LOCUS       NZ_JAHWJB010000002     23535 bp    DNA     linear   CON 12-SEP-2024
DEFINITION  Bacillus sp. FDAARGOS_1420 tig00000007_arrow_pilon, whole genome
            shotgun sequence.
ACCESSION   NZ_JAHWJB010000002
VERSION     NZ_JAHWJB010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. FDAARGOS_1420
  ORGANISM  Bacillus sp. FDAARGOS_1420
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2021) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, White
            Oak, MD 20903, USA
REFERENCE   4  (bases 1 to 3674589)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T. and
            Yan,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2021) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, White
            Oak, MD 20903, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 2.1.1
            Genome Coverage                   :: 1241.19x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019344915.1-RS_2024_09_12
            Annotation Date                   :: 09/12/2024 05:20:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,050
            CDSs (total)                      :: 6,900
            Genes (coding)                    :: 6,426
            CDSs (with protein)               :: 6,426
            Genes (RNA)                       :: 150
            rRNAs                             :: 12, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 12, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 109
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 474
            CDSs (without protein)            :: 474
            Pseudo Genes (ambiguous residues) :: 0 of 474
            Pseudo Genes (frameshifted)       :: 199 of 474
            Pseudo Genes (incomplete)         :: 296 of 474
            Pseudo Genes (internal stop)      :: 116 of 474
            Pseudo Genes (multiple problems)  :: 119 of 474
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:39:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 445461
            Orig. end                         :: 468996
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHWJB010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13535](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13535)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            23..799
                     /gene="trpA"
                     /locus_tag="I6L50_RS12555"
                     /old_locus_tag="I6L50_12555"
     CDS             23..799
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016133917.1"
                     /locus_tag="I6L50_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12555"
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="WP_219301735.1"
                     /transl_table=11
                     /translation="MGVEKIIAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASI
                     VEIGIPFSDPVADGPTIQRAGKRALDSGVTLKGIFQALIEVRQEVQIPFVLMTYLNPVL
                     AFGKERFIESCLEAGVDGIIVPDLPYEEQDIITPLLRVANIALIPLVTVTSPIERIEKI
                     TGESQGFVYAVTVAGVTGVRQNFKDEIRSYLEKVKAHVHLPVVAGFGISTREQIEEMIT
                     ICDGVVVGSKVIELLENEKREEICELIHAVKETEEA"
     misc_feature    complement(826..844)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.43"
                     /tool="antismash"
     gene            874..1224
                     /locus_tag="I6L50_RS12560"
                     /old_locus_tag="I6L50_12560"
     CDS             874..1224
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086916.1"
                     /locus_tag="I6L50_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12560"
                     /product="DUF4029 domain-containing protein"
                     /protein_id="WP_219301736.1"
                     /transl_table=11
                     /translation="MLRRKLLYLLLTVPLYAWLISMTKIELMALFLGYVFIFSQLNRIQ
                     EQSILEVCIFSVSIELFSIVAIVLLSELFQWIHSFELIKLGNIVLQVICAYIVFVVLEK
                     MIGQQTVFQDKR"
     gene            1353..2852
                     /locus_tag="I6L50_RS12565"
                     /old_locus_tag="I6L50_12565"
     CDS             1353..2852
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015129 - lactate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015727 - lactate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126004.1"
                     /locus_tag="I6L50_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12565"
                     /product="L-lactate permease"
                     /protein_id="WP_219301737.1"
                     /transl_table=11
                     /translation="MAILLALIPIMMIFICLFLFKQTSLRASLISYAVSVGIVLLSPTF
                     QLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEQVTRDRLLQM
                     LLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTI
                     IGSQLINMPLTTLGTNTALLSIPIFAYFIFLSLYVVGGWQAVIEKWKEGIGFFLLFSLG
                     IYLSNAYVSVELAGILSSIVTISFGFLIIKLKGKDEQNLLTEHAAATEREVSIIKIISP
                     YIFLTVCILLSRLVPALHDFLRSYAVLDLKSYSYKLELLYSPGFWLAMTCLFTIIFFRI
                     PSNVIKQSLSQTTKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFVAP
                     FIGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITL
                     GAYLCNIPYRENELLKKTTLMIFGAVLLVVVEVFFWYILRN"
     gene            2943..3626
                     /locus_tag="I6L50_RS12570"
                     /old_locus_tag="I6L50_12570"
     CDS             2943..3626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128607.1"
                     /locus_tag="I6L50_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12570"
                     /product="DUF2278 family protein"
                     /protein_id="WP_219301738.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKIGKGKTPHYQVHLQGEAGVDYRIAINVK
                     SQSYPSEVLYFASDDIRSEAIHILPTLPFGFTEIKNNEPKVALDYVRGNLFDSKQMIPL
                     PAEKAGVDNDLNEKIERYIKRAIEEKAIIYAFGERWGPEEKVPDSYFHFTPGNGIHDIH
                     MNQGNVEKWQGDDGKWQDGGILIHFEKKEEWIGIFLAFQSQSWCTDEEGHARVPVEHCD
                     YKRNN"
     gene            complement(3641..4474)
                     /locus_tag="I6L50_RS12575"
                     /old_locus_tag="I6L50_12575"
     CDS             complement(3641..4474)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000397498.1"
                     /locus_tag="I6L50_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12575"
                     /product="hypothetical protein"
                     /protein_id="WP_219301739.1"
                     /transl_table=11
                     /translation="MEFVNSIFQTLLTSVIQLFSLIGVIIVIGFILGYLESLTRTYWSR
