LOCUS       NZ_CP079819            21134 bp    DNA     circular CON 26-AUG-2024
DEFINITION  Rothia aeria strain LPB0401 chromosome, complete genome.
ACCESSION   NZ_CP079819
VERSION     NZ_CP079819.1
KEYWORDS    RefSeq.
SOURCE      Rothia aeria
  ORGANISM  Rothia aeria
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Rothia.
REFERENCE   1  (bases 1 to 2634007)
  AUTHORS   Kim,J.
  TITLE     Genome sequencing of Rothia aeria LPB0401
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2634007)
  AUTHORS   Kim,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUL-2021) College of Health Science, Korea University,
            Anam-ro 145, Seoul 02841, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: PacBio SMRT Analysis v. v2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 187.01x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019334745.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 05:25:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,312
            CDSs (total)                      :: 2,251
            Genes (coding)                    :: 2,232
            CDSs (with protein)               :: 2,232
            Genes (RNA)                       :: 61
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 19
            CDSs (without protein)            :: 19
            Pseudo Genes (ambiguous residues) :: 0 of 19
            Pseudo Genes (frameshifted)       :: 3 of 19
            Pseudo Genes (incomplete)         :: 17 of 19
            Pseudo Genes (internal stop)      :: 2 of 19
            Pseudo Genes (multiple problems)  :: 3 of 19
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:09:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 568299
            Orig. end                         :: 589433
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP079819.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21134
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21134
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21134
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11134](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11134)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            93..413
                     /locus_tag="LPB401_RS02390"
                     /old_locus_tag="LPB401_02390"
     CDS             93..413
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012584.5"
                     /locus_tag="LPB401_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02390"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_006888857.1"
                     /transl_table=11
                     /translation="MKEPQKVKDFFMPQNSNSPQHPNEHTLHSNQDDLGPTIVCAPFAG
                     YLTLLVGQGEHVDAGQKLAIVEALKVETLVTARTHGRVGRITHTDGSYVTGGQLLLTIV
                     PE"
     gene            535..1971
                     /locus_tag="LPB401_RS02395"
                     /old_locus_tag="LPB401_02395"
     CDS             535..1971
                     /EC_number="1.8.1.15"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888907.1"
                     /locus_tag="LPB401_RS02395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02395"
                     /product="mycothione reductase"
                     /protein_id="WP_006888907.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-39, bitscore:
                     132.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKDLEVIDGVAQYDLVVIGSGSGNSIIGPEWDDKTVAIIDGGI
                     FGGTCLNVGCIPTKMFVYPATVAVKTQEVAELGVEASVQNISWQNMRDRIFPHRIDKIS
                     EAGRQWRANLPNVDFYPEYAHFTGRHTLQTASGRKVHGKQVVIAAGSRATRPDVPGINL
                     PQVLTNDTVMRMEHLPQRMVVLGGGVVAAEFAHVFSALGVEVTQANRSARLLRGVDEEV
                     VNRFAQAASQQWNLLLEHALIEIRQNDDDSVTVVLENDGELVDVVADKVLVATGRRPNS
                     DSLHAEKFFDVDARGLIGVDEYQRVLYNGAPVEGVFALGDISSPYQLKHVANHEARIVQ
                     HNLSHPNELRASDHRFVPAAVFSHPQLAYVGLTEEQARAAGEREGFEVTVKSQEFGDTA
                     YGWAMEDKVGLCKLIARKDTGQLLGAALVGEESSVLIQPLIQAMSFGLGVREMARGQYW
                     IHPALTEVVENALLGLEINA"
     gene            complement(2134..4212)
                     /locus_tag="LPB401_RS02400"
                     /old_locus_tag="LPB401_02400"
     CDS             complement(2134..4212)
                     /NRPS_PKS="Domain: AMP-binding (36-469). E-value: 5.6e-87.
                     Score: 283.9. Matches aSDomain:
                     nrpspksdomains_LPB401_RS02400_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888843.1"
                     /locus_tag="LPB401_RS02400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02400"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_126926544.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-87, bitscore:
                     290.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVFSVPAEVMCDPQLNITSILERRCADTTNPLLYRWQMSPGNWQ
                     PVRAREFRAMVVAVAKGLIASGIVPGDRIGIMSRTRFEWTLIDFAIWYAGAVSVPVYET
                     SAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIEPLHLENTWVINNGALDALITAGL
                     NVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCPLTHGHFLNLSVNTKLAEPEIANP
                     HNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIKNLAADLDSFKPTMLLVVPRVFEK
                     IYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKISGRVPLALAAQYTFYDRLVYAKLR
                     AAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGYGLTETCAPIAAGRISEFQIGAIG
                     PLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDATAFTEDGWFKTGDLARFDERGNLT
                     IVGRKKEIIVTAGGKNVVPSVAEDHIRTSPLVSQAMLVGDQKPFIAALVTLDPDTLPEQ
                     LEHLGLPRAMSIPEAAVHPKVREAVQMFIDEANLLVSRAEAVREFRIMNKDLTEADGYL
                     TPSQKLKRSKILKDFSAYVDDMYSRVSGDMGVRLERLQEIKEQASEKLHEYAEQASERI
                     EELREQASERLQGYQAARAQKTESTEQVEATAVTSDGPKDTAVIEAAEDDTSRSHEQ"
     aSDomain        complement(2806..4104)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LPB401_RS02400_AMP-binding.1"
                     /evalue="5.60E-87"
                     /label="LPB401_RS02400_AMP-binding.1"
                     /locus_tag="LPB401_RS02400"
