LOCUS       NZ_JAHWJB010000003     26568 bp    DNA     linear   CON 12-SEP-2024
DEFINITION  Bacillus sp. FDAARGOS_1420 tig00000008_trim_arrow_pilon, whole
            genome shotgun sequence.
ACCESSION   NZ_JAHWJB010000003
VERSION     NZ_JAHWJB010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. FDAARGOS_1420
  ORGANISM  Bacillus sp. FDAARGOS_1420
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 506737)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 506737)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2021) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, White
            Oak, MD 20903, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 2.1.1
            Genome Coverage                   :: 1241.19x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019344915.1-RS_2024_09_12
            Annotation Date                   :: 09/12/2024 05:20:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,050
            CDSs (total)                      :: 6,900
            Genes (coding)                    :: 6,426
            CDSs (with protein)               :: 6,426
            Genes (RNA)                       :: 150
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 109
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 474
            CDSs (without protein)            :: 474
            Pseudo Genes (ambiguous residues) :: 0 of 474
            Pseudo Genes (frameshifted)       :: 199 of 474
            Pseudo Genes (incomplete)         :: 296 of 474
            Pseudo Genes (internal stop)      :: 116 of 474
            Pseudo Genes (multiple problems)  :: 119 of 474
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:39:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 64781
            Orig. end                         :: 91349
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHWJB010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26568
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26568
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26568
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16568](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16568
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            111..1820
                     /locus_tag="I6L50_RS29370"
                     /old_locus_tag="I6L50_29350"
     CDS             111..1820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016514214.1"
                     /locus_tag="I6L50_RS29370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29350"
                     /product="hypothetical protein"
                     /protein_id="WP_219303799.1"
                     /transl_table=11
                     /translation="MEKPFVIKNKRSLNGETTTPVIVTIKSWQKLVEALEGRYYSFKDT
                     YLEDIVKSMSYEERIADEEGFVEQAKPSFSLKMKKVLDKVSVFDKNEGRKHKLYGITNA
                     DLEVFLFLYKKCNTYGELSHVSIHMLWEDYKNYKEAFAHIHHSQFYVALKKLSFHNIIT
                     IENEYSGKYKIILTDFMNKETNKANAYTFISPIVFTKEFFELSIAAKKLFMDVAMQQKR
                     ETTLKRSLFKVDEQGNSTHFGGMYRYLHKKYPHQIRAVLEELETKLSATGSPLFKICKL
                     EKGKRNKKQYTTLHLSVHPDFLCAKEEGAEYRDPFTPRDTYKRKVKFIENLLVEMNIAE
                     FAKDMNQFINVLKHSCHRQIRQVVRGLREIIDRQEGYPKKLVYTLSKLLKQSSQYRVLD
                     TAAKTGIYPLITHNVPKHEQEEAIFKFGTHFAIYSLRNVQKLFRKAHDLLHAKYAVPVT
                     IDAYHRNYMQYQEESLFRKYAYEQGVNINAYTALEIEIRELLKSSGHKGNQIPSDIREL
                     FIEKIDKLPKEKIRVIEVAEDFDLIQFLQSLEAYYRSTSEVPHTVDQLLPAM"
     misc_feature    complement(2265..2278)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.73"
                     /tool="antismash"
     gene            <2763..3128
                     /locus_tag="I6L50_RS29375"
                     /old_locus_tag="I6L50_29355"
                     /pseudo=""
     CDS             <2763..3128
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000447866.1"
                     /locus_tag="I6L50_RS29375"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29355"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEITGVKVKNKKARALELLEKVGLTEVEAKRNVLQLSGGQQQRVA
                     IARALSCNVDLLIADEPTGNLDGETANEIIELFQELAHQEDKCVIVVTHSQEVAKKSDR
                     AVYLRKKKLVVNEINNI"
     gene            3380..>3463
                     /locus_tag="I6L50_RS29380"
                     /old_locus_tag="I6L50_29360"
                     /pseudo=""
     CDS             3380..>3463
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470156.1"
                     /locus_tag="I6L50_RS29380"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29360"
                     /product="N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNVKFCKKERFLIRKFEFKDWQAVHEYT"
     gene            3747..4223
                     /locus_tag="I6L50_RS29385"
                     /old_locus_tag="I6L50_29365"
     CDS             3747..4223
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016077702.1"
                     /locus_tag="I6L50_RS29385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29365"
                     /product="N-acetyltransferase"
                     /protein_id="WP_219303800.1"
                     /transl_table=11
                     /translation="MELNNWDGISIEKGTSINMEEMELLLLADPSTEVVNGYLKKGDCF
                     VLKKGAVTVGIMILIPTRTETIEIINIAVSEKEQGKGYGKYLLRFAIDYAKKEEYKTIE
                     IGTGNSSLMQLGLYQKCGFRITSVDKDFFLRNYNEEIYENGIQCMDMIRLTKNI"
     gene            4762..6036
                     /locus_tag="I6L50_RS29390"
                     /old_locus_tag="I6L50_29370"
     CDS             4762..6036
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002167131.1"
                     /locus_tag="I6L50_RS29390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29370"
                     /product="MFS transporter"
                     /protein_id="WP_219303801.1"
                     /transl_table=11
                     /translation="MRSTWKEFKGMDLNVWIRFIGEALNGIAMMMLMPFFALYLKDKVD
                     SLLEVGVIIALSPIAASIGSLIGGHIADTYGRKPTMVLSMASNGLLMLFFLFIDGFIAY
                     AILSIGLGLCNSFFEPAASAMVTDVTEPEKRTEAYGLLRMAHNIGAAIGPIIGAAVVDV
                     SKDVIFLITSGTMLFYTILMVLFLKETKPKNVMIHEEPPGNSIRSTLRVVIRDRILLFY
                     IVTGIIIFMGFSQSEGMLPLHFSNEKTIIFGNSNPFPYLMTLNGLLVVFFQFPISKWLT
                     HKSIGKSMLYGAILFGIGLLAIGWLPKWFQVINTNDLVILVSLLIAYTVYTLGEMIMSP
                     VQMTFVANLAPEHLRGTYMGAANLQWITGNILGPLLGGLLLEHLLGHILFTILGVGCVM
                     SGFVYLLLDKLVENRSKQIPIKQTS"
     gene            complement(6216..6683)
                     /locus_tag="I6L50_RS29395"
                     /old_locus_tag="I6L50_29375"
     CDS             complement(6216..6683)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016107592.1"
                     /locus_tag="I6L50_RS29395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29375"
                     /product="RsfA family transcriptional regulator"
                     /protein_id="WP_219303802.1"
                     /transl_table=11
                     /translation="MIISRQDSWTIDNDLLLATIVLQNIRNGGTQLAAFKKVAKQLTRT
                     SAACGFRWNSYVRKQYTEEIKQAKQNRKLGNTISPSKQKKEANSLSITLDDIIIFLQNY
                     KEVNELTNLQQQIEYLEAENKSLLQRLTTYEEEYRMLINHIDKTRNLIVVD"
     gene            <6754..7701
                     /locus_tag="I6L50_RS29400"
                     /old_locus_tag="I6L50_29380"
                     /pseudo=""
     CDS             <6754..7701
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688773.1"
                     /locus_tag="I6L50_RS29400"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29380"
