LOCUS       NZ_CP080647            27450 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptomyces akebiae strain MG28 chromosome, complete genome.
ACCESSION   NZ_CP080647
VERSION     NZ_CP080647.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces akebiae
  ORGANISM  Streptomyces akebiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10257202)
  AUTHORS   Ping,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2021) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019599145.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 09:26:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,127
            CDSs (total)                      :: 9,036
            Genes (coding)                    :: 8,727
            CDSs (with protein)               :: 8,727
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 142 of 309
            Pseudo Genes (incomplete)         :: 231 of 309
            Pseudo Genes (internal stop)      :: 20 of 309
            Pseudo Genes (multiple problems)  :: 77 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 531140
            Orig. end                         :: 558590
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP080647.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo Ping.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27450
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22778
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22778
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12778](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12778
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(1021..2904)
                     /locus_tag="K1J60_RS02335"
                     /old_locus_tag="K1J60_02335"
     CDS             complement(1021..2904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319991.1"
                     /locus_tag="K1J60_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02335"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_220644670.1"
                     /transl_table=11
                     /translation="MSNVADMSRLRTRLLGVLVLLTGFLTTAGSTQPASALTDELWFDA
                     QAAATLTVDGGTFKDGLGREVVLRGYNVSGETKLKENNGLPFASVADAKKSATALRALG
                     GGNSVRFLLSWAYAEPVRGQVSTSYLAAATAQMGAFLDAGIKVYPDFHQDLYSRWLFDS
                     DSWYTGDGAPKWAVDLGDYPDEYCGICPFWGQNITSNAAVTEATYDFWHNTYGLQDSFL
                     DTAQKTMTYLKANLTTAQFQGLVGFDPWNEPHPGTLDSGQTSRTWEKNVLWPFYVKFRA
                     RMDAAGWQSKPAFVEPNLFWNANIDFQKQEGGLLDAGTIGPRYVFNTHFYDQKAISGVF
                     MWGKAENGQYVNDFGTVRDRATAGGTTAIVSEFGHPLSGSVSDKAPTVYKAMYQALDSR
                     VKGVDWWSNPTASGPVLSGSQWQWDIYWGRHHELMNDNPDKVQVEGDAWNDEDLSAVRL
                     DDSGTAVLRQDARMLDRIYPSATAGRTVAFTYEDRSRDGSTTLTWNPVPSSLPNVSSLV
                     GSGQYSLLVWRSDGSTEPTELHLPASFPTASTTVVSDLGVTAAPPAYTTSTPVAAAKEP
                     GGTGSRRLLLTAADTGKLHYALVTNGATAPSATQLSAARTELSNWLTTRFS"
     gene            3221..3460
                     /locus_tag="K1J60_RS02340"
                     /old_locus_tag="K1J60_02340"
     CDS             3221..3460
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS02340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_02340"
                     /product="hypothetical protein"
                     /protein_id="WP_220644671.1"
                     /transl_table=11
                     /translation="MDSSFRGLREHKPGTRDFDPRSALPRLDRLGAPDGEKRSDSRNER
                     CASLYDAIRDMGRYEAAVEAERRRTGGDDLLPGP"
     gene            3619..4095
                     /locus_tag="K1J60_RS02345"
                     /old_locus_tag="K1J60_02345"
     CDS             3619..4095
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_02345"
                     /product="hypothetical protein"
                     /protein_id="WP_220644672.1"
                     /transl_table=11
                     /translation="MRLVHVSLRSWWWGEPLAATFGGLGGAWIGHDDDLPMDEVLGVAV
                     SMVGVIIGSVFAVLAMITRACDNTFLRKARKARLLPIVNYLWPFFTIIAMGILSIVFLL
                     LMAGISEDAPTLLLMTVSASAGFCVLWTLAGLLPALGALIVFTRLIEKTSGVND"
     gene            complement(4167..4670)
                     /locus_tag="K1J60_RS02350"
                     /old_locus_tag="K1J60_02350"
     CDS             complement(4167..4670)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712783.1"
                     /locus_tag="K1J60_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02350"
                     /product="hypothetical protein"
                     /protein_id="WP_220644673.1"
                     /transl_table=11
                     /translation="MITSAVRRVVVTALGTTLALLPTSAQAEQKDQDNDIEKVELVGVN
                     RVATWPSLDGVVGGTWTTPLDLYTKHKVKKTGKTELRHAGDGESECDVVQSRAQAVTAQ
                     CTRVLRLKKGTLTLSDMVDYRPLQPVTAKTAIVGGTGHYRSAYGDGYITLDGHRTHIVL
                     NVDE"
     misc_feature    4661..4677
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.66"
                     /tool="antismash"
     gene            complement(4743..5216)
                     /locus_tag="K1J60_RS02355"
                     /old_locus_tag="K1J60_02355"
     CDS             complement(4743..5216)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K1J60_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="K1J60_02355"
                     /product="hypothetical protein"
                     /protein_id="WP_220644674.1"
                     /transl_table=11
                     /translation="MPSATARGAVTLGTLAAALTMSLAAPAAADVGDEDVVRVKLVGHA
                     AYDTAPEHTAPGDSWTTYLHLHDPKGKYVGDGGSRCTVVEADHHRFTAQCTRVLRLKGG
                     EITLHDMISRTGHKPVTAKTSIAGGTGIYNDAEGEGYITLERKRIVFDLYVDD"
     gene            5542..6651
                     /locus_tag="K1J60_RS02360"
                     /old_locus_tag="K1J60_02360"
     CDS             5542..6651
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483988.1"
                     /locus_tag="K1J60_RS02360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02360"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_220644675.1"
                     /transl_table=11
                     /translation="MREILPALGEWYAAGSPFGLATVVAVSRSAPRGPGAAMAVGPGDE
                     VVGSVSGGCVEGAVFELAQEVVASGEARSATFGYSDDDAFAVGLSCGGEITLLVRRVTA
                     TEDPSFGQVVETVGAGLPVTVATVVDGPGRRGATLAVWPDRTRGSLGTEGLDAAVAADA
                     RGELAQGVTGARHYGPHGERREDSVTVFLHSFAPPPRMLVFGAIDYAAAVARIGDFLGY
                     RVTVCDARPVFATPKRFPPTVEVVVDWPHRYLRGTATDERTVVCVLTHDPKFDVPLLEE
                     ALRRPAAYVGAMGSRRTHEDRTRRLREAGLGPGELSRLRSPVGLDLGARTPEEVAVSVA
                     AEIVALRWGGSGVPLTATTGLIHPPTPPR"
     gene            complement(6676..7179)
                     /locus_tag="K1J60_RS02365"
                     /old_locus_tag="K1J60_02365"
     CDS             complement(6676..7179)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483990.1"
                     /locus_tag="K1J60_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02365"
                     /product="metallophosphoesterase"
                     /protein_id="WP_220644676.1"
                     /sec_met_domain="Metallophos_2 (E-value: 7.5e-27, bitscore:
                     93.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLLLSDTHLPKRAKALPAPLLAELPHADVVVHAGDWVDEATLD
                     LLQARSRRLIAVYGNNDGPGLRARLPEVARAEPGGLRLAVVHETGPAQGRESRCAARFP
                     DTDVLVFGHSHIPWDTTTSTGLRLLNPGSPTDRRRRPHCTYMTATVADGVLTEVHLHRL
                     PPRT"
     gene            complement(7192..9738)
                     /locus_tag="K1J60_RS02370"
                     /old_locus_tag="K1J60_02370"
     CDS             complement(7192..9738)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057834.1"
                     /locus_tag="K1J60_RS02370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02370"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_259407521.1"
                     /transl_table=11
                     /translation="MVSEGAAEPGTRTLRAELALKTLGGDLDPYERLHAILEQVLVFTS
                     ATVAAVYLPDGEGQALSLTASAGVPRNLYGLSDSYPAAGTAPVAETCRSGRPSWLVSTD
                     LHEDADAHPVAADHPGADAHPGADAHPVAADHPVGDVQEGAGPPEDADIRRVRAESFSL
                     GVLPLRERGCLVAVGDGTDAFDAEDRHCLDLLAEAAAGAAPAPPAGFGASFDLAMDSGR
                     VEVDDALLELFGIGQDDFDGRVETLIALTVPEDLPALMSVVEADHMSIGDRELEFRILQ
                     PSGEQRWLRLRGRILPGGENRPARLVGTVADASTLRTGRGDVARIQRLAAALATAGTVR
                     DVSQAVVTALRKPLRADRIALAELEGDRLVVTVLDPPQPEVWPEVWRSEWRSEWPDAPV
                     RTMPTLATALREGRAGIWPAGAHLEPALADVGPGGLAVLPLPAGGRMAGACLIGWDSPH
                     DFGPEERALLTAASGLAGQALMRAHAFDAEHELVGMLQRTLLPRRLPQLPGAVAVARYL
                     PTTAGLEVGGDWYDVIPLPDNHVALVIGDVQGHNAGAATLMGQMRTALRAYAVEGHPPD
                     VVVSHANRLLMDMETDLFATCCYVDIDMEEGSAWYVRAGHIPPVLRHPNGSTEISESEG
                     GPPLGVVMQADFPMSPLRLTPGTVLALTTDGLVESADIDVEDGLDQLAAELSAADPAHL
                     GVVADTLLGGANRDDDVALLLIRYDGMALRPQRENWSVWRVPQAVGQARRYTRRVLRRW
                     GADSVSDSVLLVVSELVTNALVHTDGRVRLDLTLLADRLRVSVADSSPRTPVKPTVIGW
                     EATGGRGILLVEAMSSAWGTVPVSGGKQVWAEIPIE"
     gene            10001..12778
                     /gene="lanKC"
                     /locus_tag="K1J60_RS02375"
                     /old_locus_tag="K1J60_02375"
     CDS             10001..12778
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134770.1"
                     /locus_tag="K1J60_RS02375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02375"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_220644677.1"
                     /sec_met_domain="micKC (E-value: 2.2e-200, bitscore: 666.7,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 9.1e-11, bitscore: 40.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-06, bitscore:
                     25.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYEAYALADRHFYETPDLLAGDGADAASPGYETAGRAVPGGW
                     RSARIGDWLTLTPVDDGGRPRPGPTQGWKVHASATRANADRVAAIVWDYCVPRRIPFKF
                     VPGPHLLHLRNAKYAARDTSGKFVTVYPADEEQLHLVLRELGALLEGFDGPYILTDLRW
                     NDGPLYVRYGAFARSFVVDERGTLVPAVRDGAGTLVPDQRRPTFHVPDWVTLPAFLEPQ
                     LAARNTTTVGELPYRIEKALHFSNGGGVYVGTDTRDGRRVVLKEGRPHAGLAADGADAV
                     TRLEREKAALERLAGLGVVPEVRDWFTLGDHRFLVMDFVEGRPLNSYVAERHPLLAPDP
                     GPDAVAAYTAWALHVHRAVEEAVEAVHSRGIVFNDLHVFNIMVAPDERSVSLLDFEAAA
                     PAEENGRQVVAHPGFLAPWDRTGRDVDRYALACLRLALFLPVTSLLVVEREKAAHLAAV
                     IAEQFPQVPPAFLDEAVAEISRSGGGAERATDDGAQERAPARVARTRAPAAGAGVVEAG
                     WSLAEPGDWPYSRDSMVKAILASATPERDDRLFPGDVAQFSDGGGLGLAHGAAGVLYAL
                     AEVGAERYEEGERWLLDHTAPVPIGTPLGLYDGLAGVAHTLDRLGHRQRALDLVEQLLG
                     EKWHKLSSDLRGGLAGLGLVFDELARTTGEAALRDHAAQAAELLVSRLAEPRPAPPRRR
                     AGLLRGASGPALFLLRRYEATGDRALLDAAGEALRQDLECLVEQRNGGLAVDEGWRTMP
                     YLGDGSVGVAMVLDDHLAATGTTATGTDGGSDTATATGTATATGTGTGTGTGQLAPGTD
                     EFARVRAGVLTAATYRFYAQPGLFEGRAGMILHLARTGAPRERLTEQIAALGWHSMPYQ
                     GQLAFPGNHLMRLSMDLGTGTAGCLLALGAAHAAADDDTTAHLPLLPPPRRRPH"
     gene            12868..12984
                     /locus_tag="K1J60_RS02380"
                     /old_locus_tag="K1J60_02380"
     CDS             12868..12984
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483995.1"
                     /locus_tag="K1J60_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02380"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_005483995.1"
                     /transl_table=11
                     /translation="MALLDLQTMEADETTGTGGPSSLSVLSCVSAASITLCL"
     CDS_motif       12868..12927
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQTMEADETTGTGGP"
                     /locus_tag="K1J60_RS02380_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12928..12984
                     /prepeptide="core"
                     /locus_tag="K1J60_RS02380_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="14.10"
                     /molecular_weight="1627.9"
                     /monoisotopic_mass="1626.9"
                     /core_sequence="SSLSVLSCVSAASITLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQTMEADETTGTGGP"
                     /leader_location="[12867:12927](+)"
                     /alternative_weights="1646.0"
                     /alternative_weights="1664.0"
                     /alternative_weights="1682.0"
                     /alternative_weights="1700.0"
                     /alternative_weights="1718.0"
     misc_feature    12875..12895
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            13327..15126
                     /locus_tag="K1J60_RS02385"
                     /old_locus_tag="K1J60_02385"
     CDS             13327..15126
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998778.1"
                     /locus_tag="K1J60_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02385"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_220644678.1"
                     /transl_table=11
                     /translation="MTTLTEGAAHCPAAVSDPLLRATVRHSGPRCTALALVSMASTGAN
                     LSLPVALGRALDLLLARDPDGSRWVLWCAALVLAVAVLDAVETVLGGTTNARATAWLRH
                     RLVRHALAVGPRALTRFGPGDLVARLVGNAAQAGTAPATAAALLAALAGPLGAVAALAL
                     IDPRLAAVFLIGAPLLALVLRALARDSSDCVTRYQRAQGRIAGGLAEAVAGHRTIVAAG
                     TADRTVARVLRPLAELSDQGHRMWHVQGRAAARAATVAPLLQLAVVATAGVLLARQHLS
                     VGELLAASRYAVLAAGVGVLVGQLSGLVRARTAAERLDEVRSEPPTTYGERALPPAGTG
                     RLELRSVTVRRGGRTVLDRVDLVVPAGATVAVVGRSGAGKSLLAAVAGRLTDPDDGEVR
                     LDGVPLPELDRRELRRAIVHAFERPALLGGSVEDTIAFGVVRPSPARIREAARAAHADG
                     FVRRLPDGYATPCADAPLSGGEAQRLGLARAFARDSRLLVLDDALSSLDTLTEHDITDA
                     LLRPTTGGSRLLIAHRVTTAARADTVVWLEKGRVRAVGPHTELWRTADYRELFGSWAPV
                     GTGRADAARDGTASRGVPGGEGR"
     gene            15123..17105
                     /locus_tag="K1J60_RS46820"
                     /old_locus_tag="K1J60_02390"
     CDS             15123..17105
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128987.1"
                     /locus_tag="K1J60_RS46820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02390"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_317619690.1"
                     /transl_table=11
                     /translation="MKGGRGGRRRAGGGLRPPGLLRRGLRFLRGRARVVARLVLWSVVE
