LOCUS       NZ_SISU01000002        23162 bp    DNA     linear   CON 09-SEP-2024
DEFINITION  Clavibacter michiganensis subsp. michiganensis strain 0317
            NODE_2_length_803811_cov_87.6897, whole genome shotgun sequence.
ACCESSION   NZ_SISU01000002
VERSION     NZ_SISU01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Clavibacter michiganensis subsp. michiganensis
  ORGANISM  Clavibacter michiganensis subsp. michiganensis
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Microbacteriaceae; Clavibacter.
REFERENCE   1  (bases 1 to 803811)
  AUTHORS   Peritore-Galve,F.C., Botero Rozo,D.O. and Smart,C.D.
  TITLE     Characterizing tolerance of wild tomato species to the bacterial
            canker pathogen
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 803811)
  AUTHORS   Peritore-Galve,F.C., Botero Rozo,D.O. and Smart,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-FEB-2019) Plant Pathology, Cornell University, 630 W.
            North Street, Geneva, NY 14456, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2019
            Assembly Method                   :: SPAdes v. 3.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 90.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019455805.1-RS_2024_09_09
            Annotation Date                   :: 09/09/2024 05:23:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,211
            CDSs (total)                      :: 3,157
            Genes (coding)                    :: 3,134
            CDSs (with protein)               :: 3,134
            Genes (RNA)                       :: 54
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 23
            CDSs (without protein)            :: 23
            Pseudo Genes (ambiguous residues) :: 0 of 23
            Pseudo Genes (frameshifted)       :: 4 of 23
            Pseudo Genes (incomplete)         :: 18 of 23
            Pseudo Genes (internal stop)      :: 3 of 23
            Pseudo Genes (multiple problems)  :: 2 of 23
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:12:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 768082
            Orig. end                         :: 791244
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SISU01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23162
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23162
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23162
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13162](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13162
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(766..1614)
                     /locus_tag="EOG37_RS09850"
                     /old_locus_tag="EOG37_09830"
     CDS             complement(766..1614)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="ABC-type dipeptide/oligopeptide/nickel transport
                     systems permease components"
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038645.1"
                     /locus_tag="EOG37_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09830"
                     /product="ABC transporter permease"
                     /protein_id="WP_012038645.1"
                     /transl_table=11
                     /translation="MSATLATIDAPRARPRSRARLAGGLVIPVLVVLVMLLWALVPGLF
                     ASGSPTASVAPSLQAPSAAHWFGTDSTGRDLYTRVVFGASQSVVGAVVAVLVGLVVGTL
                     LGVVAGTVGGIVDDVLMRLVDVLLAIPGLLLSLSIVILLGFGTTNAAIAVGVTSIAVFA
                     RLSRAEVVRVRISEYVEAAYGSGGTLVQVLRRHVLPNSLTPVIALAALQFGSAILQIST
                     LGFLGYGAPPPTPEWGLLVAEGRDYVATAWWLTVLPGAVVVAVVLATNRISQSIRGGQL
                     A"
     gene            complement(1611..2546)
                     /locus_tag="EOG37_RS09855"
                     /old_locus_tag="EOG37_09835"
     CDS             complement(1611..2546)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038646.1"
                     /locus_tag="EOG37_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09835"
                     /product="ABC transporter permease"
                     /protein_id="WP_086505105.1"
                     /transl_table=11
                     /translation="MSYAIRRAGQAVIVLVLAYVVAYVLLAALPGDAVLARYGSPELGL
                     APEQLAAIRESYGADRPLIVRLGESAAAFAQGQLGYSVQSGAAVSTLLATAIPSTLVLA
                     VLGLLVAVVLAVPIAFLATYGGARWIRRVFRDLPPLLVSLPVFWVGIILIQVLSFRLGL
                     VPIIGASPGEALILPVLTIAVPIAAPLAQVLIRSIDDVSAMPFVEVVRARGADTPWLLL
                     HGVGRNALLPTLTMAGLLFGELVGGAVVTEAVFGRAGVGQLTVQAVASRDSPVLLAVVV
                     LSTVAYVVINLAVDLLYPVLDARLRRGGAR"
     gene            complement(2587..4239)
                     /locus_tag="EOG37_RS09860"
                     /old_locus_tag="EOG37_09840"
     CDS             complement(2587..4239)
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016463615.1"
                     /locus_tag="EOG37_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09840"
                     /product="TIGR04028 family ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_086505104.1"
                     /transl_table=11
                     /translation="MPRPPRPVIALTALVAATGLMAGCSAGGGGDQAASGEPRAGGTLT
                     YLEPQTWTTLYPPAAGFYPNGAVVNNITDRLLWQDPETLELEPWIATALPEVNADATEY
                     TFDIRTDVTYSDGTPLTAQNVVANFDLYGKGDVDRALTVSEAINNYDRGEVVDADTVRF
                     HFTAPAPGFAQATSTINSGLVSDSTLAKADDGFGPGQAETVIGSGPFTVSGESVGTQIQ
                     LAAREDYDWAPPEAAHQGRPLVDGVDLIVAAEDSVRVGTVVAGQADVARQIEAPDEAQF
                     RTGDLQLVAAATNGVDNGINLRFRTPQLEDVRVRQAIIAGVDRQAILDTLFSDSYPLAT
                     GVLAKSALGYVDTSSYYAHDADKAAALLDEAGWVPGSDGIRQKDGRKLELVVNEALPQP
                     RSKEVVTLIQSQLAEIGVEVELFSGDQAAQTKASQDPDALEAYHSMVGRSDYDVLKSQY
                     SSTNRNVLLNRNPADGSIADPELDALLTRIASEPTTEGRQAASEAAQQRIADQAYVLPL
                     FEEPQVYGLRGDVRGFATESVGRPVFAGVWLDR"
     gene            4482..4943
                     /locus_tag="EOG37_RS09865"
                     /old_locus_tag="EOG37_09845"
     CDS             4482..4943
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012298661.1"
                     /locus_tag="EOG37_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09845"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_094117236.1"
                     /transl_table=11
                     /translation="MPDDADGIAEVHIRTWQETYAHLLPAAYLDGLDVAARAEQWRGSL
                     GDPSGAPTFVALDGDRIVGFALAGPARDEDPPRPFQLYAIDVVASAHGTGAGQALFDAA
                     VGDSPAYLWAADDNPRAAAFYRRNGFVRDGGVERQTYQGAEMVTVRMVR"
     gene            complement(4980..5726)
                     /locus_tag="EOG37_RS09870"
                     /old_locus_tag="EOG37_09850"
     CDS             complement(4980..5726)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015780271.1"
                     /locus_tag="EOG37_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09850"
                     /product="ABC transporter permease"
                     /protein_id="WP_220015535.1"
                     /transl_table=11
                     /translation="MFRAEAVKLKRSSIWIIAVLLPLLAVVTGTINLANNTQTLDSGWA
                     SFTSQVVLFYGLLFYSMGISLLAAAIWRVEHRGTNWNALLTATTRPIRLVLAKIVAILV
