LOCUS       NZ_CP073683            27004 bp    DNA     circular CON 15-MAY-2024
DEFINITION  Paenibacillus sp. S25 chromosome, complete genome.
ACCESSION   NZ_CP073683
VERSION     NZ_CP073683.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus sp. S25
  ORGANISM  Paenibacillus sp. S25
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5958851)
  AUTHORS   Li,T., Mann,R., Kaur,J., Spangenberg,G. and Sawbridge,T.
  TITLE     Transcriptomics differentiate two novel bioactive strains of
            Paenibacillus sp. isolated from the perennial ryegrass seed
            microbiome
  JOURNAL   Sci Rep 11 (1), 15545 (2021)
   PUBMED   34330961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5958851)
  AUTHORS   Li,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2021) Agriculture Victoria Research, AgriBio, 5
            Ring Road, Bundoora, VIC 3083, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 31-MAR-2020
            Assembly Method                   :: Unicycler v. 0.4.8
            Assembly Name                     :: AVR_PaeniS25_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019454085.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 03:29:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,267
            CDSs (total)                      :: 5,136
            Genes (coding)                    :: 5,079
            CDSs (with protein)               :: 5,079
            Genes (RNA)                       :: 131
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 91
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 21 of 57
            Pseudo Genes (incomplete)         :: 38 of 57
            Pseudo Genes (internal stop)      :: 14 of 57
            Pseudo Genes (multiple problems)  :: 14 of 57
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:16:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1716609
            Orig. end                         :: 1743613
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073683.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from AgriBio, 5 Ring Road,
            Bundoora, Victoria 3083, Australia.
            Annotated using prokka 1.14.6 from
            https://github.com/tseemann/prokka.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27004
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27004
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27004
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17004]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17004
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            508..1689
                     /locus_tag="KAI37_RS07445"
                     /old_locus_tag="KAI37_01509"
     CDS             508..1689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="KAI37_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01509"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_069080726.1"
                     /transl_table=11
                     /translation="MIKKNIDSYGQKNGSPRREDSRTRVFRQKATGVLMAGLIAGGLLS
                     GCGMKSAGETNPASGMKPGQQLTVIDTDAAQQQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERKTQLWIHNVETDKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTPIGKLDMTNEVSWSDENDLITGTPDGKIQLIGLDGKAKELSFQDPNRSEL
                     MSHVEKVGNAIFYTGSDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSPDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAYSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
     gene            complement(1676..2707)
                     /locus_tag="KAI37_RS07450"
                     /old_locus_tag="KAI37_01510"
     CDS             complement(1676..2707)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014649242.1"
                     /locus_tag="KAI37_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01510"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_071640085.1"
                     /transl_table=11
                     /translation="MNTHPSFREVRESDQQVFPIAWYAVGWSKELKNKPLKKRLLGKDI
                     VLYRDDHRQVHAIHAYCPHRGADLSLGYCQNGHITCPYHAWSFDESGQCVDIPAHPGRA
                     IPEFAHTYAYPATEKAGLLWVYPQAVGSNSEINSGLGTSTSPPPLEIFPELEDPSLILS
                     PYDSMWKAHLTRVVESVLDVAHLPIVHNKTIGKKSSTDIHIEFEADDNHIRVKNGKGLL
                     QYTFPQQWILTPAKEGRSKFINFVTFTPIEQELTAIYGLAGRNFARFVPGMSHIFSRYS
                     GKVLEEDRAVVESQHPRPIPEALRMEAHVPADGPQVRFRNRWYDFLVNDEPRVRLGPET
                     TSS"
     gene            complement(2922..4364)
                     /locus_tag="KAI37_RS07455"
                     /old_locus_tag="KAI37_01511"
     CDS             complement(2922..4364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="KAI37_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01511"
                     /product="SpoVR family protein"
                     /protein_id="WP_071640086.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLDTVKQHDPAETEGIKVRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            complement(4361..5527)
                     /gene="yhbH"
                     /locus_tag="KAI37_RS07460"
                     /old_locus_tag="KAI37_01512"
     CDS             complement(4361..5527)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="KAI37_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01512"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_025723949.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKREGGTVG"
     gene            5692..6411
                     /locus_tag="KAI37_RS07465"
                     /old_locus_tag="KAI37_01513"
     CDS             5692..6411
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="KAI37_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01513"
                     /product="response regulator transcription factor"
                     /protein_id="WP_071640087.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESHMDVIVLDVMLPDSDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVSTVAMKPTLRTLDFGYFRLELESGVLYVEGKEVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYETIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMGEQE"
     gene            6408..7478
                     /locus_tag="KAI37_RS07470"
                     /old_locus_tag="KAI37_01514"
     CDS             6408..7478
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="KAI37_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01514"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_220030994.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTILYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVELEKRKQQWVAGVGHDLKTPLSYI
                     EGYAAMLTAQEYDWSEEERRSFSMSISEKVTEMKQLIQDLNASMQLKESPLPIQLEKED
                     IVEFLRSTVIDIANHPSAEQYEFSFTSMEAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMEVSKTNDKLHISIEDDGIGMNPNEYMQISHSQGHGIPIAKSFIEAHNGTLHILS
                     GSKAGTRMEISLPLNI"
     gene            7624..8547
                     /locus_tag="KAI37_RS07475"
                     /old_locus_tag="KAI37_01515"
     CDS             7624..8547