                     /protein_end="469"
                     /protein_start="36"
                     /score="283.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="WQMSPGNWQPVRAREFRAMVVAVAKGLIASGIVPGDRIGIMSRTR
                     FEWTLIDFAIWYAGAVSVPVYETSAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIE
                     PLHLENTWVINNGALDALITAGLNVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCP
                     LTHGHFLNLSVNTKLAEPEIANPHNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIK
                     NLAADLDSFKPTMLLVVPRVFEKIYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKIS
                     GRVPLALAAQYTFYDRLVYAKLRAAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGY
                     GLTETCAPIAAGRISEFQIGAIGPLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDAT
                     AFTEDGWFKTGDLARFDERGNLTIVGRKKEIIVT"
     CDS_motif       complement(2902..2976)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LPB401_RS02400_0002"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="LPB401_RS02400"
                     /protein_end="437"
                     /protein_start="412"
                     /score="17.8"
                     /tool="antismash"
                     /translation="GELQVRGVGVIDGYYKNPQEDATAF"
     CDS_motif       complement(3607..3666)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LPB401_RS02400_0001"
                     /evalue="2.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="LPB401_RS02400"
                     /protein_end="202"
                     /protein_start="182"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATIVYTSGTTGRPKGCPLTH"
     gene            complement(4232..5071)
                     /locus_tag="LPB401_RS02405"
                     /old_locus_tag="LPB401_02405"
     CDS             complement(4232..5071)
                     /NRPS_PKS="Domain: Abhydrolase_1 (53-154). E-value:
                     1.5e-14. Score: 46.2. Matches aSDomain:
                     nrpspksdomains_LPB401_RS02405_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888837.1"
                     /locus_tag="LPB401_RS02405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02405"
                     /product="carboxylesterase"
                     /protein_id="WP_023134578.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.4e-14, bitscore:
                     50.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.1e-09, bitscore: 35.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIFENSLEPVRRIRRKVHERQQTGGVPAQQPDFNHEPLSSPADP
                     KKYAGDLGILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAVTHYTDW
                     IDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFVDVNPLMRIA
                     HRVAPVLPVMRSIGSDIAVPGVDEGAYARTPTASIRQLHLLGVETRELLPKLHAPVLYL
                     RSVSDHTVTDASHHYFLQHVSASVEFKWLTRSYHVATLDYDAELVKEFTHKFVQSLS"
     aSDomain        complement(4610..4912)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LPB401_RS02405_Abhydrolase_1.1"
                     /evalue="1.50E-14"
                     /label="LPB401_RS02405_Abhydrolase_1.1"
                     /locus_tag="LPB401_RS02405"
                     /protein_end="154"
                     /protein_start="53"
                     /score="46.2"
                     /tool="antismash"
                     /translation="ILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAV
                     THYTDWIDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFV"
     gene            5348..6109
                     /locus_tag="LPB401_RS02410"
                     /old_locus_tag="LPB401_02410"
     CDS             5348..6109
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888851.1"
                     /locus_tag="LPB401_RS02410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02410"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_006888851.1"
                     /transl_table=11
                     /translation="MVTHPATTPVYAVLKAISDPTVRRIWPHEVIGAENMPNGPAIIAS
                     NHLAFCDSVFIPLAVKPTVNFLAKSDYFTTPGFKGRAMAAFFRSVGQLPMDRSGGEKSR
                     ASLEAGLKVLRAGGVLGIYPEGTRSPDGRYYRPKIGVARLALESGAPVVPVGQLGTDLI
                     QPAGTNRPRFRHNGKPITVRTIIGKPLEFAHLQDKANDHATLRAVTDQIAEAIRALSGQ
                     QYVPVPADKVKRLMAAHGWSAQTAVASLLTH"
     gene            6298..7686
                     /locus_tag="LPB401_RS02415"
                     /old_locus_tag="LPB401_02415"
     CDS             6298..7686
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888865.1"
                     /locus_tag="LPB401_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02415"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_023134580.1"
                     /transl_table=11
                     /translation="MSNTIRPQQPSDHGLDIWRTLNADQQPTWADHPDYTPTVAELEKL
                     PPLVFAGEVDSMRHQLAEVAEGRAFLLQGGDCAETFAGATADKISGRVRTILQMAAVLT
                     YGASMPVVKMGRIAGQFSKPRSSDVETRDGVTLPSFRGETVNGHEFTAEARTHDPKRML
                     RGYHTSSATLNLVRAFTKGGFADLRSVHQWNRGFTENPAHARYEETAREIGRALKFMEA
                     CGVDFNALTTTDLYVGHEALVLDFERALTRIDSRTHQPYDTSAHFLWIGERTRGINDAH
                     VDFLSKVRNPIGVKLGPGTTTDDALALIDKLDPEREPGRLTFITRMGAKNIREKLPALV
                     EGVNASGAKVVWVTDPMHGNTISVPSGIKTRRFDDILDEVRGFFEVHESLGSFPGGIHV
                     EMTGDDVTECLGGSDPVDEAALANRYESLCDPRLNHSQSLEIAFLVSEYLKSQYVRQLG
                     NTMR"
     gene            complement(7774..9327)
                     /locus_tag="LPB401_RS02420"
                     /old_locus_tag="LPB401_02420"
     CDS             complement(7774..9327)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398831.1"
                     /locus_tag="LPB401_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02420"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_081697431.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-44, bitscore:
                     149.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNPPPSSTPSSSPASSATRGRDWLNGIIFDEHYLAGPLIAGGGM
                     AEVYYATDTWLNDSPVAIKILKPELAASPENQRKFYSEESSLRQMGGGHVIGVLSSGEQ