                     TGQTFLMGYALARALDDGFLVGRAGVGLGWLGAGAGAVVLGALGTWRVYGCVAGLVEPL
                     RDRLVRGVVERGVREADGGALSGLTQQVEIARDTFAGLVMVSRSFLFTSAGALVGLFSL
                     APPLLLVVGPPLLVGVALFLVTLRPLARRQEGFLVADEALADRLGAVCPGLRDITAAGA
                     EDTVAADTGRCVDAELRAARSLARWGVARVASLAIGGQLPVVLLLVTAPWLLDHGVTAG
                     ALVGALAYVTQSLLPALQNLVHGLGTSGSRLAVVLRRLAPVPAPPPPKDAPRPSTPTPS
                     PADPGVPGEADVRDALPRAAASHDALRLASVTFAYGSRGTPVLDGLDLRIPHGTHLAVV
                     GPSGVGKSTLTGVVAGLLRPRHGTVHLCGRPVPGVTSRAHRVLIPQEAYVFGGSLEENL
                     GELRPKPVPEDELWAAAEAVGLTEVMVRLGGPAAEVDPRALSAGERQLVALGRAYLSYA
                     SVVILDEATCHLDAEAEERAERAFARRPGTTLVVVAHRVSSARRADRVLLMDGRSAAYG
                     DHDDLMARSPLYRDLVGAWSPVPVPVRSPGASEPSLPLRDPDGVDPVARPRLTGDRGHV
                     VAHGSVGEVQAAGDLRDGGSLGSQG"
     gene            complement(<17028..17642)
                     /locus_tag="K1J60_RS02395"
                     /old_locus_tag="K1J60_02395"
                     /pseudo=""
     CDS             complement(<17028..17642)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="K1J60_RS02395"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02395"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAGSSRPGMVGDANNGHALSGGHRWPAGGGANVIRVLLVHDECLV
                     RSVLAEWLCREPDLAVFDASWRVAPGRVRTLRPEVCAADLDCADAVGIPPLADLRGTGG
                     PAPGLLVLAHAGRPGLLKRAAEAGALGYVDKEGSPQRLVSAIREVARGRRFIDDSLGFG
                     FLKAAEMPLTRRELSVLSLAAEGASVAEIAGSLHLSHGTVRN"
     misc_feature    complement(17103..17105)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     cand_cluster    17235..27450
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    17235..27450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[22234:22450](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22235..22450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     misc_feature    complement(17800..17815)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            17829..19973
                     /locus_tag="K1J60_RS02400"
                     /old_locus_tag="K1J60_02400"
     CDS             17829..19973
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115095.1"
                     /locus_tag="K1J60_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02400"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_220644679.1"
                     /transl_table=11
                     /translation="MSDVHVSGARTTVETGRVGHPLLSLALAAMMDDVQAHSGAVYLLT
                     PDEPVLEMAVMAGLPRSFAAPWERVGLNSPIPVSEAVRGRRLVWVNGEEQMARRYPRIA
                     VVLPYPFALAALPVATRDTIYGAVFLTWPGSHPPELSERERDQLTSACDRLAMRLRRAE
                     DEGRPVLPEPDLSAPSTTTVAGTLGTVEAARMVARLPYGMCALDLHGRITFANAATAEL
                     LGIPVSGLLGTQLWVSVPWLNDPAYEDRYRAALMSQHVTSFVALRPPSDWLSFRLYPGS
                     NGLSVRISRARAVAEAEHASREEDHGPGRLVTIHHVLALASALTEAVGVQDVVDLVADE
                     IAPAIGSQALVMLGSRAGRLHVLGHRGYADPHLVERFDGMPLTAAMPGAHALTTGVPAF
                     FESRQQLEHLYPLRQETPDGLGAWAYIPLIASGRPVGTWVLGYAEPHPFPAEERAVLTS
                     LSGLIAQALERALLYDAKHQVAHGLQKALLPHSLPSIPGIESASRYLPATRGMDIGGDF
                     FDLVLSHGRASAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQTPEEVMSSTNRLLIDL
                     GSELFASCLYLRLDPEHGTAVMARAGHPPPLLRRPDGKVRVLDLAGGPLLGIDAAATYP
                     TTEVALTEGSVLVLYTDGLIESPGVDIEDALADLGERLSSAGERPLDALADSLVRETEA
                     AEERADDVALLLLRATGSAG"
     gene            complement(20138..21526)
                     /locus_tag="K1J60_RS02405"
                     /old_locus_tag="K1J60_02405"
     CDS             complement(20138..21526)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994899.1"
                     /locus_tag="K1J60_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02405"
                     /product="S1 family peptidase"
                     /protein_id="WP_259407523.1"
                     /transl_table=11
                     /translation="MSHKRATKRKAFIAAGGVAALGAAALILPNAMASQTDAKGAAPKT
                     LAASDASDLASQLQDLLGDAFAGAYYDSGEQRLIINVIDGLQIEGDDNNVIIQAQEAGA
                     EVREVENSWSELLKGAATLKEEATVPGTAWAIDPRTNKLQVTADSTVTGENWDTIESTV
                     KSLGADMATIKKSAGTFKPFLEGGDAIFGGGARCSAGFNVVNAEGAPAFLTAGHCGVAE
                     AEWSEEEGGAPIGTVDAATATFPGAGDFALVDYNDPATQAASTVDLGNGQTVDITAAGE
                     AAVGLQVFRMGSTTGLADGQVTGLEATVNYPEGTVTGLIQTNVCAEPGDSGGSLFTEDG
                     QAIGLTSGGSGDCTVGGETFFQPVTTALAATGATLGDAGAGAGEEADGGAAAGAGEEGG
                     AAAAGAGEEEGAAAAGAGDEGAVAGAGDEGAGDAGAAAGAGEAGQEHEQGVEEQGVEEQ
                     GVQQ"
     misc_feature    21687..21697
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    21912..21926
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    21912..21927
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    complement(21914..21925)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    22137..22153
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.12"
                     /tool="antismash"
     misc_feature    complement(22204..22217)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.67"
                     /tool="antismash"
     misc_feature    complement(22217..22233)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            22235..22450
                     /locus_tag="K1J60_RS02410"
                     /old_locus_tag="K1J60_02410"
     CDS             22235..22450
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="K1J60_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02410"
                     /product="hypothetical protein"
                     /protein_id="WP_033528587.1"
                     /sec_met_domain="strepbact (E-value: 6.6e-36, bitscore:
                     121.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETAEISDAALDAVSGGLSVNAVGTVTGLVDGIAPVSGL
                     VNTAVGTVEGVTGLNTAPVTSLVAGL"
     gene            22597..23403
                     /locus_tag="K1J60_RS02415"
                     /old_locus_tag="K1J60_02415"
     CDS             22597..23403
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="K1J60_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02415"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_220644680.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLVLSVTVIAMAAASVW
                     AVTGSVASTVGAPAVLTHGQGSYVLQSPVAGQVTAVLAKQGERLPAKAPVLKVATTDGE
                     TVVRSVAAGRVSALAATIGQIIQTGANVAAVEKVADADDPLYATVYVPAENAASIPKDA
                     EVDLTVQSAPTQRYGVLRGHVKKVDRTAQTPQSIGAFLGDTQLGEQFTKKGRPVAVTVR
                     LDRAASTESGYRWSSQDGPPFELTSMTMATASIRMADERPIDWLLP"
     gene            23472..25637
                     /locus_tag="K1J60_RS02420"
                     /old_locus_tag="K1J60_02420"
     CDS             23472..25637
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995671.1"
                     /locus_tag="K1J60_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="K1J60_02420"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_259408218.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-38, bitscore:
                     130.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRGRQKTVRTPTVLQMEAVECGAASLAMVLGHYGRHIPLEELRI
                     ACGVSRDGSRASNLLKAARSYGLTAKGMQMDVAALAEVKAPAVLFWEFNHYVVYDGMGR
                     RFGRRGVHINDPGKGRRFVPMEEFDSSFTGVVLVMEPGADFAKGGRRPGVLGAMPARMR
                     GTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQTSLLGVLFASMGACVLLTVL
                     LTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTFFSQRSPADLVQRLQSNDAVAETLA
                     RDLAAAGVDAVVVVLYAVLLYTYDPQLTFVGIAVALLNVVAMRVVIRLRATRTAKLRAD
                     NARLTNTAYTGLQLIETMKATGGEEGYFRKWAGQHATTLEEQQRLGVPSAWLGVVAPTL
                     ATINSALILWIGGMRAVEGHISVGLLVAFQALVTRFTAPLTRLNGVAGRIQDFAADVAR
                     LKDVENFRADPLYARPDSAESTRRLNGHVELENITFGYSPLDKPLLTGFDLTVGPGQQV
                     ALVGGSGSGKSTVSRLISGLYTPWEGVIRIDGRRLEDIPRGALAASVSFVDQEVFLFEG
                     TVRDNVALWDPSIPEEAVVEALRDAALYDVVTRRPGGINSRVEQDGRNFSGGQRQRLEI
                     ARALVRRPSILVLDEVTSALDAETELTVMDNLRKRGCACVVIAHRLSTVRDSDEIVVLQ
                     HGTIVERGRHEELVARGGAYAQLVRER"
ORIGIN
        1 tggcggagat caacgccgat ccgatccgct ggatcgcgtt catgacgatc cgcaacagcg
       61 tgggcgaggg ccacgaccag ttcgtggacg acatgtactc cacaccggac ggctcgtcga
      121 tggtggtctc ccggccgagc ttcgccgacg tggtctccat cgacgtcagg accggcgcca
      181 tcaactggcg cttcgcggtg tcgggttacc gcgccgacca catggcggtc tcccccgacg
      241 gcaagcgcgt ggcggtgtcc gcgtcgaccg gcaacaccgt gcacgtcctg gacatcgtca
      301 ccggcaagca ggtcggttcg ttcaagaccg gcgacaagcc gcacgagaac atcttcacca
      361 aggacggcaa gtacatctgg aacatggcga tcggtgatgt gaacacccag accgacgcgc
      421 cctggctgga ctggacgaag ggtgaccgga agatcaccgt cgccgacgcg aacaccttcc
      481 agcaggtcaa ggtgatcgac atgcgggagc ggctcaacgc gatcgggctg agcgactact
      541 cggacgcggt ccgtcccgcc gcgttctcgc ccgacgagac gaagctgtac ttccaggtgt
      601 cgttcttcaa cggcttcttc gagtacgaca tcgccaccga caagatcacc cgcaccaaga
      661 ccctgccgaa gtcccccggg gtcagcgacg accgcaccac cttcgtcaac gactcccgcc
      721 accacggtct gaccatgaag ccggacggca ccaagctgtg catcgcgggc acgatggacg
      781 actacgcgac cgtcgtggac cgcgcgaccc tccaggaggg cccgctcgtc cccgtctcca
      841 agccgtactg gtcgaccgtc agcggtgacg gcaagtcctg tgtggtctcc gagagcggcg
      901 ccgaccaggt caccgcgatc gacttcgcca ccgggaagaa gaccgtgtcc gtcgcagtcg
      961 gcgaccaccc ccagcgggtg cgggtggcga aggtgcccgc cgactggacc ggaccctcgg
     1021 ctaactgaac ctggtggtca gccagttgga cagctccgtc cgtgccgcgc tcagctgcgt
     1081 ggcggacggg gctgtcgcgc cgttggtgac cagggcgtag tgcagcttgc ccgtgtcggc
     1141 ggcggtgagg agcaggcgac ggctgccggt gccgcccggt tccttggcgg cggcgaccgg
     1201 cgtggacgtg gtgtacgccg gcggtgcggc cgtcaccccg aggtcggaca ccaccgtggt
     1261 ggacgcggtg gggaaggacg ccgggaggtg cagctcggtc ggttcggtgc tgccgtccga
     1321 gcgccagacc aacagggagt actggccgga gccgaccaac gaggagacgt tcggcaggga
     1381 gctgggcacc gggttccagg tcagcgtcgt ggagccgtcg cgcgagcggt cctcgtaggt
     1441 gaaggcgacc gtccggcccg cggtggcgct cgggtagatc cggtccagca tccgggcgtc
     1501 ctgccggagc acggccgttc cggagtcgtc gagccgtacg gcggagagat cctcgtcgtt
     1561 ccaggcgtcg ccctcgacct gcaccttgtc ggggttgtcg ttcatcagct cgtggtggcg
     1621 gccccagtag atgtcccact gccactggga gccggagagg accgggccgg aggcggtcgg
     1681 gttcgaccac cagtcgacgc ccttcacccg ggagtcgagc gcctggtaca tggccttgta
     1741 gaccgtgggc gccttgtcgg agaccgagcc gctgagcggg tgtccgaact cgctgacgat
     1801 ggccgtcgtg ccgccggcgg tggcccggtc acggacggta ccgaagtcgt tcacgtactg
     1861 gccgttctcc gccttgcccc acatgaagac gccggagatc gccttctggt cgtagaagtg
     1921 ggtgttgaag acgtagcgcg gtccgatggt gcccgcgtcg aggagtccgc cctcctgctt
     1981 ctggaagtcg atgttggcgt tccagaagag gttcggctcg acgaacgccg gcttggactg
     2041 ccagcccgcc gcgtccatcc gggcacggaa cttgacgtag aacggccaca ggacgttctt
     2101 ctcccacgtc ctgctggtct gcccggagtc gagggtcccg gggtgcggct cgttccacgg
     2161 gtcgaagccc acgaggccct ggaactgggc ggtcgtgaga ttcgccttca gatacgtcat
     2221 cgtcttctgc gcggtgtcca ggaaggagtc ctggagcccg taggtgttgt gccagaagtc
     2281 gtacgtcgcc tccgtcacgg ccgcgttgga ggtgatgttc tggccccaga acgggcagat
     2341 gccgcagtac tcgtcggggt agtcgccgag gtcgacggcc cacttggggg cgccgtcgcc
     2401 ggtgtaccag ctgtcggagt cgaacagcca gcgggagtac aggtcctggt ggaagtcggg
     2461 gtagaccttg atcccggcgt ccaggaacgc gcccatctgg gcggtggccg ccgcgaggta
     2521 ggaggtgctc acctgcccgc gcaccggttc cgcgtacgcc caggagagca ggaagcggac
     2581 ggagttgccg ccgccgagcg ccctgagcgc ggtcgccgac ttcttcgcgt cggcgaccga
     2641 cgcgaagggc agaccgttgt tctccttgag tttcgtctca cccgagacgt tgtagccgcg
     2701 caggacgacc tcgcggccga ggccgtcctt gaaggttccg ccgtcgaccg tgagggtggc
     2761 cgcggcctgg gcgtcgaacc agagttcgtc agtgagagcg gaggcgggct gggtggagcc
     2821 cgccgtggtc aggaagccgg tgaggagtac cagaacaccg agcagacgag tgcgcaatct
     2881 tgacatgtcc gccacattcg acatgtgcac taccgtccca atgggcaggc gagccgtcaa
     2941 tagcaactga cgcacgagta agtacccatt ttcgcaagac agttcacttt tcacggccga
     3001 ttctttgccc tcgcgcgacc acgccggggc tcgccgccga ccgccggggc gaccgggccg
     3061 cacgggggac gccgccgacc gcggccctgc ggaattcagc cgatgttcac ccgaacgtca
     3121 ccacgaaggg ccctgccgac ggaaccggcc tatggttgag cgcagtttga gccgatttgt
     3181 tccgtactcc gtccggcaca cctgaaaggc ggtacgagcg gtggacagct cttttcgcgg
     3241 gctccgcgaa cacaagccag gcactcgtga cttcgacccg aggagcgccc tgccccgtct
     3301 cgaccgcctc ggggcaccgg acggggagaa gcgctcggat tcgcggaacg agcgctgcgc
     3361 gtcgttgtac gacgcgatac gggacatggg caggtacgag gcggcggtgg aggcggagag
     3421 acgccggacg ggcggtgacg acctcctgcc cggcccgtga cgaagtgacg cgaaaggccg
     3481 agccgcgtgt gaggggctcg gcgtgactga ccaccatcgg gctgggcttg catgggcaca
     3541 gaaccgcgga ccgacactgg ctcgtccccc gaggagcccc cgggacgcac cacggggaac
     3601 aagtacttca aggagttcat gaggcttgtg cacgtgagcc tgcggagctg gtggtggggg
     3661 gaaccgctgg cggcgacgtt cggcggtctc gggggcgcct ggatcgggca cgacgacgac
     3721 ctgccgatgg acgaggtgct gggcgtcgcc gtctccatgg tgggtgtcat catcgggtcc
     3781 gtgttcgccg tcctggcgat gatcacccgc gcctgcgaca acacctttct gcgcaaggcg
     3841 agaaaggccc ggctcctccc catcgtcaac tatctgtggc cgttcttcac catcatcgcc
     3901 atggggatcc tgtccatcgt gttcctgctg ctgatggcgg gaatctccga ggacgcgccc
     3961 acactgctgc tcatgacggt cagtgcgtcg gcgggcttct gcgtcctgtg gacactggcc
     4021 ggtctgctgc ccgctctggg ggcgctcatc gtgttcaccc gcctcatcga gaagacctcg
     4081 ggcgtgaacg actgaggacg gcccggacgg caccggtgcg gggacgcgcg catcacgtct
     4141 cccgcaccgg tggggtcagc ctcgcgtcac tcgtcgacgt tcagcacgat gtgggtccgg
     4201 tgaccgtcca gcgtgatgta gccgtctccg taggcggagc ggtaatgccc ggtgccgccg
     4261 acgatggccg tcttggccgt gaccggctgc agcggccggt agtcgaccat gtcgctgagg
     4321 gtcagcgtgc ccttcttcag gcgcagcacg cgggtgcact gcgcggtgac cgcctgggcc
     4381 cggctctgca ccacgtcgca ctccgactcg ccgtcaccgg cgtggcgcag ctccgtcttc
     4441 ccggtcttct tgaccttgtg cttggtgtac aggtccagcg gggtggtcca ggtaccgccc
     4501 accacaccgt ccagggacgg ccaggtggcg acccggttga cgccgacgag ctcgaccttc
     4561 tcgatgtcgt tgtcctggtc cttctgctcg gcctgcgccg acgtcggaag aagggcgagg
     4621 gtggtgccta gggcggtcac gaccaccctg cggacagccg atgtgatcac agaacctcca
     4681 gttcggacgg ggtgcactcg gacggcggaa cggccgacgt gccgtcggcg cgtgtgtgcc
     4741 ggtcagtcat cgacgtagag gtcgaagacg atgcgcttgc gctccaaggt gatgtagccc