                     PVALMQAVLVGGTAVSGLFVLRLDGPFPVAFLLVGLIATVAALPLIAVQSLLSLLLRSF
                     AAPVALCLVGCVAGVAAVTSAALRPLAEVLPQAINTRALNLGSTAIAGSGGLTAADTLP
                     LLATSVGLGALVVLLTLAAIRVVKLR"
     gene            complement(5732..6472)
                     /locus_tag="EOG37_RS09875"
                     /old_locus_tag="EOG37_09855"
     CDS             complement(5732..6472)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038650.1"
                     /locus_tag="EOG37_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09855"
                     /product="ABC transporter permease"
                     /protein_id="WP_258380775.1"
                     /transl_table=11
                     /translation="MAIEFRKMHRLRSLPLLIGMVVAVAALSSASQFAGSTRAGFDDPG
                     AHPWAALLLGYTLMAAMTSPILTAVIASRQTDIEHQAGGWILAAGAGRTAGELCRAKLV
                     ALAVLLVPAVLIQSLLVIAAGYAAGIRVPVEVGPWALYTLLLYLVDVAFCALHVWLAAR
                     VENQLISVGVGMLGAFLAVFSLLLPSVASRAIPWGYYAVISQAGQSDAGVDYVASPLGW
                     IAGFLVVVAAAFALATVRLDRVER"
     gene            complement(6481..7380)
                     /locus_tag="EOG37_RS09880"
                     /old_locus_tag="EOG37_09860"
     CDS             complement(6481..7380)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /function="ABC-type multidrug transport system ATPase
                     component"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038651.1"
                     /locus_tag="EOG37_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09860"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012038651.1"
                     /transl_table=11
                     /translation="MSAVIATRGLTKRFRDHVAVDALDIEVPQGSVYGFLGPNGSGKST
                     TMKMLLGLTQPTSGEIHLFGQRLTPATRGGLLPSIGSMIEAPAGYGHLTGWENMRIVRD
                     MLGLAEAQVERAFATVRLTQHRDKLVRRYSLGMKQRLGIAMALARDPSLLVLDEPTNGL
                     DPAGIEEVRSLLMDLAGQGITVMVSSHLLDEIEKMAGVLGILADGRMIFQGTRAELFEH
                     SIPDLVIETSAPDRAMAEVAGAARSPEGIRLSARSKDETADIVRRLVAADVPVHEVRRL
                     PQSLEDVFMDITGRGGQL"
     gene            complement(7534..8208)
                     /locus_tag="EOG37_RS09885"
                     /old_locus_tag="EOG37_09865"
     CDS             complement(7534..8208)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /function="Response regulator containing a CheY-like
                     receiver domain and an HTH DNA-binding domain"
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038652.1"
                     /locus_tag="EOG37_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09865"
                     /product="response regulator transcription factor"
                     /protein_id="WP_012038652.1"
                     /transl_table=11
                     /translation="MTDAPAPIRVVVVDDQSLVRDGFARIVDAQPDMAAVGVCADGEQA
                     VARVVELRPDVVLMDVRMPVLDGIEATRRLVEGGRAEGTRILGLTTHDTDSYAIRMLRA
                     GAVGFLLKDSTAVQLVDAIRSVHNGTFAASMSTTQRLLERLAVERTAPPDPDTAALDVL
                     TDRERVVFTRLVTGASNPEIARDLSIAEVTVKTHVGHILTKLAVRDRVHLVIWAHRRGL
                     AA"
     gene            complement(8205..9341)
                     /locus_tag="EOG37_RS16085"
                     /old_locus_tag="EOG37_09870"
     CDS             complement(8205..9341)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.5"
                     /locus_tag="EOG37_RS16085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09870"
                     /product="sensor histidine kinase"
                     /protein_id="WP_079533550.1"
                     /transl_table=11
                     /translation="MRRGSLRAQGDQVVAGAAVVLCAIMGVLGQPDWIWSSLMALTLAV
                     RHARPVTAALLATAISSAHMLATSSLLFPGDVVLLVAAYSVAAHAADRLRHVGLALGAC
                     FVVVLAARTLTGGELGSTGSVGMVIALVSVSFAIAWAAGLLERRRSEAVRTAELRTTLS
                     ERDADARTRLAAYEERERISDDMHDVLAHTLTSVIVQAESGRATAPSPEASRMFRTISE
                     TSRAALHEVRGLLAPTDADADVRPIPGWDDVDALVEGFRGSGLGIDRQDAGSPRPLLPG
                     VGFAVYRVVQESLTNAMRHGAGGTARLRVEWSPDALAITVANAVVRDKRGCPVQEHRGL
                     AAIRRRCALYGGQARYACDDEFVLQARWPTAPLGGSTP"
     gene            9703..9909
                     /gene="micA"
                     /locus_tag="EOG37_RS09890"
                     /old_locus_tag="EOG37_09875"
     CDS             9703..9909
                     /codon_start=1
                     /function="Lantibiotic precursor"
                     /gene="micA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038654.1"
                     /locus_tag="EOG37_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09875"
                     /product="lantibiotic michiganin-A"
                     /protein_id="WP_012038654.1"
                     /transl_table=11
                     /translation="MNDILETETPVMVSPRWDMLLDAGEDTSPSVQTQIDAEFRRVVSP
                     YMSSSGWLCTLTIECGTIICACR"
     CDS_motif       9703..9843
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNDILETETPVMVSPRWDMLLDAGEDTSPSVQTQIDAEFRRVVSPYM"
                     /locus_tag="EOG37_RS09890_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9844..9909
                     /prepeptide="core"
                     /locus_tag="EOG37_RS09890_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.60"
                     /molecular_weight="2109.5"
                     /monoisotopic_mass="2108.0"
                     /core_sequence="SSSGWLCTLTIECGTIICACR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNDILETETPVMVSPRWDMLLDAGEDTSPSVQTQIDAEFRR
                     VVSPYM"
                     /leader_location="[9702:9843](+)"
                     /alternative_weights="2127.5"
                     /alternative_weights="2145.5"
     gene            10001..13162
                     /locus_tag="EOG37_RS09895"
                     /old_locus_tag="EOG37_09880"
     CDS             10001..13162
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EOG37_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09880"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_220015537.1"
                     /sec_met_domain="DUF4135 (E-value: 7.2e-91, bitscore:
                     300.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.4e-44, bitscore:
                     147.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITAAELSLLQASRLRERRAATRADARPVPELTRAWRDDALVDD
                     GTHAAYLAGQLLDGDDLVALLAGDAWTPRAASADWLARVDPWLVHPPVSAEAYATANGH
                     LVVEDTRVAGLPFAALLGPMVGAQRAHLDGRPWLSRTATADLLDGLAERLATLSLRALL
                     AERARDPAPGRHARLDARLADPAHRAELLSRHPVLARDLVTAIGSWRAHVARILDRLHA
                     DHGDLVRMGLAPERLDALEAVDLSSGDPHDGGQSVATLRFSDGSRLVYKPRDCRVFALY
                     RDLVDALAPALPAEIRLRAAAVLPRDGYGWVEFVAHAEDAASAIPLSRHLGRLGSLLAV
                     AHVLGASDLHLENVIASADGPVPIDLETLIQNRSEVDGEDGTALRRASRMLNASVLGSG
                     ILPVQLTTGEGTSIDVSVSTGGLHGAGTTATVHQVVDAATDRMRIEAREMPVGRSRNQP
                     PGATLARIRSGRAALADGYERTFRAIVERRAEVRAILSAAPDISSRHIVRATRSYSLLL
                     TEMRRPRPLRSGIDRDHLLRHLWTRVEEHPADAALVEAEERALWRLDVPLFSTRMDARA