                     TVRGQKLRYIVMEYVHGCTLGQLLRERGALSVGEALQILLPVVEGLSEAHARRLVHSDI
                     KPGNILLDVTETVKLADFGLTRRDDQALTGEIMGTPAYAAPELVKGQQTGAPADIFALG
                     VMMYLMFAGHLPFDGIANSSEVHRYNANVEIPPVAEAAPGLDPGLAGLISWCTRQQPED
                     RPENALEVLTDLRDVTAHMSEEELAWRTPLVEEPEVPLWEAVEHIAETTGLAQMVHNSP
                     ISGIGRAEDLLVDTNRRAQAAKPVLPMEEYVPLSIGIGPETRPVNPALARGDIPLSGQR
                     SLDGSSARMHYGALRPELAQRSPNNVFGLPRTPPGPNRSPQRRPASHPQARPGPRPFPR
                     NRRLPAERLGPPPSPFTVVTGVVVLLVALVLAGFVGWLLAQSVLQSTWWANLSQMFGGL
                     "
     gene            9520..9888
                     /locus_tag="LPB401_RS02425"
                     /old_locus_tag="LPB401_02425"
     CDS             9520..9888
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888853.1"
                     /locus_tag="LPB401_RS02425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02425"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_219098583.1"
                     /transl_table=11
                     /translation="MSSEKTVQTFALVGDWVTIPDIAEALDLKVTRVHNLISDGTLVGL
                     REPDTNVRKVPALFLNGDHVLESLKGTLVVLKDAGFSDEEAITWLYTADDSLPGRPIDA
                     LINGQKTEIRRRAQALAW"
     gene            complement(10001..11134)
                     /locus_tag="LPB401_RS02430"
                     /old_locus_tag="LPB401_02430"
     CDS             complement(10001..11134)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888910.1"
                     /locus_tag="LPB401_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02430"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_219098584.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.1e-38, bitscore:
                     129.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQSAFETQIQAEQQAYLQEVEAEMARFFTQQREVLSNISPDAF
                     SLLEAIEALSTGGKRLRALLSYWGWRGAGGVSILEDPKPLSVVRIGAAIELFQSAALIH
                     DDIIDRSDTRRGAPAVHKRFENQHKSSAWRGDTFNYGLTGGIIAGDLCLSWSETMFART
                     GVGSLPDRTARTVFDTMRTEVMAGQYLDVLSEVIDSEDYDATLQRAQNVIRYKSAKYSC
                     EHPLTLGGALALDARQNQNHPILNAYRSFGLPLGEGFQLRDDQLGVFGEPETTGKPAGD
                     DIREGKRTVLVALTEKNADQAGRSLLETCLGNPNLDVHDVQRVRGLMLSCGAVAQLEEL
                     IARKSAAIDTALAVLPVPEQVREALEAIAAKALHRAA"
     misc_feature    11170..11186
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     misc_feature    complement(11175..11195)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    11233..11242
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.04"
                     /tool="antismash"
     misc_feature    11237..11250
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(11250..11268)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.59"
                     /tool="antismash"
     misc_feature    11253..11271
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            11359..12696
                     /gene="dinB"
                     /locus_tag="LPB401_RS02435"
                     /old_locus_tag="LPB401_02435"
     CDS             11359..12696
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="dinB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888896.1"
                     /locus_tag="LPB401_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02435"
                     /product="DNA polymerase IV"
                     /protein_id="WP_219098585.1"
                     /transl_table=11
                     /translation="MSENVKNVFNTSRFQRGNTADDRSEKPRIMMHLDMDAFFVNVELL
                     NKPELHGTPIIVAHEGPRSVVCSASYEARGSGVHSGMPLARAKRLSPEATVLPLRGDYG
                     FYSRAVMRILRDESPLVEQVSVDEAFIDLTGATAIGGSPVAIAQRVRERIADELSLPCS
                     AGISINKFLAKMASTGSKPNGLWVVPPHRVQEFLDPMPVNKLWGVGARSATLLNEYGIY
                     TVAQLREFDTQWLCGRFGNAAGNHLYALARGIDHRPVVTERVEKSMGAEHTFAADTRCA
                     TDIERAVQGIALRLGRRLRAAGKTAGALTIKYRYEGFETHTKSIPLTEPVDSGMQIYRI
                     ACAALRAMGLLVKSRDGQKEQASRALRLIGVRAERLQQCASGVQQTLFALDPQEGDGAE
                     KADWGRVERALDGIHTRFSAEAVRPASLMGYTAGRTHMHRVQHRQG"
     gene            13007..13405
                     /locus_tag="LPB401_RS02440"
                     /old_locus_tag="LPB401_02440"
     CDS             13007..13405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888833.1"
                     /locus_tag="LPB401_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02440"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_006888833.1"
                     /transl_table=11
                     /translation="MALSEREQKVLDQLEELMHAEDPQFASSMSSTGNTAPVFSARHMV
                     LGILCVLAGLGIIIGAVASKIILLGIVGFIVAAGGVYFATTSKKTPIDSFLGGKAKGAS
                     TEKAQQQRKQSKLMERLEERWDEREQGR"
     gene            14031..14459
                     /gene="mraZ"
                     /locus_tag="LPB401_RS02445"
                     /old_locus_tag="LPB401_02445"
     CDS             14031..14459
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888897.1"
                     /locus_tag="LPB401_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02445"
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_006888897.1"
                     /transl_table=11
                     /translation="MFLGTYSPRLDTKGRIILPAKFREELSAGLVLTRGQERCLYVFSA
                     EEFERIHEQMRSAPLSSRQARDYMRVFLSGASDEVPDKQGRVTIPAALREYARLDRELV
                     VIGAGSRAEIWDAQAWDEYLARTEAEFAQLDEEPFPFL"
     gene            14527..15579
                     /gene="rsmH"
                     /locus_tag="LPB401_RS02450"
                     /old_locus_tag="LPB401_02450"
     CDS             14527..15579
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888919.1"
                     /locus_tag="LPB401_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02450"
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_219098586.1"
                     /transl_table=11
                     /translation="MSAKESTHAGAQGAVAPAHTLTLTETPDAGLSKKEAKERHVPVML
                     TRCLDLLAPALEREGAVVIDGTLGMGGHTEAMLERFPELRVIGIDRDPQAHTIAGQRLE
                     RFGERFIPVHAVYDQIEYAMDVAGVNAVDGILFDLGVSSMQLDERSRGFAYSYDAPLDM
