LOCUS       NZ_CP073683            26450 bp    DNA     circular CON 15-MAY-2024
DEFINITION  Paenibacillus sp. S25 chromosome, complete genome.
ACCESSION   NZ_CP073683
VERSION     NZ_CP073683.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus sp. S25
  ORGANISM  Paenibacillus sp. S25
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5958851)
  AUTHORS   Li,T., Mann,R., Kaur,J., Spangenberg,G. and Sawbridge,T.
  TITLE     Transcriptomics differentiate two novel bioactive strains of
            Paenibacillus sp. isolated from the perennial ryegrass seed
            microbiome
  JOURNAL   Sci Rep 11 (1), 15545 (2021)
   PUBMED   34330961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5958851)
  AUTHORS   Li,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2021) Agriculture Victoria Research, AgriBio, 5
            Ring Road, Bundoora, VIC 3083, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 31-MAR-2020
            Assembly Method                   :: Unicycler v. 0.4.8
            Assembly Name                     :: AVR_PaeniS25_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019454085.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 03:29:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,267
            CDSs (total)                      :: 5,136
            Genes (coding)                    :: 5,079
            CDSs (with protein)               :: 5,079
            Genes (RNA)                       :: 131
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 91
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 21 of 57
            Pseudo Genes (incomplete)         :: 38 of 57
            Pseudo Genes (internal stop)      :: 14 of 57
            Pseudo Genes (multiple problems)  :: 14 of 57
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:16:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1865336
            Orig. end                         :: 1891786
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073683.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from AgriBio, 5 Ring Road,
            Bundoora, Victoria 3083, Australia.
            Annotated using prokka 1.14.6 from
            https://github.com/tseemann/prokka.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="9"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16450](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    479..488
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            597..1499
                     /locus_tag="KAI37_RS08155"
                     /old_locus_tag="KAI37_01651"
     CDS             597..1499
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280775.1"
                     /locus_tag="KAI37_RS08155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01651"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_023987954.1"
                     /transl_table=11
                     /translation="MTLQQLKYVIEVANRGSMNEAAKRLFISQPSLSNAIRDLEEEIHI
                     TIFERTNKGISLSKEGVEFLGYARQVVEQAELLESRYLDAKPSPQHFAVSTQHYAFAVN
                     AFVNLVNQYGQEEYELALRETKTHEIIQDVKSLRSEIGILYLNEFNAKVINKLLKDANL
                     QFNSLFTAKPHIFISANNPLSRQSIVTIDQLHPYPYLSFEQGEYNSFHFSEEILSTLSH
                     PKSIRVHDRATLFNLLIGLNGYTISTGVISADLNGNDIISVPLECDESINVGWICHKNA
                     ALSKLATVYVEALHEAIGE"
     gene            1623..2762
                     /locus_tag="KAI37_RS08160"
                     /old_locus_tag="KAI37_01652"
     CDS             1623..2762
                     /EC_number="2.1.1.14"
                     /GO_function="GO:0003871 -
                     5-methyltetrahydropteroyltriglutamate-homocysteine
                     S-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017425888.1"
                     /locus_tag="KAI37_RS08160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01652"
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="WP_076292518.1"
                     /transl_table=11
                     /translation="MSSILDNASQRKVTPFRHDMVGSFLRPQAIKDARIQFQNNEISAD
                     ELRKIEDNEIIKLVEKQKSVGLQAVTDGEFRRSWWHLDFMWGLDGVEKVQLSNGYQFQG
                     VETRAETARLSGKIGHSRHPFIEDFKFLKQVAGEDAIARQTIPAPAQFLAELLRGENKE
                     TTDTYYSNLDELVTDIAKAYKSVIQALYNEGCRSLQLDDCTWGMLCDKNYWEARQHAGE
                     NVEDTKKLFARVNQETVKDLPADLVVTTHVCRGNYHSTWASSGGYEPVAETLFGIDNID
                     GYYLEFDTDRAGDFTPLKHLKDQKQVVLGLVSSKTGELEDKQTVINRIKEATQFVDINH
                     ICLSPQCGFASTEEGNVLTEEQQWKKLAFIKEIADEIWK"
     gene            complement(2834..>3304)
                     /locus_tag="KAI37_RS08165"
                     /pseudo=""
     CDS             complement(2834..>3304)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611182.1"
                     /locus_tag="KAI37_RS08165"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KLVTDITYIRAGERFVYLSVIQDLFSYEIVAWRLSERNDLALVSE
                     TLDVLSKNVNMEGVILHSDQGFQYTSKPFNRKLKRLGMLGSHSRRGNCLDNACIESFFS
                     HLKTEKIYLTKPGTLAEVEQHVREYILFYNENRFQKKLNNRSPIEYRETVAA"
     gene            complement(<3319..3414)
                     /locus_tag="KAI37_RS26655"
                     /pseudo=""
     CDS             complement(<3319..3414)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013676.4"
                     /locus_tag="KAI37_RS26655"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="Tn3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTDAYPNLQPILTRPINWELVRQQYNQMMKYA"
     misc_feature    3577..3590
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.3"
                     /tool="antismash"
     gene            3744..>4727
                     /locus_tag="KAI37_RS08170"
                     /pseudo=""
     CDS             3744..>4727
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370239.1"
                     /locus_tag="KAI37_RS08170"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYNTPTVPAKFEDYLKLNDMTLAQFAEYSGVHQRTLSNWIIQHRP
                     LSVQQLDRITVTMGLSEGHFYDLYIENYIIDLPLNMRRIEPLLYRCTELDKLEAIRRLV
                     GHIMDKLMYFPRLYQIAETLFSQRQHAAALFNCYNVA"
     misc_feature    4848..4859
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.49"
                     /tool="antismash"
     gene            4974..5615
                     /locus_tag="KAI37_RS08175"
                     /old_locus_tag="KAI37_01655"
     CDS             4974..5615
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="KAI37_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01655"
                     /product="response regulator transcription factor"
                     /protein_id="WP_179085888.1"
                     /transl_table=11
                     /translation="MLHVETDSVWRDLICKYVKQQPDMKYVASIATEQEAIHFAEQYKV
                     DVIVMDVTLTSSQYDGLDAVREILMRKHVSIIILSSVDNLEVIADSFSVGAVNYIMKKN
                     YTDLATAIRDAYHNRVAIHPDAASVLCDEFRKLRLEELERSLTRTERQVIVYLHEGYSK
                     SKISEVLHVEPETIKTHVKHILTKLDVGSCKDAVKVARRRGLFDNNYVMR"
     gene            5797..5970
                     /locus_tag="KAI37_RS08180"
                     /old_locus_tag="KAI37_01656"
     CDS             5797..5970