                     AFGRKGFLLTAWIGVPVHELGHAIMCLLFRHKIVATQFFPTDTSQGALGYVQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPESYYLFNTNLEKTVASTSINLDMIQNML
                     LSTFVLLKSLFTFNNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVIVMFIMLFLF
                     NIIAGLFQYDSNQLIGKMMKYNMYLIAFSSVALLFSCISTLVSFVFYKIRGGRSL"
     gene            4675..5457
                     /locus_tag="I6L50_RS12580"
                     /old_locus_tag="I6L50_12580"
     CDS             4675..5457
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002158836.1"
                     /locus_tag="I6L50_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12580"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_219301740.1"
                     /transl_table=11
                     /translation="MKCPACHTENAAEARFCGNCGHSLTEEVVASGGQEEGQLSRPARV
                     KETRPNETVEQAKQFASGYFQFFKNAFKSPSAIMESGNIEVRNGIVSLVLICFLGACIF
                     YRMMSAAATVTRTLVPDIATPTFFGESVMVFFFLLILTLFVGFIIFVSGKMMKSSFSFL
                     EAFGIWGTIATPAIAILVLSFLFSFLLIFFLPILLGLATTYMGISIIVAILKLDNGRLD
                     PVYTLMIASVLIGIATFLVFWSYINTIIQTFTGGLTGF"
     gene            5477..6712
                     /locus_tag="I6L50_RS12585"
                     /old_locus_tag="I6L50_12585"
     CDS             5477..6712
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016128956.1"
                     /locus_tag="I6L50_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12585"
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_219301741.1"
                     /transl_table=11
                     /translation="MNVCTKCGTHFEDSVQFCQNCGTKRRDPVVKKQKMSKGTIIEITL
                     LTFFIIVLGGLYAYGSSYYSQSSQVERIITVLQERDGEKLVEITTTDDPAVIVTRESLT
                     PLFSYIKENPSYVNELKEYLRQGEKQGDGIERADFSLTKDGKHFFLFDRYKLKAKTYYT
                     TLLTNEKGTSLKLNGKEIDKTNDKKLEKQYGPFLPGTQVFQSEYKNDYVKLSREEKVVL
                     MKQIQNNVTIDLTLQGQYITVQTNAPGATLYVNQKPVTALTGEEITWGPIATDGSAAIY
                     LERNGENGRETTKVETVTALSAYNLPFQKKSVEKTVVYNVTPPTTGYVYNGFIFPDSDI
                     RKLTSADLTYLSKEQLKIARNEVYARHGHVFQTKDMQAYFSKQSWYRENPYFTGTLTSV
                     ESYNVELIKSRE"
     gene            complement(6753..7181)
                     /locus_tag="I6L50_RS12590"
                     /old_locus_tag="I6L50_12590"
     CDS             complement(6753..7181)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135033.1"
                     /locus_tag="I6L50_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12590"
                     /product="hypothetical protein"
                     /protein_id="WP_215587471.1"
                     /transl_table=11
                     /translation="MCAGLLVQLPEEPIEPRPALPLEQEFTVSVTLYSARAWLSDNDTF
                     SQTIWKSTRFASASHARKSIFPVGTVKIVNFSEDTITVTISSESDDALKIVVPPRSEAA
                     LTSSSLSDVQASTSGGASKVTFLFHIFFSRDPGPAKQP"
     gene            7381..8715
                     /locus_tag="I6L50_RS12595"
                     /old_locus_tag="I6L50_12595"
     CDS             7381..8715
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="I6L50_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12595"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_219301742.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.8e-62, bitscore:
                     208.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDETANVVTLEKGEIYSYAQCGLP
                     YVISGVIASTEKLIARDVKTFRDKYGIDAKVRHEVTKIDTEKKMVYAEHTETKDVFEFP
                     YDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEAVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEHIHKEADKHNIEILTNENVKAFKGKER
                     VEQIETDKGTYKTDLVLVSVGVQSNTDFLEGTNIRKNHKGAIEVNAYMQTNVKDVYAAG
                     DCATHYHVIKEMHDHIPLGTTANKQGRLAGLNMVDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLNIPYKTVKVDSTNMAGYYPSASPLHLKLLYHADTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            8875..9285
                     /locus_tag="I6L50_RS12600"
                     /old_locus_tag="I6L50_12600"
     CDS             8875..9285
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="I6L50_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12600"
                     /product="DUF3908 family protein"
                     /protein_id="WP_002030461.1"
                     /transl_table=11
                     /translation="MAINMNTIEEWIAESNARNEEDLGNVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVFFFFQDHVVIGEEKEEYIEIEKLKYDDITNSNLKTNDKNTTLELKFS
                     NGKAINLDSLNDNYGTKNWLFARQIKSIFKVI"
     gene            complement(9318..9908)
                     /locus_tag="I6L50_RS12605"
                     /old_locus_tag="I6L50_12605"
     CDS             complement(9318..9908)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (48-149). E-value: 2.6e-14. Score:
                     44.1. Matches aSDomain: nrpspksdomains_I6L50_RS12605_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002158829.1"
                     /locus_tag="I6L50_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12605"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_219301743.1"
                     /sec_met_domain="PCMT (E-value: 9.3e-05, bitscore: 20.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSILQRLIEQAKNPRGTIGSSMLCIMNAAHTRLTNWALQKIHIRE
                     NAVILDIGCGGGKTIQTLSKRTPLGKIYGIDYSNQAVENSKKANMKDVKAAKVIIHQAS
                     VSSIPYHPDFFDLITAFQTHYFWPDFEHDMKEVFRVLKPNGSFLLVAETFKIQYHMDKF
                     KTTEELVNLFYKTGFTNVKCYEERGCLCLIGNK"
     aSDomain        complement(9462..9764)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6L50_RS12605_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.60E-14"
                     /label="I6L50_RS12605_oMT.1"
                     /locus_tag="I6L50_RS12605"
                     /protein_end="149"
                     /protein_start="48"
                     /score="44.1"
                     /tool="antismash"
                     /translation="ILDIGCGGGKTIQTLSKRTPLGKIYGIDYSNQAVENSKKANMKDV
                     KAAKVIIHQASVSSIPYHPDFFDLITAFQTHYFWPDFEHDMKEVFRVLKPNGSFLL"
     gene            complement(10001..11563)
                     /locus_tag="I6L50_RS12610"
                     /old_locus_tag="I6L50_12610"
     CDS             complement(10001..11563)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135039.1"
                     /locus_tag="I6L50_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12610"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_219301744.1"