                     RMNSEDELTARTVVNEYPLERLRRIIRTWGEEKFAARIAERIVAQRAVQPFETTGELVA
                     AIQKAVPAAAQRKGGHPAKRTFQALRIEVNHELEALERAVPVAIDSLSLGGRFVAMSYH
                     SLEDKIVKRGLSAAATSKAPKGFPVELDEHKPTMKVITRGAEPPTEAEIAENSRAASAK
                     LRAGEKIRVT"
     gene            15580..16680
                     /locus_tag="LPB401_RS02455"
                     /old_locus_tag="LPB401_02455"
     CDS             15580..16680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LPB401_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LPB401_02455"
                     /product="hypothetical protein"
                     /protein_id="WP_219098587.1"
                     /transl_table=11
                     /translation="MSVTTKTTMTGERRNTPKPPGRKTRPEGTAAAPGRAGSSHPGSAR
                     RASTTSTSTRRTAQKEKVGASSRAATAGSTTRTSTPSRARTTETARPQGAGATRTSRGA
                     TLLDAPARFLAYTRGVAGVFEKPSTAQFEANTTSVRPKPARGGTAGRAEVREASGAKKR
                     APLARSLRKPTRRGGIMSLLMWAVFLVIPLFLIFNLLMNILVAQRQYELVDMHAQELAL
                     TQQNEALHQELGYNEAPQDLAIRASLLNMFPSTTPATLDVQNGTIQGTPTPAASPTSAN
                     GTRGNLVPAPATRDNDPSGQKAADAQKQAQEKTAKQNREREEKEKQEKEKASAAASPSP
                     SASPQGSQSPQQAQPSQAAPSASANR"
     gene            16854..18701
                     /locus_tag="LPB401_RS02460"
                     /old_locus_tag="LPB401_02460"
     CDS             16854..18701
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888847.1"
                     /locus_tag="LPB401_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02460"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_094757986.1"
                     /transl_table=11
                     /translation="MAHKKKAVSSQSERKLSRRGFMIGASSTGLLGLLSLRLLYVQGLD
                     PQNLAATSRDSRTRTQKVPAVRGQITDVNGHVLARSVQRYNIIADQTIVAEFKRYDHSQ
                     ERVTVTPTELVYEVTDILRTVDPTITDDFVKSKLEGDSRYSVIKTNVTPEIYNRIDALG
                     APFLFGEVISERLYPDGPVGGSVVGRYRIVDEAVEGKENETVERNLSVGIERTFEKELA
                     GVNGKRVYEIGADGVRIPVTQEQVSESVNGKTVRLTLNRDIQYYAQQVMKARVDELKAE
                     WGCAIVMDVRDGSILALADSTTMDPGAEKVENAQDMVPRAISQIIEPGSTEKILTASAL
                     IEKGITTPTDTYDVPATLTVNGQTFKDAFEHPAQRRTFSGIITDSMNTGTVLVGQKMPK
                     EERYEWLKKYGMGEFTGIDIAGEQQGLVSDWKTWDGRQEFTVFFGQGLAQTPLQTAMVF
                     QAVGNLGVKVKPRIVDAIIDPDGTEHKVPVEGAQRVVSEKTARDCLTLMENVVTKGQAK
                     LAQVNGYRVGGKTGTAEAPSEKGGYEGYTTSFIGVAPIENPRFMVSITLQRPKGEVGTI
                     GGTGQFSQIMERVLHTYNIPHSTTEPHIIPIFADGKNSG"
     gene            18825..20567
                     /locus_tag="LPB401_RS02465"
                     /old_locus_tag="LPB401_02465"
     CDS             18825..20567
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888886.1"
                     /locus_tag="LPB401_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LPB401_02465"
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="WP_219098588.1"
                     /transl_table=11
                     /translation="MNGEQPGEKLSDEAMPGEELFGKDAQNLRPRLTTGYPLDTLVQKL
                     QNLEAQPHLALSGSRNVTGISMDSRSVREGDLYVALPGAKTHGASFAAAAVAAGAAGIL
                     TDAQGQRIIAEAHLDLADTALIIGTDLRRVLGSLAAFIYGSNDYPQLQRFAVTGTNGKT
                     TTTYMLESVFRAALGVKTGLVGTIQILIDGVSIPSAMTTPESVHVHALLSLMGQRGVRC
                     AAMEVSSHAIDYRRVDGVRYAMSGFTNLTQDHLDLHGGMEEYFDSKAQLFTPECTERAV
                     ITADDPWGQRMLVHAQQQLGAQNTIRLLTNHGAGLEAVPADFGANDWAVTEVMAQGLGH
                     TFVLANGAGERVQARTGLPADFNVSNAALAALMAWLSTSEKEREPLAAALASGEALTPV
                     VPGRMQLIGHSPHTIVDFAHNPDGLIRALEAMDRPGEGRVIIVFGATGERDQGKRPIMG
                     EIAARYADIVIVTDDDPHGEDPAPIREAVAAGAQQAIAAGARAHEVHNIAPRARAIAQA
                     IDMATPDDAVLIAGRGHETAQDVAGVDVQLDDRIEVARAMVTRGFEILPDYRRMLEENA
                     EDKK"
ORIGIN
        1 tccattactg gcccgatgag gaagccgtgg acccggcaac ccgtttcacc cgcctgctca
       61 cggggcttgt cgccgccctg tagccgttgg atatgaaaga gccgcagaaa gtaaaggact
      121 tcttcatgcc gcagaacagc aactcgccgc agcacccaaa cgaacatact ctacactcaa
      181 accaggatga tctggggccc actatagtgt gtgcaccgtt cgccgggtac ctgactctgc
      241 tcgtgggtca gggcgagcat gtggacgcgg gacagaagct cgctatcgtc gaagccctta
      301 aagtggaaac tctggtaacg gctcggacgc acggtcgggt tgggcgtatt acccacaccg
      361 atggctcata cgtaactggc gggcagctgc tactgactat agtgccggaa taaaacctaa
      421 gtccccgtgt tatagctacc gttagaatga tacgaagggc acctgaggcc ctagaaactg
      481 gcaaaccaga gaaccggcag gcccgggacc accacatgat aaaggtagga gcgcatgagc
      541 attaaagacc tcgaagtcat tgacggggtg gcacagtacg accttgtagt gatcggctct
      601 gggtcgggca atagcattat tggacccgag tgggatgata agacagtcgc cattattgac
      661 ggcggtatat ttggcggcac ctgcctaaac gtggggtgta tccccacaaa aatgtttgtg
      721 tatccggcca ccgtggcagt taaaacgcaa gaagttgctg agcttggcgt tgaagcatcc
      781 gtgcaaaaca tttcgtggca gaacatgcgc gaccgcattt tcccacaccg aatcgataag
      841 atttctgagg ctggccgcca atggcgtgct aacctgccga acgttgactt ctacccagag
      901 tatgcgcact ttaccggccg gcacaccctg cagactgcat cgggccggaa ggtccacggt
      961 aagcaggtgg ttatcgccgc cggttcacgc gccacgcgcc ctgacgtgcc cggaattaac
     1021 ctgccgcagg tgctcacaaa tgataccgtg atgcgcatgg aacacctacc gcagcgtatg
     1081 gtggtgcttg gcggcggggt agtggccgca gagttcgcac atgttttctc agcgctgggc
     1141 gttgaggtaa cccaggcgaa ccggtcagcc cgcctgctgc gcggcgtgga tgaggaggtt
     1201 gtgaaccgtt tcgcccaagc cgcatctcaa cagtggaatc tgctgctgga gcacgctctc
     1261 atcgagatcc gtcaaaacga tgacgactca gtaaccgtgg ttcttgagaa cgacggcgaa
     1321 ctagttgatg tggttgccga taaggtgctg gtggctacgg gacggcgtcc aaatagtgat
     1381 agcctgcatg ctgagaagtt ctttgacgta gatgcccgcg gccttattgg tgtggacgag
     1441 tatcagcggg tactgtacaa cggcgccccc gttgaaggcg tttttgctct gggggatatc
     1501 tcctccccat atcagcttaa acatgttgct aaccacgagg cgcgcatcgt gcagcataac
     1561 ctgtcccacc cgaacgagct acgcgccagc gaccaccgct ttgtgcccgc ggctgtgttc
     1621 agccacccgc agctggcgta tgtgggcctc accgaggagc aggcgcgtgc cgccggtgaa
     1681 cgtgaaggct ttgaggtgac cgttaaaagc caggagtttg gggataccgc ctatggctgg
     1741 gcgatggagg ataaagtggg gctgtgcaag ctgatcgccc gtaaagacac cggtcagctg
