LOCUS       NZ_CP073683            22388 bp    DNA     circular CON 15-MAY-2024
DEFINITION  Paenibacillus sp. S25 chromosome, complete genome.
ACCESSION   NZ_CP073683
VERSION     NZ_CP073683.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus sp. S25
  ORGANISM  Paenibacillus sp. S25
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5958851)
  AUTHORS   Li,T., Mann,R., Kaur,J., Spangenberg,G. and Sawbridge,T.
  TITLE     Transcriptomics differentiate two novel bioactive strains of
            Paenibacillus sp. isolated from the perennial ryegrass seed
            microbiome
  JOURNAL   Sci Rep 11 (1), 15545 (2021)
   PUBMED   34330961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5958851)
  AUTHORS   Li,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2021) Agriculture Victoria Research, AgriBio, 5
            Ring Road, Bundoora, VIC 3083, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 31-MAR-2020
            Assembly Method                   :: Unicycler v. 0.4.8
            Assembly Name                     :: AVR_PaeniS25_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019454085.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 03:29:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,267
            CDSs (total)                      :: 5,136
            Genes (coding)                    :: 5,079
            CDSs (with protein)               :: 5,079
            Genes (RNA)                       :: 131
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 91
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 21 of 57
            Pseudo Genes (incomplete)         :: 38 of 57
            Pseudo Genes (internal stop)      :: 14 of 57
            Pseudo Genes (multiple problems)  :: 14 of 57
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:16:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4161694
            Orig. end                         :: 4184082
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073683.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from AgriBio, 5 Ring Road,
            Bundoora, Victoria 3083, Australia.
            Annotated using prokka 1.14.6 from
            https://github.com/tseemann/prokka.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22388
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="20"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..22388
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22388
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12388](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12388)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    583..599
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.4"
                     /tool="antismash"
     misc_feature    649..666
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            complement(780..1223)
                     /locus_tag="KAI37_RS18180"
                     /old_locus_tag="KAI37_03687"
     CDS             complement(780..1223)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS18180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KAI37_03687"
                     /product="hypothetical protein"
                     /protein_id="WP_220029948.1"
                     /transl_table=11
                     /translation="MIANSAMRNLLNNLTESNLSMSLDLFNPDFCMWNDCILLDASSLR
                     NIHSIEKTIYQDQMDLEASINHYHIENLKTGLELIENWEERLKLKYPKREFILILSSTI
                     TGEDVVIRFYQLRNYEPEWIKLKDLEGYREEAILVMEILNAIQ"
     gene            complement(1400..1624)
                     /locus_tag="KAI37_RS18185"
                     /old_locus_tag="KAI37_03688"
     CDS             complement(1400..1624)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689034.1"
                     /locus_tag="KAI37_RS18185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03688"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_220029949.1"
                     /transl_table=11
                     /translation="MNVIKCNIRELMAEHRIDDITELMVRSGLSRNSINKLYRETNIET
                     TKLETLFKLCDTFNCKLSDLIEYVPEEEN"
     gene            1779..2066
                     /locus_tag="KAI37_RS18190"
                     /old_locus_tag="KAI37_03689"
     CDS             1779..2066
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018883097.1"
                     /locus_tag="KAI37_RS18190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03689"
                     /product="hypothetical protein"
                     /protein_id="WP_220029950.1"
                     /transl_table=11
                     /translation="MVNTLESLTEPLIRIRLELLYTELLDCHAEYTRLSSETDQYFKTL
                     RDALPDQLQHTVFLYEDAQISLQSILERSIYIQGFKDALQLFSELQNSSI"
     gene            complement(2232..3620)
                     /locus_tag="KAI37_RS18195"
                     /old_locus_tag="KAI37_03691"
     CDS             complement(2232..3620)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS18195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KAI37_03691"
                     /product="hypothetical protein"
                     /protein_id="WP_220029951.1"
                     /transl_table=11
                     /translation="MEKIVFSQITYAYEFTNIEIFFKYKNMTFFSTDNLTSVYTDSGAS
                     QAREFQLNCITSIEMHEGINESNRYNRASILTILGIVSFFVGIPLTVYHKIKGEDTIIP
                     NNLINEEPLKLTIENEDYTEQLKSVLEKLESDEEVVVSLLDRWRKANYLVNESVDANLY
                     HDEAILNYFHIIELICEIYSKDLRIDLEENIKGYVEEFYKKHFFFNENQLESQVNSVKK
                     VFTEVLIGRDLALSHKIKFVLTKFNMLNPFVEYFIDSVIKTRNAIAHGRFTYQEKLSWP
                     LPPFLFMSNESFEILDSLNFLTARLISCYLGIECWKKEWEEVDKDLMPPDKLLEKFLTN
                     VSEYPELNCVSINEPNQYHITWRSIFKHYVSNPKKFKIEKIETVLKSFFMDCTVNESSA
                     SDLFNISVILSDSKDEEIQNTAIKNIDLIIQNRWYLWSNKRDIYSYLEKMNVPPIWYLS
                     YLKQ"
     gene            complement(3706..4920)
                     /locus_tag="KAI37_RS18200"
                     /old_locus_tag="KAI37_03692"
