LOCUS       NZ_JAHWJB010000002     25239 bp    DNA     linear   CON 12-SEP-2024
DEFINITION  Bacillus sp. FDAARGOS_1420 tig00000007_arrow_pilon, whole genome
            shotgun sequence.
ACCESSION   NZ_JAHWJB010000002
VERSION     NZ_JAHWJB010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. FDAARGOS_1420
  ORGANISM  Bacillus sp. FDAARGOS_1420
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2021) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, White
            Oak, MD 20903, USA
REFERENCE   4  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2021) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, White
            Oak, MD 20903, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 2.1.1
            Genome Coverage                   :: 1241.19x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019344915.1-RS_2024_09_12
            Annotation Date                   :: 09/12/2024 05:20:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,050
            CDSs (total)                      :: 6,900
            Genes (coding)                    :: 6,426
            CDSs (with protein)               :: 6,426
            Genes (RNA)                       :: 150
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 109
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 474
            CDSs (without protein)            :: 474
            Pseudo Genes (ambiguous residues) :: 0 of 474
            Pseudo Genes (frameshifted)       :: 199 of 474
            Pseudo Genes (incomplete)         :: 296 of 474
            Pseudo Genes (internal stop)      :: 116 of 474
            Pseudo Genes (multiple problems)  :: 119 of 474
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:39:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1650254
            Orig. end                         :: 1675493
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHWJB010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="5"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    756..769
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            complement(968..1537)
                     /locus_tag="I6L50_RS18660"
                     /old_locus_tag="I6L50_18655"
     CDS             complement(968..1537)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="I6L50_RS18660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18655"
                     /product="hypothetical protein"
                     /protein_id="WP_002016999.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPSTSVFAAEKEAPIQQEETQMSI
                     QPFAQNNLETAVKAALNGPEVKKIKVFEHEFNVKPIEVVNLGGGKTYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFAAPLLSILAAYNGIPVNPNDLNALGQQ
                     IGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    1863..1876
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(1959..1973)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.9"
                     /tool="antismash"
     misc_feature    complement(1984..1999)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    2074..2092
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     gene            2137..2979
                     /locus_tag="I6L50_RS18665"
                     /old_locus_tag="I6L50_18660"
     CDS             2137..2979
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="I6L50_RS18665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18660"
                     /product="metallophosphoesterase"
                     /protein_id="WP_219302304.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.5e-09, bitscore:
                     35.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKTKRIILIIGILVGISIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKVKSINPDIIAITGDLIDSKSYDAEMSMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKKLKKQHVTVLRNEHVIIQKGGHEINLLGIDDPEF
                     NTGDIDEGSIVKDAIVKAKIETQPDRYNVLLSHRPEFLEEYAEEKVDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYEQQNTSMIVSRGLGNSIIPQRVFNRPEIVVVQLN"
     gene            3196..3447
                     /locus_tag="I6L50_RS18670"
                     /old_locus_tag="I6L50_18665"
     CDS             3196..3447
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="I6L50_RS18670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18665"
                     /product="hypothetical protein"
                     /protein_id="WP_002017002.1"
                     /transl_table=11
                     /translation="MHKEFEIEEYTAIEEQIHYYSTSLLVSHPEQIVKYLEKRLEKYAE
                     TLQYAHLYPETVILPIQQIVIEYSLDVARIRRYLNLKT"
     gene            3630..4355
                     /locus_tag="I6L50_RS18675"
                     /old_locus_tag="I6L50_18670"
     CDS             3630..4355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129461.1"
                     /locus_tag="I6L50_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18670"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002032219.1"
                     /transl_table=11
                     /translation="MQQPSIILRDVSKSFGKKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKMIAGINESTTGDVIVFNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKERIVEVFELVQLSEHMKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKSIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     QTSSGRIEDVFMLEGVIES"
     gene            4352..5371
                     /locus_tag="I6L50_RS18680"
                     /old_locus_tag="I6L50_18675"
     CDS             4352..5371
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="I6L50_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18675"
                     /product="ABC transporter permease"
                     /protein_id="WP_002085449.1"
                     /transl_table=11
                     /translation="MRVNGVVIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PHIAVVDVPAPIVKVMKNQEASIYEYSKDKAISELEKQKVDAVIHLENGKMNLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSMMKPEVDYLHGSKDITMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVLGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQVFFSGLFPMESMNTW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            5396..6049
                     /locus_tag="I6L50_RS18685"
                     /old_locus_tag="I6L50_18680"
     CDS             5396..6049
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="I6L50_RS18685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18680"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002065518.1"
                     /transl_table=11
                     /translation="MKKDWLEELVAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLFAVVMPTLTKFAAPFFVQAFAKEIFKTEYESYEVLL
                     RVIIQNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLIETELLVHFKKLIAKFQEEGE
                     IIELPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRR"
     gene            6054..7022
                     /locus_tag="I6L50_RS18690"
                     /old_locus_tag="I6L50_18685"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="I6L50_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18685"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_219302306.1"
                     /transl_table=11
                     /translation="MRQFAKPIIVVSKCLEFDACRYNGEMVPDLTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEKNGANMLVQPSIQEDVTEKMNEFSNAFLQTLPEVDGFILKN
                     RSPSCGTRDVKIYSGFEKGPIKGKGTGLFGGAVIKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVAFQSDYKYLFMAYNQVKQKELGRIIANQKNETMEVVFD
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLELIQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEGLVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="I6L50_RS18695"
                     /old_locus_tag="I6L50_18690"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="I6L50_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18690"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_002032227.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.7e-39, bitscore:
                     131.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.7e-26, bitscore:
                     89.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-57, bitscore:
                     192.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTLSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKFLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGFEDNGKKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKPISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERYIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="I6L50_RS18700"
                     /old_locus_tag="I6L50_18695"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="I6L50_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18695"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_002136442.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.9e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.5e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.1e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 3.3e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKLA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNIRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LKIALEELKVEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="I6L50_RS18705"
                     /old_locus_tag="I6L50_18700"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="I6L50_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18700"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001985297.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="I6L50_RS18710"
                     /old_locus_tag="I6L50_18705"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="I6L50_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18705"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_219302307.1"
                     /sec_met_domain="HMGL-like (E-value: 4.1e-49, bitscore:
                     165.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADASDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEISLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="I6L50_RS18715"
                     /old_locus_tag="I6L50_18710"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.1e-74. Score:
                     242.7. Matches aSDomain:
                     nrpspksdomains_I6L50_RS18715_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="I6L50_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18710"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_219302308.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRERQANSLSLALLEELQTILTQI
                     NEESNTRVVILTGDGEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIKIADRIANNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIDTKDRLEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6L50_RS18715_ECH.1"
                     /evalue="1.10E-74"
                     /label="I6L50_RS18715_ECH.1"
                     /locus_tag="I6L50_RS18715"
                     /protein_end="254"
                     /protein_start="14"
                     /score="242.7"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQTILTQINEESNTRVVILTGD
                     GEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIKIADRIANNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIDTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="I6L50_RS18720"
                     /old_locus_tag="I6L50_18715"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="I6L50_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18715"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_113936466.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLITPQEPKQFDKTLEEIIPENQNAPFNM
                     KDLINRIIDESSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYRLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="I6L50_RS18725"
                     /old_locus_tag="I6L50_18720"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 7.8e-82.