     1801 ctgggggcgg cgctggtggg cgaggagtca tccgtgctca ttcagccgct cattcaagcg
     1861 atgagcttcg ggctgggggt gcgcgagatg gcccgcggcc agtactggat tcaccccgca
     1921 ctgactgaag ttgttgagaa cgctctgctg gggcttgaaa tcaacgcata gctatagctg
     1981 caaaatatgc cgcagggcaa gttttcccgg tttgaggaga ctcggtggga aagcctgccc
     2041 tgcggcatgc atcttctggg aaacatatac ctggcagccg tcagcgcaca ttgcgtacat
     2101 gcggcacccg actgttccgg cccaaggccg aacttattgc tcgtgggagc gagaagtgtc
     2161 atcttctgct gcttcgatca cagcggtatc cttggggccg tcagaggtca cagcagtcgc
     2221 ctcaacctgc tcggtacttt cggttttctg cgctcgcgca gcctgatacc cctgcagcct
     2281 ctcactggcc tgctccctga gctcctcaat gcgttcgctg gcctgctccg cgtattcgtg
     2341 cagtttctcg gacgcctgct cttttatctc ctgcagccgc tctagacgca cacccatatc
     2401 gccggagacc cggctgtaca tatcgtccac atatgcggag aaatctttca gaatctttga
     2461 gcgtttaagc ttctgcgatg gcgtcaggta accgtcggct tccgtcaggt ctttgttcat
     2521 gatgcgaaat tcacgcactg cctctgcccg agacaccagc aggtttgcct cgtcaataaa
     2581 catctgcact gcctcacgca ccttcgggtg caccgctgcc tcggggatgc tcatggcacg
     2641 cggtaatccc aggtgttcca gctgctccgg cagcgtatcc gggtcaagcg tcaccagcgc
     2701 ggcaataaac ggtttctggt ctcccaccag cattgcttga gataccaagg gggaggtgcg
     2761 gatgtgatct tccgccacgg acggtaccac attcttaccg cccgcagtca caataatttc
     2821 tttcttgcgg cccacaattg tcaggttgcc gcgttcatca aagcgggcca ggtccccggt
     2881 tttaaaccag ccgtcttcag taaatgcggt ggcgtcttcc tgagggttct tatagtatcc
     2941 atcgatcaca cccacgccgc gcacctgcag ttcgccgtct tcggcaatac gcccctgcgc
     3001 tcccggtaag agcgggccga tggccccgat ctggaactcg ctaatacgcc ccgctgcaat
     3061 cggcgcgcaa gtctccgtga gaccgtaccc ttcaaccacc cggataccta cagcgtggaa
     3121 gaagtggcct agagtatcgg atagcgggcc accgcccgag acggcgtact ttagctgccc
     3181 gcccatcgcc gctcgcagct tcgcgtacac gagcctatcg tagaacgtgt actgggccgc
     3241 caacgcgagg ggaacccgcc cggaaatttt agcgcgcgac cactcaacag caaccttcac
     3301 tgagcggtca aatagggctt tgttgagtgt tccgccttta gctgctttag ccttcgcccc
     3361 ctcatagatt ttctcaaaca cgcggggcac taccagcagc atagtcggtt taaaactgtc
     3421 cagatcggca gcgaggtttt taatattggg ggagtgccca atctgtacgc ccgcgtccat
     3481 cgccaatatc tgaatcagcc tggcgagcac atgcgccaac ggcagaaaaa taatagagga
     3541 attatgggga ttcgcaatct ctggttccgc cagtttggtg tttacgctca ggttcaggaa
     3601 atgcccgtgt gttagcgggc accccttcgg cctgccggtg gtacctgagg tgtacacaat
     3661 agttgccagg gagctgcagg tggcggtgtc acgtgccgta tacactgctt cttccggcac
     3721 gttgagccca gccgtaatga gtgcatccag ggccccgtta ttaataaccc aggtgttttc
     3781 aaggtgcaac ggctcaatgc tgtttgcctg ttcgataaca ccagccagct tatcgtcctc
     3841 aacgaaaact gctttcgctt cggagtgaga aagagcccac gccgcctggg cgggcgcgct
     3901 cgtctcatat acgggaacag agacggctcc cgcataccag atagcgaagt caatgagagt
     3961 ccattcgaac cgggtgcggc tcataatgcc gatacgatct ccgggaacaa taccggaggc
     4021 gatcagccct ttagccaccg ctaccaccat ggcccgaaat tcgcgggccc gcaccggctg
     4081 ccaattcccc ggtgacatct gccagcgata caacaacggg ttggtagtgt cagcgcaacg
     4141 gcgttctaag atgctggtga tattcagctg cgggtcgcac attacctctg ctggaacaga
     4201 gaaaaccttc atgagttacg ccttccacgc cctagcttaa ggactgtaca aatttgtgtg
     4261 tgaattcttt aacaagctcg gcatcgtaat caagggtcgc cacatggtag ctacgggtga
     4321 gccatttaaa ttctaccgat gccgagacat gttgcagaaa atagtggtgt gacgcgtcag
     4381 taacggtgtg gtctgatacg gagcgcaagt acagtacagg tgcatgcagt ttcggcagta
     4441 gctcgcgggt ttctaccccc agcaggtgta gctgccggat agacgcggtg ggagtgcgtg
     4501 catatgcccc ttcatctaca cccggcacgg caatatcgga ccctattgag cgcattaccg
     4561 gcagcactgg tgccacccgg tgggcaatgc gcatgagcgg gttgacatca acaaagaacg
     4621 ggttaataag cactgtgcca gcaaccgggc ggcgtgccgc aaggtgcgcg gcaaggcatc
     4681 cacccataga cataccgata acaattactc gatatcccgc accagtgagc cgctcgtacg
     4741 cctgctcaac actatctatc caatcggtgt agtgggtgac tgccatatca cgccagtgag
     4801 ttccgtggcc gggtaagcgg ggtaactcca ccgggtaccc tttctctgct aaatacgctg
     4861 ctaacgggtg caagctgtgc ggagagcctg tgaacccgtg cacgatgagg atacctaagt
     4921 cacccgcata ctttttgggg tctgcggggg acgacagcgg ttcgtggtta aagtccggct
     4981 gctgcgcagg caccccacct gtctgttgcc tctcgtgtac tttgcggcgt atccgacgca
     5041 ctggctctaa cgagttctca aaaatattca tacatccccc aggaagctgt gtaaccccac
     5101 acttaatatc tagcactatt attgctttca aggtgagata aaaactcacg ctattgagct
     5161 gtgagcgtga tttcgtgcga ttcacaggta actggcaggt gaaaatgggc tgtataacac
     5221 ccaatggacc ccctggtacc cggctacaat ctactaggaa ggcactcgcc cctccgatga
     5281 cgcacaccgg tgtgaattaa tcgaaccgtg ccgcgttcaa taaccggaaa cactccagga
     5341 gaaaactgtg gtcacacacc ccgccacaac acccgtatat gcggtactta aagcaataag
     5401 cgaccccact gtccggcgga tctggccgca tgaagtcata ggtgctgaaa acatgcccaa
     5461 tggtccagcc attattgcca gtaaccactt agccttctgc gattcggtgt ttattccgct
     5521 tgcggttaaa cccaccgtaa atttcttagc gaaaagcgac tatttcacta cccccggctt
     5581 taaagggcgt gcaatggcag ctttcttccg cagcgtgggc cagcttccta tggatcgttc
     5641 gggtggggag aaaagcaggg cttctttaga agcgggtcta aaggtacttc gtgcaggggg
     5701 agtgctcggc atctaccctg aaggaacccg cagtcctgac ggacgctact accgccctaa
     5761 aattggggtg gcgcgtcttg cgctggaatc tggtgcaccc gtggtacctg tgggtcagct
     5821 gggcaccgac ctaatacagc cagccgggac gaacaggcca cgttttcggc ataatgggaa
     5881 acccattacg gtacgcacta ttattggtaa accgttggag ttcgcacatt tgcaggataa
     5941 agctaatgac cacgccacgc tcagggctgt gaccgatcag attgctgagg ctattcgcgc
     6001 cctctcgggg cagcagtacg tgcctgtgcc cgccgacaaa gttaaacggc tcatggcggc
     6061 tcatgggtgg agcgcccaaa ccgcagtagc tagtcttctc acacactaac agccacattt
     6121 tggttgtacg ggccgctttg tggcgtgtga tttcacgcag cgaggtaaaa acatgaccgc
     6181 tccgtaccgt cttgcccata gcgggagtac aataacgtag tactgcctca tggttttaac
     6241 tatggggtac cgcaaccgca gacaacccaa cctgagtgat agagcgagac aacatacatg
     6301 agcaacacga ttcgcccgca acagcccagc gaccatgggc tggatatttg gcgcaccctt
     6361 aacgctgacc agcagcctac ctgggcggat catcccgact acacgcccac agtggcagaa
     6421 ctcgaaaagc tgcccccgct ggtctttgcg ggggaagtag actcaatgcg ccaccaactt
     6481 gctgaagtcg ctgaaggtcg cgcttttctg cttcagggcg gagactgcgc cgaaacgttc
     6541 gcgggagcca ccgccgataa aatttcaggc cgtgttcgca ccatcctaca gatggcagcg