     CDS             complement(3706..4920)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025448.4"
                     /locus_tag="KAI37_RS18200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03692"
                     /product="Shedu immune nuclease family protein"
                     /protein_id="WP_220029952.1"
                     /transl_table=11
                     /translation="MIRFEEIEDEIIIRYTPRDGGYWIAKKFEDNKEIAIHKTFYFEKN
                     DLYKEIGSEEFTIIEEAQFSFAKLEGDYFRVKKTAIGIEKELLIHKSIKFQLNIFKTWN
                     NISIFKRVFDVIEGDLSIGPKESDLPIEEFKKILEIFPKSTELRKYSNARISHILKEYV
                     DMKRDFVSDYNSYMSKKSVANSARSSLSASFAEYEIMKYRIVLNRLKDMLKNEKGYSES
                     DWQNEIIDVLILIYPKYITVFKEVIVYDDYDSKERRLDYMLVDSNGNVDVVEIKKPNSN
                     ALISTRTYRDNYVPVRELSGTIMQVEKYLFHLNKSGRQGELKLTDKYKDLLPDGFKINI
                     TNPNAILILGREEDLGIEQLRDLEVIKRKYKNVMDIVTYDDLIRRLERIIEKFQSQIAE
                     NPFKK"
     gene            complement(5234..5752)
                     /locus_tag="KAI37_RS18205"
                     /old_locus_tag="KAI37_03693"
     CDS             complement(5234..5752)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS18205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KAI37_03693"
                     /product="hypothetical protein"
                     /protein_id="WP_220029953.1"
                     /transl_table=11
                     /translation="MEPFFKKPEEVDEYFNKVTDSLLILKARITALYKSDKDSIEYFAF
                     YESILTQVRALFIENSRYKNNYTVQVFLNKLGLSKTSEEIHTYLNSELIPSISIRDAIK
                     ISVDRFIVHYDQVSIEEKHIEEICREHLTDIKNEFFIGRLVDIISGHMLLSYVKRMNDW
                     EVDWFEGKQ"
     gene            complement(6350..6730)
                     /locus_tag="KAI37_RS18210"
                     /old_locus_tag="KAI37_03694"
     CDS             complement(6350..6730)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821733.1"
                     /locus_tag="KAI37_RS18210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03694"
                     /product="immunity 22 family protein"
                     /protein_id="WP_220029954.1"
                     /transl_table=11
                     /translation="MNYFEKNMVSVWYGHFASDDELFEYVEIKYPEDENEDVFSGFLND
                     HEIDDFDEDFAEGVFLMDGADDGIKDVSYVDSFLSPLLHDLSKIDGKYNSLFFIYDCNT
                     SGLSEKNGEKLRFLAAYPYSKD"
     gene            complement(6886..8949)
                     /locus_tag="KAI37_RS18215"
                     /old_locus_tag="KAI37_03695"
     CDS             complement(6886..8949)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372332.1"
                     /locus_tag="KAI37_RS18215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03695"
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_220029955.1"
                     /transl_table=11
                     /translation="MSQNIKKRVVRSSSIANTLAMVLLVIIVVVFATLGTFMFASTQSI
                     LVKQQEAMLQTKTQAVVTQFDALFKEKGSLVKQMSTNNLFKQYLETTPSAEMVKTSPYA
                     AETVATLAAIVKAEPSFADAWIAGISGKGFFLQNDGVASKPDFDIHTRPYFKPAVEADG
                     LYYSEPYKDVNSGNVLMGIFYPIKDSSNQLIGFAAVDIAFKDIPAVMQSYSLGSTGYSI
                     LASKTGDILYHPDQNKVLKEKINESTGDLGEIGKKMIAGESGVQLINDNGEPRYIGYAT
                     SKDTGWSVGLTISEDEVLTELKTFTWLTIGGFAAATILLVVICYITLRYLLRSIPKLLA
                     KIKLIENGDLTVQFDTQSNNEIGQISQGIYNMVQKIQGMLQMVGGSAQVLNQSSHDLQS
                     ISSRTAITMNDTATAINEIANATNYQSIETDNILQKTGALSGQIDEIANDAKAIETMVQ
                     ISAEQSGQGLAVVDQLSRWAEENHNSTQAMSSIIQEIDLSRHEISSIVDTVNQIATQTN
                     LLALNASIEAARAGEQGKGFAVVAGEVRKLAEQTALATQEIYKKVRVIEEKTSVSVEHT
                     VHGLKIAEENARSVEDTKQVFFSINKDLEDLKLRMIQISTNTSKVHKHKDEILQALEII
                     SSTTEENSASTEEVSASTQEQLESFEQVAELSKQLNQLSNKLQDELKQFKVE"
     gene            complement(9234..9773)
                     /locus_tag="KAI37_RS18220"
                     /old_locus_tag="KAI37_03696"
     CDS             complement(9234..9773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428282.1"
                     /locus_tag="KAI37_RS18220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03696"
                     /product="CueP family metal-binding protein"
                     /protein_id="WP_220029956.1"
                     /transl_table=11
                     /translation="MKKGILVASGLVVAALGTYLIAGNIQKEGVENHETTDIKQLVHDI
                     SAGKATAQSASINSSQLIVTGDDTQTVNYDLPDNEFFVSIAPYVEQTHPCATHSLTGCQ
                     GEIKNGAFNVTVHDSEGNVIMENAAMKSQSNGFIDLWLPRDKTYRISVNHEGKTAETEF
                     STYEKNDTCITTMQLG"
     gene            complement(10001..12388)
                     /locus_tag="KAI37_RS18225"
                     /old_locus_tag="KAI37_03697"
     CDS             complement(10001..12388)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431396.1"
                     /locus_tag="KAI37_RS18225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03697"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_220029957.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.3e-42, bitscore:
                     144.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHHMNEKLQANTGYQLAERKAIQYFALLYDQVLDKSYVTTLTEDI
                     QKWKKNHLQHSSWLSFFSRRKRKPDTWDYNRYIQWLNYTGKLDDYLDRSVSYIYMRDLG
                     KALDSPDTHTRIQRVIADVKKHLIQSTSANGGDQPEFMNLAGVYRWAQREGIETAIIWV
                     INKLRSVSSHIPKEMDAEQAQRKLIKIIIGVILHVMEEMDDTVLPVERARRLDEAIRLG
                     YSYGLTYPFIDDLLDSQVLTVQEKEQYSRMIRAALLSGSVPELGDWTGNHMELIQYIHS
                     ELSDAFEYIKEHQRPDTQQTFFEQSYVFFHAQDIDRVKDLTRATYTNEELYIPVILKSS
                     SSRLIVRSVISAPADEGFEQRTFFYGIYNQLADDFADMVDDMRDGAVTPYTYYLKYHHQ
                     RSDLINPFELYWAVISYLIHNVYDSDAMAREVILDRAMNGLKRYKERVGIEKYNETMGI
                     FASRNPEFNNLIQKMVQKADDVDFLDKLLRDQMITHLKNDAREKEDFFNTVKMVREQIN
                     NQLKITKPQGIPVMKERLIEAANYSLEGDGKRIRPILTWVMGVNEYGLDASAIVPLLRS