                     Score: 267.0. Matches aSDomain:
                     nrpspksdomains_I6L50_RS18725_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="I6L50_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18720"
                     /product="AMP-binding protein"
                     /protein_id="WP_113936465.1"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-88, bitscore:
                     292.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLFGWMKSLGYEDYEAFYNKSIEETAWFW
                     GEAERAVGYQWMKPYTEVLDLENGTPFAQWYTEGTCNVVESALSRWLADDKMKTQAALM
                     YEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFAADAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFRHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDRGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNNVIEAAAIGVPDDVKGEVCHCFVVLRDGVIFTAELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6L50_RS18725_AMP-binding.1"
                     /evalue="7.80E-82"
                     /label="I6L50_RS18725_AMP-binding.1"
                     /locus_tag="I6L50_RS18725"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QAALMYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFAADAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFRHAEEMNSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDRGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6L50_RS18725_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="I6L50_RS18725"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6L50_RS18725_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="I6L50_RS18725"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15681..15878)
                     /locus_tag="I6L50_RS18730"
                     /old_locus_tag="I6L50_18725"
     CDS             complement(15681..15878)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="I6L50_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18725"
                     /product="hypothetical protein"
                     /protein_id="WP_061690213.1"
                     /transl_table=11
                     /translation="MDKKNLLSQQLDYVSSDALNTPSKAQEQMQEASQEAHDSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            16302..16511
                     /locus_tag="I6L50_RS34940"
     CDS             16302..16511
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002032232.1"
                     /locus_tag="I6L50_RS34940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_374108427.1"
                     /transl_table=11
                     /translation="MHNGNSDVCQSRSEAVTVTVPGPLAARNTAVKLPEALVMTARGTM
                     KAREGLLNEKLTTTPGVGLPFTNT"
     misc_feature    16531..16548
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            16557..16760
                     /locus_tag="I6L50_RS34945"
     CDS             16557..16760
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254006.1"
                     /locus_tag="I6L50_RS34945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_257475401.1"
                     /transl_table=11
                     /translation="MVSLEVKVIDAGPAGRLNPVGPVGPVGPVGPVGPVGPVGPVGPVG
                     PVEPVEPVAPVAPVEPVGPVGN"
     gene            complement(<16778..16834)
                     /locus_tag="I6L50_RS35865"
                     /pseudo=""
     CDS             complement(<16778..16834)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="I6L50_RS35865"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLSFAALNPSSIGPTL"
     gene            complement(17032..17400)
                     /locus_tag="I6L50_RS18740"
                     /old_locus_tag="I6L50_18735"
     CDS             complement(17032..17400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="I6L50_RS18740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18735"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_219302309.1"
                     /transl_table=11
                     /translation="MGNIPKISSQQSNPKIPSQQVNPNTQQGHIKKTRRRIIITLAIIL
                     PIIFALQYSLNNQQEMIKEKQITLNTEQQKLSSVKKDGHSLKNDVKVLTGSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     misc_feature    17944..17957
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(17945..17958)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     15.94"
                     /tool="antismash"
     misc_feature    complement(18198..18211)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     strong, score: 26.74"
                     /tool="antismash"
     gene            18473..18829
                     /locus_tag="I6L50_RS18745"
                     /old_locus_tag="I6L50_18740"
     CDS             18473..18829
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="I6L50_RS18745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18740"
                     /product="hypothetical protein"
                     /protein_id="WP_088009004.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCLEIFEECKKEKHEKCDNSCVQGIRDE
                     LKKLINQTVQINTEGRTYVGTVLSVSCDVVKLAAIPGSVGVIISICKIEAIFPPVTTVT
                     AEFDFNGVDVANKA"
     gene            18952..19470
                     /locus_tag="I6L50_RS18750"
                     /old_locus_tag="I6L50_18745"
     CDS             18952..19470
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003189378.1"
                     /locus_tag="I6L50_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18745"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_374108394.1"
                     /transl_table=11
                     /translation="MRVIQLVPFKKSDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLE
                     KYTESANTLAFKIIDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMM
                     KAVLCIAFEELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMS
                     MLEYEWNNK"
     gene            19520..20080
                     /locus_tag="I6L50_RS18755"
                     /old_locus_tag="I6L50_18750"
     CDS             19520..20080
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002110020.1"
                     /locus_tag="I6L50_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18750"
                     /product="hypothetical protein"
