LOCUS       NZ_CP080647            28040 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces akebiae strain MG28 chromosome, complete genome.
ACCESSION   NZ_CP080647
VERSION     NZ_CP080647.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces akebiae
  ORGANISM  Streptomyces akebiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10257202)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2021) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019599145.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:26:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,127
            CDSs (total)                      :: 9,036
            Genes (coding)                    :: 8,727
            CDSs (with protein)               :: 8,727
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 142 of 309
            Pseudo Genes (incomplete)         :: 231 of 309
            Pseudo Genes (internal stop)      :: 20 of 309
            Pseudo Genes (multiple problems)  :: 77 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4423474
            Orig. end                         :: 4451514
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP080647.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28040
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /product="betalactone"
                     /region_number="15"
                     /rules="AfsA"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..28040
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="neighbouring"
                     /product="butyrolactone"
                     /product="betalactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10897
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10897
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5897](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5897)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(320..333)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.14"
                     /tool="antismash"
     cand_cluster    555..28040
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    555..28040
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10554:18040](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10555..18040
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
     misc_feature    629..644
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    1086..1100
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.17"
                     /tool="antismash"
     gene            complement(1845..3635)
                     /locus_tag="K1J60_RS46780"
                     /old_locus_tag="K1J60_19000"
     CDS             complement(1845..3635)
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024758.5"
                     /locus_tag="K1J60_RS46780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19000"
                     /product="serine protease"
                     /protein_id="WP_263013084.1"
                     /transl_table=11
                     /translation="MGELRADWRLRLRRGSARGPICGAGVLVDQNTVLTCAHVVRHPDA
                     VMWVEFAENSELEPVSARVLPGGWLAGSDVGGGRVGQAVGEPVGDVVGEDVAVLRLDSP
                     RPQARPARLETRLWGGMEVSATGYAEGFDDGMSLWGRIGGVSGERVQLDAVTKAEVVRR
                     GFSGAAVCTRPEEGRAARVVGLVVSWRGDMGELLPENNRLAFSYLIPVARIAELSPVIA
                     ELCGPHAWDHDFEERLTRWFGDECADEEPVKVTVVPPGSGKERSLRHLVHRADLVYRGG
                     GSSRPDLADHALGHIAFPPGRYLAYWDWLLGTRPPPGRPPALVGGRRVTVVVDGLDEEP
                     EPGALIALLARLRSLGFRLLLVFRQEGGTGWTAARDDLLAPALLDHADALLARLERAEF
                     SRAVRHGVVDSASLGSLTETAERRRGERRSIDAAGGTGGSGSGSGSGGSGGFGEGGGFD
                     GGRGFDGGGGVGRAGGTQRDRVGRGAHGFGGAGGGMDPQQRLARLRELIRTLRADLRRI
                     GERAGGERPVAEQAPGGEPPGERASGGWSAGGRPTGKRASGGRADGARPSGERAAGGWP
                     TGDRVSGDRPSGDWPSGGLT"
     misc_feature    complement(2580..2582)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3728..4021
                     /locus_tag="K1J60_RS19005"
                     /old_locus_tag="K1J60_19005"
     CDS             3728..4021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433622.1"
                     /locus_tag="K1J60_RS19005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19005"
                     /product="trypco2 family protein"
                     /protein_id="WP_045563122.1"
                     /transl_table=11
                     /translation="MSDTEPVGLAEAIGTVRAELARAQAEGAASDWRFSVEQVSLEFAV
                     QFHRSGEGGAGLRLGVVEARLGGTVSHDSTHRIQVDLKPLPGPTGHHHEVGR"
     gene            4137..4901
                     /locus_tag="K1J60_RS19010"
                     /old_locus_tag="K1J60_19010"
     CDS             4137..4901
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-171). E-value: 4e-13. Score:
                     41.6. Matches aSDomain:
                     nrpspksdomains_K1J60_RS19010_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155345.1"
                     /locus_tag="K1J60_RS19010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19010"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_220647243.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-34, bitscore:
                     118.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.7e-30, bitscore:
                     104.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISDLLADKVVLITGASSGIGAAAAKVFSREGAVVVLAARREDRL
                     AALVSELRDKGAEASYVVGDMSVSADAGRAVDFAVAEYGRLDGAFNNAGIGGDRTPLHL
                     MTDDVYDTIMDVNVRSVWNCLRHEITAMLAHGGGAIVNNSSVAGVVAIPAAAPYIASKH
                     AVVGLTRAAADEYATRGIRVNAVAPGTTRSEITVDWFARNPGLEERVNSLTPQGRTAEP
                     EEIAEAAAWLLSDRCPFLTGAVVPVDGGFVNH"
     misc_feature    4145..4154
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     misc_feature    4152..4154
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       4164..4259
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K1J60_RS19010_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K1J60_RS19010"
                     /protein_end="41"
                     /protein_start="9"
                     /score="10.7"
                     /tool="antismash"
                     /translation="VVLITGASSGIGAAAAKVFSREGAVVVLAARR"
     aSDomain        4164..4649
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K1J60_RS19010_PKS_KR.1"
                     /evalue="4.00E-13"
                     /label="K1J60_RS19010_PKS_KR.1"
                     /locus_tag="K1J60_RS19010"
                     /protein_end="171"
                     /protein_start="9"
                     /score="41.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGASSGIGAAAAKVFSREGAVVVLAARREDRLAALVSELRD
                     KGAEASYVVGDMSVSADAGRAVDFAVAEYGRLDGAFNNAGIGGDRTPLHLMTDDVYDTI
                     MDVNVRSVWNCLRHEITAMLAHGGGAIVNNSSVAGVVAIPAAAPYIASKHAVVGLTRA"
     gene            complement(5001..5897)
                     /locus_tag="K1J60_RS19015"
                     /old_locus_tag="K1J60_19015"
     CDS             complement(5001..5897)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041195.1"
                     /locus_tag="K1J60_RS19015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19015"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_259407788.1"
                     /sec_met_domain="AfsA (E-value: 2e-18, bitscore: 65.3,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGAIGAVQPALHGAVDMARLGEYTHLRHDSAIVVRDWRRTGPDT
                     FTVAARWPGYRGPGRYDPRLLAQTIRQSGLLVAHAEYGVPTGHQTLLSNLRITAEAGFQ
                     AREASDFEVDIAVTRSGRRSASLGMEFRIRRDGATVCLADTEFGWVSPAAYRRVRGPHL
                     TVAWGEWPVPEPIDSHLVGRADDSDVLLAAGPADHQWQLRNDVSHTLLFDHPVDHVPGL
                     VLLEAAHQAAHAAAGPTPVELTDISIGYERYVEFDEPCWIEARRLPTLLPDWCAVVVTG
                     RQGGEVAFQARLRGLLT"
     misc_feature    5907..5923
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.84"
                     /tool="antismash"
     misc_feature    5910..5926
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.11"
                     /tool="antismash"
     misc_feature    5911..5921
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            6046..6696
                     /locus_tag="K1J60_RS19020"
                     /old_locus_tag="K1J60_19020"
     CDS             6046..6696
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047020.1"
                     /locus_tag="K1J60_RS19020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19020"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_317619717.1"
                     /transl_table=11
                     /translation="MRQDRAIRTRNLILESMASLFNEVGYDAATIAALVERTGLTRGAL
                     YFHFASKEDMARAVLDEAVTREGFSPQAFKMQEWVDLGLLLAHRLPREPILRAAIRLAV
                     DPKARRLFGTRWPDWVTLGHTLLTEAKESGELFGHADPAAISRAFVGAWTGVQLVTEAL
                     EEKLDLSEEIAGLYQLLLPSIVTPAVLARLDLSPHRAERLLRESRGQEAPEHE"
     misc_feature    complement(7045..7058)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    7053..7062
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            7098..7787
                     /locus_tag="K1J60_RS19025"
                     /old_locus_tag="K1J60_19025"
     CDS             7098..7787
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740558.1"
                     /locus_tag="K1J60_RS19025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19025"
                     /product="response regulator transcription factor"
                     /protein_id="WP_220647245.1"
                     /transl_table=11
                     /translation="MAVHAAQPDTTRVLIVGDDADAAEARARELRRQGYHAQSVVTGAE
                     ALNAHQQADLVLLDLDLPDIDGLEVCRSIRQAGDKPIISVTARNTELDRVLALQAGADD
                     CVVTSCGEREMLARIEAVLRRARPRTERSRPLCLGPLHIDSRTREVRLHDRPVNVTAKE
                     FELLHTLAATPESVISRKELMARVWETGWADSSRTIDTHVRSLRAKLGTHSWIITVRGV
                     GYRMGHG"
     misc_feature    7593..7595
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7882..9138)