                     LIADDEEVGPQRFARSTREDVLDRLARLTLDDLPESLRLVDESVLAATATPDGDDDARD
                     DARGRQAADATASLARAPRVDDDALREAARGQARILLASAVLGRDDATWIGVSSSLDSS
                     GLEYRPAGPTLYDGLAGIAFAATHAHGVLPGLGLDDLAGRAMHAVTAILDDWTRGLIDL
                     PVGAYSGATGLLHALAHHDARVGGDGHRDLRAAAVRRLGEVAHEDPHLDVMAGVAGACA
                     VVAGLPEGATEAGRHALRALAGRLMSTAVEVEGGALVWETGAERARLGGFSHGASGVGW
                     ALARTAGVLGDEAIADAAVRALRFDDALFDPSRRRWRDARPEARSAAGSFPAHWCHGTA
                     GIAMARADAAATLDRPDLLELALVGARETASDTLPSDDSLCHGTLGNLIAVRGATRRTG
                     VDPGLAEFRDRALQRVLRAGPRSGLPEGVTSVRGLMLGTSGALYALCRELEPGIPDALL
                     LEGPR"
     gene            complement(13227..14537)
                     /locus_tag="EOG37_RS09900"
                     /old_locus_tag="EOG37_09885"
     CDS             complement(13227..14537)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038656.1"
                     /locus_tag="EOG37_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09885"
                     /product="DUF2510 domain-containing protein"
                     /protein_id="WP_220015538.1"
                     /transl_table=11
                     /translation="MPDVPSAAPAGWFPDGSGQLRYWDGSAWTQHVAPMVQPAAAQAPA
                     PSAAATAAVAASQQADAVRNAQAAEAAHDKAMRASEAAQGKAVRAAEAEQQRATKLAQR
                     EAAMQARAAEREEAARDKSARAAAATATMPVPSRQAATAAPVTPASPASVITDTRPSRH
                     PATTWVVTSVVALAVLIITALGGFGGMFVSLGLVGIATALYPYATGRRSWIPILTTRSR
                     NGVAALGAAVLIVIGATVPVAASAPAPRQAEAISASASPTPSASPTPTATPTPVVHVVE
                     DVNTKTATDARTLLREAGYVVQYVLESGEATSVTDGMTVKSQSPVAGSRTDAGSTVTLT
                     LLAPAPTPTPEPTVAPTVAPAPQPAAPAPAPVAPAPAPAPAAPAPAPAPAPAPGRTITP
                     GAFCKKTEVGSVEKSDTGKSYRCGPDADGQRNRWYPM"
     misc_feature    complement(14836..14852)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.98"
                     /tool="antismash"
     misc_feature    14836..14852
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.1"
                     /tool="antismash"
     CDS             complement(14903..15067)
                     /gene="allorf_782985_783149"
                     /locus_tag="allorf_782985_783149"
                     /protein_id="allorf_782985_783149"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTFSDQICANISAVCPLLQRLSLAYMFLPCHFQKLGRSTWIQSAA
                     RLRPVALAA"
     CDS_motif       complement(14990..15067)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTFSDQICANISAVCPLLQRLSLAYM"
                     /locus_tag="allorf_782985_783149_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14903..14989)
                     /prepeptide="core"
                     /locus_tag="allorf_782985_783149_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.90"
                     /molecular_weight="3084.6"
                     /monoisotopic_mass="3082.7"
                     /core_sequence="FLPCHFQKLGRSTWIQSAARLRPVALAA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTFSDQICANISAVCPLLQRLSLAYM"
                     /leader_location="[14989:15067](-)"
                     /alternative_weights="3102.7"
                     /alternative_weights="3120.7"
     misc_feature    15041..15057
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.96"
                     /tool="antismash"
     misc_feature    15048..15061
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.13"
                     /tool="antismash"
     misc_feature    complement(15049..15062)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.56"
                     /tool="antismash"
     misc_feature    15049..15063
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.69"
                     /tool="antismash"
     gene            15061..16338
                     /locus_tag="EOG37_RS09905"
                     /old_locus_tag="EOG37_09890"
     CDS             15061..16338
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EOG37_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EOG37_09890"
                     /product="HEPN domain-containing protein"
                     /protein_id="WP_220015539.1"
                     /transl_table=11
                     /translation="MSYSTKVLHSELAHFDEFMSLVKAEPALETFLNWNPSDDKRWLEH
                     VFEIQVADLPLQMAERHIAVKGFRADSNLLCELGIALLSWWQNEELDIEIMIPILNVNF
                     EASGFELSANKARVEKLSADMQLARWPGHPTVNAYADIIMMSTHAVVIRGWSLVNESAG
                     SWLRAPDGPPADVPEVPLFFQALRATSDAPTGYVQVMYRPIGWAHRYRGSLPVIEHGPL
                     VDMASKLLQPNIEPVGFLNKSRVETLQAYYSSLEQTGGSIAIAAQRLFESELRERDADR
                     ILDLCIGIEALVAGNPGDATYKIMIRSAAVLARRGLGPASEVMRAAKTIYAYRSSVVHG
                     RGKSQRSENLTLDGQRLSAVDGARLILRELLRARLEDPDIDSDRIDVDIIARALDSWLD
                     QPQEEATGVRRGAKSGPAQTNQTTTD"
     misc_feature    15226..15228
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15292..15294
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15439..15441
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15724..15726
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15880..15882
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16159..16161
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(16374..16559)
                     /gene="allorf_784456_784641"
                     /locus_tag="allorf_784456_784641"
                     /protein_id="allorf_784456_784641"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGQRAVAQLGSALDWGSRGRRFKSCQPDGHASEGPNGPSEAFFVK
                     RAYRQGAQVLSAQIFI"
     CDS_motif       complement(16527..16559)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGQRAVAQLGS"
                     /locus_tag="allorf_784456_784641_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16374..16526)
                     /prepeptide="core"
                     /locus_tag="allorf_784456_784641_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="5405.0"
                     /monoisotopic_mass="5401.7"
                     /core_sequence="ALDWGSRGRRFKSCQPDGHASEGPNGPSEAFFVKRAYRQGAQV
                     LSAQIFI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGQRAVAQLGS"
                     /leader_location="[16526:16559](-)"
                     /alternative_weights="5423.0"
                     /alternative_weights="5441.0"
                     /alternative_weights="5459.0"
                     /alternative_weights="5477.1"
     tRNA            complement(16477..16550)
                     /anticodon=(pos:complement(784596..784598),aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EOG37_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EOG37_09895"
                     /product="tRNA-Pro"
     gene            complement(16477..16550)
                     /locus_tag="EOG37_RS09910"
                     /old_locus_tag="EOG37_09895"
     gene            complement(16624..17163)
                     /locus_tag="EOG37_RS09915"
                     /old_locus_tag="EOG37_09900"
     CDS             complement(16624..17163)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038659.1"
                     /locus_tag="EOG37_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09900"