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="KAI37_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01515"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_029516536.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDVGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLAKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     gene            8544..9251
                     /locus_tag="KAI37_RS07480"
                     /old_locus_tag="KAI37_01516"
     CDS             8544..9251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="KAI37_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01516"
                     /product="ABC transporter permease"
                     /protein_id="WP_025723953.1"
                     /transl_table=11
                     /translation="MILRVIKSEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMVMPVPRSYIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            9266..10000
                     /locus_tag="KAI37_RS07485"
                     /old_locus_tag="KAI37_01517"
     CDS             9266..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="KAI37_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01517"
                     /product="ABC transporter permease"
                     /protein_id="WP_025723954.1"
                     /transl_table=11
                     /translation="MGSILRVETIKLQWIMVWILIILDAVINSLMGVLELNDLKQFFSP
                     SWLTLYTYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYIL
                     LILILGLDQLIFIAGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKI
                     RNFGASLGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTATYAPRVEPYSLGLI
                     VIFTFLAYLYGGRKMFVNRDWL"
     gene            complement(10001..11362)
                     /locus_tag="KAI37_RS07490"
                     /old_locus_tag="KAI37_01518"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="KAI37_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01518"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_220030995.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-56, bitscore:
                     189.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYAAVQSEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDPSYDWNTAIHSNMAQIQSSLSKNGLHDLS
                     LYSGWAGIASSVREASNHGKYYSNFLQQIHQWMMPLTEQWLQSNTEQLSLHEGMPMQAF
                     DTISGASGIGRYILMNSTDPICTPLVEPILQFLTDLTHPIHIHNRYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSAGIEVKGQYQAIETIAEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLQFDLERAREAWCYGTPGIACTLFLAGKALHNEELQKLAVKA
                     CVGAISHEIAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFFPLIQQLTNCLLDRFQM
                     DSPLGYLDPEPRSDGSLTWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            11560..11712
                     /locus_tag="KAI37_RS07495"
                     /old_locus_tag="KAI37_01519"
     CDS             11560..11712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="KAI37_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01519"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_071640090.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.2e-05, bitscore:
                     22.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKDEVASKGVQPASGIICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       11560..11631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKDEVASKGVQPA"
                     /locus_tag="KAI37_RS07495_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11632..11712
                     /prepeptide="core"
                     /locus_tag="KAI37_RS07495_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.40"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGIICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKDEVASKGVQPA"
                     /leader_location="[11559:11631](+)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            11789..13051
                     /locus_tag="KAI37_RS07500"
                     /old_locus_tag="KAI37_01520"
     CDS             11789..13051
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="KAI37_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01520"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_076293731.1"
                     /sec_met_domain="LANC_like (E-value: 3e-58, bitscore:
                     195.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDLKGRSVEISKYIAQKLIDLSYTEKIVNHTNNLSPSRGNPPW
                     NPGSLADGIPGVFALLSEWGYLEPDQNWAEHVHSQLRYLDANSLLLLPRISLYYGTTGV
                     AYGILLASNNRANYNKLISQLNKYIEVKWGDLPVIGTITEFSRQMDIINGLLGVGRYTL
                     EVAEDKTMCDLSRQLLDTITHFIPEYIHLSSREDSASIDLGLAHGITGILALLVTALQK
                     KIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQASSMNKREKKVGMREIEGWCHGT
                     FGIAWTLLRAGIECSNEEWKKIAEKAMESIFCLDDELLNALSPTFCHGLAGLLHMAHRF
                     SSLTDNIAALRFADQIALKLVNLYDEELPFGYQDLEGTTHVHNVGILQGATGIALSLLD
                     YGIGKEHPKYSGRWSELFLIS"
     gene            13101..13775
                     /locus_tag="KAI37_RS07505"
                     /old_locus_tag="KAI37_01521"
     CDS             13101..13775
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="KAI37_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01521"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_076293730.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLSTPENIQIMFYDSLYQAITEIDEQ
                     CIGVALNQDHITLEDLSYWHSIKEKFKVPFIFLSYHSDQQQLDLLKQLFSMASSKYGME
                     REQQAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRVW
                     GVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETTA
                     LH"
     gene            13903..17004
                     /locus_tag="KAI37_RS07510"
                     /old_locus_tag="KAI37_01522"
     CDS             13903..17004
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370171.1"
                     /locus_tag="KAI37_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01522"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_258383081.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-191, bitscore:
                     635.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.2e-15,
                     bitscore: 54.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-51, bitscore:
                     173.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSQLTLEEITRRLKLISQEAVVQEAISLASPSLMQFLHYLNDGH
                     ALDDKGELQKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGSYPKHLK
                     RARPDMEWIYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAEADDSAE
                     IFNSIRLTDVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSE
                     LRPPLMDHSPFHYIFEKIKKLDISDPWIHILHEIDALLLQYNQCTIGEGEKVYRKLCDK
                     MLDIISVKTPVQVDVKLDKEVTLPKHVLDEVSLGAEVMCKLYASPKTDELDEYLNRFLE
                     KYGVYQEVPIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSDAISNHEIE
                     LALTDEQLEQLMISDNYDTSPESMEIYYSIFADSPEKVDSGDYSLLLGASAGSNRAGKT
                     FGRFLDMLSEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNLMAYEIV
                     SGTTSSKDEDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLT
                     DITNKEIGTWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCESKEGEE
                     LFHVWRQQWNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLTECLGNP
                     FHTPVQGTAGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFITHTPSSIHRGIFPGG
                     EWLYLKLYGIKERETDLVGLSLGHLLKQPGFKDWSQKFYFLRYVDPEHHIRLRFQGEPD
                     KLWTAGLAQLNQWAAELREEGLITNMVIDTYHPEWERYGGQTLMELAEQVFDVDSQWVI
                     AYMKGIRSNAFNLDIEIVAVMNIIHYLSGFGLTIQEQVKWLEERIDCKPHMKAFRDVKK
                     TLITAVESNYEWIGQADTNTQVAFLALVEKRQTMIQKYAQAIILAKNNHELTNHPDDIL
                     GSIIHMHLNRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        14296..14580
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KAI37_RS07510_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-17"
                     /identifier="RREFam001.1"
                     /label="KAI37_RS07510"
                     /locus_tag="KAI37_RS07510"
                     /protein_end="226"
                     /protein_start="131"
                     /score="54.8"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPP"
     gene            17159..18892
                     /locus_tag="KAI37_RS07515"
                     /old_locus_tag="KAI37_01523"
     CDS             17159..18892
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="KAI37_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01523"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_258383054.1"
                     /transl_table=11
                     /translation="MILLTTRELINSVVAGASGGSFQPVFIAFGVLIGVNLLYDLINIG
                     ESFFRKMFQSRLSNQVNIRIIEKAQKMSLQSFEDADVQNMLQRAQGEADFRPFEIFTQI
                     LAIISSVVTLFSTGAILIAWRWWAFLFIFLIPCLSFYSFLRIGQREFNVHFQRAGRQRE
                     SWYLSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEGFYREDKVLAVRRSYTSLVFQIVN
                     QGACAFIIFMAIQATYVGQILVGNLVSLIQGITLTQSTSQSIVQGILSLCQNNLYIKQL
                     FDFLDMPEEAKIQKSVQQLPLSAIHSIEFRNVSFRYPNTEENAISNVSFKLHQGEKLAI
                     VGKNGSGKSTIVKLMTHLYSDFEGEILINGHSIHELDKDSFRAKIGVVFQDFVHYEMAV
                     RDNIGFGNVASRENDEAIWTAIDKAGITDLIVGLPDKINSLLGKWFEDGQQLSGGQWQR
                     IAIARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFDQLIHEKIGVFISHRLSSARMADI
                     IILMEEGRIVEAGSHERLMDIDGVYAEMFRLQASSYLSQRERGFEEENLSPSLVRTTGG
                     S"
     gene            complement(18937..19260)
                     /locus_tag="KAI37_RS07520"
                     /old_locus_tag="KAI37_01524"
     CDS             complement(18937..19260)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003331885.1"
                     /locus_tag="KAI37_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01524"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_025723962.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIISAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLMAVLPTLVTALWSKNLLATVVVGIVSMAVVR
                     LLW"
     gene            complement(19257..19982)
                     /locus_tag="KAI37_RS07525"
                     /old_locus_tag="KAI37_01525"
     CDS             complement(19257..19982)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="KAI37_RS07525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01525"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_023987840.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGVLLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLAWWVPSH
                     IAVIIATMITATIGVLTDK"
     misc_feature    20002..20015
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            20137..20310
                     /locus_tag="KAI37_RS07530"
     CDS             20137..20310
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KAI37_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179085935.1"
                     /transl_table=11
                     /translation="MYLPIRFGRVPVPDDLAAASHPKAVFKCTPDEFFEMANGQELMMN
                     QSSSDVFIQGLF"
     gene            complement(20384..21622)
                     /locus_tag="KAI37_RS07535"
                     /old_locus_tag="KAI37_01526"
     CDS             complement(20384..21622)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="KAI37_RS07535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01526"
                     /product="MFS transporter"
                     /protein_id="WP_025723964.1"
                     /transl_table=11
                     /translation="MNLQTRKSRHMYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     LDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHMLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEDRTSLKTLTRDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWSTVKASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFAVSGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAISGI
                     ILYGYLKKRQELI"
     gene            22030..22578
                     /locus_tag="KAI37_RS07540"
                     /old_locus_tag="KAI37_01527"
     CDS             22030..22578
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="KAI37_RS07540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01527"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_029516544.1"
                     /transl_table=11
                     /translation="MDSMQYIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRREDLHPVIDEDGNYFVYPVFPYHAEK
                     KFEVFTVSLKPGFTHQAEKHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQVSDIHT
                     YRNDSDEDADFYVLIYYAD"
     gene            22679..23194
                     /locus_tag="KAI37_RS07545"
                     /old_locus_tag="KAI37_01528"
     CDS             22679..23194
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280639.1"
                     /locus_tag="KAI37_RS07545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01528"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_220030998.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRMNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQLQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDYPWEL"
     gene            complement(23304..24770)
                     /locus_tag="KAI37_RS07550"
                     /old_locus_tag="KAI37_01529"
     CDS             complement(23304..24770)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="KAI37_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01529"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_220030999.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLSILLTLSIFQMFSPKIASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGVNYNEARVAVASSDTVDGDYTYQGSFRP
                     LDYDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTINFGDGTTYGSQSAYVIPVEGA
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINIDTASGAVEGIT
                     TPIAIDPDAYYQLVNRKSNKPLSIIGNATTDGADLEQRANSGAANQQWQLKDAGSGYYK
                     IVNRNSGKLIGVESGTTTDGTVIEQWSDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            24998..25696