                     /product="S8 family serine peptidase"
                     /pseudo=""
                     /sec_met_domain="Peptidase_S8 (E-value: 2.2e-18, bitscore:
                     61.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKGGDGKGTTFVDMEYGWLFNHDHGTSVLGIVSAENNNIGGIGIA
                     PKAKVKVVSQIRDNSRYNTADAILSAVNNMQAGDILLLEAQATYDGYGNKNYLPVEVKR
                     DIFDAIRMGTSKGSIIIEAGANGGNDLDQFRDRNGKQVLNRNSPDFKDSGGIMVGAASA
                     RVPHKRSSFSNYGNRVDVYGGGNAVDTTGAKPNQFMTNPYTYSFSGTSSASLIIAGGAA
                     SIQGITKTNRRKVYTPSQLRDILSDPISDKLGVLPDLKAIISKLGFSPNLSNDSSIVFP
                     EEQEINKGNEGATITFPGEDSANSEGNSNFIFLE"
     gene            complement(<8082..8185)
                     /locus_tag="I6L50_RS35875"
                     /pseudo=""
     CDS             complement(<8082..8185)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096890.1"
                     /locus_tag="I6L50_RS35875"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="RsfA family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVLQNIRDGRTQVATWLEHLLLADFVGTLTHEKN"
     gene            8940..9113
                     /locus_tag="I6L50_RS29405"
                     /old_locus_tag="I6L50_29385"
     CDS             8940..9113
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429839.1"
                     /locus_tag="I6L50_RS29405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29385"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_219303803.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.3e-13, bitscore:
                     44.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNLFDLDLKVEKSSNGVEPRITSVAFCTPGTCACEDGPTFNSA
                     CCSVEFTIYNCK"
     misc_feature    complement(9230..9245)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.24"
                     /tool="antismash"
     gene            9239..9412
                     /locus_tag="I6L50_RS29410"
                     /old_locus_tag="I6L50_29390"
     CDS             9239..9412
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429839.1"
                     /locus_tag="I6L50_RS29410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29390"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_219303804.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.3e-11, bitscore:
                     37.9, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNLFDLDLKVEKSSNGVEPRITSVAFCTPGTCACEDGPTFDSA
                     CCSVEFTIYNCK"
     gene            9515..9724
                     /locus_tag="I6L50_RS29415"
                     /old_locus_tag="I6L50_29395"
     CDS             9515..9724
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014145.5"
                     /locus_tag="I6L50_RS29415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29395"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_257475450.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.2e-12, bitscore:
                     41.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLNNYTEVRKMENNLFDLDLKVEKSSNGVEPRITSVALCTPGTC
                     ACNDGPTFDSACCSVELTVYYCTR"
     CDS_motif       9515..9613
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNLNNYTEVRKMENNLFDLDLKVEKSSNGVEPR"
                     /locus_tag="I6L50_RS29415_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9614..9724
                     /prepeptide="core"
                     /locus_tag="I6L50_RS29415_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="16.70"
                     /molecular_weight="3604.1"
                     /monoisotopic_mass="3601.6"
                     /core_sequence="ITSVALCTPGTCACNDGPTFDSACCSVELTVYYCTR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLNNYTEVRKMENNLFDLDLKVEKSSNGVEPR"
                     /leader_location="[9514:9613](+)"
                     /alternative_weights="3622.1"
                     /alternative_weights="3640.1"
                     /alternative_weights="3658.1"
     gene            10001..13192
                     /locus_tag="I6L50_RS29420"
                     /old_locus_tag="I6L50_29400"
     CDS             10001..13192
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="I6L50_RS29420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29400"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_219303805.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.4e-149,
                     bitscore: 492.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.4e-11,
                     bitscore: 37.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.3e-39, bitscore:
                     129.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLYTPLDFFLLRTPTYSIDNFKSIIDIGSEEESLDYILNNVLS
                     NEKIIEMLIVASPKLYEALLRLENDPNTKKKEQIILNLTKYLIRMSTRSTPFGLFSGVS
                     IGDFDDKTGIQIDDINHFTKTARPDMAWLLGFIKQIESDIDNVKHLKVMVNHLTVVSGS
                     RANLLYSTQYGERSKATKKEVVASSIKYNEVSQKVFDRAQEPILFSNLINSIKLEYPNV
                     QEETIAQFVWNLFKNEYLISELRPILTNGNPFEYVINKLSEKEALTKYYVQLTKLKEDI
                     DIYNGLSLGEGKELLLNLFDSMKRIYEVDTPLQVDLSIKTKHSTLSKSIQNELSKVADF
                     LWVLTPKKNNNNELDHYRNDFLEKYGEYREISILELLNPDIGLGAPGGYLNPPSYKKVE
                     NPPVNQLNEFENYLLEEISRLSCSNNGDIREINVENKIYEKFKKKDMDLNTAAVSMELY
                     FRIISESSSNIDNEQYQIQLVPNAGSDGAGKTFGRFNQLFNEENQEKLYKINQLEKLFY
                     EDTIFAEMVYLPDYGRSANVTISNNIRDYELCIGTNSSKDKKQTLSMSDLVVGVYQGNF
                     YIRSKSLNKRVIITTGHMLNIAGCHNLCRLLKELSNHGMVHWKLPIFSWMTKMAFVPRI
                     NLGKVTIIPAMWNLNLNMLDINVKELKKDFELFKKQFHKWCAEYKVPRFIYLFDMDNRI
                     LIDTKNNLHVKIIQKEMSSSKGNKVQFYEMGNEISKEWIEGDTGTYISEVVVPFIKNQE
                     VVEEKMKVHFNASHSIECNQVRTKEPGSDWLYFRIYCNNNMEDEFIGQELQLICNNAVF
                     EGLADKYFFMRYSDNKKHIRLRFNMSNKDNFPKLISYINTHCNQLKEKGVVSSVAIDVY
                     EREVERYGGPELIGEAEDLFFLDSQFVQELIRLKENNLLNTSFENICIYSILDYLQGFE
                     LTHEEQLKLMEAVVDYKEYLEDFRKGKKVLVNLCNKNNVIDFGITTDNSDLYELLAARK
                     KQIKLYKEKIDAIEIQGKLFNVRENIILSVIHLHCNRLIGIDRVYEKKLNTLARHTLKA
                     LSYFYEKQNKILITH"
     aSDomain        10454..10738
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I6L50_RS29420_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.90E-12"
                     /identifier="RREFam001.1"
                     /label="I6L50_RS29420"
                     /locus_tag="I6L50_RS29420"
                     /protein_end="246"
                     /protein_start="151"
                     /score="37.7"
                     /tool="antismash"
                     /translation="VMVNHLTVVSGSRANLLYSTQYGERSKATKKEVVASSIKYNEVSQ
                     KVFDRAQEPILFSNLINSIKLEYPNVQEETIAQFVWNLFKNEYLISELRP"
     gene            13344..15158
                     /locus_tag="I6L50_RS29425"
                     /old_locus_tag="I6L50_29405"
     CDS             13344..15158
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="I6L50_RS29425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29405"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219303806.1"
                     /transl_table=11
                     /translation="MKEMFKSTKYWLRTLKLLFEVNWFYMICIMAFAILQGILPVATLL
                     ITQELINTILASIGKSFDPVLFWFVLLATVSLVLVLVQIIQSYLQSVLQLLIVYKLNVK
                     LMKKSSELSLTDFENPEIYDKLQRAQGEVGTRPFQVFTTLLSIITGIITLLSSAVVLIT
                     WKWWVFLLLIITPIISTYYSLKIGKWEFDIQVQRTPKFRKSWYYSFLLTKDINYKEIKA
                     FNLGEYIVNRYKKIYDDFIVMDKKIARKKAVVGLIFSCLEEIIGLFITLFIIFVTFTGE