                     /sec_met_domain="PF00881 (E-value: 5.9e-10, bitscore: 37.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPDTFLHHLHFSINEIMSSDKEINWEDAPLPYKLYRNLPVIPLS
                     LKIPLTSRNSSTKPNLEEIGHYLWYSFGLTQLCQPTTNLENNKTTTLFRRFIPSGGALY
                     PNELYMYLKIDHYPDGIYHYDAAHHRLILLREGNFDSYLTEALGNRCNIHSCFGAAFVS
                     TMFWKNFFKYNNFSYRLQGLDSGVLIGQLLECAKQFGYTNGVYFQFLDRAMNHFLGLSE
                     GEESVYAVIPLSTEPNTDWFHDDHRKNKTITSHDLLQQIPPLTHEHFVRSKHVDDYPMI
                     KKINASSMIESTEHFQTFTCEERQQYSAHAMQLPKVERLSYDFLQLCKKRYSPDSDFIL
                     TKWDAAELATLLQEASLSFPYYNDLDGKYLNENARVSLYGCFYNVKDIENGAYAYNSRT
                     HSIQPLRYGDLRYSLQSSMTMDNVNLFQVPLCLHVIGNKDYYKNKLGYRGYRIHQMEAG
                     MLVHKLVLAATAMGMGGHPLLSFDTNSCDQLYGIDAGNETSLIQIPVGAYRARNWLKGS
                     LHN"
     gene            complement(11586..13535)
                     /locus_tag="I6L50_RS12615"
                     /old_locus_tag="I6L50_12615"
     CDS             complement(11586..13535)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="I6L50_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12615"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_219301745.1"
                     /sec_met_domain="YcaO (E-value: 2.6e-84, bitscore: 281.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.7e-140, bitscore:
                     463.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQNILLIGDGLLTDYVHEQLCKQYSLIRQHTITEALPENIHLAL
                     VLHDGSPSSVHHDAELIFRSNNIPWLRAFTSFGEGIIGPYVKPLTTGCSHCADGRRFIA
                     GFDQREMWELQRKYALKAENVTRRDVRATQNGMLQMCQLIHAETEKILAHGYSSLENEL
                     ILLDLQTLQCTRNSFLPDPLCPVCSNLPDDTADAAQISLQPSLKTSTETYRCRSIHELN
                     TFLTRDYLDYRTGILNGQMQHSLLPFADVIINMPLLFGNEGVAGRTHSFSLSEATAILE
                     GLERYCGMSPRGKKTNVHGSFRELEDVALNPLTLGVHTNEHYNRDSFPFKPFDPDYEQN
                     WVWGYSLLQSRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIERLRTITGYELYVFNATMEHGIPSIWVIAK
                     NTRQDGMNLVCAGGAHMEPIRAVKNAIHEIAGMLLITDEELEQKREKYENCLQDPYLVS
                     QMEDHSMLYGLKEAEERLHFLLREDAPVQTFQEMNALQSFDMDLTSDLHQLLNRLHQSG
                     LEVIVVDQTVPLIEKNGLHCVKVIIPGMLPMTFGHHLTRVTGLDRVYTVPMTLGYWAEP
                     LTNESLNPHPHPFP"
     gene            complement(13532..15451)
                     /locus_tag="I6L50_RS12620"
                     /old_locus_tag="I6L50_12620"
     CDS             complement(13532..15451)
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="I6L50_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12620"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_219301746.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1164.0,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     1.2e-54, bitscore: 180.1, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2e-11,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPVHAKLKANKDTFFLPDSNGGVYFRNNSSSFRMDGDGIYDW
                     IEKLMPMFNGNHSLTEITDGLPLPYQNRVFEIGEILYENGFIRDVSQDAPHELTSALLD
                     RYASQIEFLEADSHSGALKFETYRAANVLIIGSGDMLTSLVSSLLESGLPTFHYLVTDR
                     AETNYDRIHELSERAYANDDNVLIQEIDITIDRPLHEVFEPFDWILYVSQNGDIESLRA
                     IHTICREFKKNFIPAICLSRIGLAGPVVTVDREECWESAWHRLHETTLQSENPPEPFSP
                     IASAMLANVIVFELFKHVAEDSHRQHNPQFFLLNLETLEGKWHPFIKHLLATDEIFTID
                     TVQNLQENLAQRSGQYTSTELFRFFDTLTSKEAGIFHMWDEQDLHQLPLSQCNIQVANP
                     LSDGPTSPLPTITCGGLTHNEARREAGLTGVETYVAEMIHRLIPEHTDIGIGAGETMTE
                     GVYRALQKHLNNKLYERQSHMLEEITELYLTEIHDKHCRFYYDALSTIHEIPKVGMSEE
                     LLGFPVVWIGINDRWYGAANINITLALRNALQQALLHIQNEEIPYKANMLPESSIVLYS
                     TDSVRVAIQEEEEIPGVQSLQVALQNLAENNLYPFVFDLAIESFLRDSLDGVYGVLIAK
                     EDDQ"
     aSDomain        complement(15155..15451)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I6L50_RS12620_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="8.50E-57"
                     /identifier="RREFam011.1"
                     /label="I6L50_RS12620"
                     /locus_tag="I6L50_RS12620"
                     /protein_end="99"
                     /protein_start="0"
                     /score="180.1"
                     /tool="antismash"
                     /translation="MNNLPVHAKLKANKDTFFLPDSNGGVYFRNNSSSFRMDGDGIYDW
                     IEKLMPMFNGNHSLTEITDGLPLPYQNRVFEIGEILYENGFIRDVSQDAPHELT"
     aSDomain        complement(15185..15424)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_I6L50_RS12620_Thiopeptide_F_RRE.1"
                     /evalue="1.50E-13"
                     /identifier="RREFam004.1"
                     /label="I6L50_RS12620"
                     /locus_tag="I6L50_RS12620"
                     /protein_end="89"
                     /protein_start="9"
                     /score="41.5"
                     /tool="antismash"
                     /translation="LKANKDTFFLPDSNGGVYFRNNSSSFRMDGDGIYDWIEKLMPMFN
                     GNHSLTEITDGLPLPYQNRVFEIGEILYENGFIRD"
     gene            15718..17187
                     /locus_tag="I6L50_RS12625"
                     /old_locus_tag="I6L50_12625"
                     /pseudo=""
     CDS             15718..17187
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159708.1"
                     /locus_tag="I6L50_RS12625"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12625"
                     /product="RNA-guided endonuclease InsQ/TnpB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTKENPSNYKTLQIWIKKGHRMYSYFQECCHNAKNMYNTTNFYIR
                     QVYTGLTQEKELQPLQKEVLDNIHKNIGKMNDTQLLAYQKKLEKEKLKPKEEQKEIKCN
                     LFSEPNFEKPYVDYNFLDALFKAMIQNDYRALPTQCSQSIMKGLFQN"
     gene            complement(17241..18497)
                     /gene="odhB"
                     /locus_tag="I6L50_RS12630"
                     /old_locus_tag="I6L50_12630"
     CDS             complement(17241..18497)
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="I6L50_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12630"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_219301747.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESISEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAAVAVSTPAPPAEQPKQETTEAPKA
                     AAPSAEQNKALQGLPNTNRPIASPAARKMARELGIDLNEVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKQSPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVDM
                     SAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYDI
                     GIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGLKARDNKLSLKELQGGTFTITNGGV