                     /locus_tag="K1J60_RS19030"
                     /old_locus_tag="K1J60_19030"
     CDS             complement(7882..9138)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.5"
                     /locus_tag="K1J60_RS19030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19030"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_220647246.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.6e-14, bitscore:
                     52.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.2e-17, bitscore:
                     60.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-29, bitscore:
                     102.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTHADYVSGNRAVPDFPDFPAFPGIAARAAETDATGRIPAQN
                     WKELADSGYLRLFHPPEIGGTGADGLTQADAMEALARACPGTYWAATVSTLLCGKLIST
                     YGDLRHHEPLLRALLSGERLAAFAVVERTAGSDAGTYRTTVRPAREPEGGFVINGEKSR
                     ITNAPVADVAVVLARRERLPGDDGPDWCLAFVDLNQPGVERYEIAHMGLRGMPWGGIVF
                     TDAHIAASDVVPVPFGELAEGMAWGWLKNSFAAIAVAESALAASVRHARERVSFGRPLA
                     HMEGVQAQLAESRAQIDAARLLARRAMCARVEGRSVRDLIAMLKIYATEMGVEVAARAV
                     QIHGATGVTQGHEVERLYRDAQMNVIGGFTSNRLREQVAENIGLGPAVYSAFDWVTPAG
                     LGQDPAGLDGSPYAQGAVT"
     gene            complement(9179..10324)
                     /locus_tag="K1J60_RS19035"
                     /old_locus_tag="K1J60_19035"
     CDS             complement(9179..10324)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.5"
                     /locus_tag="K1J60_RS19035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19035"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_220647247.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.3e-14, bitscore:
                     51.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.6e-24, bitscore:
                     83.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIPHFPTGEWARELADRLAGPTTAERDRECRWDPRLFAELVAAR
                     PGPGLAGPLVPPDLGGAGLSATEAVDLLAGLGEGARDPGLALAVAVHAVLATVPLRAFG
                     TPGQRERYLPRMASGEWVGALSLQQTQGASLAPTVTVRPAAEGAGGWVLTGELDLVAGA
                     PVAHHFLVVAAHDDGRRTAFVVDRAGERLWVDEARPAAMPTCPWGRLVLDGRAVADTAV
                     LGSVGGAATEVEPLLAVLDWVFSSAPWLGLIRALTRDAVDGARERRLFGRPLHHDQSVR
                     FTLADLAARCELAEGMLYRAAEQFDSGDRPSHQDAAAARLFVAAAVRTVTDAAVRLSGP
                     LGLSGDHLVGRAHRDGLFFAGTGGGTEVLRPVIAASLLELG"
     misc_feature    10376..10391
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    10376..10394
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    complement(10378..10391)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.77"
                     /tool="antismash"
     misc_feature    10452..10466
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.79"
                     /tool="antismash"
     gene            10555..11706
                     /locus_tag="K1J60_RS19040"
                     /old_locus_tag="K1J60_19040"
     CDS             10555..11706
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947770.1"
                     /locus_tag="K1J60_RS19040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19040"
                     /product="isopropylmalate synthase"
                     /protein_id="WP_220647248.1"
                     /sec_met_domain="HMGL-like (E-value: 3.9e-48, bitscore:
                     163.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVAEHGGSLPRLPHLSDATLRDSAHMAGVEFGPKDAAVIADLLV
                     KTGIELVEVGMVSGPGSKDADLVLATHEAVGPERSMTLVVVRDRQQVAKALDEAERLGV
                     RHIMYSIPTSEQHAKLKLGSPSAKFLQTLARSAITQAKERGFHVTFSGEDGARTPRERL
                     VPYVTAGFEAGADRFRLAETVAYLSPWQMEEVIADLTAIDGSEIEIHSHNMLGMAVANS
                     LAAVRAGAQWISATVGGIGERGGNAPLAELLTSLRVIHGDTRFDLSHLTELSRVALKGA
                     GLGDSFQSGPTTPHAFAYELPGQLTHPEAYETLPAELVGNARELRVRTRLTPALVKWAL
                     AESGVSVDIDAFTPWLIERQERDGGPLLDRDTIRKAAIDFQAA"
     gene            11777..11962
                     /locus_tag="K1J60_RS19045"
                     /old_locus_tag="K1J60_19045"
     CDS             11777..11962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="K1J60_RS19045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19045"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_220647249.1"
                     /transl_table=11
                     /translation="MSTALLTGDCPECETDLTVPPMVQGETLSCPECMLTLRVEEIQNG
                     RLSLQMVEVQLRDWGQ"
     gene            11964..12812
                     /locus_tag="K1J60_RS19050"
                     /old_locus_tag="K1J60_19050"
     CDS             11964..12812
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645498.1"
                     /locus_tag="K1J60_RS19050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19050"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_220647250.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.8e-09, bitscore:
                     35.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.7e-21, bitscore: 75.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.4e-07, bitscore:
                     30.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLNVAIVADRVGWEERELIRRAPDLGLRIDWVNDESLCLGDTKA
                     PSIDGYDALLVRSRSYTRGGLLATLAESGGVPVLNSAGAIHACENKLVLRSELRSAGVP
                     VPDFRLALSRKDFTRALDDLGLPVVLKPVYGGMGKRVTLVREADLAQSVYDYVEDLGHA
                     FEQACLVEPYLGGGSVRALVVGRRIVAAAEFESAGADWRSNAALGNQSRALAHDPEVQK
                     LVDGVVDRLGEGIYGVDLFKTPSGHVVNEVNHAPAWRGVASTTGADIPSAIARHLQETY
                     A"
     gene            12809..13867
                     /gene="argC"
                     /locus_tag="K1J60_RS19055"
                     /old_locus_tag="K1J60_19055"
     CDS             12809..13867
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379927.1"
                     /locus_tag="K1J60_RS19055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19055"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_220647251.1"
                     /transl_table=11
                     /translation="MIRVGIVGASGLTGGELIRLVSQHPELELTFLGGNSSAGRRPAQL
                     HPGLRLDLGLTVERVTAEAVAERCDVVFLATPAPASAELAALLADRVPCVVDLSGAFRI
                     RTPRLHERWYPKATRSDELADRFVYGVPELVGDQLAGAPLISVPGCYATAITLGLAPLT
                     LGLGLNLKTVVVDGKSGSSGGGLQLRVPDLHPLRNGAIAPYAPTGHRHAAEVGDFLEHS
                     KPGTVGSLTMSAYGVSHVRGLLASTYVFTDDEVDGRELQRAYLRFYKGHRFVRVRRHTE
                     TLIPVPDPQAVLGSNFCDVTVLYDDEGGRIVVLAALDNLVKGAAGQALQSMNIRFGLPE
                     ETGLTMQPVMPA"
     gene            13864..14667
                     /locus_tag="K1J60_RS19060"
                     /old_locus_tag="K1J60_19060"
     CDS             13864..14667
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947774.1"
                     /locus_tag="K1J60_RS19060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19060"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_220647252.1"
                     /transl_table=11
                     /translation="MSETITQRTPTVVKLGGSCLDDLAGDWWDDLARHGRQRPLVLVHG
                     WSKPLKQLSPRHSEPSAILRDRYGNQSRWTTPEVISDIKTVSLRLGEDVLDRLEQRGIT
                     AERLLGSDGLVSAGEGERWWWRNKQLVELENLVGPITGVDPSALKNLQPGHAYLVTPLA
                     RNAAGQEVNTDADRAAAAVAGATGAEDLVLVTDVAHLLIDGEPVRRITARAAAEFRDKG
                     ATGGMRKKLRAAGEALEQGVERVVIGSAPVTELLAARTGTVITRT"
     gene            14673..15242
                     /locus_tag="K1J60_RS19065"
                     /old_locus_tag="K1J60_19065"
     CDS             14673..15242
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609639.1"
                     /locus_tag="K1J60_RS19065"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26.; Members of
                     this family of hydrolases with an active site Cys residue
                     belong to MEROPS family C26.; Members of this family of
                     hydrolases with an active site Cys residue belong to MEROPS
                     family C26.; Members of this family of hydrolases with an
                     active site Cys residue belong to MEROPS family C26;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19065"
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="WP_259407790.1"
                     /transl_table=11
                     /translation="MRVAQSRVLVVNNGTLSLKQLRKRFEQLGSETEAVDAASVPNRLD
                     GRYQAIVLSGTKVRAYDRDYYKPLIDLVMSADVPVFGICGGMQILAVAAGGRLAEGPQR
                     VGGYEVQVDKEEPLFTHVKPTVTVFHRHTLYLQEAPPGFRSIGRSEHAPVEFLRSDDGR
                     ILGSQAHLEFRGDGLEILRGFAQLYQ"
     gene            15270..16388
                     /locus_tag="K1J60_RS19070"
                     /old_locus_tag="K1J60_19070"
     CDS             15270..16388
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609640.1"
                     /locus_tag="K1J60_RS19070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19070"
                     /product="Glu/Leu/Phe/Val dehydrogenase dimerization
                     domain-containing protein"
                     /protein_id="WP_220647254.1"
                     /transl_table=11
                     /translation="MSDLETPHDPAFTVHLNGSGGALRGWVVVDSLYDGLAMGGVRMTT
                     GVTEEEVAGLARDMTHKFILAGLPIGGAKGGIVSDGTDREETFRTFGRTVKPLLHGGIH
                     LGIDMGVTPADRAVFFAEAGYDPRYRLGAPDMPIDWRTYYEPLIDCTGHGVGVAAVTAL
                     EANGRTGPARIVVQGFGAVGRAVARFLEERGHVIVGVADVHGTVSADRLPVADLIAVTD
                     EFGLIDRSRLPQDVTCSTEPDAWLDVDADLLVLAAQKNALNADNAHRLRAHLVVEGANL
                     ASSAEAREKARASGATLVPGVIANIGGAGSAALAVTRVVPFDLAAEARKAWVFDWIGDR
                     VRRNTRDLLDIGAANPGDPLPELLETRRKERG"
     gene            16385..18040
                     /locus_tag="K1J60_RS19075"
                     /old_locus_tag="K1J60_19075"
     CDS             16385..18040
                     /NRPS_PKS="Domain: AMP-binding (36-452). E-value: 2.5e-83.