                     ILIGNLMGYMKAVGLCVTSFKGVFNSIASLLQNNLYIKQFFEFLDLETDMSVRKQDDYI
                     KLGNIKKIEFQNVSFKYPGSQKYALKNVSFTIKKGQIVGIVGENGSGKSTLTKLLLRLY
                     RVEEGTILINDQNINKYCEEDVRKRMSVVFQDYVKYELTVQDNIGLGNVKSLQNKERIL
                     QSAEKSGAKSMIDQFPEGINTQLGSWFAESQQLSGGQWQKIAVARSFFKPADIYILDEP
                     SAVLDPISEKHIFDKFFNVVEDKIGIFTSHRFSTIKIANEILVFDKGCLVEKGSHNQLV
                     EQNGYYSKLYGIQASPFNEENKKSYQLN"
     gene            15186..16568
                     /locus_tag="I6L50_RS29430"
                     /old_locus_tag="I6L50_29410"
     CDS             15186..16568
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="I6L50_RS29430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29410"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_219303807.1"
                     /sec_met_domain="LANC_like (E-value: 7.8e-73, bitscore:
                     240.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKVDEGEYISPLGDSEIKFEIERVILEITKRLKDPESVKGIVT
                     NKNNTMKFLEKDIIPWEDVSLSTGHPSLCLFLGELSENYPAEKWDVVAHNYVLQINEYL
                     SKNGMYSYSLFQGFTGIGFAVTALSKGATRYQNFIRQTNNLVIDYINRILPTYYKKLEE
                     NNLGMSDYDVISGVTGIGRYLLLYKDNEREQVALKHILNFLVKMTEDKLINNCLAPGWY
                     ISSENQYLDSEKELYPNGNFNLGLSHGIPGPLSLLSVSLKNGIEVEGQKEAIVKIADWL
                     IKFKIESDTGSFWSFRVDWDEFIAGEGKQNSASRAAWCYGTPGVARALYLAGKVTNNQE
                     YIDVSIQTLDNLFNYQRHEWGLYSPTFCHGYAGLLHILNLMYIDTKKEKFKGYILELLQ
                     MTLNTYDSNSPFGFYNYQLGKDKMELSVNIGLIEGVSGILLVLLALIKPIKTNWDTAFL
                     LN"
     gene            16772..18187
                     /locus_tag="I6L50_RS29435"
                     /old_locus_tag="I6L50_29415"
     CDS             16772..18187
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720068.1"
                     /locus_tag="I6L50_RS29435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29415"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_219303808.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-47, bitscore:
                     157.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIIVLIAIYFSIIGSFFVQGVTTFAQSDDHIYYTLLLKEGYST
                     DAFLDNLKINNNIVDITYTVPEIGLIQIQADKKRIEEIRRDPLVEEINPSIGIVNSRQI
                     SNDVTKLQMEPNKPSVWDLQWDVREVTHDGKSYEEFTGTHNVVVGIIDSGIDVNHPDLA
                     KNVLSGSKNLVPKGGYRGTEESETGDINYLDDKRGHGTHTAGLIAANGLMKGVAPGVGV
                     RAYRVFGGKSAEPIWIAKAIIEAAKDDVDVINLSLGSYLVNGTIYSKEGASTKEAAEIK
                     AYKKAIKYAKKQGSVVVAAAGNDGIDVTNYQMMDKLIKERLLQDDLTYKGKGLDVPASL
                     PGVITVGSTGPTQELSLFSNYGLGFSDLTAPGGDLRLFNKFGSDAYMKEGWFRKEQVIS
                     TRPRGGYYYGAGTSTAAPKVSGALALIIDKYKLKNSPNEATRDLYKYGVNKTPIDALFF
                     GKGKLDIYNAINH"
     gene            complement(18325..19110)
                     /locus_tag="I6L50_RS29440"
                     /old_locus_tag="I6L50_29420"
     CDS             complement(18325..19110)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I6L50_RS29440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="I6L50_29420"
                     /product="hypothetical protein"
                     /protein_id="WP_219303809.1"
                     /transl_table=11
                     /translation="MKKLISAEIQRIFARKSTIVLFLISILYPLIFFYLSQLRWKFDSY
                     VVNGIKLPLNNLNFPVGQILTYHILLIIIILPLFYSESLSSEVDSGAYKMILLRPFKKW
                     KTLVSKWISLIIVYAGMLLLTYLTNTLIGYMFMPKVEQANYYNIEEPMGLFASSIYNFK
                     FYFIIFIVHIALLSVVSFISVILKKPLLTFMGSIAFIVASIYLFDSIKNILFHTPDIAF
                     SILGGTYNFDYTFVIFILIMPLFFGTSLFIWNKRIGSMV"
     gene            complement(19257..20084)
                     /locus_tag="I6L50_RS29445"
                     /old_locus_tag="I6L50_29425"
     CDS             complement(19257..20084)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477082.1"
                     /locus_tag="I6L50_RS29445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29425"
                     /product="ABC transporter permease"
                     /protein_id="WP_219303810.1"
                     /transl_table=11
                     /translation="MFKSLFLYESEKFWSKKINILCFIAIPIIVLLSLKFAVQTNATLK
                     PLSVAFSSNLNFHLTSLQEMLFTAFNAIVITFCAISFHEEYKKGTLRIPFTRGISLKQL
                     YLAKSLIFMLNIFLILILQLLVSLIIGWLFLPKLTKIPLFFMNGLYGINEIIQYSFKYY
                     LLGYMSLLAFGSIVEFISLKLKTITGVIGLSLGFIFANILYIIVISPFIKGYPENHPVV
                     FTYQSLSLILTQVKGAAYFAAGVTNIFLYSPIVIFTVFKTLSYITFTRNDYLD"
     gene            complement(20146..20874)
                     /locus_tag="I6L50_RS29450"
                     /old_locus_tag="I6L50_29430"
     CDS             complement(20146..20874)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717865.1"
                     /locus_tag="I6L50_RS29450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219303811.1"
                     /transl_table=11
                     /translation="MKKIEVKHVNKTLNKRKIIHDATFDILEGDICGFIGPNGAGKTTL
                     MKIITGLIKPDEGSVYNNGIDVLKNRELALNGIGAIIEIPVFFEYMSGRKNLQNLARLN
                     TNMNRKEQLAKVEEVLEIVDLKDRGDDKVKGYSLGMKQRLGIAQALLNNPTIVILDEPA
                     NGLDPMGMRDLRELILNLRKNLGITFFISSHLLDELQKICNKYVFIREGKIKWTGDSHV
                     LMSSVGDEKKLEAVFMELMS"
     misc_feature    complement(21008..21022)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 24.01"
                     /tool="antismash"
     gene            21241..21924
                     /locus_tag="I6L50_RS29455"
                     /old_locus_tag="I6L50_29435"
     CDS             21241..21924
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376128.1"
                     /locus_tag="I6L50_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29435"
                     /product="response regulator transcription factor"
                     /protein_id="WP_219303812.1"
                     /transl_table=11
                     /translation="MDRRVLIVDDNIEIISFVKPALEVEGYTVDYAVSGDEALQKINLD
                     FDIILLDVTLPDTSGFDICKNIRRKVDCPILFLTARGLEQERIKGFLVGGDDYIVKPFS
                     LKELILRMSVHIRKDKRESSSKKSNELIFGDLRVNILSKSIQINKQIVELTRKEYEIIE
                     LLCTHSGQVFSKEQIFEVVWGNISDSNITTVTEHVRRIRLKLHYCGLKKVCIKTVWGLG
                     YKWEC"
     gene            21918..23387
                     /locus_tag="I6L50_RS29460"
                     /old_locus_tag="I6L50_29440"
     CDS             21918..23387
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000525615.1"
                     /locus_tag="I6L50_RS29460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29440"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_257475423.1"
                     /transl_table=11
                     /translation="MLKRLNMRLKIKTQFVLYFLLCFMVSVIMSLLFLGIALFVFENKK
                     VADAIENYAVINSDKILNVNFQDELNKQIPKNDFEYWIVSNNKKVLYTSTNMKKLPENL
                     TIISKEYYGKEYNNATYGISFKPLFSEGKFKGGIVLRYKSNVFVESSIINTLIKKFKYN
                     VFLFFFILFPIFIICPFIIILIFSVLFSKEIVRPLKEMVRLSNHIKIGRLDFIIDTSYT
                     NELGQVLKSFEDMRIALQKSLKAQWIMEEQRKDMILSLTHDIKTPITIINGHLELLAGS
                     YNHISEENRKAYINIMLSNSEKIKKMINELNEIWDLERPNFKLDFQKVDLNDYILELEG
                     DYIYICAKKNVNFRIIDSLPPREKFDFDSFRINEVLQNIITNSLKHTDDKGEILLEIYL
                     ENGNLTFRVSDNGKGFSEEVDLVFNKYYKGNGDLIYKNSSGLGLYICKIIIEKHGGEIS
                     ACNNKRGGATIEFSLPGNNKLKEDDECSDIV"
     gene            complement(23488..>23694)
                     /locus_tag="I6L50_RS29465"