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881441.1"
                     /locus_tag="KAI37_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01656"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_081047461.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.1e-12, bitscore:
                     46.0, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNNQFDLDVQVSKNVGKIEPQVTSVFACTPGCITGPNCGSSECG
                     TVPCGKTTSRLC"
     CDS_motif       5797..5862
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSNNQFDLDVQVSKNVGKIEPQ"
                     /locus_tag="KAI37_RS08180_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5863..5970
                     /prepeptide="core"
                     /locus_tag="KAI37_RS08180_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="7.60"
                     /molecular_weight="3257.7"
                     /monoisotopic_mass="3255.5"
                     /core_sequence="VTSVFACTPGCITGPNCGSSECGTVPCGKTTSRLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNNQFDLDVQVSKNVGKIEPQ"
                     /leader_location="[5796:5862](+)"
                     /alternative_weights="3275.8"
                     /alternative_weights="3293.8"
                     /alternative_weights="3311.8"
                     /alternative_weights="3329.8"
     gene            6127..6855
                     /locus_tag="KAI37_RS08185"
                     /old_locus_tag="KAI37_01657"
     CDS             6127..6855
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002192338.1"
                     /locus_tag="KAI37_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01657"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_053325120.1"
                     /transl_table=11
                     /translation="MTELILEVDRVTKRIGNKTLIQETSFKLEKGMIYGFIGPNGAGKT
                     TLMRLMTGLIQPTSGAIRIGTYDVQKQRKQALANVGAIIESPIFFEYMTGRQVLRNLSR
                     LHSEIRSADREKHIDQLLQSVELQSRADDKVKTYSLGMKQRLGIAQAMLGSPDLLLLDE
                     PSNGLDPLGMRELRNLILRLRESRGLSFFVSSHLLDELQLMCDHLIVIRAGVVIWTGNV
                     NDLIVDGQRLEDAFLELMLS"
     gene            6852..7685
                     /locus_tag="KAI37_RS08190"
                     /old_locus_tag="KAI37_01658"
     CDS             6852..7685
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="KAI37_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01658"
                     /product="ABC transporter permease"
                     /protein_id="WP_053325121.1"
                     /transl_table=11
                     /translation="MKVLIRIEFEKLIHQKWAWFILVSCIPFAYALITYFVWVDQRHLP
                     DSPFYVAASMSASRGMKESIYLFGNLMVALLAGLLYTEEFQGGKLRMFFLRSYSRGQIF
                     VSKWMIMNLFILLMMVILGVSFTIFGVMKLPSPPEVMISGNRIPSTNVAILFYTLKQYA
                     LDFATLIGGGGLFIWIAMYCRTAARTIGIAMIYIIISIFATSIFDPGSPLITENAFLLA
                     LIYAGLIPGMQIVGVEKALTGDEYAQISIAVGLVIYFFVCIVAARRKFTRADYLN"
     gene            7698..8465
                     /locus_tag="KAI37_RS08195"
                     /old_locus_tag="KAI37_01659"
     CDS             7698..8465
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KAI37_01659"
                     /product="hypothetical protein"
                     /protein_id="WP_053325122.1"
                     /transl_table=11
                     /translation="MNTGLWISELERIWKGKRIRAFGCVYLLALLIDIGFLRLTGGIKI
                     DLSSWFSVDALNLPVFIMKDMSFLLQLFVLPGLFVESLADEIHSGAYRIYMLRSFDRYQ
                     HWLVKLLTQIVLIVSFIFGTTLVSLACGWLFFSHPQSTVVYLVPESIGYGNVLWLTIQY
                     DLLLVLTSIAVLVICSVFSILITRVSIVYACTILGLLGSYVIVSELRFLHDPFVSILRV
                     LCGQGSMIFWVYLTGIVVICPIISFWIWSKRGM"
     gene            complement(9228..>9470)
                     /locus_tag="KAI37_RS08205"
                     /old_locus_tag="KAI37_01660"
                     /pseudo=""
     CDS             complement(9228..>9470)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="KAI37_RS08205"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01660"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="SVAQVARELGISTNTLYRWKAEYVQHGKQAFPGSGNLSPADQAMR
                     GLQKQIRELQEENEVLALLRKRPALIFSFIHNHHF"
     gene            10001..13189
                     /locus_tag="KAI37_RS08210"
                     /old_locus_tag="KAI37_01661"
     CDS             10001..13189
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="KAI37_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01661"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_220031039.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-179,
                     bitscore: 596.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.8e-11,
                     bitscore: 42.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-36, bitscore:
                     124.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEPNIYRALDFFMIRTPVLPFNLFIQCFPSDWKDQEELKRYSL
                     NKLVELSNDPIIREAIAVASPSLLESLSHLGNDQNARKKAQAIKGFMRYLLRMMTRPTP
                     FGLFSGVTYGQFAEQSQMNIEGIATYRKRVRPDMEWLLKIVDKIEKQREVVVQFRIQRN
                     SLIYRQGERAKIPYVARYGDLGVGESDSVSVRASAVFDLVMEASMNPIPYLELVSRIKS
                     AFMEAELDTIHHYIWQLFEQEFLISELRPPTTSIEPFDHILSVLDRVEGIDEWKVALNE
                     IRRNIRSYNSRSIGQGEEQLLQLRQMMNALAEVKTTVQVDLSLEDRSVTLPSQVREDVE
                     KVAHLFSRISTRKYRHLEEYCNEFLEKYGPYREIPILELLDEEIGLGAPATYQNPSSVH
                     RQLKNPSVPFSTKCEQLLFKWFVSCMHQGEQEIVLTNERIQQILEDESDKTTSELIPTP
                     SMELYFLMVVQDQEALNRGEYTLVLGPNPGSSGAGKTFGRFIDLMGVSFKNMFNEIHEE
                     EQRLSPGKLLAEISYLPSAARSTNVVLTENFRTYEIGIGTNHTVPEDQQIHVSDLMVGV
                     RDDKFYLKSRKHNCEVIPTAGHMLNYQGAPNVYRFLVEVSQEGYRQWSTLEWGVMDQSP
                     FTPRLRYGNIVLSPATWRIQLSDKTSERESEEKLALLVREFSIQWKVPRYVYMTQFDNR
                     ILFDMEHSLHVEEICKDLKSNGQVTLIEHIGGFEDMPIQRSDGRLTAEFVFPLVRRTEE
                     MDLTQAEVAVSKETEISRLTVVDASQRVQLPGGSWFYAKFYGIDSRQDEFIGRQWGDFV
                     QKCREAGVIEQAYFIRYSDPTRHIRVRFNMPSGNDISSFIPIFHEWTTMLLQDGMINKV
                     VVDTYEPEIERYGGPELMLLAERMFACDSDVTANLVRLLRFKQIQLSQEVVAVCSVIQY
                     MTQFGYNEQKVYELLNERFDVKEYLDDFRNERRLFLQLLGRDSSELVSLHQEGKLIHQI
                     GQHREEAVKCYQQALLEHERQGTLMNNKDDILFSVIHMYLNRLIGIDRDKERKVMIMAR
                     HALNSLLQYWRKSQ"
     aSDomain        10487..10756
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KAI37_RS08210_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.90E-14"
                     /identifier="RREFam001.1"
                     /label="KAI37_RS08210"
                     /locus_tag="KAI37_RS08210"
                     /protein_end="252"
                     /protein_start="162"
                     /score="42.8"
                     /tool="antismash"
                     /translation="NSLIYRQGERAKIPYVARYGDLGVGESDSVSVRASAVFDLVMEAS
                     MNPIPYLELVSRIKSAFMEAELDTIHHYIWQLFEQEFLISELRPP"
     gene            13186..15051
                     /locus_tag="KAI37_RS08215"
                     /old_locus_tag="KAI37_01662"
     CDS             13186..15051