                     LEYMHTASLIFDDLPSQDNASTRRGRQTLHQVHNSATAELTGLFLIQKAIGEQSSLDQF
                     NAETVLALIQYSARKAEDMCMGQAMDLDSKGKALTLEQLNMVCFYKTGVAFEACLVMPA
                     MLAQVKESEIAALKKFAYHMGIAFQIKDDLLDVEGDMLLLGKPVGQDSDNNNSNFVSIL
                     GLEGASKEMWEHYCLAMEALEEIPRNIAFLKHLIHYVVNRDR"
     misc_feature    12398..12412
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.4"
                     /tool="antismash"
     gene            complement(12609..13529)
                     /locus_tag="KAI37_RS18230"
                     /old_locus_tag="KAI37_03698"
     CDS             complement(12609..13529)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688151.1"
                     /locus_tag="KAI37_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03698"
                     /product="hypothetical protein"
                     /protein_id="WP_071642055.1"
                     /transl_table=11
                     /translation="MSHPHKQLHSFVDISNDMKGFEIVSTQFGPDGRVYILLIDKVPER
                     VRGMFTPASLKDRHTYKVLILDDHIEEVCVEAQQFNYHYVQPLKNHLLLVGARCHYYGP
                     GQYDLNGKIIDYEGRTVNELLLGDGIQSVQVTEEGTIWTSYFDEGIFGNYGWNEPVGSS
                     GLVAWNKEGHKIYENQAADIHDCYALNVVSEQEIWFYYYSDFSLGCISGSDRTNITFMN
                     PRISGCSGVATDGYHFLFDGGYGKDGQYVLKKNVKPGSLSKGQNIRFLNDDQEFLQPHE
                     QDFRKNRLLLREGSLLYQVAVEELA"
     gene            complement(13691..14644)
                     /locus_tag="KAI37_RS18235"
                     /old_locus_tag="KAI37_03699"
     CDS             complement(13691..14644)
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013311293.1"
                     /locus_tag="KAI37_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03699"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_071644345.1"
                     /transl_table=11
                     /translation="MALIKDRFLGCLVGLAVGDALGTTVEFSSPGTFEPVTDIVGGGVF
                     GLKPGQWTDDTSMALCLAESMVRKDGFDPADQMRRYTNWYHLGYMSSTGTCFDIGGATR
                     AALHRFEATGDPYSGSVDPMTAGNGSIMRLAPVAMAYANRPEEAVMYAELSSRTTHGAV
                     ESVEACAVLASILVAGLRGADKESMLSVDVCYKWRQDEPAYSAAIEEIIQGSYKHKEPP
                     EIQGSGYVIRSLEAALWAFYHSASFEEGALLAVNLGDDADTTGAVYGQIAGAYYGLSGI
                     PSRWREKLAMKETIDELAEALWHKVEKDQTLQGEHL"
     gene            complement(14726..15814)
                     /locus_tag="KAI37_RS18240"
                     /old_locus_tag="KAI37_03700"
     CDS             complement(14726..15814)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016324602.1"
                     /locus_tag="KAI37_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03700"
                     /product="hypothetical protein"
                     /protein_id="WP_258382997.1"
                     /transl_table=11
                     /translation="MMPFHHVSLPDLPPSIGRLTAIHPLKGDSQESITLLALNTQAELW
                     RLELRSGSAELCTRICIPDFNPMQPVQMVTSSDGRYVAISNRFGRHAAVYDLVHAQEKM
                     QLSRDEYHYDKSMFPLAFVHQDGACILVHGTEWNRLDLTDVETGMLLTARPTPVYNSES
                     KNEHYLDYFHGRLLISPGGKWIADTGWGWAPLGVVRTWSLSDWLMNPWESENGPSVRHL
                     WQTIDWDGPVYWTGPDTLAVWGQMDADLLEEEDWGEEGVEPAVVLFDMTQTGYRRVLPA
                     IPSLNCKPLVDGTFPYPQADMAICGDQLFLWGKGVPLQVWRLSSGVREYVDTERFPLVY
                     HQEAGIFIELKADSRCKALSYE"
     gene            complement(15814..16806)
                     /locus_tag="KAI37_RS18245"
                     /old_locus_tag="KAI37_03701"
     CDS             complement(15814..16806)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013311297.1"
                     /locus_tag="KAI37_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03701"
                     /product="hypothetical protein"
                     /protein_id="WP_220029958.1"
                     /transl_table=11
                     /translation="MSFSKIYDYKLRAYFNERISDLSHEYLFYSYPDQEQNLRILTLNI
                     NEQDYVSLVRWHDLFDRSIFTKMDDIIRSERDTERLIRLLSFIFNVFDIHKDVAYRRKN
                     LFCFYYQYQVSHLRERGNEFSLTQDRLFFLHHLLFELGLGDDIYDRLTIENNRIMYRME
                     DAQYYDLHILINILHEHINKSRMDMDTQAALEKIKFLQGQWVNFMLGSHDVYDFPFDDF
                     NKPFVEATMFMQAYKSNKNGVLEVLIDCINEHQSPTEQFISHLILMNYSYFVLKSDPSE
                     ITYLKLFCKKKPGVFMKVLTALLEIRFFIDKSSFTNVGIDYYLSRIKGV"
     misc_feature    complement(16918..16931)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.61"
                     /tool="antismash"
     gene            17018..17668
                     /locus_tag="KAI37_RS18250"
                     /old_locus_tag="KAI37_03702"
     CDS             17018..17668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428289.1"
                     /locus_tag="KAI37_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03702"
                     /product="hypothetical protein"
                     /protein_id="WP_220029959.1"
                     /transl_table=11
                     /translation="MKQLSEALARFVQQQNLYNDAYGLFQNHDIQPRMENLTDCWDRRI
                     PVSPELEYLYSHYEMIDAKAAGTHKLKNAAVEIGDAAVLFFAAPEHLYRQQLGYRWITS
                     GEFVQESSSWPPHHVVIANFNDDPVIVDTSALGSPVYAAFEGGAAQQVADSLANFFTAL
                     SILIEGACTFKGELKDEDTYETKAEYIEHVKPLLHPLLSENQTTYLMEYLSLC"
     gene            17701..18270
                     /locus_tag="KAI37_RS18255"
                     /old_locus_tag="KAI37_03703"
     CDS             17701..18270
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428290.1"
                     /locus_tag="KAI37_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03703"
                     /product="DUF1697 domain-containing protein"
                     /protein_id="WP_220029960.1"
                     /transl_table=11
                     /translation="MIYIALLRGINVGGNNKIEMKKLKQTFENAGMGHVTTYINSGNII
                     FSSQTQSNQELSLILEQAILEDFSLPIRVIVRNMKEIQSIMEALPNEWSNDTQMKSDVM
                     FLWDEINDISVLDKLPLKPGIGHVIYTTGAVLYSVSKEQVTKSGLTKLVGTKLYQQMTV
                     RNVNTTRQIYKLMQTTEQEELQDTSS"