                     /old_locus_tag="I6L50_29445"
                     /pseudo=""
     CDS             complement(23488..>23694)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016090861.1"
                     /locus_tag="I6L50_RS29465"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="I6L50_29445"
                     /product="zinc ribbon domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LIFVSKTFASSQSYSCCGYQNKDVKNLNLLK"
     gene            24028..24435
                     /locus_tag="I6L50_RS29470"
                     /old_locus_tag="I6L50_29450"
     CDS             24028..24435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016136174.1"
                     /locus_tag="I6L50_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29450"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_016093855.1"
                     /transl_table=11
                     /translation="MIFQSMITAIIEKLQETVNPYWIIVFGSTAENREREDSDIDIAYL
                     SDTTLGNYERFLLAQELANIVNRDVDLVDLSEASTVFQAQIIHTGKTIFCSDDKRKVVF
                     EMKTLKMYSKLNEERQVVFDDIKKRGSIYEE"
     misc_feature    complement(24056..24072)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.92"
                     /tool="antismash"
     gene            24425..24838
                     /locus_tag="I6L50_RS29475"
                     /old_locus_tag="I6L50_29455"
     CDS             24425..24838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002175020.1"
                     /locus_tag="I6L50_RS29475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29455"
                     /product="DUF86 domain-containing protein"
                     /protein_id="WP_219303814.1"
                     /transl_table=11
                     /translation="MKNEVILNKISTIERCIKRIQDVYGNAPGNLEDFTKQDSIILNIQ
                     RACEASIDLAMHIVAGKKLGLPQSSREAFDLLVTAGLLSADLANKLKAMVGFRNIAVHD
                     YQSVNLDIVRQIIEKHLTDFKLFTKEVMGILEF"
     gene            <24973..25059
                     /locus_tag="I6L50_RS35880"
                     /pseudo=""
     CDS             <24973..25059
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096886.1"
                     /locus_tag="I6L50_RS35880"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="chemotaxis protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VQDIAGLENSLKWLSQELQELIGEFKNK"
     gene            25219..25434
                     /locus_tag="I6L50_RS29480"
                     /old_locus_tag="I6L50_29460"
     CDS             25219..25434
                     /GO_function="GO:0003690 - double-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001167046.1"
                     /locus_tag="I6L50_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29460"
                     /product="alpha/beta-type small acid-soluble spore protein"
                     /protein_id="WP_219303815.1"
                     /transl_table=11
                     /translation="MQIRENNNSNEIVIAAAASAIEQMKYEIAQEFGVTLGPDSTARAN
                     GSVGGEITKRLVRMAQEQLSGQYKIH"
     gene            complement(25510..25923)
                     /locus_tag="I6L50_RS29485"
                     /old_locus_tag="I6L50_29465"
     CDS             complement(25510..25923)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016107601.1"
                     /locus_tag="I6L50_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_29465"
                     /product="hypothetical protein"
                     /protein_id="WP_098717920.1"
                     /transl_table=11
                     /translation="MKKVILAGALGIAVLSGMNLPGAEAPKASAATTNLEIQEVTKYYS
                     MSSYEVSQKESFNLNKGEELTVFVQNSGFPISYTVFDADDQVIGTYNANSPYGRVFKAQ
                     KDGNISVQFQAGVNSSYMKKMNFTAKFAVSKFN"
     misc_feature    complement(25968..25980)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    26003..26021
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.68"
                     /tool="antismash"
     misc_feature    complement(26006..26021)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
ORIGIN
        1 cctcttaaag ggacagattt caccagcatt cgatttgata taatcaaaaa tgtaattcta
       61 tacctaattg tggggaaaac tgcaacttaa aataaaagga ggtgaaaaag atggaaaaac
      121 ctttcgttat aaagaacaaa cgtagtttga atggtgaaac aacaacaccg gtaattgtaa
      181 caattaaatc atggcaaaag ttagtagaag ctttggaagg taggtattac agttttaaag
      241 atacttattt agaagacatt gtgaagtcaa tgtcctatga agaacgaatt gcagatgaag
      301 aggggtttgt tgaacaagca aagccatctt tttcactgaa aatgaaaaaa gttttagata
      361 aagtaagtgt atttgataaa aatgagggca gaaaacataa gctatatggt attacaaatg
      421 ctgatttaga agtatttcta tttctttata aaaaatgtaa tacatatggt gagctttcgc
      481 atgtatcgat ccacatgctt tgggaagatt ataaaaatta taaagaagca tttgcacata
      541 ttcaccactc acaattttat gtggctttga agaagttaag tttccataac atcattacaa
      601 tcgaaaatga gtacagtggt aaatataaaa tcatcttaac tgatttcatg aataaggaaa
      661 cgaataaagc aaatgcatat acatttatta gcccgatagt atttaccaaa gaattctttg
      721 agttatccat tgcagctaag aaactattca tggatgtagc aatgcagcag aaacgcgaaa
      781 ctaccctgaa acgttcttta ttcaaagttg atgaacaagg aaactcaaca cactttggtg
      841 gtatgtatcg ttacttacat aagaaatacc cacatcagat tcgtgctgta cttgaggaat
      901 tagaaacaaa actttctgct actggatctc ctttatttaa aatttgcaag ttagaaaaag
      961 ggaagaggaa taaaaagcaa tacacaacat tgcatttatc tgtacatcct gatttcttat
     1021 gcgcgaaaga agaaggagca gaataccgtg atccatttac accacgagat acatataagc
     1081 gtaaagttaa attcattgag aacttgttag ttgaaatgaa tattgctgaa tttgcaaagg
     1141 atatgaacca attcattaac gttttaaaac actcttgtca tcgtcaaatt cgccaagtag
     1201 ttcgtggatt acgagaaata attgatcgac aagaaggata tccgaaaaag cttgtttata
     1261 cactaagtaa attattaaag caatcttctc aatatcgtgt attagacaca gccgctaaaa
     1321 ctggtattta tcctttaatt acacacaatg taccaaagca tgaacaagaa gaggccattt
     1381 ttaaatttgg tactcatttt gctatatact ctttacgcaa tgttcaaaag ttattccgga
     1441 aggcgcatga cctgcttcat gcgaaatatg ctgtacctgt aaccatagat gcttatcacc
     1501 gtaattacat gcagtatcaa gaggaatcac tatttaggaa atatgcttat gagcaaggag
     1561 taaatattaa cgcatataca gcattagaaa ttgaaattcg cgaactatta aaatctagtg
     1621 ggcataaagg aaatcaaatc cctagcgata ttcgtgaact gttcattgaa aaaattgata
     1681 aattgccgaa ggaaaagatt cgtgtaattg aggtcgctga agactttgat ttaattcagt
     1741 ttctacagtc cttagaagca tattaccgtt caactagtga agtaccgcat acggtcgatc
     1801 agctgcttcc agcaatgtaa agataaagct ctctattttt gaaaaaacaa aagtggaggg
     1861 ctattcgtat tggagataac atgtggaatg cattacttca aacaaaacag agagaaagtt
     1921 ttcaatctta atgattacga ctctctattt tttatgcaat tacatacatt gcacgtgaaa
     1981 caaaatgaga tattcacaat tttcgagttg aagaatctga atttttattt ttttatgcca
     2041 tttcatctat aaaaaagcat aaatattttt tattattctg ttgatatctt aataattttg
     2101 tcctgatgtg tataatagaa agctttaagt actgttctta tcatgttcta tctctaaatc
     2161 tacttaaaat cagaaaaaat tctgttagtt atgtttaaaa agtggattct gttcctaact
     2221 atgaccaatt tgttaataaa ttggtcatag tttttaagaa atgtggaaag tttgttcgta
     2281 agtcagcgaa atttgcattt attatttatt cattcactcg aatcaaatta acgatgatta
     2341 tatgtagatt ttatatgcct actttacgat attttgtagt ttttaatcat catccagctc
     2401 attaagtacg ttcccagtat ttacttttta tgattttttg cggctagagt aattatgaac
     2461 ccttagcaca gcactgtttt aacactattt tccctctgta taaaagtatt atcttttttc
     2521 tttatatatt aaagatatat attatattag gttttaatat tgtttaatgc ttactataga
     2581 gaataggtcc tgtgtaaaac caatttcatt tcttaatgga attagttctt ttatgtactg
     2641 taataaacat tttatttagt attaatcatt cctaaaaaac tttgatataa aatataaatt