                     FGSLMSTPILNSPQVGILGMHQIQVRPVAIDAERMENRPMMYLALSYDHRIVDGKEAVS
                     FLVAVKDMLEDPKSLLLEG"
     gene            complement(18627..21494)
                     /gene="odhA"
                     /locus_tag="I6L50_RS12635"
                     /old_locus_tag="I6L50_12635"
     CDS             complement(18627..21494)
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="I6L50_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12635"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_219301748.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLIEKTMNELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERTWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVSEGAKGGVEDVMIGMAHRGRLSVLAHVLEKPYNHMFAEFKHAKIEGAV
                     ANAGWTGDVKYHLGREQVVGNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPEQDTTKSFVILVHGDAAFPGQGVVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRTLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQSAGVLNADEVETITQFIQEELKAEYA
                     QVPPADTSAATIHVKVPEVVAKGIQPIDTGVSIESLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGT
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYSLDEVHMVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKQEIEVFSN"
     misc_feature    22142..22162
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 30.06"
                     /tool="antismash"
     misc_feature    22194..22208
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.18"
                     /tool="antismash"
     gene            22321..22530
                     /locus_tag="I6L50_RS12640"
                     /old_locus_tag="I6L50_12640"
     CDS             22321..22530
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428510.1"
                     /locus_tag="I6L50_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12640"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428506.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEEGE"
     gene            22533..22910
                     /locus_tag="I6L50_RS12645"
                     /old_locus_tag="I6L50_12645"
     CDS             22533..22910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="I6L50_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12645"
                     /product="hypothetical protein"
                     /protein_id="WP_002140897.1"
                     /transl_table=11
                     /translation="MNYSQKYFVIMGIIFLFMSGFMILTGIMTHSAPPAPTYTLLAMMI
                     MCFCLSYLHPQFKEKDERMKLIRYKGMFFSFFALTAYYLLFSFGLNLKIITLSATELLN
                     ILMALTMSTVFISFVVLSKRY"
     gene            22939..23121
                     /locus_tag="I6L50_RS12650"
                     /old_locus_tag="I6L50_12650"
     CDS             22939..23121
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="I6L50_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6L50_12650"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_002086895.1"
                     /transl_table=11
                     /translation="MQMMYAFGMGLVLFLAVFLFIRKDVQGGTLTKRGFYKMIGCLVVM
                     FIAIIVMIVLINQSL"
     misc_feature    complement(22949..22964)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.85"
                     /tool="antismash"
ORIGIN
        1 ttatatggaa gaggtgtaaa aaatgggagt agaaaaaatt atagcagcgt ttgaaaatgg
       61 caagaaagca tttattccgt atgtaatggg cggagatggt ggacttgaaa agttaaaaga
      121 aagaattcgt tttcttgatg aagcaggagc aagcatcgtt gaaattggta tcccattttc
      181 agatccagtc gcagacggtc caactattca aagggcagga aaaagagcat tagatagcgg
      241 tgtaacattg aaaggtattt ttcaagcatt aatagaggtg aggcaagaag ttcaaattcc
      301 atttgtactt atgacatatt taaatccagt actcgcattc ggaaaggaac gtttcattga
      361 gagctgtctt gaagcagggg tggacggtat tatcgttcca gacttaccgt atgaagaaca
      421 agacattatt acaccgctcc ttcgcgtggc gaatatcgct ttaattccac tcgttaccgt
      481 aacgagccct attgaacgaa tcgaaaaaat tacgggtgaa tcacaaggat tcgtctacgc
      541 cgttacagta gcgggtgtaa cgggagtacg tcaaaacttt aaagatgaga ttcgtagtta
      601 cttagaaaaa gtaaaagcac acgtccactt accagtagtc gcaggattcg gtatttcaac
      661 acgagagcaa attgaagaaa tgattacaat atgtgacggc gttgtcgttg gaagtaaagt
      721 cattgagctg ttagaaaatg aaaagcgaga agaaatttgt gagttaatac atgcagtaaa
      781 agaaacagaa gaggcttaag tctcttctgt ttcttttgtg taataaatgt taaaatatac
      841 agaaaatact tataacttag agggtgagaa ggcatgctaa gacgtaaact attatatctt
      901 cttttaactg taccattata cgcttggctc attagcatga cgaaaataga gttgatggct
      961 ctgtttttag gatatgtatt catcttttcc caattaaatc gaatacaaga gcaatctatt
     1021 ttagaagtat gtatattttc ggttagtata gaactattta gtatcgttgc gattgtatta
     1081 ttaagtgaat tattccaatg gatccattca tttgaattaa taaaacttgg gaatattgta
     1141 ttgcaagtaa tatgtgctta tattgtgttt gttgtgctag aaaaaatgat tggacagcag
     1201 acggtttttc aggataaaag ataaaatatt agttattcaa aaaaaggagc caagcggctc
     1261 cttttttaaa tctgttataa aaataattga aaatcataac atctgttata taatagttaa
     1321 aaattgcact ttttacgaaa agagatgata gcatggccat attgttggca cttatcccga
     1381 ttatgatgat ttttatttgt ttgtttttgt ttaaacaaac gtcattaaga gcctcattaa
     1441 tctcttatgc cgtttctgtc ggaatcgttt tactctcgcc aacgtttcaa ttagggataa
     1501 gtgaaactgt acacgcaaca attaaagggt ggttaatttg ttttattgtc ggatacgttt
     1561 tatttttcgg tattttttta tttcacctca tgaacaaaat gggatacatc gatcaagtag
     1621 cacgatttct agaacaagtc acgcgcgatc gattattgca aatgcttctt atgtgttttg
     1681 gtatttgtcc acttattgaa tcagtgagtg gattcggaat tggttttatg gtcgcagcac
     1741 ctatttttct ttcgctcggt tataaaccgt ttcaagctgt gctactatcg tttatcggtt
     1801 tacttgcaag ttcatggggc gcaatggcaa cgggtacgat tatcggttct cagcttatta
     1861 acatgccgct cacaactctt ggtacaaata cagcattatt aagcatcccg attttcgcat
     1921 attttatctt cctttcttta tacgttgtcg gtggctggca ggcagttata gaaaagtgga
     1981 aggaagggat aggattcttt ctattatttt ctctcggaat ctatctttct aacgcatacg
     2041 taagtgttga actagcaggg atattaagtt ctatcgttac catttcattt ggttttttaa
     2101 tcattaagtt aaaaggaaaa gatgagcaaa accttttaac agaacatgcg gcggctacgg
     2161 agagagaagt atcgattata aaaattatta gcccttatat attcttaaca gtttgtattt
     2221 tactttctcg cctcgttcca gcattacatg attttcttag gtcatatgca gttctcgatt
     2281 taaaatcata ttcttacaaa ctagagctac tatattcgcc aggattttgg ctcgccatga
     2341 cttgtttatt tacaattatt ttcttccgca ttccatctaa tgttattaaa caatcactct
     2401 cgcaaacgac aaaacaatgg attcctttcg ctattacaac gacgatgttc attgcaattt
     2461 cagaactaat gggtgcatct ggtatgcatt cattactcgc aaaaacagct ggtgaaacct
     2521 ttggtacctt tttcgttttc gttgctccat tcataggcgg aattggcggt tttttaactg
     2581 gtagtaacgc aggatcaaat gcgatgttta taaagctaca aatgcaaaca gctcaaaacg
     2641 tagcactccc gtggcaatac gtcacgacgc tccaaaacac cgcatcatca gtagcgacga