                     /product="hypothetical protein"
                     /protein_id="WP_220015540.1"
                     /transl_table=11
                     /translation="MDQLLSRLDRIAAGRQAGHVIAEDMRDHPWTARAFRWIRWILIAE
                     TIVGATAVAIALTLAEDGVAIAPAVWFRSFVVLAMTLTLYYFAWRASTGYWWAYSRLRL
                     FSQIFPIVTLVVAAIPGLYPLWMVIEQIVFSLLLIGVADILRSDHMRDAFPKPGRVAAS
                     GAPDPSAPGHPGGAPA"
     misc_feature    complement(17137..17151)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(17147..17162)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.44"
                     /tool="antismash"
     gene            17450..18787
                     /locus_tag="EOG37_RS09920"
                     /old_locus_tag="EOG37_09905"
     CDS             17450..18787
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038660.1"
                     /locus_tag="EOG37_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09905"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_220015541.1"
                     /transl_table=11
                     /translation="MTLIDREPRPASGSPAPAHGTANADAPARTDRPRPAPLGDAPVDR
                     WKGAPRPTTPAAWIARAREVADILAVDQVERDRAGASPHQEVALLKHAGLVTLLGPAEH
                     GGGGQTWDTAYKVIRAVARGDGSIGQLLGYHYLWAWAARLVGTDAQIEAVEKLATTGNL
                     LFGGAVNPRDSDLVIREDGDDLIFSGRKSFSTGGVVSDLTVLEGVIEGTETHVFAIVPT
                     DQPGIVFGHDWDSLGQRLTESGSVEILDVRVPWTDAAGFVDKVFQPLVYGTLNVPAIQL
                     VFANFYQGIAEGALETAAAYTRSTTRAWPYGGDDKERATDEWYVLEGYGQLQSKVWASE
                     ALLDRVGAEISAVLHAPREKLTERKRGEIAVRVAAAKARIAEDGLEVGTRILELTGARA
                     SSSKAGLDIFWRNLRTHTLHDPIPYKRREVGRHVLLGEIPEPTWYT"
     gene            complement(18901..20409)
                     /gene="der"
                     /locus_tag="EOG37_RS09925"
                     /old_locus_tag="EOG37_09910"
     CDS             complement(18901..20409)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="der"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038661.1"
                     /locus_tag="EOG37_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09910"
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="WP_043586316.1"
                     /transl_table=11
                     /translation="MADHDDDFPELDSGLHERLSSIDEELASQRAQTLRAGLEDYELDD
                     EDLEVLESATDDPDQVTYLPALPVLAVVGRPNVGKSALINRILGRREAVVEDTPGVTRD
                     RVSYKAEYAGRWFTLVDTGGWEPDAKGINASVAMQAEIAMDLADAVLFVVDANVGATST
                     DEHVVRLLRKTKKTVILAANKVDDARQEPNAASLWSLGLGEPHPVSALHGRGVADLLDL
                     VLKTLPLVSKVAKEEVGGPRRVAILGRPNVGKSSLLNKAAGEERVVVNELAGTTRDPVD
                     EQVEIAGKVWRFVDTAGIRRRMHLAQGADFYASLRTSAALEKAEVAVVMIDVSEVISEQ
                     DIRIIELVLESGRALVLAFNKWDLLDDERRRYLEREIETDLAHVSWAPRVNISARTGRH
                     MEKLVPALETALESWDTRIATGKFNAFLAELTAAHPHPVRGGKQPRILFGTQASSRPPT
                     FVLFTTGYLDPQYRRYIQRRLREIYGFEGSPIIVNMRVREKRKR"
     gene            complement(20449..21177)
                     /gene="cmk"
                     /locus_tag="EOG37_RS09930"
                     /old_locus_tag="EOG37_09915"
     CDS             complement(20449..21177)
                     /EC_number="2.7.4.25"
                     /GO_function="GO:0004127 - (d)CMP kinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="cmk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038662.1"
                     /locus_tag="EOG37_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09915"
                     /product="(d)CMP kinase"
                     /protein_id="WP_227266445.1"
                     /transl_table=11
                     /translation="MTGDTTPAPDPLEDTVLVDATLNRTVVAVDGPAGSGKSSVSRAAA
                     RALGFDYQDTGAAYRALSWFALESGVDTEDPATVTSLIEGFDYDIAIDPSETRVSVRGT
                     DVTEAIREPRVSAVVSRVARVPEVRHYMVELFRSLMASSDKPGIVVEGRDITTVVAPDA
                     QVRILLTASPEARMSRRSAETSTQSAAAVGESLASRDRADSQVVDFMNAADGVTTIDST
                     DIDFDQTVQAVVDLVHARTD"
     gene            complement(21174..22292)
                     /locus_tag="EOG37_RS09935"
                     /old_locus_tag="EOG37_09920"
     CDS             complement(21174..22292)
                     /EC_number="1.3.1.12"
                     /GO_function="GO:0004665 - prephenate dehydrogenase (NADP+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0008977 - prephenate dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_process="GO:0006571 - tyrosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012298649.1"
                     /locus_tag="EOG37_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09920"
                     /product="prephenate dehydrogenase"
                     /protein_id="WP_220015542.1"
                     /transl_table=11
                     /translation="MSEAAGAAAATDTRVQGTVRIVGTGLLGTSIALGLRARGVDVVLA
                     DASPTTLRLAADMGAGRIADIGAAPDRPSLVVVCVPPDVTARVVAAELAAHPDALVTDV
                     ASVKAAPLAELAAMGADLSRYLGSHPLAGRERGGPVSATGDLFLGRPWVIAGHDGITYA
                     AGAPVEQLILDLGAVPIEMTAEEHDASVALVSHVPQVVASLLASRLADGDAAALGLSGQ
                     GLRDTTRIASSDAALWVQILGANASRIVPILKALRIDLDEVIEALDDVDARGSRLRVAE
                     RIHAGNAGVARIPGKHGQDRRFAAVTVMIDDRPGQLAALIDDVGAADVNIEDLRLEHSQ
                     GAQVGLVEIAVLPEARDRLVARLEERNWRIAG"
     gene            complement(22289..23143)
                     /locus_tag="EOG37_RS09940"
                     /old_locus_tag="EOG37_09925"
     CDS             complement(22289..23143)
                     /EC_number="5.4.99.-"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1154: Pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012038664.1"
                     /locus_tag="EOG37_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EOG37_09925"
                     /product="pseudouridine synthase"
                     /protein_id="WP_220015543.1"
                     /transl_table=11
                     /translation="MTPSSDHAWNPDEPVQGVRLQKVMAAAGVASRRVCEDMIAAGRVT
                     VNGEVVTEPGRRIDPDVDEVAVDDQAVQLDTSKRYLMLNKPVGIYSSLRDERGRPDLRE
                     FTEEFEERLFNVGRLDAETSGLLILTNDGDLAHVLAHPSFGVLKTYIAKVTGRVTLQTI
                     QRLTQGVDLEDGPIQADRARILSGGGDQTLVEITLHSGRNRIVRRMLDEVGHPVEELVR
                     RQFGPLHLGSLGVGRVRDLTSDELGQLLTISREARAQAGPATPQGAGAAAEAQGDVDRE
                     DGE"
ORIGIN
        1 cccgcgtgta ggcggaggcc ggcgacgcga gcacgcgcgc ggccggtccc gtctcctgca
       61 cgcggccgcg ctgcatcacg accacctcgt cggcgcgctc ggcggcgacc gccaggtcgt
      121 gcgtgatcat cagcagcccc gcgccggtct cctcccggag ccggtcgagg aggtcgagca
      181 cgcggcgctg cacggtcacg tcgagggcgc tcgtgggctc gtcggcgatg atcagctccg
      241 gctcgagcgc gatcgccgcg gcgatgagca cgcgctggcg catgccgccg gagagctcgt
      301 gcgggtgctg ccgggcgcgc gtctccgggt cgtcgatgcc gacgcgctcg aggaggtcga
      361 gcacgcgggc gcggttccga cggcggtcgc gggatccgtg gatccgcagc ccctcggcga
      421 cgctcgcccc gatggtggcc acggggtcga gggagctgcc cggatcctgc ggcacgagcc
      481 cgatgcggcg cccgcggatg ccgcgcagcc gcgactcccc gatgccgacc agctccgtgc
      541 cgccgagcgc gatgccccct cccgcgatgg tgccgttgcg ggcgaggagc ccgaccacgg