                     /protein_id="WP_219302311.1"
                     /transl_table=11
                     /translation="MNKKTKIISIAAVSGGGKTTITESLAHELKNSKALYFDRYKFDNC
                     PADICKWIDDGANYDEWVLTPLIHDIQHLIRDGNVDYIIVDYPFAYLNSEMRQFIDVTI
                     FIDTPLDIAMARRILRDFKEGTMDEIHNDLKHYITYARKAYLEAIHTVKPNSDIVLDGS
                     LPVGEIIDQIVEELNLREVIVND"
     gene            20073..20831
                     /locus_tag="I6L50_RS18760"
                     /old_locus_tag="I6L50_18755"
     CDS             20073..20831
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-145). E-value: 7e-13.
                     Score: 40.7. Matches aSDomain:
                     nrpspksdomains_I6L50_RS18760_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172035.1"
                     /locus_tag="I6L50_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18755"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_219302312.1"
                     /sec_met_domain="PF00561 (E-value: 6.6e-08, bitscore: 30.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKCIEEYVQVDDFKIYTKIFQGKKLQPVIIMEAGYGDYSKAWDR
                     IAEGLTEYGTVLTYDRAGLGKSGKSSKRRVSSEMVKELRACLKQLQLKPPYIFVGHSFG
                     GINIRLFTTFYPEDTMGVVLVDSTTENYKEDFLPIMSPEFQEAYYKQFVYESSYEEFMF
                     SLGEADRHCKSMRDIPLVVLAAGKKDFYSAAAQLKWLQLQEELLQLSTSNKFIIAENSG
                     HYIQKDEPHYVIDAVKWIIDMESDKCASFI"
     aSDomain        20154..20507
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6L50_RS18760_Abhydrolase_1.1"
                     /evalue="7.00E-13"
                     /label="I6L50_RS18760_Abhydrolase_1.1"
                     /locus_tag="I6L50_RS18760"
                     /protein_end="145"
                     /protein_start="27"
                     /score="40.7"
                     /tool="antismash"
                     /translation="PVIIMEAGYGDYSKAWDRIAEGLTEYGTVLTYDRAGLGKSGKSSK
                     RRVSSEMVKELRACLKQLQLKPPYIFVGHSFGGINIRLFTTFYPEDTMGVVLVDSTTEN
                     YKEDFLPIMSPEFQ"
     CDS_motif       20355..20390
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6L50_RS18760_0001"
                     /evalue="1.20E-04"
                     /label="NRPS-te1"
                     /locus_tag="I6L50_RS18760"
                     /protein_end="106"
                     /protein_start="94"
                     /score="14.6"
                     /tool="antismash"
                     /translation="PYIFVGHSFGGI"
     gene            20815..21273
                     /locus_tag="I6L50_RS18765"
                     /old_locus_tag="I6L50_18760"
     CDS             20815..21273
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="I6L50_RS18765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18760"
                     /product="DinB family protein"
                     /protein_id="WP_219302313.1"
                     /transl_table=11
                     /translation="MLVLFRYNWQVRQDWFKWCEQLTEEELLRKRVGGVGSILETLFHI
                     VDVEYSWISALQEKEDNEPQFKDYQSIKKVKALSNSYRRELEEFLQIWSGDLEYKILKA
                     SWTDKTYKYGEVLRHVIVNEIHHIGQISIWVRELNLQPVSANLIGRRL"
     gene            complement(21331..22347)
                     /locus_tag="I6L50_RS18770"
                     /old_locus_tag="I6L50_18765"
     CDS             complement(21331..22347)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="I6L50_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18765"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_219302314.1"
                     /transl_table=11
                     /translation="MQFLKKITVLLLSFLITALIVLYFYLYVNGPIIQAKSAILIDTNS
                     GEIVYKKNEETPIQSATLSKLMTEYIALEQLNEGKIQLDELVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALFLTGNNRSALALAEHIAGNEDNFTLLMNDKAKQLKLSQPSPFLNA
                     TGINNDTNKQSTTTSIDVAKLAIQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTATRGDTRLISVILDAGDENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTILFQFKNLIIQTIMIFFIITILMFLYIRQKKAEDFN"
     gene            complement(22529..23686)
                     /locus_tag="I6L50_RS18775"
                     /old_locus_tag="I6L50_18770"
     CDS             complement(22529..23686)
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127015.1"
                     /locus_tag="I6L50_RS18775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18770"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_219302315.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIFRLVTSVIES
                     SLTLSELGKEFIRIFGHEKYIGLKESLWMMIVSYLFLFSIFSSYLYIFYRHERKVYYET
                     CIKKMIEEIRYIASGNFNHKVSIVHHNYLEELATGVNQIIEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAITYGNDGDHIDITAYESSNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLLPYKA"
     gene            complement(23676..24371)
                     /locus_tag="I6L50_RS18780"
                     /old_locus_tag="I6L50_18775"
     CDS             complement(23676..24371)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="I6L50_RS18780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18775"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002016575.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKDIVELLAVYLRNEGYNIYKAYDGDEALQMICTY
                     EVDLMLLDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            24569..25177
                     /gene="yqeK"
                     /locus_tag="I6L50_RS18785"
                     /old_locus_tag="I6L50_18780"
     CDS             24569..25177
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966604.1"
                     /locus_tag="I6L50_RS18785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_18780"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_219302316.1"
                     /transl_table=11
                     /translation="MLYNDIYSFTPTGKIENDIKAFLLKYNKEFTYKHSIRVANEARKI
                     AGIFYEDEEKAAIAGCLHDISAIFPNEERIAVAEKFGIEILQEEREFPMIIHQKLSRVI
                     AKEIFKIEDEEVLNAICCHTTLHKHATKMDLVLFIADKLEWDQIGTPPYLINVKKALGN
                     SLEHAAFVYISYLWERKDTLKVIHPWLEEAYWYLKEIVE"
ORIGIN
        1 actcggatcc caaaaatagg aagaattaag gcctttgtat ttattaagta tttcctcgaa
