRGGEAASLSELGVARGIVGERDGAIE
                     AFQRGLQILRGLGDRCGEAEVLNHWGMLLFTSGESAAARGHFDQALTLARDIRCPLEEA
                     RALEGIGRCDWTIDGPGHGVGSLRAAVTVYRRLGVSAAVNDIERLLVSRSG"
     misc_feature    7231..7233
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8206..8208
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..10204
                     /gene="haaA"
                     /locus_tag="K1J60_RS19395"
                     /old_locus_tag="K1J60_19395"
     CDS             10001..10204
                     /codon_start=1
                     /gene="haaA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061149.1"
                     /locus_tag="K1J60_RS19395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19395"
                     /product="HaaA family cyclophane-containing RiPP peptide"
                     /protein_id="WP_220652000.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPPASVTEPCTITPVGPASVEPTASGTAVLDRVAARVRQRLEAE
                     EGATGPVGAGAHAASLIWPWPL"
     gene            10218..11387
                     /locus_tag="K1J60_RS19400"
                     /old_locus_tag="K1J60_19400"
     CDS             10218..11387
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061150.1"
                     /locus_tag="K1J60_RS19400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19400"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_220647304.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.2e-74, bitscore:
                     249.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 4.6e-125,
                     bitscore: 416.3, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.7e-10, bitscore: 40.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.2e-07, bitscore: 31.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPEEPEGPVPFQTFILKVANRCNIDCDYCFVFNSKDQAARRLP
                     ARMDLAVARAAARRIGEHASAHRLRTVHVVLHGGEPLLIGVGHMAGLLEAVRDAAPAGT
                     RVLFELQTNGTLLSDAWLDLFERYEVAVGVSLDGPPRANDRHRLTHAGRSSAASAMRGI
                     ELLRSRPHLFAGLLAVVDLANDPVEVHDYLAAFEPPVVDFGLPHATHDDPPHRADPSVP
                     EYGLWMSRVYDAWLARPEYGHSVRMLEDIVALSSGVRGSVETLGLAPPTSVVIESDGSI
                     EAVDTLRSVEEGATWLGLDVLRHSFDEALSHPKLLHRQHGKDALAEQCRACPLVDVCGG
                     GYLPHRFSEAQGYRNPSVYCTDLEYLIRHVQSSLRQHGWNPYAQAASPP"
     gene            11480..11959
                     /gene="haaN"
                     /locus_tag="K1J60_RS19405"
                     /old_locus_tag="K1J60_19405"
     CDS             11480..11959
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene="haaN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142306.1"
                     /locus_tag="K1J60_RS19405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19405"
                     /product="cyclophane-containing RiPP N-acetyltransferase
                     HaaN"
                     /protein_id="WP_220647305.1"
                     /transl_table=11
                     /translation="MTVTIRPAEKRDVPAVAGLIEEIERFYGAADTDIQPIEERRLQVE
                     EALFGVPPLASALLVEDETGDIVGLAAYSFLWPATGSSHSLFLKELYVRDTLRRQGIGA
                     RLMDELRALAAARPGCSRVEWMTDRDNPGARAFYESRGFTESDGKIVYRVDSGTA"
     gene            complement(12430..13263)
                     /locus_tag="K1J60_RS19410"
                     /old_locus_tag="K1J60_19410"
     CDS             complement(12430..13263)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.5"
                     /locus_tag="K1J60_RS19410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19410"
                     /product="hypothetical protein"
                     /protein_id="WP_259407794.1"
                     /sec_met_domain="PCMT (E-value: 6.8e-14, bitscore: 51.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGVTPELDANGCDDVRVVTRDGALGAEEFSPYDRMIAAVGMWDL
                     PGTWWDQLAVGGRLVVPLRWRGLSRSVAFRREKDRMTSDSVKMCGFLPVIGQDGERNDY
                     IDDDRFVRLYWDEDQPIVPELLRDALTRPKTVVWTDATVGPVESFDGVWLRLSATERAT
                     CRITANPAAMEAGLHRPASPALSPALVEGDSIAYFTLERTAADPGTEPRFRLGAVGYGP
                     AGADLAERICAQIRAWSPARTVEPAVTAYPADTPDNDLADGAVIDRPSVRLVITY"
     gene            complement(13380..13790)
                     /locus_tag="K1J60_RS45920"
     CDS             complement(13380..13790)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS45920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_259407795.1"
                     /transl_table=11