      601 cctgcgcgac ggacgacttg ccggacccgg actcgccgac gagcgccgtg acacgccccg
      661 cggtgatctc gaaggagacg ccgtcgaccg cgcggcgggt gcccgccgcc gtccggtagt
      721 ccacctgcag gtcgcgcacg gcgaggagcg gatgcgtggg atcggtcatg cgagctgccc
      781 tccgcggatc gactggctga tgcggttggt cgcgagcacg acggccacga ccacggcgcc
      841 cgggagcacc gtgagccacc acgcggtggc cacgtagtcg cggccctccg cgacgagcag
      901 gccccactcg ggcgtgggcg gcggggcgcc gtagccgagg aagccgagcg tggagatctg
      961 caggatcgcg gatccgaact ggagggccgc gagcgcgatc acgggcgtga gcgagttcgg
     1021 cagcacgtgc cggcgcagca cctgcacgag ggtgccgccg gatccgtacg ccgcctcgac
     1081 gtactcgctg atccgcacgc gcaccacctc cgcccgcgac agccgcgcga acacggcgat
     1141 ggacgtgaca cccaccgcga tcgcggcgtt cgtggtgccg aagcccagca ggatcacgat
     1201 gctcaagctg agcagcaggc ccgggatcgc gagcagcacg tcgacgagcc gcatgagcac
     1261 gtcgtcgacg atgccgccga ccgtgcccgc gaccacgccg aggagcgtgc cgacgacgag
     1321 accgacgagc accgcgacga ccgcgccgac gaccgactgc gacgccccga acacgacgcg
     1381 cgtgtagagg tcgcggccgg tggagtcggt gccgaaccag tgcgcggcgc tcggcgcctg
     1441 cagcgacggc gccacggacg cggtcgggct gccggacgcg aagaggccgg ggacgagcgc
     1501 ccacagcagc atcacgagca cgacgaggac aggaatcacg aggccgcctg cgaggcgcgc
     1561 ccggctgcgg ggacgcgcgc ggggcgcgtc gatggtggcg agcgtggcgc tcatcgcgca
     1621 cctcctctgc gcaggcgcgc gtcgagaacg gggtagagca ggtcgaccgc gaggttgatc
     1681 acgacgtagg cgaccgtgga gagcacgacg accgcgagca gcaccgggct gtcgcggctc
     1741 gcgaccgcct gcacggtgag ctggccgacg cccgcgcggc cgaagacggc ctcggtgacg
     1801 accgccccgc cgacgagctc gccgaacagc agcccggcca tcgtcagcgt gggcagcagc
     1861 gcgttccggc cgacgccgtg cagcagcagc cacggcgtgt cggcgccgcg ggcccgcacc
     1921 acctcgacga acggcatggc cgacacgtcg tcgatgctgc ggatgagcac ctgcgcgagc
     1981 ggcgccgcga tcggcacggc gatcgtgagc accggcagga tcagcgcctc gccggggctc
     2041 gcgccgatga tcggcaccag cccgagccgg aacgacagca cctggatgag gatgatcccc
     2101 acccagaaca cgggcagcga gacgagcagc ggcggcaggt cgcggaagac ccgacggatc
     2161 cacctggcac cgccgtacgt cgcgaggaac gcgatcggca cggccagcac cacggcgacc
     2221 aggaggccga gcaccgcgag cacgagcgtc gacgggatcg cggtggcgag cagcgtcgac
     2281 acggccgcgc cgctctgcac cgagtacccg agctgcccct gcgcgaacgc ggcggcggac
     2341 tcgccgagcc gcacgatcag cggccggtcg gcaccgtagg actcgcggat cgcggcgagc
     2401 tgctccggcg cgaggccgag ctccgggctg ccgtagcggg cgagcaccgc gtcgccgggg
     2461 agcgccgcga gcagcacgta cgccacgacg taggcgagga cgagcactat gactgcctgg
     2521 ccggcgcggc ggatggcgta gctcatcgcg gtcccccgcc cctcgtcaga ggaaggacgc
     2581 gccgcatcag cggtcgagcc agacgcccgc gaagacgggg cggccgaccg actcggtggc
     2641 gaagccccgc acgtcgccgc ggaggccgta gacctgcggc tcctcgaaca gcggcagcac
     2701 gtaggcctgg tcggcgatgc gctgctgcgc cgcctccgac gcggcctgcc ggccctccgt
     2761 cgtgggctcc gacgcgatgc gggtgaggag cgcgtccagc tccgggtcgg cgatgctgcc
     2821 gtccgcgggg ttccggttga gcagcacgtt gcggttggtg gaggagtact gcgacttgag
     2881 gacgtcgtag tccgagcggc cgaccatcga gtggtacgcc tcgagcgcgt ccgggtcctg
     2941 cgaggccttc gtctgcgcgg cctggtcgcc cgagaacagc tccacctcca cgccgatctc
     3001 cgcgagctgc gactggatca gcgtcacgac ctccttggag cgcggctgcg ggagcgcctc
     3061 gttgacgacg agctccagct tccgtccgtc cttctggcgg atgccgtcgg atccggggac
     3121 ccagccggcc tcgtcgagga gcgcggcggc cttgtcggcg tcatgcgcgt agtacgagga
     3181 ggtgtcgacg tagccgagcg cgctcttcgc gagcacgccg gtcgcgagcg ggtagctgtc
     3241 gctgaagagg gtgtcgagga tcgcctgccg gtcgacgccc gcgatgatcg cctgccggac
     3301 gcgcacgtcc tcgagctgcg gcgtgcggaa gcggaggttg atgccgttgt cgacgccgtt
     3361 ggtcgccgcc gcgacgagct ggaggtcgcc cgtgcggaac tgcgcctcgt cgggcgcctc
     3421 gatctgccgg gcgacgtcgg cctgcccggc cacgaccgtg ccgacccgca cgctgtcctc
     3481 ggcggcgacg atgaggtcca ccccgtcgac gagcggccgg ccctggtggg cggcctcggg
     3541 cggcgcccag tcgtagtcct cgcgggcggc gagctggatc tgcgtgccca ccgactcccc
     3601 ggacaccgtg aacggcccgc tgccgatgac cgtctccgcc tgcccgggcc cgaaaccgtc
     3661 gtcggccttg gcgagcgtcg agtcggacac gagccccgag ttgatggtcg aggtggcctg
     3721 cgcgaagccg ggcgcgggag ccgtgaagtg gaacctgacg gtgtccgcgt cgacgacctc
     3781 gccgcggtcg tagttgttga tcgcctcgct gacggtgagc gctcggtcga cgtcgccctt
     3841 gccgtagagg tcgaagttcg cgacgacgtt ctgggcggtg agcggggtgc cgtcggagta
     3901 ggtcacgtcg gtgcggatgt cgaacgtgta ctcggtcgcg tcggcgttca cctcgggcag
     3961 cgccgtcgcg atccacggct cgagctcgag cgtctccggg tcctgccaga gcagccggtc
     4021 ggtgatgttg ttgacgacgg cgccgttcgg gtagaagccg gcggccggcg ggtagagcgt
     4081 cgtccaggtc tgcggctcga ggtaggtgag cgtgccgccg gccctcggtt cgccgctcgc
     4141 cgcttgatcc cctccgccgc ccgccgagca cccggccatc agaccggtcg ccgcgacgag
     4201 ggcggtgagg gcgatgacgg ggcggggagg acgaggcatg gttctgctcc tgcgtgtgct
     4261 gtgcgtggat gggtgagacg actccaacac gcatgcaggg tcttcgcagg gccgcggaac
     4321 acgcggcgta acggggtgca acgcggcgtc acgcggggaa tgccacccgc gtgctcgccg
     4381 ttgcggcggc ggcgtgacgc ctcgccgccg tcgactccgc tgccggatgc cgacgccctc
     4441 tagggttccg ggatgaccac gccccccccg tccgccccgc cgtgcccgac gacgccgacg
     4501 ggatcgccga ggtccacatc cgcacctggc aggagacgta cgcgcacctg ctgccggccg
     4561 cgtacctcga cggcctggac gtcgcggcgc gcgccgagca gtggcggggc tcgctgggtg
     4621 acccttccgg ggctccgacc ttcgtcgccc tcgacggcga ccgcatcgtc ggtttcgcgc
     4681 tcgcgggacc ggcgcgcgac gaggatccgc cgcgcccctt ccagctctac gcgatcgacg
     4741 tggtcgcgtc cgcccacggc acgggcgccg gccaggcgct gttcgacgcg gccgtcggcg
     4801 actcccccgc ctacctctgg gccgccgacg acaacccgcg cgcggcggcg ttctaccgcc
     4861 gcaacgggtt cgtgcgcgac gggggcgtcg agcggcagac gtaccagggg gcggagatgg
     4921 tcacggtgcg gatggtgcgg tgagggtgcc ggcgggcggc gcacggcccg gcgcgccgct
     4981 cagcgcagct tgaccacgcg gatcgccgcc agggtgagga ggacgacgag cgcgccgagg
     5041 cccacgctcg tcgcgaggag cggcagggtg tccgccgccg tgaggccccc ggatcccgcg
     5101 atcgccgtcg accccaggtt cagcgcccgg gtgttgatcg cctgcgggag cacctccgcc
     5161 agcggacgca gggccgccga ggtcacggcg gcgacgcccg cgacgcaccc gacgaggcac
     5221 agcgcgaccg gcgccgcgaa ggaccgcagg agcagcgaca gcagggactg gacggcgatg
     5281 aggggcagcg ccgccacggt cgcgatcagc cccacgagga ggaacgcgac ggggaacggg
     5341 ccgtccagcc ggagcacgaa cagcccggac accgccgtgc cgccgacgag caccgcctgc
     5401 atcagcgcca ccggcacgag gatcgccacg atcttcgcca gcacgagccg gatcggtcgc
     5461 gtggtcgccg tcagcagggc gttccagttg gtgccgcggt gctcgacgcg ccagatggcc
     5521 gccgcgagca ggctgatgcc catcgagtag aagagcaggc cgtagaacag caccacctgc
     5581 gaggtgaagg acgcccaccc ggagtccagg gtctgcgtgt tgttcgccag gttgatggtg
     5641 ccggtgacga cggccaggag cggcagcagc accgcgatga tccagatgct ggagcgcttg
     5701 agcttcacgg cctcggctcg gaacacgccc gtcacctctc cacgcggtcg agtcggacgg
     5761 tcgcgagcgc gaaggccgcc gcgaccacga cgaggaagcc ggcgatccac ccgagcgggg
     5821 aggcgacgta gtccacgccc gcgtccgact ggccggcctg cgagatgacg gcgtagtacc
     5881 cccacgggat ggcgcggctc gcgacggacg ggagcaggag ggagaagacg gccaggaagg
     5941 cgcccagcat ccccacgccc acgctgatga gctggttctc gacgcgcgcc gcgagccaga
     6001 cgtgcagcgc gcagaacgcc acgtcgacca ggtagagcag gagcgtgtac agcgcccacg
     6061 gccccacctc gacgggcacc cggatcccgg cggcgtaccc ggcggcgatc acgagcagcg
     6121 attggatcag cacggcgggc acgaggagca ccgcgagggc cacgagcttg gcccggcaca
     6181 gctcccccgc cgtgcgtccc gcgcccgccg cgaggatcca cccgcccgcc tggtgctcga