                     /locus_tag="KAI37_RS07555"
                     /old_locus_tag="KAI37_01530"
     CDS             24998..25696
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 6.4e-12. Score:
                     37.4. Matches aSDomain:
                     nrpspksdomains_KAI37_RS07555_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="KAI37_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KAI37_01530"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_220031000.1"
                     /transl_table=11
                     /translation="MKIYAIDTSKPEAEEHYEILVNRVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLACRQLKISNASLQFTYNAFGKPSLINAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADSRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELKAQPFIGFTTEGFTTEYCHFKQYELDQDYKMAVCAAHDQFAQQVQQLDIN
                     TLRLEVATQA"
     aSDomain        25307..25480
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KAI37_RS07555_ACPS.1"
                     /evalue="6.40E-12"
                     /label="KAI37_RS07555_ACPS.1"
                     /locus_tag="KAI37_RS07555"
                     /protein_end="161"
                     /protein_start="103"
                     /score="37.4"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADSRLSYFYDLWT
                     LKESFVKAEGQGL"
ORIGIN
        1 taagcatctg atgcatattg tactgaattt gctggataat gcagtgaagt acaatcggga
       61 cggtggatgg attacgttat cgaatcgagt agaacaggac accgtgattg tgtgtatacg
      121 caattccggc ccatggattc ctagggagca atgggacatg atttttgagc cgtttgctac
      181 cttaagtcgt gatcgatctc gtcaggacag cggtacggga cttggtcttc ctctggcgcg
      241 cagactggcg gagcgcatgg ggggagagtt gcagcttaca gcttcagatc atagtgggtt
      301 ggaaaatgac aacgggcata caaatgtaag tgggaatgaa ttttcgctta gactccctct
      361 cttggttcac gatggctccc tgtaaacggc cgattgttag cacagggcta aaatggtgtc
      421 ttgtttacaa cttggaaaca atccgatgta ttcatgagat gttcgggcat taaactgggg
      481 gtatcgttaa caaggaggcc gttgtacatg ataaagaaaa acatagacag ctatgggcaa
      541 aagaacggct cccctcgtcg cgaagattcc cgcacaagag ttttcagaca gaaagctacg
      601 ggggtgctca tggccggctt aatcgccggg ggattgctca gcggttgcgg catgaaaagc
      661 gcaggagaga caaatccagc atccggtatg aaaccgggcc aacagcttac tgtgattgac
      721 acggatgcag cccagcagca agtaacggac gagctggtgg tatcgtctat cgacaggctg
      781 ggggatgtct acgcgaggtc ttggctgagc gacgaagagc tgattgtgga gcgtaaaacc
      841 cagctgtgga ttcataatgt agagacggac aaggagcgga ttttaacacc aggtcgtaag
      901 gctccgcagt tacttgctgt ggtatcaccg gatcagcgcc atgtcttttt tactgaaggt
      961 agcactagca gcaaatatga tatccagggc tacattttgg agctaagcag tggtaaggtt
     1021 acaccgatcg gcaagctgga tatgactaac gaagtgagct ggagcgatga gaatgatctc
     1081 attacaggca caccggatgg taaaatccag ctgattggtc tggacggcaa agctaaagaa
     1141 ttgagttttc aagatccgaa tcgctctgaa ttgatgtctc atgtcgaaaa agtgggtaac
     1201 gccatatttt atacaggcag tgataaacaa gggtatccgg tgctgaatcg gttcaccctt
     1261 aatcatcctc aggctgtgac tattgcagag ggggccatgt cctttgccgt gtcgcctgat
     1321 ggtaagtcta ttgccattga aaagcggaaa tggaatacat ccgaaccagc ccgtatgatc
     1381 attttggatg aacagggcaa agagaaagga atcgtcggtc aaggcacttt aatgagtcgt
     1441 ggaagctggt ccagcgacgg gtccaagctt gcttattcca tttatgatga ggatcagcaa
     1501 ggcatgagag ggctgtatgt gtttgaccag tccacgggta aaaccactcc ggttacgacc
     1561 gatatccaat cctatgacag cccaacggta tggagcccat ccgcccggtt tctatccatg
     1621 taccagaaca tctcggaagg tggaaaacag ctcaatcaaa gctacatcgt cgaatttaag
     1681 aggaagtagt ttctggaccc agtcgtacac gaggctcatc gttgacaagg aaatcatacc
     1741 agcggttgcg aaaccgaacc tgaggtccat cagcggggac gtgtgcctcc attcgcagcg
     1801 cttctgggat tggacgcgga tgctggcttt ccaccacggc ccgatcctct tccagcacct
     1861 taccactgta tctcgaaaaa atgtggctca tgcccggtac aaatctggca aaattacgtc
     1921 cagccagtcc gtagatggca gttaactctt gctcaatcgg agtgaaggtg acgaaattaa
     1981 taaacttgct gcgtccttcc ttggcgggag tcaaaatcca ttgctgtgga aaggtatatt
     2041 gtaatagacc tttcccgttt ttcactcgaa tatgattgtc atccgcttca aactcgatat
     2101 gaatgtcggt ggaggatttt ttaccgattg ttttgttatg gacaattggc aaatgagcga
     2161 catccagcac gctttccaca actctcgtca gatgtgcctt ccacatggaa tcgtagggag
     2221 acaaaatgag agaggggtcc tccagctcgg gaaaaatctc cagaggaggt ggggatgtgg
     2281 atgtccccaa ccctgagttt atttcagaat ttgagccaac ggcctgagga tatacccaca
     2341 gcaggccggc tttttcagtc gcgggatagg cataggtatg agcaaactca ggaatagccc
     2401 gtcccggatg tgccggaata tcgacacact gcccactctc atcgaaagac catgcatgat
     2461 atgggcatgt gatgtgcccg ttttgacaat agcctagcga caaatcagct cctcggtgcg
     2521 ggcaataagc atggatggca tgtacctgac gatgatcatc acggtacagg acaatatctt
     2581 tgccaagcag tcgcttttta agcggtttat tctttagttc cttggaccag ccaacggcat
     2641 accaggcgat tgggaatacc tgctgatcac tttcacgaac ttcacgaaag ctgggatggg
     2701 tgttcatcta tatcaacgct cctcgttctg cttctcaact atgacccgtg ggtcatttat
     2761 catattagta taatacaccc ctgaaccaaa acgaaacagg tgtcctgaaa ttggcaagaa
     2821 acgaaggtcg cttaaggttg tatgaaatag taagaaaagg cgcatatcct ttttaggaat
     2881 gcaccttttt taaattaggc tggctatttg atttggtatg actatacaaa cttacgatga
     2941 tgtttcttac cgtcatatga gaatagggcg agcttaccct caatcaatgt ttccaaatga
     3001 acggtgcgtc cccacagctg atatacatat ggaagcgtgc gctccatata ttttaaatcc
     3061 agctcaatgc cttcgtactg gtgcttgagc ttcaactcgc ccgtatgcag gtaatctcca
     3121 tcctcgacga cgatataagg ggagcctcca ttcacacgtg aaaacacaag ctgatctcgt
     3181 atgttttccc aggatttatc ggtaattttc caatcgggtc cccgtttctc aaacacgtat
     3241 agatccaaat cttctgtcag tttcttggtc atgtaattgc gtataaaaga agtgtctgag
     3301 tcgaactctc gtacctcgaa catcttagcg cgtccttcgc ccggtttgcg tccttgtcgc
     3361 tcttgttcct cacgggttgg gttatcccat cgtttttcaa tatcctcaaa tattttcagt
     3421 cccaaatagt acgggttcag gctttgcttg gaaggctgta cgacagaggc gttcagcatc
     3481 gcaaattcaa cggtttcctc cccggtcaaa tccagttccc ttacaatccg ctggtgccaa
     3541 taggaggccc agccttcatt cattattttg gtctccattt ggggccagaa atacagcatt
     3601 tcgtcccgca gcatcgtcat aatgtcccgc tgccagtcct ccagcacctc tgagaattcc
     3661 tgaataaacc agacgatatc tttttcaggt tccggtggaa actggcgtac tttgatgccc
     3721 tcggtctcgg ccggatcatg ctgcttcact gtgtccagtg accacagatc atcgtaaggc
     3781 ccagggggac gttggcgttt tccaggttct ttctgctccc gaattttgag ctccatgtaa
     3841 cgctgtttat ccagatgcct tggtttgatg atctgtggat ccacatgctc ttgtatcgcc
     3901 agtacagagt caatgaagga ttccacagcc tttgaaccgt attccatttc atagctgttg
     3961 attcgatctg ctgtggccga catactctcc accatattgc gattagaagc tgaaaagcgg
     4021 gcgttgtgtt tgaaaaaatc acagtgtgcc agtacatggg cgacaatcag tttattttgc
     4081 accaaagaat ttccttccag caggaaggcg tagcagggat tggagttaat gaccagctca
     4141 tagattttgc tcaatccaaa atcgtactgc attttcatct tgtgaaatgt ttttccaaaa
     4201 ctccagtggc tgaagcgcgt gggcatacca taggctccga acgtgtatac aatgtccgcc
     4261 ggacaaattt cataccgcat cgggtagtag tcgagcccga agccatctgc aatctccata
     4321 atttctgata tcgcatattc tagctccttc tggtcggtgc tcatcccacc gttccccctt
     4381 cccgtttgcg aaaaaaggta cgtaaggctt ggtatacctc acctttttcc ttgatgacat
     4441 agtacataaa ctgatccttt ttaatattct tgtaggctga catcagcgtg ctgctacgat
     4501 tatattgatt cacttctcca tagccgaaca tattactccg ctttataagt tcctcgatta