                     /translation="MHTSEPSSTSCLPWACSALLGVAMGCAAWSLTVWARAYCDAGYDA
                     GGRLELNFLLTLVVGAEALVGLVALAIGRRLTLRAPRALRAALPTLLVVVATVGPAWWL
                     FATRGTLDGYPGDSGLCPTSNVPPQWPAWLPA"
     gene            complement(13853..15019)
                     /locus_tag="K1J60_RS19420"
                     /old_locus_tag="K1J60_19420"
     CDS             complement(13853..15019)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018516219.1"
                     /locus_tag="K1J60_RS19420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19420"
                     /product="cytochrome P450"
                     /protein_id="WP_220651552.1"
                     /sec_met_domain="p450 (E-value: 3.5e-25, bitscore: 87.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDPAFFADPYPTYARLREAAPVRRVPTGSGGRHSYLVTGYTEAR
                     EAFTDPRLSKDTTKFFAGRPSQRDLHPAVSRNMLATDPPHHARLRALVTKAFTTGAVAR
                     LRPYISGLVDELLDAWPDHGTVDLVADLAVPLPVTVICELLGVPESDRASVRTWSSDLF
                     AAGDPRRIDAASHAVGDYMTALVATKRTAPGTSLLDDLIAVRDGQDRLSEDELVSLAVL
                     LLVAGHETTTNFIGNAALALLRHPESLARLRAEPQLLGSALDELLRYDSPVGIATFRYS
                     TEALTLGGTEIPEGAPVLIAPGAANRDPDRFPDPDRLDLTRPAAGHLAFGHGIHRCLGA
                     PLARAEAELALHAVITRHPHASLAAPVETLPWRHTRLTRGLKTLPLTL"
     gene            complement(15127..16410)
                     /locus_tag="K1J60_RS19425"
                     /old_locus_tag="K1J60_19425"
     CDS             complement(15127..16410)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018516218.1"
                     /locus_tag="K1J60_RS19425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19425"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_220647306.1"
                     /transl_table=11
                     /translation="MIDLLFAGVALVLLLAAGYWVRGRGGHRPTGTWAMAALLVSFACA
                     FGSYVSVVENAVESVVPDGGRLLSNSFTLTAATSVLAFMLQLDQEPDEARRNIRRRVLF
                     LGISVTAMTVLFTASQLNDDSPQLYALYVLIYVTYLSVTAKDFGTQTWKQAGHSRRKSQ
                     RVGLRITSVGCVFALLYAAYKVFGLVSIGLELDLLPHGVRCSTPISPVRCVFSVTAPAV
                     AVLLVTVGLTLPAVVWPFSQFLRRRWESRSFAALAPLWKDITDTTPEVVLGPAGSQHVD
                     DSDFHLHRRVIEINDGVLALRPHRSVRVQESAERAVAARGLTGTQEGDAIVEAAILRAA
                     VHAKTTGSEPRTGSEPRTGSEPRTGSEPRTGNELRTGAAPAPSRTASRAGNLRAETEWL
                     LLVAQAYTQHETTPTTDPLAPSGTDPRT"
     gene            complement(16407..16895)
                     /locus_tag="K1J60_RS19430"
                     /old_locus_tag="K1J60_19430"
     CDS             complement(16407..16895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018516217.1"
                     /locus_tag="K1J60_RS19430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19430"
                     /product="regulator component"
                     /protein_id="WP_259407796.1"
                     /transl_table=11
                     /translation="MDALRLPHRFNTRDLCDAVAEMRGRPIILRPLSTLGAIDAPCGIR
                     LETPDADLLFYEEGTSALHQNHILAHEVSHIICDHPGTLELDADAFRALGFNPTLVQRM
                     NGRTSYSTDDEREAETMATVIRQHIYRGRELPPREPEKGAERWEALFAKPTRKGRRRR"
     misc_feature    complement(16491..16493)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17416..17871)
                     /locus_tag="K1J60_RS19435"
                     /old_locus_tag="K1J60_19435"
     CDS             complement(17416..17871)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743477.1"
                     /locus_tag="K1J60_RS19435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19435"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_033524580.1"
                     /transl_table=11
                     /translation="MTDDEPRTFAQLLDHLFQEVHPAGRGPYTYAEVAEGIREASGDEG
                     KGLTASAIQQLRTGAKKNPTRHTIKALADFFGVPAGYFVDEQAAHRTRAEIAVLAAMRD
                     QNVRTVALRANGLSAETLQMVTAVIEQARILEGLPGETPSNGLDLDN"
     misc_feature    complement(18824..18838)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(19939..19949)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
ORIGIN
        1 cgtcagcacg agcagaatcg ttgacatcca acctagtcgg cccaggtcag gggactgcac
       61 acgactacag aaccggcacc cggctccgcc ccgccgggtt ctacccgggc cagccgagga
      121 ggaagtgagc gctccgctac aggcgcgggg tggaggcgat cccgggatcc gcggtggtga
      181 ccatcaccga gcacagcgtg cccggccggg ctcagggcat cgccgcgggc ccggaggaca
      241 acgtctggtt cacccagccc caggacgtcc agatcgggag gatcacccct gccggggtgg