     2701 tcgcttgtcc atcacggatt acactaggcg cgtatttatg caatatcccg tatcgtgaaa
     2761 atgaactatt aaagaagacg acgttaatga tttttggtgc ggttttactt gtagtagtgg
     2821 aagttttctt ttggtatata ttgagaaatt aaaaatcctc ctaacatagg aggattttct
     2881 ttatgactgg ataatgtttt aaatatgaaa agcttctact aaatgaatag gagatgaaag
     2941 gtatgccctt aaaaaactac ggtgtattaa aaggtacagt tatacaatct aagattggaa
     3001 aaggcaaaac acctcattat caagttcatt tacaaggtga agcaggagta gattatcgca
     3061 ttgcaattaa cgtgaaatcg caaagttatc catcggaagt tttatatttt gcgagcgacg
     3121 atattcgatc agaggcgatt catattttac cgacattacc gttcggtttt acagaaataa
     3181 aaaataatga accgaaagta gctttagatt atgtaagagg taatttattt gattcaaagc
     3241 aaatgattcc tttacctgct gaaaaagcag gagttgataa tgatttaaat gaaaagatag
     3301 agcgttatat aaagcgagca atagaagaaa aggcgattat ttatgcgttt ggtgaaaggt
     3361 ggggaccaga agaaaaggtt ccggattcgt atttccactt tacacctgga aacggtatac
     3421 acgatattca tatgaatcaa gggaatgtag agaaatggca aggtgatgat ggcaaatggc
     3481 aagacggtgg gatattgatt cactttgaga agaaggaaga gtggattggt atttttcttg
     3541 cctttcagtc acagtcatgg tgtacggatg aagaagggca tgctcgtgtt ccggttgagc
     3601 attgtgatta taagagaaat aattgatggg aagagggcgt tcacaatgaa cgccctcctc
     3661 ttattttata aaacacaaaa ctcacaagtg tagaaataca agagaaaaga agcgccacac
     3721 tagaaaacgc aatgagatac atattatact tcatcatttt tccgatgagt tggttactat
     3781 cgtactgaaa aagtcctgca attatattga ataaaaataa catgataaac atgacgataa
     3841 caccgtctat tgatccttta atgtcgggtt tacttaaagc gatatgtgca gaaatacaaa
     3901 tggcgataaa taaaaataac caaaatgaag gattcaataa attgttaaat gtaaataagc
     3961 ttttcaataa tacaaacgtc gatagtagca tgttttggat catgtctaag ttaatagaag
     4021 tcgatgcaac agttttttcc agattcgtat taaataaata atatgactct ggtacgaaat
     4081 agcgcattaa aagtattaag gcagtaatac cagaaataat aggaccgatg ccgataaaga
     4141 aattaccgat ccgttgatat acgctttttt gattgtattg atgttgtacg taacctaaag
     4201 ctccttgact tgtatctgtt gggaagaact gcgttgctac aattttatgg cggaataata
     4261 gacacataat tgcatgtcca agctcatgaa cgggaacacc aatccacgca gttaaaagaa
     4321 atcccttcct accaaaagct ctcgaccaat acgttcgtgt gagagattct aaataaccta
     4381 atataaatcc aattacaatg atgacaccaa ttaaagaaaa taattggatc acgcttgtaa
     4441 ggagtgtttg aaaaatcgag tttacaaatt ccactgtctt catccaatct gtttaaagtt
     4501 tcactttatt tgctctgttt cataatacca ttatttttct ataatactag cacacatagt
     4561 ttcgtttaaa agaaggattt catattcttt ttcttgtagt catgttttat gtacaaagtc
     4621 atatattgaa tttgtaacat cctataaggt atatgcttaa ggagggatga gagaatgaaa
     4681 tgtccggcat gtcatactga aaatgcagcg gaagcaaggt tttgcgggaa ttgtggacat
     4741 tcgttaacgg aagaagtggt agcgagtggt gggcaggaag aagggcagct atcgcgcccg
     4801 gcacgagtaa aggaaactcg tccgaatgaa acggtagagc aagcgaaaca atttgcaagt
     4861 ggctattttc agttctttaa aaatgctttt aaatcaccat cggccattat ggaaagtgga
     4921 aatattgaag tgcgaaatgg aattgtaagt cttgtgctta tttgtttttt aggagcgtgt
     4981 attttttata gaatgatgag cgcagcggcg actgttacga ggacattagt gccagatata
     5041 gctactccta ctttctttgg agaatctgta atggtctttt tctttttatt aattttaact
     5101 ttatttgtcg gatttattat ttttgtaagt ggtaagatga tgaaatcatc tttttctttt
     5161 cttgaagcat tcggtatatg ggggacgata gcgacgccag ctattgctat attagtgctt
     5221 tcttttcttt ttagtttttt attaatcttc ttcttaccaa tcttattagg gctggctaca
     5281 acgtatatgg gaattagtat aattgtagct atattaaaac tagacaacgg cagattagat
     5341 cctgtttaca cacttatgat tgcaagtgtt ttaatcggaa ttgcaacgtt tcttgtattt
     5401 tggtcttaca ttaacacgat aattcaaacc tttactgggg gattaacagg cttctaatga
     5461 aaaggtggtt gaatggatga atgtatgcac aaagtgcggg actcattttg aagacagtgt
     5521 gcaattttgt caaaactgcg ggacgaagag gcgggatcct gtagtaaaga agcagaaaat
     5581 gagcaaaggg acaataattg aaattacact tttaacattt tttattatag tattgggcgg
     5641 attatatgcg tatggatctt catattactc acaatcatcg caagtagaga gaattattac
     5701 tgttttacaa gagagggacg gggagaaatt agttgagatc accacgacag atgatccagc
     5761 cgttattgta acgagagaga gtttaacgcc tctattttca tatataaaag aaaatccatc
     5821 ttacgtgaat gaattgaaag aatatttgag gcaaggtgaa aaacaagggg atggaataga
     5881 aagagcagat ttttctttaa cgaaagatgg gaaacatttc tttttatttg atcggtataa
     5941 attgaaagcg aagacgtatt atacgactct gcttacaaat gaaaaaggta catctttaaa
     6001 attgaacgga aaagaaattg ataagacaaa tgacaaaaag cttgagaaac aatatggacc
     6061 gtttcttcct ggaactcaag tatttcaatc tgaatataaa aatgactatg taaaactatc
     6121 acgtgaggaa aaggttgtac ttatgaaaca aattcaaaat aatgtaacga tagatttaac
     6181 gttacaaggg caatatatta cagttcaaac caatgcgcct ggtgcaacat tatacgtgaa
     6241 tcaaaagcca gttacagcat tgaccggaga agaaattacg tggggaccga tagcgactga
     6301 tggaagtgcg gcgatttatt tagaacgaaa tggagaaaac ggaagggaaa cgacaaaggt
     6361 agaaacggta acggcactgt cggcttataa tcttccattt caaaagaaaa gtgtagaaaa
     6421 aacagttgtt tacaatgtta ctccgcctac gactgggtat gtatataatg gtttcatctt
     6481 ccctgatagt gatattcgaa aattaacgag tgcggactta acatatttat cgaaagaaca
     6541 gttgaaaatt gcgagaaatg aagtatacgc aaggcatgga catgtttttc aaacgaaaga
     6601 tatgcaagcg tatttttcaa aacagtcctg gtacagagaa aatccgtatt ttacaggaac
     6661 gttaacgagt gtggaatctt ataatgttga actgattaaa tcaagagaat agagtgcatg
     6721 aaaaaggtac agtgtatatt actgtacctt ttctatggtt gtttagctgg accaggatcc
     6781 cttgagaaaa agatgtgaaa gaggaatgtg actttacttg ctcctcctga tgtacttgct
     6841 tgcacatcag ataaagaact agacgttaaa gcagcttcag aacgaggggg aacgactatt
     6901 ttgagtgcat catctgattc tgatgatata gtaaccgtta ttgtatcctc agaaaagttc
     6961 acaattttaa cagtaccaac tgggaagatg gatttgcgag cgtgtgaggc agaagcaaag
     7021 cgagtcgatt tccaaatagt ttgtgagaaa gtgtcattat cagataacca agcacgtgca
     7081 ctgtataaag ttacactaac ggtaaactct tgttcaagcg ggagggcggg tctcggttct
     7141 atcggttcct ctggaagctg gacgagaagg ccggcgcaca tgtatatttc acctactttc
     7201 aatagttgct gttatagcat attaaacatc ttgtttataa gacacgacgg atacctattc
     7261 atgcataggt ttgtgcacca aatttgtaga tagaattctc tttctttaca atggaagtag
     7321 gtgttatttc tataaaatat ggaaatcgta aagagtatgt aaaaaagaag gagtggtaaa
     7381 gtgaactatg tcattattgg cggagatgca gcaggtatga gtgcagcaat gcaaattgtt
     7441 agaaacgatg aaacggcaaa tgttgtaacg ttagaaaaag gtgaaatcta ttcatacgct
     7501 cagtgcggat taccgtatgt gattagtggt gttattgctt ctactgaaaa gttaattgca
     7561 cgcgatgtaa agacgtttcg tgataaatat ggaattgatg cgaaagtacg tcatgaagta
     7621 acgaaaatag atacggaaaa gaaaatggtg tacgcagagc atacggagac gaaagatgtt
     7681 tttgaatttc cgtatgaccg tttattaatt gcgactggag tgcgtcctgt tatgccagaa
     7741 tgggaagggc gagatttgca aggcgttcat cttttaaaaa caattccgga tgctgagcgc
     7801 atattaaaaa cgctagaaac gaataaagtt gaggctgtaa ctattattgg cggcggtgca
     7861 attggactag agatggcaga aacattcgtc gaacttggta agaaagtaag aatgattgag