     gene            complement(18385..20130)
                     /locus_tag="KAI37_RS18260"
                     /old_locus_tag="KAI37_03704"
     CDS             complement(18385..20130)
                     /GO_process="GO:0006935 - chemotaxis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688156.1"
                     /locus_tag="KAI37_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_03704"
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_220029961.1"
                     /transl_table=11
                     /translation="MSNKLSDRTKKGKGFRDLKVTTTMISMIVISLVGLLIVSLVGVIG
                     MYQAKEGQGILYVDRFQHQTNILEVKSDFYNMRANYTKILDNKEYTDKQYKQVQKGKDS
                     VTTGLNEFSQRNLDAKEQKLYEELRGSIDTYYQDIEQIMAVKKNSGTYDTEERGRINKS
                     STAIVTMLTTISDYNNEQSANLYQNTQNEIKMRTIVLITVLALVLAILITISFAAIRNI
                     RFRMSTITKYCEEITQGNLTAALDPALLKGNNEIAVIARAIQQMTDSTSMVITGVINES
                     RQINQLSDQTNYNMTDLNERIRDVSATVEQLSAAMEETSAYTENMNHSAEEMQRAAEYI
                     SVKTQERAQSANDTSVKAETLKHAASESNKAAKEIYRKANEKMKEALERAKAVGQIRLL
                     SQSILEITAQTNLLALNASIEAARAGESGRGFAVVANEIRKLADGSKHAVDQIQSVTQE
                     VVQSVENLTTNAEELLHFLQAQVGKDYQLLEDTAGQYYNDAVEHTNTVNDLNATSKQVN
                     ATIQTMVRAIHEIATASEQSAISTQHIAENMVSSTEKSLEVAHQSDQVKESAARLNELV
                     EGFKI"
     misc_feature    complement(20462..20478)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
ORIGIN
        1 atacatataa gcattacttt ctccaactaa ttttatagat atggatctat gctctccatt
       61 tgaacttgca cttaatgtaa tggaaaaagg attcgcagta ccaccaaccc atgttgacca
      121 gttatatttt atagcttggt cgactaaagt agttactaga tcctcaaatt caagtgtttt
      181 aaatttcttc caatccactt ttctactttt tgtgaatttt ctccaattgt cttgagttat
      241 tgcttctgtt tcttctattc caaagataga tgctaataca ctaaaacctt gctcatagtt
      301 atttctgaaa tctgcaaatc ttcgatctgc taaaaaataa ggtatgttac attctctata
      361 aaatatgggt agaacaaata ctttttttga ctgcatttgt tttacccatg ccgctccaag
      421 ttcactctta acccattcag aattcagtgc ttcgggagaa agtacaattc ctaaatattc
      481 attctctctt atcccttcct ctattttcca agtaattgaa tcacctattt taatctccca
      541 tttatcgaac catacattta caccaattct ctttaaatct cttgctaatt tttctacaaa
      601 tggtttgtct aaactggtat gacttaaaaa aatactaggc atctctttca tcccttcatg
      661 cgaatatttc ggctaacgtt cctgtattca cgacccgacg tatgtcgggt gttcggcgaa
      721 tgccgaacca agggcgtatg cccgcagcgt gaatattatg ttataggaag cacttcacat
      781 cattggatcg cattcaaaat ctccataact aaaatagctt cttctctata cccttcaagg
      841 tctttcaatt taatccattc aggctcgtaa tttctaagtt ggtagaatcg aatcaccaca
      901 tcttcgcctg taattgtaga acttaaaatc aaaataaatt ctcgtttagg atatttcaat
      961 tttaaacgct cttcccaatt ttcgataagt tctaatcctg tctttaagtt ttcgatgtga
     1021 taatgattaa ttgatgcttc tagatccatt tgatcttgat aaatggtttt ttcaatagaa
     1081 tgtatatttc ttaaacttga agcatctagc aaaatacaat cattccacat acaaaaatca
     1141 ggattgaata ggtctaagct cattgatagg ttagactcag ttaagttatt taataaattt
     1201 ctcatcgcac tgttggctat catgtttttc ctgctttcga agtgtttcgt ataacattcc
     1261 tgtattcaag acgtccgacg aagtcggatg tgtctgctga aacgcttcca caaaattcat
     1321 ccagcagacc aaggctccaa aggagccgca gcttgaatat tatgttatac gacggaatca
     1381 cttcttgaat ataccttcac taattttctt cttcaggtac atactcaatt aaatccgata
     1441 atttgcagtt aaatgtatcg catagtttaa ataaagtttc tagctttgtt gtttctatat
     1501 tcgtctcccg atataacttg ttgattgagt tacgacttaa gcctgatctc accatcaatt
     1561 ctgttatatc atctattcga tgttctgcca tgagttctcg tatattgcac ttgattacgt
     1621 tcatcttttc ccctccatag ttttatctta tcttccacag tagtaatcat caattaaaag
     1681 cgaagtttta actctacaaa ggcaaatatt caccttgtaa ttaactttgt aaggttatat
     1741 aataactcta tagagttaat cgaaggagga aacaggatat ggttaataca ttagaatcgc
     1801 taacagaacc actgataaga atacgtctag aattactcta tactgagctt ttggattgtc
     1861 atgcagaata cactcggctt tcttctgaga cagatcaata ctttaaaaca cttcgtgatg
     1921 ctttgcccga tcaacttcaa catacggttt ttctttacga agacgctcaa atttctcttc
     1981 agtccatctt agaaagaagt atctacatac aaggtttcaa agacgctcta caactcttta
     2041 gtgaattgca aaactctagc atttagagga tcatatgatc ctcttttcta ttgtatttta
     2101 ttctgtcgta aaacgtttct gtattcgtga acctcgaagg agctttctac tgaaatctct
     2161 ctccgaagtt cactcagaag accaaggctt tgtcaggaga cgccgcttaa atattatgtt
     2221 agataagatc tttactgctt taaataactc agataccaga taggtggaac attcattttt
     2281 tctaaataac tataaatatc tcttttatta gaccaaagat accacctatt ctgaattatc
     2341 aaatctatgt tctttatagc tgtattttga atttcctcat cctttgagtc acttaagatt
     2401 acagatatgt taaataaatc actggcgctg gactcgttga ctgtacaatc cataaagaag
     2461 ctttttaata cagtttcaat tttttctatt ttgaattttt taggattact tacataatgt
     2521 ttgaaaattg acctccatgt aatatgatac tgatttggtt cattaatact tacacaattc
     2581 aactcgggat attccgaaac atttgtcaaa aatttttcta gcaatttatc agggggcatt
     2641 aaatctttat ctacttcttc ccattccttt ttccaacatt caatccctaa ataacagcta
     2701 atcaatctag ctgtaagaaa gtttaaggag tctaatattt caaacgattc attagacatg
     2761 aacaaaaacg gtggtaaagg ccaagataat ttttcttggt atgtaaatct cccatgagca
     2821 atagcattcc ttgtttttat tacagagtct ataaaatatt caacaaaagg attcaacata
     2881 ttgaatttag ttagaacaaa tttaatttta tgtgacaatg ctaagtccct accaatcaaa
     2941 acttcagtaa agactttttt tactgaattg acttgtgact caagttgatt ctcattgaaa
     3001 aagaaatgtt ttttataaaa ttcttcaaca taccctttta tattttcttc caaatctatt
     3061 cgtaaatctt ttgagtagat ttcacaaatt agttctataa tatgaaaata attaagaata
     3121 gcttcatcat ggtagagatt tgcatcgacg ctttcattta ctaagtagtt tgcttttctc
     3181 caacggtcta ataaagatac tacaacctct tcatcggatt ctaacttctc caacacagat
     3241 tttaattgtt ccgtataatc ttcattttca atagttaatt ttaaaggttc ctcattaatt
     3301 aaattattcg gtattattgt atcttctcct tttattttat gataaaccgt taatgggatt
     3361 cccacgaaaa aagaaacaat tccaagtatt gtaagtatac ttgctctatt gtatctgtta
     3421 ctttcattta ttccttcgtg catttcaata ctggtaatgc aattcaattg gaactccctt
     3481 gcttgagaag ctccactatc tgtataaacg cttgtaagat tatcagtact aaaaaaagtc