      301 tcacggagga cgacgtgccg gtcgggaact ccacgtcggt ggggattgcc gccggtgcgg
      361 acggcaatct gtggttcacc cacttcagca ccaacaagat cggcaaggcc accaccagca
      421 gtttcgtcga cgaggtcagc gagacagtcc agctggcccg gacgtcgcgt cgtttcttcg
      481 atccgcccga cagggatcag gccgtcgagg acgtcgacga caaactggga cgcggggcat
      541 ggcttcgaac tcgtctcgtg agtcgtcgtt gagcaccgtg tgcgtgtcag gtgacggatg
      601 cccagcgatg gctgggcccg ccggtcagtc gatgccttcg acgatgcgga agtcgcgctc
      661 gaagccgtcg gggagggcca ccagcgcctt ctggtatgcc tcgctctcgt atgccgcgac
      721 cgcctgttca aagccgtcga actcgatcag aacgacgcgt tcggtgattc cggcctcgtg
      781 ggcgacgact cgaccgaaat tggacaggac gcgcccgccc ccagcccgga cagccagacc
      841 cgccagctcg ttgtagtcag tcagcctctc aggatcggaa atggcggggt agacactgac
      901 ccagtagccc ttggccatgg aaaacctcct gtgttgggcc ggacacgtcc gacttcgaat
      961 tgacactcag atcgatcccg gcgacgggca ccgcggtcag ttgcatcgcc atatgcgcag
     1021 gttagggctt gatctgaggc caagggaaag accggttcgg gataggctca gaacggatcc
     1081 ttatcaatcg gcagggaggg cacgtggcgc cggatacggt gagcctgcgg tacttcctgg
     1141 tgctggcgca ggagttgaac ttcacccgcg cggccgcacg gatcggtatc gcgcagcccg
     1201 cactcagtgc ccggatgcgc cgattggagg cggaactcgg tacggccctg ctggtccgca
     1261 acacgcgtag cgtcgtattg accacggccg gtgcggcttt ggcggagtcc gcgccgcccg
     1321 cgctggcggc gctggaccgg gcatgggaca ccgcccggag cgcggcggcc ggtgaactgg
     1381 gcacgctgcg catcggatac agcctcagcg ccggggccga gacggcaccg gccctggtgg
     1441 acaggctgat tcgcggcaac agcggactcg aggtcggcgc ggtcccgatg gcgacaccgg
     1501 agatctcccc cgcggtcgcc gacggccgca tcgatgccgg gatcacccgc ggtgaacagc
     1561 cgggccgtgg cgtgcgccgg ttcctgctgc ggcgtatgcg cgtcggagtc cagctggcgc
     1621 agcaccatcc gctggccgaa cacccggaga tcgagatcgc cgacgcggcc gcgtatccgc
     1681 tgcggctccc ggaccgtgcg gccaaccccg tgatccacga tcagctgtcc gcactgttca
     1741 gagacacccg accacacccc cgattccaca cgcccgcagt ctctttcgac atgtctcagc
     1801 gcgacctgcg cgacggggtc accctcgccc cagccggaga agccgcggcc acggcacaac
     1861 cggccggtct cacctggcga ccactgcgag gcgcgcccag cctgacgatc cacctggtcc
     1921 tcccacgcga gcagtcgccg ctacaccgcc gcatccgtgc cgtcgccaaa accctggcgc
     1981 acgagctgca ctggctgccg gactgacgcg caagaggtca agcgagacgg acgcctgcgg
     2041 tggcgaggcc gaagaccttg cgcccggcgg acttcgcggt gatgacgacg acggcggtct
     2101 tgctgaatgt ccgacacgac ctcgctacgc cggcggatca gtttccgatg atggcccggg
     2161 ggccggtccg agtcgtacac cgcggcgacg tcctcgccca gcccgagatc tcggcggata
     2221 ccgcgccttc gccgacgccg aaccggacaa gcacgggtaa ccggggaatc gttgacatcc
     2281 aacctagtcg gcccaggtca gggggctgca cacgactaac ttcgatgtca aaggacagaa
     2341 ctggtggata gatggacagg tagggtctcc agtttcgcgt cggaatctca cgcctggtgc
     2401 cggatggaag tcggatccga cctggcgctg agaggtgcag ccgcgccggg aacagcgggt
     2461 ccggccggca ctgttgcatc gaccgggggg gccggcgctg cacgggcggg gaactcggag
     2521 accacaaggt cgtctgcccc gacaggatcc gggccccggg atcgcggtac gcccgccgca
     2581 cactcggacc aagacgtatt tctgcaggag gactgcttga tgactgaccg gcccttgacg
     2641 ctcatggcgg tgcacgccca ccccgacgac gaggccacgg gaaccggagg ggtcctcgcg
     2701 cggtacgcgg cggaaggcat ccgcacggtt ctcgtgacgt gtaccgacgg cggttgcggt
     2761 gacggaccgg ggggtgtcaa gcctggcgat cccgggcacg atccggcggc cgtcgcatcg
     2821 ctgcgccgtc aagagctcaa ggcgagctgt gacgtcctga aggtcagcga tctggagatg
     2881 ctggactatg ccgactccgg gatgacgggc tggccgagca acgacgcccc cggatccttc
     2941 tggggaaccc ccgtggcgga aggcgcggcc cgactcgcgg aactcatgcg gcactaccga
     3001 cctgatgtgg tcgtcaccta cgacgagaac ggcttctacg gccaccccga ccacatccag
     3061 gcccaccgca tcacgatggc ggcgctggag atgaccgcgc tggcaccgaa ggtgtactgg
     3121 accacgatgc cccgctcgat gatgcagcgg ttcggcgaga tcatgcgcga gtttcatccg
     3181 gacatgccgg agccgaggcc gccgcgatgg ccgagatcgg cctccccgac gatgagatca
     3241 ccacgtgggt ggacaccacc gcgttcagcg gccagaagtt cgacgtgctg gccgcgcacg
     3301 ccagtcaggg cgagaacatc ttcttcctca agatgggcaa ggagcggttc ggcgagttga
     3361 tgggcatgga gaccttcgta cgtgtccagg acgccaccgg cgcggccgta cccgagaacg
     3421 atctcttcgc cggactgcgc tgatccactc atccggagcg gagccctggg gagctcagct
     3481 ggcaccagcc agtgcggaat cagcccggcg gattcgggct gaaccgcagg gcgttgagcc
     3541 gtagaattcg gcagtcaacg ccgacgaggt ccggccgttg cgcgcgcttt cgggggagga
     3601 gatcgcatgc aggacccttc ggactcgacg gagatcgccg agcctgacga gaacggccgg
     3661 ggcaataccg ccgactcacc tgttgtggac gatccgacgt ccgactcgga catcgactcg
     3721 acgacggcgt cgacggtcct ggtggaggtg cttccagggg tggctgtcgt cgccggtgag
     3781 gtcccgccgg agctgaagcc cgatctgatc gacttcggga tcgtgccggc tgccgaccgc