       61 tgatagtgag ccactttcag gagtagtttc ttcttttaag cgcattaaaa ttgtttctgt
      121 aggatgatct tttaaaaatt gaattgcctc ttttaataca tcttcaaaca ttgctttttg
      181 atttacaatc ccatggtaca ttgcaaaaga atcttttaca catttaacac gcatatctac
      241 atatcgaatt ccggaattta attgttgtgg tagactcata gtttgatttc ttgtcaaatt
      301 ttcatcaaga aaacttgctc catgtaaagc cattgtaccg tgagtccctg gaatagatat
      361 ttcactcaat tttgttgaat ctgctacttt cgacatccat gctgggtttt gatagcctat
      421 attggattca taggaataac ctggatgact atcagcaaaa atagtagatg gtgtacttaa
      481 acttgctagt gtgaaacaag taaggatact aattttaaaa aaattcctca tttttatttt
      541 gttcatttta tctctcctga cttttaaaca atagatataa taaaacaaga tgatttttta
      601 ctacatctat tgttttcatt cttaaagtaa tgaatttttg tgtttgaaaa aatcaaaata
      661 gggtaggaag ttatttgaga ttttaatagt ttattgtaat aaattgcatc taatagtcaa
      721 acggattctt aaagaattga agcatagata ggtaaaaaac aaactttccg ctgtactgta
      781 tacaaacaaa acagaagtct taaaaaagac ttctattttg tgacatataa tgaatgataa
      841 ggtggttaac aaatcaagat aatgtgactg agtggtaaaa atctatttat agctgtttca
      901 gaatttttta taacaaggtt acttatgaaa aatgggactc tgttaggcta acaaaaatta
      961 agaaattcta ctcattaaaa cttaaactaa ctacagttgc gatagattgg gctgcatgtt
     1021 cccagcttcc atctatcact tttccaatct gttgaccaag tgcatttaaa tcatttggat
     1081 taactggaat cccattatac gcagcaagaa ttgataaaag tggagcagca aatggtgtcc
     1141 aaccacctct atcaatatta aatacaggct tatctattac ctttccatct tgcactgtaa
     1201 actcataata aaattgatca tctggacgaa aacttaaatg atgagaaatt tgtcccttaa
     1261 catatgtttt accgccacct aaatttacta cttcaattgg ttttacatta aattcatgct
     1321 caaatacttt aattttttta acttctggac catttaaggc agctttaact gctgtttcca
     1381 aattattttg tgcaaatggt tgaatactca tctgtgtctc ttcttgttgg ataggagcct
     1441 ctttttcagc agcaaacacc gatgtacttg gtagtgcacc tgtagccaat gtagctgcaa
     1501 gtgctgtcgt catcatgatt tttcttttca tcttcatagt tttcttcctc ccttaaagtt
     1561 atgatatata attttttaaa gactgacatg gggcaatatt ttatttcata atgcacgaaa
     1621 aaaatagttt aagaattatg tgaaattatg tcagaaaatt aaagttaatt atatatgcac
     1681 ttacaatgat agctatctac acacgttttt tcaattttct aacaaatgat acagtaatac
     1741 cttttcataa ggcaatttag tgtttcaatt ctctctttgt acgttttaaa taaattaaaa
     1801 tcgtagtggt aataatatat ttgtaatcaa atgtcgtata tacttcgaga aaagtacaca
     1861 atatttttat aaaaaaccat aggaaatatc atgatatagt tatcaaacta agtaagataa
     1921 atgttaatat tatgaagata ttccagtgat ctgctataaa attactgaaa aatgagcatg
     1981 acatcataca cacatgcgat tgaaaaattt tataagtggc gtataaaact ataacaaata
     2041 ctacaaatca attaaaaaat ttcagttatt ctgaatgcga agggcacgta atatttattg
     2101 tgaactgtag tactgattaa gattttagga ggaagtatga acaagaagac taaaagaatc
     2161 atattaatta ttggtatatt agtaggcatt agtatctttt tatatttaca aaacaattta
     2221 ataagtataa ctgaggttaa aataacctct agtaaaattc cctcttcttt taaaggatat
     2281 aaaatactac aaatttcaga tttacataat aaaaaatttg gtgataatca agacgtttta
     2341 attcaaaaag taaaaagcat aaatccagat attattgcta ttacgggtga tttaatagac
     2401 agtaaatcgt acgatgcaga aatgagtatg caagtaatac gagaacttgt gaaggaatat
     2461 ccagtatatt ttgtgacagg aaatcatgaa aaatggtcag gaaaatataa cagtttagaa
     2521 aaaaaattaa agaaacagca tgtcactgtt ttaagaaatg aacatgtaat aatacaaaag
     2581 ggaggacacg aaataaactt gttaggaatt gatgatccgg aatttaatac tggagatatt
     2641 gatgaaggaa gtattgtaaa agatgcaatt gtaaaagcaa aaattgaaac gcagccagat
     2701 aggtataatg tattattatc ccataggcct gaatttctag aagagtatgc tgaggagaaa
     2761 gtagatttag tgttatcggg tcatgcacat gggggacaag ttcggttacc ttttatcggg
     2821 ggattagttg ctcctaatca aggaatactg cccaaatata cagcgggttt atatgaacaa
     2881 caaaatacgt ctatgatagt tagtagagga ttaggcaata gtatcattcc gcaaagagtt
     2941 tttaatagac ctgagattgt agtcgtgcag ttaaattaat ctgtatggct tttttgttca
     3001 ggagaataat ttaaaggtag tttttcttga gtacaagttt ccattacaat tttgttaaaa
     3061 tttttcaagg ttacataaag taacaaaatt tgacctattg agtttgttat agtgtaaata
     3121 atcaaaaaac ttaaaaatta gtcgagttaa aatagttatt attaagcaat attaaaaata
     3181 taaaggggtg tacaaatgca taaagaattt gaaattgaag aatatacggc gattgaggag
     3241 caaattcatt attatagtac gtctttatta gtaagtcatc ctgagcaaat tgtaaagtat
     3301 ttagaaaaac ggttggaaaa gtatgcagaa acgttacaat atgcacattt atatccggaa
     3361 acggttatat taccaataca gcaaatagtt atcgaatatt ctttagatgt tgctagaatt
     3421 agaaggtatt taaatttaaa aacataacaa aaatcgaata atttacaatg aaacagagtc
     3481 gactttaaga aaagatattc taatgtcgac tctgtttcat tgatttagta aataacagaa
     3541 aaaatatgtt tgaaaagttt gacatataat aattcgagag taaaataaaa gtgagtactc
     3601 actcatttta aagaaaaggg ggatttttag tgcagcaacc ttcaattatt ttacgagatg
     3661 tatcaaaaag ttttgggaaa aaagaagttt tgcataacct ttcgctgcaa gtagaaaaag
     3721 cagaaatttt tggcttggtt ggaccttccg gatcagggaa aacaacactc attaaaatga
     3781 ttgcaggtat taatgagtca actacagggg atgtaattgt ttttaataca aacatgccta
     3841 atctaaatga aatgaaaaga attggttata tggctcaggc tgatgcatta tacgaagaac
     3901 tatcggcata tgaaaatgca gattttattg caacgatgta tgggttaaaa ggtaagcgta
     3961 agaaggagag aatcgtagaa gtttttgaac ttgtgcaatt atcagagcat atgaaaaagc
     4021 aagtacagca tttttcaggt ggaatgaaaa aacgtttatc attggcgata gcactccttc
     4081 atgaaccaga aatattaatt ttagatgagc caacagttgg gatagatcct ctacttcgaa
     4141 aatcgatttg ggagaagttt tatgacctta aaaagaaagg aacaactatt attgtaacaa
     4201 cgcacattat ggatgaagct gaattttgcg aacgtctagg gctaattaga gaagggaatt
     4261 tagttgcgat tggcacaccg gaggaattga aaaaacaaac atcttctgga cgaattgaag
     4321 atgtctttat gttagaagga gtgattgaat catgagagtt aatggtgtag tcatccgtat
     4381 cattcgtcaa ttttttcgag ataagcgttc tttagcaatg atgtttgggg caccaatgtt
     4441 attactttgg ttattgtcgc tagtatttac acaaaaagac tatataccgc atattgctgt
     4501 agtcgatgta cctgctccta tagtaaaagt aatgaaaaat caagaagcat caatttatga
     4561 atatagtaaa gacaaagcaa tttcggaatt agagaagcaa aaggtagatg cagtaattca
     4621 tttagaaaat ggaaaaatga atcttctatt agaaggcagt gattcatcaa aaaaccgtgc
     4681 ggtacttcaa gtattgcaaa agagtacaga gaagaatgat gtatcaatga tgaagcctga
     4741 agtggattat ttacatggct ctaaagacat tacgatgttc gatgggcttg gtcccgtatt
     4801 aattggtttc tttacatttt tctttgtatt tatattgtcc ggagtatctt ttgtaagaga
     4861 acgtttaagt ggtacattag agagattatt gtccacacca gtgagaagat gggaaatagt
     4921 tttaggatat attattggtt ttggaatctt tgcatttata caatctatta taattgtaag