     3541 atatttttat atttgaagaa gatctctata tttgtaaatt cataagcata tgtaatctga
     3601 ctgaaaacta ttttttccat ctgtattctc ctttatgtca tctaacgttc ctttattaac
     3661 gactcagcat tcgctgagtc gttaatatta tgttatacga cggaatcact tcttgaatgg
     3721 gttttcggca atttgacttt gaaatttttc aataattctt tctaatcttc taataagatc
     3781 atcatatgta acaatgtcca tcacattttt atactttcgt ttaataactt ctaaatctcg
     3841 aagttgttca atcccaagat cttcttctct tccaagaatt aatatagcat taggatttgt
     3901 tatgttaatc ttgaaaccat ccggaagcaa atccttatat ttatctgtta gcttcaattc
     3961 accttgtcta cccgacttgt ttaaatgaaa cagatacttt tctacttgca tgatagtacc
     4021 cgagagttct ctaacaggga cataattgtc tctatatgtt cttgtcgaaa ttaaagcatt
     4081 agaattaggt ttttttattt caaccacatc aacatttcca tttgagtcaa ctagcatata
     4141 atctaatctt ctttctttcg aatcgtaatc gtcgtagacg attacttctt tgaatactgt
     4201 gatatattta ggataaatca atattaaaac atcaataatt tcgttttgcc agtctgattc
     4261 agaatagcct ttttcatttt tcagcatatc tttaagacga ttcagcacta tccgatactt
     4321 cattatttca tattcagcaa atgaagcact taagctagac ctagcactat tagcaactga
     4381 ctttttagac atgtaggaat tatagtccga tacaaaatct cgtttcatat ctacatattc
     4441 ctttaatata tggctaatcc ttgcattcga atatttccgt agttcagtgg atttggggaa
     4501 tatctctaat attttcttga attcttctat aggtaaatcc gactcttttg gtccaattga
     4561 caaatcccct tctatcacat caaaaaccct tttgaaaata gatatattat tccatgtctt
     4621 aaatatattt agttggaatt ttatactttt atggatcaat aactccttct ctatcccaat
     4681 tgcagttttc ttgactctaa aatagtcgcc ttctaacttt gcaaaagaaa attgtgcctc
     4741 ttctattata gtaaattctt ctgaaccgat ctccttatat aaatcattct tttcgaagta
     4801 aaaggtttta tgtatagcta tctccttgtt atcttcaaat ttcttcgcta tccaatatcc
     4861 cccatccctt ggtgtgtatc gaattataat ttcatcctcg atttcttcga atctaatcat
     4921 aaaatctcct taataaacat tttttacctt aagattaaat tagttctcta tatttagcgc
     4981 atagtttata tttaatggat tcttaaacac gattacatct gtgtgttata tatctgctat
     5041 ttagattctg tcgtataacg ttcctgtatt tacgacgcct ggcgaatgcc aggtgtgtcc
     5101 agctgcctct gcttccccga aatccctctg ccggaccgag ggcgtatgcc cgatgcgtga
     5161 atattatgtt atacgtagtt actgtcttct tcgagttttc tcacaaaaat cttcctctag
     5221 aaagttagtt catctattgt ttaccttcaa accaatcaac ttcccaatca ttcatacgct
     5281 tcacatatga aaggagcata tgacctgaaa taatatctac taatctgcct ataaaaaatt
     5341 cattcttaat atcagttaaa tgctctctac aaatttcttc gatatgtttt tcttcaatag
     5401 aaacttgatc ataatgaaca ataaatctgt cgacacttat cttgatagca tctctaatac
     5461 taatgctagg tataagttcg ctatttaagt atgtatgaat ttcctctgag gtctttgata
     5521 accccaattt gttcaaaaaa acttgaacag tataattgtt tttatatcga ctgttttcaa
     5581 taaataaagc tctaacttga gtaagtattg actcgtaaaa agcaaaatac tctatagagt
     5641 ctttatcaga tttatataat gctgttattc ttgcttttaa gattaataga ctatcagtca
     5701 ctttattgaa atattcatca acttcttcag gctttttaaa gaagggttcc atcttaaaat
     5761 ctcctcgctt ctatttacag taattacgta taacgtcata ttcacgaact tcgtgaatcc
     5821 tgcactttgt tcctgattcc cgcactttct gcgtttcaat cctcctgccc gctcatccga
     5881 tccaacggac tttgaatccg cccaatgtcc cgcctgctca catgtgtata ccgctccgtc
     5941 gttcgcacac tctgatgccc cagcagttcc tgaaaatagc gaagatcaat ctaagcttaa
     6001 cgttccgtca ggtggcggcc ttttctctgc tctggaaata gccagtcttc cggctgctcc
     6061 acctctttgt actgctcgac catcacaaaa gccgcttctg agagcagcgc ttgccgatcc
     6121 ttcctgcttc atccgataaa ataggtaatc ttcatgctcg cttgtctcct tagtatatca
     6181 gccgttcaaa aatttggaaa tctaattttg cacaaaaaaa gggccttaag atggaaattc
     6241 accttaaggc cctgattctt tcggatcaaa ttattgatcc tttaagttca attttcatta
     6301 tcataattac ttgtaatgag actccgaaga caaaagaata gtgtaaccgt taatcttttg
     6361 aataaggata tgcggctaaa aagcgtagtt tctcgccatt tttttcagat aaaccacttg
     6421 tattacaatc atatataaag aacaacgaat tatatttacc atctattttg ctcaaatcat
     6481 gtaatagtgg agataaaaaa gaatcaacat aggaaacatc ttttatacca tcatctgccc
     6541 catccatcag aaagactcct tcagcaaaat cttcgtcaaa atcatctatt tcatggtcat
     6601 ttaaaaaacc gctaaaaaca tcctcattct catcttccgg gtatttgatc tcaacatatt
     6661 caaacaactc atcatcagag gcaaagtggc cgtaccagac ggacaccata tttttttcaa
     6721 agtaattcat atcttcaccc cgctaatatt tcagtttata gtatggtcta tctatatcac
     6781 gcaccagcta tcatgccctt taccctacaa cagctgttga agctaaaaag cccgcgctgg
     6841 atgcgggctt tgctgtatat ttagtcaaaa tcatgcctag acttgttact cgaccttgaa
     6901 ctgttttaat tcgtcttgaa gcttattgga caattggttt aattgtttgg atagctcagc
     6961 aacctgttcg aagctctcca attgttcctg cgtgctggcg ctaacctctt cggttgaagc
     7021 ggaattctct tcggtggtgg aagatatgat ctccagcgcc tgcaaaatct catctttgtg
     7081 cttgtggact ttggaggtgt tggtgctgat ctggatcatt cgcaatttca aatcttccaa
     7141 atccttgtta atgctaaaga atacttgctt cgtgtcctcc accgatctgg cattttcttc
     7201 tgcaattttc agaccatgaa ctgtatgctc aaccgatacg ctggtttttt cttcaatcac
     7261 acgtaccttc ttgtagattt cctgtgtcgc cagtgcagtc tgctcagcca gcttgcgaac
     7321 ctccccggca accacagcaa accctttacc ctgttctcct gcacgtgcag cttcaatgga
     7381 agcattgagc gccagcaggt tggtctgcgt tgcaatttgg ttaaccgtat ccacgatgct
     7441 ggaaatctca tgacggctca gatcaatctc ctgaataata gacgacatcg cttgtgtgga
     7501 attgtgattt tcttccgccc atctggataa ctgatctact accgcaagcc cctgtccgct
     7561 ttgctcagca gagatttgca ccatcgtttc gatggctttg gcatcattgg caatttcgtc
     7621 aatttggccg gataatgctc cggttttttg taaaatgtta tccgtttcaa tagattggta
     7681 gttcgttgca ttggcaattt cattaattgc tgtcgcagta tcgttcatcg taatcgccgt
     7741 tctggaagaa atggattgca aatcatgaga agactgattc aacacttgag ctgagccacc
     7801 caccatttgg agcatgcctt gaattttttg aaccatattg taaattcctt gagaaatttg
     7861 cccgatttca ttgttggatt gcgtatcaaa ctgaacggtc aaatctccat tttcaatcag
     7921 cttgattttt gcaagcaatt tcgggattga tctcaacaga taacggagcg ttatataaca
     7981 aatcacaacg agcaggatgg tggctgccgc aaaaccgcca atggtaagcc aggtaaaggt
     8041 ttttaattct gtgagcacct catcttcaga aatggttaag cctacagacc accccgtatc
     8101 tttactggtt gcatacccaa tataacgagg ttccccatta tcattaatta gctgtactcc
     8161 ggactcacca gcaatcattt tctttccaat ctccccaagg tcacctgtgc tttcgttaat
     8221 cttttctttc agcactttat tttgatcggg gtgatacaaa atatcacctg ttttggacgc