     2701 ttttttatat tctcttagat ttccgaaaaa agtaaatcat acttaaagtg gatagttgat
     2761 taatggaaat tacaggtgtg aaggtaaaaa ataaaaaagc aagagcatta gaattattag
     2821 agaaggtagg actcacagaa gtagaagcga aacgaaatgt cttgcaacta agtggtggac
     2881 aacaacaacg tgtagcaatt gctcgagcac tatcttgcaa tgtcgattta ttgattgctg
     2941 atgaaccaac aggaaacctt gatggagaaa cagcaaatga aattattgag ttgtttcagg
     3001 agctcgctca tcaagaggat aaatgtgtaa ttgtagttac gcattcacaa gaagttgcaa
     3061 aaaaatcgga tcgagcagtt tatttaagga aaaagaagtt agtagtaaac gaaattaata
     3121 atatttaaga aaaaagctaa tttcgttctt aatacacgta attttcaaaa ttaaaattta
     3181 tggctgttaa tatttgttat ataatatatt tgtcaaagca ttacccctgt aatttctatg
     3241 atgaatctgt aagatagttt ttttgtctcg tatattcatc tgaaattaaa aagaacttgt
     3301 agagattcct acaagttctt tttgttttaa gggttaaatg tggatttgaa ataaagttac
     3361 gattttttga ggggagggaa taaatgtaaa attttgtaaa aaagagaggt ttttaatacg
     3421 aaaatttgag ttcaaagatt ggcaagctgt ccatgagtat acgccttcag gtggttttga
     3481 tgctacatgg caagaagaaa tgaaaaaaca gaaataaaat aacgtatata cctattatgt
     3541 ggattaattg gtaaatttat agtttctatc atattttatg atatttattc tataaaattc
     3601 gaaaagatga cagagtgttg gaaatccaag aggatttctc aacactctgt ctattactaa
     3661 atattaatat tgttgttgat attgtcttat aagaaggaat tcatttaaga tattaattga
     3721 aaatattaat tgggaggatg ttagaaatgg aattaaataa ttgggatgga attagtatag
     3781 aaaaaggtac aagtattaac atggaagaaa tggagttatt attactagct gatccctcaa
     3841 cagaagtagt taatgggtat cttaaaaagg gggattgttt tgttttaaaa aaaggtgctg
     3901 ttactgtggg tattatgatt ttaattccta ctcgaactga aacaattgag attataaata
     3961 tagcagtttc cgaaaaagag caaggaaaag gatatgggaa atatttactt agatttgcta
     4021 tagactatgc taaaaaagaa gaatataaaa ctatagaaat aggcacgggg aattctagtt
     4081 taatgcaatt aggcctttat caaaaatgtg gttttagaat aaccagtgtg gataaggact
     4141 ttttcttacg caattataat gaagaaatat atgaaaatgg tattcaatgt atggatatga
     4201 ttaggttaac gaaaaatata taaaaattat ttgtacataa aaatcgcaac gtccattaaa
     4261 tgtggagagt tgcgattttt tgatgtaatg cgtcattatg atttgtgggt attgacactc
     4321 ccacccctaa aggggccagc tgactaacgt cagtgggatt cttgctacca aaggcgaagt
     4381 ccatttctgg tatcgctgac gtgcaagatt gcggtgtgcc atcaccactc ccacaacaga
     4441 ccatataagt tcgtgggcta cggtactgtg accataccat acagattatt ggttctcaaa
     4501 tgtttttacg tcttttgcat gacgacttaa tacattttac ggagtagaag aatttgctac
     4561 cccaacctca tatgtattct gttttcagag aacagtcgtt ttagagtctt ttgcatgact
     4621 ataaataaag tatactatgt tttgctatgc aaaaacgctg ctttcatccc acgtctaaag
     4681 acggactaaa gtcctgcgtg ggctttcacg cttcataaat tctgtaataa aaaatataca
     4741 gtgagcatag gtgagatata tatgagaagt acatggaaag agttcaaggg gatggacctt
     4801 aatgtatgga ttcgctttat tggagaagct ttaaatggta ttgcaatgat gatgttaatg
     4861 ccatttttcg cattatattt aaaggataaa gtagattctt tgcttgaggt aggtgtgatc
     4921 atagctttat ctccaattgc agcaagtata ggctcgttaa ttggaggaca tatagcagat
     4981 acttatggcc ggaaaccaac tatggtactc tctatggcca gtaatgggtt attaatgctg
     5041 ttttttttgt tcatagatgg ttttatagca tatgcaatct tatctatcgg tttagggtta
     5101 tgtaactctt tttttgaacc agccgcatct gcaatggtta cggatgtaac agaaccagaa
     5161 aaaagaactg aggcatatgg attacttaga atggctcata atataggagc agcgataggt
     5221 cctataattg gcgcagcagt tgtagatgta tcaaaagatg tcatcttttt gattacttct
     5281 ggaaccatgc tgttttatac aatattaatg gtactgtttt taaaggaaac aaaacctaaa
     5341 aatgtcatga tacatgaaga accacctgga aattcaataa gatccacatt aagagttgtt
     5401 ataagggata ggatattact tttctatata gttacaggaa tcattatatt tatgggattc
     5461 tcgcaatcgg aaggtatgtt accgcttcat tttagtaatg agaagacaat aatttttgga
     5521 aatagtaatc catttccata tttaatgacg ttaaatggcc tattagttgt tttttttcaa
     5581 tttcccattt caaaatggtt aactcacaaa tcgattggga aatcaatgct atatggcgca
     5641 attctttttg gtattggtct tttggcaata ggatggttac caaagtggtt tcaagtaata
     5701 aacacaaacg atttagttat tttagtttca ttattaatag cttatacagt ttatacttta
     5761 ggagaaatga ttatgtcacc cgtccaaatg actttcgttg ctaatttagc tccagaacat
     5821 ttgaggggta cttatatggg agccgctaac ctgcagtgga ttacaggtaa tatattaggg
     5881 ccccttttag gcggtttatt actggagcat cttctagggc atatattatt tacaatctta
     5941 ggtgtgggat gtgttatgtc tggatttgtt tacttattat tagataaact tgttgagaat
     6001 agaagtaaac agatacctat aaaacaaaca tcttaatttt aaaagtgtta tcaagttgaa
     6061 aaaaatttct attttatgaa ttaagtaaag cgcacgttta ttaacaataa acgtgcgctt
     6121 tgcttattat catttataat gtattgaaat taattcatac atagtaactt tgacaggcta
     6181 cggttttaat atgataaaaa ttaatttgat tcttcttagt cgactacaat cagatttctt
     6241 gtcttatcga tatggttaat taacatacga tactcttctt cgtatgtagt taaccgttgg
     6301 agaagggatt tattctctgc ttctaaatat tcaatttgct gttgtaaatt tgtcaattca
     6361 ttcacttctt tataattttg tagaaagata ataatgtcat ctaatgtaat agataaagag
     6421 tttgcttctt ttttttgttt ggagggggat atggtgtttc ccaacttcct attttgtttt
     6481 gcctgtttaa tttcttctgt gtattgtttt cgcacgtatg agttccaacg aaatccacaa
     6541 gcagcagatg tcctagtcaa ttgtttagcc acttttttaa atgcagctaa ctgtgttccg
     6601 ccgttacgaa tattttgaag tactattgtt gcgagaagta aatcattatc aatagtccat
     6661 gaatcttgtc ttgaaattat catacttcaa tctcccttat atgtttttta ttacatatat
     6721 gcaattaatt aaagaaatag aagacgaacc ctccttaaag gtggagatgg aaaaggaacg
     6781 acttttgtag atatggagta tggctggtta ttcaatcatg atcatggtac ctctgtctta
     6841 gggattgttt ctgcagaaaa taataacata ggtggaattg ggattgcacc aaaagctaag
     6901 gtaaaggttg tgtctcagat tagagataac agtaggtata atacagctga tgctatatta
     6961 agtgcggtta acaatatgca agccggagat atacttttat tagaagcaca agcaacctac
     7021 gatggatatg gaaataagaa ttatcttcct gtagaagtaa aacgggatat ctttgatgca
     7081 attcgtatgg gaacaagtaa gggaagtatt atcattgaag caggtgcaaa cggcggaaat
     7141 gatttggatc aatttagaga ccgtaatggt aaacaagttt taaatcgtaa tagtcctgat
     7201 tttaaagatt cagggggaat tatggttgga gcagcttctg caagggttcc tcataaacgt
     7261 tcatctttct ctaattatgg taatagagtg gatgtatatg gaggggggaa tgcagtagat
     7321 acaacaggcg ctaaaccaaa tcaatttatg acaaatccgt atacatatag ctttagtgga
     7381 acgtctagtg catcacttat cattgctggt ggtgctgcat caattcaagg aattacaaaa
     7441 actaatcgta gaaaagtata tacaccaagc cagcttaggg atattttaag tgatccaatt
     7501 tctgataaac ttggtgtttt acctgactta aaagccatca tatctaaact tggtttttca
     7561 ccaaacttaa gtaatgattc ttccattgta tttcctgagg aacaagaaat aaataaaggg
     7621 aatgaaggag ctactattac attcccagga gaggattctg ctaatagtga agggaactct
     7681 aacttcattt tcctagaata atagaaatac ctcctattta gtatgaaaga acattatata
     7741 actggttgtt tataatacta gtgagatagg ctcttatgtg ttgtagcata agagcctatc
     7801 tattgtactt ttatctatat gaagaggaaa gtacttctgt ggatatttta tttgctgtaa
     7861 caaattgaaa ataaataaaa tatcacaata gacatattga aaaaagacat cttagggtgt
     7921 cctttttgct tttaaatatt taattttctt ttgttgattt tttgcatcat tcactttttt
     7981 ataatttttt agaaaaatta tagtgtcatc taatgtaata tatatagctt gttggatcgg
     8041 ggatttgttg tttccagcgt ttcaatttcg tttttcctgt tgtatttttt tcgtgcgtaa
     8101 gagttccaac gaaatccgca agcaacaggt gttctagcca agtagctact tgtgttctac
     8161 cgtcacgaat attctgaagt actattgtag taagaagtaa gtcattatca tcagtctatg
     8221 aatcttgtct taaacttacc atttttcaat ctcccttatg cgttttatat aaagagaatg
     8281 cagctgggtg actagaaata ccgtaagata tttagtgaaa atcctttaat ttatatttga
     8341 aagtaaaaaa gttaatttaa agattataga agaaatctaa ctttataata cctttcacga
     8401 aagtataaag taagtttatg taaaaactaa ctttatatta aaattatatt tcgtattgct
     8461 tttcacaagt ttaactattg tattcaaaaa taatttgtag gtaataaaga agatcaaatg
     8521 tataggaaat cagagtgcaa taatattgtt atattctaat taagtagtat ataacaatta
     8581 ttttagtaaa atcatatata aatatcgcaa tgtttttaat cctatctgca ttatttgtaa
     8641 atgattgtgg aacatttata tttattgatt ttttgatttt ttgatttttt gataaagtaa