     4981 tttttcagtt tatattttag atttatatgt agctggctca atatggctaa cgctacttat
     5041 aacatgtatg ctttctttaa ctgcactaac attaggcaca tttttatcgg catacgcaaa
     5101 taatgaattt caaatgattc aatttatacc gcttgttatc gtgccacaag tcttcttttc
     5161 tgggttgttt ccaatggaat ccatgaatac atggttacaa atgttaggta aattatttcc
     5221 actcacatat ggtgctgacg ctatgagaca agtaatgatt cggaatcaag ggtttacaga
     5281 gattgcatta gatcttactg tattactact tttttcacta ttatttgcag taggaaatgt
     5341 atttgcatta aagaaacatc gcaaaatata atgatgataa aaaggagcac aataaatgaa
     5401 gaaggattgg ctggaagaat tagttgccgc aacgaatact gataaacgta atgaacgtca
     5461 aatgcgtata ttagaggcag ctgttgatat gtttggagaa aaagggtacg cctcaacttc
     5521 aacgagtgaa attgcaaagc gagctggtgt agcggaagga acaatcttcc gctactataa
     5581 aacgaaaaaa gatttattgt ttgcagtcgt gatgccgacc ttaacaaagt ttgctgcacc
     5641 atttttcgta caagcctttg caaaagaaat atttaaaaca gagtatgaat cgtatgaagt
     5701 gcttttaaga gtaataattc aaaatagatt tgaatttgct aaaaagcact ttccaatgat
     5761 aaaaatatta attcaagaag taccatttca gccggaacta aaaagtgaaa tacaacaatt
     5821 aatagaaaca gaactgcttg tacattttaa aaaactgatt gcaaagtttc aagaagaagg
     5881 ggaaattatt gaacttccgc catcttccgt attacgtctt actttatcag ctgtattagg
     5941 gttgctctta acgaggtttt tattattgcc ggaagagaaa tgggacgatg aagtggaaat
     6001 tgaaaatacg attcaattta tattgtatgg actaacgcca cggaggtaat gtgatgcgac
     6061 aatttgctaa accgataatt gttgtaagta aatgtttaga atttgatgcc tgtcgttata
     6121 atggagagat ggttccagat ttaacaattc gaaacttgca gccatttgtt acatttatac
     6181 ctgtatgtcc tgaagtagaa attggtttag ggactcctcg tgaaacgata cgtattgtag
     6241 aaaaaaatgg agcgaatatg cttgtacagc cgtcaataca agaagatgta actgaaaaaa
     6301 tgaatgaatt ttcaaatgca tttttacaaa cattacctga agttgacggt tttattttga
     6361 agaatcgttc gccaagttgc ggaactcgtg atgtgaaaat ctattctggt tttgaaaaag
     6421 ggccaataaa aggaaaagga actggattat ttggcggagc agtaataaaa aaattttcgc
     6481 atcttccaat tgaagaagaa ggtagattgt cgaattttat tattagagag catttcttta
     6541 caagattgtt tacaatcgcg cattacaaaa tgattaaaca tactaaaaac ataaaagaac
     6601 tcgtagcgtt tcaatcagat tataagtatt tatttatggc atataatcag gtgaaacaaa
     6661 aagaattagg gcgtattatt gcaaatcaaa aaaatgaaac aatggaagtc gtatttgata
     6721 actatgagaa gactttatat gaattattta tgcgcgcgcc tcgctataca tcgaatgtaa
     6781 atgtatgtga gcacattttc ggatatttta aaacaaagct aaaaaaacaa gaaaaagatc
     6841 attttctaga actgatacaa aaatatgcag aaaagaaaat accacttagt agtttgctta
     6901 caattttaaa atcatgggcc attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 ttgagccata ccctgaaggg ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattggtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattcgt gtcttttaag aagtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcggaatttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattgtt aggtatccca ttcccggaag agtatggagg ttcaggtggc gatacgttat
     7441 cgtacgcgtt agctgttgaa gagattggtc gtgcttgtgg tggaacaggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 agaaattttt agttccaatg gcgtcaggta aaacgttagg tgctttcgga ttaacggagc
     7621 caaatgctgg atctgatgca gggggcacac aaacgaaagc aattttagat ggtgatgaat
     7681 atgttattag tggtgaaaag tgctggatta caaacgcaga gtatgcaaac acaattattg
     7741 taaccgctat caacggtttt gaagacaatg gtaaaaaacg tatttctgca tttatcgtac
     7801 cgactactag tgaaggatta acgatttcaa gcccttacga taagatgggt gttcgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tacgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaattg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcattacaa tatgcgaaag
     8041 aacgtcaaca atttggaaaa ccgatttcta atttccaagc gattcaattt aaattggctg
     8101 atatggcgac tgaagtagaa ttagcgcgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa gttgtttgca tctgaagctg
     8221 caagtcgtat agcaaatcat gcagtacaaa ttcatggtgg atatggctat atgcgcgaat
     8281 atgaagttga acgatatatt cgtgatgcaa aactgttaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gcaagacatt taggatgtag ataaaaagga ggagtcacta
     8401 tgtttcaaaa aatattaatt gctaatcgcg gggaaatcgc agttcgtatt atgaaaactt
     8461 gtcaaaaact tggcattcgt accgttgcta tttattctga ggctgatgaa aatgcccttc
     8521 atgtaaaatt ggcaaatgaa gcttacttag taggcggtcc acgtgtccaa gaaagctatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgctgaagca atccatccgg
     8641 ggtacggatt attatcagag aatccatctt ttccgattcg ctgtaaagaa gaaggaatcg
     8701 tatttatcgg tccttcagaa gaaatcatta ctaagatggg aagtaaaatt gagtcacgta
     8761 tagcgatgca agcagcagat gtgccagtag ttccaggcat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcgaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 cgggcggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa taaaacaaga gcgcaaaatt tctttggtaa cggagaaatg tatttagagc
     9001 gctatatagc agatgcacat catattgaaa ttcagctttt agcagataca catggtaata
     9061 cagtgtattt atgggaacgc gaatgttcag tgcagcgccg aaatcaaaaa gtaattgaag
     9121 aagcaccttc accattttta gatgagggta cacgaaaggc tatgggagaa gttgctgtac
     9181 aagctgctaa agcacttggt tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 aaaagaactt ttatttctta gaaatgaata cgagattaca agtagaacat ccagttacag
     9301 aagaaattac tgggttagac ttagttgaac aacaattact tatcgcatat ggtgagaagc
     9361 tatcatttac acaggatgat gtaaaacgta gtggtcatgc cattgaggct cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccatcac ctgggaaaat tacagattta acgttaccaa
     9481 caaatatacg tattgatcat tttttggaga atcaagtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtaatc gctcatggtg aaactcgtga agaagcgatt tcaaaattga
     9601 aaattgcact agaagagtta aaagtagaag gtattaaaac aaacacacca atgttactgc
     9661 aagtactcgg agacgatgtg ttcaaaagtg gtatttatac aacaggtttt gtaacgaaac
     9721 aacttgttaa aaaataagag ttatgaatat taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tttggaaaat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatcg tttcagaaga
     9901 agccggaact gttatgaaaa ttaacgtaca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cgcgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagcg ggattgtcgt acgttgaagt
    10141 ttcctcattc gttcacccta aatgggttcc tgcattagca gatgcaagtg atgtattttc
    10201 tgagctaaaa agggatccaa atgttacata tgcagcgctt gttccgaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcacaataaa agtaatatta ataaatctat taaagaagca ttagctgtaa ttgaagatat