     4561 gcttcacaca ccgctcattg tccgaggtca ggttatcgcc atccgagaaa tggaagggat
     4621 aaatattgta gctggaagga ggatatcgtt tgtcgataat ttctagtgct ttcaaataag
     4681 cggaagagca gatcgtgccg ccactttctc cgcgggtaaa aaattcttct tccgtaacct
     4741 ctttagcctc ggtatgatgc gcgagaaaga caatttccac cttttcatac tgacggcgca
     4801 aaaagcgggt catccagaaa aagaagctgc gagcgcaata tttttcaaaa gagcccatcg
     4861 agcctgatgt atccatcatg gctataatca ccgcgttgga ttggggaatg gtcttctctt
     4921 cccatgtttt gtagcgaaga tcgtccggac taatatgatg aatgcccggt ttcccttcac
     4981 gggcgttgcg gcgcagattt tcgagaatgg ttcgtttctt gtcaatgttc gcttgcatgc
     5041 cttttttacg tatatcattg aacacaatag attcaacctc aatttgatcc ttgtcttttt
     5101 gctgtaaatt cggcaattcc atttcctcga acagcatatc ttccagttct tctatgctga
     5161 cttccgtttc cataatatcg tgtcccggct gatcgccggc tttctcacct ttaccaggct
     5221 tctgggaggc aggatcacgt ccgatgacat cccccacctg actatctcca tccccttgac
     5281 ctacatgctt ttgcttttga tagttataaa tgaagcgata ttcatccaga ctgcgaatcg
     5341 gcactttgat aatctgttga ccgtccgaca taataatatt ttcttccgtt atcagatcgg
     5401 gtagattttg cttaatgaca tctttgacct tctgctgatg acgttgctgg tcctggtacc
     5461 ctttgcgatg cagcgaccaa tcttcgcggg atacgacgaa tgaatatggc tggcgtggtt
     5521 ccggcattat taggcacccc ccaagtggat acacggcaca gtttggcctt gttggttatt
     5581 aagtatattc acggggatga acgatatgtg atggaactcg atttaaattc tgcccgtttg
     5641 cttttataat gaaagtaaaa aatgtaaaaa aagaatggag aaccttgggt tatggaagaa
     5701 attgcagtac ttatagtaga cgatgagcag gggttgcggg atatgctgac aacggtgtta
     5761 aaaaaagaag gattccttca agtcaagcat gctgcaacgg gtcgggaagc gctgcaagtc
     5821 gtgatggaat ctcatatgga tgtgattgta cttgatgtca tgctgcctga tagcgatggg
     5881 tttgaggtgt gtcgtcaaat gcgtctatat acggatgccc ctattctttt tttgacggca
     5941 agagatacag acctagacaa attaatgggg tttggtatcg gaggggacga ttatattacc
     6001 aaaccgttta acccgctgga agtcgttgcg cgtatgaaag ctcgaatgaa atatcggaaa
     6061 gtttcgacag tggccatgaa accgacctta cgcactttag attttggata ttttcgtctg
     6121 gagctggaat ccggtgtatt gtatgtggag ggaaaggagg tcgattgtcc ggcacgtgaa
     6181 tggctactgc tggttttttt gtgcaagcat cctaaccgga ttttcagtgt acggcagctt
     6241 tatgagacga tatggagcga ggccttcttg ggtgatgaga agaccgtagt gattcatatc
     6301 tcccgtttgc ggaaaaaaat agaacctgat cccaagcacc cgcaattttt aatcaatgta
     6361 agagggcttg gttataaaat gatgtcagtc aagatggggg agcaagaatg aactctctgg
     6421 ttaagatgtc ctttcgcttt atgaaagtaa cgttatgctt tgtactggcc tatgtcctat
     6481 gttttgttat ttgcacgatc ttatatattt ttataaaaag tatatttgga gcatctcaaa
     6541 atataaatat tgatctattc tggacaggac ttggtatcgt gcagagtgtt gtgttcatag
     6601 ctgcctacgg atggtatata ggcaaacctt tggtgtatgt aattaaatgg attggaaata
     6661 ttgcgacagg ggaattccaa gcgccgctaa gtgaactgga actgccagag ggcaaaaaaa
     6721 atcagaaaaa tagttataaa cctccgtatc aattgtataa agaagttttt gaacaaatga
     6781 acatcttatc ggctcaattg cgcagcaatg aggaagagag agtggaatta gagaaacgta
     6841 aacagcagtg ggtagcaggt gtaggccatg atctgaaaac accattatct tatattgaag
     6901 gatatgcggc tatgctaact gctcaagagt atgactggtc tgaggaagaa agaagaagct
     6961 ttagtatgag tatcagtgag aaagtgactg aaatgaagca gttgattcag gatttgaatg
     7021 cttctatgca gcttaaggaa agtccattgc caatccaatt ggagaaggag gacattgtgg
     7081 agtttctccg tagtacagtc atagatatcg ctaaccatcc ttcggctgag caatacgaat
     7141 tttcttttac gtcaatggag gcggcatgta tcatgccctt cgatagcaaa ttactaggca
     7201 gagcgctgca gaattttttg atcaacgcga tcattcataa tcctccaggt acacacgttt
     7261 ccatggaagt aagtaaaacg aacgataagc ttcatatttc tatcgaagat gacggaatag
     7321 gaatgaatcc caatgagtac atgcagatat ctcattccca agggcatgga atacctattg
     7381 ccaaaagctt tattgaggcg cataacggaa cgcttcatat cctttcaggc agtaaagcgg
     7441 gtactaggat ggagatttca ctgccgctaa acatctaact ttttaacatc taatctcaca
     7501 tttcgcagtt tgctcggttt tttttgcctg ttgtttaggg actgtttact tgatgtttac
     7561 tttacttcag taaactatat gtaacttaag cttcagcatt agaagtcgag aggagatcag
     7621 gaaatgtctg aatatgtaat acatacacag cagctaacta ggcgttttgg aaaacgggaa
     7681 tttgtaaaac gaataaatct ccaggtaccc ggacagcaga tttatggatt tttaggacct
     7741 aatggggcgg gtaaaacaac cacgattcgt atgctgcttg ggctgattaa atccacctcc
     7801 ggagaaattg agatttttgg gaaaaagctg aaggatcagc gtatggaaat attaaaggat
     7861 gttggttcct tggttgaatc acctgcctat tatgcccatt tatccgcata tcgaaattta
     7921 gaaatcgtta caaccatgcg tggactgccg acccgaagaa ttcatgaagt gctggattta
     7981 gtgagattag ccaaggatgc gtatcgtccg gtaaagggat attccttggg gatgcgacaa
     8041 agactgggga ttgctatggc gcttattgcc aaccccaaat tattgatact tgatgaaccg
     8101 acgaatggtt tggacccatc tggtattcag gaaattcggg agttaattat gagccttcct
     8161 ggtgcttacg gaatgacggt actggtttcg agccatttat taagcgaaat tgagcagatt
     8221 gcaacctatg taggaattat taatcagggt gaaatgatct tccagggaac gatgaaggaa
     8281 ctcaccgcca aaagcaagcc tcaattattc attgaaaccc cagatcctgt tctggctgcc
     8341 ggtgcactga ttcagcatgg gtggacggcc ggagctgaat cgattgaaca aaatgaggtc
     8401 gtgactccta ttgtagatcg gcaacaatct tcggagatga tcaaggtgct tgtggaacac
     8461 aatcatccca tttatcgggt cacagagaag aaaaaaacat tggaggagat attcctggaa
     8521 ctgacaggta aggagcgaag cttatgatac tccgggttat aaagtcagag gggcttaagc
     8581 tgaagaaaat atgctggtgg attcctctta tacaggggtg tgtacttaca ggcatgactg
     8641 ccgtggaatg gtatctttac tttcggcaag gaccaggagg tgtctatgct ggttttgccg
     8701 ttatgtttat gttcctttcg tttgtgatgc tgcttggcgg tacacttttg gcgagcatta
     8761 tggctggtac agagcatgat actcaaacat ggaagcagct tatggtcatg cctgttccca
     8821 gaagttatat ctatttatcc aaaattgtat ggatcgtgat tctgcagttg ggtaccgcct
     8881 tgatcactgt agcaggtatg agcctcatct gggtgttata tacaaacgaa cccattcctt
     8941 ggcggatcat gctgttacag ccgattaatg caagcttggc taccctacca gtacttgcaa
     9001 ttcaactttg gctgtctacg cttttcacta atcaggcatt cccattagcg tttggtatat
     9061 tcggttctat tgcaagcttg tttttggcac gcacaagtat tctgtggatt aaaatattgc
     9121 cttggtcgta ccctgcacta tcaagtcctc tgatgaagga acacatgatt tgggtgatcg
     9181 ttgctttaag cgcaggagtc atctttacgg gacttggtac attacagttt accaagcatg
     9241 aattcaaata gagaggagaa gatacatggg ctctatttta cgcgtggaga caataaagct
     9301 tcaatggatc atggtatgga ttctcattat attggatgcg gtcataaatt ctttaatggg
     9361 agtcctggaa ctgaatgatt tgaaacagtt tttttcgccc agttggttaa ctttatatac
     9421 ttattcagcg caatttcact ctatgttttt ttatccgctc tattgtggaa ttatcgcttc
     9481 tcttttgtgt gcgtacgagc atcgggatgg gggatggaag attttattaa gtagcccgta
     9541 tcctcgtcag caaatttatt atgcaaaata tatattgctc attctcatac tgggtctgga
     9601 tcagcttata tttatagcag gctattttgt aagtggaaat atagcaggtg ctccaggaga
     9661 aatcccttgg tctgtcgttc tttctaccgg tttgggaggg tggctcggga tttttcccct
     9721 ggcagcacta cagcttatgc tctcgataaa aattcggaat tttggagctt ctctgggaat
     9781 gtctatttgt tgtgtggttc ctaatattgt cataacaggc tttcactctt ccataggtgc
     9841 gtggtttcct tttacgattc cttattatat tatgatgccg caaacagcga cttatgcacc
     9901 cagagttgag ccttacagtc tcggactgat tgtcattttt acgtttttag cctatctgta
     9961 tggtggaaga aagatgtttg tgaatagaga ctggttgtag ttaggatagc atgaggatgt
    10021 aatcccaacc gatctctttg ttctcagaaa cacttaataa agcagctgca atcccagcaa
    10081 cgccttcaag catgcccgct tttgtcagcc aagttaaaga gccatctgac cttggctcgg