     6241 tgtcggtctg gcggctcgcg atcaccgcgg tgaggatcgg cgaggtcatc gccgccatga
     6301 gcgtgtagcc gagcaggagc gcggcccagg ggtgcgcgcc cggatcgtcg aagcccgcac
     6361 gcgtgctgcc cgcgaactgc gacgccgagc tcagggcggc gacggccacc accatgccga
     6421 tgagcagcgg gagcgagcgg agccggtgca tcttgcggaa ctcgatcgcc acggcgcgcc
     6481 tcacagctgc cccccgcgcc cggtgatgtc catgaacacg tcctccaggc tctgcggcag
     6541 ccgccgcacc tcgtgcacgg gcacgtcggc cgccacgagc cggcgcacga tgtccgcggt
     6601 ctcgtccttg gagcgggcgc tgagccggat cccctccggg ctcctggccg ccccggcgac
     6661 ctccgccatg gcccggtccg gcgcggacgt ctcgatgacg aggtcgggga tggagtgctc
     6721 gaacagctcg gcgcgcgtgc cctggaagat catccggccg tcggccagga tgccgagcac
     6781 gcccgccatc ttctcgatct cgtcgaggag gtggctggag accatcacgg tgatgccctg
     6841 gccggccagg tccatgagga gggagcggac ctcctcgatg cccgccggat ccagcccgtt
     6901 ggtgggctcg tcgaggacga gcagcgaggg gtcgcgggcg agggccatgg cgatccccag
     6961 ccgctgcttc attccgagcg agtaccggcg caccagcttg tcgcggtgct gcgtgagccg
     7021 cacggtcgcg aacgcccgct ccacctgggc ctccgcgagc ccgagcatgt cgcgcacgat
     7081 ccgcatgttc tcccaccccg tgaggtggcc gtagccggcg ggcgcctcga tcatggagcc
     7141 gatggacggc aggagcccgc cgcgcgtcgc cggcgtgagc cgctggccga acaggtggat
     7201 ctcgcccgac gtgggctgcg tgagcccgag cagcatcttc atggtcgtgg acttgccgga
     7261 gccgttgggc ccgaggaacc cgtacacgga cccctgcggc acctcgatgt cgagcgcatc
     7321 gacggcgacg tgatcccgga accgcttggt gagcccgcgg gtggcgatga cggcgctcat
     7381 cggcgcgggg gtgtcgtggt cggcatgccc ccatactcgg ccggccgccg cgcgggcgca
     7441 tcgtgccgtg ggccggtccc gcccggtccc ctctcctgcg atgggaggag cgggtggcag
     7501 gtcggcggga ccgcgcccca tgcgccgcag cggtcaggcg gcgaggcccc gccggtgcgc
     7561 ccagatcacc aggtggacgc ggtcgcgcac ggcgagcttg gtgaggatgt gcccgacgtg
     7621 cgtcttcacc gtgacctccg cgatggacag gtcgcgggcg atctccgggt tggacgcgcc
     7681 cgtgacgagg cgcgtgaaca cgacccgctc ccgatcggtc aggacgtcga gcgcggcggt
     7741 gtccgggtcg ggcggcgccg tcctctcgac ggccagccgc tcgaggagcc gctgcgtggt
     7801 gctcatcgag gcggcgaacg tgccgttgtg cacggaccgg atcgcgtcga ccagctgcac
     7861 ggcggtgctg tccttcagca ggaagccgac ggcgccggcg cgcagcatcc ggatggcgta
     7921 ggagtccgtg tcgtgggtgg tgagccccag gatccgcgtc ccctcggcgc gcccgccctc
     7981 cacgagccgg cgggtcgcct cgatgccgtc gaggaccggc atgcggacgt ccatgagcac
     8041 cacgtccggg cggagctcga cgacgcgggc gacggcctgc tcgccgtccg cgcagacgcc
     8101 gaccgcggcc atgtccggct gcgcgtccac gatgcgggcg aagccatccc gcacgaggga
     8161 ctggtcgtcg accacgacga cccggatcgg cgcgggcgcg tcggtcacgg ggtgctcccg
     8221 ccgagcggcg cggtcggcca ccgcgcctgg aggacgaact cgtcgtcgca cgcgtaccgg
     8281 gcctgcccgc cgtagagcgc gcagcgacgg cggatcgcgg cgaggccccg gtgctcctgc
     8341 acggggcatc cccgcttgtc gcgaaccacg gcattggcga cggtgatcgc cagcgcgtcg
     8401 ggcgaccact cgacgcggag gcgcgcggtg ccgcccgcgc cgtgccgcat ggcgttcgtg
     8461 agggactcct gcacgacccg gtagacggcg aagcccacgc ccggcaggag gggtcgcggc
     8521 gagcccgcgt cctgcctgtc gatgccgagg ccggagccgc ggaagccctc gacgagggcg
     8581 tcgacgtcgt cccagccggg gatgggacgc acgtccgcgt cggcgtcggt gggcgccagg
     8641 agcccccgca cctcgtgcag ggcggcccgg ctggtctcgg agatggtgcg gaacatgcgc
     8701 gacgcctcgg ggctcggcgc ggtcgcccgg ccgctctccg cctggacgat gacgctggtc
     8761 agagtgtgcg ccagcacgtc gtgcatgtcg tcgctgatgc gctcgcgctc ctcgtaggcg
     8821 gcgagccgcg tccgggcgtc cgcgtcgcgt tcggacagcg tcgtccggag ctcggcggtg
     8881 cggacggcct cgctgcggcg ccgttcgagc agaccggccg cccacgcgat cgcgaagctc
     8941 acggacacga gcgcgatgac catgccgacg gatcccgtcg agcccagctc cccgccggtg
     9001 agggtgcgcg cggcgaggac gaccacgaag cacgcgccga gggcgagccc gacgtgccgg
     9061 agccggtccg cggcgtgggc ggcgacggag taggccgcca ccaggagcac gacgtcaccc
     9121 gggaacagga gcgagctcgt cgcgagcatg tgcgccgacg agatcgccgt agccagcagc
     9181 gcggcggtga cgggccgcgc gtggcgcacc gcgagcgtga gcgccatgag ggacgaccag
     9241 atccagtcgg gctggcccag gacgcccatg atggcgcaca ggactaccgc agcgcccgcg
     9301 acgacctggt cgccttgcgc gcgcagactc ccccgtcgca tcacgtcctc aggctagcgg
     9361 ggaggacacg cccggccgcc ggcggacgcc ctccccccgg ccccccgtcc gcggggcatc
     9421 ccggtcgcgg cctccgacga tgggcggagg gcacggccgc ggatgtcatc gggtcgcacg
     9481 atgcgctcgg acggaagccg ctgggaacgt gaacaccagg gatcgcgcac gggctgcgcg
     9541 tcgacgccgc accggccgag gcgcacggat ccgcgatccc cacggggcaa gtcggacctg
     9601 tgacggccca tgggccatcg ggatgggtgc ggctcgcacc acgacggtct gggccgaccg
     9661 gccgggatcc atgcgcgaca acaggaacac aggtggaaca cgatgaacga catcctcgag
     9721 acggagaccc ccgtcatggt cagcccccgg tgggacatgc tgctcgacgc gggcgaggac
     9781 accagcccgt ccgtccagac ccagatcgac gcggagttcc gtcgcgtcgt gagcccgtac
     9841 atgtccagca gcggctggct ctgcacgctc accatcgaat gcgggacgat catctgcgcg
     9901 tgtcgctgac ggacgccctc gacggacggg ccgcgctcgg cgcgcggtcc gtccgctccg
     9961 cgtcgggccc cgcccgccgg agcggcgagg gggatccgac gtgacgatca ccgcggccga
    10021 gctctcgctg ctgcaggcgt cccggctgcg cgaacggcgc gcggcgacgc gggccgatgc
    10081 ccgaccggtc cccgagctga cgcgtgcctg gcgcgacgac gccctcgtcg acgacgggac
    10141 gcacgccgcc tacctcgccg ggcagctgct ggacggcgac gacctcgtgg cgctcctggc
    10201 gggcgacgcg tggaccccgc gggccgcgag cgcggactgg ctcgcccggg tcgacccctg
    10261 gctcgtgcat ccgcctgtct ccgcggaggc ctacgcgacg gcgaacggcc acctcgtcgt
    10321 cgaggacacc cgcgtggctg ggctcccctt cgccgccctg ctcggcccga tggtcggcgc
    10381 gcagcgggcg cacctggacg gtcgcccgtg gctctcgcgc accgcgaccg cggatctcct
    10441 cgacggcctc gcggagcgcc tcgcgaccct ctccctccgg gccctcctcg cggagcgcgc
    10501 ccgggatccg gcaccgggtc ggcacgcgcg gctggatgcg cggctcgccg accccgcgca
    10561 ccgcgccgag ctcctctccc gccaccccgt cctcgcgcgc gacctcgtca cggcgatcgg
    10621 cagctggcgc gcgcacgtcg cgcgcatcct cgaccgcctg cacgccgacc acggcgacct
    10681 cgtccggatg ggcctcgcgc ccgagcggct cgacgccctg gaggccgtgg acctgagctc
    10741 gggcgacccc cacgacggcg ggcagtccgt cgcgacgctg cgcttctccg acggcagccg
    10801 gctcgtctac aagccgcgcg actgccgggt gttcgcgctg taccgcgacc tcgtcgacgc
    10861 gctcgcgccc gccctccccg ccgagatccg cctgcgcgcg gccgcggtgc tgccgcgcga
    10921 cgggtacggc tgggtcgagt tcgtggccca cgccgaggac gccgcctccg cgatccccct
    10981 gtcccggcac ctcggccggc tcggctcgct gctcgccgtc gcgcacgtgc tcggcgcgtc
    11041 cgacctccac ctcgagaacg tcatcgcctc cgcggacggt cccgtgccca tcgacctgga
    11101 gacgctgatc cagaaccgca gcgaggtcga cggcgaggac gggacggccc tgcgccgggc
    11161 gtcgcggatg ctcaacgcgt cggtgctggg cagcggcatc ctcccggtcc agctcaccac
    11221 cggggagggc acgagcatcg acgtcagcgt cagcaccggg ggcctccacg gcgcggggac
    11281 caccgcgacc gtccaccagg tggtggacgc ggccacggac cgcatgcgca tcgaggcgcg
    11341 cgagatgccg gtcggccggt cgcgcaacca gccgccggga gcgacgctcg cgcgcatccg
    11401 ctccggtcgc gccgccctcg cggacgggta cgagcgcacc ttccgcgcca tcgtcgagcg
    11461 ccgggcggag gtccgcgcga tcctgtcggc cgcgcccgac atctcgtcgc ggcacatcgt
    11521 gcgcgccacc cgctcctact ccctgctcct cacggagatg cgccgacccc gcccgctccg
    11581 cagcggcatc gaccgggacc acctcctccg ccacctctgg acgcgcgtcg aggagcatcc
    11641 cgcggatgcc gcgctggtcg aggcggagga gcgcgccctc tggcggctcg acgtgcccct
    11701 gttctccacg cgcatggacg cacgcgccct catcgccgac gacgaggagg tcgggccgca
    11761 gcgcttcgcg cggagcacgc gcgaggacgt gctcgaccgg ctcgcgcggc tcaccctcga
    11821 cgacctcccc gagtccctcc ggctggtcga cgagtccgtg ctggcggcga ccgcgacgcc