                     Score: 271.9. Matches aSDomain:
                     nrpspksdomains_K1J60_RS19075_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947777.1"
                     /locus_tag="K1J60_RS19075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19075"
                     /product="AMP-binding protein"
                     /protein_id="WP_220647255.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-84, bitscore:
                     283.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTTAILATASAADRMAEYRRRGWWRDETFLDDLRRQARERPR
                     KLAVAGRRLDEARTDTLDYAELARLTDRFAGALLELDVRRGDVVAVQLPNRWEMVPLMF
                     ACMAVGAVICPIAPVCREEELRHRLALTEAKVCVTVPEWEGFPLAETVTALKEELPLDH
                     VVVVDGHAPEGALDFHDHFVATPWEKRRTADLEGRQLRPDEPFVVLFTSGTTGFSKGVV
                     HSQNTVHSGVRGYVDTFMLRDDLVVVVTTPLVHYSGLGQGVLAGVMLGGTVVFQDGGDH
                     TGLLDLVERYGATLLYGPPPTLSGVARAQRIDPHDVSSLRHTVTGAAPVLQPLVDELRQ
                     TFGARTYSVWGMSEFGPVTISRLDYNQDWAAHSHGRPIDSMEIRIDLCHDPSKRAPVGR
                     LRARGASRALGYYKHQDAFDAELTEDGWFDTGDVAREDGRGGIRILGRAKDTILRDGIV
                     VPMAELEAILSRHPKVTEAALVGPHGTVDDPILVVVVPRGDATVTLEEIRAYLREAGQD
                     PRFYPERLEIVTALPKTLTGKVRKVELRERFAGA"
     aSDomain        16493..17740
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K1J60_RS19075_AMP-binding.1"
                     /evalue="2.50E-83"
                     /label="K1J60_RS19075_AMP-binding.1"
                     /locus_tag="K1J60_RS19075"
                     /protein_end="452"
                     /protein_start="36"
                     /score="271.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRQARERPRKLAVAGRRLDEARTDTLDYAELARLTDRFAGALLEL
                     DVRRGDVVAVQLPNRWEMVPLMFACMAVGAVICPIAPVCREEELRHRLALTEAKVCVTV
                     PEWEGFPLAETVTALKEELPLDHVVVVDGHAPEGALDFHDHFVATPWEKRRTADLEGRQ
                     LRPDEPFVVLFTSGTTGFSKGVVHSQNTVHSGVRGYVDTFMLRDDLVVVVTTPLVHYSG
                     LGQGVLAGVMLGGTVVFQDGGDHTGLLDLVERYGATLLYGPPPTLSGVARAQRIDPHDV
                     SSLRHTVTGAAPVLQPLVDELRQTFGARTYSVWGMSEFGPVTISRLDYNQDWAAHSHGR
                     PIDSMEIRIDLCHDPSKRAPVGRLRARGASRALGYYKHQDAFDAELTEDGWFDTGDVAR
                     EDGRGGIRILGRAKDTI"
     CDS_motif       17006..17056
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K1J60_RS19075_0001"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="K1J60_RS19075"
                     /protein_end="224"
                     /protein_start="207"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VLFTSGTTGFSKGVVHS"
     gene            18121..19392
                     /locus_tag="K1J60_RS19080"
                     /old_locus_tag="K1J60_19080"
     CDS             18121..19392
                     /NRPS_PKS="Domain: Aminotran_1_2 (28-380). E-value:
                     3.6e-46. Score: 149.9. Matches aSDomain:
                     nrpspksdomains_K1J60_RS19080_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609642.1"
                     /locus_tag="K1J60_RS19080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19080"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_259407791.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.3e-44, bitscore:
                     149.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARVPVTMSATLAADEALARRQRAGEQVLSLASGEIGLPVLPAL
                     RERLAAAADRNAYGSVAGSPRLRSAVAGYWGRRNLSVDPGLVVCGPGSKPLLFALLLAV
                     GGDVVVPVPSWVSYAAQARLVGARPIPVPVLPGEGGVPDPAALREAVARARAAGRDPRC
                     VVVTLPDNPTGTVATAGTVERLARAARDLDLVIVSDEIYCDLVFDPADRAVSPAAFAPE
                     RTVVTTGLTKNLALGGWRLGVARLPDSPLGHEALTRLVGIASQIWSSTAAPVQSAAAYA
                     FEEPPEVVGYVAAARRLHEVVVRAVAERFTAAGAGLAPVRATCYLYPDFEPLRDHLAGA
                     HDVHGADALATLLAQRYGVGLLPGTAFGEEDRSLRIRVATSRLYGGTDAERFAALAADE
                     PARLPWVKASLDRITEVLTDLTTL"
     aSDomain        18205..19260
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K1J60_RS19080_Aminotran_1_2.1"
                     /evalue="3.60E-46"
                     /label="K1J60_RS19080_Aminotran_1_2.1"
                     /locus_tag="K1J60_RS19080"
                     /protein_end="380"
                     /protein_start="28"
                     /score="149.9"
                     /tool="antismash"
                     /translation="VLSLASGEIGLPVLPALRERLAAAADRNAYGSVAGSPRLRSAVAG
                     YWGRRNLSVDPGLVVCGPGSKPLLFALLLAVGGDVVVPVPSWVSYAAQARLVGARPIPV
                     PVLPGEGGVPDPAALREAVARARAAGRDPRCVVVTLPDNPTGTVATAGTVERLARAARD
                     LDLVIVSDEIYCDLVFDPADRAVSPAAFAPERTVVTTGLTKNLALGGWRLGVARLPDSP
                     LGHEALTRLVGIASQIWSSTAAPVQSAAAYAFEEPPEVVGYVAAARRLHEVVVRAVAER
                     FTAAGAGLAPVRATCYLYPDFEPLRDHLAGAHDVHGADALATLLAQRYGVGLLPGTAFG
                     EEDRSLRIRVAT"
     gene            19410..20327
                     /locus_tag="K1J60_RS19085"
                     /old_locus_tag="K1J60_19085"
     CDS             19410..20327
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947779.1"
                     /locus_tag="K1J60_RS19085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19085"
                     /product="fumarylacetoacetate (FAA) hydrolase"
                     /protein_id="WP_220647256.1"
                     /transl_table=11
                     /translation="MSILFECEYKGQRYAGVGVPAPGDTHVLHRVTEGQVRAAVIAARG
                     PEAVLAAVTEGAETVEVTIGDPELRFLPPLLPTSTNNALVNGFMGTHRSKFDHDPSPDE
                     EFTPPNYYQKGFGSWLRMPDEPLITPADPIWLIEEPEVALVYVNDDDGVPHYAGYTFGN
                     DLNDIGVHLKNPWAWTPYAKLCETSLAPWLFLDEPPRTVTGRVTIERDGAPAWEGDFSC
                     GGDSLYQRVEDMTAYVLSHPILRQPGLVNYLLLGADKATYHDGFRIEDGDRMVIDVSSH
                     GVVLANPVQYGQAATTDSRRTASR"
     gene            complement(20285..20659)
                     /locus_tag="K1J60_RS19090"
                     /old_locus_tag="K1J60_19090"
     CDS             complement(20285..20659)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009065143.1"
                     /locus_tag="K1J60_RS19090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19090"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_220647257.1"
                     /transl_table=11
                     /translation="MRIGELSERTGTPRRLLRYYEEQGLLVADRAPNGYRDYPEGCVNR
                     VLQIRGLLDSGLPTRIIKQILPCINDPRAIHVSDATPETIAALEGERQRMTDRIECLMR
                     SREAISGYLEAVRRESVVAA"
     gene            20723..21931
                     /locus_tag="K1J60_RS19095"
                     /old_locus_tag="K1J60_19095"
     CDS             20723..21931
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609630.1"
                     /locus_tag="K1J60_RS19095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19095"
                     /product="MFS transporter"
                     /protein_id="WP_220647258.1"
                     /transl_table=11
                     /translation="MSTSQTELLSDSAPAADNRKLPLSPLLALATAAFMGILTEALPAG
                     VLPEMARDMSVSESAMGQALTVYAIATGVAAIPLSVTTAAWRRKQLLLLAVTVFAVANL
                     VTALSSNYPLTMVFRLLAGVAAAAVWAELVGYARRLAPPHLQGRAIAITMAGVPLALSL
                     GIPLGTFLGGLFGWRMTFGLVTVISVALLGWIMVSVPDAPGQRPEAREPILKALSLPGV
                     AAVLFVVAAYVLAHNILYTYIATFLDAYDMGGSRDIVLLVFGIASVVSIWITGALVDRK
                     LRQLTIVSSALFLVASVLLAALAGNMIVVYTAMVLWGLGWGGVTTLLQTAVTDAGGDRG
                     QALLVTTWNSFMAGGGAVGGILLDGLGPKSFPWSVLALMAPVLLVVIAARKHAFPTTRP
                     GTD"
     tRNA            complement(22150..22223)
                     /anticodon=(pos:complement(4445661..4445663),aa:Thr,
                     seq:cgt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="K1J60_RS19100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="K1J60_19100"
                     /product="tRNA-Thr"
     gene            complement(22150..22223)