     7921 cgaaacgatc atattggcac aatttatgat gccgatatgg cggaacatat acataaagaa
     7981 gcagataaac ataatattga aattttaaca aatgaaaatg taaaagcgtt taaaggaaaa
     8041 gagagagtgg aacaaattga aacagataaa ggtacgtata aaacagatct cgttttagta
     8101 tctgtcggtg tacagtcaaa tactgatttt cttgagggga caaatatacg taaaaaccat
     8161 aaaggtgcaa ttgaagtaaa tgcttatatg caaacgaatg tgaaagacgt atacgctgct
     8221 ggtgattgtg caacgcatta ccatgttata aaggaaatgc atgatcatat cccgcttgga
     8281 acgactgcga ataaacaagg gcgacttgcc ggactcaata tggttgataa acgaagagca
     8341 tttaaaggta cgttaggtac aggcattatt aaatttatgg atttgacgct cgcaagaaca
     8401 ggcttaaatg aaaaagaagc aaaagggcta aacatcccgt ataagacggt caaagtagat
     8461 tcaacaaata tggcaggcta ttacccgagt gcttcgccac ttcacttgaa attactatat
     8521 cacgccgata cgaaacaatt attaggcgga caagtaattg gagaagaagg tgtagataaa
     8581 cgtattgatg ttatcgcaat ggcacttttc aataaaatga gtattcacga tttagaagat
     8641 gtcgacttaa gttacgcacc accatataac agcgtttggg atccaattca acaagcagca
     8701 aggagagcgg aatagcactt ttttaagtgc tatttttttt gtgaaagggg aataaataaa
     8761 gtttcacttt attgtgaata taccgttcac ccttgaaaac atagtgcgta tcgcttatat
     8821 tgtcatatag tatttatttt ttaataaagc aatgaacgaa ccagggggca cagtatggca
     8881 attaacatga atacaatcga agaatggatt gctgaatcaa atgcaagaaa cgaagaagac
     8941 ttaggaaacg ttgttgaaga gatgaaagaa gtatgtgtcg gacttgataa cgcgacatta
     9001 atttatacga aaaacgtatt ttgtttcggt aagaaagtag aagtattctt cttcttccaa
     9061 gatcacgtcg ttatcggaga agagaaggaa gagtatattg agattgaaaa attaaagtat
     9121 gatgacatta caaatagcaa cttaaaaaca aatgacaaaa atacaacgtt agaacttaag
     9181 ttttctaacg ggaaagctat taatttagat agtctaaatg ataactacgg tacgaaaaac
     9241 tggttatttg caagacaaat taagagtatt tttaaagtaa tctagtaaaa aaggcaggcc
     9301 ttgaaaggtc tgctttttta cttatttcct attaaacaaa ggcatcctct ttcttcgtaa
     9361 catttcacgt ttgtaaatcc cgtcttataa aaaaggttta ctaattcttc ggtcgtctta
     9421 aatttatcca tatgatattg gattttgaaa gtttcagcaa ctagtaaaaa ggatccattc
     9481 ggttttaaga cgcgaaatac ttctttcata tcgtgttcaa aatcgggcca aaagtagtgg
     9541 gtttgaaaag cggtaatgag atcaaagaag tccggatgat atggaataga ggagacgctt
     9601 gcttgatgaa taattacttt cgctgctttg acatccttca tatttgcttt ctttgagttt
     9661 tcaacagctt gattggagta gtcgatcccg tatattttcc cgagcggagt tcgttttgaa
     9721 agagtctgta tggttttacc acccccacaa ccaatatcta aaataactgc attttcacgt
     9781 atatgtattt tttgtaaagc ccaatttgtt agtctcgtat gcgcagcatt cataatgcaa
     9841 agcatagagg aaccaattgt cccgcgagga tttttcgctt gctcgattaa tctttgtaaa
     9901 atactcaatt caaactctcc ttttatataa gaatatgtat ttatttcgct tttaataatt
     9961 taactccttt aaaaaaagca cgccattaat cggcgtactt ctaattatgc aaggaccctt
    10021 ttagccaatt tcgcgccctg taagccccaa caggaatttg aatgagtgaa gtttcatttc
    10081 cggcatcaat cccgtacaat tgatcgcatg aatttgtatc aaaacttagt aacggatgcc
    10141 cgcccatccc catagcggtc gcagctaaaa cgagtttatg aacgagcatg ccagcttcca
    10201 tttgatgaat gcgatatcct ctataaccta atttattttt atagtaatct ttatttccga
    10261 ttacatgtag acaaagtggt acttgaaaaa ggtttacgtt atccatcgtc atactagatt
    10321 gcagagaata acgaaggtct ccgtaccgaa gtggctgtat ggaatgtgtc ctactgttat
    10381 aagcgtaagc gccgttttct atgtctttta cgttataaaa acatccatat agtgagactc
    10441 gtgcgttttc atttaaatat ttgccatcaa ggtcgttgta ataagggaag gagaggctcg
    10501 cttcttgtag taaagtagcg agctcggctg catcccattt cgttaaaatg aagtcagaat
    10561 caggtgaata tcgtttttta caaagttgta aaaaatcata tgataaacgt tccactttag
    10621 gtagctgcat agcgtgtgca ctatattgtt gtcgttcttc acaggtaaat gtttggaagt
    10681 gttctgttga ttcaatcata gatgacgcgt ttattttttt tatcatcgga tagtcatcta
    10741 catgttttga acgaacgaaa tgctcatgtg ttaacggcgg gatttgctgc aacaagtcat
    10801 gagaagtaat ggttttattt ttacgatgat catcatgaaa ccaatctgta ttcggttctg
    10861 tacttaaagg aataacagca tacacacttt cttcaccttc tgacagtcca aggaaatgat
    10921 tcattgcccg gtctagaaat tgaaaatata caccatttgt ataaccgaat tgttttgcgc
    10981 attcaagtaa ttgaccgatg agaacaccac tatctaatcc ttgcagacga tacgaaaagt
    11041 tattgtattt aaagaagttt ttccaaaaca tagtggatac aaatgcagca ccaaaacaag
    11101 aatgtatgtt acaacgattg ccgagtgctt ctgtaagata agaatcgaaa tttccttcac
    11161 gaagtaagat aagacggtgg tgcgcggcgt cgtaatggta aatgccgtct ggataatgat
    11221 caatttttaa atacatatat aattcatttg gatataaagc acccccagaa gggatgaatc
    11281 ttcggaatag agtcgttgtt ttattatttt ctaggttagt agtaggctga cataattgtg
    11341 ttaaaccaaa tgagtaccaa agataatgac cgatttcctc taagttaggt ttagtagaag
    11401 aatttcgcga agttaatggg atttttaaag agagagggat gactggtaaa tttcgatata
    11461 atttataagg aagtggtgcg tcttcccagt taatctcttt atcggacgac ataatttcat
    11521 taatagaaaa atggagatga tgtaaaaaag tatcaggttg catcaaattt ccccctcact
    11581 atgaattatg gaaacggatg cggatgtgga tttaaacttt cattcgttaa aggctcagcc
    11641 caatatccaa gtgtcatcgg tacggtatac actctatcca gtcctgtaac ccgagtgaga
    11701 tggtgaccaa acgtcatcgg taacatgcct ggaataatta cttttacaca atgtaagccg
    11761 ttcttttcta taagggggac cgtttgatct acaacaatta cttcaagtcc agattgatgt
    11821 aacctgttta aaagttgatg aagatcagat gttaaatcca tatcaaatga ttgtaatgca
    11881 ttcatttctt ggaacgtttg caccggagca tcttcacgta aaaggaagtg aagacgttct
    11941 tccgcttctt tcaatccata cagcatacta tggtcttcca tttgcgaaac aagatatgga
    12001 tcttgtaaac agttttcata tttctctctt ttttgttcaa gctcttcatc tgttataagt
    12061 aacatgcccg ctatttcatg aattgcattt tttacagctc gaattggttc catatgtgcg
    12121 ccgccagcac agacgagatt cataccatct tgccttgtat ttttcgcaat gacccatatg
    12181 ctcggaatac catgttccat cgtcgcgttg aaaacgtata attcatatcc agtaattgtg
    12241 cgtaagcgtt caatcattaa ttgcaattca gtatcattgg ctgaactaag atcgagacgg
    12301 ggaagaggta attcggcata ccaagtgagc aaaaaggcgt cacgctctac aatttctaaa
    12361 atgccgtgaa aaattgcttc ttctaaacta ccaccaatgg cacatccatt tgatgtttca
    12421 tacacgaaag catctctatg accaaggcta taataagcga ttgattctgg aactagaagg
    12481 ggcctgcttt gtaataaaga atatccccat acccagtttt gctcataatc aggatcaaac
    12541 ggcttaaatg gaaaactatc acgattgtaa tgttcatttg tatgtacacc aagtgtgagg
    12601 ggattcagtg caacatcttc tagctcacga aaactgccat gtacatttgt tttttttcca
    12661 cgaggcgaca taccgcaata gcgttctaat ccttctaaaa tagcggttgc ttcactaagt
    12721 gaaaatgaat gagtccggcc cgcgacacct tcatttccaa acagtaacgg catgtttata
    12781 atgacatcag caaacggtaa taaagaatgt tgcatttggc cgtttaaaat accagtccgg
    12841 taatctaaat agtctctcgt taaaaatgtg tttagctcat gaatggaacg acagcgatac
    12901 gtttcagtac tcgttttcaa acttggttgt aaagaaattt gcgctgcatc tgctgtatcg
    12961 tcaggcaaat tgctgcatac cggacagaga gggtctggaa gaaatgaatt ccgggtacat
    13021 tgtaacgttt gtaagtccag taaaatgagt tcgttttcta aagaagaata tccatgagct