     8701 aatatttgaa tgaagtaatg tatttcttat tttaaaatta atatgtctat taatctcaag
     8761 tttatgttgt atcaacagtg atactatcgt taattagatt aactaatttc gtgagttata
     8821 tctttgattt taaatatgca tttttacata aaaagtataa aaaacatttt tttaacattt
     8881 tgtattgaca atccaaatta tgggtataca atgaaatata gataaggagg tgagaaaaaa
     8941 tggaaaataa tttgtttgat ttggatttaa aagtagaaaa atcatcaaat ggtgttgagc
     9001 caagaattac aagtgttgcg ttctgtacac cagggacatg tgcatgtgaa gatggcccaa
     9061 catttaattc agcatgttgt agtgtagaat ttactattta caattgcaag taagaaagaa
     9121 tgtgaagtag tatctattag aaaaattaga tactagtaat tacataatat atttttgcaa
     9181 cggtttattt ttaataatcg gaatttttgt gcgaaaatat atagtggagg tgaaaaaaat
     9241 ggaaaacaat ttgtttgatt tggatttaaa agtagaaaaa tcatcaaatg gtgttgagcc
     9301 aagaattaca agtgttgcgt tctgtacacc agggacatgt gcatgtgaag atggtccaac
     9361 atttgattca gcatgttgta gtgtagagtt tactatttac aactgtaaat aaggataata
     9421 agttgcattt ataaatatct gataaatgag aaaaaattca ttattaatat ttaatctcgt
     9481 taaattaatt aagcggttat atttaattta aaaaatcaat ttaaacaatt atacggaggt
     9541 aaggaaaatg gaaaacaatt tatttgattt agacttaaaa gtagagaaat catcaaatgg
     9601 tgttgagcca agaattacaa gtgttgcatt atgtacacca ggaacatgtg catgtaatga
     9661 tggtccaaca tttgattcag catgttgcag tgttgaactt acagtttact attgtacaag
     9721 ataaataata aataggattt tctgtatcct aatgtttatt tcaaatgaac attaggatac
     9781 aaaattagaa attaatgtat gtagtctata tttaaataat ctcaaagtaa atgagattta
     9841 gagtattttt gagataagtc tatttataat gttataagtt tgaagagggt agtaaactat
     9901 atgtttaaaa aatttgagga atggaaaaac cgtttctcaa attttttaaa taaaggttta
     9961 tattgtgaca atacataaat atagggggat taaaagaaag atgaaatatt tatatacacc
    10021 attagatttt tttctgttac gtacacccac atattcaatt gataatttta aaagtattat
    10081 agatatcgga agtgaagagg agagtttaga ttatatatta aataatgttc ttagtaatga
    10141 aaaaataatt gaaatgctta ttgtggcaag tcccaaatta tatgaggcgc ttttaagatt
    10201 ggaaaatgat cctaatacta aaaagaaaga acaaattatt ctaaacttaa ctaaatattt
    10261 aataagaatg agtactagat caacaccgtt tggtctattt tctggtgtct ctataggtga
    10321 ttttgatgat aaaacgggta ttcaaataga tgatataaat cattttacta aaacagcccg
    10381 ccctgatatg gcatggttat tgggctttat aaaacaaatt gagtcggata ttgataatgt
    10441 taagcattta aaggtcatgg taaatcatct tactgtggtt tctggatcaa gagcaaattt
    10501 attatatagt acacagtacg gagaaaggtc taaggcaacg aaaaaggaag tagtagcatc
    10561 ttctatcaaa tataatgaag tttctcaaaa ggtttttgac agagcacagg aacctatatt
    10621 attttctaac ttaataaata gtatcaaatt agaatatccg aatgtccagg aggaaactat
    10681 agcacaattt gtatggaatt tgtttaaaaa tgagtattta ataagtgaac ttcgacctat
    10741 tttaacaaat ggaaatccat ttgagtatgt cattaataaa ttatctgaaa aagaagcact
    10801 taccaaatat tatgtacaac taactaagtt aaaagaagat atagatatat ataatggatt
    10861 atctttggga gaaggaaagg aattattgtt aaacctattt gatagcatga agagaatata
    10921 tgaagtggat acccctttac aagtagattt atcaataaaa acaaaacata gtactttaag
    10981 taagtctatt caaaatgaac tatcaaaagt agcagatttt ctttgggttc ttacacctaa
    11041 aaaaaataat aataatgagt tagaccatta tcgaaatgat ttcttagaga aatatggaga
    11101 atatagggag atttctatac tagagctact taatcctgat attggacttg gagcaccagg
    11161 aggatacctc aatccaccta gttataaaaa agtcgaaaat ccacctgtaa atcaattaaa
    11221 cgaatttgaa aattatcttt tagaggaaat atctagatta tcatgcagta ataatggaga
    11281 tattcgagaa attaatgtag aaaataaaat ttatgaaaaa ttcaaaaaga aagacatgga
    11341 tttaaataca gctgctgttt caatggaatt atattttaga attatttcag aaagttcttc
    11401 taatatagat aatgagcaat atcaaatcca gttagtacca aacgcaggat ctgatggtgc
    11461 aggtaaaacc tttggaaggt ttaatcaatt gtttaatgaa gaaaatcagg aaaaactata
    11521 taaaattaat cagctagaaa aattatttta tgaagataca atatttgcag aaatggtgta
    11581 tttaccagat tatggacgct cagcgaatgt tactattagt aacaatataa gggattatga
    11641 gttgtgtatt ggtacaaatt cttcaaaaga caaaaaacaa acactaagta tgtctgattt
    11701 agtagttgga gtatatcagg ggaatttcta tatacgatca aaatctctta ataagcgagt
    11761 cattattact acaggccaca tgctaaacat cgcaggatgt cataatcttt gtagactgct
    11821 aaaagaacta tcaaatcatg gtatggtgca ttggaagtta ccaattttta gttggatgac
    11881 aaagatggca tttgttccaa gaatcaattt agggaaggtt acaattatac ctgcaatgtg
    11941 gaatttaaat ttaaatatgt tagacattaa tgtgaaagaa ctaaaaaagg atttcgaact
    12001 ttttaaaaaa caatttcata agtggtgtgc agaatataaa gtacctagat ttatttatct
    12061 gtttgatatg gataacagaa ttttaataga tacaaaaaat aatctacacg taaaaataat
    12121 tcaaaaagaa atgtcttcct caaaaggcaa taaggttcaa ttttatgaga tgggaaatga
    12181 aatttctaaa gaatggatag aaggggacac tggcacgtat atttctgaag tagtagtgcc
    12241 atttattaaa aaccaagaag tagtagaaga aaaaatgaaa gttcatttta atgcgagtca
    12301 tagtatcgaa tgcaatcaag ttagaactaa ggaaccaggt agtgattggc tatattttag
    12361 aatttattgt aataacaaca tggaagatga gtttattggg caagaattac aattaatttg
    12421 taataatgca gtttttgagg gactagcaga taagtatttc tttatgagat attctgataa
    12481 taaaaaacac ataagattaa gatttaatat gtcaaacaaa gataatttcc caaaacttat
    12541 ctcttatatt aatacacatt gcaaccagtt aaaagaaaag ggagttgtat caagcgtagc
    12601 tattgatgtg tatgaaagag aagtagaaag atacggagga ccagagctta taggagaagc
    12661 ggaagattta ttcttccttg atagtcaatt tgtacaggag ttaataagac taaaagaaaa
    12721 taatttactt aatactagtt ttgaaaacat ttgtatttat agtatattag attatttgca
    12781 aggatttgaa ttaacccatg aggaacaatt aaagcttatg gaagctgttg tggattataa
    12841 ggaatattta gaggatttta gaaagggaaa aaaagtatta gtgaatctgt gtaataaaaa
    12901 taatgttatc gattttggaa ttacgacaga caattcagac ttatatgagt tattagcggc
    12961 taggaaaaaa cagattaaat tatataaaga aaagatagat gctatagaaa tacaaggaaa
    13021 attatttaat gtaagagaaa atattatact tagtgtaata catctacatt gtaataggtt
    13081 aataggtata gatagagtat atgaaaagaa attaaataca ttagcaagac ataccttaaa
    13141 ggctctaagt tatttttatg agaaacaaaa caaaattttg ataacacact aatggaataa
    13201 taaatttaag aacagaactc aattattata ataattgagt tctgttctta aaaaaaattc
    13261 ggtttttaga aaatatacat aacagtatta taggctaaga tatataatcc aaattcatga
    13321 tgaggaagaa tataggtgag aaaatgaaag aaatgtttaa atccacgaaa tattggctaa
    13381 gaaccctaaa gttacttttt gaagtaaatt ggttttatat gatttgtata atggctttcg
    13441 cgatattaca aggtatctta cctgttgcaa ctctcttaat aacacaagaa cttataaata
    13501 caatattagc atctataggg aaaagttttg atcctgtact attttggttt gtattattag
    13561 ctacagtttc attagtacta gtattagttc aaattataca aagttatttg caaagtgttt
    13621 tacagttatt aatagtatat aaattaaatg taaaacttat gaaaaaatca tctgagttat
    13681 cattaacaga ttttgaaaat ccggaaattt atgataaatt acagcgggca caaggagagg
    13741 ttggaactag accttttcaa gtattcacta cccttttaag cataattact ggaattatta
    13801 ctttattatc ctccgctgtt gtactgatta cttggaaatg gtgggtgttt ctacttttaa
    13861 tcataactcc aataatctct acttattatt ccttaaaaat tggtaaatgg gaatttgata
    13921 tccaagtaca aagaactcct aaatttagaa agtcatggta ctattcgttt ttattaacta
    13981 aagacattaa ttataaagaa ataaaagcat ttaaccttgg ggaatatatt gttaatagat
    14041 ataaaaaaat ttatgacgac tttatagtaa tggataaaaa aatagctaga aaaaaggctg
    14101 tagttggcct aatatttagt tgtcttgaag aaataatagg tctgtttata actttattta
    14161 ttatttttgt cacatttact ggagaaattt taatagggaa tttaatgggt tatatgaagg
    14221 cagtcggatt atgtgtaacg agttttaaag gtgtttttaa tagtattgcc tcattactac
    14281 agaacaattt atacataaag caattttttg aatttttaga tttagaaact gatatgtccg
    14341 tacgaaaaca agacgactat attaaattgg ggaacattaa aaaaattgaa ttccaaaatg
    14401 tttcctttaa atatccaggt tctcagaaat atgctttaaa gaatgttagt tttaccataa
    14461 aaaaaggaca aatcgtagga attgttggtg aaaatggttc agggaaatct acacttacaa
    14521 aactactact aagattatat cgtgttgagg aaggcacaat actgattaat gatcaaaata
    14581 taaataaata ctgtgaagaa gacgttagaa aaagaatgag tgttgtattt caggattatg