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="KAI37_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01662"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_053325124.1"
                     /transl_table=11
                     /translation="MNFIWKGCQHELASLWKTVRHGLQLFQLIFHMNKQYMIPSMILHI
                     IQGAVPVMTLMVTQNLLNSVSVGWKEGEYWVLSQFVWFIVIYVLKNFIDVAQSYVEGNL
                     QAVISNSMNVMICEKSTTLGLADFENASINDQLKRVSQEATYRPYQLYSQMAGIASGLI
                     TLISSAILLVLWKWWVVLVILMISTVSIYSIFKINREQFQIYLDRTPQNRESWYMTYLL
                     TNDSTFKEVKIFQLGSYLLNRYRDLLHGFFLVDRRILLKRIRVTFLYDMLEMVALFWLI
                     GLVIHETFIGAMMIGSLYGYIQAIMLTQNQTKGVIQGLVQFSQNNLYMEQLLLFLQLPT
                     SDPVHRQKQFPNATELSCDANASIQITQISFDQVSFAYPGQDSDTIREVDVTFKKGQTV
                     AIVGKNGSGKSTLVKLLMQLYTDYRGTIQVNGRNVLDYDLQQVQERMGVVFQDFVHYEM
                     SARHNIGFGSLAELEQDERLMDAAKVAAIDQMIANLPSGLDTQLGKWFDEGHQLSGGQW
                     QRIAIARAILRSADVYVLDEPSSFLDPLAERDLLQLFIHLMRDTIGIFITHRISSARLA
                     DQILVMEDGRIIEQGSHAELMRLGGVYAQMYQVQASSFAEEVGVN"
     gene            15068..16450
                     /locus_tag="KAI37_RS08220"
                     /old_locus_tag="KAI37_01663"
     CDS             15068..16450
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="KAI37_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01663"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_220031040.1"
                     /sec_met_domain="LANC_like (E-value: 9.5e-57, bitscore:
                     190.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAASAVSTQWIPLKGEVRKQVAQVLQAIVQRYKDPDQVRAQMKQ
                     VPGQVIEGKQVARWSDTSFSGGFTGICVLMGQLDQLYPDEGWDMVGHSYLQKIQQVIEQ
                     QGIHTLSLYSGLAGILIGVRALSRKNTRYQGMLDTLASWFEEAVLNYVEICKNQWEEGQ
                     LRISQYDTIEGLTGIGRVVLAFSDRPQMKIIWQRIVEVFHIFCGEKDYLGHRIPAWHIP
                     SANQFLEHEKVQYPNGNFNVGLSHGISGPLAFLSLSQLQGMTTEAMRADLRRLTEWTCR
                     WRVSGEAGTFWPGRVAVEEVLQGELHPSSIRDPWDSWCYGVPGIARSIWLAGQAMDNQE
                     WSAIGLQAYVEIENRIQTMGGLTASTLCHGVGGLLHMIQRMYSDTGHVTLGVMRDELVV
                     AVLDKYAAESKFGYYDEHFVNGKYEQVDEAGFLTGAAGVALVLASLLYEESPDWDMALL
                     IR"
     gene            complement(17211..17633)
                     /locus_tag="KAI37_RS08230"
     CDS             complement(17211..17633)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013753.4"
                     /locus_tag="KAI37_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_220031450.1"
                     /transl_table=11
                     /translation="MYGVDFFAHQTRVCLQTIKQAKSLKDEDLKTAKAYHLKLTFSKLW
                     KQETPEKAEVFLDSWYFWATHNQIPDMVKSAKTIRQHATGILKWFTSKITNGIMEVING
                     LIQCAKRRAHGYRSLKNLKTTIYLFAGRLKLKKVEI"
     gene            18074..18667
                     /locus_tag="KAI37_RS08235"
                     /old_locus_tag="KAI37_01665"
     CDS             18074..18667
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KAI37_01665"
                     /product="hypothetical protein"
                     /protein_id="WP_220031041.1"
                     /transl_table=11
                     /translation="MGILDFRSNNEVHQPVILALELVKRYSDTGQHYLPLLEDVPIDGV
                     IRNVNREIIVEKDEKGQERINRMNYEISVLQALRDKLRCKEIWAVGANRYRNPDDDLST
                     DFEERREENYKALKQSLDAHAFIEMLKEAMKDGLEKMDRGLSKNEKVRITEKGNGWISL
                     SPLEPQTEPVNLSRVKSELLRPDTSPILKTKKSF"
     gene            complement(18664..19002)
                     /locus_tag="KAI37_RS08240"
                     /old_locus_tag="KAI37_01666"
     CDS             complement(18664..19002)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309639.1"
                     /locus_tag="KAI37_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01666"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_076292525.1"
                     /transl_table=11
                     /translation="MQDKEVLKLVGARIRVLRKEKGLSQEALGEKGGFHFTYIGQIERG
                     EKNVSLINVAKIAKALDVNLIQLFSYVSEDPKIMESDEDVIQIITMLKKSSPEKVRLAK
                     NVIREITN"
     gene            19727..19825
                     /locus_tag="KAI37_RS08245"
                     /old_locus_tag="KAI37_01668"
     CDS             19727..19825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599622.1"
                     /locus_tag="KAI37_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01668"
                     /product="hypothetical protein"
                     /protein_id="WP_014599622.1"
                     /transl_table=11
                     /translation="MGEVGYGGAWTSTGAILVLFILLVIITKSFLI"
     misc_feature    complement(19913..19927)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.08"
                     /tool="antismash"
     gene            20046..20495
                     /locus_tag="KAI37_RS08250"
                     /old_locus_tag="KAI37_01669"
     CDS             20046..20495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370423.1"
                     /locus_tag="KAI37_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01669"
                     /product="DUF6386 family protein"
                     /protein_id="WP_220031042.1"
                     /transl_table=11
                     /translation="MMNTASSPFQFTTDTATLCLFDTQALKHRLDDDPDWWSIEEDELG
                     ELNKGNVAFLNLGADGTYEVGMTDHIDKPAVRLFLKVPSGNLFIGAGEEATGGGLEPEC
                     VWGGTFLSVQPGLYECLASKEGNRIYLSLKKGSEGSNSFTGLIRL"
     gene            complement(20629..21759)
                     /locus_tag="KAI37_RS08255"
                     /old_locus_tag="KAI37_01670"
     CDS             complement(20629..21759)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349008.1"
                     /locus_tag="KAI37_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01670"
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_220031043.1"
                     /transl_table=11
                     /translation="MKRITALVILSLLLLVSPIYAAAPAPMLVYVDQSNHSFIPLRLLN
                     SYEGITLNMTAADKKIEIAQGNTRITLFTGKSTAKVNDQTVRLQNAPFNDNGSTYVPLQ
                     FISQYLNLQVSWQKETSAVRIKQGTTSVTLPVLTGKLPGNTTPITTAHKSFKVGSRTFS
                     AKVVTISMLHPKVSLDVALAGNTIGKVEDLSSLAKRNQAVVAINGTFFDAYTKSSYKTP
                     YGYLVSHGKILKKSSGDQRTVFTYDANHLSELMSGSAFEQRLSQGNIEGALQAGPRLVT
                     NGQVSLNVKAEGFKDPKILTGGGARSALGMSRDHKLILLTTSGATIPQLAQMMKQAGAY
                     QAMNLDGGASSGLYYNGSYLTTPGRQISNAIIVKYQ"
     gene            21892..22362
                     /locus_tag="KAI37_RS08260"
                     /old_locus_tag="KAI37_01671"
     CDS             21892..22362
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686877.1"
                     /locus_tag="KAI37_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01671"
                     /product="hypothetical protein"
                     /protein_id="WP_076292529.1"
                     /transl_table=11
                     /translation="MSRYETRLEDYRRRERPSYRVFEGLQELVRSVGQLHNNWLYVNVD
                     QWDQDPVHTPIYYWDEHWLEECAEKGTAITNEQDEYIPECVSDRQVQTWFELATFESIV
                     EVLKAAGQPVTLQMVIMAVKYYDKRDAYLDYEEVKAVTDLWSVLTKVRNHLT"