     4801 tcgccctcgg cgtcgttgta gatgcccgtg ccgcccgcga tggaggtctt ggcggtgacg
     4861 ggcttgtgac ccgtgcggct gatcatgtcg tggagggtga tctccccgcc cttgaggcgc
     4921 agcacccgcg tgcactgggc ggtgaaccgg tggtggtccg cttcgacgac ggtgcagcgc
     4981 gagccgccgt cgccgacgta cttgcccttc gggtcgtgca ggtgcaggta cgtggtccag
     5041 ctgtcgcccg gcgcggtgtg ttccggggcg gtgtcgtacg cggcatgacc gacgagcttg
     5101 acccgcacga cgtcctcgtc cccgacgtcc gccgcggccg gcgcggcgag cgacatggtg
     5161 agagctgcgg ccagggtgcc gagggtcacg gcgccgcggg cagtggctga gggcatgcat
     5221 cctcccaggt gggtgactgt gggtgttcgg aatcaggaac atggtcattt catgtaccgg
     5281 gggcccgcat ggcaacgcgc cttgcgcggc gggcggcgca ggccacccga acaggggcgc
     5341 ggacggtcgt cctcctgggc gtccgggcac ccgatcggcc cccttcacgc gtgtgcacgt
     5401 cggcaggggg cgacccgtcg gtgtgccgta ccccggccct cgtacttgga tggaggggga
     5461 gccccccggg gccgcggtcc ccggcacatc cacggtccgg cccgctcggg cgtccggcgg
     5521 tggtggcgag aggagcggac gatgcgtgag atcctcccgg cgctcggcga gtggtacgcg
     5581 gcgggctccc ccttcggcct cgccaccgtc gtcgcggtca gccggagcgc gccgcgcggg
     5641 ccgggggcgg ccatggcggt cgggcccggg gacgaggtcg tgggcagcgt ctccggcggc
     5701 tgtgtggagg gcgcggtgtt cgagctggcc caggaggtcg tggcgtccgg cgaggcacgg
     5761 tcggcgacct tcggctacag cgacgacgac gcgttcgcgg tggggctgag ctgcggcggg
     5821 gagatcacgc tcctggtgcg ccgggtgacg gcgaccgagg atccgtcgtt cgggcaggtc
     5881 gtcgagacgg tgggcgccgg gcttccggtg acggtggcga ccgtggtcga cggccccgga
     5941 cggcgcggtg ccacgctggc ggtgtggccg gaccggaccc gcggctccct cggtacggag
     6001 ggcctggacg ccgcggtcgc ggccgacgcg cgcggggagc tggcccaggg ggtcaccgga
     6061 gcgcggcact acggcccgca cggcgagcgg cgcgaggact cggtcaccgt cttcctgcac
     6121 tccttcgcgc cgccgccccg catgctggtc ttcggcgcga tcgactacgc ggcggcggtg
     6181 gcccgtatcg gcgacttcct cgggtaccgg gtcaccgtgt gtgacgcccg cccggtcttc
     6241 gccaccccga aacgttttcc ccccaccgtc gaggtggtcg tcgactggcc gcaccgctat
     6301 ctgcgcggca ccgccaccga cgagcgcacc gtcgtctgcg tcctcaccca cgaccccaag
     6361 ttcgacgtgc cgctcctgga ggaggcgttg cgccggccgg cggcgtacgt cggggctatg
     6421 gggagccgcc ggacgcacga ggaccgcacc cggcggctgc gggaggccgg gctcggcccg
     6481 ggcgaactgt cccggctgcg ctctcccgtc ggcctggacc tcggtgcccg tacaccggag
     6541 gaggtggccg tgtccgtcgc ggcggagatc gtcgcgctga ggtggggcgg cagcggggtg
     6601 ccgctgaccg cgacgaccgg gctgatccat ccgccgaccc cgccccggtg agcggggcgg
     6661 cggcgcgtcc cccgctcagg tcctgggcgg cagtcggtgc aggtggacct ccgtcagcac
     6721 gccgtccgcg accgtcgccg tcatgtaggt gcagtggggc cggcggcggc ggtcggtcgg
     6781 ggagccgggg ttgagcaggc gcaggccggt ggacgtggtc gtgtcccacg ggatgtggct
     6841 gtggccgaag accaggacgt cggtgtcggg gaagcgggcg gcgcagcggg attcgcggcc
     6901 ctgggcgggg ccggtctcgt ggacgacggc caggcgcagc ccgcccggtt cggcacgggc
     6961 cacctcgggc agacgggcgc gcagcccggg gccgtcgttg ttgccgtaca cggcgatcag
     7021 ccgccgtgag cgggcctgga ggaggtcgag ggtggcctcg tccacccagt cgccggcgtg
     7081 cacgaccacg tcggcgtgcg gcagttccgc gaggagcggc gcgggcagtg ctttggcgcg
     7141 cttgggcagg tgggtgtcgg agaggagcaa caggcgcacc cggccagcgt gtcactcgat
     7201 ggggatctcc gcccacacct gcttcccgcc gctgaccggg accgtgcccc acgcggagga
     7261 catggcctcg acgagcagga tgccgcggcc gccggtggcc tcccagccga tgacggtggg
     7321 tttcaccggg gtgcgtgggg aggagtcggc gacggagaca cgcaggcggt cggcgagcag
     7381 ggtgaggtcg aggcggaccc ggccgtcggt gtgcacgagg gcgttggtga ccagctcgga
     7441 caccacgagg agcacgctgt cggacacgga gtcggcgccc cagcggcgca ggacgcgccg
     7501 ggtgtagcgg cgggcctgcc cgaccgcctg ggggacgcgc cacacgctcc agttctcgcg
     7561 ctgggggcgc agcgccatgc cgtcgtagcg gatgaggagc agggccacgt cgtcgtcacg
     7621 gttggcgccg ccgagcaggg tgtcggcgac cacgccgagg tgcgcggggt cggcggcgga
     7681 cagttcggcg gcgagttggt cgagcccgtc ctcgacgtcg atgtccgcgg actccaccag
     7741 gccgtcggtg gtgagggcca gcacggtgcc gggggtcagt cgcagggggc tcatcgggaa
     7801 gtcggcctgc atcacgacgc cgagcggcgg gccgccctcg gactcgctga tctcggtgct
     7861 gccgttcggg tgacgcagca cgggagggat gtggccggcg cggacgtacc aggcggagcc
     7921 ctcctccatg tcgatgtcga catagcagca ggtggcgaag aggtcggtct ccatgtccat
     7981 gaggagccgg ttggcgtgcg agacgacgac gtccgggggg tgcccctcca cggcgtacgc
     8041 acgcagcgcg gtgcgcatct gacccatcag ggtggcggct ccggcgttgt ggccctggac
     8101 gtcgccgatg acgagggcca cgtggttgtc gggcagcggg atcacgtcgt accagtcgcc
     8161 gccgacctcc agaccggcgg tggtgggcag atagcgggcc acggcgaccg cgccgggcag
     8221 ctggggcagc cgccgcggga gcagggtgcg ctggagcatg cccacgagtt cgtgctcggc
     8281 gtcgaaggcg tgggcccgca tcagcgcctg cccggccagg cccgaggcgg cggtgagcag
     8341 ggcacgttcc tcgggaccga agtcgtgggg gctgtcccag ccgatcaggc acgcccccgc
     8401 catgcggccg ccggcgggca gcgggaggac ggcgaggccg ccggggccga cgtcggccag
     8461 ggccggctcc agatgggctc cggcgggcca gatcccggcg cgtccctcgc gcagggcggt
     8521 ggcgagggtc ggcatggtgc gcaccggcgc gtccggccac tcggagcgcc attcggagcg
     8581 ccacacctcg ggccagacct ccggctgcgg cggatcgagg acggtgacga ccaggcggtc
     8641 gccctccagc tcggcgaggg cgatccggtc ggcccgcagc ggtttgcgca gggcggtcac
     8701 cacggcctgg ctgacgtccc ggacggtgcc ggcggtggcc agggcggcgg cgaggcgctg
     8761 gatgcgggcc acgtcgccgc gaccggtgcg cagggtggag gcgtcggcga cggtgccgac
     8821 gagacgggcg ggccggttct ccccgccggg caggatccgg ccgcgcagcc ggagccacct
     8881 ctgctcgccg gacggctgca ggatgcggaa ctccagctcc cggtcgccga tggacatgtg
     8941 gtccgcctcc acgacggaca tcagcgccgg caggtcctcg ggcacggtca gcgcgatcag
     9001 cgtctcgacc cggccgtcga agtcgtcctg gccgatgccg aacagctcca gcagcgcgtc
     9061 gtcgacctcg acccgcccgg agtccatggc gaggtcgaac gaggctccga acccggcggg
     9121 cggggcgggg gcggcaccgg cggccgcctc ggcgagcagg tcgaggcagt gccggtcctc
     9181 ggcgtcgaag gcgtccgtac cgtcgccgac ggccacgaga cagccgcgct cgcgcagcgg
     9241 cagcacgccc agggagaagc tttcggcccg gacacggcgg atgtcggcgt cctcgggggg
     9301 accggcgccc tcctggacgt cgccgacagg gtggtcggcg gcgaccgggt gggcgtctgc
     9361 gccagggtgg gcgtctgcgc cagggtggtc ggcggcgacc gggtgggcgt ctgcgtcctc
     9421 gtgcaggtcg gtggagacga gccagctcgg tcggcccgaa cggcacgtct cggccacggg
     9481 agcggtgccc gcggccgggt agctgtcgga gagcccgtac aggttcctcg gcacgccggc
     9541 ggacgcggtg agggacagcg cctgcccctc accgtccggg aggtacacgg ccgcgacggt
     9601 cgcactggtg aacacgagca cctgttcgag gatggcgtgc agccgctcgt acggatcgag
     9661 atcgccgccg agcgtcttga gcgcgagttc ggcgcgcagc gtcctcgttc ctggttccgc
     9721 agcgccctca ctgaccacgt ccgcaattac agcgcttccg gcacgctcgc gcagcccctg
     9781 ggaccgttcc gcgaggccgg ggccctgccg cggggagccg caggactcga aaaagaccga
     9841 acagatcttt acgcgtgcgt tccgcacggt ggtcgcgtga cagccgtgac gggtcagtgg
     9901 tgacagccgt gactgtcggg ccccggggcg ggctggaagg ctcgtcctca cccggcccag
     9961 ggggcgacgg cggtgacggc acacgacccg ggggacgcgc atggacaagc ggtacgaggc
    10021 ttacgcgctg gccgaccgac acttctacga gacaccggac ctattggccg gtgacggcgc
    10081 cgacgcggcg tcgccgggct acgagacggc cgggcgcgcg gtccccgggg gctggcggtc
    10141 cgcccggatc ggggactggc tgacgctgac cccggtcgac gacggcgggc ggccccgtcc
    10201 cggacccacc cagggatgga aagtgcacgc ctcggccacc cgggcgaacg cggaccgcgt
    10261 cgcggcgatc gtgtgggact actgcgtgcc ccggcggatc ccgttcaagt tcgtgccggg
    10321 cccgcacctg ctccatctgc gcaacgcgaa gtacgcggca cgtgacacca gcggcaagtt
    10381 cgtgacggtc tacccggccg acgaggagca gctgcacctc gtcctgcgcg agctgggagc