     6601 gtactgacct acggggcctc tatgcctgtg gttaagatgg gccgcattgc cgggcagttc
     6661 tctaaacccc gctcctcgga tgtggaaacc cgtgatggtg ttaccctgcc ttcgttccgt
     6721 ggagaaaccg ttaacggtca tgagttcaca gcagaggcgc gcactcacga ccccaagcgg
     6781 atgctgcgcg ggtaccacac ctcctcggca accctgaacc tggtgcgggc tttcacgaag
     6841 ggcggttttg ccgatctgcg ttccgtacac cagtggaacc gcgggtttac cgaaaaccct
     6901 gcgcatgccc gctatgaaga aactgcgcgt gaaataggcc gtgccctcaa atttatggaa
     6961 gcctgcggag tggactttaa cgcattgacc accaccgacc tgtacgtggg ccacgaggca
     7021 ctggtgcttg attttgaacg tgccctcaca cgcatcgatt cgcgtaccca ccaaccgtat
     7081 gacacgtccg cacacttttt gtggattggc gaacgcaccc gaggaattaa cgacgcccac
     7141 gtagacttcc tctctaaggt gcgtaacccc atcggtgtta agctgggccc cggcaccacc
     7201 accgatgacg cactagctct tatcgacaag ctcgaccctg aacgggagcc cggtcgtctt
     7261 acttttatca cccgcatggg ggcaaagaac attcgtgaaa aacttcccgc tctcgttgag
     7321 ggggttaatg catccggggc gaaggtcgtg tgggttaccg accccatgca cggcaacact
     7381 atatccgttc catcagggat taaaacccgc cggtttgatg acatcctgga tgaggtgcgc
     7441 ggcttctttg aggtgcatga gtccctgggt tctttccccg gtggcatcca cgttgaaatg
     7501 actggggatg acgtcaccga gtgtttgggc ggctcagacc ccgtggatga ggcagcactg
     7561 gctaaccgct acgaatcgct gtgtgatccg cgactgaacc attcacagtc tctggagatc
     7621 gcattcttgg tatctgagta cctgaagagc cagtacgtgc gccaattggg taatactatg
     7681 cgttaagcac acccacataa acgtatgatg aggccgatga gccgtcctaa agagggcagc
     7741 gcatcggcct taaaacatat gaggtgtggg ggattagagc ccaccaaaca tttgtgacag
     7801 gttagcccac cacgtgctct gtaataccga ctgggccagc agccacccca cgaaccctgc
     7861 caaaactaga gccaccaaga gtacgaccac tcccgtcact actgtaaacg gcgatggtgg
     7921 cggacctagc cgttcagcag ggagcctcct gttacggggg aaaggacgcg ggccgggccg
     7981 cgcttgcgga tgcgatgctg gcctgcgctg tggggaacgg ttagggcccg gtggggtgcg
     8041 tggaagtcca aagacattat tcggggaacg ctgagcaagc tctgggcgca gcgcgccata
     8101 gtgcatccgc gccgaggaac cgtccaagga ccgctggccg ctcaggggga tatcgccacg
     8161 cgctaaggca gggtttaccg gccgggtttc agggccgata ccgatcgaga gcggaacgta
     8221 ttcttccatg ggcagcacag gttttgcggc ctgggcccgc cggttagtgt ccaccagcag
     8281 atcctcagca cggccaatac cactgatggg gctgttgtgc accatctggg ccaaccccgt
     8341 agtctcagcg atgtgttcca cagcctccca tagcggaact tcaggttcct ccacgagggg
     8401 agtgcgccag gcaagctctt cctcgctcat gtgggcagtc acatcccgca gatcggttag
     8461 aacttcaagc gcgttctctg gacggtcttc aggctgctga cgggtacacc agctaatgag
     8521 ccccgcaagc cctggatcta ggccgggagc agcctcagcg acgggcggga tttcgacgtt
     8581 tgcattgtaa cggtgaacct cgctgctgtt ggcgatgcca tcaaacggca gatgcccggc
     8641 gaacatgagg tacatcatca cgcccaaggc aaaaatatcg gcgggtgcac ccgtctgctg
     8701 gcctttgacc agttccggtg cagcgtatgc gggggtgccc ataatctcac cggtgagcgc
     8761 ctggtcgtcg cggcgcgtca acccgaagtc tgccagtttt accgtttcgg tcacatccaa
     8821 caaaatattg ccgggtttaa tatcgctgtg taccagccgt cgtgcatgag cctcagacag
     8881 tccctccact accggcagta gaatctgcag ggcttcccct acagataggg caccacgctc
     8941 ccgcagcagc tggcctagag tacacccgtg cacgtactcc atgacaatgt accgtagctt
     9001 ctgcccgcgt accgtctgtt cacctgagga aagcacgccg atcacatgtc cgccgcccat
     9061 ctgccgtagc gatgactctt cactgtaaaa cttgcgctga ttctcgggtg aagcggcaag
     9121 ttcaggtttc agaattttaa tagccaccgg ggaatcattg agccacgtat cggtcgcgta
     9181 gtacacttcg gccataccgc cgccagcaat gagcgggcca gccaagtagt gttcatcgaa
     9241 gatgatgccg tttaaccagt cacgcccccg cgtcgcagaa ctcgcggggg aagaagacgg
     9301 tgttgaagat gggggaggat tcatcatcta cgattctagg ggatatgtgg tgtccatgcc
     9361 gcatggacaa ctcccactga gcaaagatac agcggattca taggtaaaga gggtaaaacc
     9421 ggccaagtaa tagagcccga accacacacc ataacagaac cggtaataat ggcggcgcat
     9481 aagtaggcaa aattgggtag attctggcac tcttaaaagg tgagtagcga aaaaactgta
     9541 cagacctttg cccttgtagg cgactgggtc actattcccg atattgccga ggcacttgat
     9601 ttgaaagtta ctcgagtgca caaccttatc tcagatggca ctcttgtagg cctgcgcgag
     9661 ccagacacga atgtgcgtaa agtacccgcg ctttttctca acggcgatca tgtgctcgaa
     9721 tctctcaaag gcaccttagt agtgctcaaa gacgctggtt ttagcgatga ggaagccatc
     9781 acctggctct acactgcgga tgattctctg ccgggacgtc ccattgatgc gctcattaac
     9841 gggcagaaga cggaaatccg ccgccgcgca caggccctag cctggtaaaa cccaagcccg
     9901 ataaaaccgc gcgccgttga gtatttgggc gctttcctca aactagtgac ggtggagggg
     9961 gccacccgca tgatggggca gtcccctcca ccttttacag ttacgcggct cgatgcagcg
    10021 cttttgctgc gatagcttct aaggcttccc gtacctgctc cggtaccggt aaaacagcca
    10081 gcgccgtatc aatggcagca gacttgcggg caatgagctc ctcaagctgc gccactgcac
    10141 cacaagaaag catgagacca cgcacccgct gaacatcgtg aacatctagg ttcgggttcc
    10201 ccaagcatgt ctcaagcagg gaccgtcccg cctgatccgc attcttttcc gtaagtgcca
    10261 ccagtacggt gcgttttcct tcccgaatat catccccggc aggttttcca gtggtttcag
    10321 gctcaccgaa cacccccagc tgatcatcac gcagctgaaa gccttcaccc aagggcaagc
    10381 cgaagctgcg gtacgcatta agaatggggt ggttctggtt ctgccgtgca tcaagggcta
    10441 gagcgccgcc aagagtcagc gggtgctcgc atgaatattt agctgactta taacggatca
    10501 cgttctgggc acgctgtagt gtcgcatcat aatcttcgga atcgatgact tccgagagca
    10561 catccaggta ttgcccggcc atgacttcgg tgcgcatcgt atcgaaaaca gttcgtgcgg
    10621 tgcggtctgg tagggagccc acccccgtgc gcgcaaacat tgtctccgac cacgataggc
    10681 atagatctcc ggcgataata ccccccgtaa gaccatagtt aaaagtatcg ccgcgccagg
    10741 cactactttt atgttggttc tcaaaacgtt tgtgcacggc gggtgctcca cgccgagtat
    10801 cggaacggtc aataatatcg tcgtggatga gcgccgcgga ttgaaacagt tcaatggccg
    10861 cccctatacg caccaccgac aggggctttg ggtcctcaag aatactcacc ccacctgcgc
    10921 cgcgccatcc ccagtagctc agtagcgcac gtagcctttt accacctgtg gagagcgctt
    10981 caatggcttc tagcaggctg aatgcatctg gtgaaatatt ggagagcacc tcgcgctgct
    11041 gggtaaaaaa acgcgccatt tcggcctcaa cctcttgcag atatgcctgc tgttcggcct
    11101 gaatttgcgt ttcaaacgcg ctctgcgtag ccattgttgc tcccgtcgat atatatctgg
    11161 cggtggtcga tacccatcta gcttatgcta tctcccataa tttccggtat tttcgcgtgg
    11221 ggctagccaa ctcgattttt tatagaacaa gaatactata tagaatatat atgctattat
    11281 ggggtggtgg gaggctgaag atacatcaaa gctgaggcac aatagttatc cagggtctcc
    11341 atctataaag ggggtggaat gtctgagaac gtaaaaaacg tctttaatac atctcgcttc
    11401 cagcggggga ataccgctga tgaccgaagc gagaagcccc gcatcatgat gcatcttgat