     gene            22417..23730
                     /locus_tag="KAI37_RS08265"
                     /old_locus_tag="KAI37_01672"
     CDS             22417..23730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686878.1"
                     /locus_tag="KAI37_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01672"
                     /product="hypothetical protein"
                     /protein_id="WP_220031044.1"
                     /transl_table=11
                     /translation="MSWLNHEMAAKWRQEGKRYAADVNEFVRVGMESEWQQEQSEPKRD
                     ERPKMAKDIFRMIQEANQAGEMEQLRREIPAASWPLTPAFEEALQAVRPIAFVNGGNEI
                     IVHAGNPRERGTIYVTGKDRILQIPGLHRVGCSPDGTYFALVDGQGIRIVRQPDRNLQG
                     EETAHFQWKDIQGRLKASIPDLECLGDEDHPEDILDEVIPFGDGQRLLLVCGYGVYLLA
                     GDQVDLIHPKASERRELKLEDTIVDMAHGAVSRDGRWIAYGSQMSEHMLMDLSDKTVHT
                     LEPSSSYPHYALFSKDDLDVWYNACHFYNGATIQVSIAEMEQGLAQNKEEWPMMNEEMR
                     VYAATALTQGSILGDAYGYLRLIDREGRELWRYFVGSTISGLAVSPDEGMLAVGTYGGM
                     LHLIDLQSGTKDEYSIGTAPFHETARWVIWRNYEPLRW"
     gene            23886..24509
                     /locus_tag="KAI37_RS08270"
                     /old_locus_tag="KAI37_01673"
     CDS             23886..24509
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370427.1"
                     /locus_tag="KAI37_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01673"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_220031045.1"
                     /transl_table=11
                     /translation="MDKKADIRTSMKELFAQMDEAFFMDVEENVPIEMRDGNVDEEGWI
                     KWKPLPSQITEQEVREMEEKYHFELPPLLRSFIMSYHYVSLQFDNESIPGVYWSDCTFV
                     EFPRLPVGQGLKAFYDLLDQWSPLLSAGYIPFAIAEDDQGPVCLNAGSRHKDGDYPIVW
                     FFHEDLQHLDEDELRIRSNLLPHVQGLFPSSVEMFNVMFKHIRH"
     misc_feature    complement(24605..24619)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.05"
                     /tool="antismash"
     misc_feature    24858..24873
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.57"
                     /tool="antismash"
     misc_feature    24906..24919
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.22"
                     /tool="antismash"
ORIGIN
        1 tcaaccccaa cctgcaaacg acagagtttg gttgggagat tgatccggtc ggttttagaa
       61 ccacattacg ccaaatttat tctcgctacc acttgcctct aatcgtgaca gagaacggct
      121 tgggcgcttt tgacaagctt gaagaagggg atgtagtgaa tgatccttac cgcattgact
      181 ttttcaagaa gcatattgag cagattcaac tggctattac agacggtgta gaagtattcg
      241 gcttctgtcc gtggtctgca atagatcttg ttagtaccca tcagggctcc agcaagcgtt
      301 acgggtttat ttatgtggat cgtgaggagt ttgatctcaa ggatctgcgt cgtattcgta
      361 aacaaagctt ctattggtat caaaagctga tctccacaaa cggtgaaatt cgttaattaa
      421 tgcagccgtg aaaaagcacc tccttgaaat ggaagatttc catttaggga ggtgtttata
      481 tttttttaaa ccttagggga gaggctgatt tcatttaagc aacaattatc ccttttccag
      541 aagtgtgatt atgtattata taatagaaga aacacaaacg gaaaggacat catgcattga
      601 ccttacaaca attaaaatat gtcattgagg ttgccaatcg tggctccatg aatgaggcgg
      661 cgaagcggtt gttcatttcc cagcccagtc tgtcgaacgc gattcgtgat ttggaggaag
      721 aaattcatat caccattttt gagcgtacca ataaggggat ttctttgtcc aaggaaggcg
      781 tggaatttct cggttatgca cgccaggtcg ttgagcaggc ggagttactg gaaagtcgct
      841 atctggatgc caagccttca ccacagcatt ttgctgtgtc cacgcagcat tacgcttttg
      901 ctgtaaatgc atttgtgaat ctggtgaatc aatatggtca agaagagtat gaattggctt
      961 tacgagagac caaaacccat gaaatcatac aggatgtcaa aagcctgcgc agtgagattg
     1021 gaatcctgta tctgaacgaa tttaacgcca aggtcatcaa caagctgcta aaagatgcga
     1081 atctgcaatt caatagcctg tttacggcca agccgcatat ttttatcagt gccaataatc
     1141 cgctatctcg acagtctatc gtgaccattg atcagcttca tccgtatccg tatttgtcct
     1201 ttgaacaagg ggagtacaat tcctttcact tttccgagga gattctcagt acgttgtcac
     1261 atcccaaaag cattcgtgtc catgatcggg cgaccctttt taatttgctc attggcttga
     1321 acggctatac gatttctacc ggggtgatca gtgcggatct gaacggtaac gacattattt
     1381 ccgtccctct ggaatgtgat gagtctatta atgtgggatg gatttgccat aaaaacgctg
     1441 cactctccaa gctggctacc gtctatgtag aagcgctgca tgaggcgata ggggaataaa
     1501 agattggata tagccttagg ttataactag ctatagttta ttggagttac cttataactg
     1561 aaaatgtatg ttatctttct tacaagaact tcactacaga agcgaaaaag gagataaccc
     1621 taatgagcag cattcttgac aatgcatccc aacgtaaagt gacccctttt agacatgata
     1681 tggtcggcag ctttttgcgc ccgcaagcga ttaaagacgc cagaattcaa tttcaaaata
     1741 atgaaatctc tgcggacgag ctgagaaaga ttgaagataa cgaaattatc aagctagtgg
     1801 aaaagcaaaa atccgtagga cttcaagccg tgacagacgg tgaattcaga cgctcctggt
     1861 ggcatcttga ttttatgtgg ggtctggacg gcgtggaaaa ggtacagctt tcgaacggct
     1921 accaattcca gggtgtggaa acaagagcgg aaaccgcacg cttgtccggt aaaatcggac
     1981 attcccgtca tcctttcatt gaagatttca aattcctgaa gcaagtagca ggtgaggatg
     2041 cgatcgcgcg ccagacgatc ccggcacctg cgcaattcct ggccgagctg ttgcgtggcg
     2101 aaaataaaga aacaaccgat acgtattaca gcaatctgga tgagctggtg acggatatcg
     2161 ccaaagctta caaatccgtg attcaagcgt tgtacaatga gggctgccgc agtttgcaac
     2221 tggatgattg cacatggggt atgctctgtg ataaaaacta ttgggaagct agacagcatg
     2281 cgggtgagaa tgtggaagat accaaaaagc tgtttgcccg tgtgaatcag gaaacggtga
     2341 aggatctccc agctgatttg gtcgttacga cccacgtatg tcgtggtaac taccattcca
     2401 cctgggcatc ttctggaggc tatgagcctg tagctgaaac cctgttcggc atcgataaca
     2461 tcgacggcta ctacctcgaa ttcgataccg accgtgcagg tgatttcaca ccgcttaagc
     2521 atctgaaaga tcaaaagcag gtcgtactgg gcctcgtttc ctccaaaacg ggtgaactgg
     2581 aagacaagca gacggtcatt aatcgtatta aggaagcgac tcaattcgtc gacatcaacc
     2641 acatctgcct cagcccacaa tgcggttttg cttcgacaga agagggcaat gttctgacag
     2701 aagagcagca gtggaaaaag cttgctttca ttaaagagat tgcggacgag atttggaagt
     2761 aagggtttag gagaaatacc ttggagaaat ttggtcatac ccctgtcaag tagacagaac
     2821 taaaaagaca tctttaagcg gcaaccgttt ctcggtattc aatcggggaa cggttgttta
     2881 attttttctg aaatctattt tcattataaa ataagatgta ctcccgtacg tgttgttcta
     2941 cctccgctag ggttccgggt ttcgttaaat aaatcttctc tgttttaaga tgggaaaaga
     3001 aggattctat acaggcattg tctaggcaat ttccacgcct tgaatggctt ccaagcattc
     3061 caagccgctt aagtttgcgg ttaaacggct tggaggtata ctgaaacccc tggtctgaat
     3121 ggagaatgac accctccatg ttcacgttct tacttagaac gtctagcgtc tcgctaacta
     3181 gagcaaggtc atttcgttcc gaaagacgcc aagccacaat ttcatagcta aacagatctt
     3241 gaatgacaga gagatataca aaccgctctc cagctcgtat gtatgtaata tcggtaacca
     3301 gcttgggcgt aaagcagtag catacttcat catttggttg tactgctgcc taaccagttc
     3361 ccaattgatc gggcgagtca gtatcggttg caaattcgga taagcatcgg tcatgcctag
     3421 ttccggtcta atagcagccc aggggcgttt tccaatcagc aatatataaa tcgaaacgtt
     3481 ttagttcgtc tatatattgt aactacgagc gttggaaatt gaattatgaa aatactgaca
     3541 taagaaaaat ggcgataccc ttaataatga catcattgca aagtatctaa ataggtattc
     3601 taagtaaatt ttgatatgta tgtgatttta ttctagaaaa tggtatgatg aattgcggaa
     3661 aggtctatgc gattcatctg attgcagtag tcctcgtttc atgagttgat tttctatatg
     3721 ttcctgataa ggggtggtta tttttgtaca atacacctac agttccggcg aagtttgaag
     3781 attatctaaa actaaacgat atgacactgg ctcaatttgc ggaatattca ggtgtccatc