    10441 gctcctggag ggcttcgacg ggccgtacat cctcaccgac ctgcgctgga acgacgggcc
    10501 gctgtacgtc cgctacggcg ccttcgcccg ctccttcgtc gtcgacgagc gcggcacgct
    10561 cgtcccggcc gtccgcgacg gcgccggcac cctggtgccg gaccagcgca ggcccacctt
    10621 ccatgtgccc gactgggtga ccctgcccgc cttcctggag ccgcagctgg cggcacgcaa
    10681 cacgaccacg gtcggcgagc tgccgtaccg catcgagaag gcgctgcact tctccaacgg
    10741 cggcggggtg tacgtcggca ccgacacccg cgacggccgc cgggtggtgc tcaaggaggg
    10801 gcgcccgcac gcggggctgg ccgccgacgg ggccgacgcg gtcacccggc tggagcggga
    10861 gaaggccgcg ctcgagcggc tcgccggcct gggggtggtg cccgaggtgc gtgactggtt
    10921 caccctgggc gaccaccgct tcctggtcat ggacttcgtc gagggccgcc cgctcaactc
    10981 gtacgtcgcc gagcggcacc cgctgctcgc cccggacccc ggaccggacg cggtcgccgc
    11041 gtacacggcc tgggcgttgc acgtccaccg ggccgtcgag gaggcggtcg aggcggtgca
    11101 ctcgcgcggg atcgtcttca acgacctgca cgtcttcaac atcatggtcg cgccggacga
    11161 gcgctcggtg tcgctgctgg acttcgaggc ggcggcgccc gccgaggaga acggccgtca
    11221 ggtcgtcgcc caccccggct tcctcgcgcc ctgggaccgc accggccgcg acgtcgaccg
    11281 ctacgccctc gcgtgtctgc gcctcgcact gttcctgccg gtcacctcgc tgctggtggt
    11341 ggaacgggag aaggccgcac atctggcggc ggtgatcgcg gagcagttcc cgcaggtgcc
    11401 gcccgcgttc ctggacgagg cggtggccga gatctcccgc agcggcgggg gcgcggagcg
    11461 ggcaacggac gacggggccc aggagcgggc acccgcacga gtggcgcgga cccgggcacc
    11521 cgcggccggg gcgggtgtcg tggaggccgg ctggtccctc gccgagcccg gcgactggcc
    11581 ctacagccgt gactccatgg tcaaggcgat cctggcctcc gcgacgccgg agcgcgacga
    11641 ccggctcttc cccggcgacg tcgcccagtt ctccgacggt ggtggcctcg ggctcgcgca
    11701 cggcgcggcg ggggtcctgt acgcgctcgc ggaggtcggc gccgaacgct acgaggaggg
    11761 cgagcgctgg ctgctcgacc acaccgcccc ggtgccgatc ggcacgccgc tcggtctgta
    11821 cgacggtctc gcgggcgtcg cccacaccct ggaccggctg gggcaccggc agcgggccct
    11881 ggacctggtc gagcagctcc tcggcgagaa gtggcacaag ctgtcctccg acctgcgcgg
    11941 cgggctcgcc gggctcggac tggtcttcga cgagctggcg cggaccaccg gtgaggccgc
    12001 gctgcgcgac cacgcggcac aggcggccga gctcctcgtg tcccgtctcg ccgagccccg
    12061 cccggcacca ccccgccgcc gtgccggcct gctgcggggc gcgagcgggc ccgcgctgtt
    12121 cctgctgcgc cggtacgagg cgacgggcga ccgcgcgctg ctcgacgcgg cgggcgaggc
    12181 gctgcggcag gacctggagt gtctcgtcga gcagaggaac ggcgggctgg ccgtcgacga
    12241 ggggtggcgc acgatgccgt acctcggcga cgggagcgtg ggcgtcgcga tggtgctcga
    12301 cgaccacttg gcggcgaccg gaaccaccgc caccggcacg gacggcggaa gcgacaccgc
    12361 caccgccacc ggcaccgcca ccgccaccgg caccggcacc ggcaccggca ccggccaact
    12421 cgccccgggc acggacgagt tcgcccgggt ccgcgcaggc gtcctgaccg ccgcgaccta
    12481 ccgcttctac gcgcagccgg ggctgttcga gggccgcgcc gggatgatcc tgcacctcgc
    12541 ccggacgggt gccccgcgcg agcggctgac ggaacagatc gccgccctcg gctggcactc
    12601 catgccctac cagggacaac tggccttccc cggcaaccac ttgatgcggc tctccatgga
    12661 cctcggtacc ggaacggccg ggtgcctgct ggcactcggc gcggcccacg ccgccgccga
    12721 cgacgacacc acggcgcacc ttccgctcct gccgccgccg cgacggcggc cccattgacg
    12781 cggctgcgcc gcccggcgcc agtcgtgacg caacactccc gtccccacca gggcccttga
    12841 gcgggccacc gatcgaaagg aagcgatatg gcacttctcg acctgcagac gatggaagcc
    12901 gacgagacca ccggcaccgg cggccccagc tccctgagcg tgctgtcctg tgtgagcgcg
    12961 gccagcatca cgctctgcct ctgacccgag cggggcgtcc cggccacccg ggacgcccgt
    13021 cggacccgca cggcggctga gtcgcgccga cggctccgga cggttcctct cccctgtccg
    13081 gggaggggcc gtccggggct catccatctg gccacccggc cgccccgctc gacggccgtt
    13141 cgtccacctt caccgggccc catcgagccc agcgggcccc tccggtcatt cgtccggccg
    13201 ttcatccggc cgttcatccg gccgttcatc cggccgttca tccggccgtt catccggccg
    13261 ttcatccggc cgttcgtccg gtccttcatc cggccgttca tccggtcgtc ccacgtcagg
    13321 acgggtatga cgaccctcac cgaaggcgct gcccactgcc cggcggcagt ctccgacccc
    13381 ctgctgcgcg ccaccgtccg ccactccggc ccccgctgca cggccctggc gctcgtatcc
    13441 atggcctcga cgggggcgaa cctgtcgctg ccggtcgcgc tgggccgggc cctcgacctg
    13501 ctgctggccc gcgacccgga cggctcgcgc tgggtgctgt ggtgcgcggc gctggtcctc
    13561 gcggtggccg tcctcgacgc ggtcgagacc gtgctcggcg gcaccacgaa cgcccgggcc
    13621 accgcttggc tgcgccaccg tctggtccgg catgccctgg ccgtggggcc acgcgccctc
    13681 acccggttcg gcccgggaga cctggtggcc cggctcgtcg ggaacgcggc ccaggcggga
    13741 acggcccccg cgaccgccgc cgcgctgctc gccgcgctcg ccgggcccct gggcgcggtg
    13801 gcggccctcg cgttgatcga cccgcggctc gcggcggtct tcctgatcgg tgccccgctg
    13861 ctcgccctcg tgctgcgcgc cctcgcgcgg gactcctccg actgcgtgac gcgctaccag
    13921 cgcgcccagg gccgtatcgc gggcggcctg gccgaggccg tcgccgggca ccgcacgatc
    13981 gtggccgccg gcacggcgga ccgcaccgtc gcccgcgtcc tgcgtcccct ggccgaactc
    14041 tcggaccagg ggcaccgcat gtggcacgtc cagggccgcg ccgccgcccg agccgccacc
    14101 gtggccccgc tcctgcaact cgccgtcgtg gccaccgccg gcgtcctgct cgcccgacag
    14161 cacctgtccg tgggcgagtt gctggccgcg tcccgctacg ccgtactggc cgcgggcgtc
    14221 ggcgtcctgg tcgggcagct ctcgggcctg gtccgcgcgc ggacggcggc agagcgcctg
    14281 gacgaggtac ggagcgagcc cccgaccacg tacggcgaac gtgccctgcc gcccgccggg
    14341 acgggccgac tggagctgcg ctccgtgacc gtccgccggg gcgggcgcac cgtgttggac
    14401 cgcgtcgatc tggtggtccc ggccggcgcc acggtcgccg tcgtgggccg gtcgggcgcg
    14461 ggcaagtcgc tgctcgcggc cgtggccggg cggttgacgg atcccgacga cggagaggta
    14521 cggctcgacg gggtgcccct gcccgagctg gaccgccggg agctgcgccg ggcgatcgtc
    14581 cacgccttcg aacgcccggc cctgctgggt gggtcggtgg aggacaccat cgccttcggc
    14641 gtcgtccgcc cctcccccgc ccgcatccgg gaggcggccc gagccgcgca cgccgacggc
    14701 ttcgtccgcc gcctccccga cggttacgcc actccctgcg ccgacgctcc tctgtccggt
    14761 ggtgaggcgc aacgcctggg cctggcccgc gcgttcgccc gcgacagtcg tctcctggtg
    14821 ctcgacgacg ccctctccag cctcgacacc ctcaccgagc acgacatcac cgacgccctc
    14881 ctgcgcccca ccaccggtgg cagccgcctg ctcatcgccc accgcgtcac cacggccgcc
    14941 cgcgcggaca cggtggtgtg gctggagaag gggagggtgc gggcggtggg gccgcataca
    15001 gagctgtggc ggacggcgga ttaccgggag ttgttcgggt cgtgggcccc ggtcggcacg
    15061 ggccgggcgg acgccgcccg cgacggcacc gcgtcgcggg gcgtgccggg cggagagggc
    15121 cgatgaaggg cggccgggga ggacgacggc gtgccggggg cggcctccgc ccgcccggcc
    15181 tcctccgtcg gggcctgcgc tttcttcgcg ggcgggcgcg ggtcgtcgca cggctggttc
    15241 tgtggtccgt ggtggagacg ggacagacct ttctgatggg gtacgccctc gcgcgggccc
    15301 tcgacgacgg gttcctcgtg gggcgggccg gggtcgggct ggggtggctc ggggccggtg
    15361 cgggggcggt ggtgctgggg gcgctgggca cgtggcgggt gtacgggtgc gtggcggggc
    15421 tcgtggagcc gttgcgggac cggctggtgc gcggggtggt cgaacggggg gtccgggagg
    15481 cggacggcgg ggcgctgtcc gggctgaccc agcaggtgga gatcgcccgg gacaccttcg
    15541 ccggactcgt catggtgtcc cgctcgttcc tgttcacctc cgccggggcg ctcgtcggac
    15601 tcttctcgct ggccccgccc ctgctgctgg tcgtcgggcc cccgctgctc gtcggcgtcg
    15661 ccctcttcct ggtgacgctc aggcccctgg cccgccgcca ggagggcttc ctcgtcgccg
    15721 acgaggccct cgccgaccgg ctcggggccg tctgtccggg cttgcgggac atcacggcgg
    15781 ccggcgcgga ggacacggtc gccgccgaca ccggccggtg cgtcgacgcc gaactgcggg
    15841 ccgctcgctc cctggcccgc tggggcgtcg cacgggtcgc ctccctcgcg atcggtggcc
    15901 aactgcccgt cgtgctgctc ctggtcaccg ccccttggct tttggaccac ggggtcacgg
    15961 cgggcgccct ggtcggcgcc ctcgcctacg tcacccagtc cctcctcccc gccctgcaga
    16021 acctggtcca cggcctgggc accagcggct cccgcctcgc ggtggtcctc cgccggctgg
    16081 ccccggtgcc cgccccaccg cccccgaagg acgccccccg gccctcgacg ccgaccccgt