    11461 atggacgcat tttttgtcaa cgtagagctg ctgaataaac cagaattaca cggaactcct
    11521 attattgtgg cgcatgaggg cccgcgctca gtggtatgtt ctgcttccta tgaggctcga
    11581 ggctcgggtg ttcattcggg tatgccgctg gcacgggcta aacgcttgag cccggaggca
    11641 actgttctgc ctctgcgggg tgattacggc ttttactctc gtgcggtcat gcgaatactg
    11701 cgggatgaaa gcccgcttgt ggaacaagta agtgttgatg aggcattcat tgatctcacc
    11761 ggtgccactg ccatcggcgg atccccggtt gcgatagcac agcgggtgcg agaacgtatt
    11821 gcggacgagc tgtctctacc ctgctcggcg gggatatcta ttaataagtt tcttgccaaa
    11881 atggcctcaa ctggcagtaa acccaatggg ctgtgggtgg tgccacccca cagggtgcag
    11941 gagttcctgg atcctatgcc ggttaataaa ctgtggggtg tgggggcgcg aagcgccact
    12001 ttgctgaacg aatacggaat ctacacggtg gcacagctgc gtgagtttga cacccagtgg
    12061 ctgtgcgggc gttttggtaa tgcggcaggg aaccatctct atgctcttgc tcgtggtatt
    12121 gatcatcgtc cggtggtcac tgagcgtgtt gagaaaagta tgggagctga gcataccttt
    12181 gctgccgata ctcgctgcgc cacagatatt gagcgggcgg tgcagggcat tgctttacgg
    12241 ttggggcggc ggctgcgcgc agcagggaaa accgctggtg cgctgaccat taaatatcgt
    12301 tatgaaggtt ttgagacaca cactaaatct atacccctaa ctgagcctgt agattctggg
    12361 atgcagatat atcgtattgc ttgcgccgcc ctgagggcga tggggctttt agtcaaaagc
    12421 cgcgatggtc aaaaggaaca agcgtcacgg gctttacggt tgataggggt acgcgccgag
    12481 cggctgcaac aatgcgcctc tggtgtgcag cagacgcttt ttgccttgga cccacaggaa
    12541 ggggacggtg cagagaaagc tgactggggt cgtgtggagc gtgcccttga tggcatccat
    12601 acgcgattta gtgcagaggc ggtgcgcccg gcctctctga tggggtacac ggcggggcga
    12661 acacatatgc acagggtgca gcatcgtcag gggtaaggca ggatgagagg catagaagtg
    12721 cgagctttta aagaatatac ggcttagaaa tcccctgagt gttaagcgtt gaggcaggtt
    12781 catgggccgc tgggtactct gatgcatccg cgacaacgca aggatgtggt gagtgcggct
    12841 tttattctca gtacatacac agagatttag ctcaagaaag agtacctatt gggggcctaa
    12901 aaggggtact atgatgaacg tacgctaggc tacatgtgat ggtcttgccc cggggtggat
    12961 atgtgccgac ggcagggctt ttgggcacgg ttttaaggag aatgctatgg cactttcgga
    13021 gcgcgaacag aaagtccttg atcagcttga ggagttaatg cacgccgaag acccgcagtt
    13081 tgcaagttcg atgtcttcga cgggtaatac cgcgcccgta tttagcgccc gccacatggt
    13141 gctgggtatc ctgtgcgtgc ttgctgggct gggcattatt attggggcgg ttgcctcaaa
    13201 gattattctg cttggtattg tcggctttat agttgccgcc gggggcgtgt attttgcgac
    13261 caccagtaag aaaaccccta ttgattcgtt cttaggtggt aaggctaaag gtgcctccac
    13321 tgagaaggcg cagcaacagc gcaaacaatc gaagctcatg gagcgcctgg aagagcgctg
    13381 ggatgagcgc gaacaggggc gttagtatat ttttcttctt gtgatacgtc agtgctggcg
    13441 tgaggtacca ccgtggtaat aggctggtac gtttaaaccg tgttctacct cagacttggt
    13501 ggtggggcgg ggcttccata agggaggccc cgccccactg tccgttaaag gtcgctgtac
    13561 ttgcagctac tgtacacgcc acaccggggt ggtggtacta agagccggta tttatcccaa
    13621 gctagcgtta gcttctgatt atgggtgttt tccccaccgt aagcggtact cacgctgaaa
    13681 ctgaggatgt ttcctccact tttccctcca caatcctcca ccgccccaca ataacccgtg
    13741 tagcggcggg attgtgtctg ctgccgccaa taactctaaa actgcctgcg tggaacgggc
    13801 aataatgtgg tttttcaaaa tatgttggct attcgtgtgt cgaatcagcg ggtggcgaac
    13861 tcctcaataa cggtcctatc tggggtgaag ctgcgggatt caagggcttg acgtgcaggt
    13921 ttattaaaat ttgcgggaaa atttgggtgc ttaaaaaggg ttaagtggtg gaaagtgggg
    13981 taaagtggag ggtagcagat tgttcaagtg cgctgtgagg gggtgggtac gtgtttttag
    14041 ggacgtattc gcctcggtta gacaccaaag ggcgcatcat tcttcccgcg aaatttcgtg
    14101 aggaactttc tgctggtcta gtgctcaccc gcggacagga acgttgcttg tacgtgttct
    14161 ctgcggaaga gtttgagcgt attcacgagc agatgcgttc agcgccactg tcttcacggc
    14221 aggctcggga ctacatgcgt gtgttcctgt cgggcgcatc tgatgaggtg cccgataagc
    14281 aggggcgggt caccatcccg gcggcgttgc gtgagtacgc tcggttagac cgcgagcttg
    14341 tcgtcatcgg cgcgggttcc cgagccgaaa tctgggacgc tcaggcttgg gacgagtacc
    14401 ttgctcgtac cgaagctgaa tttgcacaac tggacgagga gcctttcccc ttcctgtaaa
    14461 ccaccccatc tgttagcgca ttcgctgcgg gagcagatcc tagtacgtga ccctcaagga
    14521 gcgaatatga gcgctaagga aagcacccac gccggtgctc agggagcggt agctcccgca
    14581 cacaccctta cgcttactga aactcccgat gcggggcttt cgaagaaaga agcgaaagaa
    14641 cgccacgtac cggtcatgct taccaggtgc cttgacctgc tagccccggc cctcgaacgt
    14701 gaaggggcag tggtcattga tggaacgtta ggaatgggcg ggcacaccga ggcaatgctt
    14761 gaacgtttcc ccgaactgcg ggttatcggt atcgaccgag acccgcaggc acacactatt
    14821 gcggggcagc ggctggagcg gttcggcgag cggttcatcc ccgtgcacgc tgtgtacgac
    14881 cagattgagt acgccatgga tgtcgccggg gtgaacgccg tcgatggcat cctattcgac
    14941 ttgggtgtct cctccatgca gctggatgag cgttcacgcg ggtttgctta ttcttacgac
    15001 gctccgctcg atatgcggat gaatagtgaa gatgagctga cagcacgcac cgtggtgaac
    15061 gagtatccgc tggagcggct gcggagaatt atccgcacgt ggggcgaaga gaagttcgcc
    15121 gcgcggattg ccgaacggat cgttgctcag cgggccgttc agccgtttga gaccaccggt
    15181 gagctggtag ccgctatcca aaaagcggtg ccagcagcgg cacaacgcaa aggcgggcac
    15241 cctgcgaaac gcactttcca ggcactacgc attgaggtga accacgaact ggaggcactg
    15301 gaacgcgctg tgccggtcgc aatcgactcg ctctccctgg gcgggcggtt cgtggccatg
    15361 agctaccaca gtttagaaga caagatcgtc aagcggggcc tgagtgctgc cgccacctct
    15421 aaggcgccca aagggttccc cgtggagctt gacgaacata agccaacgat gaaggttatc
    15481 acgcgtggcg cagagccacc gactgaggct gaaatcgcag agaattcacg cgccgcaagc
    15541 gcaaaattgc gggctggcga gaagattagg gttacataaa tgagcgtaac aacgaagacc
    15601 accatgacgg gggagcgcag gaacacgccc aaacccccgg gtcgtaaaac acgcccggaa
    15661 gggacagctg ctgcgccggg ccgagcaggc tcctcacacc ccgggtcggc tcgtcgtgcc
    15721 tccacaactt cgacaagcac ccgccgcacc gcgcagaagg aaaaagttgg tgcttcatct
    15781 cgggctgcta ccgctggcag caccacccga accagcaccc ccagccgggc tcgaacaacc
    15841 gaaacagccc ggcctcaggg cgctggtgcc acgcgcacct cacggggggc gaccctgcta
    15901 gacgctcctg cccgtttctt ggcgtacacg cgcggggtag cgggagtatt tgagaagccc
    15961 tcaaccgcgc agttcgaagc gaataccacc tcggtgcggc ctaaacctgc tcggggcggt
    16021 acagctgggc gcgctgaagt gcgcgaagcc tccggtgcaa aaaaacgtgc gccgctggcc
    16081 cgttctttac gtaaacccac ccgccgggga ggcatcatga gccttctgat gtgggcggtg
    16141 tttttggtga tcccgctatt tctcatcttt aacctgctga tgaatatcct agtggctcag
    16201 cgtcagtacg aactggtaga catgcacgcc caggagctgg ctctcaccca gcagaacgag
    16261 gctctgcatc aggagctggg gtacaacgaa gctccgcagg atctagcgat ccgtgcttct