     3841 aaagaacact tagtaattgg attattcagc atcgtccact ttccgtgcag cagcttgatc
     3901 gaatcactgt gactatgggt ttatcggaag gtcactttta cgatctatac atagaaaact
     3961 acatcattga cctcccccta aacatgagac gaattgaacc attgttatat cgttgtacgg
     4021 agctggacaa gctggaagcg atccgtcgat tggttggaca tattatggac aagcttatgt
     4081 actttcccag actatatcaa attgcagaaa cattattttc acagcgacaa catgccgctg
     4141 cactatttaa ctgttataat gtggcataac tagaaaaata taagtactcc gagcgcttgg
     4201 cagtctgtca gtatcgtata ttcacgattc aggttggaga cgatcaaagc cgaaatgtca
     4261 gggcagtagc cgtttttgaa gcttttgtcg aacgactgga tgaaatagag cagcttaacg
     4321 tattgaagga tctggctaat gtataggtct ttgcgtaaat gggacaagtt tgacgaaatg
     4381 gcgaggaaat gagggctaaa gcggaaatcc aatattcgat gaaacatcaa caagaaagtc
     4441 gagagcatga tgattccgcc aagaagctaa gtcgtcccat ctttgtgtac atcatttatg
     4501 ctgatctact gtgtgctagt gtctgtgaag cccaaggcga ttatcaacaa gttctacaat
     4561 atacatatga ctacgctgat ttagattggg ccatagagac tgatgaggat acccgacact
     4621 ggattggttt gtttcaacaa tgggcggaag gcaatactta cgtatataag cttttgtcgg
     4681 gagatataaa tgtactacat gattatattg aatatatcgc tgcaacatgg ggtagttcca
     4741 gcgtagctga tactacccca tgtaaatgaa atgtgaaaaa cgtattttta tgggtaacat
     4801 ctctggtgct gttgatcgtc gtatttcaag gaggctcgta cgtttaagaa aacgttgtct
     4861 agtaccaaga attacaaaat gaaaaggagg tacttgctgc gctaaaaagt atacctttag
     4921 gtttgttgtt aggaaatatt gcgcggctat tacaaattat ggagtttatc agtgtgttac
     4981 atgtggagac tgattcggta tggcgtgatt taatctgcaa atatgtgaag cagcagccag
     5041 atatgaaata tgtcgcaagt atagcaacgg agcaggaagc cattcatttt gcagaacagt
     5101 ataaagtcga tgttatcgtg atggatgtaa cactgacctc ttcgcagtat gatgggttgg
     5161 atgcagtgag agagattttg atgagaaaac atgttagcat tattatctta tcttcagtag
     5221 ataatttgga agtgattgca gactccttta gcgttggagc cgtcaactat attatgaaga
     5281 agaactacac ggatcttgct acggctattc gcgatgcgta tcataatcgc gtagcgattc
     5341 atcctgacgc tgctagcgtg ctgtgcgatg agttccgcaa actaagattg gaagagcttg
     5401 aacgctccct tacgcggacc gagcgacaag taatcgtgta tctacacgaa gggtactcta
     5461 aatcaaaaat aagcgaagtt ctgcatgtcg aaccggaaac aattaaaaca catgtgaaac
     5521 atatactcac aaagctagat gtgggtagtt gcaaagacgc agtcaaagta gcaagacggc
     5581 gaggattgtt tgacaacaat tacgttatgc gatagggggg agaaaaatgt aaccctagta
     5641 aaaaatagaa tctataatat aatttgtaat agaggagctg gatcgcgcta tctgtattgg
     5701 cgccggtata gattgctatc actgcttctc taattaggaa tttgtctagc ttggtgaaat
     5761 accgagagac aatgaaaatc tgaggaggta gttattatgt ctaataatca atttgatctt
     5821 gatgtacaag taagcaaaaa tgttggtaaa atcgagcctc aagttaccag tgtgtttgct
     5881 tgcactccag gatgtattac tggaccgaat tgtggatcta gtgagtgcgg aactgtgcct
     5941 tgtggtaaaa caacatcgag actttgttaa taaaaaacca agtatgatca tatgtagtca
     6001 gtaatgttaa cgttctgcag gcttctgtct agttgttagt cgtgtgggct aatgcaagac
     6061 agatgtctgc acttttttgt agtgaaagga agagagtaac caatatagca tacagaggtg
     6121 tgactgatga ccgaactgat tctggaagtg gatcgtgtga cgaagcgaat aggtaataag
     6181 actcttattc aagagacgtc ctttaaattg gaaaaaggta tgatctacgg atttataggc
     6241 cctaatggag caggaaaaac aacattaatg cgattaatga cagggcttat ccagccaaca
     6301 agcggagcga ttcgcattgg gacatatgat gtgcaaaagc aaagaaaaca ggcactagct
     6361 aatgtagggg cgattataga atcccccatc ttttttgagt atatgaccgg aaggcaggtg
     6421 cttcgaaatt tatctcgatt gcactctgaa attcgctcag cagatcgaga aaagcacatc
     6481 gatcagttgc tccagagtgt ggaattgcag tcccgagcag atgataaagt gaagacttat
     6541 tcgttaggga tgaagcaacg attaggtatc gcgcaagcta tgttagggtc ccccgacctg
     6601 ctgcttttgg atgagccatc caatggactt gatccgctag gtatgcggga acttcgtaat
     6661 ctgatcctcc ggctgaggga atcacgaggt ttatcattct tcgtatccag ccaccttcta
     6721 gatgagctgc aactcatgtg tgaccatctc attgttattc gagcaggggt ggtcatatgg
     6781 acggggaatg tgaatgattt gattgtggat ggtcagaggc tagaagacgc attcttggag
     6841 ttgatgttgt catgaaagtg ttaatcagga ttgaattcga gaagttgatc catcagaaat
     6901 gggcatggtt catattagtt tcttgcattc cgtttgctta tgcattgata acatattttg
     6961 tgtgggttga tcagcgacat ctacctgata gcccattcta tgtagctgcg agcatgtcgg
     7021 catcgagagg gatgaaagaa agtatatatt tatttgggaa tttaatggtc gcgctgttgg
     7081 ctggtctctt atacacagaa gagtttcagg gtggtaaatt gcgaatgttt tttttaagaa
     7141 gctattctcg gggtcaaatc tttgttagca aatggatgat aatgaattta ttcatcctgt
     7201 tgatgatggt tattttaggc gtatcgttta cgatttttgg cgtaatgaaa cttccatctc
     7261 ccccagaggt aatgatatca gggaatagga ttccttccac aaatgttgca atactattct
     7321 atactttgaa acaatatgca cttgatttcg ctacattgat cggggggggc ggtttgttta
     7381 tttggattgc catgtactgt aggactgcgg cccgtacaat tggtattgcg atgatctata
     7441 tcattatatc aatatttgct acaagtattt tcgatccggg aagtccttta ataacggaaa
     7501 atgcattctt gcttgccttg atttatgcag ggttaattcc aggtatgcag attgttggtg
     7561 tggagaaggc attgacgggc gatgaatatg cacaaatttc aatagccgtg ggtttagtta
     7621 tttacttttt cgtatgtatt gtagctgctc gtagaaaatt tacgagagca gattatttaa
     7681 attaggagtg ttggcgtgtg aacactggct tgtggatcag tgaactggaa cggatatgga
     7741 aggggaagcg gattcgagcg tttggatgcg tttatctact cgctctattg atcgatattg
     7801 gattcttacg tctaacaggc ggtattaaaa ttgacctaag ctcgtggttt tcggttgatg
     7861 cactaaatct gccggtattc attatgaagg atatgtcgtt cttgttgcaa ttgtttgtgt
     7921 tgccgggctt atttgtagag tcgcttgctg atgagataca ttcgggtgcg tatcgcatat
     7981 atatgttacg ttcgttcgat cgctatcagc actggctagt taaattactt acacagatcg
     8041 ttttgattgt ctcgtttatc tttgggacaa cgctggtctc gctagcgtgt ggatggttgt
     8101 tcttttctca tccgcaatcg acagtggtgt acttagtgcc agaatcgatt ggatatggca
     8161 atgtgttgtg gctaacgatc caatacgatc tccttcttgt actgactagc attgcggtgc
     8221 ttgtgatatg cagtgttttt tctatcctta tcacacgagt ttcaattgtg tatgcatgca
     8281 ccattttagg gttgcttggc agttatgtca tcgtctctga acttcgtttt ctgcatgatc
     8341 cgtttgtcag tattttgaga gtactttgcg gacaaggaag tatgatcttc tgggtgtact
     8401 taaccgggat tgttgtgata tgtccaatca tcagtttctg gatttggagt aagagaggaa
     8461 tgtaaaagca cgcattattg ttgatacaga taaaacccac atagtctttc gtagcaaccc
     8521 gggagtgaaa ccaatcaaat gaaaagaaga agccccaaag aaaggaagac agaaaaaagt
     8581 taatccgcag cttgttttag ggtgtggtaa aggtgaatga atagattgga cacatagaat
     8641 tgagaagatt acgccgcggg acggtacaca cgttcgcatt ggttgggcgt taagtacccg
     8701 atggcagaat gaatttgttt gccattatag aagcaggtaa tatacacgaa tatgctcttc
     8761 ttggcttgta cacgcgttat cgtagtaatt gtctttgcgg ctcatgctgc ttttcatccc
     8821 gtatttctgc aatcgtgctt ggtattccag gaaagcatac tggctaccac gatctgaaaa
     8881 gtggagaact tcgccgcgcg gtccagcacg ttttcatgta cgggtaagtt aggcttagag
     8941 ttcgtagttg ctttatactt cttgatggtt cgcgatttca agcaaagccc agttctttca
     9001 tgatgcgtgc aacggttttt cccgtcacat aaacgccttg ctgctctagc gcttccttta
     9061 tttttcggct accgtaaagg cgacacgaat ccaaaaagat tcggcgtatg cgttgctcga
     9121 gctccttccg ttttttctta cgcagggttt ccttgccttg ttctttaccc cttcataata
     9181 attgcttcgt gaaaccttaa atacatacac atcttcacga cacggagcta gaagtggtga
     9241 ttgtggatga aagaaaagat tagcgctggt cttttgcgaa gtagtgctaa gacttcgttt
     9301 tcctcctgca gttcacggat ctgcttctgc agaccacgca tagcctgatc tgcgggcgac
     9361 aaattcccgc tgcctgggaa agcctgtttt ccatgctgta catattcagc tttccagcga
     9421 tataacgtgt tcgtgctgat gccaagctcg cgggctacct gcgccaccga cttactctct
     9481 tcatcatctg tacggtttgg attttaaatt ctttgtcgta gttcttagtc atatcgctca