    16141 cgccggcgga tcccggcgtc ccaggcgagg ccgatgtccg cgacgccctc ccccgcgcgg
    16201 cggcctcgca cgacgctctc cgcctcgcct ccgtcacctt cgcctacggt tcccgcggca
    16261 cccccgtcct cgacgggctc gacctgcgca tcccccacgg cacgcacctg gccgtcgtcg
    16321 gtcccagcgg cgtcggcaag tccactctca ccggggtcgt cgcgggtctc ctgcgccccc
    16381 ggcacggcac cgtccacttg tgtggccgcc cggtacccgg cgtcacatcc cgcgcacacc
    16441 gggtgctcat cccgcaggag gcgtacgtct tcgggggatc cctcgaagaa aacctcggcg
    16501 agctacggcc gaaacccgtg cccgaggacg agctgtgggc cgccgcggag gccgtggggc
    16561 tcaccgaggt gatggtccgg ctgggcggcc cggccgccga ggtcgacccg cgcgcgctgt
    16621 ccgccgggga acggcaactc gtcgcgttgg ggcgcgcgta tctgtcgtac gcgtcggtcg
    16681 tgatcctcga cgaggcgacc tgtcacctgg acgcggaggc ggaggaacgc gcggagcggg
    16741 ccttcgcccg tcggccgggc acgaccctcg tggtcgtcgc gcaccgcgtc agctcggccc
    16801 gccgcgcgga ccgggtgctg ctcatggacg gacggtccgc cgcgtacggg gaccacgacg
    16861 acctcatggc ccgctcaccg ctctaccggg acctggtcgg cgcctggtcc ccggttcccg
    16921 taccggtccg ctcccccggc gcctcagagc catccctccc cctgcgagat cctgatggcg
    16981 tcgatcctgt tgcgcgcccc cgtcttacgg gtgatcgcgg ccatgtagtt gcgcacggtt
    17041 ccgtgggaga ggtgcaggct gccggcgatc tccgcgacgg aggctccctc ggcagccagg
    17101 gataacacgc tcaactcccg ccgggtcagc ggcatctcgg cggccttgag gaagccgaag
    17161 ccgagggagt cgtcgatgaa acgtctccct cgggcgacct cccggatcgc ggacaccagc
    17221 cgctgcgggg agccctcctt gtccacgtag ccgagggcac ccgcctccgc cgcccgcttg
    17281 aggaggccgg gtctgccggc gtgggcgagg accagcaggc cgggggcggg gccgcccgtg
    17341 ccgcgcagat cggcgagcgg cgggatgccg accgcgtccg cgcagtccag gtccgccgcg
    17401 cagacctcgg gccgcaaggt ccgcacccgc cccggcgcga cgcgccagga cgcgtcgaac
    17461 accgccaggt cgggttcccg gcagagccac tccgccagca ccgatctgac cagacattcg
    17521 tcgtgcacga gaagtacccg gatcacgttc gcccctccgc ctgccggcca ccgatgtcct
    17581 ccgctcagcg cgtgcccatt gttggcgtcc ccgaccatgc ccgggcgcga agaaccagcc
    17641 atcggggtgc gtgggggcgc actcgcggcg cccgtgcgcg ctgccgcgca tcatcgcggg
    17701 ggcatggcgg ggtcgacagg gggtacagcg gtgtgtccgc ggcgcggctc tcgccgtgcg
    17761 cggtcggccc ccagggggga gccttgaccc tggggtctgt cgcacggtcg tgcgaggagg
    17821 tggtcggcat gtccgacgtc cacgtgtccg gagcgcggac gaccgtcgag acgggccgcg
    17881 tcggccatcc tctgctgtcg ctggcgctgg ccgcgatgat ggacgacgtc caggcccact
    17941 ccggcgcggt gtatctgctg acaccggacg agccggtgct ggagatggcg gtcatggcgg
    18001 ggctgccgag gtcgttcgcc gcgccctggg aacgggtggg actgaactcg ccgataccgg
    18061 tctccgaggc cgtgcggggg cggcgcctgg tgtgggtcaa cggcgaggag cagatggctc
    18121 gccgctatcc ccggatcgcc gtggtcctgc cctacccgtt cgccctggcc gcgctgccgg
    18181 tggcgacccg cgacaccatc tacggcgccg tcttcctgac ctggcccggc tcccacccgc
    18241 cggagctcag cgagcgcgaa cgggaccagc tgacctcggc ctgcgaccgg ctcgcgatgc
    18301 ggctgcggcg cgccgaggac gagggccgtc cggtgctgcc ggaaccggac ctgtcggcgc
    18361 cctcgacgac cacggtcgcg ggcacgctcg gcacggtgga ggccgcgcgg atggtggcgc
    18421 ggctgccgta cgggatgtgc gcgctcgatc tgcacgggcg gatcaccttc gccaacgcgg
    18481 ccacggccga actgctcggc atcccggtga gcggtctgct gggcacccag ctgtgggtgt
    18541 ccgtgccgtg gctcaacgat cccgcgtacg aggaccggta ccgggcggcc ctgatgagcc
    18601 agcacgtgac ctcgttcgtg gcgctgagac cgccgagcga ctggctgtcc ttccggctgt
    18661 acccggggag caacggcctg agcgtacgga tctcccgggc ccgcgcggtc gccgaggccg
    18721 agcacgcgtc gcgggaggag gaccacgggc cgggccgtct ggtcaccatc caccacgtgc
    18781 tggcgctggc gagcgcgctc accgaggcgg tcggggtgca ggacgtggtg gacctggtcg
    18841 ccgacgagat cgccccggcc atcggcagcc aggccctggt gatgctcggc tcccgcgcgg
    18901 ggcgcctgca tgtgctcggg caccgcggct acgccgaccc gcacctcgtg gaacgcttcg
    18961 acgggatgcc gctcaccgcg gcgatgcccg gggcgcacgc gctgaccacc ggggtacccg
    19021 cgttcttcga gtcccggcag cagctggagc acctctatcc gctgcgccag gagaccccgg
    19081 acgggctggg cgcctgggcg tacatcccgc tgatcgcctc ggggcggccg gtgggcacct
    19141 gggtgctggg gtacgcggag ccgcatccgt tcccggccga ggagcgcgcg gtgctgacca
    19201 gcctcagcgg cctcatcgcc caggcgctgg agcgggcgct gctgtacgac gccaagcacc
    19261 aggtggcaca cgggctccag aaggcgctgc tgccgcactc gctgccctcc atcccgggca
    19321 tcgagtccgc ctcgcgctat ctgcccgcca cccgtggcat ggacatcggc ggcgacttct
    19381 tcgacctggt cctctcccac gggagggcct cggccgtcat cggcgacgtg caggggcaca
    19441 acgtgacggc ggcggggctg atggggcaga tccgtacggc ggtgcgcgcg tacacgaccg
    19501 tcgggcagac gccggaggag gtgatgagca gtaccaaccg gctgctgatc gacctgggtt
    19561 cggaactgtt cgccagctgt ctgtatctgc ggctggaccc ggagcacggg acggccgtca
    19621 tggcgcgggc cgggcatccg ccgccgttgc tgcgccggcc ggacgggaag gtgcgggtgc
    19681 tcgacctcgc gggtggtccg ctgctgggga tcgacgcggc ggcgacgtac ccgacgacgg
    19741 aggtggcgct gacggagggt tcggtgctgg tcctgtacac ggacgggctg atcgagtcgc
    19801 cgggtgtcga catcgaggac gcgctggcgg atctcgggga gcgattgtcg tcggccgggg
    19861 agcggccgct ggacgcgctg gccgacagtc tggtgaggga gaccgaggcg gcggaggaac
    19921 gggcggacga cgtggcgctg ctgctgctcc gggccaccgg ttccgcgggc tgacaccgcc
    19981 acacgcacat gggtccggcc ctcccgccgg agggccggac cgtgccacct gtcggccgga
    20041 accgctgtgg tggggccgac gggtgggtcg tggggcgacg gccggggtca gtggccgctg
    20101 atccccggcc gtcgtccacg tactcggtgg cgttcgccta ctgctggacg ccctgctcct
    20161 cgacgccctg ctcctcgacg ccctgctcat gctcctggcc cgcttcaccg gcaccggcgg
    20221 cggcacccgc gtcaccggca ccctcgtcgc ccgcgccggc cacggcaccc tcgtcgccgg
    20281 cgcccgcggc tgcggcgccc tcttcctcac ccgcgcccgc ggctgcggcg cccccttcct
    20341 caccggcacc ggcggcggca ccgccgtcgg cctcctcgcc ggcgcccgcg ccggcgtcgc
    20401 cgagggtggc acccgtggcc gcgagggcgg tggtgaccgg ctggaagaag gtctcgccgc
    20461 cgacggtgca gtcgccgctg ccgccggagg tcagaccgat ggcctggccg tcctcggtga
    20521 acagcgagcc gccgctgtcg ccgggctcgg cgcagacgtt ggtctggatg agtccggtga
    20581 ccgtgccctc ggggtagttc accgtggctt cgaggccggt gacctggccg tcggcgagac
    20641 cggtggtgct gcccatgcgg aagacctgga ggccgaccgc cgcctcgccg gccgcggtga
    20701 tgtcgaccgt ctggccgttg ccgaggtcga ccgtgctggc cgcctgcgtc gccgggtcgt
    20761 tgtagtcgac cagggcgaag tcgccggcgc ccgggaacgt ggcggtcgcg gcgtcgacgg
    20821 tgccgatcgg cgcgccgccc tcctcctcgg accactcggc ctccgcgaca ccgcagtgac
    20881 cggcggtcag gaaggccggg gcgccctcgg cgttgacgac gttgaagccg gccgagcagc
    20941 gggcgccgcc accgaagatg gcgtcgccgc cctccaggaa gggcttgaag gtaccggcgg
    21001 acttcttgat ggtcgccatg tccgcgccga gcgacttgac cgtcgactcg atggtgtccc
    21061 agttctcgcc cgtgaccgtg gagtcggcgg tgacctggag cttgttcgtg cgggggtcga
    21121 tcgcccaggc ggtgccgggg acggtggcct cctccttcag cgtggccgcg cccttcagca
    21181 gttcggacca gctgttctcg acctcacgga cctccgcgcc ggcctcctgg gcctggatga
    21241 tcacgttgtt gtcgtcgccc tcgatctgaa ggccgtcgat gacgttgatg atgaggcgct
    21301 gttcgcccga gtcgtagtac gcgcctgcga acgcgtcacc gagcaagtcc tgcagctggg
    21361 aggcgagatc cgaggcgtca ctcgcggcga gcgtcttcgg ggcggcgccc ttggcgtccg
    21421 tctgcgacgc catcgcgttc ggcaggatga gggctgccgc gccgagcgcc gccacgccgc
    21481 ctgcggctat gaacgccttg cgcttggtgg ctcgtttgtg actcaactct tgacctcctg
    21541 gggacggggt ccgtaccgcc gtccggcggg tgaactgggg gcgcctggtt gccagttggt
    21601 acggatggtt ccgatggggt gttcaacgcc ccgcgaaaag attccgatct tccacttcgc
    21661 aaagcgcgct acgccccccg ttggcctgcc atttcacgac ttcccgtcgg cgcgcccggt
    21721 gggaaccccg tgacaccggc gccccacccc ccgcctcgcc acactcggct accgcccggt