     8281 aagaatcgaa taacctgtgc ttccaagcga atagctttgc ataacggcag ggatgtcttt
     8341 gaaagcaata tcaactgcag caaatccgat taattggtta ctgctatctt taatcggata
     8401 gaaaatgccc atgagcacat tacccgaatt gacgtcctta tagggttctg agtagtataa
     8461 accgtctgct tcaacagctg gcttgaagta tgggcgtgta tgaatatcaa aatccggttt
     8521 agaagcaaca ccatcattct gaagaaagaa gcctttacca gatattcctg caatccaggc
     8581 gtcggcaaaa gatggctctg cctttacaat ggctgccaga gtcgctactg tttccgcagc
     8641 ataaggagaa gttttcacca tttctgccga tggggtggtt tctaaatatt gcttaaaaag
     8701 attattcgtt gacatttgtt tgacaagtga tcccttttcc ttaaacaacg catcgaattg
     8761 agtgacaacg gcctgcgtct tggtctggag catggcctct tgctgcttga caagtatgct
     8821 ttgcgtgctt gcaaacatga acgtccccaa ggttgcaaag acgacaacga taatgactaa
     8881 caagaccatg gccaatgtgt tggcgatgct ggatgatcta actacgcgct tcttaatatt
     8941 ttgtgacatg ctgccatctc cccgaggaat attgagcgaa aagctcttag ataatatgtc
     9001 ggaagtttgc agttgtttta ataggttttt agtatacaca atttaaagtt tcgctatctg
     9061 attcctcata gattccctcc caacctgttc ggtaactcca gcaaaagatt agggcagcac
     9121 aaagagcctc cgtcagacgt aggctcttta ctaaaagcta tatatgagaa cgcagagttt
     9181 tgcggattta gagcgtttca gcgatccgta agctcaaccc tcatcctccg tcgttaaccc
     9241 aactgcatcg ttgtgataca cgtatcgttt ttctcatatg tagagaattc agtttcagcc
     9301 gttttacctt catgattcac gctaatacgg tatgttttat ccctcggtag ccatagatca
     9361 ataaaaccat tggattgtga tttcatggcg gcattctcca tgatgacatt cccttcggag
     9421 tcgtgaacgg tcacattgaa cgctccgttt tttatttcgc cttggcagcc tgttagacta
     9481 tgagttgcac aagggtgggt ctgttccaca tatggtgcaa tcgaaacaaa aaactcgttg
     9541 tcaggcaaat cataattcac ggtctgagta tcgtcccctg tcacaatcaa ctgactggaa
     9601 ttaatggaag cagactgggc tgttgccttg cctgcactga tatcatgcac caattgcttg
     9661 atgtctgtcg tctcgtggtt ttccacccct tctttctgaa tatttcctgc aattaggtat
     9721 gtccccaatg cggcaacaac caaccctgaa gcgactaaga ttcctttttt catttggagt
     9781 tcatctcctc gtctgttttg tattattata agggagaatg caccataatg ggaaaaatgg
     9841 ggtgctgaag tcaccagata ttcacatatc tgtgctgtga ttcagtcata tttgtataac
     9901 atagaggatt accgatgagc gaaggagcat gagcagctct tctgtctcaa cgtaaaaaca
     9961 ccccattact cttgtggagc aatggggtac actcgttttt ttaacggtcc ctgttcacga
    10021 cataatgtat taagtgcttc agaaaagcaa tattacgtgg aatttcttcc aatgcttcca
    10081 tcgcgaggca atagtgttcc cacatctctt tactagcacc ttcaagacca aggatggaca
    10141 cgaaattcga attgttatta tcagaatctt ggccaacagg ttttccgagt aagagcatat
    10201 ctccttccac atcaagcaaa tcatctttaa tctgaaaagc aatccccata tgataggcaa
    10261 atttcttcaa agcagcaatt tccgactcct tgacctgtgc aagcatggct ggcataacca
    10321 gacaagcctc aaacgccact cctgttttgt aaaagcacac catattcagc tgctccaagg
    10381 tcagtgcctt tcctttggaa tccagatcca tcgcctgacc catacacata tcctctgcct
    10441 tacgggccga gtattgtatc aaagcaagca ccgtttcagc attgaactgg tcaagtgacg
    10501 attgttcccc aatcgccttc tggatcagaa acagaccggt taattctgcg gtagcgctat
    10561 tgtgcacctg atgcaaggtc tgacgccctc tacgggtaga cgcattatcc tgggaaggaa
    10621 gatcatcaaa gatcagggag gctgtatgca tatactccag tgatctcaga agcggcacga
    10681 ttgccgatgc atctaatcca tattcgttca cgcccatgac ccaagtcaat ataggccgta
    10741 tccgcttccc gtccccttcg agactgtaat ttgcagcctc aataagccgt tctttcatga
    10801 ccggaatccc ttgaggcttg gtaattttca attggttgtt aatctgctca cgaaccattt
    10861 tgaccgtatt aaaaaagtct tccttttccc tcgcatcgtt tttcagatgg gtaatcatct
    10921 ggtcccgaag cagcttatct aagaaatcta catcatccgc tttttgtacc atcttctgaa
    10981 taagattatt aaattccgga tttctggatg caaagatccc catcgtttca ttatactttt
    11041 caatacctac acgttcttta taacgtttga gtccattcat tgcacgatcc agtatcacct
    11101 cacgagccat ggcatcggag tcatatacgt tatggatcaa ataggaaata accgcccagt
    11161 ataattcaaa gggattgata agatccgatc tctgatgatg atattttaaa tagtaggtat
    11221 agggtgttac cgcaccgtct ctcatatcgt caaccatatc cgcaaaatca tcagcaagct
    11281 ggttatagat accataaaag aatgttcgtt gctcaaaacc ctcatccgca ggagcactaa
    11341 tcacggaacg gacaatcaat cgggacgaag aagacttcaa aatcacgggt atataaagct
    11401 cttcattggt ataagtagct cgcgttaggt ccttaacacg gtcaatatct tgagcatgaa
    11461 aaaagacata ggactgctcg aaaaaggttt gctgtgtgtc tggccgctga tgttccttaa
    11521 tatactcaaa tgcatccgag agctccgaat gtatgtattg aatcaactcc atatgatttc
    11581 cggtccaatc gcccaactca ggcacagatc cactaagaag cgcggcacgt atcatacggg
    11641 aatattgttc tttctcttga acggtcaaaa cctgggaatc gagaagatca tcaatgaaag
    11701 gataggttag accataggag tacccaagcc tgatggcttc atcaagtctg cgagcacgtt
    11761 ccacaggcaa cactgtatcg tccatttctt ccatcacatg cagaataacc ccgataatga
    11821 tcttaatcag tttgcgctgg gcttgctcgg catccatctc cttgggaata tgggaggata
    11881 cggacctaag tttgttgatc acccaaatta tcgcggtttc tataccttcc ctctgggccc
    11941 accgatacac cccggccaaa ttcataaatt ccggttggtc tcccccgttt gcactggtgg
    12001 attggatcaa gtgttttttt acgtctgcaa tgacacgctg aatccgggta tgtgtgtcag
    12061 gagaatccag agctttgcct aggtccctca tataaatata ggagacactt cggtccagat
    12121 aatcatccaa tttgcctgta taattcagcc attgaatgta tctattatag tcccaagtat
    12181 caggttttct ctttctccgt gaaaaaaagg ataaccatga ggaatgttga agatgatttt
    12241 ttttccactt ttgaatgtct tctgtcaggg tagtcacata agatttgtct aagacctgat
    12301 catacaataa tgcaaaatac tggatcgcct tccgctcagc cagctgatat cctgtattgg
    12361 cttgtaattt ttcattcata tggtgcatta cctcaacttc tcattttgtt aaacatggtt
    12421 gtatttctcc ctgagggaac gaacttggat catgttttta tctttatacg gaaaaaaaac
    12481 tgtaaggtta cgaaattatc atgctgctta tcgatacccc ctctttggca atatccatga
    12541 atttaaaaca agaatatagg ctcaaattac tttcaatcaa caaaaaagcc cacgtctgac
    12601 gtgggttttt acgctaactc ttcaacagcc acctggtaca gcagagaacc ttcacggagc
    12661 agcaggcggt tttttctaaa atcctgttcg tgcggctgaa gaaactcttg atcgtcattt
    12721 aaaaaacgga tgttttgccc tttgctcaaa ctacctggct tcacattctt tttcaggaca
    12781 tattgtccat cctttccata tccgccgtcg aataaaaagt gatatccatc tgtagccacc
    12841 ccggagcagc cggaaatcct cggattcata aacgtaatat tcgtacggtc gctaccggaa
    12901 atgcacccta atgaaaagtc tgaatagtaa taaaaccaga tttcctgttc gctaaccacg