     9541 cctcgaatgc tgattttttt attttcgcat tctcggttct ccatgtccac tttctactct
     9601 agtagcattt aaccaatgca ccgtagtttg gatgtgagca gtgtggtgat gcggtacgac
     9661 tagtgacttt accgttgatg agattgactt gctcatcaat tcagcatagc cgatttagaa
     9721 taataatact cataatttaa catggagatt actttgccct gttcgtgggg aagaggtgaa
     9781 tattcttcat ttttggtaat aaacattttt tatatatttt ccattttatt atagtcatac
     9841 tgatcatcct tctatttgat tcaacgctgt tacgtgcttt caaaatttag gattataaaa
     9901 gatttcgggt atgtgtcgaa tgtaaagagg tctgaaagta tttaggctct aaaactactc
     9961 cctaaatctt ttttttagtc cactataatt aggaggaaac atgacgaaag aacccaatat
    10021 ttatcgtgca ctcgattttt ttatgattcg tacgcctgtt ttgccattca atttgtttat
    10081 acagtgtttt ccttccgatt ggaaagacca agaagagctt aagcgttatt cgctaaataa
    10141 acttgtcgaa ttatccaatg acccgatcat tcgcgaagcg attgcggtag cgagcccgag
    10201 cttgcttgag tcactttctc atcttggtaa tgaccagaat gcacgaaaga aagcgcaggc
    10261 tatcaaaggt ttcatgcgct atctgctccg catgatgacg cgtcccacac catttggcct
    10321 gttttccggt gtgacttacg ggcaattcgc cgaacagtcg cagatgaaca tagaaggcat
    10381 cgctacgtat cgcaaacgcg tgcgaccaga tatggaatgg ttgttaaaga ttgttgataa
    10441 gatcgagaaa caacgtgaag ttgtggttca gtttcgtatt cagcgcaact ctcttatcta
    10501 ccgtcaaggc gaacgagcaa agattcctta cgtagcgaga tatggcgatc tcggcgtcgg
    10561 agaaagtgat agcgtatccg tacgagcctc tgcagtattc gatctagtga tggaagctag
    10621 tatgaatcca attccgtacc tagaactcgt atcccggatt aagagtgctt tcatggaggc
    10681 agaattagat acgattcatc attacatttg gcagcttttt gaacaagaat tcttaatttc
    10741 ggaattgcga cctccgacga cgagtataga gcccttcgat catatcttgt ctgtgttgga
    10801 tcgggtagag ggtatagatg aatggaaggt tgctctcaat gaaattcgtc ggaatattcg
    10861 ctcttataat agccgatcaa ttgggcaggg cgaggagcaa ctacttcagt tgcgacagat
    10921 gatgaatgct ttggcggagg tgaagacgac ggtacaggtt gacttgtcct tggaagaccg
    10981 ttccgtgacc ttgccctctc aggttcgtga ggatgttgag aaagttgcac atttgtttag
    11041 tcgaatttct acgcgtaagt accgacacct ggaggaatac tgcaatgaat tcctagagaa
    11101 atacggtccg tatcgagaga taccaattct ggagttgctg gatgaggaga ttgggttagg
    11161 ggcaccggcc acctatcaaa atccgagcag cgttcatagg cagttgaaga atccgagtgt
    11221 gccattcagt acgaagtgtg aacaattact cttcaaatgg ttcgtctcgt gtatgcatca
    11281 gggtgaacaa gagattgttc tcacgaacga aaggattcaa cagatcttgg aggatgaatc
    11341 tgataaaacc accagtgagt taattcctac tccgtcaatg gaactctact ttttaatggt
    11401 tgtgcaggat caggaagcgc tcaatcgcgg agagtacacg ttagtacttg gaccgaatcc
    11461 tggatcgagt ggcgcgggga aaacgttcgg acgatttatt gatttaatgg gtgtctcgtt
    11521 taaaaacatg ttcaatgaga ttcatgagga agagcaacgc ctatcaccag gtaaactact
    11581 tgcagagatt tcgtacttac ccagtgcagc cagatcgacg aatgtcgttc tcacggaaaa
    11641 ttttcgcact tatgaaatcg gaattggcac gaatcacact gtaccagagg atcaacagat
    11701 tcatgtgtcc gatctgatgg ttggggtgcg agacgataag ttttatttga agtcacgcaa
    11761 gcacaattgc gaagtgatcc cgacagcggg gcatatgctg aactaccagg gtgcaccgaa
    11821 tgtgtaccgg tttttggtgg aagttagtca ggaaggatat cgacaatggt cgacattaga
    11881 atggggagta atggatcaat ccccctttac tccgcgttta aggtatggga acatcgtgtt
    11941 aagtccagcg acatggcgta tacaattgag tgacaagaca tctgagcgcg agagcgagga
    12001 gaaattggcg cttctggtta gggaattcag tatacagtgg aaagtacctc ggtatgtgta
    12061 tatgacccaa ttcgataatc gtatcttgtt cgatatggag cattctctgc atgtggagga
    12121 gatctgcaaa gacttgaaat caaatggtca agtgacgctg atcgagcata tagggggatt
    12181 cgaggatatg ccgatccagc ggagcgatgg gcgcctgacg gcggaatttg tcttcccact
    12241 cgttagacgc acggaagaga tggatctgac ccaagcggaa gtggcggtaa gtaaggagac
    12301 agaaatctct cgcctgactg ttgttgatgc atcgcagcgt gtgcagttgc cgggtggatc
    12361 gtggttctat gccaagttct atgggataga cagtcgccaa gatgaattca ttggtcgtca
    12421 gtggggagat tttgttcaga aatgccgtga ggcaggtgta attgaacaag cgtatttcat
    12481 tcgttactcc gatccaactc gtcatattcg ggtacggttc aacatgccaa gcggtaatga
    12541 catatcttcg ttcatcccaa tcttccatga atggacgact atgttacttc aagatggaat
    12601 gataaataag gttgttgtgg atacgtatga accagagatc gaacgatatg gtggacctga
    12661 gcttatgcta ttagcggaac gtatgtttgc ttgtgacagc gatgtcacag cgaatttggt
    12721 tcggctgctt cgatttaagc agatacagct aagtcaggag gtcgtggcgg tgtgtagtgt
    12781 gatacaatac atgactcagt ttggttacaa cgagcagaag gtttacgagc tcctcaatga
    12841 gcgcttcgat gtaaaagaat atctggatga cttccgtaat gaacggcgtt tattcctgca
    12901 gttgttaggg agggattcat ccgaattagt atcattgcat caagaaggta agctgattca
    12961 tcagattggt cagcacaggg aagaggctgt caagtgttat cagcaagcac ttcttgagca
    13021 tgagcggcag ggcactctta tgaacaacaa agacgatatc ctattcagtg tgattcatat
    13081 gtacttaaac cgcttgattg ggattgatcg agataaagaa cgtaaggtaa tgattatggc
    13141 tcgtcatgcc cttaatagct tgttgcaata ttggaggaag agccaatgaa ctttatttgg
    13201 aagggatgtc agcatgaatt agcttcactc tggaagacgg ttcgacacgg gctgcaactc
    13261 ttccaattga tttttcacat gaataaacag tatatgattc caagtatgat actacacatc
    13321 attcaaggcg ctgtgcctgt gatgacatta atggttacac agaatttgtt gaatagtgtt
    13381 tccgttggat ggaaagaagg ggaatattgg gtactttctc aatttgtttg gttcatcgtc
    13441 atctatgttt tgaagaattt catcgacgtc gctcaaagct atgtggaggg taatcttcag
    13501 gcggtcattt ccaattcgat gaatgtcatg atctgcgaga aatcaaccac gttgggattg
    13561 gctgattttg agaatgcttc gattaatgac caattaaaaa gggtttcaca agaagccact
    13621 tatcgcccct atcaattgta tagccagatg gctggcatag cttctggact cattacactt
    13681 atttcatctg ctatcttact tgttctgtgg aaatggtggg tggtgctcgt gattctcatg
    13741 atatcaacgg tttctatcta ttcgattttc aaaatcaatc gagaacagtt ccaaatctac
    13801 ttggatcgca ctccgcagaa tcgagaatcg tggtacatga cgtatctatt aacaaacgat
    13861 agcacattta aggaagtgaa aatattccaa ttgggttctt acttgttaaa ccgataccgc
    13921 gatttgttgc acggcttctt ccttgtggat cgtcgtatat tgttgaagcg aattcgagtt
    13981 acttttctgt acgatatgct agaaatggtg gctttgttct ggttaattgg gcttgtaatt
    14041 cacgagacat ttataggagc gatgatgatc gggagtttgt atgggtatat ccaagcgatt
    14101 atgctcacgc agaaccagac gaagggggtt attcaggggc ttgtccagtt ctcacagaac
    14161 aatctttaca tggagcaatt gctcttgttc ttgcaattgc ccacgtcaga tcctgttcat
    14221 cgacagaaac agtttcccaa tgcaacagaa ctatcgtgtg acgcaaatgc aagtatccag
    14281 attacacaga tttcgttcga tcaggtatct ttcgcttatc caggacaaga ttcggatacg
    14341 attcgagaag tggatgtgac attcaagaag gggcagactg tggctattgt agggaagaat
    14401 ggttcgggta agtccacact cgtgaagctg ttaatgcaat tgtacacgga ttatcgtggt
    14461 accatccaag tcaatggccg taatgttctc gactacgatc tgcaacaagt ccaagaacgc
    14521 atgggggttg tgtttcaaga ttttgttcac tatgaaatgt cggctcgcca taatattggc
    14581 ttcggctcat tggctgagct cgaacaagat gagcgattga tggatgcagc caaagttgca
    14641 gctattgacc aaatgattgc gaatttgcca agcggtctcg atacacaact tggcaaatgg
    14701 ttcgatgaag gacatcaact ttcgggggga cagtggcaac gtattgcaat tgcaagagcc
    14761 attctgcgaa gtgcggatgt atatgttcta gacgagccga gctcgttctt ggatccattg
    14821 gctgaacggg acttactgca attgttcata catttaatga gagatacgat agggattttc
    14881 attacacatc gtatctcgtc tgcgcgtcta gcggatcaga ttttagtcat ggaggacggc
    14941 cggatcattg agcagggatc gcatgctgaa ttgatgcgtt taggtggggt atatgcgcag
    15001 atgtatcaag tgcaagcaag ttcatttgca gaagaagttg gggtgaatta gaaggagatg
    15061 attgagggtg aaagcggcaa gtgcggtatc aacacaatgg atccccttaa aaggggaagt
    15121 tagaaagcaa gtagcacaag tgttgcaggc gattgtgcag cgttataagg atcctgatca