     3841 aagcagatct cagcgatcct cgcctcgatc gggaacgcgg cgaccgtggt cggcaatctc
     3901 ggaaacgcgt tcgccagcgt gcaggggctc tacaggatcg gcgacacggc acaggccctg
     3961 ctgaagagcg gcgcgacgct cgccgccaag gacggcggga acctcggagc ggtgatggtt
     4021 cctggccgca tcctgcatca ggcccgcttc tactccgtga atgcggtgag caaggcgcag
     4081 accgcggcct cgatcgggcc ggcgctggcc atggtcggcc ttcagatgat gctgagtgag
     4141 gtctcgggcc tcgtgaggac caacctcgcg gtgacaagtc aagtcctcac caccatccgc
     4201 aaggatcagt gggccgagct gacggggctc gtcgccgcca tcgatcgcgc cgtcgaccag
     4261 gcgcgagaga tcgaatcggt cccgacgtcc ttgtgggagg acgtcgcggg cagtggagcg
     4321 ctgctgcaga agcagcttga gctctaccag gggaacgtcc gcgaccacgt caggcagatc
     4381 ggtcgggccg acgcacgcag ccaccgtgag tatctgcaga cgaacgccga ggcgatcgcc
     4441 ttcgatgcct acgccctcct gtcctccctc aaggcatgga ccgggtatca cgcgctccgc
     4501 gccgcaaggg cgagagccgc tggacgcgaa gacgccgccg aggcgcagta cgccgaggtc
     4561 atcgcgcgcg acacccgcgc ggagttcgac tccgctctcg ccgagtcgac gagcctcgtc
     4621 gacgcgctga cgcgggagct gcggatcacc gccgagctcc ccggacccga cgcatggccg
     4681 ctgccgggga agcggaagga cgtgaaggca gcccgcgaaa cctccgcccg tcttctggag
     4741 gcggtcgagc ctcttgccga cgctctccat ccgccggccc ctccgctcaa ggctccgggc
     4801 gtcgtctgta cacccaaatc gctggatctc aagccgtacc ttcgcatcct gcgatggcta
     4861 ctcgaggacg gtgaggctct acgtgtcctc ggcttccccg accagctcga tgccctcggt
     4921 cccatttctg cgatcgtcgg cggagcgaag gagaaattgg cggcagcgag ggacaaggct
     4981 gcggcaaaga cactggtcgc cgtcacagat cgccgcatca tcacggccaa gacgaacgca
     5041 ttccttgagc aagccgagat ccggcaagac atcccgattg accaagtgcg atacgtccga
     5101 gcaacgacca cacaggacag aagcgcgcgc ttggcgatcg acctcatcac gcgcgacgag
     5161 aacatccggt ggctcttcca cgctgacgtg gacaacactc aagtggacgc gctcgccgcc
     5221 gtgcttgccg agtcgatgac gatcccggac gctgaacgcg atgagctgca acggcggcgc
     5281 tacgccccta tcgaggcggg caagaagagc gagagtactg gcacgaggtc tacgaaaccg
     5341 actggatccg aggccacgac ccgcgatgcc gagtaggccc cgagccgatt gagcaggtcg
     5401 tggccggggc cgatagggaa gcagccaccg cgtgatcatc agaggttgcg tggagttctg
     5461 agtgggcggt tcgtgagctt ttgggttgat ctggtgtcgc ctgatggtgt ggtggcgggg
     5521 cggaacccgc cggtccgcgg ctattgatct gttgatgtga tcgggtgagt gaacgcaagc
     5581 cgtatccgag tgacttatcg gacgagcagt ggtcgttgat cgagccggtg atcaccgcgt
     5641 ggaaggaccg gcaccgctct gtcagcggcc accagggcgc ctacgacatg cgggagatcg
     5701 tgaacgcgat cctctaccag gggcggaccg gttgccagtg ggcctatctc ccgcacgacc
     5761 tgccgcagaa gagcgcgacg tactactact tcgccgcgtg gcgggacgac gggaccgacc
     5821 aggtcatcca tgaactgctg cgctgccagg tccgggagcg cgcccggcga ttagaggacc
     5881 cgaccctggt ggtcctggac acccagagtg tccatgtggc cgccggggtc cccgccgcca
     5941 cgagcggcca cgatccggcc aagcgggtgc cgggccgcaa acgcggcctg gccgtggacg
     6001 tcctcggcct ggtcatcgct gtcgtcgtcc tcgccgcgaa cacccacgac aacaccgcgg
     6061 gcatcatcct gctgaaccag gtcgcccagc acgccggcgg aaccgtccgc aaagccctgg
     6121 tcgaccaggg cttcaagaac caggtcgtcc tgcacggcgc cggcctgggg atcgacgtcg
     6181 agatcgtcgc acgcaacccg caggacaagg ggttcgtgcc acagccgaag cggtggaggg
     6241 tcgagcagac ctacgggatc ctgatactgc accggcgcct ggtccgcgac tacgagcacc
     6301 gcccctcctc ctccgcctcc cgcgtctact gggcgatgac ccacgtcatg acccgacgcc
     6361 tcaccggcgc gaacgccccc acctggcgca cggcacaggc ggtggcagcg tgaacatccg
     6421 gcccctgctc gatgccctgg acctccagga agacgccgcc cgcgccctgg ccgacgacct
     6481 ccgcgcacag atcgacgacc tgcagacccg gtggcgggag gccgagacgc acctggaaca
     6541 cctcacgatc acccgcaaga ccgtcaccgg cctcgccgac cggctcccaa ccgtcgcgcc
     6601 ggacctgccc gagcacccgg actacccccg catcctcgcc gccttcaacc acacgaccgg
     6661 gccgctacgg gccaaggacg tctgcgaagc cctcggccac gaactgcaac cgaagaacgt
     6721 cgaaggcacc cgcgccaagc tgaaacgcct ggtcaaactc gggatcctca ccgaggccga
     6781 caccggcaac ttcgccagga cgcaatagcc ggcagaacct ccaccagcgt ccttgctccc
     6841 acctcagcaa gaaacagaca tcaccttacg aaccgcccac tgaagatggt gcggtggccg
     6901 tgggccagcg cgccttgcgg cagctggtgc acgccgtggc tcagaggcgc ccttgaccaa
     6961 ggtctacgag gactgttcgg ttagggaagt tggggtgtcg tactcggggg ttgccttcgt
     7021 gaccaggtcg gttggcagtg cgtggtgtct catcagcggc accagggggg aatcggccgc
     7081 tccctcggct gctggggcct ccgtatgaga ctccggcgcg ggatcgcgat cgccgtcgtc
     7141 gccggaggct gcgctttgac caccatgctg gtcgggctcg tcacgaacgc cgtgtccgat
     7201 gagtcgcggt ggcccggctg gcttgggtgg ttacaggagc acgcctggtt ctcgttcgtc
     7261 gtgctgggtg tgacgatggc ggggctgacg gccctgctcg ccggactctc cgagacgcgg