    11881 cgacggagac gacgacgccc gcgacgacgc gcgaggacgg caggccgcgg acgccaccgc
    11941 ctcgctggcc cgcgcaccgc gggtggacga cgacgccctg cgggaggcgg cacgcggaca
    12001 ggcccggatc ctcctcgcct ccgccgtcct cggccgggac gacgcgacct ggatcggcgt
    12061 gagcagcagc ctcgacagca gcggcctcga gtaccgcccc gcggggccca ccctgtacga
    12121 cgggctggcc gggatcgcgt tcgccgcgac ccacgcgcac ggcgtgctgc ccggcctcgg
    12181 gctcgacgac ctggccggcc gggcgatgca cgcggtcacg gcgatcctcg acgactggac
    12241 gcgcggcctg atcgacctgc cggtgggcgc ctacagcggc gcgaccgggc tcctccacgc
    12301 gctcgcccac cacgacgcgc gggtcggcgg cgacgggcac cgcgacctcc gggcggcggc
    12361 cgtccgacgg ctcggcgagg tggcccacga ggatccgcac ctggacgtga tggcgggcgt
    12421 cgccggcgcg tgcgccgtcg tcgcggggct gcccgagggc gcgaccgagg cgggccgcca
    12481 tgcgctgcgc gcgctcgcgg ggcggctgat gagcacggcg gtcgaggtgg agggcggcgc
    12541 cctcgtctgg gagaccggtg ccgagcgggc gcggttgggc gggttctcgc acggcgcatc
    12601 cggcgtcggc tgggcgctcg cccgcaccgc cggcgtgctg ggcgacgagg cgatcgccga
    12661 tgcggccgtc cgcgccctgc gcttcgacga cgcgctgttc gacccgtccc gccgccgctg
    12721 gcgcgacgcg agaccggagg cgcgatccgc ggccggatcc ttccccgcgc actggtgcca
    12781 tggcaccgcg ggtatcgcga tggcgcgcgc ggacgcggcc gcgacgctcg accggccgga
    12841 cctcctcgag ctcgccctcg tcggggcgcg cgagacggcg tcggacacgc tcccctccga
    12901 cgactccctg tgccacggga cgctcggcaa cctcatcgcc gtgcgcggcg cgacccgacg
    12961 caccggcgtc gaccccgggc tcgcggagtt ccgcgaccgc gcgctgcagc gcgtcctccg
    13021 cgcaggcccg cgcagcggtc tgcccgaagg ggtgaccagc gtgcgggggc tcatgctcgg
    13081 cacgtccggc gcgctctacg cgctgtgccg ggaactggag ccggggatcc cggacgcgct
    13141 cctgctggag gggccgcgct gacggtcgcc ccggttgttc gcgcggggtg gcccgggcag
    13201 ccgtcgtggg gccgcccggg ggtcggtcac atcgggtacc agcggttgcg ctgaccgtcg
    13261 gcgtccgggc cgcatcggta gctcttgccc gtgtcggact tctcgacgct gccgacctcg
    13321 gtcttcttgc agaaggcacc gggcgtgatc gtccggcccg gggcgggggc gggagccggg
    13381 gcaggagccg gggcggcagg agccggtgcg ggggcaggcg cgacgggcgc cggagcggga
    13441 gccgccggct gcggcgcggg cgccaccgtc ggcgcgaccg tgggctcggg cgtcggcgtc
    13501 ggtgcgggcg ccagcagcgt gagcgtcacg gtggatccgg cgtcggtgcg cgatcccgcg
    13561 accgggctct gggacttcac cgtcatgccg tcggtgacgc tggtcgcctc gcccgactcg
    13621 agcacgtact gcacgacgta gccggcctcg cggaggagcg tccgggcgtc ggtggcggtc
    13681 ttcgtgttga cgtcctcgac gacgtggacc acgggggtcg gcgtcgcggt gggtgtcggg
    13741 ctcgcagacg gggtcgggct cgcgctggcg gagatcgcct ccgcctggcg cggagcggga
    13801 gcggacgccg cgaccgggac cgtggccccg atgacgatga gcacggccgc gcccagggcg
    13861 gcgacgccgt tacgcgaacg ggtcgtcagg atcgggatcc agctgcgacg gcccgtggcg
    13921 taggggtaga gagccgtggc gatcccgacg aggccgagcg agacgaacat gcctccgaag
    13981 ccgccgaggg cggtgatgat cagcacggcc agcgcgacga cggacgtgac gacccacgtg
    14041 gtcgccgggt ggcggctcgg ccgggtgtcg gtgatcacgg aggcaggaga cgcaggggtg
    14101 accggcgcgg cggtggcagc ctgtcgcgac gggaccggca tcgtcgcggt cgccgcagcc
    14161 gcccgggcgc tcttgtcccg agccgcctcc tcgcgctccg cggccctcgc ctgcatggcc
    14221 gcctcgcgct gtgcgagctt cgtggcgcgc tgctgctccg cctcggcggc acgaacggcc
    14281 ttcccctgcg cggcctcgga agcacgcatc gccttgtcgt gcgcggcctc ggcggcctgc
    14341 gcgttccgca cggcgtcggc ctgctgcgac gcggcgacgg cggccgtcgc ggctgcgctc
    14401 ggagcgggtg cctgcgctgc ggccggctgc accatcggcg cgacgtgctg cgtccatgcg
    14461 gatccgtccc agtagcggag ctggcccgat ccgtcgggga accagccggc gggagcggcg
    14521 gaggggacgt cgggcatgga actcctcggg tgcgtgccgc ggcgaagggg taggcggcaa
    14581 gtggcgccgt cgagtgacga cgcctgaggc tatgggcgta ctctcgcggg cgtaagccct
    14641 cgtgtggggg tgaatcggac ccgcgactac tgggatccgt tccccgaccg aaagcggcga
    14701 ctcggcgctt agtctttccg ctttccaaca gcgcgcacgg catccgagag ggatccaccg
    14761 taccgcttcc ggtgctcctt cccaggctca cgtgaccaca tgacgccggc gccaaagctc
    14821 gctaggcttt aaatcatgcg atttactaac agtacgcggg ataaattatt ggcttccgcg
    14881 acacaagtag ccatagatgc cattaggcag ctagagctac tggccgaagc cgggcagcgc
    14941 tttgaatcca cgtactccta cccaactttt gaaagtggca gggaaggaac atataagcga
    15001 gtgacaaccg ctggagcagc ggacacaccg cggagatatt cgcacatatt tggtccgaaa
    15061 atgtcatact ccacaaaagt cctgcattcc gaacttgccc attttgatga gttcatgagc
    15121 ctagtgaagg ccgaaccggc cctcgagacc ttcctcaatt ggaatccgag tgacgacaaa
    15181 cgttggcttg aacacgtttt tgagatccag gttgccgacc tacccttaca aatggccgaa
    15241 cggcatatcg ccgtcaaagg gtttcgtgcc gactctaacc tgctatgtga gttaggaatc
    15301 gcgctactca gttggtggca aaatgaagag cttgacatag aaataatgat acccatactc
    15361 aatgtcaatt ttgaagcgtc gggcttcgaa ttgtccgcga ataaagctcg cgttgaaaag
    15421 ctctccgccg atatgcaatt agcgcggtgg cccgggcacc ctaccgtcaa cgcatacgcg
    15481 gacataatta tgatgtcgac tcacgctgtc gtgatccgag gatggtcact tgtaaacgaa
    15541 tcagccggat cctggctgcg cgctcccgat ggcccacccg ccgacgtgcc agaagtacca
    15601 ctgttttttc aagcccttcg tgccacatca gacgcaccga cggggtacgt tcaagtgatg
    15661 tatcgcccta ttggatgggc gcaccgctac cggggctcat tgcccgtcat cgagcacggc
    15721 cccttagtgg atatggcctc taaactactg cagccgaata tcgagcccgt tggattccta
    15781 aacaagtctc gggttgagac gcttcaagca tattactctt ctctagaaca gacaggcggg
    15841 agcatcgcca tagcggcaca aagattgttt gaatcggagt tacgcgaacg agacgcggat
    15901 cgcattctag acctttgtat tggtattgaa gcccttgtcg ctggcaaccc cggtgatgca
    15961 acctataaaa taatgattcg aagtgccgcg gtacttgcaa ggcgaggtct cgggcccgcc
    16021 tcggaagtca tgcgggcggc gaagacaatt tatgcttacc gctcttccgt tgtacacgga
    16081 agaggcaagt cccaaaggtc tgagaatttg acattggatg gtcaacgact atctgcagtc
    16141 gacggtgccc ggcttatttt acgagaactc ctcagggctc gcctagaaga ccctgacatc
    16201 gatagcgata gaatcgatgt ggacataatc gcgcgggccc tagacagttg gctggaccag
    16261 ccccaggaag aagccactgg cgtgcgtcgc ggcgcgaaat ctggccctgc gcaaactaat
    16321 caaacaacca cagattaggt atgaaaatat ccctaaagaa aaaggaatat cactcatatg
    16381 aaaatttggg ctgaaagtac ttgcgctccc tgacggtagg cacgctttac aaaaaatgcc
    16441 tcggaaggac cattgggtcc ttccgaggca tgtccgtcgg gctgacagga tttgaacctg
    16501 cgaccccttg acccccagtc aagtgcgcta ccaagctgcg ccacagcccg ctgtcccatc
    16561 gctgggcaac tcgtagagcc taccgcatcg gcggcactgc tccggcacgc acgaggtccc
    16621 ggatcaggct ggcgcaccac ccgggtgacc cggagcggag gggtcaggcg caccggaagc
    16681 agccacccgc cccggcttcg ggaacgcgtc ccgcatgtgg tcgctccgca ggatgtcggc
    16741 caccccgatg agcagcagcg agaagacgat ctgctcgatg accatccaga gcgggtagag
    16801 gcccgggatc gcggcgacca cgagggtcac tatcgggaag atctggctga agaggcgcag
    16861 gcgcgagtac gcccaccagt agcctgtcga ggcgcgccag gcgaagtagt agagcgtgag
    16921 ggtcatcgcg agcaccacga aggagcggaa ccagacggcg ggggcgatcg cgacgccgtc
    16981 ctcggcgagg gtcagggcga tggcaacggc ggtcgcgccc acgatggtct cggcgatgag
    17041 gatccaccgg atccagcgga aggcccgcgc cgtccacggg tggtcgcgca tgtcctcggc
    17101 gatgacgtgg cccgcctggc gcccggcggc gatccgatcg agacggctga gcagctggtc
    17161 caccggtgcg atcctccgtg tctcgtgagc gggcgtcgga tgcgcccgga tcagggtacg
    17221 acgtgacgcc tggagccgcc cgcgaacgtg gggagcagcg cgatccggac aggcgacgcg
    17281 ggcaccagcc ggcggtcggc ggatcccccg catgacggcc cgtgacgccc cgcgtcgtca
    17341 caccccgcaa ccccgcgtca cacccctcgc cagcccgccg gacccgcccc taccgttgcc
    17401 ccaccgcgag gcgcggcacc ggtcgcgccc cttcacgaga ggacaggaca tgaccctgat
    17461 cgaccgcgag ccccgacccg catccggctc ccccgcgccc gcccacggca ccgcgaacgc