    15181 ggtacgtgcc cagatgaagc aagttcctgg gcaagtgatt gaagggaaac aggtagcacg
    15241 atggtcagac acaagcttct cgggtggatt tacaggtatt tgtgtattaa tgggacaact
    15301 ggatcagtta tatcctgatg aaggttggga tatggtaggg catagttacc tgcaaaagat
    15361 tcaacaggta atcgaacagc aaggtattca tactctatct ttatacagtg ggttagcggg
    15421 tattttgata ggcgtccgtg ctctgtcacg aaagaatacg cgctaccaag gcatgctaga
    15481 tacactggct agttggttcg aggaagccgt gttaaattat gtagagatat gcaaaaacca
    15541 gtgggaagaa gggcaattgc gtattagtca gtacgataca atcgaaggtt tgacaggaat
    15601 tggacgagtt gtgttggctt tctcagatcg accgcagatg aagatcatct ggcaacggat
    15661 tgttgaagta ttccatatct tctgtgggga aaaagattat ctaggacatc ggatccctgc
    15721 ttggcatatc ccgtctgcga atcagttcct cgaacatgaa aaggtgcagt atccaaatgg
    15781 gaattttaac gtaggtctat cccatggtat ctcaggaccg ctggcttttc tgagtctatc
    15841 gcaattgcag ggcatgacaa cagaagcgat gcgtgcagat ctacggcggc tcaccgagtg
    15901 gacatgtcga tggcgagtga gcggtgaagc gggaacgttc tggccggggc gagtcgctgt
    15961 tgaagaggta cttcagggtg aattgcatcc gagcagtatc cgagacccgt gggactcctg
    16021 gtgctatggg gtgcctggga ttgcacgatc catctggcta gctgggcaag cgatggataa
    16081 tcaggaatgg agcgcaattg gattgcaggc gtatgtagag atagagaatc gcatccagac
    16141 tatgggtgga ctcaccgcct ctaccttgtg ccacggtgta gggggactgc ttcatatgat
    16201 tcaacgtatg tattcggata cgggtcatgt gacgcttggc gtgatgcgtg atgaactagt
    16261 tgtggctgtg ctggataagt atgcggcaga gtcgaagttt ggttattatg atgaacattt
    16321 tgtgaatggc aagtatgagc aagtggatga agcgggcttt ttgacgggtg ccgcgggcgt
    16381 ggcacttgtg ctagcttctt tgctttacga ggaaagcccg gattgggata tggctttgtt
    16441 gatacgatag gttaacacca tactaccgaa caccgccggg actgatgaca gaagggtctg
    16501 aggaaaaaat cttcagaccc tttatccatg ggtatttcac aaacgatgtg attcttcatt
    16561 ggtctggcta gagcttcaag cattcgtaga atgttgaggg acaacgtcga aaagaggcag
    16621 tatgagcagt cagctcgttc ccccgtcgtt tttcaaaccg gggaaagtca cttcggtaaa
    16681 tatcttctgc ttagcttcat ccgccgcggc caagttatat gtgggtttgg tgtgattgag
    16741 tccaagtcgg tgcaccattt tagaaatacc acgcagagaa tagggatgac caaactcccg
    16801 cttgatgtat tcgccaataa gagatagagc ccaacaatat ttttttagaa atccgacttc
    16861 gtgtggaacc gcgtagtcac ttgtagttcg actacttatt tgtagaccgt tcgttccgtt
    16921 ctgtcgatga tttctgagat ctcttgtgca ttcttttctt tcaaatgctg ataaatgtct
    16981 tgataatgct cgaacatacg cctatctttc tcctttttca tcaaagcttc aattcaataa
    17041 atccttgtgt ctgttccata ttttcaccgt cgcttttatg accttatagt tatttcgggt
    17101 tattcgtagt ttagcttggg tcacgtaaat ctataaaaat cggacaaggg aatcgtgttc
    17161 ggtgagatga gcgggttgtg gctccaaact gatcgcggtt ctcttttgtt ttaaatctcg
    17221 actttcttca gcttaagtct gccagcgaac aaataaatcg tcgtcttcag gtttttgagc
    17281 gacctgtagc cgtgtgcccg tcgtttggca cattgaataa gaccgttaat gacctccata
    17341 ataccgtttg ttattttcga tgtaaaccac tttaagatcc ctgttgcatg ctgacgaatc
    17401 gttttcgcag atttcaccat atcagggatt tgattatgtg tcgcccaaaa ataccagcta
    17461 tccaagaaca cttccgcttt ctcaggcgtt tcctgcttcc acaacttcga aaatgtgagc
    17521 ttcaagtgat acgcttttgc cgttttcaga tcttcatcct tgagactctt tgcttgtttt
    17581 atagtttgaa gacaaaccct agtctgatga gcgaagaaat caacgccgta aataccacga
    17641 ggtaatctgc gtaatggggt tttggtatct taaatagaat gcctaacaag aagaagagta
    17701 aaaggagcgg aacggcctgc gtctaccgtc tctgcttttt tttcgtatta ttaggtcagc
    17761 cagaaacttc tggtcggcct ttttttggct ccagagcatg gagattacag ataatttaat
    17821 tgaactgctc attcagattg ttcactgtat cggcgttcgg gctgaacgac ctgcggaaag
    17881 tgggcaataa gtacggtatc ttatttaacc tagcacaatc tgccgtcaat aatccggatg
    17941 gaattgtacg ggatgtgatc tttccaatcg tcaacgagca aacattgagg gatctagtaa
    18001 aagagagcaa gcatacaggc ccggcttatc gcgagaaagt tcatacgatt atccgtgctt
    18061 cctatgggag ccattgggta tcctggactt ccgctccaat aacgaggttc atcagccagt
    18121 aatcctcgcg ctggaactgg tcaaaaggta ttcagataca ggccaacact atttacccct
    18181 gttggaagat gtcccgattg atggagtcat acgtaacgtt aatagagaaa tcattgtaga
    18241 gaaagacgag aaagggcaag agcgcataaa tcgtatgaat tatgagatca gtgttttgca
    18301 agcattaaga gataagcttc gctgtaagga aatatgggcg gtcggtgcga accgatatcg
    18361 gaacccggat gatgacttat ctaccgattt tgaggaacga cgtgaagaaa actacaaggc
    18421 cctaaagcaa tctttggacg cccatgcctt tattgaaatg ctgaaagaag ctatgaaaga
    18481 tggattggag aaaatggatc gcgggctatc caaaaacgaa aaagttcgaa ttacagagaa
    18541 agggaatggt tggatcagtt tatcaccttt agaaccacaa acagaacccg ttaatttatc
    18601 ccgtgtaaag tcagagttac tacgacctga tacttcccca attttgaaaa caaaaaaatc
    18661 cttttaattt gtaatctccc ttatcacatt cttcgccaaa cgtactttct caggactcga
    18721 ttttttgagc atcgtaataa tttgtataac atcttcatca gactccataa ttttagggtc
    18781 ctcgcttaca tatgaaaata actgaattaa gtttacgtct agtgcttttg cgatcttagc
    18841 tacatttatt aaagaaacat tcttttctcc acgttcgatc tgtccaatgt atgtaaaatg
    18901 aaatccacct ttttctccaa gagcttcttg tgagaggcct ttttctttgc gtaacactct
    18961 tattctagcc ccaactagct ttaatacttc tttgtcctgc atttgtctac accccttcat
    19021 actaaaaagt gtagacaaga ttttcttggg taaacatgag attaagaatc gtatatttag
    19081 cattcattat atctataagt attattttag gatataataa gactaatatt gaaattctct
    19141 ggaggaatag atatgaaaga agctccttct acctttattc caagtcccac ccaaccatcc
    19201 agaccctcac tacacctaca taaatcaata accgatttcc acactctatc tcaataccac
    19261 atgaaactag cccaaatcct gtacaagcac aatcaagtcc aatgctgcat tatcctatgt
    19321 gactgggcgt taacctccat gttaaaagct atatatatga aagaaaacaa cagccttttc
    19381 cctcccggat tcctgtctat gactgacctg ctgcacttat tacataccga aaccaacccg
    19441 ggattggatg ttgtcgtatt tataggcacc actcaatttc tttcatctca gctagaaagc
    19501 tctctccttc aaaaaatgaa gtacaaggat gtgagcaggt tactgcgaag aacggacgac
    19561 attctctgcc agttgtcatc cagagtcatt agcgatctat ctcaaacgta tcagtccatt
    19621 ttctgagtag cccttccatg gcaaataaac ttgccgattc gccctgtcgt tatccgcgtt
    19681 tcttcatacg ataagagtaa gctttaacgc aaggagggat tcagacatgg gtgaagtagg
    19741 ttacggtgga gcatggacat ccacaggagc gattttggta ttgtttattt tgttggtaat
    19801 tattactaag tcttttctga tctaacagca ggttagcatc gcttaaatcc acaaatccgc
    19861 cttctttctc gacatcgtga gggagggctt ttttatgcag aatgggtgtt agcccaacat
    19921 gttgtctggt cctgcaagca ttgctatact ttacatacag ggagattttc cctcaagtat
    19981 attgcaatat ggatagcgta agacgtggaa aaacagaaat tcgctgacca aatcaggagg
    20041 atcgcatgat gaatacggca agcagtccat ttcaatttac aacagatacg gcgactcttt
    20101 gcttatttga tacgcaagct cttaagcacc gcttggacga tgatccggat tggtggtcca
    20161 tcgaagagga cgagctgggc gagttgaaca aaggaaatgt agcttttttg aatcttggag
    20221 ccgatgggac ctatgaggtt gggatgacag atcatatcga caagcctgct gtacggctgt
    20281 ttttgaaggt tccctcaggc aacctattta ttggagcagg ggaggaagcc acaggtggtg
    20341 gactggagcc tgaatgtgta tggggaggga cgttcctttc tgtgcaaccg ggactttatg
    20401 aatgcttggc gagcaaagaa ggcaaccgta tttatctttc tttaaaaaaa ggaagcgaag
    20461 gcagcaatag ctttacaggt ctgattcgat tgtaggttgc aggctcaacc cgtaacggcc
    20521 catacaagcc acctgaaccg gtggaagcag gaacaactga aaccggggaa aatgaaaaaa
    20581 gggttatccc cacggcttac acatccgtga agatagccct ttatctgtct attgatactt
    20641 tacaataatg gcattgctga tttggcggcc gggtgtggtg aggtaggagc cgttgtaata
    20701 cagcccgctg gaagcaccgc cgtccagatt catggcctga taagcgccgg cctgcttcat
    20761 catttgggcg agctgcggta tagtcgctcc acttgtggtc aggaggatca gcttatgatc