    13081 aatattttct ctgtttcagc atgaatgagc tggcacattt gtaacattcc attttgggtg
    13141 gcgcgtacat cacgcctcgt cacgttctct gcttttaatg catattttcg ttgtagttcc
    13201 cacatttctc tttgatcaaa gccagctata aaccggcgtc catcagcgca gtgggaacat
    13261 ccagttgtaa gaggcttcac gtaaggaccg ataatacctt caccaaacga agtaaacgcg
    13321 cgaagccacg gaatattatt tgagcgaaag ataagctcag catcatgatg tacggaagaa
    13381 ggagacccgt catgtaaaac gagagcaaga tgaatgtttt caggaagagc ttctgtaatt
    13441 gtatgctggc ggatgagtga atattgctta cacaattgct catgtacata gtctgtgagt
    13501 aggccatctc ctataagtag tatgttttga gtcattggtc atcctccttt gcaattaata
    13561 ctccatatac accgtctaag ctgtctctta aaaatgactc aatagctaaa tcaaaaacga
    13621 atggatacaa gttgttttcc gctaaatttt gcaaagcaac ttgtaaagac tgtacgcctg
    13681 gaatttcttc ctcttcttgt attgctactc taacagaatc cgtgctatat aaaacaatgg
    13741 atgattccgg taacatatta gctttataag gaatctcttc attttgaata tgaaggagtg
    13801 cttgttgcag agcatttctt agtgcgagtg ttatattaat atttgccgca ccataccatc
    13861 tatcattaat accgatccaa acgacaggaa aaccaagtaa ctcctcactc attcctactt
    13921 taggtatttc atgaattgta gagagagcat cgtagtaaaa cctacaatgt ttatcatgaa
    13981 tttcggttaa ataaagctct gtaatctctt ctaacatatg tgattggcgt tcatatagct
    14041 tattatttaa atgtttttgg agtgctcggt atacaccttc tgtcatcgtt tccccagcac
    14101 caataccgat atcagtatgt tcggggataa gacgatgaat catttcagct acatatgttt
    14161 caactcctgt taaaccagct tcgcggcgtg cttcattatg agttaatcca ccgcaagtta
    14221 tagtaggaag gggagaggta ggtccgtctg ataatggatt tgcaacttga atattgcact
    14281 gtgataaagg caattggtgt aaatcttgtt catcccacat gtggaatatg ccagcttctt
    14341 tagaagttaa cgtatcaaaa aaacgaaaaa gttcagttga agtatattgt ccggaacgtt
    14401 gggcaaggtt ttcttgaaga ttttgcaccg tatcaattgt aaagatttca tcggttgcga
    14461 gaagatgttt tatgaaaggg tgccactttc cttcaagtgt ttccaagttt aataaaaaga
    14521 attgaggatt atgctgccta tgtgaatctt cagcgacatg tttaaataac tcgaaaacga
    14581 taacatttgc taacattgca gatgcaattg gtgagaaagg ttcaggtgga ttttcacttt
    14641 gtaaagtagt ttcgtgtaga cgatgccaag ctgattccca gcattcttca cggtctacgg
    14701 ttacgacggg tccagctaaa ccaattcttg ataagcaaat agctggtatg aaatttttct
    14761 taaactctct acaaatagta tggattgctc ttaaactttc aatatctcca ttttgggaaa
    14821 cgtataaaat ccagtcgaaa ggctcgaata cttcatgtaa agggcgatca attgtaatat
    14881 ctatttcttg aataagtaca ttgtcatcat ttgcatatgc acgttcgctt agttcgtgaa
    14941 ttcgatcgta gtttgtttca gcacgatctg taacaagata atggaatgta ggtaaaccag
    15001 attctaataa agaagaaact agggaagtaa gcatatcgcc agaaccaatt ataagcacat
    15061 ttgctgcgcg gtacgtttcg aattttaaag cgcctgaatg ggaatcagct tctaaaaact
    15121 caatttgcga agcatatctg tcgagtaatg cactggttaa ttcgtgggga gcatcttggc
    15181 ttacatcacg aatgaaacca ttttcatata aaatctctcc aatttcaaat acacgatttt
    15241 gataggggag agggagacca tcggttattt ctgtcaaaga atgattaccg ttaaacatag
    15301 gcattaattt ctcaatccag tcataaattc catcaccatc catacggaat gaactggagt
    15361 tatttcgaaa gtaaacaccc ccgtttgaat cggggaggaa gaaagtatcc ttatttgctt
    15421 taagttttgc atgaactgga aggttattca tgtttatccc ccttacgttt taggcataca
    15481 ttgttagtct atgtagtgtg atttgtcccg tatgaacgca aaaaaagctg tagaatgatg
    15541 tattctacaa cctttatata ttagattatt aatctatcat gcctttcgag aggactccca
    15601 cctctaaacg taagcgaagg tggtgaggtg aatcgaaaga aatattttat tttcaagaaa
    15661 agagaggaag catacgttct cttttgctat aatatcctta acaaggaggt gaataaaatg
    15721 acaaaggaaa atccatcaaa ctataaaact cttcaaattt ggattaaaaa agggcatcgt
    15781 atgtattctt attttcaaga atgttgtcat aacgctaaga acatgtacaa caccacaaac
    15841 ttttatatac gccaggtgta cactggatta acacaagaaa aagagttgca gcctttgcaa
    15901 aaagaagttc tggataatat tcataaaaat attggtaaga tgaatgacac acaactcctg
    15961 gcctatcaga agaaattgga aaaagagaaa ttaaagccta aagaagaaca gaaagagatt
    16021 aaatgtaatt tgttttcaga acctaatttt gaaaaacctt atgtagatta caactttcta
    16081 gatgcactat ttaaggctat gattcaaaat gattatcgag ctttgcctac gcaatgtagc
    16141 cagtcaatca tgaaagggtt gttccaaaat tgaaaatctt tttttgctag tttaaaagac
    16201 tataaaaaga atccaaacaa atatgctgga atgcctagga tcccaaagta tattcgttct
    16261 tctgaaaaag agattctgta tacaaaccaa gattgcatca ttaaaaacgg tagattttta
    16321 aagtttccaa agacgaaatt acaattaaat attggcaaac taggtttcac tgaaggtaaa
    16381 ctgaaacaag ttcgtgtgat tccaaaatac aatgaatatg tagtggaatt ggtaattgat
    16441 gttccttctg aacaacaaat tattgaagag aatgctcgtt atatgagtat tgatttaggg
    16501 attgataacc ttgcaaccat cgtaacaaac acaggtatga aacctgtcct tgttaagggc
    16561 aaacatgtca aaagcataaa tcaatattac aacaaaatga agagtcattt tacaagcatt
    16621 cttagaaatg gaaaacaaac taatgaagga ccttttactt ctaaaaggat agaaaaactt
    16681 catcaaaaac gttacttgaa aataaaagac gtcttccata aagttagtca ccacatcgta
    16741 aaactagctc aagaagaaga agtttgtaaa atcgttattg gtcaaaacaa aagttggaaa
    16801 caagaaacga atatgggaaa aagaaataac caatcgtttt gtcatatccc gcataattta
    16861 ctgattcaaa tgattacata caaagcaaat gctgtaggca ttcaagttgt tgtaactgaa
    16921 gaatcatata catcgaaagc aagttttctg gataacgact tcattccaac gtatggagaa
    16981 aatgaccaaa atacaacttt ttcaggaaaa cgaataaagc gcggcatata tcgttcagca
    17041 aataaaactt taattaatgc agatgtaaat gctgcggcta acattttacg aaaagtaatc
    17101 ccaaatgcat ggacaaatgg gatagagggg ttaggcgtga aacagctcgc taatgtgtta
    17161 actcccttga cgttaatcgt ccgttaggtc gaaacgttag aaacccccac ttcaagcttt
    17221 gctaagtggg ggagtgttca tcaaccttct aataataatg attttggatc ttcaagcata
    17281 tctttaacag caacaaggaa gctaactgct tctttaccat caacaatacg gtgatcgtaa
    17341 gatagtgcaa ggtacatcat tggacggttt tccatacgct ctgcatcaat tgcaactgga
    17401 cgtacttgga tttgatgcat ccctagaata cctacttgtg gactatttag gattggtgtt
    17461 gacattagag aaccgaacac gccaccattt gtaatcgtaa atgtaccacc ttgtagctct
    17521 tttaatgaaa gtttattatc gcgtgctttc agacctaaat tacgaatctc gctttcaatt
    17581 tcagcgaagt tcaattggtt agcatcgcgt acaactggaa caactaatcc atctggagct
    17641 gctactgcaa taccgatatc atagaatttt ttaatgataa gctcatcgcc ttgaatttca
    17701 gcatttaata atgggaactg ttttaatgct gcaacaactg cttttgtgaa gaatgacata
    17761 aagccaagac gtacatcatg ttttttctcg aaagcatctt tgcgttcttt acgtaattcc
    17821 atgattgcac tcatatcaac ttcgttaaat gtagttaaca ttgcagatgt ttgttgaact
    17881 tctacaagac gttttgcaat tgtttgacgg cggcgggaca ttttcacacg ctcaactggt
    17941 ttttcaaatt cagtttttgc aactggagcc ggactttgtt ttggagcagc tggtgcttct
    18001 tttggcgctg cagcgtgagc ttgtacgtca tgtggtctca cacgtccaag tggatctgtg
    18061 ctacgtactt cgtttaaatc gattcctaat tcacgagcca ttttgcgagc agctggtgat
    18121 gcgataggac gatttgtatt tggtaaacct tgcaacgctt tattttgttc agcacttgga
    18181 gctgctgctt tcggtgcttc agtagtttct tgttttggtt gctcagcagg tggtgctggt
    18241 gtacttactg caactgctgc gccgtttgca tctaaaattg cgatagtagc gccaacttca