    12961 ttcaaagcat agcaatcatg aatgtctgcc gcttggttct catatatttt gtgtccctct
    13021 ttattccagg cgacaaggcc ggaggacccc acaggctcat tccaaccata attcccgaat
    13081 ataccttcgt caaaataact ggtccagatc gtaccttctt ctgtaacctg aacactctgg
    13141 ataccgtctc caagcagtag ttcattcacg gtacgacctt cataatcaat aattttacca
    13201 tttagatcgt attgaccagg tccgtaataa tggcaccgtg ctccgacgag taacaaatga
    13261 ttttttagag gctgtacata atgatagttg aactgctgcg cctccacaca cacttcttcg
    13321 atgtgatcgt ctaggatgag taccttgtaa gtatgtctgt ctttcaatga ggcaggcgtg
    13381 aacattcccc gcactcgttc tgggacttta tcaatcagca aaatatacac gcgcccatca
    13441 gggccaaatt gggtcgaaac gatctcaaat cctttcatat cgttggaaat atcaacaaat
    13501 gaatgaagct gtttatgtgg atgtgacaag gtaattcctc ctctgaaagg tcaataaaat
    13561 gaagtgttat ttgtattgaa ctcattttgt cataacggca tgttgctgag tagggcggaa
    13621 gtatggcgat atagcaaaca aaaaaacaag ctgggttctg cttcataaga aaagcagccc
    13681 agcttgacct ttatagatgt tccccttgga gcgtttggtc cttctcgacc ttatgccata
    13741 aagcctcagc cagttcatcg atcgtctcct tcatcgccag cttctcgcgc caacgactcg
    13801 ggataccgct tagcccgtaa taagcccctg caatctggcc gtacactgcc ccggtcgtat
    13861 ctgcgtcatc ccccagattt accgccagca gtgccccctc ttcaaatgaa gccgaatggt
    13921 aaaatgccca tagcgcagcc tcaagggaac gaataacata accgcttcct tggatttcag
    13981 gcggctcctt atgcttgtaa gatccctgaa tgatttcttc aatggctgcc gaataagcgg
    14041 gctcgtcctg ccgccactta taacagacat ccaccgataa catggattct ttgtccgctc
    14101 cccgcaaacc tgccacaagg attgaagcaa gcacggcaca ggcctccaca ctttcgactg
    14161 ctccatgggt ggttcgcgag ctcagctcgg cgtacatcac ggcctcttct ggacggttcg
    14221 cataagccat ggcaacaggt gcaagcctca tgatcgagcc attaccagca gtcatggggt
    14281 caacggaccc actgtacgga tctccggtag cttcgaagcg atgcagtgct gctctcgttg
    14341 caccaccaat atcaaagcac gttcctgtgc tgctcatata tcccaagtgg taccaattgg
    14401 tgtatcggcg catttgatct gccggatcaa agccatcttt tcgcaccata ctctcggcca
    14461 agcagagcgc catcgacgta tcgtccgtcc actggcccgg ctttaaccca aagacaccgc
    14521 cgcccacgat atccgttaca ggttcaaatg tacctggact gctgaattcc acagtggttc
    14581 ccaaagcatc acccactgcc agcccaacca ggcatcccaa aaaacgatcc ttgataagtg
    14641 ccattttggt tttacgcccc ttttcaaatg taataactaa tgcatatttt cccatctcgc
    14701 caggaaggaa gcccgacact gccatttatt cgtagcttaa ggctttacaa cggctatccg
    14761 ctttcaattc aataaaaatt cctgcctctt gatggtaaac gagtggaaac cgctccgtat
    14821 ctacatattc ccgcacaccg cttgaaagcc gccatacctg aagcgggact ccttttcccc
    14881 ataagaataa ttggtcaccg caaatggcca tatccgcttg ggggtaagga aaagtcccgt
    14941 ctacaagtgg cttacaattt agggagggga tcgctggaag cacacgccgg tacccggtct
    15001 gggtcatatc gaataggaca acagccggtt caactccttc ctctccccaa tcttcctcct
    15061 ccagcaaatc ggcatccatc tgtccccaaa ccgccaatgt gtcgggtcct gtccagtaca
    15121 ccggcccatc ccaatctatg gtttgccaaa gatggcgaac tgacggacca ttctccgatt
    15181 cccatgggtt catcagccaa tcggataagg accaagttcg gaccactcct aatggagccc
    15241 atccccatcc cgtatccgca atccactttc cccctggtga aatcagcagc ctcccatgaa
    15301 aataatctag atagtgctca tttttgcttt cgctgttata aacaggagta ggtcttgctg
    15361 tcaaaagcat gcctgtttct acatccgtca gatcaagccg gttccattcc gtcccatgga
    15421 caagaatgca tgcaccgtct tggtgtacaa atgccagggg aaacatactt ttatcgtagt
    15481 gatattcgtc ccgcgatagt tgcatttttt cttgagcatg gactaaatca tacactgccg
    15541 catgccgtcc aaaacgattg gagatagcta cgtatctgcc gtcagaactg gtaaccattt
    15601 ggacaggttg catgggatta aaatcaggaa tacaaatacg tgtgcacaat tctgcgctgc
    15661 ctgagcgaag ttctagtctc cacagttctg cttgtgtgtt tagtgccagc agggttatgc
    15721 tttcctgaga gtcgcccttt agtggatgaa tggctgtaag gcgtccgata gacggtggta
    15781 aatcaggtaa agaaacgtga tggaatggca tcattaaacc ccttttattc ttgataaata
    15841 ataatctata cccacatttg tgaagctgga tttatcgata aaaaatctga tttcaagcaa
    15901 tgcagtcaat actttcataa aaactcccgg ttttttcttg caaaacaact taagatatgt
    15961 aatttcgcta ggatcacttt tgagaacaaa ataggaataa ttcatcaaga tcaaatggga
    16021 gatgaactgc tctgttggag attgatgctc attgatacag tctatcagca cctctaatac
    16081 cccattttta ttagatttgt aggcttgcat aaacatcgtt gcttctacaa acggcttgtt
    16141 gaaatcatcg aatggaaaat catatacatc atgactaccc agcataaagt tgacccattg
    16201 gccttgtaaa aattttattt tttccagtgc tgcttgtgta tccatatcca tcctactttt
    16261 gttaatatgc tcatgcaaaa tgttaataag aatgtgcaga tcataatatt gtgcgtcttc
    16321 cattctgtac ataatcctat tattttcaat cgttagacga tcataaatgt cgtcacctaa
    16381 acccagttca aataagagat ggtgaaggaa aaatagtctg tcctgagtaa gcgagaattc
    16441 atttcctctc tctcttagat gtgaaacttg atattgataa taaaaacaaa ataagttttt
    16501 tctcctataa gcaacatctt tatgtatatc aaaaacatta aaaatgaacg aaagcaatcg
    16561 aattaggcgt tcagtatccc gttcgcttcg aatgatatca tccatttttg taaatatcga
    16621 cctgtcaaac agatcatgcc atcgcactag agaaacataa tcctgttcgt ttatattcag
    16681 ggttaatatt cttaaatttt gctcttgatc gggataagaa taaaatagat attcatgact
    16741 taaatcagaa atacgctcat taaaataagc tcttaatttg taatcgtata ttttagaaaa
    16801 tgacatgctt atcctcctta caagtaagcc tgagcatact aaactaagta caaaacattt
    16861 tcgaactcct atattgtaaa attaatctgg atagactggc aaggcggcac aattacagaa
    16921 acatatgttc tccatgtcta tattatgata tctttacgat agaagtaaac cgtgatgtca
    16981 aaggtcatag cctacaatta gaaaggaatg aacacctatg aaacagttaa gcgaagcttt
    17041 ggcccgtttt gtacaacagc aaaacttata taatgatgcc tacgggctgt tccaaaacca
    17101 cgacatccag ccccggatgg agaacctaac agattgctgg gacagacgga ttcccgtatc
    17161 ccctgagctt gagtacctgt atagccatta tgaaatgatc gatgctaagg cagcgggaac
    17221 acacaaatta aaaaatgcag cagttgaaat cggggatgcc gcggttctct tttttgccgc
    17281 accagaacat ctgtatcgcc aacaactagg ctatcgctgg attacatctg gtgagtttgt
    17341 ccaagaatct tcttcgtggc cgccccatca tgtcgtgatt gccaatttta atgacgatcc
    17401 agtcattgtc gatactagcg ctctcggttc ccctgtatat gctgcttttg aaggtggggc
    17461 agcgcagcag gttgccgact ctttagctaa cttctttacg gctctttcca tcctgatcga
    17521 aggtgcctgt acctttaagg gagaattgaa agatgaggac acctacgaaa ccaaagcaga
    17581 atatatcgag cacgtaaaac cattgctgca tccgctgttg agcgaaaatc aaaccacgta
    17641 tttaatggaa tacctatccc tttgttagaa atcctttttt tgaagagagg tgaagcttat