     7321 cctcccaccc cgccggggcg accggaggat ggaacggggc cgccgggggc cgcccaggtg
     7381 ctgcgttcgt tgccacgcga caccgccgcg ttcaccgacc gtgccgcgga gctggagcgg
     7441 ctggtgggct cggtgcgggc ctcacaggag cgcggcgagg gtctgcccgt tcacgtgatc
     7501 gacggcatgc ccggcgtcgg gaagaccacc ttcgccgtgc acgccggcca cctgctctcg
     7561 gagcggttcc ccgacggaca gctcttcgtg aatctcaacg gacacacgcc ggggcgtact
     7621 ccggtacagg ccggcgaggc gctcgcctcg cttctcgcgg ccgccggcgt gccgacgcag
     7681 cagattcccg tcggtgatga cgtcggagcg gtcacggagg cccgggccgc catgtggcgg
     7741 agcaggttcg cggacaagaa ggcgctgctg attctcgaca acgcggccag ttaccggcag
     7801 ctggagccgc tgctccccgg tgggagcggg tgcctggtgt tggtgaccag ccgcaagcgg
     7861 ctggtggcga acgaggaggt ggtcatgtcg gtggacgcac tgccgccgga tcacgctgtc
     7921 gacctcttcg tacggctcag tgggcggccg gccgatacgt tcgaccggga tgtggtggac
     7981 gcgttggtgc ggctgtgcgg gtgtctgcct ctgggggtgt cgcttctcgc ggcacggctg
     8041 cggcaccatc cgtcctggaa cgccgaggac ctgcgcgggc ggctggtggc ggcgcgggac
     8101 cgcctgggag agctgcgcgc cggggagcgc gccgtcaccg cgacgttcga tctctcctat
     8161 cgggatctcg cgccggagcg gcagcgcttc ttccggcggc tcgggttatt ccccggcacc
     8221 gatctcgacc cgcacgtcgg tgcggctctg ggtgacgtct cggtcgtagt ggcccgtctg
     8281 cacctcgagg cgctctacga cgaccacctg atcgacgaac aaccggggag tcgctaccgg
     8341 ctgcacgatc tcctgcggga ctacgctcgc ggtctcgccg ccgaggggga cagcatggac
     8401 cacgcacagg ccgtacagcg tgtgtgcgcc tactacctgg ccgctctcac cgtcgtgaac
     8461 gggcacatcg ggcgcagtgg tgccgtagtg ccaccggcgc cggacggcgc ctcgcgggtg
     8521 gagactccgc ccctggagtc gcgggcggac gccttgagct ggctggagac cgagcgggcc
     8581 aacatcctgg cctgcgtccg gcgggcgaac ggcctcgccc tgtacgacct cgtggtccgg
     8641 ctcgccgcgg ccatggcgcc cttcctgcgc caggccggcc cctgggacca ggccgtcggg
     8701 ctccatcgga ccgccgccga ggccgcccgc cataccggcg accagcgggc ccggggcgac
     8761 gctctcgccg aactcggtgt cgtacgccgc ttcatggcct cctacccaca ggcgatcgag
     8821 gccctgaaca acgccgtgac ggcgtatgaa gcggtcgacg accggcgcgg caaggcggac
     8881 acactcaacc agctcggcat cgtctggtac ctgaccgcgg acaacgagga cgcggcccga
     8941 gcccagaccg acgccctcgc cctctaccgt gagctgggga accggctcgg acaggcgaac
     9001 gcgctcgcgg atctcggcat gacacaccgg cagatgagcc ggttcgacac cgcggtggag
     9061 gcccagagcg aggccctggc gatctaccga gaactcggtg accggtacgg ggaggcgaac
     9121 tccctgcggg acctgggcgt cgtgcactgc ctcatgggcg cgtacgacct ggccgcgcgg
     9181 catcaccggg aagcgttcga catctacctg gagctggacg atcgtgtgca ccaggcgtac
     9241 gcgctgaacg agttgggcgt cgtccgacga ctgaccggag acatggaggg agcgcggacg
     9301 gcacacagcc aggccctgac gcacttcacc gagctcggtg aacggttcgg ccgcgcgacc
     9361 agcgtccgcc agctaggcgt cgtggagcgt gtgaccggag atgcgacaga ggcgatccgg
     9421 cttctggtgg aggccctgga cgtctaccgc gaactcggca gccgcggagg tgaggccgcc
     9481 tcgctgagcg agctgggcgt ggcgcgcggc atcgtcggtg agcgcgacgg cgcgatcgag
     9541 gcgttccaac gcggtttgca gatcctgcgg ggcctgggcg accggtgcgg cgaggcagag
     9601 gtactgaacc actgggggat gctgctgttc acctccggtg aatcggcggc cgctcgcggg
     9661 cacttcgacc aggcgctcac gctagcccgg gacatccgct gcccgctgga ggaggctcgg
     9721 gcgctggagg gcatcggccg atgcgactgg acgattgacg ggcccggtca cggcgtgggc
     9781 tcgctgcgag ccgccgtgac cgtgtaccgg cggttgggag tgagcgcggc cgtgaacgac
     9841 atcgaacggt tgctggtgtc acggtccggt tgacgccgac cacgtggccg aatttcctgt
     9901 gccaggtggg atgttgagga tgctacgttt ccggctgatc tgtcgcttca accccgtcgc
     9961 actgtgccgc ctccggcacg tacctcacga ggagcgttga atgccgccac ccgcgtccgt
    10021 caccgagcca tgcaccatca cgcccgtcgg cccggcgtcc gtggagccga cggcgtccgg
    10081 caccgccgtc ctggaccgcg tggccgcccg cgttcgacag cggctggagg ccgaggaggg
    10141 cgcgacgggc ccggtcggtg ccggtgccca cgcggcctcg ctcatctggc cctggccgct
    10201 gtgagcacgt ccgctcgatg acagaacctg aagaacccga aggccccgta ccttttcaga
    10261 cgttcatcct caaggtcgcc aaccgctgca acatcgactg cgactactgc ttcgtcttca
    10321 actccaagga ccaggcggcg cggcgcctgc ccgcccgaat ggacctcgct gtggcccggg
    10381 ctgcggcccg gcggatcggt gaacacgctt ccgcacaccg ccttcggacc gtccacgtcg
    10441 tactgcacgg cggggagccg cttctcatcg gtgtcgggca catggccggt ctacttgagg
    10501 ccgtccggga cgctgcgccg gccgggaccc gggtcctctt cgagctccag accaacggaa
    10561 ctcttctgtc cgatgcctgg ctggacctct tcgagcggta cgaggtcgcg gtcggcgtca
    10621 gcctcgacgg accgccacgt gcaaatgacc ggcaccggct gacccacgca gggcggtcga
    10681 gcgccgcctc cgccatgcgc ggcatcgaac tcctgcggtc gcggccacac ctgttcgcgg
    10741 ggctgctcgc cgtcgtggac ctggccaacg accccgtgga ggtccacgac tacctggcgg
    10801 cgttcgaacc gcccgtggtc gacttcggcc tgccgcacgc gacccacgac gacccgccgc