    16321 ctgctgaata tgttccccag caccaccccg gcaactttgg acgtgcagaa cggtacgatt
    16381 cagggcaccc caaccccagc tgcttcgccc acctcagcta atgggacccg cgggaatctg
    16441 gtgccagcac ccgcgacccg cgataatgac ccctccgggc agaaggctgc ggatgcccag
    16501 aagcaggcgc aggagaaaac cgcgaagcag aaccgtgagc gggaagagaa agagaagcag
    16561 gaaaaggaga aggcaagtgc cgccgcctcg ccttcaccct ctgcatctcc gcagggttca
    16621 cagagcccgc agcaggctca gccgtcacag gctgcaccta gcgcctccgc gaatcgctaa
    16681 tacagttcac accccgggta ggggtggtgg cgccgattgg tgtcacctaa tctactcggg
    16741 gtagtgttct gttcggggca agttataagc tgccccggca ggtgccagaa gagcccggcg
    16801 atataggaac aacaatccag gaaatagcgc aggaatgtac cggaaggaac actgtggccc
    16861 acaagaaaaa agcggtatcc tcacagagcg agcgtaaact cagccgacgt ggattcatga
    16921 taggcgccag cagcacgggg ctactgggcc tgctgagttt acgcctactg tacgttcagg
    16981 ggcttgaccc gcaaaacctg gctgcaacct cccgggattc tcgaacccga acccagaaag
    17041 ttcccgcagt ccgtgggcag attaccgatg tgaacgggca cgtactggcc cgtagcgtgc
    17101 aaaggtacaa tattatcgcg gaccagacga tcgtggcgga atttaaacgc tacgaccact
    17161 cccaagagcg tgtgacagtc acccccaccg agctggtgta cgaggtcact gatattttgc
    17221 gcactgtgga cccgaccatc accgatgact tcgtgaagtc aaaacttgaa ggagactccc
    17281 ggtattcggt cattaaaacc aatgtaaccc ccgaaattta taatcgtatc gacgcattag
    17341 gggcgccgtt cctcttcggg gaagtaatca gcgaacgcct gtacccggac gggccggtgg
    17401 gtggttctgt ggtaggccgc taccgtatcg ttgatgaagc agttgagggt aaagaaaacg
    17461 aaaccgttga gcgcaacctc tcggtaggga ttgagcgcac cttcgagaag gaactcgctg
    17521 gggtgaacgg taaacgcgtg tacgagatcg gggccgacgg tgtgcgtatt cctgtgaccc
    17581 aggagcaggt gagtgaatca gtgaacggta aaaccgtgcg tctgaccctc aaccgggata
    17641 ttcagtacta cgcccagcag gttatgaaag cccgtgtaga cgagctcaaa gcggaatggg
    17701 gatgcgccat tgtgatggat gtgcgcgacg gttcaatcct ggcacttgct gattcaacaa
    17761 ccatggaccc gggcgccgag aaagttgaga acgcacaaga tatggtgcca cgtgccattt
    17821 ctcagatcat tgagcctgga tcgacggaga aaatcctcac cgcatcagcg ctcattgaga
    17881 aaggcattac cacccccacc gatacatatg atgtgcccgc caccctcacc gttaacgggc
    17941 aaaccttcaa agatgctttt gagcaccccg cgcaacgccg cacgttctca ggtattatta
    18001 ccgattcgat gaacaccgga actgtgctgg ttggccagaa gatgcccaaa gaagagcgct
    18061 atgagtggct gaaaaaatac ggtatgggcg agttcacagg cattgatatt gccggagaac
    18121 agcagggcct agtctccgat tggaaaacct gggacggacg ccaggaattc acggtgtttt
    18181 tcggccaggg ccttgcacag accccgcttc agaccgctat ggtttttcaa gccgtaggta
    18241 acctgggggt taaagtgaaa ccacggattg tggacgcgat tatcgacccc gacggcaccg
    18301 agcataaggt tcccgtagag ggcgcccagc gtgtggtgag tgaaaaaacc gcccgagact
    18361 gcctgaccct catggagaat gtggtgacta aagggcaagc gaaacttgcc caggtcaacg
    18421 ggtaccgtgt cgggggtaaa accggtaccg cagaggcgcc cagcgaaaaa ggcggctatg
    18481 agggatacac cacatctttc attggtgtag cacccattga gaacccccgg tttatggtga
    18541 gtatcaccct gcagcgcccc aaaggtgagg tgggaactat cggcggcacc gggcaattct
    18601 cccaaatcat ggagcgagtt ctgcatacct acaatattcc gcactccacc accgagccac
    18661 atattatccc catttttgcg gatggtaaga acagcggcta gtctcgtgag ggtgccgagc
    18721 acccgttggc tcattacaat gagaaggtac caatcgcccc agcccagctg tggcacatca
    18781 caagacgata aatagggcgc cccatgcgcg aaggaagaag gacaatgaac ggcgaacagc
    18841 ccggtgagaa actctcagac gaagctatgc ccggtgaaga gctgttcggc aaagatgccc
    18901 agaacttacg gccccgccta accacaggct acccgctaga tacgctcgtt cagaagctgc
    18961 aaaaccttga ggcacagccg cacctagccc tatccggctc ccgaaacgtg accggtatca
    19021 gtatggactc acgctccgta cgtgagggtg atctatatgt agcgctgcca ggtgctaaaa
    19081 cacacggagc tagtttcgct gcagctgctg tagccgcagg cgcagcgggt attcttactg
    19141 acgctcaggg gcagcgcatt attgctgagg cgcaccttga tttagcagat actgcgctta
    19201 taattggcac agatttacgc cgggtgctgg gttctttggc ggctttcatc tacggttcaa
    19261 acgactaccc gcaactgcag cggttcgcgg tgaccggaac aaacgggaaa actaccacca
    19321 cctatatgct tgaatccgtt ttccgtgccg ctctgggcgt caaaactggg ttggtcggta
    19381 ccatccaaat ccttattgac ggtgtgtcga ttccctcagc gatgaccacc cccgaatctg
    19441 tgcatgtgca cgccctgctg tctctcatgg gccagcgtgg agtacgttgt gcagctatgg
    19501 aagtttcttc ccacgccatt gattatcgcc gcgttgacgg ggtgcgttat gcaatgagtg
    19561 gtttcacaaa cctcacccaa gaccacctag acctacacgg tgggatggaa gaatactttg
    19621 actccaaagc acagctgttc acccctgaat gtactgaacg ggccgtgatc accgcagacg
    19681 atccatgggg gcagcggatg cttgttcacg cacaacagca gctgggtgcg caaaacacaa
    19741 ttcggttgct gaccaatcac ggtgccgggt tagaagcggt accggcagat tttggtgcca
    19801 acgattgggc tgtcactgag gtgatggctc aagggttagg acataccttc gtacttgcta
    19861 acggggctgg ggagcgtgtt caggctcgta ccggacttcc cgcagatttt aacgtttcca
    19921 atgcggccct ggcggcactt atggcctggc tcagcacaag cgaaaaagag agagagccgt
    19981 tggcggctgc gctcgccagt ggggaggcac tcaccccggt agttcctggt cgaatgcagc
    20041 ttattgggca cagcccccac actattgttg attttgcgca taatcctgac gggctaatcc
    20101 gtgcgttaga ggcgatggac cgccccggtg agggccgagt cattatcgtg ttcggtgcta
    20161 ccggtgaacg tgatcaaggc aagcgcccca tcatgggtga gatcgctgcc cgctacgcag
    20221 atattgttat tgtgaccgat gacgatccgc atggggaaga cccggccccc attcgcgagg
    20281 ctgttgctgc cggtgcgcag caagctatcg ccgctggggc gcgggctcat gaagtacata
    20341 atattgcccc gcgtgctagg gctattgcgc aggccatcga tatggccacc cctgacgatg
    20401 ccgtgctcat tgcgggccgc ggccatgaaa cagcccaaga cgtagctggg gtagacgtgc
    20461 agctggatga ccgtattgaa gtggcccgcg ccatggttac tcgcggattt gagattctgc
    20521 cagattatcg gcgtatgctg gaagaaaacg ctgaggataa gaaataatga ttaaactaag
    20581 tgccgccgag attatccagg cgaccggagg tgccgcgctc gggcttcaag accccgagac
    20641 ggtcttctgt accttcgcca ctactgattc acgggaagta gtccccggta ccctttttat
    20701 tgcgaaaccg ggagaaagta ccgacgggca ccgttttgtt cccgcagctt ttaactctgg
    20761 tgcttcctta gcccttgttg aacggcccgt taccgctgag ccttcaggtg agctgtatcc
    20821 tgccgtgcag gtggatgatg cggtactggc gatggggcgc ttggcggcat acgctatcga
    20881 gaagatgcgt agtcttggtc ccgtggaagt cattgggatt actggttccg cagggaaaac
    20941 caccaccaaa gatttgctgg cagctatttt tggtgccgag ggtgctacgg tggctcccgt
    21001 gggctcctat aacggtgagg ttggggtgcc gctgacggta ttccgtgcgg atgaaaccac
    21061 ccggtacttg gttattgaaa tgggtgccga ccatgtaggc aatattgagt acctggcgaa
    21121 tattgtacag ccgg
//