    21781 ggcggtctgt cgactccgat gatcgggaaa ccggcttcag ggaatctcca caccgaatgc
    21841 ccagcggggt cacggtcgcg gggagttctg cacaggggcg aatcgcgcgt cgcgcctttg
    21901 aggcgggact gtccaattcg ttttcacgca ggcaatcaag cgcgtatgac gatgccgcga
    21961 tccatgtgaa gaagctggcc ccaagccgtg cgcaagcctg caccaatgaa ccgtcatggt
    22021 caccaagtgc gctggtgaga ggccatgttg attggatgtg cgcggcggcg atctgcttat
    22081 atccatcgca ccgcgggggc cgccgagctc tcggagacgg gagcagccag ctctccggat
    22141 cgagaagtgg gcacccacgt gcgcggccgt cgttctgtcc ccagaagggg gccgctcccc
    22201 ccttgtgaat agctatatga agggaagttc caacatgaac tccacccccc aggttgagac
    22261 cgccgagatc tcggacgccg ccctcgacgc cgtctccggt ggcctctcgg tcaacgccgt
    22321 tggcaccgtc accggcctgg tggacggcat cgccccggtc tccggcctgg tcaacacggc
    22381 cgtcggcacc gtcgagggtg tgaccggcct gaacaccgcc ccggtcacga gcctggtcgc
    22441 cggtctctga tcgagccctg acgccgctga gtcccggaac cacctgacag gttccgggac
    22501 tctcggggtg ccccggaagt cctcggctcc tgtgccgacc ggccttccgc catccagtct
    22561 tctgtcgtct cctgtcacgc aggtgaggga agtcccgtgc agttccgcca acaggccctc
    22621 gccaagctcc agtcaccgga ggaactcgac ctccccgtgc gcttcgcccg cccccagggc
    22681 tggctggtgc tgtccgtgac ggtgatcgcg atggccgccg cctccgtgtg ggccgtcacg
    22741 gggtccgtcg cctccacggt cggcgcgccc gccgtcctca cccacgggca gggcagttac
    22801 gtgctgcaga gcccggtcgc cggccaggtc accgccgtcc tcgcgaagca gggcgagcga
    22861 ctgcccgcca aggcccccgt cctgaaggtc gccaccaccg acggcgagac cgtcgtacgg
    22921 tccgtcgcgg ccggccgggt ctccgcgctc gccgccacga tcggccagat catccagacc
    22981 ggcgcgaacg tcgcggccgt cgagaaggtc gccgacgccg acgacccgct ctacgcgacg
    23041 gtgtacgtcc ccgccgagaa cgcggcctcg atcccgaagg acgccgaggt ggacctgacc
    23101 gtgcagtcgg cgcccaccca gcgctacggc gtgctgcgcg gccatgtgaa gaaggtggac
    23161 cgcaccgcgc agaccccgca gtccatcggc gcgttcctcg gtgacaccca gctgggcgag
    23221 cagttcacca agaagggccg gccggtggcc gtcaccgtac ggctggaccg cgcggcctcg
    23281 accgagtcgg gctacaggtg gtcctcgcag gacgggccgc cgttcgagct gacctccatg
    23341 accatggcca cggcttcgat ccggatggcc gacgagcgtc cgatcgattg gctgcttccg
    23401 tgaccgcgtc ccaggacacc gcccagccgc ccacgcacgg cagacgcaag gcggccccgt
    23461 cgaagcgccc ggtgccgagg ggcaggcaga agaccgtgcg cacgccgacc gtcctccaga
    23521 tggaggccgt ggagtgcggc gccgcgtccc tcgccatggt gctcggccac tacggacggc
    23581 acatcccgct ggaggaactg cgcatcgcct gcggtgtctc ccgggacggc tcgcgcgcca
    23641 gcaacctgct gaaggcggcc cgcagttacg gactgaccgc caagggcatg cagatggacg
    23701 tggccgccct cgccgaggtg aaggcaccgg ccgtcctgtt ctgggagttc aaccactacg
    23761 tcgtctacga cggcatgggg cgccgcttcg gccggcgcgg cgtccacatc aacgaccccg
    23821 gcaagggccg ccggttcgtg cccatggagg agttcgactc cagcttcacc ggtgtcgtcc
    23881 tcgtcatgga gcccggcgcc gacttcgcga agggcggtcg caggcccggt gtcctcggcg
    23941 ccatgcccgc ccggatgcgc ggcaccgccg gcacgctgcc cgccgccgtc ctcgccagcc
    24001 tcctcctggt ggcggtcggc gcggccgtcc ccgcgctgag ccgtacctac atcgacatgt
    24061 tcctgatcgg cggccagacc tccctgctgg gcgtgctgtt cgcgtcgatg ggcgcgtgcg
    24121 tgctgctgac cgtcctgctg acctggttgc agcaggccaa cctgctgcgc ggccggctga
    24181 tctcctccac cctctccagc gcccgcttcc tgcggcacct cctgcgcctg ccggtcacct
    24241 tcttctccca gcgcagcccc gccgacctcg tccagcggct gcagtccaac gacgcggtcg
    24301 ccgagaccct ggcccgggat ctcgcggcgg ccggtgtgga cgcggtcgtg gtcgtcctct
    24361 acgccgtgct cctctacacg tacgacccgc agctcacctt cgtcggcatc gcggtggcgc
    24421 tgctgaacgt ggtggcgatg cgggtggtga tccggctgcg cgcgacccgt acggcgaagc
    24481 tgcgcgcgga caacgcgcgg ctcaccaaca cggcgtacac cggactgcag ctgatcgaga
    24541 cgatgaaggc gaccggcggc gaggagggct acttccgcaa gtgggccggg cagcacgcca
    24601 ccacgctgga ggaacagcag cggctggggg tgccgagcgc ctggctgggg gtcgtcgccc
    24661 cgaccctggc cacgatcaac agcgcgctca tcctgtggat cggcggtatg cgggcggtcg
    24721 agggccatat atccgtgggt ctgctggtcg cgttccaggc tctggtcacc cggttcacgg
    24781 cgcccctcac ccgcctcaac ggggtggcgg gccgtatcca ggacttcgcg gccgacgtgg
    24841 cccggctgaa ggacgtggag aacttccggg ccgacccgtt gtacgcccgc ccggactccg
    24901 ccgagtccac gcgtcggctc aacggccatg tcgagctgga gaacatcacc ttcggctaca
    24961 gccctctcga caagcccctg ctcacgggct tcgacctcac cgtcgggccg gggcagcagg
    25021 tggcgctcgt cggcggctcc ggcagcggca agtcgacggt gtcgaggctg atctcgggcc
    25081 tctacacccc gtgggagggc gtgatccgca tcgacggccg tcgcctggag gacatcccga
    25141 ggggggcgct ggccgcctcc gtctccttcg tcgaccagga ggtgttcctc ttcgagggca
    25201 ccgtccgcga caacgtcgcc ctgtgggatc cctcgatccc ggaggaggcc gtggtggagg
    25261 cgctgcggga cgcggccctg tacgacgtgg tgacgcgtcg cccgggtggc atcaacagca
    25321 gggtcgagca ggacggacgc aacttctccg gcgggcagcg ccaacgcctg gagatcgcgc
    25381 gggcgttggt ccgcaggccc agcatcctgg tcctcgacga ggtgaccagc gcgctggacg
    25441 cggagaccga gctgaccgtc atggacaacc tgcgcaagcg cggctgcgcc tgtgtggtga
    25501 tcgcccaccg gctcagcacg gtccgcgaca gcgacgagat cgtcgtcctg cagcacggca
    25561 cgatcgtgga gcgcggccgg cacgaggagc tggtggcccg cggcggcgcg tacgcccaac
    25621 tcgtcaggga gcgatgagat gacctccgtg cacgaggacc cgagcggtca gggcggctac
    25681 gacggcgacc tcgtcctcgg cgcgctcggc gcgatgggca catccctcga ctgcgccggc
    25741 cacacccgcc tggacctcga aggcccgcag acgctgtggc tggtggcctc cggtgccctg
    25801 gacctgttcg cggtcgacgc cgtccagcag ggccactggc accatctggg ccgcctcgaa
    25861 gcgggtgcgc tgctgctcgg tccggtcgcc gggccccagc acacgctggt cgcccgcccg
    25921 ctgcgcgact gcgtggtccg gcgcatcggc ctgcgtgagc tgtaccagca agggggcacc
    25981 gagacctggt cgtacgacga gtggggcaac ccgcagctcg tacccccgca gacgagccct
    26041 ctcgaatacg ccctcgcgct gggcgtcggc cgtggcctgt ccatcctctt ccaggcgccg
    26101 atggccaccg agcaggccgc cgcgcccacc gacgacgacg tgttctggat gcgggtgccg
    26161 cccggcagtg tccagtacgg ctcgctgtac ggcgcggagg cggcggccga tctgctgatg
    26221 gacccggggg tctggcagag catggtcgac cagcagtacc ggctgctggc cacgctggac
    26281 cgctggatcg agcagctgga gcgcacccac gaggaccgta cggccgccgg gatcaaggcc
    26341 ggtgaggcag tacgcgcgca ggccgaccgc accctgctcg cctccatcgg caagtcctcg
    26401 acgaaccggc gtacgacggc cgccgacgcg gacgccacgt acgcggcctg cgggctcgtc
    26461 gcccgggcgg cggggatctc gctgtcggag ccggcgcaga gcggcaccga gagcgaccgg
    26521 ctcgaccccg tggaacgcat cgcgctcgcc tcccgggtcc gcgtccgtgc cgtacgcctc
    26581 gccggaagct ggtggcggga gaacgtcggg ccgttggtcg ggcaccgggc gctgtccggt
    26641 gcgccggtgg cgctgctgtg gcggcgcggc ggctatgtgg ccgtccagcc gtcgtccggc
    26701 cgggagacac cgatcgagaa ggcgaacgcg gccgagttcg agccgcgtgc cgtgatgttc
    26761 taccgcccgc tgcccgaacg ggtactgagt ccgctgcgcc tgatgcggtt cagcctccac
    26821 gggacgagcg gtgacatgac gggcctgctg ctcagcgggc tggtgacggt cgtgctcggc
    26881 tcgctcgtgc ccgtcgcgac gggccggatc ctgggcgagt acgtgccgaa ggcccaggag
    26941 aacctgatcg tgcaggtctg tctggcgatc atgctcgcga gtgtggtgtc ggcggcgttc
    27001 ctgctgctgc agaacctgac gatcctccgt ctggagggcc gtatcgaggc cacgctgcaa
    27061 ccggcggtct gggaccgtct gttgcggctg ccgaccaagt tcttcacctc gcgttccacg
    27121 ggcgaactgg ccagcgcggc catgggcatc agcgcgatcc gccgcaccct ggcaggcgtc
    27181 ggcccggtgg tcgcccagtc ggtgaccgtc ggagcggtga acctcgccct gctgctctgg
    27241 tacagcgtcc cgatggctct ggcggcgatc ggcatgctgg tcgtcgtggc ggcggtgttc
    27301 ctcggcctcg gtctgtggca ggtccgctgg cagcgccgtc tggtggtgct gggcaacaag
    27361 ctgaacaacc aggccttcca gaccctgcgg ggtctgccga agctccgggt ggctgccgcc
    27421 gagaactacg cctacgcggc ctgggccggc
//