    14641 taaagtatga attaacagtt caagataata ttggattggg gaatgttaag agtctacaaa
    14701 ataaagaacg gatattacaa tcagcagaga agagtggggc taagagtatg atagaccaat
    14761 tccctgaagg aataaatact caattaggta gttggtttgc agaatctcaa caattatctg
    14821 gaggacagtg gcaaaagata gctgttgccc gttcgttttt taagccagca gatatctata
    14881 tattagatga acctagtgct gtacttgatc caatatctga aaaacatatt tttgataaat
    14941 ttttcaatgt tgtggaagat aaaataggaa tctttacgtc acatagattt tctacaatta
    15001 aaattgcaaa tgagattttg gtatttgata aagggtgttt agtagagaag ggtagtcata
    15061 atcagttggt tgaacaaaat ggatattata gcaaattata tggtatacaa gcatctccat
    15121 ttaacgaaga aaataaaaaa agttatcaac tgaattaaat ttaattttga gaggggtaaa
    15181 ataaattgat aaataaagta gacgaagggg agtatatttc tccattaggg gattcagaaa
    15241 ttaaatttga aattgaacgc gtcatattag aaataactaa aagattaaaa gatccagaaa
    15301 gtgtaaaggg aattgtaaca aataaaaata atacgatgaa atttttagaa aaagatataa
    15361 ttccatggga agatgtaagt ttaagtacag gccacccaag tctatgttta tttctgggtg
    15421 aattatcaga aaattatcca gcggaaaaat gggatgtagt tgctcataac tatgttttgc
    15481 aaattaatga atatctatct aaaaacggga tgtattcgta ctcacttttt caagggttta
    15541 ctggaattgg tttcgcggtt acagccttat caaaaggtgc tactcgatat cagaatttta
    15601 ttagacagac taataatcta gttatagatt atataaatag gattttacct acatattata
    15661 agaaattaga agaaaataat ttaggaatgt cagattatga tgtgatttct ggggtaacag
    15721 ggattggacg atacttactg ttatataaag acaatgaaag agagcaagta gctttaaaac
    15781 atatattaaa ttttttagtg aaaatgacag aggataaact tattaataat tgtctggctc
    15841 caggatggta tatttcttct gaaaatcagt acttagattc agaaaaggaa ttatatccaa
    15901 atgggaattt taatttaggg ctatcacatg gtattccagg tccactgtca ttactttctg
    15961 ttagtttaaa gaatggtatt gaagtagaag ggcaaaagga ggctattgtt aaaattgctg
    16021 attggctaat aaagtttaaa attgaatcag acacgggttc cttttggtca tttagggttg
    16081 attgggacga atttatcgct ggagaaggaa aacagaatag tgcgtcaagg gcagcctggt
    16141 gttatggaac tccaggggtt gcaagggcct tatatcttgc tggaaaggtt acaaataatc
    16201 aagaatatat agatgtttct attcaaacat tagataatct ttttaattat cagagacatg
    16261 aatgggggtt atattctcct acattctgtc atggatacgc tggacttctt catatactta
    16321 atttgatgta tattgataca aaaaaagaga agtttaaagg atatatttta gagttactgc
    16381 aaatgactct aaatacgtat gattcaaatt cgccttttgg tttttataat tatcaactag
    16441 gtaaggataa gatggagctt tcagtaaata tagggctaat tgagggagtt agtggtattc
    16501 ttttggtact attagcattg ataaaaccta taaaaacaaa ttgggataca gcatttttac
    16561 tgaattagtt taggtgtgaa taggtagtga tttagtatgc tagctaaatg aatatatgta
    16621 aatgattaat gtagtttgtt aatagaagat aatagtttaa gggaatatta aactattatc
    16681 ttttaatgtt gaactagaaa ttttcatttc atattagttg tttgaatttt taaagtggaa
    16741 atttctataa aatagttagg gatggtcatt aatgaaaaaa ataattgttt tgattgctat
    16801 atacttttcc ataattggaa gcttttttgt tcagggagtg actacttttg ctcagtctga
    16861 tgatcatatt tattataccc ttcttttaaa agaggggtat agcacagatg cttttttaga
    16921 taatttaaaa ataaataata atatagtaga tataacttat actgttcctg agattggact
    16981 tattcaaatt caggctgaca agaagcgaat agaagaaatc aggcgagatc cattagtgga
    17041 agaaattaat ccatcgattg gtattgttaa ctctagacaa atttcaaacg atgtaacaaa
    17101 attgcaaatg gaacctaaca aaccatcagt atgggattta caatgggatg taagggaagt
    17161 gactcatgat gggaaaagct atgaagaatt tacaggcact cataatgtag tagttggcat
    17221 tatagattca ggcatagatg ttaatcatcc tgatttagca aaaaatgtat tgagtgggtc
    17281 aaaaaattta gttcctaaag gtggatatag gggaacggaa gaaagtgaaa ctggcgatat
    17341 aaattattta gatgataaac gtggtcacgg cactcataca gcgggactta ttgctgcaaa
    17401 tggtttaatg aaaggggttg ctcctggtgt aggagtacga gcttataggg tctttggtgg
    17461 gaaatctgct gaaccaatct ggattgccaa ggcaattata gaagccgcta aagatgatgt
    17521 agatgttatt aatttaagtt taggttctta tctagtaaat ggtacgattt attcaaagga
    17581 aggagcatca acaaaagaag cagctgaaat caaagcatat aaaaaagcaa taaaatatgc
    17641 aaaaaaacaa ggaagcgttg tggttgcagc tgctgggaat gatggaattg atgttactaa
    17701 ttatcaaatg atggataaat tgataaaaga aagattatta caggatgatt taacatataa
    17761 aggtaagggc ctagatgttc cagcgagttt acccggtgtt attactgtgg gttctacggg
    17821 tcctacccaa gagttatcct tattttcaaa ttatggattg ggttttagtg atttaacagc
    17881 accaggtgga gatctaagat tatttaacaa attcggtagt gatgcatata tgaaagaggg
    17941 atggtttagg aaagagcaag ttattagtac acgtccaaga ggaggatatt attatggggc
    18001 aggtacttca accgcagctc ctaaagtttc cggagcattg gcattaatta ttgataagta
    18061 taaattaaaa aattctccta atgaggcaac tagagattta tataaatatg gagttaataa
    18121 aactccgata gatgctttat tttttggaaa gggaaagctg gatatctaca atgctataaa
    18181 tcattgattc ttagttaatg atttattata agacaaaata aaaggagcag gattgagagt
    18241 aaaaactcat cctactcctt ttattatttg tagatctaaa agttctttat tattaggcta
    18301 tcaggtggtt caaattgaaa ccatttatac catactgcca attcttttat tccaaatgaa
    18361 taatgatgtt ccaaaaaata agggcataat caagataaat ataacaaagg tataatcaaa
    18421 gttgtatgtt cctcccaaaa ttgaaaaggc aatatctgga gtgtgaaata gaatgttttt
    18481 tattgaatcg aataaataga tggaggctac tataaatgca atacttccca taaacgtaag
    18541 tagtggtttt tttaagataa cacttataaa tgaaactaca gaaagtaatg caatatggac
    18601 tataaaaata ataaaataaa atttaaaatt atatatactg gaagcaaata aacccatagg
    18661 ttcttctata ttataataat ttgcctgttc taccttaggc ataaacatat atccaatcaa
    18721 agtgtttgtt agatatgtta acaacaacat gcctgcatat acaattatta atgaaatcca
    18781 tttacttacg agtgttttcc actttttaaa aggtcgtagt aagatcatct tatatgcacc
    18841 tgaatcaact tctgaactta atgattcaga atagaataaa ggtaaaataa taattattaa
    18901 aagaatatgg taggtaagaa tttggccaac tggaaagttt aaattattca aagggagttt
    18961 tattccattt acaacataac tatcaaactt ccaacgaagt tgacttaaat aaaagaatat
    19021 aagtggatat aaaatagaaa ttaaaaataa aactattgta ctttttctag caaaaatcct
    19081 ttgaatttca gctgaaatta attttttcat agtatacacc ctctctatat agcgttaaat
    19141 aaaatcatta tttactttta gaaagtcata caaacaatgg gtaacataag tgtctgtaaa
    19201 gtttgtaggt ctaaaaaata tatttaataa cccttacgtt ttaatttgtt agcaatttaa
    19261 tcaagataat cgttacgtgt aaaagttata taagataaag ttttaaaaac tgtaaatata
    19321 acaattggac tgtataaaaa tatatttgta acgccagcag caaaataagc agcccctttg
    19381 acttgagtta atattagtga tagagattga taggtaaata caacaggatg attttctgga
    19441 tatcctttaa taaaaggact tatcactata atgtataaaa tattagcaaa tataaaacct
    19501 agacttaaac caatgacacc agtaattgtt ttaagtttca aggaaataaa ttcaacaata
    19561 ctaccaaaag caagtaaact catatatccc aataaatagt atttaaaaga atactgtata
    19621 atctcgttaa ttccgtaaag accattcata aaaaataaag ggattttagt taatttaggt
    19681 aagaataacc agcctataat taatgaaaca aggagttgca aaattaggat taagaaaata
    19741 tttaacataa aaattaaaga ttttgctaaa tataattgtt ttaaagaaat ccctcttgta
    19801 aacggaattc gtagagtgcc ttttttatat tcttcatgaa aacttatagc acaaaaagta
    19861 ataacaattg cattaaaagc agtaaagagc atttcctgta aacttgttaa atgaaagttt
    19921 aaatttgagc tgaatgctac acttaatggt ttgagtgtag cattcgtttg tacagcaaat
    19981 ttgagtgata gcaaaacgat aataggtata gcaataaaac atagtatatt tattttttta
    20041 gaccaaaact tttcagattc atataaaaat agagatttaa acattgaatc ctcctattac
    20101 tgatagatat attttcgatt agaatgtgtt aggtttattg agcctttaag acattaattc
    20161 cataaagaca gcctctaatt tcttttcatc acctactgaa ctcattagaa catgactatc
    20221 acctgtccat ttaattttac cctcgcgaat gaatacatat ttattacata ttttttgaag
    20281 ttcatctaga aggtgactgg agatgaaaaa agtaatccct aaattctttc taagattaag
    20341 aattaattcc cttaaatctc tcattcccat tggatcaaga ccatttgcag gttcatctaa
    20401 tatcactatt gttggattat taagtaatgc ttgagcaata ccaagtcttt gcttcatacc
    20461 caaagagtaa cctttaacct tatcatcgcc tctatctttt aaatcaacaa tttctagaac
    20521 ttcttcaacc tttgctaatt gttcttttct gttcatattg gtatttaatc gtgcaagatt
    20581 ttggagattt tttcttccag acatgtattc gaaaaataca ggaatttcaa taattgcccc