    10141 ggtccagata tccaagtggg ctatccattt gaaagcgatc aagcagacaa ttcgttaact
    10201 gttgaataag cgggaaaaac gcaggctctt tactgtgaca ccacattcgc caagagatgg
    10261 taagtaatcc ggcaagaccg tgacagagtg cagaagagtc catttcccgc ttagctatct
    10321 catgggagat tgcaccgaca caagctttca cagccaattt ttgcagttct tcattatgga
    10381 gagcctttcc ggcaagaaat agcgtacagg caatgccggg ggtaccgtaa caccatgctt
    10441 ctcttgctcg ttccaaatca aactgtagag agcctgtttc agcttcgaat ggaacaatat
    10501 gaggccagta gctaccatat tcatcttcat atttatactt aagcaaccat tccgcaatgg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccagc actgtaagct acagataata
    10621 aagccaacgg tccaggaata ccgtgtgcca ttccacaatt aaaattgccc agaggatagt
    10681 tacgtttatc ccggtctaaa aattgaaact tttgcgggga gtaccaccct gggacataac
    10741 gattgtgaat atgtatggga tgtgtaagat cggtaagaaa ttgaagaatt ggctcaacaa
    10801 gaggagtaca gataggatcg gttgagttca tcaaaatata tcttccaatc cctgaagctc
    10861 ccgaaatggt gtcaaaggct tgcatgggca taccttcgtg aaggcttaat tgttctgtgt
    10921 tcgactgaag ccattgctct gtaagaggca tcatccattg atgtatttgc tgtaagaaat
    10981 tactgtagta tttcccatga ttagaagcct ctcttacgga cgaagcgatg cctgcccagc
    11041 cactgtaaag agagagatcg tgaagaccat ttttagagag tgaggattga atctgagcca
    11101 tgtttgaatg tatggctgta ttccaatcat acgaagggtc tgtagcacgc cattgcgata
    11161 gtaaatgaat gttaccagga taaccatgcg aaagtgaagt ttctccccat gggtggtact
    11221 ttgtttctgg cgaaacattg tgttccgatt ggactgctgc atagacggat tcgggctcgc
    11281 atagacgtaa agcaattttt ttactaatat ctcttgcacg aacttggtcg gattgttgta
    11341 taacaaaact atcaattttc atatgaaagc ctccattatt tttttcttca ttatattgtc
    11401 actaaaatct agtgtgttgt ccttaaaaat actgaaaaat aatgaaggtt tatcttaaat
    11461 gtactcgttg aaattaagaa aaatgtaaga attatataaa gtctagttaa gattatataa
    11521 cttataataa aaatgtaaaa aataaaagga ggtaacaaga tgaaaaatca atttgatctg
    11581 gacttgcaag tagctaaaga tgaggttgct tcaaaagggg ttcaaccagc cagtggtatt
    11641 atctgtactc cttcatgtgc aacaggtact ttgaattgtc aagttagtct taccttctgc
    11701 aaaacgtgtt aataacgaaa atacatggaa aaaaggcacg gtttctataa ccgtgtcttt
    11761 tccagttatg aaaatgaggg aaggatttat ggttgaagat ttgaagggga gatcagttga
    11821 aatcagtaag tatatagcac aaaagctaat agacctatca tatacagaaa agatagttaa
    11881 tcatacaaac aacctttcac cttcacgtgg aaatccccct tggaatcccg gctcgcttgc
    11941 cgatggaatt ccgggtgtgt ttgcgctgtt gtccgaatgg ggttacctgg agccagatca
    12001 aaattgggca gagcatgtgc atagtcagtt acggtactta gatgctaact ctctattatt
    12061 attgcctcgt atttctcttt attatggaac aacaggagta gcttatggca tattattagc
    12121 ttccaataac agagctaatt ataacaaact aatctctcag cttaataagt atattgaagt
    12181 aaagtggggg gatttacctg taattggcac aattacagag ttcagtaggc aaatggatat
    12241 cattaatggg ctgctcgggg tgggcagata cactctggag gttgctgaag acaagacgat
    12301 gtgtgatctg tctcgtcaat tattagacac cattacgcac ttcatacctg aatatataca
    12361 tttatcgtca agggaagatt cggcttcaat cgatctaggt ttggcgcatg gtatcaccgg
    12421 aatacttgca ctgcttgtca ctgccctaca aaaaaagatc aaagttgaag gactacatga
    12481 ggctataaaa catatagccg attttttgct tattcaaatt caggaggatc aatatggctg
    12541 gtattggcct gtaaactctc aagcatcttc aatgaacaag agagagaaaa aagtagggat
    12601 gagagaaatt gaaggctggt gtcatggaac ctttggaata gcttggacat tactcagagc
    12661 aggaattgag tgcagtaatg aagaatggaa aaagatagcg gaaaaagcta tggaatccat
    12721 attttgctta gatgatgagc tactaaacgc gctatcccct actttctgtc acgggttggc
    12781 tggtttgctt catatggccc atagattctc tagcttaacc gataatatag cagcgttacg
    12841 ctttgccgat cagatagctt taaagttagt aaatttatac gatgaagaac tcccatttgg
    12901 ataccaggat ttggagggga caactcatgt tcataatgta ggaatactac aaggagcaac
    12961 agggattgca ttaagtttgc tggactatgg aattgggaaa gaacatccta aatattcagg
    13021 gagatggagt gaattgtttc taatttctta agggtgctac cttattgctt tatctgaagc
    13081 attggttttg gagggattag atgaaacaaa aatttatggt tatatcatct tttaggaaga
    13141 tcaagcattt ttttgagact ttaagcactc cagaaaacat tcaaatcatg ttttatgatt
    13201 cgctttacca ggctataacg gagattgatg agcagtgtat cggtgtagct ttgaatcagg
    13261 atcatataac actagaggac ttgtcttact ggcacagcat taaagaaaaa tttaaggttc
    13321 catttatctt tctttcctat catagtgacc aacagcaatt ggatctcctc aaacaactgt
    13381 tttcaatggc atcatctaaa tatggaatgg aaagagaaca gcaggctatt agtttatcac
    13441 ccaatgtcat ttttgatcct gctggaaagg ttatttggaa gcaagggcat gagcatatgc
    13501 tgactatgat ggaatttcga ttattaatgt atcttcttac tgcaaaagag tgtgcttcta
    13561 cgattgatca cattatagac agagtctggg gagtggatgc ttttactacg tctaatacgg
    13621 tgtatgtgca catccgaaaa ttgagagaga aaatagaaga tgatccaagt catccaaaaa
    13681 ttctggtaac atgtcatgga atcggttaca agttgaatat atttcctaaa aacttggagg
    13741 tggtcagttg tgaagagaca actgcattac actgatgcgc ataaactaca taatgaagtg
    13801 agagatcggg atgaaagatg gtttagtgca tgtgattttt ttctaatcag agctccatta
    13861 ctatcgctag accaatattt tcaggtgttt tcggatcaag atgtggacag ccagcttact
    13921 ttggaggaaa taactcgtcg attaaagttg atatcccaag aagctgttgt tcaagaagcc
    13981 atatcattag cctctccgtc cctaatgcag tttctacatt acttgaatga tggtcatgct
    14041 ttggatgata aaggagagct acaaaagtat gagaagacgc tgaacagctt ttatcgttat
    14101 tttattcgga tgactacccg aacgactcca tttgggttat tttcaggagt ggggcagggg
    14161 atttgcggga agactaccga tctggatatt ggtagctatc ctaagcatct gaagagagcc
    14221 agacccgaca tggaatggat atataaactg attcaaaaaa tagaagctga tccagccata
    14281 tttaatcaac ttaaggtctt cctaaacaaa acggttatga tcaaagggaa tcgagccaaa
    14341 ttaccattcc gacctaagca tggagcagca gaagctgatg attcggcaga aatttttaat
    14401 tccattcggc ttactgacgt tgttcgaatg acgtttgaag ctgcggaaca tcccattcgg
    14461 gtgatggaac tcaaagaaat actattaaag gcattccctg acgctacttt ggaaatcata
    14521 gctgattatt tgcagcaact agtagagcaa gagtttattc tgagcgagct tagacctccg
    14581 ttaatggatc attcaccctt tcattacata ttcgaaaaaa ttaaaaaact ggacatttcc
    14641 gatccttgga ttcacatttt acacgaaatt gatgctttat tacttcaata taatcagtgc
    14701 acgattggag aaggagagaa ggtctaccgg aaattatgtg acaaaatgct ggatatcatt
    14761 tctgtaaaaa cacctgtaca agttgatgtt aaattggata aagaagtaac gctgccgaaa
    14821 catgtgcttg atgaggtttc attaggggct gaagtcatgt gcaaattgta tgcatccccc
    14881 aaaacggacg aattggatga atatttgaat cgtttcttgg aaaagtacgg tgtgtatcag
    14941 gaggttccta ttcatgaact gtttgatgag gattggggtt tgggtatacc ggaaatgtat
    15001 cgttcaaatg aaaaaaaatc aatgggcatg gaggctttta aacgcaacgc tgttctcttt
    15061 caatgggttt cggatgccat ttctaatcat gaaatagaac tcgcccttac agatgaacaa
    15121 ttagagcaac tgatgatttc tgataactac gacacttccc cagaatcaat ggagatttat
    15181 tacagtatat ttgctgattc tcctgaaaaa gttgattctg gagactattc gcttttactt
    15241 ggagccagtg ctggctcgaa tagagcgggt aaaacctttg gacgttttct ggatatgttg
    15301 agtgaggagt ttgtacaaaa attctctgaa atatatgatc atcaccgatg ctttcatccc
    15361 gatgcgttat tgtcagagat ggtttttatg ccggaacagg ggaaaatatc aaatatctca
    15421 ttaagcaaaa atttaatggc atatgagatt gtgtcgggaa ccacctcttc taaagatgag
    15481 gaccatacgc tctgtattga tgatttagtg gtgggtgcta ctcatgatcg tttttatgtc
    15541 aagtccagac gtttgggtaa ggaaataatc cccttgcaaa cacacatgct gaattacaag
    15601 ctttcaccac atatattcag atttctaacg gatattacca ataaagagat tggtacgtgg
    15661 tcttattttg actgggggcc attagagcaa tccccttttt tgccaagact agtatataaa
    15721 aagatcatta ttagtgctgc gcagtggaaa ctgagcaaag cttcattgaa tatttcagaa