    20821 ccgactcatt ccgagtgcgc tgcgggcgcc gccgcctgtt aatattttag ggtccttgaa
    20881 gccttcggct ttgacattta gggaaacctg tccgttcgtg accagacgag gcccagcttg
    20941 cagggcacct tcgatgttac cttggcttaa tctttgttca aaggcagaac ccgacattag
    21001 ctcggataaa tggttagcat cgtaggtgaa gaccgtccgt tggtcgccgg agcttttttt
    21061 caatatcttt ccgtgactga ctaggtagcc gtaaggcgtt ttgtaggagc ttttggtata
    21121 ggcgtcaaag aatgtgccat ttatggctac aaccgcttga ttgcgtttgg cgagactgct
    21181 caagtcttcc actttgccga tagtattgcc tgccagagcc acatccaggc ttaccttggg
    21241 atggagcata gagatggtga ccaccttagc ggaaaaggta cgagatccga ccttgaagct
    21301 tttatgagcc gtcgtaatgg gtgtagtatt tccggggagc ttaccggtaa gtaccggaag
    21361 cgtgacggac gttgtaccct gcttaatgcg tacagctgag gtttcctttt gccatgagac
    21421 ttgcaggttt agatattggc tgatgaactg caagggtaca taggtcgaac cattatcgtt
    21481 aaaaggagca ttttgcaaac ggaccgtttg atcgttcact ttggcagtag attttccggt
    21541 aaatagggta atccgagtat tgccttgcgc aatttctatt tttttgtccg ctgccgtcat
    21601 gttgagtgtg atcccttcat agctgttcag gagacgaagc gggatgaacg agtggttact
    21661 ctggtccaca tagaccagca taggtgctgg ggcagcagcg tagatcgggg atacaagtaa
    21721 tagcaaggac aggatgacaa gtgcggtgat tcttttcatg aatagatcaa tctccttatg
    21781 tagtcttgac actttacgag gtgcttgtaa ttatatcggg ttttataagt tataaatgta
    21841 tgttatgcga attttgagtg tttagctgat ataggaagcg ggaggttgga gatgagcagg
    21901 tatgagacaa gacttgagga ttaccgtcgc agagagcgcc cgtcctatcg tgtatttgaa
    21961 ggattacagg aattggtgcg tagcgtgggg caactgcata ataactggtt atatgtgaat
    22021 gtggatcaat gggatcagga ccctgttcac acaccgattt attattggga tgagcattgg
    22081 ctggaggaat gtgcagagaa gggtacagcc ataaccaacg aacaggacga gtatattccc
    22141 gagtgtgtgt cggatcgtca ggttcaaacc tggtttgagc tggcgacctt cgaaagtatt
    22201 gtggaagtcc ttaaggctgc cggacagcca gtgacgcttc agatggtgat tatggcggta
    22261 aaatactatg acaagcgaga tgcctatctg gactatgaag aggtgaaggc agtaacagac
    22321 ctgtggtctg tgctgacaaa ggtgagaaac caccttacat aatgaacaaa gcctgtagaa
    22381 caaacggggc atacatacac tggatggggg aagcaaatga gttggttgaa tcatgaaatg
    22441 gcagcaaagt ggcgacagga agggaaaagg tatgccgcag atgtgaatga atttgtcaga
    22501 gtcggcatgg aaagtgaatg gcagcaggag caatcagagc caaagcggga cgaacgcccc
    22561 aagatggcca aagatatttt tcgtatgatt caggaggcaa atcaggctgg tgaaatggag
    22621 cagttacgtc gagagattcc agccgcgtct tggccgctta caccagcgtt cgaggaagct
    22681 ttgcaagccg ttaggccgat agcttttgtg aatggaggca atgaaatcat tgtacatgcg
    22741 ggcaatcctc gggaacgtgg gacgatctat gtgacgggaa aagatagaat cttgcaaatc
    22801 cccggactgc atcgagtagg ctgttcgccg gacgggactt attttgcgtt ggtggatgga
    22861 caggggattc gtattgttcg tcaaccggac cgaaatctgc aaggagaaga gacagcacat
    22921 tttcagtgga aggatataca aggacgctta aaagcatcca ttcctgatct ggagtgcttg
    22981 ggagatgagg atcatcctga ggatatatta gatgaagtga ttccgtttgg cgatggacag
    23041 cgacttctgc tggtctgcgg ttacggcgtt tatttgctgg ctggtgatca ggtggatttg
    23101 attcatccca aggcgtctga acggagagaa ctaaagctgg aagacacgat tgtggatatg
    23161 gcccatggag ctgtgtcgag ggatggacgc tggatcgctt acggcagcca gatgagtgag
    23221 catatgctta tggatctgtc cgataagacg gtgcatacat tggagccaag ttctagttat
    23281 ccgcattatg ctctgttttc caaagatgat ctggatgtct ggtataatgc ctgtcatttc
    23341 tacaacggtg ctaccattca agtgtcgatt gctgagatgg agcagggtct tgctcagaat
    23401 aaggaagaat ggccgatgat gaatgaagaa atgcgagtat acgccgcaac agcgctgaca
    23461 caaggatcta ttttgggtga tgcctacggt tatctccgtc tgattgacag ggagggtcgt
    23521 gaactttggc gctattttgt cggcagtacg atatccgggc tggcagtttc acctgatgaa
    23581 ggtatgttag cggttggaac gtatggcggt atgcttcatt tgattgattt gcagagcggc
    23641 acgaaggacg aatatagcat tggcaccgcg ccatttcacg agacagcgcg ttgggtgatc
    23701 tggcggaact acgagccatt gcgctggtaa tactaatatt ccgcaaatgg tgataaaagc
    23761 aagttctgat aagctgaact taaaaagtgt agtagcacat gattacaaag ctattttcag
    23821 atagagggca tttggcatta acccatgatg caaaatgtga atagagagga aagaggtgtg
    23881 aggacatgga caagaaagcg gatattcgta cttccatgaa agaactattt gctcagatgg
    23941 atgaagcctt ttttatggat gtggaagaaa atgttccaat tgaaatgcgt gatgggaatg
    24001 tcgacgagga gggatggatc aagtggaagc ctctcccttc gcagattact gaacaggaag
    24061 ttcgggagat ggaggaaaaa taccattttg agctaccgcc cctgctgagg agctttatca
    24121 tgtcctacca ttatgtatct ttacaattcg ataatgaatc gattccggga gtatactgga
    24181 gcgattgtac gtttgttgag tttccacgac tgcctgtagg tcagggctta aaggcatttt
    24241 atgatttgct cgatcaatgg tcacctctgc tgtcagcagg ctacattccc tttgcaatag
    24301 cagaggacga tcagggtccc gtttgtttaa atgcaggcag cagacataag gacggcgatt
    24361 atcctattgt ttggttcttt catgaggacc tacagcattt ggatgaggat gagctacgaa
    24421 tcagaagtaa tctgcttccc catgtacagg ggctgtttcc atcttctgtc gaaatgttta
    24481 acgtgatgtt taagcacatt agacactagc gatttcctaa aatgtaattt tactgctcag
    24541 gcaaccgaga tattgacata aaaaatgagg aatgttataa aaaaggtagg ctagcactcg
    24601 aatgatggga gtgctaacaa agttgaatcg tttgcatagc tcatatctgc tggccttaca
    24661 taggttcata tctgaaagga gatatccgaa tggagaaaaa acagtttcag gctgagtcca
    24721 agcgtctgct agaaatgatg attaactcga tttacacgca aaaagaaatt ttcctaagag
    24781 agctgatctc caatgcaagt gatgcgattg acaaaattta ttacaaagca ttgacggatg
    24841 atcaactggt ctttgacaaa gaaaattatt atatcaaagt aactgccgat aaggataaca
    24901 gaacgctaac cctgcgtgat accgggattg gtatgaccaa ggaagaacta gaaaataacc
    24961 tgggtgttat tgctaaaagc ggctcactgg cattcaaaaa tgaaaatgaa tccaaggatg
    25021 gtcatgacat cattggtcaa ttcggcgtcg gcttctattc agcttttatg gtagctgatg
    25081 tggttacagt gactaccaag gctttgggaa gtgatactgc ttataaatgg gaatccacag
    25141 gtgcagacgg gtataccatt gaagcagctg agaaggacga ggttggaacc gagatagttc
    25201 tgaaaatcaa agcaaacacc gaagatgagt cctacgacga atatttggac gagtatcgtt
    25261 taaaagcact gattaaaaaa tactccgact ttatccgcta tccgattaaa atggatatta
    25321 caggcaagcg tctgaaagag ggaagcgaca acgagttcga ggattacgaa gaagaacagc
    25381 ttatcaacag catggttcct atctggagaa aaaacaaaag cgagttgacc gacgaggatt
    25441 atcaaaattt ctatgcggaa aaacgctatg gctacgacaa gccgctccag catatccatg
    25501 tcagcgcgga tggcgcggta gtgtaccaag ctattctgtt tattcctgaa aatatcccgt
    25561 ttgatttcta ctccaaggaa tatgaaaaag ggctggagtt atatgccaac ggtgtgctga
    25621 ttatggaaaa atctcctgac ctgctgccgg attattttag ctttgtcaaa ggtatggttg
    25681 actccgaaag cctatcactc aacatttcca gagaaatgtt gcagcatgac cgtcagttga
    25741 agctgattgc caaaaatatc gaaagcaaaa tcaaaggcca attgctgacc ttgctcaaaa
    25801 atgaccggga gaaatatgat caattctaca aatcatttgg cagacaattg aaatttggtg
    25861 tctataacga ttacggcaga cataaagaaa ctctccagga tctgctcatg ttctactctt
    25921 ctacagagaa aaagcaggtt actttggacg aatacgtatc acgtatgcca gaggatcaga
    25981 agtatattta ttatgcttcc ggcgagtcca acgagcgtat tgaaaaactg ccgcaaaccg
    26041 aaatggtggc cgataaaggc tacgaaattc tgtacttcac cgatgatatt gatgagttcg
    26101 ctattaaaat gctcttaagc tacaaagaga aagaattcaa atctgtgtct agcggcgatc
    26161 tgggaattga gcctgacgaa aacgagaaag aaacagaagc agaacaaaac gacaacaaag
    26221 agctgttcga gtacatgaag ggcttgttgg aaggcaaggt atccagtgtt aaagcctcca
    26281 agcgcttgaa gacacatccg gtatgtctgt ccgcagacgg tgaagtgacg attgagatgg
    26341 agaaaatctt aaacgccatg cctaataacg ctgatgtcaa agcgaataaa gtgctggaaa
    26401 tcaacgtaaa ccatgcggtg ttcaactctt tgaaagaagc ttttgccgag
//