    17521 ggacgcaccc gcgaggaccg accgcccgcg ccccgctccc ctcggcgacg ctcccgtcga
    17581 ccgctggaag ggcgccccgc gtcccacgac gcccgccgcg tggatcgccc gcgcccgcga
    17641 ggtcgccgac atcctcgccg tcgaccaggt cgagcgcgac cgcgccggcg cgagcccgca
    17701 ccaggaggtc gcgctgctca agcacgccgg cctcgtcacg ctgctcgggc ccgcggagca
    17761 cggcggcggc gggcagacgt gggacaccgc gtacaaggtg atccgcgcgg tcgcccgcgg
    17821 cgacggatcc atcggccagc tcctcggcta ccactacctc tgggcatggg ccgcgcggct
    17881 cgtcggcacg gacgcgcaga tcgaggccgt ggagaagctc gccacgacag gcaacctgct
    17941 cttcggcggc gccgtgaacc cgcgcgactc cgacctcgtc atccgcgagg acggcgacga
    18001 cctgatcttc tccggccgga agtcgttcag cacgggcggc gtcgtgtccg acctcacggt
    18061 gctcgagggc gtgatcgagg gcacggagac ccacgtgttc gcgatcgtgc cgacggacca
    18121 gcccggcatc gtcttcggcc acgactggga cagcctcggg cagcggctca cggagtccgg
    18181 ctcggtcgag atcctcgacg tgcgcgtgcc gtggacggac gccgccgggt tcgtcgacaa
    18241 ggtgttccag ccgctcgtct acggcacgct caacgtgccg gcgatccagc tcgtgttcgc
    18301 gaacttctac cagggcatcg cggagggcgc gctcgagacg gccgccgcgt acacgcgcag
    18361 caccacgcgc gcatggccgt acggcggcga cgacaaggag cgcgcgaccg acgagtggta
    18421 cgtgctcgag ggctacgggc agctgcagtc gaaggtgtgg gcgtcggagg cgctactcga
    18481 tcgggtgggc gccgagatca gcgccgtgct gcacgcgccg cgcgagaagc tcacggagcg
    18541 gaagcgcggc gagatcgccg tgcgcgtcgc ggcggccaag gcgcgcatcg cggaggacgg
    18601 gctggaggtc ggcacgcgga tcctcgagct cacgggcgcg cgcgcctcct cctcgaaggc
    18661 cgggctcgac atcttctggc ggaacctgcg gacgcacacc ctgcacgacc cgatccccta
    18721 caagcgccgc gaggtcggcc ggcacgtgct gctcggcgag atcccggagc cgacctggta
    18781 cacgtgatcc gcagccagcc cccgacgacg gacggcgccg accccgcgag ggatcgacgc
    18841 cgtccgtcgt gctgcacgcg gcagcggaga gggagcgcta gcgcttccgc gctgtgccag
    18901 ctagcgcttc cgcttctccc gcacgcgcat gttgacgatg atcgggctgc cctcgaagcc
    18961 gtagatctcg cgcaggcgac gctggatgta gcggcggtac tgcgggtcga ggtacccggt
    19021 cgtgaagagc acgaatgtcg gcggccggct cgaggcctgc gtgccgaaca ggatgcgcgg
    19081 ctgcttgccg ccgcgcacgg ggtgcgggtg ggcggcggtg agctcggcga ggaacgcgtt
    19141 gaacttgccc gtcgcgatgc gggtgtccca cgactccagc gccgtctcga gcgccggcac
    19201 gagcttctcc atgtggcgtc cggtgcgcgc cgagatgttg acgcgcggcg cccacgacac
    19261 gtgcgcgagg tcggtctcga tctcgcgctc gaggtagcgg cggcgctcgt cgtcgaggag
    19321 gtcccacttg ttgaacgcga gcacgagcgc gcggcccgac tcgagcacca gctcgatgat
    19381 gcggatgtcc tgctcgctga tgacctcgga gacgtcgatc atgacgaccg cgacctccgc
    19441 cttctccagc gccgcgctcg tgcggagcga cgcgtagaag tcggcgccct gggcgaggtg
    19501 catgcggcgg cggatgccgg cggtgtcgac gaagcgccac accttgccgg cgatctcgac
    19561 ctgctcgtcg accgggtcgc gcgtggtgcc ggcgagctcg ttgacgacca cgcgctcctc
    19621 gcccgctgcc ttgttgagca ggctcgactt gccgacgttc gggcggccga ggatggcgac
    19681 gcggcggggt ccgccgacct cctccttggc gaccttggag acgagcggca gggtcttcag
    19741 cacgaggtcg agcagatccg cgacgccgcg gccgtgcagc gcggagacgg ggtgcggctc
    19801 gccgaggccg agcgaccaca gcgaggcggc gttcggctcc tggcgcgcgt cgtcgacctt
    19861 gttggccgcg aggatcaccg tcttcttggt cttgcggagc aggcggacga cgtgctcgtc
    19921 cgtgctcgtg gcgccgacgt tggcgtcgac gacgaacagc acggcgtcgg cgaggtccat
    19981 cgcgatctcg gcctgcatgg cgacggacgc gttgatgccc ttcgcgtcgg gctcccagcc
    20041 gccggtgtcg acgagcgtga accagcggcc cgcgtactcg gccttgtagg agacgcggtc
    20101 gcgcgtgacg ccgggggtgt cctcgacgac ggcctcgcgg cggccgagga tgcggttgat
    20161 gagcgccgac ttgccgacgt tcgggcggcc gacgaccgcg agcacgggca gcgccggcag
    20221 gtacgtgacc tggtcggggt cgtcggtggc ggactcgagg acctcgaggt cctcgtcgtc
    20281 cagctcgtag tcctcgagcc cggcgcggag cgtctgcgcg cgctgggaag cgagctcctc
    20341 gtcgatgctc gacaggcgct cgtggagccc gctgtcgagc tcggggaagt cgtcgtcgtg
    20401 atcagccatg ttgtcctctg gcgtgtcggc ccgtcaccgg gtcgcgcctc aatctgttcg
    20461 tgcgtgaacg agatcgacca ccgcctggac ggtctggtcg aagtcgatgt ccgtggagtc
    20521 gatggtggtc acaccatctg cggcgttcat gaaatcgacg acctgcgagt cggcccgatc
    20581 ccgggaggcg agtgattcgc cgaccgcggc tgccgactgg gtcgacgtct ccgcggaacg
    20641 cctgctcatc ctagcttccg gggaggccgt cagcagaatg cgcacctggg cgtcgggcgc
    20701 gacgaccgtc gtgatgtcgc gaccctcgac cacgatgccg ggcttgtcgc tcgacgccat
    20761 gagcgagcgg aacagctcca ccatgtagtg ccgcacctcg ggcacgcggg ccacgcggct
    20821 cacgacggcg gacacgcggg gctcgcggat cgcctcggtg acgtcggtgc cgcggacgct
    20881 cacgcgcgtc tcggacggat cgatcgcgat gtcgtagtcg aagccctcga tcaggctcgt
    20941 gacggtggcg ggatcctccg tgtcgacgcc gctctccagc gcgaaccagc tgagcgcgcg
    21001 gtacgcggcg cccgtgtcct ggtagtcgaa gccgagggcg cgcgcggcgg cgcggctcac
    21061 gctcgacttg ccgctgccgg cggggccgtc gactgcgacg accgtgcggt tgagcgtggc
    21121 gtccaccagc acggtgtcct ccagggggtc gggtgcgggc gtcgtgtctc cggtcatccg
    21181 gcgatcctcc agttccgttc ttcgagccgc gcgaccaggc ggtcgcgggc ctcgggcagc
    21241 acggcgatct ccacgagacc cacctgcgcg ccctgcgagt gctcgaggcg caggtcctcg
    21301 atgttgacgt cggcggcgcc cacgtcgtcg atcagcgcgg ccagctggcc ggggcggtcg
    21361 tcgatcatca cggtgacggc ggcgaagcgg cggtcctggc cgtgcttgcc ggggatgcgc
    21421 gcgacgcccg cgttgcccgc gtggatccgc tcggccaccc gcagccggga ccctcgcgcg
    21481 tcgacgtcgt cgagcgcctc gatgacctcg tcgaggtcga tgcggagcgc cttcaggatc
    21541 ggcacgatgc gggaggcgtt cgcgccgagg atctgcaccc acagcgccgc gtcgctcgac
    21601 gcgatgcgtg tggtgtcgcg gagcccctgc ccggagaggc cgagcgccgc cgcgtcgccg
    21661 tcggccagtc gcgacgccag gaggctcgcg acgacctgcg gcacgtgcga gaccagcgcc
    21721 accgaggcgt cgtgctcctc ggcggtcatc tcgatgggca cggcgccgag gtcgaggatc
    21781 agctgctcga cgggcgcgcc cgcggcgtac gtgatgccgt cgtggcccgc gatgacccag
    21841 ggccggccga ggaagaggtc gcccgtcgcg gagacggggc cgccgcgctc gcgcccggcg
    21901 agcgggtggg agccgaggta gcgggagagg tcggcgccca tcgcggcgag ctccgcgagc
    21961 ggcgcggcct tcacgctcgc gacgtcggtg acgagcgcgt ccgggtgggc ggcgagctcg
    22021 gccgcgacca cgcgcgcggt cacgtccggc ggcacgcaga ccacgacgag cgacggccga
    22081 tcgggggccg cgccgatgtc ggcgatgcgt cccgccccca tgtccgcggc gaggcggagc
    22141 gtggtcggcg acgcgtcggc gagcacgacg tcgacgccgc gcgcgcggag gccgagggcg
    22201 atgctcgtgc cgaggagtcc cgtgccgacg atgcggacgg tgccctgcac gcgcgtgtcg
    22261 gtcgcggcgg ccgcgcccgc ggcctcgctc actcgccgtc ctcgcggtcc acgtccccct
    22321 gcgcctcggc ggccgcgccg gcgccctgcg gcgtcgcggg tccggcctgc gcgcgggcct
    22381 cgcgcgagat ggtgaggagc tggccgagct cgtcggaggt gaggtcgcgc acgcggccga
    22441 cgcccaggga tccgaggtgc agcggcccga actggcgacg cacgagctcc tccaccgggt
    22501 ggccgacctc gtcgagcatg cggcgcacga tgcggttgcg gcccgagtgc agcgtgatct
    22561 ccacgagcgt ctggtcgccg ccgcccgaga ggatgcgcgc gcggtccgcc tggatcggcc
    22621 cgtcctcgag gtccacgccc tgcgtcaggc gctggatcgt ctgcagcgtg acgcggcccg
    22681 tgaccttcgc gatgtacgtc ttcagcacgc cgaaggacgg gtgcgcgagc acgtgcgcga
    22741 ggtcgccgtc gttggtgagg atcagcaggc cgctcgtctc cgcgtcgagg cggccgacgt
    22801 tgaagaggcg ctcctcgaac tcctccgtga actcgcggag gtcggggcgg ccgcgctcgt
    22861 cgcgcagcga ggagtagatg ccgaccggct tgttgagcat gaggtagcgc ttcgaggtgt
    22921 cgagctgcac ggcctggtcg tcgaccgcga cctcgtcgac gtcggggtcg atgcggcggc
    22981 cgggctcggt gacgacctcg ccgttcacgg tgacgcggcc cgcggcgatc atgtcctcgc
    23041 agacgcggcg gctggcgacg ccggcggcgg ccatcacctt ctgcaggcgg acgccctgca
    23101 ccggctcgtc cgggttccag gcatggtcag aggagggggt catggaagcc ttccgccccg
    23161 tc
//