                     /locus_tag="K1J60_RS19100"
                     /old_locus_tag="K1J60_19100"
     gene            complement(22347..23933)
                     /locus_tag="K1J60_RS19105"
                     /old_locus_tag="K1J60_19105"
     CDS             complement(22347..23933)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (114-498). E-value:
                     1.2e-27. Score: 89.0. Matches aSDomain:
                     nrpspksdomains_K1J60_RS19105_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001768.1"
                     /locus_tag="K1J60_RS19105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19105"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_220647259.1"
                     /sec_met_domain="PF00561 (E-value: 9.4e-38, bitscore:
                     129.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTRRTSRPHRSLRAGGALLAAAALLVAGCSSGHSSAAATTVDGG
                     PALGPLPRATPSALAPYYEQKLSWRDCETPGFQCATMKAPLDYAKPGEGDVKLAVSRRK
                     ATGPGERLGSLLVNPGGPGGSAVGYVQKYAGIGYPAKVRARYDMVAVDPRGVAGSEPVE
                     CLTGRQMDTYTQTDLTPDDTEETGRLVAAYKRFAEGCGERAPKLLRHVSTVEAARDMDI
                     LRALLGDEKLTYVGASYGTFLGATYAGLFPERVGRLVLDGALDPSLPARKLNQEQTAGF
                     ETAFQAFARDCVGRKDCVLGRTPAQVAENLRALFERLDARPLATGDADGRRLGESLATT
                     GVIAAMYDEGAWPQLRQALTEAVEKDDGAGLLALSDSYFERAPDGTYSNLMYANAAVNC
                     LDLPAAYDTPEAVERALPEFEKASPVFGRALAWASLNCAYWPVRPTGGPHRIEAKGAAP
                     IVVVGTTRDPATPYRWAESLASQLSSARLLTYDGDGHTAYGRGSDCIDSAINTYLLRGT
                     PPTDGKRCSAS"
     aSDomain        complement(22440..23591)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K1J60_RS19105_Abhydrolase_1.1"
                     /evalue="1.20E-27"
                     /label="K1J60_RS19105_Abhydrolase_1.1"
                     /locus_tag="K1J60_RS19105"
                     /protein_end="498"
                     /protein_start="114"
                     /score="89.0"
                     /tool="antismash"
                     /translation="LLVNPGGPGGSAVGYVQKYAGIGYPAKVRARYDMVAVDPRGVAGS
                     EPVECLTGRQMDTYTQTDLTPDDTEETGRLVAAYKRFAEGCGERAPKLLRHVSTVEAAR
                     DMDILRALLGDEKLTYVGASYGTFLGATYAGLFPERVGRLVLDGALDPSLPARKLNQEQ
                     TAGFETAFQAFARDCVGRKDCVLGRTPAQVAENLRALFERLDARPLATGDADGRRLGES
                     LATTGVIAAMYDEGAWPQLRQALTEAVEKDDGAGLLALSDSYFERAPDGTYSNLMYANA
                     AVNCLDLPAAYDTPEAVERALPEFEKASPVFGRALAWASLNCAYWPVRPTGGPHRIEAK
                     GAAPIVVVGTTRDPATPYRWAESLASQLSSARLLTYDGDGHTAY"
     gene            complement(24148..25353)
                     /locus_tag="K1J60_RS19110"
                     /old_locus_tag="K1J60_19110"
     CDS             complement(24148..25353)
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674051.1"
                     /locus_tag="K1J60_RS19110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_19110"
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="WP_220647260.1"
                     /transl_table=11
                     /translation="MAVWDDLVGQERLSAQLDAAARDADRIVTAAEQGTAPPEASKMTH
                     AWLFTGPPGSGRVTAARAFAAALQCVSPDRALGGSPGCGFCDGCHTALVGTHADVSTVA
                     AVGTQILADDMRDTVRKSFTSPANGRWQVILVEDAERLNEKSANAVLKAVEEPAPRTVW
                     MLCAPSLEDVLPTIRSRCRHVGLLTPSVDAVADMLVRREGIEPEAAAVAARATQGHIER
                     ARRLATDPRARERRAAVLKLPLRVEDIGGCLKAAQELVDAASEESKQLAEEVDTKETEE
                     LKAALGAVQGGRMPRGTAGVMKDLEDKQKRRRTRAQRDSLDLALTELTGFYRDVLALQL
                     GSRVALSNVEVRDSLERLARGGTPEATLRRIDAVAACREALDRNVAPLLAVEAMTMALR
                     AG"
     misc_feature    complement(25973..25992)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 25.23"
                     /tool="antismash"
     misc_feature    27441..27454
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    27681..27696
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.84"
                     /tool="antismash"
ORIGIN
        1 gccgaggtcg agggcggggg cgaggggcgg gtcgtaccgg tcgcgccggg ggcggtcgag
       61 ccagtgctcg atgccctgca ccgtgccgag ccgggcgccg agcagttgcg gggacggccg
      121 gaagtagtcg gagggttcgg gcgggtcgtt cttgccgcgc agggcgcgga tctcccgcag
      181 ggcgccgcgc agttggccgg ccatctcgcg ggcatcggcg aagcgcagac ccggatcggt
      241 gcgtgtggcg cggtcgatga cctcgcgaaa ggaggcggtg ccgaggccgg gcacctcgtc
      301 gacggcccag ccggcgagtt cccgcagggt gacgccgacc gtgtgcaggt cgtgggcggt
      361 ggtgggcatg ggcgaggacg ccgtctcggg tgccatgtag tcgggggtga catgggcggg
      421 cggctgctcc tggccctgtt cgcgcatgcc gccgaggtcg atgaccttga cgccgtcgcc
      481 gtggtgcacc acgttcgagg gcttcatgtc cccgtacacg aagcccttct caccaccggc
      541 gtgcagatgc acgaacgctt cgaggatctg gcagccgtac gcggccacgt gctcgatgtc
      601 gaggacggac tccccgcgtc gggtctcctt gacgaccttg tcgagggtgc cgtcgccgac
      661 gtcgtccatg acgatgtacc cgccggtgac ccgcccggag tcgtcgcgcc gggcgacgaa
      721 gtcgcggatc tggacgatac gggggtggcg gatggcgacg aggttgcggc gttcgaggtc
      781 ggcgagcctg gccccgtcct gctcgtaccg gttgagcagc cctttcacgg cgaccacgtc
      841 gccgaggtgc gtgtcctcgg cgaggtacac ccagccctgg ccgccgtgcg cgatgggccc
      901 catgatccgg tactggtcgc gcagcacgtc gccctcggcg agttcgggcc ggtacgagta
      961 gggctcgccg caggccgggc agtacccctc gaccggcacc gggcccaccg tgtagggcgg
     1021 cgcgaaggtg atgccgcact cggcggacga gcagaccata cggacacgca gcggtgcctc
     1081 gggatggatg agccgttcct gggcgggccg cgacgcccgc tcgggcaacg cgagcaactc
     1141 ggcgggcccg aactcccgcg gctcctcggg cagtgcgggc agccgggggc cgccctccgc
     1201 acgcccgcac acggcgcagt acccggtggg caacagggtc ccgccacacg gcgcaccggt
     1261 gaaccgccga tgcggacaac cgcgcgcccc gagcccctcc gcccctgatc cacccacacc
     1321 cggacccccc gcacccgggc cgcccgaacc acccgtcccg gaggcacctc gggtggtctc
     1381 ccgggcgcct gcgccttggc cgtgcgtccc cgcgccagcc acacgtcggc caccctccgc
     1441 accacgcgtc tccaggccac gcacccccgg accacccgca cccgagccac ccacccctgg
     1501 accacccgcc accgagccac ccaccccggg ggcccgcacg cctaggccat gcactcccgg
     1561 accacccaca cctcgggcag ccgccgggcc gtacacctcc gagccacccg ccgccgagcc
     1621 acgcatctcc ggaccacccg ccccagcgcc ccgcgcgcct tggccatacg cccccgggcc
     1681 accctcacct cgggcagccg ccgggcccgg cacaccttgg ccatgcgtcc ccagcagccc
     1741 atgcatccct cggccggcgg tcgggtcacc cgccccacgg cctcccgtcc ccgggccact
     1801 cctccctcgg cctcccgtcc ccggcccgaa gcgggcggtg aacctcatgt gaggcctccg
     1861 gaaggccagt cgccggaagg ccggtcaccg gacacccggt ctccggtggg ccacccgccg
     1921 gctgcccgct ccccgctggg ccgcgctccg tccgcgcgcc cgccagatgc ccgctttccg
     1981 gtgggccgcc ctccagctga ccacccaccc gatgcccgct ctccgggagg ctcccctcca
     2041 ggtgcctgct ccgcgacggg ccgctcccca cccgcccgct ccccgatgcg ccgcagatcc
     2101 gcgcggaggg tacgaatcaa ctcccgcagc cgggccagcc gttgctgcgg gtccatgccc
     2161 ccaccggcac caccgaaccc atgagccccg cggcctacac gatccctctg ggtcccaccg
     2221 gccctgccga ccccaccacc cccgtcaaac ccacgacccc cgtcaaaccc gccaccctca
     2281 ccaaacccac cactcccccc actcccactc ccactcccac tccccccagt ccccccagcc
     2341 gcgtcgatcg accgccgctc gccccggcgc cgttcggccg tctcggtgag ggagccgagg
     2401 gaggcgctgt cgacgacacc gtgccggacc gcgcggctga actccgcccg ttccagccgg
     2461 gcgaggagcg cgtccgcgtg gtcgaggagc gcgggcgcga ggaggtcgtc gcgggcggcc
     2521 gtccagccgg tgcccccctc ctgccggaag accagcagca gccggaagcc gagcgaccgt
     2581 aatcgggcga ggagcgcgat caaggcaccc ggctcgggct cctcgtcgag cccgtcgacc
     2641 acgacggtga cccgccgccc acccacgagg gcgggtggtc gccccggcgg cggccgggtg
     2701 ccgagaagcc agtcccagta cgccagatac cgtccgggcg gaaaggcgat gtgtcccagc
     2761 gcgtgatcgg cgaggtcggg ccgactggac ccaccacccc ggtagacgag atcggcccgg
     2821 tgcacgagat gccgcaggga ccgttccttc ccgctccccg gaggcaccac ggtgaccttc
     2881 accggctcct cgtcggcgca ctcgtcgccg aaccaccgtg tcagccgctc ctcgaagtcg
     2941 tggtcccagg cgtgggggcc gcacaactca gcgatcacgg gcgacagttc ggcgatacgc
     3001 gcgacgggga tcagatacga gaaggcgagc cggttgttct cgggcaacag ctcgcccatg
     3061 tctccccgcc aactgacgac gagcccgacg acccgggcgg cccgcccctc ctccggccgg