    10381 aacaaaacag gcaacgttcg aaggtaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgccac agcagttgac gaaatatgta atcaactatt
    10501 ttcatacggt atttatgaaa tctctcttgg tgacacgatt ggtgtagcga atccgttaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctggc gaatgtagtt aagtctttag aatatggtat
    10681 tacaacgttt gatagttctt gtggtggact cggaggatgt ccttatgcac caggagcatc
    10741 gggtaatgtt gctactgatg acttagtgca tatgctccat aagctgggag tccaaactaa
    10801 tattgatgaa gaaaagttat tgagagctag tcagtttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgctcca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgactatg ttacaccgca cgttgtaaag atttcgttaa
    10981 atcgtgaaag acaagcaaac tcattatctt tggcattatt agaagaatta caaactatat
    11041 taactcaaat aaacgaagaa tcaaatacgc gcgttgttat tttaacaggg gatggcgaaa
    11101 aagcattttg cgctggtgct gatctaaaag agcgtgccaa catgagtgaa gaacaagttc
    11161 gccatgctgt gggtatgatt cgttctacta tggagatggt tgaacaatta ccacaaccag
    11221 ttattgctgc tattaacgga atcgcacttg gtggaggtac tgaattaagc ttagcttgtg
    11281 attttagaat tgcttctgac actgcaagtc taggtctcac ggaaacttcc cttgcaatta
    11341 tacctggggc gggtggtact cagcgcttac ctagattaat tggagttggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cgcaagaagc gaaagagtat ggtttagtgg
    11461 aattcgtagt accagctgat ttactagaag agaaagcaat taaaattgca gatcgaattg
    11521 ctaataatgg tccaattgcc gttcgattag caaaagaagc aatttcaaat ggtattcaag
    11581 tagatttaca taccggctta caaatggaaa aacaggcgta tgagggcgta atcgatacga
    11641 aagatagatt agaaggatta caggcattca aggaaaaacg caaaccaatg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc taattcattt gaagaacggg ttgaaacaat
    11761 taagcaaggc ggggcaccga aatatcatga acaaaacaaa gcaaaaggaa aactttttgt
    11821 tcgagatcgt ttagctcttt tattcgataa tggtgaatat gtggaagatg cattatttgc
    11881 aaattgtgaa caaactggat taccagctga cggcgttgta actgcgactg gtaaaataca
    11941 tggtcgtact gcgtgcgtaa tggcaaatga ttcaactgta aaagctggat catggggagc
    12001 acgtacagtt gaaaagattt tacgtattca agaaacggct gagaaattac gtgtaccgtt
    12061 attttattta gttgactctg ctggggcacg tattacagat caagttgaaa tgttccctgg
    12121 acgccgcggt gcaggaagga tcttttataa ccaagtgaaa ttatctggta aagtgccaca
    12181 aatttgttta ttatttggac cttcagcggc tggtggtgcg tatattccag cattttgtga
    12241 cgttgttatg atggttgaag gaaatgcttc tatgtattta gggtctccgc gtatggctga
    12301 aatggttatc ggtgagaagg taactttaga agaaatgggc ggagcacgta tgcattgctc
    12361 agtatcagga tgcggagatg ttttatgtaa aacagaagaa gatgcaatta cgcaagcaag
    12421 acaatatatt tcttattttc caagtaacta tttagaaaag actcctttga ttacacctca
    12481 agaaccgaaa cagttcgata aaacgttaga agaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaacagaat tattgatgaa agttctttct ttgaagtgaa
    12601 aaaattattt gctcaagaac taattacagg tttagcgcgt attgatggta agccaattgg
    12661 cattattgca aatcagccgc gtatgaaggg cggcgtttta ttccacgatt cagctgataa
    12721 agcagcgaag tttataaatt tatgcgatgc ataccatatc ccattattat tccttgcaga
    12781 tgtacctgga tttatgattg gtacaaaagt agaacgtgcc ggaattattc gtcacggtgc
    12841 aaaaatgatc tctgcaatga gtgaagcaac tgtaccgaaa atttctatcg tcgttcgaaa
    12901 agcatatgga gctggcttat atgcaatggc aggtccagcg tttgaaccag attgctgctt
    12961 agcattaccg acagcttcta ttgcagtaat gggtccagaa gcagcagtca atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgtgca agctttattg ctgaaaaacg
    13081 agaagagtat aagaaagata ttgatattta ccgtttagca tcagagatgg tgatcgatgg
    13141 tattgttcat ccaaataatt tacgtgaaga gttaaaagga cgattcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gtcaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga atataaagaa aaaacgcgtt tatttggttg gatgaaatca ttaggctatg
    13381 aagattacga agctttttat aataagtcaa ttgaagaaac agcatggttt tggggagaag
    13441 ctgagagagc agttggctat cagtggatga aaccatatac agaagtgtta gatttagaaa
    13501 atggtacacc gtttgcacag tggtatactg agggaacttg taacgttgta gaatctgctt
    13561 tatctcgctg gcttgcagac gataaaatga aaacacaagc agcacttatg tatgaagggg
    13621 aaaacggaac ttcaaaatca tttacatatg aagagcttga tagctgggta agccgtgttg
    13681 ccaacggttt gaaacatgct ggtattgaaa aaggtgatcg tgtaacaatt tacatgccaa
    13741 tgattcctga aacagttgtt gctatgttag cggtaatgaa aattggagcg attatttcac
    13801 caatattctc aggttttgct gctgatgcag taatgacacg tgtacaagca gctggttcaa
    13861 aaatgattat taccgcagat ggcttttcac gccgtgggaa aattgtttca ttaaaagatg
    13921 aagtggataa agcttgtgaa cattgtccaa ctgttgaaaa ggtggtaatt gttcgtcatg
    13981 caggaaatga ttttacaccg cataattatg atttttcatg gagtacgtta gaaaaagaaa
    14041 aaccatttag acatgctgaa gaaatgaaca gtgatgatcc attaatgctt atatatacat
    14101 ctggaacgac tggtaagccg aaggggacag tacacacaca tgctggtttc ccgctaaaat
    14161 ctgcatttga tgcaggattt ggaatgaata taaaacaagg cgaccgcgta ttatgggtaa
    14221 ctgatatggg ctggatgatg ggaccatttt tactattcgg ctctttaatt aatggcgcaa
    14281 caatggttat gtacgaaggt gttccagact tcccagaagc agatcgctta tgggagacag
    14341 ttgataaata tgaaattact catctcggta tttcgccaac gttaatccgt gcattaatgg
    14401 caaaaggtga tgaatatgta aataaacact cgttaaagag tttagaagta ttcgcatcaa
    14461 caggagaacc ttggaatcca gacccatgga tgtggttatt taatacagtt ggtaaaggta
    14521 aagtaccaat ttgtaactat tcaggtggaa ctgaaatttc aggtgggatt ttcgggaatg
    14581 tcctaattaa gccgatcgca ccgattagtt ttaacgcatc tttaccagga atggcagcgg
    14641 ttgtacttga tgatcgaggt aaaccaattc gagatgaagt cggagaatta tgtttagaaa
    14701 aaccttgggt aggtatgacg aaaagtttct gggaagatga tgaacgttat gtaaacacat
    14761 attggtcacg ctttgaaaat aaatgggttc atggtgactg ggtcatttat gacggtgaac
    14821 aatatatcat tacaggccgt tcagatgata cgttaaacat tgctggaaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataataatgt aatagaagca gctgcaattg
    14941 gtgtacctga cgatgttaaa ggtgaggttt gtcattgctt tgtagtatta cgagacggtg
    15001 taatatttac agcagaatta aagaaagaat taatgagttt agtaaattct catatcggaa
    15061 aagcattatg tccaaaagat attcatgttg tagaagattt accaaaaaca cgtaattcta
    15121 aagtaatgcg acgtgttatt aaagcagctt acttaggaaa agagttaggc gatttatcgt
    15181 cactagtaaa tcccgaagta gtacccttca ttcaaggact acagtctagc aaactataac
    15241 attacgaatg agctctatgt aaatagagct catttttaat gttcacaaaa agataagaga
    15301 aaaaaagtaa atttgaagtt aaaaaatcta ctattagtgg taagtatgtc tgtttgtttt
    15361 tagtttttat caaaatagga tactgagact gtctattcaa tggagtgatt gaattttgtt