    17701 atgatctata tcgcattact gcggggcatc aatgttggcg gcaacaacaa gatcgagatg
    17761 aagaagctca agcaaacgtt tgaaaatgca ggtatggggc atgtgacgac ttacattaat
    17821 tctggaaaca ttattttttc tagtcagacc cagtctaacc aggagctttc actcatattg
    17881 gaacaggcga ttctggagga ttttagctta cccatccgtg tcatcgttcg taatatgaaa
    17941 gagattcaga gcattatgga ggcactgccg aatgaatggt ctaatgatac acagatgaaa
    18001 agtgatgtaa tgtttctgtg ggatgaaatt aacgatattt ccgttctgga taagcttcct
    18061 ttgaaaccgg gaataggcca tgtaatatat acgaccgggg ccgttctgta ttctgtcagc
    18121 aaagaacaag tcacaaaaag cgggttaacg aaattagtcg gcaccaagct gtatcagcaa
    18181 atgacggtac ggaatgtgaa cacaacacgg cagatctata agctgatgca aacgactgaa
    18241 caggaggagt tgcaggacac gagttcctga ctgtagtcca aaatcaatct tggaagagta
    18301 aacttaaaaa aggagccttt ttagggctcc tcaactgttt ttcttcgatg taatgttttc
    18361 cctagtcttt gtgtattgcc ctcgttaaat tttaaaacct tcgaccagtt cattcagtcg
    18421 ggccgcgctt tccttcacct gatcagactg gtgtgccact tcaagagatt tctccgtcga
    18481 tgaaaccata ttctctgcaa tgtgctgagt ggatatagcg gactgttcgc tggctgttgc
    18541 aatctcatga atcgctctaa ccatggtttg gatggttgca ttcacctgct tagaggtggc
    18601 gttcaaatca ttgaccgtgt ttgtgtgctc cacggcatca ttgtaatatt gtcctgctgt
    18661 gtcctcaagc agctgataat ccttgcccac ctgggcttgc aggaagtgta gtaattcttc
    18721 ggcattagta gttaaattct ctacagattg cacaacttct tgagtaacac tctgaatttg
    18781 gtctaccgcg tgtttggagc cgtctgccaa cttgcgaatc tcgttagcca caaccgcaaa
    18841 ccctcgacct gactcacccg cacgagccgc ttcaatggat gcatttagag ccagcaagtt
    18901 ggtttgtgcc gtgatttcta agatagactg agaaagtaaa cgaatttggc ctaccgcctt
    18961 ggctcgttct agcgcttcct tcatcttttc attggccttc cggtaaatct ccttggccgc
    19021 tttattggat tcactagccg cgtgcttcaa tgtttcggct tttacacttg tatcattggc
    19081 agactgagct ctttcttgag ttttaaccga aatgtactct gctgcccgct gcatttcttc
    19141 cgcagaatga ttcatgttct cggtgtatgc cgaagtctct tccatagctg ctgacagctg
    19201 ttcgaccgtg gcagatacat ctctaatccg ctcattgaga tctgtcatat tataattcgt
    19261 ctgatcactc agttggttaa tttggcgtga ctcattgata acccccgtaa tgaccattga
    19321 ggttgaatct gtcatttgtt gaatagcacg cgcaatcaca gcgatctcat tatttccttt
    19381 gagcaaggca ggatcaagtg ctgccgttaa atttccttgg gtaatctcct cacagtattt
    19441 cgtaattgta ctcatccgaa aacggatatt tcgaatggcc gcaaaggaga tggtgataag
    19501 aatagccagc acgagggcca gaactgtgat caaaacaatt gtacgcattt taatctcatt
    19561 ttgcgtattt tgatataagt tggcggattg ctcattgtta taatctgaaa tcgtagtcaa
    19621 catcgtaaca attgccgtac tggatttatt aatccggcct ctctcttccg tgtcatacgt
    19681 tccgctattt tttttgactg ccatgatttg ctcaatatcc tgataatatg tgtctatact
    19741 cccccgtagt tcctcgtaca atttctgttc cttagcatcc aaattccttt gtgagaattc
    19801 atttagtccg gttgtaacgc tatcttttcc tttctgcacc tgcttatact gtttatctgt
    19861 gtactcctta ttgtcgagta tttttgtata attagcccgc atattataga aatcactttt
    19921 gacttcaaga atattcgttt ggtgttgaaa gcgatccaca tacaaaatac cttgaccctc
    19981 tttagcttga tacataccaa taacccctac caacgataca atgagtaaac ccactaagct
    20041 gattacaatc atggagatca tcgttgtcgt aacctttaaa tctctaaaac cttttccttt
    20101 tttagtcctg tctgatagct tgttactcat ccaaacccct ccagatcgtc tatggataat
    20161 agttcacgct gctctcaact ttcacgagtt tccgctcggt ctccttgaca ttgccctcca
    20221 aacaacacaa tgaagcagat cacagaacgt gatgatatat atatttatat atatcggtag
    20281 aaagcgctta aatttataag taagataaca gtgatgcaaa aataaagaat actctgatag
    20341 ccaaattcat atgcggactt gctatgtaac tcaaaacttt agatactcat gggcttaaag
    20401 aatttgctaa acctatctac tatttacttt tagccatatg ataacaagcc ccgatgataa
    20461 gttattccat cggggtatat tatcatatgg ctatggcctt cttctcttta ttgttaagtg
    20521 ttcaatttaa aacctagtgt gataatttca tgcggcttta cagactgaag taactcatta
    20581 gaagaatcca ttacgatgtc ttttccttgt tcttcgagga tattacttct ataaaaatcg
    20641 tactgctgcg gccggggctt gataattaat tcggctatac tatgactcat attgtaccag
    20701 cgtaacagca catcccccga cagctcattc attttcatag aggaaaaggc aagctccgtg
    20761 cttttccaat caaacggcgc ataatctgga gcaactgtac ccgcatgaag ccccgtttgt
    20821 tttacgatcc aaggaatttg atattgatag gcttctgtat acgcgccgga ctgaataccg
    20881 ttgccatcat gtggaatgat ttccagaagg gcggtatgct cacctggaca ttgcgcttcc
    20941 ggcgtcggga accatcccca atcacccagc tcgccaactg agcgaagcag cgttactgca
    21001 atcgtgttac gtccatcacg cagcacttca tattcattca acccgagatt ggccacggtc
    21061 agaccggttt gttccccgct tacatccaca aacgcctgct gatgctgtgt gttgcttggg
    21121 ttttcccact caggtgaggg ttcattgtcc cggattgcaa tttcaaacat ggagtccacc
    21181 cgatgctcac cagagtctag atctgtcgga aacagcgcgc gtagtcggtg gtccttggct
    21241 tggttgttga aggtggtttc catggaaacc cccctgctgt tccgagataa agaaatgaca
    21301 gtccgtatcg tcagcggaac ggtctgtcgg gagcgctgag cctgacgata cgggtaataa
    21361 accagctctc gctgctcctg ccccagcgtt tcatccgcag aggccggtat ttcccaatga
    21421 tggataatct ccatggatgc cagataaggt gtatcttcaa gcacacggat gtcagcgatc
    21481 acatcttcgg tggtcagcgc ctgctctccc tcgggctgtc tgaacatata ctcgttgccg
    21541 atatcaccaa cattttcata tacgccaagg tctttgtagc tgcggcctgt acgcttatcc
    21601 gtcagggtaa aagagccgtt atccgcaatt tcgacgtgaa gcagatcatt ttccatactt
    21661 cgactgcctt gaagaagtga agaggagtca gtctcgacat tgcttctcag ccaagcatag
    21721 gtttttaagc ctagcagggg cacacgttct acctcaaagg taaggcgaac ccgacgagac
    21781 atgtaaggct ggcggaatcg gtcatccggc aaatcataac cgaactgtag cccgaggtcc
    21841 tccaccttgc atgccaccgg acacccttca ctgtccacca gtacgcgccc ggaaagatcc
    21901 actttcttcg ctcgatgaga ggcctcctca agcgtgtatc cttcacggaa gtatagacgc
    21961 accacttcca gttctgccga cactatacca ctgcgttccc agcctgacgt attaaaaatc
    22021 acgagtggca acgcatcttc tccaaagcga ctgaagcccg tcgtatccac tgcttgcgca
    22081 atgacctcaa tgctttcatc cacaatgctc tcggctacat gacggctctt atcaaaccgg
    22141 gtcaccatct cacggtgcac ctcgtccaca ctacaaccgc aaatactgtc atgcggatgg
    22201 ttctgcatca gtgttttcca ggcataggtg aacaaatgat gagggtaagc ctgccccaac
    22261 agatgcgcaa aggttgcaag cggctcagcc actttttcca gcatcacttg tcccaactgg
    22321 ttcatctgtt tcaaatacac ccgggcagaa gccgtattca ccagcgttcc ccagccgtcc
    22381 gtgcgctg
//