     3121 gtgcacacgg cggccccgct gaacccccgg cgcaccacct cggccttggt gacggcgtcg
     3181 agctgcaccc gctcaccgct gaccccaccg atacgccccc acaggctcat cccgtcgtcg
     3241 aagccctccg cgtacccggt ggcggacacc tccatcccgc cccacagccg ggtctccagc
     3301 cgggcgggcc gcgcctgagg ccgggggctg tccagccgca gtacggcgac atcctcgccg
     3361 accacgtcgc cgaccggctc gccgaccgcc tggcctacgc gccctccgcc gacgtcgctc
     3421 cccgcgagcc aaccgccggg caggacgcgc gcggagaccg gttcgagctc gctgttctcc
     3481 gcgaactcca cccacatcac ggcatccggg tgccgcacca catgggcgca ggtcaacacg
     3541 gtgttctgat cgacgagcac cccggcgccg cagatggggc cccgcgcact cccgcgccgc
     3601 agccggagtc tccagtccgc acgcaattcc cccatgctgc ctcacactac gcgcggggca
     3661 ggccgcgtcc ctagacttgt gaaccaactt ggatcggtca atcaacggaa tccgacgggg
     3721 tgttgacatg agcgataccg aaccggtcgg cctcgccgag gccatcggca cggtccgcgc
     3781 ggaactggcc cgagcccagg ccgagggcgc ggcgagcgac tggcggttca gcgtggagca
     3841 ggtcagcctg gagttcgcgg tccagttcca ccgctccggc gagggcggcg cgggcctccg
     3901 cctcggcgtc gtcgaggccc gcctcggcgg caccgtcagc cacgactcca cccaccgcat
     3961 ccaggtggac ctcaaacccc tcccgggccc gacgggccac caccacgagg tgggccgctg
     4021 agccggccga accccctgcg ccgtgccccg cccgtacctc gtcccgcgtc gtccggccga
     4081 aggtcaatat cgccgcacgc cccaccgggc ccggaacacc ttgagagact gcggccatga
     4141 tcagtgatct tttagcggac aaggtggtcc tcatcaccgg tgcgagcagc ggcatcggcg
     4201 ccgcggcggc gaaggtgttc agccgggagg gcgcggtggt ggtgctggcc gctcgtcggg
     4261 aggaccgact ggcagcgctc gtgagtgaac tgcgggacaa gggggccgag gcgtcgtacg
     4321 tggtgggcga catgtcggtg agcgccgacg cgggccgcgc ggtggacttc gccgtcgccg
     4381 agtacgggcg actggacggg gcgttcaaca acgccgggat cggcggcgac cgcactccgc
     4441 tgcatctgat gacggacgac gtgtacgaca ccatcatgga cgtcaacgtg cggagcgtct
     4501 ggaactgcct gcggcacgag ataaccgcga tgctggcgca cgggggcggc gcgatcgtca
     4561 acaacagcag cgtggccggt gtggtggcca tccccgccgc cgcgccgtac atcgcctcga
     4621 agcacgcggt ggtcggcctg accagggcgg ccgcggacga gtacgcgacg cggggcatca
     4681 gggtgaacgc ggtcgcgccg ggcaccacgc gcagtgagat caccgtggac tggttcgccc
     4741 gcaaccccgg tctggaggag cgggtcaact cgctgacgcc gcagggacgt accgccgagc
     4801 cggaggagat agccgaggcc gcggcctggc tgctcagcga ccgctgcccc ttcctgacgg
     4861 gcgctgtagt gccggtcgac ggagggttcg tcaatcactg acgacagcca ccgacgacag
     4921 ccaccgacga catggccggc gtcgccgagg gcgaccgcag gcggcggggt ccgccgcctg
     4981 cggtgcgcca tgccgccggg ttacgtcagg agccctcgca ggcgcgcctg gaaggcgacc
     5041 tctccgccct ggcgtccggt gacgacgacg gcacaccagt cgggcagcag ggtgggcagg
     5101 cgccgggcct cgatccagca gggctcgtcg aactccacgt accgctcgta gccgatggat
     5161 atgtcggtga gttcgacggg cgtcgggccc gcggcggcgt gggcggcctg atgcgcggcc
     5221 tccagcagga cgagaccggg gacgtggtcg acggggtggt cgaagagcaa ggtgtgggag
     5281 acgtcgttgc gcagttgcca ctggtggtcg gctggtccgg ccgccagcag cacgtcgctg
     5341 tcgtcggccc tgccgaccag gtggctgtcg atgggctccg gcacgggcca ctcgccccat
     5401 gcgacggtga ggtgcgggcc gcgcacccgg cggtaggccg ccggggagac ccagccgaac
     5461 tccgtgtccg cgaggcacac ggtggcaccg tcccgccgga tgcggaactc catgcccagg
     5521 ctcgcggagc gtctgccgga tcgggtgacc gcgatgtcga cctcgaagtc cgaggcctcc
     5581 cgagcctgga atccggcctc ggccgtgatg cggaggttgc tcagcagcgt ctggtgcccg
     5641 gtcggcaccc cgtactcggc gtgcgcgacg aggagtccgc tctgccggat ggtctgcgcc
     5701 aggagccgag ggtcgtaccg gccggggccg cggtacccgg gccagcgggc cgcgacggtg
     5761 aaggtgtccg gtcctgtccg acgccagtct ctgacgacga tcgccgagtc atgtctgaga
     5821 tgcgtgtatt cgcccagtct cgccatgtcc acagcgccat ggagcgcggg ctgcacggca
     5881 ccgatggcgc cgaccaccgt ttccccttgt tgcaatgtct ccacaggcgc cgagcccgcc
     5941 cacgtggggt gcgctgataa agtaacgagc attcggttac tcatgggtga tccttcggtg
     6001 agtgccgatc gactgatcta acggaccgct ggaaggtgtc gggtggtgag gcaggatcgt
     6061 gcgattcgca ctcgcaatct aatcctggag agcatggcga gcttgttcaa tgaggtgggg
     6121 tacgacgcgg cgacgatcgc cgcgctggtc gagcggacgg gactgacccg aggggccctg
     6181 tacttccact tcgcgtcgaa agaggacatg gcgcgtgccg tgctggacga ggccgtgacc
     6241 cgcgaagggt tcagccccca ggcgttcaaa atgcaggagt gggtggatct gggactgctg
     6301 ctggcccacc ggctacccag ggaaccgata ctgcgcgccg cgatccgact ggccgtcgac
     6361 cccaaggcac gcagactctt cggcacccga tggccggact gggtcaccct cggacacaca
     6421 ctgctgaccg aggccaagga gagcggagaa ctattcggtc acgccgaccc cgccgccata
     6481 tcgcgagcgt tcgtcggcgc gtggaccggc gtgcaactgg tgacggaagc cctggaggag
     6541 aagctggacc tctccgagga gatcgcgggc ctgtatcagc tactgcttcc cagcatcgtc
     6601 accccggcgg tgctggccag actcgacctg tcgccccacc gggcggaacg gctcctgcgg
     6661 gagagccgcg gacaggaagc gcccgaacac gagtgagagt cggacgaccc cgatggacgg
     6721 ctccgggtgg acacccggag ccgttgcgcg tccaagcctc gcttcatttg cattagcgta
     6781 cccccgcacc gcggcgtgac gacaagtcgc acgccaagct tcacccatct gcggccatga
     6841 gcgcgctgtc acgcctccgg ccacccggac cccccggttg ggctctgtcg agcgagtgta
     6901 cgcctccaga gtcctgtttt cgagtgccag atatgagtga tatttcggat ttcttgcgcc
     6961 ctccggctcc atgtgacgta agagtttgac cgtttcgcca tagttcatac cgatatgacg
     7021 ctggcggttc actgtacaaa taacaggacg tgtgttcttt tattgatggg aagtttggcg
     7081 tgtaaggagg gggagcgatg gcagtgcacg ctgcgcaacc ggacacgact cgcgtgctga
     7141 tagtcggcga cgacgccgac gccgccgagg cgagggcgcg cgagctgcgc cgacaggggt
     7201 accacgccca gagcgtcgtc accggagcag aggcgctcaa cgcccatcag caggcggacc
     7261 tggtcctgct cgacctcgat cttcccgaca tcgacggtct cgaggtctgt cggtcgatac
     7321 ggcaggccgg cgacaagccc atcatctccg tcaccgcccg caacaccgaa ctggaccggg
     7381 tcctcgccct gcaggccggc gcggacgact gcgtggtcac ctcgtgcggt gagcgcgaga
     7441 tgctggcgcg catcgaagcc gtactgcgcc gggcccgccc gcggacggag cggtcccggc
     7501 ccctctgcct cggcccgctg cacatcgaca gcagaacgcg cgaggtccgc ctgcacgacc
     7561 gcccggtgaa cgtcaccgcc aaagaattcg aattactgca caccctggcc gccacacccg
     7621 aaagcgtcat ttcccgaaag gaactgatgg cacgggtctg ggaaaccggg tgggcggact
     7681 ccagccgcac catcgacacg cacgtgcgca gcctgcgggc gaaactcggc acgcattcgt
     7741 ggatcatcac ggtccgcggc gtcggttacc gcatgggaca cggctgacga attccgtgag
     7801 aacgccaccg cgggtccgaa ccccgaaagg aattcggacc cgcgccggcg cgatcgatcc
     7861 gtcggtattc ggttacgtca cctacgtcac ggccccctgc gcgtacggcg atccgtcgag
     7921 cccggccggg tcctggccga ggccggccgg ggtcacccag tcgaaggcgc tgtagaccgc
     7981 ggggccgagg ccgatgttct cggcgacctg ctcccgcaac cggttggagg tgaagccgcc
     8041 gatgacgttc atctgggcgt cgcggtagag gcgttccacc tcatggccct gggtgacgcc
     8101 ggtcgccccg tggatctgca cggcccgggc ggcgacctcg acgcccatct cggtggcgta
     8161 gatcttgagc atcgcgatca gatcccggac cgagcggcct tcgacgcgcg cgcacatcgc
     8221 ccggcgggcc agcaaccggg cggcgtcgat ctgggcgcgg gactcggcga gctgcgcctg
     8281 cacaccctcc atgtgcgcca gcggccgacc gaacgagacc cgctccctgg catgccgtac
     8341 cgaggcggcc agggcggact cggcgacggc gatggccgcg aacgagttct tcagccagcc
     8401 ccatgccatg ccctcggcga gctccccgaa cggcaccggc accacatcgc tcgcggcgat
     8461 gtgggcgtcg gtgaagacga tcccgcccca cggcatgccc cgcagcccca tgtgcgcgat
     8521 ctcgtaccgc tcgacgccgg gttggttcag gtcgacgaag gcgaggcacc agtcggggcc
     8581 gtcgtctccg gggagccgct ccctgcgggc gagtaccacg gccacgtcgg cgacgggcgc
     8641 gttggtgatc ctggacttct ctccgttgat gacgaacccg ccctcgggct cccgggcggg
     8701 ccgcaccgtg gtccggtagg tgccggcgtc gctgcccgcc gtacgctcca ccacggcgaa
     8761 ggcggccagc cgctccccgg acagcagggc ccgcagcagc ggctcgtggt gtcggaggtc
     8821 gccgtaggtg gagatcagct tgccgcacag cagcgtggac acggtcgccg cccagtaggt
     8881 gccggggcag gcccgcgcca gcgcctccat ggcatcggcc tgggtgagtc cgtcggcgcc
     8941 ggtgccgccg atctccggcg ggtggaacag ccgcaggtag ccgctgtcgg cgagctcctt
     9001 ccagttctgg gccggtatgc gacccgtcgc gtccgtctct gcggctcgtg cggcgatgcc
     9061 ggggaaggcg gggaagtcgg ggaagtcggg cacggcccgg ttcccgctca cgtagtccgc
     9121 atgcgtggtg ctggtcatct cgtacgcgct cctcgggttg acctcgtgtc gggcatgttc
     9181 agccgagttc cagcagggac gccgctatca ccgggcgcag cacctccgtg ccgcccccgg
     9241 tgccggcgaa gaacagcccg tcccggtgcg cccgtccgac caggtggtcg ccggagaggc
     9301 cgagcgggcc ggacaagcgc acggccgcgt ccgtgaccgt gcgcacggcg gcggccacga