    15781 tcatgcgagt ccaaagaagg agaagaactt ttccatgtgt ggagacaaca atggaatgta
    15841 ccgcgttatg tttacctaac gatgggggat aatcgccttt tattagacct atgcaacctt
    15901 ttccatatca aagaattgct acatgaggtg agcaagacac gtgaaggaca ggaacttctt
    15961 cttaccgagt gtttgggtaa tcccttccat accccagtac aggggacggc aggaagatat
    16021 atgggagaat ttgtgtttcc actaaagaag aaaaaaataa aggtgaaacc gagtatccct
    16081 agttcacaaa accatattgt ttctcaaaac ttcattactc atactccttc cagcattcat
    16141 agaggcatat ttccaggagg ggagtggcta taccttaaat tgtacggaat caaggaaaga
    16201 gagactgacc tggtaggctt aagcctaggg catctcttaa aacagccggg gtttaaggat
    16261 tggagtcaaa aattttactt tttgcgatac gttgatcctg aacatcatat ccgtttacgt
    16321 tttcagggag agcccgataa gctatggaca gctggtttgg cgcaattaaa tcagtgggca
    16381 gccgagttac gtgaagaggg gctaataaca aatatggtca tagatacata ccatcctgaa
    16441 tgggagaggt atggaggaca gacacttatg gagctggcag aacaggtttt tgacgtggat
    16501 agtcaatggg tcatcgccta tatgaaggga attcgctcta atgctttcaa tctggacata
    16561 gagattgtgg ctgtgatgaa cattattcat tatctgagtg gttttggttt aacgattcag
    16621 gagcaagtga aatggctaga agagagaatt gattgcaagc ctcatatgaa ggcattcagg
    16681 gatgtcaaaa aaacattgat taccgctgta gagtcgaatt atgaatggat tggacaagca
    16741 gatacgaaca cacaggttgc tttcttagcg cttgtagaaa aaagacagac tatgattcag
    16801 aagtatgctc aagcgataat cctggctaaa aataatcacg aacttaccaa tcatcctgat
    16861 gatattttag gcagtatcat tcatatgcat ttgaatcgtc tgcttggtgt aaatagggag
    16921 cgagaaataa aatgtatggc tttagctaag catacagtag ctaacctgtt gcataggaaa
    16981 ggggtaagct atgtcacagt ctgatggaca aaccaatgac ctgatctctt tgtcctataa
    17041 aaatatattt cgtacctttt tattttggcc tcgtatattc aggctgcttt gggacacaca
    17101 tccttccttt ttgattgcta tactcattac gaatttattg aagggcgcaa ttcctgctgt
    17161 gatcctttta actacgagag aattaatcaa cagtgtcgtg gccggagcgt caggaggaag
    17221 ctttcaacct gtttttatag cttttggcgt cttgatcggt gtcaatttgc tgtacgatct
    17281 gatcaatatt ggcgaaagct tttttcgtaa aatgtttcaa agccggctat cgaaccaggt
    17341 aaatatcaga attattgaaa aagcacaaaa gatgtctttg cagtcgtttg aggatgcaga
    17401 tgtgcaaaat atgctccaac gtgctcaggg agaggcagat tttaggccgt ttgaaatatt
    17461 tactcaaatc cttgccatta ttagcagtgt tgtaacctta ttctcgacgg gtgctattct
    17521 catcgcatgg agatggtggg cgttcttatt catttttctc attccatgct tatcatttta
    17581 ttctttttta cgtatcggac aaagagaatt taatgttcac tttcaaagag caggaagaca
    17641 acgtgaatcc tggtatttgt cgtttttagt gacaagagat aatagtttta aagaagtgaa
    17701 aatatttcaa ttgggagact atctgcgaaa aagatacaaa acgatactcg aagggtttta
    17761 tcgcgaggat aaagtgctag cagttcgtag atcctatact tctcttgtat ttcagattgt
    17821 aaatcagggt gcgtgtgcat ttattatttt catggccata caagccactt atgttggtca
    17881 aattttagtg gggaacttgg tgagcttaat tcagggtatc acgttaaccc agtcaacatc
    17941 gcagagcatt gtacaaggga ttttaagctt gtgtcaaaat aatttgtata tcaagcagct
    18001 atttgacttt ttggatatgc cggaagaggc aaaaatacaa aaatcagttc agcaattgcc
    18061 tttgtccgct attcacagta ttgaatttcg gaatgtatcg tttagatatc cgaacacgga
    18121 ggagaatgcc atttctaatg ttagcttcaa gcttcatcaa ggagagaagc tggccattgt
    18181 agggaaaaat ggatcgggta aatcaacaat tgtgaagtta atgactcatt tgtattccga
    18241 ttttgaggga gaaatcttaa ttaatggaca ctctatacat gaattggata aagacagttt
    18301 tagagccaaa ataggcgttg tttttcagga ttttgtacat tatgagatgg ctgttagaga
    18361 taatataggc tttggtaatg tggcttccag agaaaatgat gaggctattt ggacagctat
    18421 agataaggcg ggaatcacag atttgatagt cggcctgcct gataaaataa atagcttgct
    18481 tggaaaatgg tttgaagatg gacagcagct atctggagga caatggcagc gtattgcaat
    18541 agctagggct tttatgagaa atgccgatat atatgtcttg gatgaaccga gctctttttt
    18601 ggatccacac gcggagaaag aggtttttca aaagtttgat cagcttattc atgagaaaat
    18661 tggagtgttt atttcacaca gattgtcctc tgcacgtatg gccgatatca ttattttaat
    18721 ggaggagggt agaattgtag aagcaggtag ccatgaacgc ttaatggata tagacggagt
    18781 gtatgcagaa atgttcaggc tccaagcctc ctcgtatctt tcacaacgag aacgtggttt
    18841 tgaggaagaa aatctgtcgc cctcgttagt aaggacgaca ggtggatcat aagaaaggac
    18901 agatgccctc ctattgtagg agggtaattt ttatcttcac cacaaaagtc gaactacagc
    18961 catactcaca ataccgacaa cgacggtagc cagcaggttt ttgctccaca aggcggtcac
    19021 tagcgtagga agaacagcca taagcacttg cccattaaga gtgactgagg tctcggttcg
    19081 aacgagcaga ttttccatca cgagggccgt gaatatgcag atgggaatat aggaaagcca
    19141 ttgtagcact ggcttgggta gcgccagcct ttgcagcacg acaaagggaa tgatccttgg
    19201 aatcgccgtg acaatcatgg cactgataat gatatacagg acattgggat taatgttcat
    19261 ttgtcggtta acactccaat cgttgcggtg atcatggtcg ctataatgac ggcgatatgt
    19321 gatggcaccc accaggccaa aaggtacatc agaacagcca tacatagcac aagcagcaga
    19381 cgatgcttga gtttggaggt ctggacactt tggagctggg aaatgagtaa ggcaagaaac
    19441 atcgcaggca aggcaaagtc cagaccaaaa gcctccggtc gggaaatcca gttcccgaga
    19501 acccctcccg ccacacagga tgcaatccag gcgagataag ctgtaatatt aagcccgttc
    19561 atccagcggt cactgacctg cccgccttta gccaatttat ccgatgctac tccaaaggat
    19621 tcgtccgtca aaagaacacc gatgcctatg tttttccaca atgaatattt agaaaagtaa
    19681 ggagccagcg atgcacttaa tagcaggtga cgagcattca caatgaaagt cgttaaaata
    19741 atgacggatg gaggactggc tgcagccagc atcgagcaca taataaactg ggaggctcct
    19801 gcgtatacaa gcgccgacat gaaggcaatt tccatggtgc taacccctga tgaggcaccc
    19861 acaatgcctg ccgcgaaccc aatacataca taaccgagca atgtaggaat acaatcttta
    19921 accccttgta aaaagctgag tgaatcgtgc ttcgttccgc tcaactccga agctatggac
    19981 attttaacct tacccccagt gtataaattt tataatagta tataacgtaa attgtaaagc
    20041 atcaatatat tatacgtttg tatgttatat tgaatagttc ctacaggaga attgctctta
    20101 aaaagctgtt ttactgttga caacccaatg aaggctatgt atttaccaat aaggttcggt
    20161 cgtgttccgg ttccagacga tttggcagca gctagtcatc caaaagcggt gttcaaatgt
    20221 actcccgatg agttcttcga aatggcaaac gggcaagaac tgatgatgaa tcaaagcagc
    20281 tcggatgtgt tcatacaagg gctgttttga ctgaatgggg aactcgtaaa aaaagggcgt
    20341 cccagtcagt tcatgactta tgggacaacc ctaaggtgat gatttatata agctcctgcc
    20401 gcttttttag atatccgtag agaataattc ccgagatcgc gcagatggct gcgcatagac
    20461 cgataactcc ataacccgcc tgaagcccgc gcagtatgcc aagctcagtg gttgcgccgt
    20521 agactatctt gactccttcg attacccagc cgatcacata gttgccaatg acactaccta
    20581 tgcccatcag cgtgacgacg aacgtaatag ctgtatcact gtccttcgga tatctccttg
    20641 ctatgaacgc catcacggtc ggatagatca ttgcaatacc tgcacccgat acggcaaaga
    20701 gaaacgccag tctctctcca cccgcgattg ctgcgaacgt acatatcgct gagaaggcgg
    20761 agaatagaat cgtcgaaagc acgaacccca tccggtctgt gagcggacca agcaacaggc
    20821 gccccaacga gaaggtaaga aagaacgctg agagcatgct ggacgccttc accgtgctcc
    20881 atgaatacgc tttctctaaa aagttgacca gccagccccc aactgcgagc tcagagacta
    20941 ctccaaacga caggatcatt accatcatcc agagtgctgg atcgcgggtt agcgtcttga
    21001 gtgaggttcg atcctcatgc tgcaaatcgt cacccgggaa ggtgctgagc agtgcggcca
    21061 caatcggcag caggcagagc gacaacatag ccagatacat cccccgccag tccagcatat
    21121 gtccaaatac cgtcagtgac atgactcccg tcgccagcaa aggggcgact gttgagctga
    21181 gcccatagaa aaagtgggac aaattcatca tcgtgccggt atttttcaca aaaatcctcg
    21241 cccccaaaat tgcgagcgca atctccagca tgccgttccc gatatacatc aagaagtagg
    21301 acgaggcgaa gaacggatac gtgtgcgaca ggtagatgaa cactcccgag atgatcatgg
    21361 aagcaaagga aatgatgctg accgccttga ttccccactt acggacaagg acagcggtga