    10861 accgcgccga cccgagcgtg cccgagtacg ggctgtggat gagcagggtg tacgacgcct
    10921 ggctcgcccg gcccgagtac gggcacagcg tccggatgct ggaagacatc gtggccctca
    10981 gctctggcgt gcgcggctcg gtggagacgc tcggcctggc cccgccgaca agcgtcgtga
    11041 tcgagtccga cggctccatc gaggccgtgg acaccctgcg gtcggtcgag gagggtgcca
    11101 cctggctcgg gctcgacgtc ctccgccact ctttcgacga agctctgtcg catccgaagc
    11161 tgttgcaccg gcagcacggc aaggacgcgc tcgccgagca gtgccgcgcc tgcccactcg
    11221 tggacgtgtg cggcggtggc tacctcccac accgcttcag cgaagcccag ggctaccgga
    11281 acccgtctgt ctactgcacg gacctggagt acctcatccg acacgtccag agctccctgc
    11341 ggcagcacgg ctggaacccc tacgcgcagg ccgcatcgcc gccgtagacg cgtgccccgt
    11401 accgccagga ggggatcacg cgttggaacg aacgagtgca gcagcgaccg aagcaaccga
    11461 ggaaggacag gaggcgccga tgaccgtgac gatccgtccc gcggagaagc gggacgtccc
    11521 ggccgtggcc gggctgatcg aggagatcga gcggttctac ggggccgccg acacagatat
    11581 ccagccgatc gaggagcgcc gcctccaggt ggaagaagcc ctcttcggcg tgccaccgct
    11641 ggcttccgcc ctgctcgtcg aggacgagac cggggacatc gtgggcctcg ccgcctattc
    11701 cttcctctgg ccggctaccg gctcctcgca ctccctgttc ctgaaggagc tctacgtccg
    11761 cgacaccctg cgtcggcagg gcatcggtgc tcgcctcatg gacgaactcc gcgccctggc
    11821 cgccgcgcgc cccgggtgca gccgggtgga atggatgact gaccgcgaca acccaggcgc
    11881 acgggccttc tacgagtcgc gcgggttcac cgagtccgac gggaagatcg tctaccgggt
    11941 cgactccggc accgcgtgag ggtggtacga gaccagtgaa agaggagcgc tgcgaggagt
    12001 gcggcagcaa gatcgtcatc gggctcggat gcgaatgtcc gccgggctcg tccgcgtcgg
    12061 cgccctcgcg ttcggtaggc acgttcgtga agagggagtg gcgtactcac ccggaggaca
    12121 cgatcctgat ctccccggct cggtgcgcgc acaggcccgg ctggtgcgac cacatgaccg
    12181 aggacgacgt acggccgcca cggtgggggt ggatcacgaa tcctccacct gggctctggg
    12241 agcggttgag tactgcttct ccggcgaccg ccaccgcggg caaccagagc cgacgggccg
    12301 tacggcggtg caccgactgc gagttgaacc ttgcgcaggg ttgaccacag ggctccgacg
    12361 ccgctctgct ctcgtttcgt ctcgtgtcgg tggcgcagcc gcaactgccg acggccgcgc
    12421 ccgccgacgt cagtaggtga tgacgagccg tacggaaggc cggtcgatca cggctccgtc
    12481 ggcgaggtcg ttgtccggtg tgtccgcggg gtaggcggtg actgcgggtt cgacggtcct
    12541 ggccgggctc caggcgcgga tctgcgcgca gatccgctcg gcgagatcgg cgccggccgg
    12601 gccgtagccg acggctccca gccggaaccg gggttcggtg cccgggtctg cggcggtgcg
    12661 ctccagggtg aagtacgcga tggagtcacc ctcgacgagg gcggggctca gggcgggcga
    12721 ggcggggcgg tgaaggccgg cctccatcgc cgcgggattc gcggtgatac ggcaggtcgc
    12781 tcgctcggtg gcactgaggc gcagccatac gccgtcgaag gactcgacgg ggccgaccgt
    12841 cgcgtcggtc cagacgaccg tcttcggtcg ggtgagggcg tcacgcagga gttccgggac
    12901 gatgggctgg tcctcgtccc agtagagcct gacgaaccgg tcgtcgtcga tgtagtcgtt
    12961 ccgctctccg tcctggccga tcaccgggag gaagccgcac atcttcacgg agtcggacgt
    13021 catccggtcc ttctcgcgtc ggaacgccac ggaccgcgac agcccgcgcc atcgcagcgg
    13081 gacgacgagg cgtccgccga cggcgagctg gtcccaccag gttccgggga ggtcccacat
    13141 gccgacggcg gcgatcatgc ggtcgtaggg gctgaactcc tcggcgccga gggcgccgtc
    13201 cctggtgacc acgcgaacgt cgtcgcaccc gttcgcgtcc agctcgggag ttacaccgct
    13261 caccgtacag accctggcgt gccgcgcgtg cgactgggtg gtcccggcgt cgatggagtg
    13321 ggcacggggc tcgggcctcg ggcctcgggc ctcgggcctc gaagagcgtg gggcggtggt
    13381 caggcgggga gccaggcggg ccactggggt gggacgttgc ttgtggggca gaggccggag
    13441 tcgccggggt agccgtccag ggtgcctcgg gttgcgaaga gccaccaggc cggcccgacc
    13501 gtcgccacga cgaccagcag cgtcggcagt gcggcgcgga gtgccctcgg tgcgcgaagc
    13561 gtcaggcgtc ggccgatggc cagtgccacg agcccgacga gcgcctcggc tcccacgacg
    13621 agagtgagca ggaagttgag ttcgaggcgt ccgccggcgt cgtaacccgc gtcgcagtac
    13681 gcgcgtgccc agacggtcag tgaccaggcg gcgcagccca tggcgacgcc gagcaaggcg
    13741 gagcacgccc agggaagaca ggaggtggaa ctcggctcgg atgtgtgcac gacatgacac
    13801 gacagcgaac gcaccgtcca tggttcctgg gtggggcgtg gggtgtgggt ggtcagaggg
    13861 tgagcgggag ggtcttcagg cctcgggtca ggcgggtgtg gcgccagggg agggtttcga
    13921 cgggggccgc caggctggcg tgggggtggc gggtgatgac ggcgtggagg gcgagttcgg
    13981 cctcggctct ggccaaaggg gcacccaggc atcggtggat gccgtggccg aaggcgaggt
    14041 gtcctgcggc ggggcgggtg agatccaagc ggtcgggatc ggggaatcgg tccgggtcgc
    14101 ggttggcggc gccgggtgcg atgaggaccg gggcgccttc ggggatctcc gtaccgccga
    14161 gtgtgagtgc ctcggtgctg tagcggaacg tggcgatccc gacgggcgag tcgtagcgca
    14221 gcagctcgtc cagcgcgctg ccgaggagct gcggctcggc cctcagtcgc gcgagtgatt
    14281 ccgggtgccg gaggagggcg agggccgcgt tgccgatgaa gttggtggtg gtctcgtggc