    15421 aagaatgaaa atttagtgaa gaaaaagtaa tgaataaaag gagaaatccc tgggggacag
    15481 ggattcgata agggagataa tattgtcgtt caatgtcgaa atttggcgta tccgacaaat
    15541 taatattatc acgaattttc aggagattgt gatagtggat gtgtcaaaaa tgtgtacgtg
    15601 tttcatataa aaatattatt taaataggaa aagggaaaag aattaagttc actcgttctt
    15661 aagatttttc ccttttaaat ttactgtttg ttcgttgttc tatatacatc agaaattggt
    15721 aaatcttcgc catgtaaagc ttgagtactg tcctttttat ttgaatcatg tgcctcctga
    15781 gatgcctctt gcatttgctc ttgggcttta ctaggagtat tcagcgcatc cgatgacaca
    15841 taatcaagtt gttgacttaa tagatttttc ttatccatgt tatgtagctc ctttttgaac
    15901 ttagatataa aaacgatgtt ttttaaatag ttacgtgggt attatgtatc tttgaatgga
    15961 attatataca caaactatat tgagaattta actaataata aaaagtactt gtgatgacaa
    16021 gcttaagaaa tataaagatc attagtcctt aatgaaagcg ttattttagt atggtgtaga
    16081 ttaaatagga cctgttgtat ggaacaagtc ctttcaaaaa tgacaacaga taatgaatgg
    16141 gggttacttg aacatttcta ttagtggtaa ctagatccca ttcgttggat gctacgaaat
    16201 ttcatttgaa aggaacatcc caatgataag atgagcactg taaatctgtg ctcatcttat
    16261 cagaaattgc ttagtcctta aaaataaaac cgttacggac aattcacaat ggtaatagtg
    16321 acgtttgcca atcaagaagt gaagcagtaa cggttactgt tccaggccca ttagcggcta
    16381 gaaatacagc ggtaaagtta cctgaagcat tggtaatgac agcaagagga accatgaaag
    16441 caagagaagg gttactaaat gaaaaactga ctactactcc tggagtagga ctaccgttta
    16501 ctaatacttg acccgaaaaa aataaagtat tatttccttg agtggataca catgctgtgg
    16561 tttcgttaga agtcaaggta atagatgcag gcccagcagg aagattaaat ccagttggtc
    16621 cagttggtcc agttggtccg gttggtccgg ttggtccggt tggtccggtt ggtccagttg
    16681 gtccagttgg tccagttgaa ccagttgaac cggtagcacc agtagctcct gtagaaccgg
    16741 tgggaccagt agggaattga aagggttgaa caggtggaag tgtaggtcca atagaactcg
    16801 gattaagtgc agcaaaagat aaaaactcgt ccattatata tcacctctaa aaatcgtatt
    16861 actaatagta aatgtaatga tagagcaaag tgaaatggac aagcggttgt attttaataa
    16921 attaaacaaa atagttattt gatagaaaga gagattagta tgattacttt agaaattaaa
    16981 tataaaaagg cgattatctt caaatcgcct tttgggtaat gcagtgtaat tttattcagt
    17041 tatttgaaat atagtttcat tcggtttaga aaatccatac agtttccttg cgaattttaa
    17101 aatttcttct tcactacctg ttaaaacttt aacatcattc ttaagggaat gaccatcctt
    17161 ctttacagaa gataattttt gttgctccgt attcagtgtg atttgttttt ctttaatcat
    17221 ttcttgttgg ttattcagag aatattgaag ggcaaaaatt ataggtaata taatagccaa
    17281 agtaattata atacggcgtc ttgttttttt aatatgacct tgttgggtat tagggttcac
    17341 ttgctgtgag ggtatcttag gatttgattg ttgtgatgat atttttggga tgtttcccat
    17401 taaaatgcct ccattactga ttgtagaatt taaatcgttt aaaagtatta taaatgttca
    17461 atgggaattt tagaagatat tttaatatag gtgagttttg taaagtttaa acaaaatcct
    17521 tatttaaata aaaggaaccc cgattgtctg cggggctcct aagggtaatc gtcaagtaat
    17581 gacgtactcg actagttaac gatatcatga attttttggt aaatatactg gtaaatgcgt
    17641 ccaaattaat aagagcatca tttgaaacaa aaacgctatt ttaatagggt cgggaataat
    17701 gatgattcca tgggacaaac gagtaaacgt tttatcaagg tgattatttt attaaagagg
    17761 ggacagtttt agaggttagt gaaagggtga ataaatcatt aggttggctt cggtgcatgt
    17821 tagctccaaa ctatgaaaaa gtgtacggtg atagtacata gcgactgcgg tcgattcggg
    17881 tagatgataa tgaagaatga tataaaaatt tcatttcgta gagaaatatg ttgattaagg
    17941 atgggcattg aatatgccat gtttgtatga ataaagagca gaatttggcc tatataaagg
    18001 tgctggaatt gttctaaagg ggatctacat aattgcatat cctgaatcct ccaagaaaac
    18061 agactttgaa ttaagggttc tatctacacg tatagcgctc gctatcattt gcgccttggc
    18121 tttatggatg cttatagtaa tctatataaa ataattcttt tctaataaga aatatactaa
    18181 aatatgagaa aatgctgtaa taataattat acatttagtc ctactggaag aaccagtgca
    18241 catcaaacta aaaagggcgt tgttatattg ctctgtagtt tggtgtccgc ttttttattt
    18301 tttattaaca aaatagatca gtggtgtttt tataaatgac gcaatttcgt ttttagtata
    18361 taaaaagaag gtttagtaca agtgtttgtt tttttgtttt tatgctttcg tctcgtacac
    18421 ttttaagcta ttggacatac tttactaata gaaaggatta gggggtgagg ttttgggttc
    18481 tcgatttaat aattgtaaaa agaagtgtac atgtaaacag gatgattgtt tggaaatatt
    18541 cgaagagtgt aaaaaagaaa agcatgagaa atgtgataat tcttgtgtac aaggaattag
    18601 agatgagctt aagaaattaa ttaatcaaac agttcaaatt aatacagagg gacgtactta
    18661 tgtaggtact gttttgtctg taagttgtga tgttgttaag cttgcagcta ttcctggatc
    18721 tgttggagta attatctcca tttgcaaaat tgaagcaatt ttccctcctg ttacaacggt
    18781 taccgctgag tttgatttta atggtgttga cgtagcaaat aaagcataat tatgctgttt
    18841 tttgtaaagc cattcttatg aatggcttta ttttaatttc gtataaaagg agaatatatt
    18901 ctttatatag aaataggttt gaggctataa agagtgatgt acgaaaggag aatgagagtg
    18961 attcaattag tgccctttaa aaaatctgat ttcaaacaat taataaattg gattaattcc
    19021 gaagaatttt taatacaatg gtcgggaaat gcattcacat atcctttaaa tgaacagcaa
    19081 ttagagaaat atacagaaag tgcaaacaca ctggcattca aaataataga tgaagagact
    19141 aaagcagtta ttggtcatat ttctcttgga caaatagata atataaataa gtctgctaga
    19201 attggaaaag tgctagttgg taatacgaaa atgagagggc gttctatagg gaaacatatg
    19261 atgaaagccg tactttgtat tgcttttgaa gaattaaaac tacatagagt aactcttggt
    19321 gtttatgact ttaataagtc agctatttct tgttatgaaa aaataggttt tgtaaaagaa
    19381 ggtttattaa gagagtcaaa aagagtagga gaaacgtatt ggaatttatg ggaaatgagt
    19441 atgttagaat atgaatggaa caataaataa tagtatttta taattatatt atgttaacaa
    19501 aaggggttta gccggaatcg tgaataaaaa aacaaaaata atttcaattg cagctgtttc
    19561 agggggcggt aaaactacca ttacagaaag tttagctcat gagttgaaaa actcaaaggc
    19621 tctatatttt gatagatata aatttgataa ctgtcccgca gatatttgta aatggattga
    19681 tgatggagct aattatgatg aatgggtact tacaccatta attcatgata ttcagcatct
    19741 tatacgagat ggtaatgtag attatattat tgtagattat ccttttgcat acttaaatag
    19801 tgaaatgcga caattcattg atgtaactat atttatcgat acgcctttag atatcgcaat
    19861 ggctagaaga attttgcgag attttaaaga aggtacaatg gacgaaatac ataatgattt
    19921 aaagcattat ataacatatg ctagaaaagc ttatttggag gcgattcata ctgtaaagcc
    19981 aaattcagat attgttctgg atggatcttt acctgtcggt gaaataattg atcaaattgt
    20041 agaggaactt aatctgagag aagtgatcgt caatgattaa atgtatagaa gaatatgtgc
    20101 aagttgatga ctttaaaata tatacgaaaa tattccaagg aaaaaagctg cagcctgtta
    20161 ttataatgga agcaggttat ggtgattatt caaaggcatg ggatcgtatt gcggaagggc
    20221 tgacggaata tgggacggta cttacatatg atagagctgg attaggaaaa agcgggaaga
    20281 gttccaagcg gcgtgttagt tctgaaatgg taaaagaatt aagagcttgc ttaaaacaat