    18301 actgtatccc caggttcgcc tagtaacttc gatacaatac ctgaatcctc tgcaatgatt
    18361 tctacattaa ctttgtcagt ctcaagctca acaacgctgc cacctttctc aactttgtcg
    18421 cctacgttga taagccattg tgaaatagtt ccttctgaaa tagattctgc aagctcaggt
    18481 actttaattt cgatcatttt aaatgtcctc cccttatttg cctaacggtg tgttttgtct
    18541 tctttaatcc tcggtaatct ccatttgtta gcctggctgt ggcagactat ctgccacagc
    18601 caagcctgaa aaactcattg ttactttcag ttgctgaaaa cttcaatttc ttgtttatct
    18661 tgacggaagt tgtacttcac atctaaagcg tgtgcaacga ttaattcttg ctcagctttg
    18721 tgagcgaatg gatcgccacc agatgggcta gaacgatccg ggcgtccaat gtaacctgtt
    18781 ttcactttat ccccagctag ttcgaacaga attggagcca tgtaatgcca tgcgcccata
    18841 ttacgaggtt cttcttgaac ccaaatgatt tcttctaagt ttttaaagcg tttaataata
    18901 gattgaactt tttcagcagg gaatgggtac aactgctcga tacgaaccat atgaacttca
    18961 tctaggctgt actcatgctt accactttcg atttctgctg ctaagtcaat tgccatttta
    19021 cctgtactta aaacaagacg ttttacttta tttggctttg taccaaggtt ttcttgttct
    19081 aaagcaggtt ggaaacgtcc ttcgcttaac tgactagcag ttgaaagcgt aagtggatga
    19141 cgtaataaac tctttggcgt cataagcact aacggtcgaa cagcttctgt tcctaggata
    19201 gatgcttgac gacgtaaaat atggaagtat tgtgccgcgc tcgttaagtt tgcaactgtc
    19261 cagttgttct cagcagctaa ttgtaagaaa cgctctggac gtgcactaga gtgttctggc
    19321 ccttgacctt cataaccgtg tggtaataga agaactaaac cagatttttg accccatttc
    19381 gctcttcctg ctgaaacata ttgatcaaat aatgcttgcg cagtatttga gaagtcaccg
    19441 tattgagctt cccacataac aagagtttct ggagcaaata cgttgtaacc atattcgtaa
    19501 ccaacaacag cagcttctga taacggactg ttatgaacag agaatgatgc gttaatgttc
    19561 ggtaaacggt gtaatggtga atatgtttcg tttgtatcag tatcgtgtaa tacgatatga
    19621 cggtgcgcga atgtaccacg ctgtgaatct tgaccagtta aacgaattgg cgtaccttct
    19681 tgcaaaatag aagcgaatgc taacgattca gcaagtgccc attcaatttt accgttctct
    19741 tcaagagcat ctttacggcg ctcaagaatt ttcttcactt ttggatatac gttaaagcct
    19801 tcaggccaag ataatagtcc ttcattaatt gcacgaagtg attcaattga aacaccagtg
    19861 tcaatcggct ggattccttt tgcaacaacc tctggaactt taacgtgaat tgttgcagca
    19921 ctcgtatcag ctggtggcac ttgtgcgtat tcagccttta attcctcttg tataaactga
    19981 gtaattgttt caacctcatc tgcattcaga acgccagcag attgtaattg atctgcataa
    20041 attgctctta cagttgggtg atttttaatt tttttgtaca cttgtggttg cgtaactgct
    20101 ggatcatcca tttcgttatg accatatcgg cggtaaccga ttaaatcgat taagaagtcc
    20161 tttttgaaca gcgtacgata ttggatcgca aggtttgcag cagcaagaca agcttccgga
    20221 tcatcagcat tcacgtgaac aatcggaata tcgaaacctt ttgcaaggtc gcttgaatat
    20281 ttagtagaac gagaatcata gctatcagtc gtaaagccga ctgcattatt tgcgataaca
    20341 tgaatagttc cgccagtttg gtatgcattc aatctactta agttgagggt ctcagacaca
    20401 acaccttgac cagggaatgc agcatcacca tgaactaaaa ttacgaatga ttttgtagta
    20461 tcttgttctg gaagaccaga ttttttacga ttctcttgag ctgcacgtgc gaaaccttca
    20521 acaacagggt taacgaactc aagatgactc gggttatttg ctaatgtaac acgagtgcta
    20581 acttcttcat taccaacgac ttgttctcta cctaaatggt atttcacgtc gccagtccag
    20641 ccagcatttg ccactgcacc ttctattttt gcatgtttga attctgcaaa catgtgatta
    20701 tatggctttt ctaatacgtg agcgagtacg cttagacgac cacggtgagc cataccaatc
    20761 atgacatctt ctactccgcc tttagcacct tctgaaacaa tttcatctag tacaggtaca
    20821 agcatatcaa cgccctctat agagaaacgt ttttgaccaa cgaatgtttt atgcaagaat
    20881 tgctcgaaac cttcaacagc agttaaacgt tttaaaagag cagttcgttt tttatttgat
    20941 aatggttgac gcaatgaatt tgattccacc atttgatgca accacgtgcg ttcttcacta
    21001 tcttgtatat gtgagaattc ataagctaaa gattttgtat aaacgtcttt taatctatga
    21061 attacatcaa gtgcagtgtg aataccctct ggtgcatctt gccatactgt ttttgctggg
    21121 atcgctttca agtcagcatc gctcagttcg ttcattgttt tctcgataag agattgtccg
    21181 tttgcagcat cttccatcgg attaatgtga gccaatgtat gcccgaaaga acggatttgt
    21241 tcaacaagtt gaacgacttt aagaatcttt tcaatgttcc ctgtgttttg aggagaaaaa
    21301 tgtgttgctg tgttgtcccc tgttacgaca tcatcttgaa acgaaggagc tccaaaaatt
    21361 tcaaaaagct cttgtaattc cggatcaaca gaacctgctc cagttacgta aagatcatac
    21421 tgttcaataa cataaccaag gttcggacca tggaacttgg cccaagggtt tgtcgttgta
    21481 ttcttcctcg tcatttgttt aaacctccca atgcatataa tcctttttcc atacaaaaag
    21541 gtgcattttg ctcttttcaa taattgatga accaataatc aatgtaaatg tttttcttta
    21601 ctcttatgtt attacaataa tttacataat accaaacact attacttatc tgttttgtaa
    21661 aaaaacattc acaataactt atcacccaag ttaatctttc atgttataaa gtaatttcac
    21721 gggaaaatgg ggtggatata tttggtatac ctacattaat acctataatt gttgcattta
    21781 aatataagta taactatcag aatgtttcga taaagtttag ttcgaattat gtatattgga
    21841 ataataagcg ctttcattga tattatacaa caatataacg gaatatagta taaaaaataa
    21901 aaaattatga atttaccata aactttatct cgatagtgtt aaatatcgaa aggaaaatga
    21961 aggatttcta caaaaaaagt ggctatacat aaaaaatgct tcataaaccg ttagtttcta
    22021 taaatatggc gaaaaacaac gtaaaaacaa tagcgcattt cacccgataa agagcagaat
    22081 gaaacatttt aaaaggataa aacaaatatg gagatattaa attttcataa aaacggggag
    22141 gagatatagt aacggctata tacattgttc catgtttcat ttcaaaatag acgtgctgaa
    22201 tttgaaaaag tttcttctat ataaatagaa tgaaaaataa acgaaatgaa tgtaaaggga
    22261 ccttgacgta aagtttcctt tacatatata ctcggtataa gggaggaggg agaaatttcc
    22321 ttggaaaata aaatggttga ataccgaaaa aaatttggac tatctcaaga aaaattggct
    22381 gagaaacttg gagtttccag acaaaccatc atttcaattg aaaagggaaa atatgatcca
    22441 tcacttccgt tagcatttga aatagcaaaa acatttcaga caacgataga acatgtattt
    22501 atttatgaag gaaaagaaga gggggaataa agatgaacta ttcacaaaag tacttcgtta
    22561 ttatgggaat tatttttcta tttatgagtg gatttatgat attaacaggt ataatgacgc
    22621 attctgcacc accggctcca acgtatacat tgcttgcgat gatgattatg tgtttttgct
    22681 taagttactt acacccgcaa tttaaagaaa aagatgagcg aatgaaactt attcgttata
    22741 aaggaatgtt cttcagcttt tttgcattaa ccgcatatta tcttcttttc tctttcggct
    22801 taaacttaaa aataattaca ctatctgcta ctgaactatt gaacatactt atggcactta
    22861 cgatgagtac agtttttata tcgtttgttg ttttatcgaa aagatattaa gatgtaaaag
    22921 agaaaggaag attaacatat gcaaatgatg tacgcttttg gcatggggct tgttttattt
    22981 ttagcggtat tcttatttat tcgtaaagac gttcaaggcg gaacgttaac gaaacgagga
    23041 ttttataaaa tgatcggctg cttagttgtt atgtttatag cgattatcgt aatgatcgtt
    23101 ttaataaatc agtcactata gaatttaaaa atggaacctt acttttgtaa ggtttttctt
    23161 tttgaaaata aaactaaaaa ttaccataaa atccatttac tatctataat gagtattata
    23221 taatccaatg aaatgatagg taaggggaat agtatatgaa aaaaagctat cttctttata
    23281 ggagtatgtc tactacttat agctagtatt acttatataa tatgtaacaa acgagaacaa
    23341 gtgccaccta tgttagtagg ggagggccag gaatactacg ttacgaatga atctgcaaaa
    23401 gcagaagaag ttgggcaaaa agcctactaa agatagtgaa tccagcatat tagaagaaaa
    23461 aacagaagta tttgaaatga ttttagaaga agaggatgaa aggccaccta tactcgtaaa
    23521 agaacctaat agtga
//