    14341 cggccaccag caaaagtacg gcgagcgata cgagttcgtc ctcggacagg cggtcctggc
    14401 cgtcgcgtac ggcgatgagg tcgtcgagca ggctggtgcc gggtgcggtg cgcttggtgg
    14461 cgacgagggc ggtcatatag tcgccgacgg cgtgggaggc ggcgtcgatc cgtcgcgggt
    14521 ctccggcggc gaacaggtcg ctcgaccagg tgcgtacgga tgcgcggtcg gactcgggca
    14581 ccccgagcag ctcgcagatg accgtgacgg gcagcgggac cgcgaggtcg gcgacgaggt
    14641 ccaccgttcc gtggtccggc catgcgtcga gcaactcgtc gacgaggccc gagatgtagg
    14701 ggcgcagccg ggcgaccgcc ccggtggtga acgccttcgt caccagcgcc cgtagccggg
    14761 cgtggtgcgg gggatcggtg gcgagcatgt tccgggagac ggccgggtgg agatcgcgtt
    14821 gcgacggccg accggcgaag aatttcgtgg tgtccttcga gagccggggg tcggtgaacg
    14881 cctcccgggc ctcggtgtag ccggtgacca ggtagctgtg gcggcctcct gaaccggtgg
    14941 gtaccctgcg taccggtgcc gcttcgcgca ggcgggcgta cgtggggtag gggtcggcga
    15001 agaatgcggg gtcctgcaac gggtcggttg cgctggtggg gcgggggtcc tcggttgggt
    15061 ggggggcctc ggtcgggtgg ggggcttcgg tcgggtgggg ggcttcggtc gggtggggcg
    15121 ggttggtcac gttcggggat ccgttccgga cggtgccagg gggtcggtgg tgggggtggt
    15181 ttcgtgctgg gtgtatgcct gggctacgag cagcagccat tcggtctcgg ctcggaggtt
    15241 gcccgctcgg gaggcggttc tggagggcgc gggtgcggct ccggttctaa gttcgtttcc
    15301 ggtcctgggt tcgcttcccg ttctgggttc gcttcccgtt ctgggttcgc ttcccgttct
    15361 gggttcgctt cccgttgtct tcgcgtgtac ggccgcgcgc aggatcgcgg cctcgacgat
    15421 ggcgtctcct tcctgggttc ccgtcaagcc gcgtgcggcg acggcccgtt cggcgctctc
    15481 ctggacgcgc accgagcggt gggggcgaag ggcgagcact ccgtcgttga tctcgatcac
    15541 ccggcggtgg aggtggaagt cggagtcgtc cacgtgctgc gaccccgccg ggcccaggac
    15601 gacctcaggg gtcgtgtcgg tgatgtcctt ccacaggggg gccagcgcgg cgaacgacct
    15661 cgactcccag cgacggcgca ggaactggct gaacggccac acgaccgccg ggagggtgag
    15721 ccccacggtg acgaggagta ccgcgaccgc cggcgccgtg acgctgaaca cgcagcggac
    15781 ggggctgatg ggcgtcgagc atcggacgcc gtgcggcagg aggtccagtt cgagcccgat
    15841 ggagaccagg ccgaagacct tgtaggcggc gtacagcagg gcgaagacgc agccgacgga
    15901 ggtgatgcgc agtcctacgc gctggctctt gcggcgtgag tggccggcct gtttccaggt
    15961 ctgcgtgccg aagtccttcg cggtgacgct gaggtacgtg acgtagatca gcacgtagag
    16021 cgcgtacagc tggggtgaat cgtcgttcaa ctggctggcg gtgaacagca ccgtcatggc
    16081 ggtgacggag atgccgagga agagcacgcg ccgtcggatg ttccgccggg cctcgtcggg
    16141 ttcctggtcg agctggagca tgaacgccag gacggaggtc gcggcggtca gcgtgaagga
    16201 gttgctgagc aggcgcccgc cgtcggggac gacgctttcg acggcgttct ccacgacgga
    16261 cacgtacgag ccgaaggcac aggcgaagga gacgagcagt gccgccatgg cccaggtgcc
    16321 ggtcggccgg tggccgcccc ggccccggac ccagtacccg gcggcgagca gcagcacgag
    16381 ggccacgcct gcgaacaaga ggtcgatcat cggcgccgac ggcccttcct ggtgggtttg
    16441 gcgaacaggg cctcccagcg ttcggcgccc ttctcgggct cacggggagg taactcacgt
    16501 ccgcggtaga tgtgctgccg gatgacggtg gccatcgtct cggcctcgcg ctcgtcgtcc
    16561 gtggagtagc tcgtgcgtcc gttcatccgc tgcacgaggg tggggttgaa gccgagggcg
    16621 cggaaggcgt cggcgtccag ctccagcgtg ccggggtggt cgcagatgat gtggctgacc
    16681 tcgtgcgcga ggatgtggtt ctggtgcagg gcggacgttc cctcctcgta gaagaggagg
    16741 tccgcgtcgg gtgtctccag gcggatcccg cagggtgcgt cgatcgcgcc gagggtgctc
    16801 agcggcctca ggatgatcgg acggccgcgc atctccgcca cggcgtcgca gaggtctcgg
    16861 gtgttgaagc ggtgagggag ccgaagcgcg tccacgcgtt cttcgcaagc gcggcgtaac
    16921 cgctcaaggt ccatgtccgg tcctgacgtt gctcgggtct ggccgctgac ggcgtgaccc
    16981 cgtaaggccg gagtgcgatc cgggatcccc ggcaccgaat cgttcgaaag cttaggcgaa
    17041 cacgcaggcc ggtccaaggg aatctcggcg ctctggccga atggccggat ctcgcgattc
    17101 gcccatcagg tgagggcgcg tttcatctgg gcaaaggcag gttttcgagc cggggccggt
    17161 ttcctgtccg gggctgattt tcgggttgag gccgaattac tgtccggggc cggttcgagt
    17221 ccagggagca ctccgggtcc gggtccggtc caagtccggg tccgggtccg ggtccgggtc
    17281 cgggtccaag tgcaggtccg ggtccgggcc caggtccaag tcagcggctg gcggcggggc
    17341 ggtggcccgt ggtgggccgg tggccggcag cggccagcag ccaggtgcgc cccgcgcccc
    17401 gcgccccgcg cccgcttaat tgtccaagtc gaggccgttc gagggtgttt cgcccggaag
    17461 gccctccagg atgcgggcct gctcgatcac cgccgtcacc atctggaggg tctcggcact
    17521 gagaccgttg gcgcgcaggg ccacggtgcg gacgttctgg tcccgcatgg cggcgaggac
    17581 cgcgatctcc gctcgggtgc gatgggcggc ctgctcgtcc acgaagtagc cggcgggcac
    17641 gccgaagaag tcggcgagcg ccttgatggt gtgccttgtg gggttcttct tggcaccggt
    17701 gcgcagttgc tggatcgcgc tcgcggtgag ccccttgccc tcgtcgcccg aagcctctcg
    17761 gatcccttcg gcgacctcgg cgtacgtgta gggcccgcga cccgccgggt ggacctcctg
    17821 gaagaggtgg tccagcaact gcgcgaaggt gcgcggctcg tcgtctgtca cgtccggtac