    20341 tacaacttaa gccaccctat atttttgtag gacattcctt tgggggtata aatatacgtt
    20401 tatttacaac tttttatcct gaagatacga tgggagtagt tttagttgat tcgacaacag
    20461 aaaattataa agaagatttt ttgccaataa tgtctccaga atttcaagaa gcttactaca
    20521 aacaatttgt atatgaaagt tcatatgaag agtttatgtt tagtctaggt gaagcagatc
    20581 gacattgtaa gtcaatgaga gatattccac ttgtcgtgtt agctgctgga aaaaaagatt
    20641 tttattcagc agctgcacaa ctgaaatggt tacaattgca agaagaatta ttacaattat
    20701 caaccagtaa taaatttatt attgcagaaa atagcggtca ctatattcaa aaagatgagc
    20761 cacattatgt aatcgatgct gtgaagtgga taatagatat ggagagtgat aaatgtgcta
    20821 gttttattta ggtataattg gcaagtaaga caggattggt ttaaatggtg tgaacaactt
    20881 acagaggaag aattgcttcg caaacgtgtt ggaggtgttg ggagtatttt agaaacactt
    20941 ttccatattg tagatgttga gtatagctgg attagtgcgc ttcaagaaaa agaggataac
    21001 gaaccacagt ttaaagatta tcaatcaatc aaaaaagtga aagcgctatc taattcatat
    21061 cgacgagaat tagaagagtt tttgcaaata tggtctggtg acctagaata taagatatta
    21121 aaagcttcat ggacagataa aacatataaa tacggtgaag ttttaaggca tgtaattgta
    21181 aatgaaattc atcatattgg tcagatatct atatgggtga gagaactaaa tcttcagcct
    21241 gtttcagcaa atttaattgg aaggcgatta taaatttaga ggccgacttg catttgtatt
    21301 gcaagtcggt ttttatatta aagagaattt ttaattaaaa tcctcggctt ttttttgacg
    21361 tatatataaa aacattaaga ttgtaatgat gaaaaagatc ataatcgttt gtatgattaa
    21421 atttttaaac tgaaacaata ttgtccaaga tgtaacagca tctttaaaag cttggagtgc
    21481 agagtacgag gaaggatcaa aaccgtactg aagtaacttt tttgtttcaa taaaagtact
    21541 gttttcatca ccggcgtcta atattactga aataagtcta gtatctcctc gtgtggctgt
    21601 actgacaaaa ctataattac cattagttga aaaactagtt tgtaagccgt caacaccttg
    21661 gagtttaatg tttttattaa gggaatatat cattttattt gtattgaaaa cttttgaatc
    21721 tttgaaggta aattggtaag aggttagttt cgtaacattc aatacatctg gaaagtcttt
    21781 tactaattgt attgctagtt tagcgacgtc tatcgatgtt gtagttgatt gtttattcgt
    21841 atcgttatta attccagtag catttagaaa cggggatggt tgtgataact ttagttgttt
    21901 tgctttgtca ttcattaaaa gtgtaaagtt atcttcgttt ccagcaatgt gttctgcaag
    21961 ggcaagtgcg gaacgattat tccctgtcaa aaacaatgca tgaagtaaat cacgaaccgt
    22021 cgttttatct ttggaagtta cttgtatagg actcgtttct gctcggaaaa cttcgttact
    22081 tatttttact aattcatcta actgtatttt tccttcattc agttgttcca gtgcgatata
    22141 ctctgtcatt aatttagata aagtagctga ttgtatagga gtttcttcat tttttttata
    22201 aacaatctca ccagaattag tatctattaa aatagctgat ttagcttgaa taattggacc
    22261 atttacataa agataaaaat ataaaacgat aagtgcagta ataagaaaag ataataataa
    22321 aactgttatt ttttttaaga attgcattag cgatcctcct actattacat caataatatt
    22381 attgtaaaaa ggaatgctta attaggaaga aagaaaaggt aaagaatttc taaagaattt
    22441 taaggaattc tttaattttg gatattgatg gaatataaaa ggttcaattt cttatatgat
    22501 aaaaaattga acctataaat atgtggtatt aagctttata agggagtaat tttacagtga
    22561 aagttgtttt tttatcatcg ctatatactt caattgttcc tttatgcaat tcaacaatac
    22621 tttttgcaat tgctaatccg agcccagatc caccagtgtt tgttgaacgt gatttttcaa
    22681 cacgataaaa acgttcaaaa atatgaggta aatcagtact agggataggt tgtccgtaat
    22741 ttgttatatc aattgtaatc atgttactgc tttcgtaagc agtaatatca atatgatctc
    22801 catcatttcc ataagtaata gcgtttatga ttagattttc aaacacacgt actaatttat
    22861 ccccatcagc tagtaccatt agcttttgag atgggaaaga agggcgacat tcaatattag
    22921 cttcttgaag ctgtatccga aattggacag ttaattgtcc aagcaattct acaatatcaa
    22981 taggaacaga atataaactt aactctttat tttgaacgcg tgtatattca aacaagtcat
    23041 tcattaatgc attaagacga gttactttat cgtaaatgac ttgaatatag tatcgtaatt
    23101 ctacttcatc tctataatta tcatgatgga ttaaatttac gtatccaact atagatgtaa
    23161 gaggggttcg taagtcatgt gatacatttg taataagttc gctttttgct tgttctgcct
    23221 gtctttcttc atcaattgat acttttaatt gctcaataat ttgattgacc ccagttgcca
    23281 gttcttctaa ataattatgg tgtacgatgg aaactttatg attaaagttt ccacttgcaa
    23341 tataccgaat ttcttcaatc atttttttta tacaagtttc atagtaaacc tttctttcat
    23401 gacgataaaa aatgtataaa taggatgaga aaatagaaaa taaaaacaaa taagatacaa
    23461 tcatcatcca taaagactct tttaatccaa tatatttttc atggccaaaa attctaatga
    23521 attcttttcc tagttcgctt agagtaagtg aactctcaat tacactcgtt acgaggcgaa
    23581 atataattaa ttcggtaatt ggtgtaagag tgatagctaa taaaagccaa aaaataagct
    23641 tccactttgg tatatctttt aatatatcaa atgcttcatt tctcaatttt atatcctact
    23701 ccccaaaccg tatgaattag tttttcacca ttcattacgg tttcaagttt atcgcgtaaa
    23761 ttactaatat ggaccattac cgttttatta gaaccataac cgtcttcatt ccaaacgcgt
    23821 tcgaatatct cttcagagct aaatactctt ccagtattac tcgctagtaa atataaaata
    23881 tcaaattcga tagaggtgag tttaatatat tctccattta ctttaacagt atgattatgt
    23941 ttatgtattt caacagaacg aatacgaata ataccatctt cattcttttg ggaagtagca
    24001 ttttggaaag aggatcttcg taataaagct ttcactctag ccactaattc tagtggatta
    24061 aacggtttaa tcatataatc atctgcaccg gtcataagtc ctaaaatttt atccatatct
    24121 tcagcctttg cactaagcat aaggataggt acagtattat tttcacgcac ttcttgacaa
    24181 acttccaatc cgtttcgttt tggcatcata atatctaaaa gcataaggtc aacttcatat
    24241 gtacatatca tttgtaatgc ttcatcacca tcataagctt tataaatgtt atagccttca
    24301 tttcgtaaat aaacagccag taattctaca atatctttat catcatcaat aattaatatg
    24361 tttttattca ttttatagtt agttcctttc cttacaatta atcaacatta ctataatatc
    24421 aaacatttat gtattttgta gtaatgtttc tacataaaat ttcatgtatc gtattaaaaa
    24481 ggaattaaaa cattcataac gaatataaaa taagaaggat atttaaactc cacattatac
    24541 tgaaagatag ttataagggg ggcttgctat gttatataat gatatatatt catttactcc
    24601 aactggaaaa atagaaaatg atattaaagc ttttctatta aaatacaata aagaatttac
    24661 atataaacat tcaattcgtg tggcaaatga ggcaagaaaa attgcgggaa tattttatga
    24721 agatgaagaa aaagcagcga ttgcaggatg tttacatgat attagtgcaa tctttccgaa
    24781 cgaggagcgg attgcagttg ctgaaaaatt tggaatagaa atattacaag aagaaagaga
    24841 atttccaatg attattcatc aaaaattatc gagagtaatt gcaaaagaga tatttaaaat
    24901 agaggatgaa gaagttttaa atgctatctg ttgccacact actttgcata aacatgcaac
    24961 gaagatggat ttagtattat ttattgctga taaattagaa tgggatcaaa tagggacacc
    25021 tccatatttg ataaatgtaa aaaaagcttt aggaaactct ttagaacatg ctgcttttgt
    25081 atatatttca tatttgtggg aacgaaaaga tacattaaaa gtcatacacc cgtggttaga
    25141 agaagcatat tggtatttaa aagaaattgt agagtagaaa gggtataaaa atgcaattaa
    25201 aagaatatat gaatcaagca ttcccaggag ttacattag
//