    21421 acgagcaggc aatcaaataa ccaagtgcgt ttagagacaa caatgttccg agctgctgtt
    21481 catccagatt gaagtcgaat tggatgcgtg gaatggcagg gcctttaata ttttccgaga
    21541 tgccaaatac aataaagcca ataaaaattg tcgccagctg catcgtatac atgtggcggg
    21601 acttgcgggt ttgcagattc aaatttagtc cctcctagat agccaaactt gattttctca
    21661 cctgttgggt gttcagggac ggaaaagtca taggatagca gccctccttc aggatattac
    21721 aatagttttg aaaaaagttt taataagtga aaagtttaag gacattttta ttcaatgtca
    21781 aatgttttta ttgcatgttg aagtaagcga ggaacctgac catattacag taaattgtag
    21841 catgtctact tcccgtttaa gctttgtatt accttgatcg gctacactta atttactgtg
    21901 gataataagt cgtgcatcca aaattgcaaa agataaatga tattttacga tacagtctat
    21961 atatagcgaa cacacagtct tttgtgtatt cttcttatat agacttttgg atacaaggag
    22021 gcatcgtccg tggattcaat gcagtatatt attggctcta atttggctca aatcaggaag
    22081 actagaggat taagtttgga taaggtggct gaactgacag gagtcagcaa agggatgctg
    22141 gctcagattg agaaggggaa atccaatcct acggtaacaa ccctttggaa aattgcgaac
    22201 ggtttgcacg tatccttctc cacctttctt aaagaagacc cgccgcaaat cacgaagatt
    22261 cggagggaag acctgcatcc ggttattgat gaggacggta attattttgt ttaccctgta
    22321 ttcccgtatc acgctgaaaa gaagtttgag gtgttcacgg taagtctgaa gccaggcttt
    22381 acacaccagg cagagaagca tttgggagag gaaacgattc tcatgatccg tggggaaatg
    22441 tactttgaaa tgcaggggca acagctcaag ctgagtgcag gggatgctgt gcaatttcaa
    22501 gtatctgaca tacataccta ccggaatgat tcggatgagg atgccgattt ttatgtattg
    22561 atttattatg cggattagtg ggatgattag catagtctaa aacaggcttc cacatcagga
    22621 ttttgcaaaa tcctgagata taaaaagaga gcaacgagga aaagagagga aagaacccat
    22681 ggaaagcaag tacatccgag aaacctactg cttcaagacg tcccgagtat ttcccaacga
    22741 tatcaacaat cataacacgc tcttcggcgg ccgattgatg tcgtatatcg acgatatcgc
    22801 atctattgca gctgctaagc tgtgtcgtat gaacacggtt acagcctcta cggattcggt
    22861 ggattttttg ctacctatcc atccgagtga ttctgtcacg ctagaagcgt tcgtaacctg
    22921 gacaggccgc agctcgatgg aggtgttcgt aaaggtgatt cgtgaaggac tgatgactgg
    22981 cgaccgtaaa atcgcagcca ccgccttcct gacctttgtg gcattggacg agaacaaccg
    23041 taaagtgacc gtcccgcagg tgattccaga aacagaagag cagttacaat tgcaccagac
    23101 ggctccatca cgtgcagcca tacggcgtca gcggagggaa gaaagcaagc agctggctag
    23161 ttttctgacc acagattatc cgtgggaact gtaacgtact agagattatc aatttcatcg
    23221 ttttacgtaa aaaggagccg tcttttccgt tagcagtcac catgatctac tcggaatacg
    23281 gctccttttg aaaataactt gagctattct actttaacta cacggaaatg ctgattcgtc
    23341 ccaccattat cgccccattg aatggctttg gctccatcgg cggtggcgcc ttcagaaata
    23401 tcgatcagct tgccggttgc ccgatttttc agcttgtaat aaccaccggt tacggatact
    23461 aattgccaat gctgactgga ccagcctccg tcactccact gctcaataac tgtaccgtct
    23521 gttgtggtac cgctttcaac accaattagc tttccgctgt tgcggttcac aattttataa
    23581 tatccgctgc ctgcatcctt gagctgccat tgctggtttg ctgctccgga atttgcacgt
    23641 tgctccaggt ctgcgccgtc cgtcgttgca ttgccaataa tgcttagtgg cttattgctc
    23701 ttgcgattca ctagctgata ataggcatcc ggatcaatgg caattggcgt tgttatcccc
    23761 tcgaccgcac cactggcggt gtcaatatta atgctgtcga accaatccat ggctaatgaa
    23821 gtcgctgttg gaaaacgcag tggcaaccat acatattgag aatcctgcac aggaccgctc
    23881 caggcacccg cccaacggtc gcccaaatac aggtatgaag ttgtctgggc accctcaaca
    23941 ggaatcacgt aagccgactg tgaaccataa gtcgtaccgt ctccgaagtt tatcgtatta
    24001 ctccaggttc cttcaatgct ggatgcggta gcatacttgg cttgattggg attccagccg
    24061 gttgccccgg atgtaatcag gaagtagacg tctccttttt tgaacatcgc cggagcttca
    24121 cgatattgtc ctggccaaag tgtagtcacc agcgattcaa cttgcagaaa atccggtgtc
    24181 agacgataaa tgttcagatc cgcgtttact cgggtagccg aaatcaggta agctgtaccg
    24241 ttatcgttgt atacggtcat atcgcgcgaa tcgtaatcca gaggacggaa gctgccctga
    24301 taggtgtaat cgccgtccac ggtatcggaa gaagcaacag ccactcgggc ctcgttgtaa
    24361 ttaaccccat tctccttatg catccataat acgtatttac gtgttttttc attgtaaatc
    24421 actttcggac gttcaatatt cgaaacattc agctctacag cggagctgct ggtcagtacg
    24481 tttttacgaa actcccagtt ttttaaatca gaggaacggt aggcggatac cgccttgaac
    24541 gtgccgttgg gattacgatt ttcaccaaac caataatagt aaccgtctac tttaatcata
    24601 ccacccccat gggcatggac cacgtttcca tctgtatctt taaactgaat gccattcaca
    24661 acattcgctg aagcggctga agcgatctta ggagaaaaca tctgaaaaat gctcaacgtc
    24721 agcaaaatag agagcataat acacagcaag cgggcaaaat catatttcat tgtttcgtcc
    24781 tcctctgtat gcgttatttt aaagcgcttt cattaatggg ctctatgaag tagttttaat
    24841 agagatgctt atcccaattg tatccatatt gaattgaaag tgctagagta gtatattgac
    24901 catgtacacg gcacacgcca tccatatcta acagacttcc atcgaacggt gagtgttact
    24961 aactggctga tattcattag gtatacagga ggcaaccatg aaaatatacg cgattgatac
    25021 gagcaagccg gaggctgagg agcattacga aatactggta aatcgggttt cgctggaaaa
    25081 gcagcacaag ttagatcgtt ttttacatcg ggaagatgct ttgaggggct tatatgccga
    25141 tgtgctgcta agatggttgg cctgccggca attgaagata tctaatgcca gtcttcaatt
    25201 tacatacaat gcattcggta agccttcctt gataaatgca cccgcattcc attttaatgt
    25261 ttctcactcg ggaaaatggg tggtgtgcgc tattgatgat cacccgcttg gaatcgacat
    25321 tgaacagctc cgtcctattg attttgaggt aggtagagtg tgcttttcgg acacagagta
    25381 tgatgcgtta atgcgtcagg acgcagacag ccgattgtcc tacttttacg atctatggac
    25441 gcttaaggaa agctttgtga aggccgaggg gcagggacta accctaccgt tgaagtcttt
    25501 ttcattcgag ctgaaggcac aaccgttcat aggcttcacg acagagggct ttaccaccga
    25561 gtattgtcat tttaagcagt atgagctgga tcaggattat aaaatggctg tctgtgcagc
    25621 tcatgaccaa tttgcccagc aggtgcagca gttagatata aacacactac gcttggaagt
    25681 ggcaacacag gcgtaatatg aggtggatat gcgtatagtt gaaaaaagga gatgagtggc
    25741 gttgacattt gttttgttca agcacggccg gttgtatggg gagtgggctt ccaaaggaga
    25801 ctccatcgtt gtacagcagg gtcggataca agccatcgga tatgctcggg agcttgaatt
    25861 gcagttgacc ggtaaggaat atgaaactgt ggattgggaa gacgcctatg tactgccagg
    25921 cttaaccgat tcacatatgc atttgtctat gcatggtatg aagctggcta tgctggattt
    25981 aacatcagct acctccaagg aagagatgct ggctatgctg cgcaaacggg tcgctgtaac
    26041 accgccggga gagtggattt taggactcaa ctggaatgaa aatgcgttta ttcctgttga
    26101 aattccaggt atagccgagc tggatgccat tacagatcag catccggtat atctcactcg
    26161 tacgtgcttt catacgttct tggccaattc agaggcattt cggcgtgcag gtattagcga
    26221 ggacacccct gacccagctt cgggagccta tggacgagac gcagatggac ggttgaacgg
    26281 attaatttat gaggaagcat cctttgcctt tactagcgtg cagccagagc cggattattc
    26341 ggttaagaag gacacgattc ggcgggcttg cctggatgcg ctacggcttg gtctgactgc
    26401 tgcacacacg gaagatttac gttttttagg cagcgtggag acgatgcagc gaatttacag
    26461 ggagctgagg gaagaaggtc ttgtttttcg cacacaccag ctcatctatc atccatttat
    26521 ggaggaagcg aaagtgcaag ggctgcgtgc aggtaccgga aatgaatggt ttaaaatcgg
    26581 tgcgattaaa atgtttgccg atggcgctat tggtggaaga acggcattat tgtctgaacc
    26641 ttatagtgat gctccacata cctgcggaat ggcgattcaa ccgcagccag agctgaatca
    26701 gatggtggca gctgccagga ccgcaggctt tccggtggct gtacatgcta taggggatgg
    26761 ggcagcgcac atgatcctga cagcgatgga ggtccatgtg ctcacggagg aaagcggttt
    26821 gccagatcgt ctgatccatg gacagttgct tagaagagat ttggtcaaga gaatggtgaa
    26881 gctgccgctg attgcggaca tccagccccg ttttgtcgca agtgacttcc cttgggtact
    26941 ggatcgggtg gggaaagaac ggactgaata tttatatgcc tggaaaaagc tgctggaagc
    27001 aggc
//