     9361 agagccgggc ggccgccgcg tcctggtgtg agggccggtc gccggagtcg aactgctcag
     9421 cggcccggta cagcattccc tcggcgagtt cgcagcgcgc ggccagatcc gccagggtga
     9481 accggacgga ctggtcgtgg tggagcggcc gtccgaagag ccgtcgttcg cgggcgccgt
     9541 cgacggcgtc ccgggtcagg gcacggatga ggccgagcca gggggcgctg gagaagaccc
     9601 agtccagcac ggccagcagc ggctccacct cggtcgccgc gccgccgacc gagcccagca
     9661 ccgcggtgtc cgcgaccgcg cggccgtcca ggaccaaccg gccccagggg caggtgggca
     9721 tcgcggccgg gcgggcctcg tccacccaca gcctctcgcc ggcccggtcc acgacgaacg
     9781 ccgtccgtcg gccgtcgtcg tgcgcggcga cgaccaggaa gtgatgggcc acgggggcac
     9841 cggcgaccag gtccagttcg ccggtgagca cccagccgcc cgccccctcc gcggcgggcc
     9901 ggacggtgac ggtgggggcg agggacgccc cctgggtctg ctggagcgac agcgcgccca
     9961 cccactcgcc cgacgccatc cggggcaggt accgctcccg ctgcccgggg gtgccgaagg
    10021 cgcgcagggg cacggtggcg agcaccgcgt gcactgcgac cgcgagggcg aggcccgggt
    10081 cgcgcgcccc ttcaccgagc cccgccagca ggtcgacggc ctcggtggcc gacaggccgg
    10141 cgccgcccag gtcgggcggt accaagggac cggcgaggcc cgggccgggc cgggcggcga
    10201 ccagctcggc gaagagccgc gggtcccagc ggcactcgcg gtcgcgttcg gcggtggtcg
    10261 gtcccgcgag gcggtcggcg agctcccggg cccactcgcc tgtggggaaa tgcggaattc
    10321 ccatcgaagt ctccactccc atccactgaa aacgggcccg gtcaccataa ccagcaattc
    10381 gaacaattct cggtgcggat ttgagatttt tcagcgatcc tgcggacagt tcacagaaat
    10441 gactcgcgcg gacttttcag cacagtcctt gacaatgctc tgacacaaga gccgttgtct
    10501 cctcacattg cgccgtccac catggttggc ggccctgcaa aaggaggaag agcaatggca
    10561 gtagcagagc acgggggaag tcttccgagg ctgccccatc tgtctgacgc gaccctgcgg
    10621 gactccgcgc acatggccgg cgtcgagttc ggccccaagg acgccgcggt catcgcggac
    10681 ctgctggtga agaccgggat cgagctcgtc gaggtcggca tggtgtccgg tccgggctcc
    10741 aaggacgccg atctggtcct cgccacccat gaggccgtcg gcccggaacg cagcatgacg
    10801 ctcgtcgtgg tgcgggaccg ccagcaggtc gcgaaggccc tcgacgaggc cgagcgcctg
    10861 ggcgtacggc acatcatgta ctccatcccc acctccgagc agcacgcgaa gctcaagctc
    10921 ggctcgccca gcgccaagtt cctgcagacg ctggcccgtt cggcgatcac gcaggccaag
    10981 gaacgtggct tccacgtcac cttcagcggc gaggacggcg cccgtacgcc cagggaacgc
    11041 ctcgtcccct atgtcaccgc cggcttcgag gcgggggccg acaggttccg gctcgcggaa
    11101 accgtcgcct acctgtcgcc ctggcagatg gaggaggtca tcgccgacct caccgcgatc
    11161 gacggctccg agatcgagat ccactcgcac aacatgctcg gcatggccgt cgccaactcc
    11221 ctggccgccg tccgcgcggg cgcgcagtgg atctcggcga ccgtcggcgg catcggcgaa
    11281 cgcggtggca acgccccgct cgccgaactg ctcacctcac tgcgtgtcat ccacggcgac
    11341 acccgcttcg acctgagcca cctcaccgag ctgtcgcggg tcgccctcaa gggcgccggc
    11401 ctcggcgact ccttccagtc gggaccgacc acaccgcacg cgttcgccta tgaactgccg
    11461 ggccagctca cccacccgga ggcgtacgag acgctgcccg ccgaactcgt cggcaacgcc
    11521 cgcgagctgc gggtccgtac gcgcctcacc cctgccctcg tcaagtgggc cctggccgaa
    11581 tcgggtgtgt ccgtcgacat cgacgccttc accccgtggc tcatcgagcg gcaggagcgc
    11641 gacggaggcc cgctgctcga ccgggacacg atccgcaagg ccgccatcga cttccaggcc
    11701 gcctgaaccc acgccctcac cggggcaggc cggtccgtgc caccccgatc ccgtacgacg
    11761 aatccggagt tgatccatgt ccaccgccct cctcaccggc gactgccccg agtgcgaaac
    11821 cgacctgacc gtgcccccga tggttcaggg cgagaccctc tcctgccccg agtgcatgct
    11881 cacgctgcgc gtggaggaga tccagaacgg ccggctgtcc ctgcagatgg tcgaggtaca
    11941 gctgcgcgac tggggccagt gacatgcccc tgaacgtcgc catcgtcgcg gaccgggtcg
    12001 gctgggagga acgcgaactc atccgtcgcg ccccggacct cggtctccgg atcgactggg
    12061 tcaacgacga gtccctgtgc ctcggggaca ccaaggcccc gtcgatcgac ggctacgacg
    12121 ccctgttggt ccgcagccgc agctacaccc gcggcgggct gctcgccacg ctggccgagt
    12181 cgggcggtgt gcccgtcctc aactccgcgg gggccatcca cgcctgcgag aacaagctgg
    12241 tgctgcgctc cgagctgcgc tccgcgggcg tgccggtgcc ggacttccgg ctcgccctgt
    12301 cccgcaagga cttcactcgg gcactcgacg acctgggcct gcccgtggtg ctcaagccgg
    12361 tctacggcgg catgggcaag cgcgtcaccc tggtccgcga ggccgacctg gcgcagtccg
    12421 tgtacgacta cgtcgaggac ctcggacacg ccttcgagca ggcctgtctg gtggagccgt
    12481 atctgggcgg cggctcggtc cgcgctctgg tcgtcggccg acgaatcgtc gccgccgccg
    12541 agttcgagag tgccggagcc gactggcgca gcaacgcggc gctcggcaac cagagccggg
    12601 ccctcgccca tgaccccgag gtgcagaagc tcgtcgacgg ggtcgtggac cgactcggcg
    12661 agggcatcta cggagtcgat ctcttcaaga cgccatcggg ccacgtcgtc aacgaggtca
    12721 accacgcccc cgcctggcgt ggggtggcat cgacgacggg ggcggacatc ccgtcggcca
    12781 tcgcccgtca cctgcaggag acatacgcat gatccgcgtg ggaatcgtcg gcgcctccgg
    12841 gctcaccggc ggtgaactga tcaggctggt gagccagcat cccgaactcg aactgacctt
    12901 cctcggcggc aactccagcg ccggccggcg cccggcccag ctgcatcccg ggctccgcct
    12961 cgacctgggc ctgaccgtcg agcgcgtcac ggcggaggcc gtggccgagc ggtgtgacgt
    13021 ggtgttcctc gccacgccgg ccccggcctc ggccgaactc gccgcgctcc tcgccgaccg
    13081 cgtcccgtgc gtggtcgacc tgagcggcgc cttccgtatc cgcacccctc ggctgcatga
    13141 gcgctggtac cccaaggcca cccggtcgga cgaactcgcc gaccgcttcg tctacggcgt
    13201 accggaactc gtcggcgacc agctggccgg cgccccgctg atctccgtac ccggttgtta
    13261 cgccacggcg atcaccctcg ggctcgcccc gctgaccctc ggcctcggcc tgaacctgaa
    13321 gaccgtggtc gtggacggca agagcgggtc cagcggcggc ggcctgcagc tgcgcgtgcc
    13381 ggacctgcac ccgctgcgca acggcgcgat cgcaccgtac gcccccacgg ggcaccggca
    13441 cgccgccgag gtcggcgact tcctggaaca cagcaagccc ggcaccgtcg gttcgctgac
    13501 gatgtcggcg tacggggtgt cgcacgtgcg cggactgctc gccagcacct acgtcttcac
    13561 cgacgacgag gtggacggcc gcgaactcca gcgggcttac ctgcgcttct acaaggggca
    13621 ccggttcgtg cgggtgcggc ggcacaccga gacgctcatc ccggtgcccg atccgcaggc
    13681 ggtcctgggc tccaacttct gtgatgtgac ggtcctgtac gacgacgaag gcggccggat
    13741 cgtcgtcctc gccgccctcg acaacctcgt caagggcgcg gcgggccagg ccctccagtc
    13801 catgaacatc cggttcggcc tgccggagga gaccggcctg acgatgcagc cggtgatgcc
    13861 cgcatgagcg agacgatcac acagcggacc ccgaccgtgg tgaagctggg cggcagttgc
    13921 ctggacgatc tcgccggcga ctggtgggac gacctggccc ggcacggccg acagcggccg
    13981 ctggtcctgg tgcacggctg gtccaagccg ctcaaacagc tcagcccgcg ccacagcgaa
    14041 ccgtccgcga tcctgcgcga ccggtacggc aatcagagcc gctggaccac gcccgaggtc
    14101 atctcggaca tcaagaccgt cagtctgcgc ctcggcgagg acgtcctcga ccgcctcgaa
    14161 cagcgcggca tcaccgcgga acggctcctg ggcagtgacg gcctcgtctc cgccggagaa
    14221 ggcgagcgct ggtggtggcg gaacaagcag ctggtcgagc tggagaacct ggtcggcccg
    14281 atcaccgggg tggacccgtc ggcgctgaag aacctccagc cggggcacgc ctacctggtc
    14341 actccgctgg ccaggaacgc ggcgggccag gaggtcaaca ccgacgccga ccgggccgcc
    14401 gccgccgtcg cgggcgccac cggcgccgag gacctggtgc tcgtcaccga tgtcgcccat
    14461 ctgctgatcg acggcgagcc ggtgcgacgg atcacggcgc gggccgccgc cgagttccgc
    14521 gacaagggcg ccaccggagg catgcgcaag aagctgcgcg ccgccggcga ggccctggag
    14581 cagggcgtgg agcgcgtcgt catcggcagc gcgccggtca ccgagctgct cgccgcccgc
    14641 accggcaccg tcatcacccg aacgtgagga gcatgcgcgt ggcgcagtcc cgagtactcg
    14701 tcgtcaacaa cggaacgctg tcgctgaagc agctccgcaa gcgtttcgag caactcggct
    14761 cggagaccga ggcggtcgac gcggcctccg tgccgaaccg gctcgacggc cgctatcagg
    14821 cgatcgtgct gagcggcacc aaggtgcggg cctacgaccg cgactactac aagccgctca
    14881 tcgacctcgt catgagcgcc gacgtgccgg tcttcgggat ctgcggcggc atgcagatcc
    14941 tcgcggtcgc ggcgggcggc cgactcgccg aggggcccca gcgggtcggc ggctacgagg
    15001 tccaggtcga caaggaggaa ccgctcttca cccatgtgaa gccgacggtg accgtcttcc
    15061 accggcacac cctctacctc caggaggcgc cccccggttt ccgctccatc ggccggtccg
    15121 agcacgcgcc cgtggagttc ctgcgctccg acgacggccg gatcctcggc tcgcaggcgc
    15181 acctggagtt ccgcggggac ggcctggaga tcctgcgcgg attcgcccag ctctaccagt
    15241 gacccacatc tacgtagcga ggattggcaa tgagtgatct ggaaaccccg cacgaccccg
    15301 cattcacggt gcacctgaac ggcagcggcg gcgcgctcag gggctgggtc gtcgtcgact
    15361 ccctctacga cggcctggcc atgggcggcg tacggatgac cacgggggtc accgaggagg
    15421 aggtcgccgg tctcgcccgc gacatgacgc acaagttcat cctcgccggc ctgcccatcg
    15481 gcggcgccaa gggcggcatc gtctccgacg gcaccgaccg cgaggagacc ttccgcacct
    15541 tcggccgcac cgtcaaaccg ctgctgcacg gcgggatcca cctcggcatc gacatgggtg