    20641 aattccgttt agggctaatt ctctattttt taatacatca ataccgttat tatatacact
    20701 gccttcatca ggttttatta atccggttat tattttcata agagtggttt tcccagcacc
    20761 atttggtcca ataaatccgc atatatctcc ttctaaaata tcaaaagtag catcatggat
    20821 tatttttctt ttattaagag ttttattaac atgtttcact tcaatttttt tcatctttta
    20881 tttcctttct tattaagaat cataataata tcatgggatg ttaagggggt aattgttctt
    20941 acacttatat ctaaacatat aaaaaacaac tctttatcaa ctttatttat ttttcttatt
    21001 ttcaatctaa aaatgaatat catgaatgag taatttaaaa tgattttgct cagaagaggt
    21061 atttattgta atatttatgt agccattata ttaaggatag tgaaatgaat aatcattttt
    21121 ataacaatat ttataaatat atacattaat tgattttgaa atggagtgaa tataagtaag
    21181 ctttataaag agttaagaaa agagtgtata taaagatatt acaaaagggt gatataagaa
    21241 atggatagac gagtacttat agtcgatgac aatatagaaa taatctcatt tgtaaaacca
    21301 gcacttgaag ttgaaggata tactgtagat tatgctgtat caggggatga agctttacaa
    21361 aaaattaatt tagattttga tattatacta ttggatgtaa cgttgccaga tacgagtgga
    21421 tttgatatat gtaaaaatat tagaaggaaa gttgattgtc cgattttgtt tttaacggca
    21481 agagggcttg agcaagaaag aatcaagggt tttttagttg ggggagatga ttatattgta
    21541 aaaccatttt cattaaaaga acttattctt agaatgagtg tacatataag aaaagataaa
    21601 agagaatcgt cctcaaaaaa atctaatgag ctaatcttcg gtgatcttag agttaatatt
    21661 ttatctaaaa gcattcaaat aaataaacaa atagtagagt tgactagaaa agaatatgaa
    21721 attattgagc tattatgtac gcactctgga caagtattct ctaaagaaca aatttttgaa
    21781 gttgtgtggg gaaatataag tgacagtaat ataactactg ttactgagca tgtaagaaga
    21841 atacgtttaa aacttcatta ttgtggactt aagaaagtgt gtataaaaac agtatgggga
    21901 ttgggatata aatgggaatg ttaaagcgtt taaatatgcg tctaaaaata aaaacacagt
    21961 ttgtattgta ctttctttta tgttttatgg tatcagttat catgtcattg ctatttttag
    22021 gtatagcttt atttgtattt gaaaataaga aggtcgcaga tgctattgaa aattatgcag
    22081 taattaatag tgataaaatt ttaaatgtga actttcaaga tgaattaaat aaacaaattc
    22141 ctaaaaatga tttcgaatat tggattgtat ctaataataa gaaggtgtta tatacttcaa
    22201 caaatatgaa aaaattacct gaaaatctta cgattatttc gaaggagtat tatggtaaag
    22261 aatataataa tgctacttat ggaatttcct ttaaaccttt gtttagcgaa ggcaaattta
    22321 aaggtggaat agttttaaga tataaaagca atgtttttgt agaatccagt attattaata
    22381 ctcttataaa aaaatttaaa tataatgtat ttttattctt ttttattctt tttcctatat
    22441 ttataatctg tccttttatt attatattaa ttttttctgt attattttca aaggagatag
    22501 tacgtccttt aaaggaaatg gttagattaa gtaatcacat aaagattgga cgattagatt
    22561 ttataattga cacgtcttat actaatgaat tagggcaggt tctaaaatca tttgaagata
    22621 tgaggatagc actgcaaaaa tcgctaaaag cacaatggat aatggaagag caaaggaaag
    22681 acatgatttt atcacttact catgatatta agacaccaat tactataatt aatggacatt
    22741 tagaattact cgcaggatcg tataatcata tttcagagga aaatagaaaa gcatatatta
    22801 atattatgct tagtaattct gaaaaaataa aaaaaatgat taatgaacta aatgaaatct
    22861 gggatttaga aagaccaaat tttaaattag attttcaaaa ggtagattta aatgactata
    22921 ttttagagct tgaaggggat tatatatata tatgtgcaaa aaagaatgtt aattttcgta
    22981 taatagattc attgccacct agagaaaaat ttgattttga ttcttttaga ataaatgagg
    23041 tactccaaaa tattataacg aactctttaa agcataccga tgataaggga gaaattcttc
    23101 ttgaaatata cttagagaat ggtaatttga catttcgggt gtcagataat gggaagggat
    23161 ttagtgaaga agtcgatttg gtttttaata aatattataa gggaaatgga gatttaatat
    23221 ataaaaatag ttctgggcta gggctttata tttgtaagat aattattgaa aaacatggag
    23281 gagaaatctc tgcgtgtaat aacaaaagag gaggagctac tatagagttt tctttacctg
    23341 gcaataataa gttaaaagaa gatgatgaat gtagtgatat tgtatagagg tgtacgatta
    23401 agaaaagaaa aaatattttg tacggtagat attcaatgct aatcattgat agttaatgcg
    23461 tcctaataat tagatagaag gaagggctta tgctaatgat tgtttaaaga taagcccttt
    23521 cttttttatt acttcatttt tcagattgat acttgcgtta atatccctat catgatgtgt
    23581 acgactagaa cggcagtctc atttaagtag gtttagattt ttaacgtctt tgttttgata
    23641 tccgcaacaa gaatatgatt ggcttgaagc aaatgtttta gatacgaaaa ttagaatgta
    23701 tattgaaata ggctaaagtc ctttagaatt gcaaaagtaa aaggttgaca gttattgtta
    23761 gtcttttact tttgtggaga gaaaatgtaa aaaacattta accagctaag tgttgaatta
    23821 taaacaatta tttaaggtcc aaaaccacaa catacttatt cctgaactat attaatatta
    23881 ggtcaggaat aagcttctaa ttttgtgagg agttaagtac taaaaactaa aaaggcttaa
    23941 ttttgtttaa gcatttgtag tagtttaaag gattttggaa tggttatgat ataataaaat
    24001 tcaattataa taagggggat taattaaatg atttttcaaa gcatgataac agctattata
    24061 gaaaaattac aagagacggt gaatccctat tggataattg tgtttggatc aacggctgag
    24121 aacagagaac gggaagatag tgatattgat atagcttatt taagtgacac aactttaggg
    24181 aactatgaac gttttttatt agcacaggag ttagcaaaca tcgttaatag agatgttgat
    24241 ttagttgatt tatccgaagc ttctacagtt tttcaagctc agattataca tacaggaaag
    24301 acaatatttt gttcggatga taaacgtaag gtcgtttttg aaatgaaaac cttaaaaatg
    24361 tattcaaaat tgaatgaaga acgacaggta gtatttgatg atataaagaa aagaggttca
    24421 atatatgaag aatgaggtta ttttaaataa aatttctaca atagagcgtt gtataaaaag
    24481 aatccaagat gtgtatggaa atgcccctgg aaatttagag gattttacaa aacaagattc
    24541 aataatattg aacatacaaa gagcttgtga agcgagtatt gatttagcga tgcatattgt
    24601 tgcaggaaaa aaattaggac taccccaatc tagtcgagaa gcctttgatt tgttggttac
    24661 agcaggatta cttagcgctg atctagcaaa taagttaaag gcgatggttg gatttcgtaa
    24721 tattgctgtt catgattatc aaagtgtaaa tttagatatt gttcgtcaaa ttattgaaaa
    24781 acatttaact gattttaaat tatttacgaa agaagtaatg gggatattgg aattttaggc
    24841 gaaagaacaa aataatagag ctgagaaaga aagtaattta taccagctat tgaaacaatt
    24901 acttaatttc gtaaaaagaa aagcggtcat aagatgaatt tgttcatgtt gaagtgaatc
    24961 tttgcatgaa atgtacaaga tattgcaggg ttggaaaatt ctttaaaatg gctctcccaa
    25021 gagttacagg agttaatagg ggaattcaaa aataagtagg ataggagaag gtatgggtat
    25081 gacctatacc tttatttatt cccacataag ggatgaaagc ttaggtatat atgtaaaata
    25141 gctaaaagaa tatttttttt gcatattttg ttggaaatag agcatgatat taccaaattc
    25201 aacggaggtg tttaaaaaat gcaaattcgc gaaaataata attcaaacga aatcgtaata
    25261 gcagctgcag caagtgcaat tgaacaaatg aaatatgaaa ttgcacagga gtttggtgtt
    25321 actcttgggc cggattcaac agcaagagca aatggttcag taggtggaga aattacaaaa
    25381 cgtttagttc gtatggcgca agagcagtta tctggtcaat ataaaattca ctaaagttaa
    25441 aggtatatcc catggaaggg atataccttt ttaatttgtc tttaaagagg atagtgaaaa
    25501 tttttactgc tagttaaatt tagacactgc aaatttggct gtgaaattca tcttcttcat
    25561 gtaagaagaa tttactcctg cttgaaattg aaccgaaata ttaccgtctt tttgtgcttt
    25621 gaatacgcga ccgtatggtg aattcgcatt gtatgtgcca attacttgat catctgcatc
    25681 aaagactgta taagaaattg ggaacccgga attttgtaca aagaccgtaa gttcttcccc
    25741 tttattaaga ttaaatgatt ctttttgaga aacctcatag gaactcatag agtaatattt
    25801 tgtaacttct tgaatttcta aatttgtagt tgctgcactc gctttaggtg cctctgctcc
    25861 tggtaagttc atacctgata gtactgcaat tcctaatgcc cctgctaaaa taactttttt
    25921 cataatgcta gttcctcctt taatatattg tgagatttga aaacgaagtg aaaatatcac
    25981 ctcttgaaac cattatagtt acaacgagaa tgattttcaa tgagatttaa tatgtaattt
    26041 tgcatacata agatgtcgat ataaggtaat ctatccgaag tttaaagtat tctaaagaag
    26101 tagagaacaa cttttcaaaa ctatgaatgt gatggtagct ggtttttaca tacgttggtt
    26161 ctataagtga atattttgtt gtttttttat tgtgcattca ttgtatgtaa ataaacaatc
    26221 aattgtttat aaagttttat aattcggaat tattaaacga aataagaggt tatatgttat
    26281 aataaagctg caataaggtt tagcatccta atcttattgt gtatatttag cctaagtatg
    26341 tcgtttgtat taaaaataag aagtctctca aaaagaggct tcttattttt ggtatggagg
    26401 gggattacag atgattgatt attatcaaat ttttttattt actatggcag gtattgcctt
    26461 gtttttttat atacaacatg ctagaaaacc aacgaaaaga aacaagtgga aattctttgt
    26521 tgtagtattt ttatttttcc ttttgaatta tttatttctt agatttat
//