    17881 gtcctgtcct gatcgccgct gtgtccactc tggtgtgcgt gagcgcggaa cgtggtggct
    17941 tctgctcaac tttagttgac gatcgcccac aactacggtg tacgttctac gggggtcact
    18001 cacaccagag tgttccatgg ctccgatcag ctgtcttcgg cacgggccat gagagacctc
    18061 ccagccgggt ggccgggttc cgcgggggtg ggcccggcca ccctggagcc tgtcttcgct
    18121 tcccgttcga tgtgcccggt tccgcgacgg cgccctgggg ccgcttcgtt cggcaccggt
    18181 ccctccccac gtggggaccg gtgccgaacg gtgcgggggt gtcgatccgc gcttggggac
    18241 gcggatcgag gaggttgtgg ctgggggcgt cgctgagggt ggccggaagc gtgcggcatg
    18301 atggatcgga tgtgcgggcg ctacgccggt ggcccctgcg ggcagtgcac cggcgtgggc
    18361 ggctcgggcc cgatcctgcc attcggggct ggcgggagag aaaggccctg gtgtccggtg
    18421 acggcgtttc cgcaggtcag accagcaagg tgagttttcc ggtccggatg tccacgtagt
    18481 gggggaagtt aaggggtaga tgccttgagt cacgactcag aggcacgcac ggccttcgcg
    18541 gaacgtctcg cgctgttgta caaggaagcg ggcaatcctc ccctcaagag cgtctccgag
    18601 tcggtcgtcc ggctccagcg ggtcgatgag cgcgggcgcc ccgtacgggt ctcggcccag
    18661 cgaatcagtg actggcgacg ggcccggaac gtccccgcgc agttcgccgc cctcgcctcc
    18721 gtactgcagg tgctgatccc cgaggcccgg cgtgcgcggc ccgttccggt gtccaagggg
    18781 ctgtacgaca tggcccagtg gcagcggctc tgggagcggg ccctggccga tcccgtcggg
    18841 gagcgcccgg cggactccgc gtccggcacc gcgaccgccg cgtccggcgc cggcatggac
    18901 gagcagcctg ccggcgaggg ctcgtccctt cctggtggtg tctgccccta ccggggactg
    18961 gcctcgtacc ggcagcagga cgcacgctgg ttcttcgggc gggagcggag caccgatgcg
    19021 ctcgtcgagc agttgcgcgc ggcggggcgc accggcggcc tggtcatgct cgtgggtgcc
    19081 tcgggcgccg gaaagtcctc actgctcaat gcagggctcg tgcccgccgt gcgcggcggt
    19141 gccctggacg acggtgacgc cggccaggta ggcgcagggc tcgggagcgc gggcaccgcc
    19201 ggtgggcgga gggtcggcga ggtgctccag ctcgtgccgg gtgccgatcc ggtcggcgag
    19261 ctgacccgtc acataccgga gctggggcag gtcgtgtccg ccgcctacga gcccggtacg
    19321 ccgatgttcg ccgaggcggt acgagaggcc gtcgcgacgt gggcacgccg acgcgggacc
    19381 gagcaccatg gcggcgacgg gaggggcggc gaggcgaggg gcggcagcca ggagagcggc
    19441 ggcagcggcg aagcccggga cggcggcgcc cgaggcagcg gcagcggcag cggcagcgag
    19501 accaggggca cccccatccc catccccacc ccaacccccc tccgccccgt cctgatcgtc
    19561 gaccagttcg aagagacctt cacgctctcc tccgacgagg cggagcggcg gacgttcgtg
    19621 cagttgctca gtgcggcgtg cacgcccgga gaggagggcg gggcggcgcc cctggtcgtg
    19681 gtgctgggcg tgcgggccga cttctacgag cagtgcctcg gctatccgga gctggcggac
    19741 gctctgcagc accggcacat ggtgctgggg ccgttgacca cggcggagct gcgggaggcg
    19801 gtgaccggac cggccaaggc cgtggggctg gagctggaac cggggctggc ggagctgatc
    19861 gtgcgggagg tgagcgcgga cgggccgcgc ggggcgcacg acgcgggcgt gctgccgttg
    19921 ctgtcgcacg ccctgctcgt gacatggcag cggcggaagg cgggccggct gacgctggcc
    19981 ggctatcggg cagccggcgg tatccagggc gcggtggcgg ccaccgccga gcgggcctgg
    20041 tcggggctgg acccggcggc ccgttcggcg gcacggctgc tgttgctgcg gctggtccgg
    20101 ctgggagagg acacccaggc cacccggcgc cggggcacca ggcggcagct cgcggacggc
    20161 tcggcggacc cggagaagac cgaggagtcg ctggaggcga tggcccgcgc ccggctgctg
    20221 acgctggacg cggagaccgt ggagatcacc cacgaggcgc tgctgcacgc ctggccgcgc
    20281 ctgcggagtt ggatcgacga gggccgcaac gaccatctgc tgcggcagcg gctggaggag
    20341 gacggccgcg cctgggagga ctccgaccgc gattcctcgc tgctctaccg gggttcgcgg
    20401 ctcgaacagg cgcacacctg ggcgaagtcc accagggaag ccgggggcag cgggggcagc
    20461 gggggcacca aggaccccgg agacgtcggg gacaccgggg gcgccttcct gacccggagc
    20521 gcggtggagt tcctggcagc gtcggtccgg ctgcaccggc gtaccgtccg gatccggcgg
    20581 agtgccgtgg cggcgctggt ggcgttcgcc ctggtggccg tcggctcggc ggtggtggcc
    20641 tggcagcagc gcaacgacgc ggtgttcgag caggtggtcg cccaggccga tcgggtccag
    20701 tactcggatc cgtcgctgtc ggcccagctc gacctggtgg cgcacgatct ccggccggac
    20761 gacgagggca ccgacaaccg gctcgtctcg atcgtcaacg cgcccctggc cacccctctc
    20821 ctcggccacg gcggtgccgt ctacctcacc tccttcagcc ccgacgggaa gtacctggcc
    20881 accgccagct acgaccgatc cgtacggctg tggaacgtgg cggacccgtc ccggcccacg
    20941 gccctgggca agcccctcac cgggcacacc agttgggtga gcagcgcggt cttcgcaccg
    21001 gacggccgta cgctcgccag cgccggcgac gacggcacga tccgtatgtg ggacgtgcgg
    21061 gacccgcgtg cgccgcgcgc gctgggcgca ccgctgaccg ggcacgacgg cacgatcttc
    21121 ctgatcgcct tcagcccgga cgggaagacg ctggcgtccg tgggcgagga ccgcaccgta
    21181 cggctgtggg acgtgagcga cccggcgcac gccagggagc tcggcgcgcc actcaccggg
    21241 cacagcgctc ccgtacgcgc cgtcgcgttc ggtccggacg ggaagacgct ggcgaccggg
    21301 ggcgacgaca acacgatccg gctgtgggac gtggccgacc cgcgtgcgcc gcgcgcgctg
    21361 ggcaccgtgc tcaagggcca tacgagt
//