    15601 tcacccctgc cgaccgcgcc gtgttcttcg ccgaggccgg ctacgacccc cgctaccggt
    15661 tgggcgcacc cgacatgccg atcgactggc ggacgtacta cgagcccctg atcgactgca
    15721 ccggccacgg ggtcggggtg gcagcggtca ccgccctgga ggcgaacggt cgtaccggtc
    15781 ccgcccggat cgtcgttcag ggattcggag cggtgggccg ggcggtcgcc cggttcctgg
    15841 aggagcgcgg gcacgtgatc gtcggcgtgg ccgatgtgca cggcaccgtc agcgcggacc
    15901 ggctgccggt ggccgacctg atcgccgtca ccgacgagtt cgggctgatc gaccgttccc
    15961 ggctgcccca ggacgtcacc tgctccaccg agccggacgc ctggctcgac gtcgacgccg
    16021 acctgctggt cctcgccgcg cagaagaacg cgctgaacgc cgacaacgcg caccggctgc
    16081 gggcccacct ggtggtcgag ggcgcgaacc tggcttccag cgccgaggct cgggagaagg
    16141 cgcgggcctc gggcgccact ctggtaccgg gcgtgatcgc caacatcggc ggggccggct
    16201 cggccgccct cgccgtcacc cgggtcgtcc ccttcgatct ggcggccgag gcccgcaagg
    16261 catgggtctt cgactggatc ggcgaccgcg tgcgccgcaa cacccgcgac ctgctggaca
    16321 tcggcgccgc gaaccccggc gacccgctgc ccgaactgct ggagacccgc cgcaaggagc
    16381 ggggatgacc tcgacgacca cagccatcct ggccacggcg tcggccgcgg accgcatggc
    16441 ggagtaccgg cggcgcggct ggtggcgcga cgagaccttc ctcgacgacc tgcgtcgcca
    16501 ggcccgggaa cggccgcgca agctggccgt cgccggacgc cgtctggacg aggcccgcac
    16561 cgacaccctc gactacgccg aactggcgcg gctgaccgac cggttcgccg gggcgctgct
    16621 cgaactggac gtgcgacgcg gcgacgtggt cgccgtccag ctgcccaacc ggtgggagat
    16681 ggtgccgctg atgttcgcct gcatggcggt cggcgcggtc atctgcccga tcgctccggt
    16741 ctgccgggag gaggaactgc gccaccgact ggcgctcacc gaggcgaagg tgtgcgtgac
    16801 ggtgccggaa tgggagggct ttccgctcgc cgagaccgtc accgcgctca aggaggaact
    16861 tcccctcgac cacgtcgtgg tcgtcgacgg gcacgctccc gaaggggccc tcgacttcca
    16921 cgaccacttc gtggccaccc cctgggagaa gcggcgcacg gccgacctgg agggccgtca
    16981 gctgcggccc gacgagccgt tcgtggtgct gttcacctcc ggcacgaccg gcttctccaa
    17041 gggagtcgtg cacagccaga acacggtgca ctcgggtgtg cgcggctatg tggacacctt
    17101 catgctccgc gacgacctgg tggtcgtcgt caccaccccg ctggtgcact actcgggcct
    17161 cgggcagggc gtcctcgccg gggtgatgct cggcggaacg gtcgtcttcc aggacggcgg
    17221 ggaccacacc ggcctgctgg acctggtcga gcggtacggc gccaccctgc tgtacggtcc
    17281 gccgcccacg ctctccggtg tggccagggc ccagcggatc gatccgcacg acgtgtccag
    17341 tctgcgccat acggtcaccg gcgccgctcc ggtgctccag ccgctggtgg acgaactgcg
    17401 ccagaccttc ggagcccgca cgtattcggt gtggggcatg tcggagttcg gtcccgtcac
    17461 catcagccgg ctcgactaca accaggactg ggcggcgcac agccacgggc ggcccatcga
    17521 ctcgatggag atccgcatcg acctgtgcca cgacccctcg aagcgggccc cggtgggccg
    17581 gctgcgggct cgcggcgcgt cgcgggctct cggctactac aagcaccagg acgccttcga
    17641 cgccgaactc accgaggacg gctggttcga caccggcgac gtggcgcgtg aggacggccg
    17701 gggcggtatc cgcatcctgg gccgcgccaa ggacaccatc ctgcgtgacg ggatcgtcgt
    17761 accgatggcc gagttggagg cgatcctctc ccggcatccg aaggtgaccg aggccgccct
    17821 cgtcggtccc cacggcacgg tcgacgatcc gatcctcgtg gtcgtcgtcc cgcgcggcga
    17881 cgccaccgtg acgttggagg agatccgcgc ctacctgagg gaggccggcc aggacccccg
    17941 cttctacccg gagcgcctgg agatcgtcac ggccctgccc aagaccctca ccggcaaagt
    18001 ccgcaaggtc gaactgcggg agcgcttcgc cggcgcgtga cctcgccgcc tccctccccg
    18061 ccgtccgggc gtgccccgcc cggccaccca tcagccccgc tcgattcgtt ggagcccacc
    18121 atgaccgcac gcgtgcccgt caccatgtcg gcgaccctcg ccgccgacga ggcgctggct
    18181 cgacggcagc gtgccgggga gcaggtgctc tccctggcca gcggggagat cggcctgccc
    18241 gtgctgccgg cgttgcggga gcggctcgcc gcggcggcgg atcgcaacgc ctacgggtcc
    18301 gtggccggga gcccgaggct gcggtccgcg gtcgccggct actgggggcg gcggaacctc
    18361 tccgtcgatc cgggcctggt ggtctgcgga ccgggcagca agccactgct gttcgccctg
    18421 cttctggcgg tcggcggcga tgtggtggtg ccggtgccga gttgggtgag ctacgcggcg
    18481 caggcccggc tggtcggggc gcggccgatc ccggtgcccg tcctgccggg cgagggcggt
    18541 gtgcccgatc cggcggccct gcgcgaggcg gtggcccgcg cccgtgccgc cggtcgggac
    18601 ccgcggtgcg tggtggtcac cctgcccgac aaccccaccg gcaccgtcgc caccgcgggc
    18661 acggtcgaga gactggcgcg ggccgcccgg gacctggatc tcgtcatcgt ctccgacgag
    18721 atctactgcg acctcgtctt cgacccggcg gaccgcgcgg tctccccggc ggccttcgcg
    18781 ccggagcgga ccgtggtcac cacggggctc accaagaacc tggcgctcgg cggttggcgg
    18841 ctcggggtcg cccggctccc cgacagcccg ctcgggcacg aggcgctcac caggctggtc
    18901 ggcatcgcca gccagatctg gtcgagcacc gcggccccgg tgcagagcgc cgcggcctac
    18961 gccttcgagg agccgcccga ggtggtcggg tacgtcgcag ccgcccggcg actgcacgag
    19021 gtggtggtgc gcgcggtggc cgagcggttc accgccgccg gcgccggact cgccccggtg
    19081 cgggccacct gctacctcta cccggacttc gagccgctcc gggaccacct tgccggggcg
    19141 cacgacgtgc acggcgccga cgccctcgcc accctcctcg cgcaacggta cggagtgggc
    19201 ctgctgccgg gaaccgcctt cggcgaggag gaccgttcgc tgcggatccg ggtcgccacc
    19261 agccgtctgt acggcgggac cgacgccgag cgcttcgcgg cactggccgc cgacgagccg
    19321 gcccgactgc cctgggtcaa ggcctcgttg gaccgcatca ccgaggtcct gaccgacctc
    19381 accaccctct aaggagatcc ctcaccgcca tgtccatcct cttcgaatgc gagtacaagg
    19441 gtcagcggta cgccggcgta ggcgtaccgg cccccggtga cacccatgtc ctgcaccggg
    19501 tgaccgaggg gcaggtacgc gccgccgtca tcgcggcccg cggccccgaa gcggtcctcg
    19561 ccgcggtgac cgagggcgcc gagacggtcg aggtgaccat cggtgacccg gaactgcgct
    19621 tccttcctcc gctgctgccg acgagcacca acaacgccct ggtcaacggc ttcatgggca
    19681 cgcaccgctc caagttcgac cacgacccgt cccccgacga ggagttcacc ccgccgaact
    19741 actaccagaa gggcttcggc tcctggctgc gcatgccgga cgaacccctg atcaccccgg
    19801 cggatccgat ctggctcatc gaggagccgg aggtcgccct ggtctacgtc aacgacgacg
    19861 acggcgtccc gcactacgcc gggtacacct tcggcaacga cctcaacgac atcggcgtgc
    19921 acctgaagaa cccgtgggcc tggacgccgt acgccaagct ctgcgagacc tccctcgcac
    19981 cctggctctt cctcgacgag ccgccgcgga cggtgaccgg ccgggtgacc atcgagcgtg
    20041 acggtgcccc ggcctgggag ggcgacttca gctgcggcgg ggactccctc taccaacgcg
    20101 tcgaggacat gacggcgtac gtcctgtcgc acccgattct gcgacagccg gggctggtca
    20161 actacctgct gctcggcgcc gacaaggcca cctaccacga cggcttccgg atcgaggacg
    20221 gtgaccggat ggtcatcgac gtgagcagcc acggtgtcgt actggccaac cccgtccagt
    20281 acggtcaggc agccacgacc gactcgcggc ggacggcctc gaggtagccg gagatggcct
    20341 ccctgctgcg catcaggcac tcgatgcggt cggtcatgcg ctggcgctcg ccctccaggg
    20401 cggcgatcgt ctccggcgtc gcgtcggaga cgtggatggc ccgggggtcg ttgatgcacg
    20461 gcaggatctg cttgatgatc cgcgtcggca gtccggagtc gaggagtcct ctgatctgca
    20521 ggacccggtt cacacagccc tcgggatagt cccggtagcc gttgggcgcg cggtcggcga
    20581 ccagcaggcc ctgctcctcg tagtagcgca gcagccgacg aggggttccg gtccgctcgg
    20641 acagctcccc gatccgcatg tgacccacct ctttcgtacg agcttgacat tcacaccgat
    20701 gtgagggttt gaggatacaa ccatgtcaac atcccagaca gagctgctga gcgattccgc
    20761 tccagcagca gacaatcgga agctgcccct ctcaccgctt ctggctctgg ccacagcagc
    20821 cttcatgggg attctgaccg aggcgctccc ggcgggtgtg cttcccgaga tggcccgtga
    20881 catgtcggtg agcgagtccg cgatgggcca ggccctgacg gtctacgcca tcgccaccgg
    20941 cgtcgccgcc atccccctgt cggtcaccac ggcggcctgg cgacgcaagc aactgctgtt
    21001 gctggcggtg acggtgttcg cggtcgccaa cctggtcacc gccctctcgt ccaactaccc
    21061 cctgacgatg gtgttccggc tcctcgccgg tgtcgccgcg gccgcggtct gggccgaact
    21121 cgtcggctac gcacggcgtc tggcgccccc gcacctccag ggcagggcca tcgccatcac
    21181 catggccggc gtcccgctgg ccctgtccct gggcatcccg ctcggcactt tcctcggcgg
    21241 gctcttcggc tggcgcatga ccttcggcct cgtgacggtg atctccgtgg cgctgctggg
    21301 gtggatcatg gtgtcggtcc cggacgcccc gggccaacgg ccggaggccc gcgagcccat
    21361 cctgaaggcc ctgtcccttc cgggggtcgc ggcggtcctg ttcgtggtcg cggcctacgt
    21421 gctggcccac aacatcctct acacctacat cgccaccttc ctcgacgcct acgacatggg
    21481 cggctcccgc gacatcgtgc tgctcgtctt cggcatcgcg tccgtggtga gcatctggat
    21541 cacgggcgcc ctggtcgacc gcaagctgcg tcaactgacc atcgtcagca gtgccttgtt
    21601 cctcgtcgcc tccgtcctgc tggcggcgct ggccgggaac atgatcgtgg tctacacggc
    21661 gatggtgctg tggggcctcg gctggggtgg cgtcaccacg ctcctgcaga ccgccgtcac
    21721 cgacgcggga ggcgaccgag gacaggccct gctggtcacc acgtggaact cgttcatggc
    21781 cggcggcggg gcggtcgggg gcatcctcct ggacggcctc ggccccaagt ccttcccgtg
    21841 gagcgttctc gcactgatgg ccccggtcct cctggtggtg atcgccgccc gcaagcacgc
    21901 cttccccacg acccgccccg gaaccgactg acacctcgct cgactgccac ctcgttcaca
    21961 cgaccaccga acgagcctcc cccagaaacg cgtcacgcac gggagtccgt tctcgccatc
    22021 cccccgccgg aacacccccc gcgcgacgcc gaaggaagac cccgtaccca gccatggcgg
    22081 gtacggggtc ttcccacgtc acacaacaca aaagcccagg ccaccactat gggacctggg
    22141 ctttacaaga gccgccttcg ggattcgaac ccgagaccta cgcattacga gtgcgttgct
    22201 ctggccatct gagctaaggc ggcgcgctgt ccgcactatg gtgcgatcag caacgtcggt
    22261 aagtctacac agtttccgcg gtgctccgaa ccacgggtcg gagcaccccg gggacgaccg
    22321 ggcccagacg tcgcagaggt cgatgatcag gacgctgagc agcgctttcc gtcggtcggg
    22381 ggtgtgccgc ggagcaggta ggtgttgatc gcggagtcga tgcagtcgct gccgcggccg
    22441 taggcggtgt gtccgtcgcc gtcgtaggtg aggaggcggg cggaggagag ctgagaggcg
    22501 agggactctg cccagcggta cggcgtggcg ggatcgcgcg tggtaccgac gacgacgatc
    22561 ggggcggcgc ccttcgcctc gatgcggtgc ggcccgcccg tcggcctcac cggccagtac
    22621 gcgcagttca gggaggccca agcgagggcc cggccgaaga cgggcgacgc cttctcgaac
    22681 tcggggaggg cccgttcgac cgcctcgggg gtgtcgtagg cggccgggag gtcgagacag
    22741 ttcacggcgg cgttggcgta catcaggttc gagtaggtgc cgtccggtgc ccgttcgaag
    22801 tagctgtccg agagggcgag caggcccgcg ccgtcgtcct tctcgaccgc ctcggtgagt
    22861 gcctggcgca gctggggcca ggccccctcg tcgtacatcg cggcgatcac gcccgtcgtg
    22921 gcgagggact cgccgagccg ccgcccgtcg gcgtcacctg tcgcgagcgg ccgcgcgtcg
    22981 agccgttcga agagcgcgcg caggttctcg gcgacctgtg ccggcgtacg ccccagcacg
    23041 cagtccttcc gccccacgca gtcccgggcg aaagcctgga aggccgtctc gaagcccgcc
    23101 gtctgctcct ggttgagctt gcgggcgggc agcgacgggt ccagcgcgcc gtccagcacc
    23161 agtcggccga cccgctcggg gaacagcccc gcgtacgtcg caccgaggaa cgtcccgtac
    23221 gaggcaccta cgtacgtcag cttctcgtcg cccagcaggg cccgcaggat gtccatgtcg
    23281 cgggcggcct cgaccgtgga gacgtgccgc aggagcttgg gcgcccgctc cccgcacccc
    23341 tccgcgaacc gcttgtacgc ggcgaccagc cgacccgtct cctccgtgtc gtccggggtg
    23401 aggtccgtct gcgtgtacgt gtccatctgg cgcccggtga gacattcgac cggctcgctg
    23461 cctgccacgc ccctcgggtc gacggccacc atgtcgtacc gcgcccggac cttggcgggg
    23521 tagccgatgc ccgcgtactt ctgcacatag ccgaccgccg agccgccggg accgcccgga
    23581 ttgaccagca gcgagccgag ccgctccccc gggccggtcg ccttccgccg cgagacggcc
    23641 agtttgacgt cgccctcgcc cggcttcgca tagtcgaggg gcgccttcat cgtggcgcac
    23701 tggaaaccgg gtgtctcgca gtcgcgccag ctcagcttct gctcgtagta cggggccaga
    23761 gccgacggag tcgcacgggg cagcgggccg agggcgggcc ccccgtcgac ggtcgtggcc
    23821 gccgcactgg agtggcctga ggagcagccc gcgacgagca gcgcggcggc agcgagcaac
    23881 gcgccgccgg cccgcaggga ccggtgcggc cgggaagtac gcctggtgtg catctcgcga
    23941 gcgtaaccag aaccgcgcaa ttcatcacga acagcaacga acgctcctcg tacgagtgac
    24001 gcggtcaacc gaacgcaccc ccaccccgca gacagaccgc gcggaccacc ccccacagca
    24061 gaccgtgcag accggccccg gtaaggcaga ccacgcagac cagccgcgca gaccaccacc
    24121 cccgtacccg gcccgccctc cgtcacctca cccggcgcgc agggccatcg tcatcgcctc
    24181 cacggccagc aggggcgcca cgttgcgatc caacgcctct ctgcacgccg cgaccgcgtc
    24241 gatgcgccgc aacgtcgcct cgggcgtgcc tccccgcgcc aaccgctcca ggctgtctcg
    24301 cacctcgaca ttggagagcg ccacccggga gcccagctgc agagccagca cgtcccggta
    24361 gaacccggtg agctcggtca acgcgaggtc gagactgtcc cgctgcgcgc gcgtacgccg
    24421 ccgcttctgc ttgtcctcca ggtccttcat cacgcccgcc gtgccgcgcg gcatacggcc
    24481 gccctgcacc gcgcccagcg ccgccttcag ctcctcggtc tccttggtgt cgacctcttc
    24541 ggccaactgc ttcgactcct ccgaagcggc gtccaccaac tcctgcgccg ccttcagaca
    24601 cccgccgatg tcctcgaccc gcaacggcag cttcagcaca gcggcccgcc gctcccgggc
    24661 ccgcggatcg gtggccagcc gccgggcccg ctcgatgtgc ccctgggtcg cccgcgcggc
    24721 caccgccgcg gcctccggct cgatgccctc ccgccgtacg agcatgtccg ccacggcgtc
    24781 caccgacggt gtgagcagcc cgacatgccg gcaccgcgac cggatcgtcg gcagcacgtc
    24841 ctccaacgag ggcgcgcaca gcatccacac cgtccgcggg gcgggctcct ccacggcctt
    24901 caggaccgcg ttcgccgact tctcgttcag ccgctcggcg tcctcgacca ggatcacctg
    24961 ccagcgcccg ttcgccggcg acgtgaacga cttccgcacc gtgtcccgca tgtcgtcggc
    25021 gaggatctgc gtgcccaccg ccgccacggt gctcacatcc gcgtgcgtcc ccaccagcgc
    25081 cgtatgacac ccgtcacaga acccgcatcc ggggcttccc ccgagcgccc ggtccggact
    25141 cacgcactgc aacgccgcgg cgaacgcccg tgccgccgtc acccgccccg accccggcgg
    25201 ccccgtgaac agccacgcat gcgtcatctt ggacgcctcc ggaggcgcgg tcccctgctc
    25261 cgccgccgtg acgatccggt ccgcgtcccg agcggccgcg tccagctgcg cgctcagccg
    25321 ctcctgcccc accaggtcgt cccacacagc catgccccac cgcctccgtc ccacaacacc
    25381 ctcaccgcgc cccattgtgc gcgaccccac tgacacccag ccccacacgc ggaccgaggg
    25441 cgcgaaaccg ctgcccccgc acgggggcag cggaccggcc gcgagcacgg acacaaggcc
    25501 gcaaaggcac cgctgcgggg cgggcccacg cacagaaggg gccggccggt gcgtcaagcc
    25561 cgtcgcacac ggcggcccag agaccagaga ccccggaggt tcccccctga gcagtggagc
    25621 accaagcgac gggctggcgc accggcacgg ccccgacccg aagaaccacc ggcgtcacgc
    25681 gtaccggcgg tggcgcgcgt accggtcatc cgcaacccat ggcacgcacc ccgccaccgc
    25741 gtctcagccc acctcagcgt cggcgccgcc cccagccccg ccgctcatcg gcgtcgtcct
    25801 cgtcgtgcgg ccccaacaac tcgtccgcca acgtgggcag atcgtccaac ggcgtctcct
    25861 cggcccagtc cgaccgaggc cggcgccgcg gcactccctg ctcgtcgacc tgcggcagct
    25921 cccgcgtccg atccacggcg tccgacccgt cgaccgcgtc cgacccgtcc gccgcgggcc
    25981 gctcgtcccg gaagtatccc ggcggcaccc gatcgtcccg caccggcggc aggacagccg
    26041 tctcatcggt cgtacccgag ggcacctgcg gcaacagcgc ggtctcatcc tccgcagcgg
    26101 cccccgcgga cggcaccgac ggcttcggca acttcgccgt cgtctcggag tcggcgcccg
    26161 acgcgtcccc ccgcaccggc ggcaagacag ccgtctcgtc caccggccca cccgacgcat
    26221 tcgtcggcgt caccaacggc gtggccacgg tcaccgcgtc atcgccatga ccaccggcac
    26281 cggcaccggc accggcaccg gattcagccc cggccccccg ctcggccgcg acccgcgcag
    26341 cctcagccgc agcggcgacc cgctccgcct ccgccttgcg gtcggcctcg acacgctccg
    26401 ccgcagcccg ctccgcctcg gccgcaaccg ccgcggcccg gtcggcctcc gcggcagcgg
    26461 ccgccctccg agcctcctcg gcccgcagca aggcctcctc ggccttccgc tgcttctcca
    26521 ggcgccgcgc ctccgcctcg tcccgcagcc gctgctcctc cgcggcctgc tgacgacgac
    26581 gttcctcctc gacccggcgc cgttcctccg cctcggcccg cgccttctcc tccgcgagga
    26641 gccgcgcctg ctcctcctcg gctcgacgac gtgcttcctc ggcccgctgc cgggcctcct
    26701 ccgcctgccg ctccgcctcg cgccgctgag cctcctccag ctcgcgccgc ttgcgctcct
    26761 cctcctcggc gcgcagccgg gcgagctcct cctggcgctc ccgctccagg cgctcctcct
    26821 cggccttccg cgcggcctct tcctcggcct tgcgccgcgc ttcttcctcg gccttgcgcc
    26881 gagcttcctc ctgcgccttc acctcggcct cggacagcgg cagcatcacg tcgagccgag
    26941 cccggaccac ggtcgtcacg gcctccgggt cctgcccggc gtccacgacc aggtaccgcc
    27001 cggcatccgc ggcggccagc gtcaggaatc ccgcccgcac ccgctcgtgg aactcggcag
    27061 gctccgactc caaccggtcc ggcgcctcgg tgaaccgctc gcgcgcggcc tccggcgaca
    27121 catccagcag caccgtcaga tgcggcacga gcccgtcggt cgcccaccgc gagatccggg
    27181 cgatctccgt gggtgagagg tcccgcccgg ccccctgata ggcgacggac gagtcgatgt
    27241 accggtccga gacgacgacc gcgccgcgtt ccagcgcggg ccgcacgacg gtgtccacat
    27301 gctcggcacg atccgcggcg tacagcaacg cctcggcacg gtgcgacagc ccggcactcg
    27361 acacgtccag cagaatcgac cgcagccgct tgcccaccgg agtcgccccc ggctcgcgcg
    27421 tcaccacgac ctcgtgcccc ttggcccgga tccactcggc gatcgcctcg acctgagtgg
    27481 acttcccggc gccgtccccg ccctccaggg cgatgaagaa acccgaagcc gcgggcgcct
    27541 gaaccggatc gtcgcccttc agcagcgcgt cccgcaggtc ctgccgcagc ggcaccccgg
    27601 accggtcgtc gaccttggcg agcaccaacg cggcgaccgg cagcagcaac gcccccacca
    27661 gcatcaacgt aaacgccgca ccgccgtgcg cgaacacgaa cttgccgctc tccagccggt
    27721 gcggcccgat gacggcggcg accagcggag cgacgagcac cgcgagcgcc acgaacaccc
    27781 gtacgacggc gtgcagatgc tcggtggtgc gggcccggcg gaagtcctcg gcctcctggt
    27841 cgagcagcgt gtgcccggtg ttggcggcga tccccgcgcc ggcaccggcg agcccgagga
    27901 cgagcacgac gctcgtgacg tccggcgtca ggccggcggc gagcagcgcg atgccggtga
    27961 acgcgatcgc gagggcgagc agccgacgcc gggacagcgc gggcagcacg gacggcgccc
    28021 ggcggatccc gacgaccacg
//
