LOCUS       NZ_JAHPZL010000025     11640 bp    DNA     linear   CON 18-AUG-2024
DEFINITION  Austwickia sp. TVS 96-490-7B contig_25, whole genome shotgun
            sequence.
ACCESSION   NZ_JAHPZL010000025
VERSION     NZ_JAHPZL010000025.1
KEYWORDS    WGS; RefSeq.
SOURCE      Austwickia sp. TVS 96-490-7B
  ORGANISM  Austwickia sp. TVS 96-490-7B
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Dermatophilaceae; Austwickia.
REFERENCE   1  (bases 1 to 42292)
  AUTHORS   Bruer,T., Sarker,S., Lynch,S., Jack,C., Helbig,K., Isberg,S. and
            Tscharke,D.C.
  TITLE     Draft genome assembly of Dermatophilus crocodyli, causative agent of
            dermatophilosis in saltwater crocodiles and a proposed taxonomic
            reassignment to Austwickia crocodyli
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 42292)
  AUTHORS   Bruer,T., Sarker,S., Lynch,S., Jack,C., Helbig,K., Isberg,S. and
            Tscharke,D.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-2021) Immunology and Infectious Disease,
            Australian National University, Garran Road, 131, Canberra, ACT
            2601, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: SPAdes v. 3.13.2
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly :: GCA_900187045.1; GCA_003391095.1;
            GCA_012277275.1
            Genome Coverage                   :: 115.0x
            Sequencing Technology             :: Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019331795.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 02:33:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,297
            CDSs (total)                      :: 3,245
            Genes (coding)                    :: 3,183
            CDSs (with protein)               :: 3,183
            Genes (RNA)                       :: 52
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 62
            CDSs (without protein)            :: 62
            Pseudo Genes (ambiguous residues) :: 0 of 62
            Pseudo Genes (frameshifted)       :: 14 of 62
            Pseudo Genes (incomplete)         :: 53 of 62
            Pseudo Genes (internal stop)      :: 9 of 62
            Pseudo Genes (multiple problems)  :: 13 of 62
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 11640
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHPZL010000025.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11640
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11640
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11640
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4693:6640](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4694..6640
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            246..1043
                     /locus_tag="KEM60_RS15100"
                     /old_locus_tag="KEM60_03106"
     CDS             246..1043
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013429.4"
                     /locus_tag="KEM60_RS15100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03106"
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_219108742.1"
                     /transl_table=11
                     /translation="MPGVAPHLMVENAAHAGFDFVGLQLTPGVGARTGRVYGGAASCEM
                     HAGGVESRRTARALIANGVLLEDISGVLLDGRTEAAQWLPVLEAGAALGAKTLTVTITD
                     PDATRRDDHLAALVHDARGHGIVPAIEPAARSAVPHLMEAADLARRWDCLILPDLLHHH
                     RSRATSAQIAAYADLVVMVQLCDVAPLAGGPRSPRVLPGDGIADIGAFLSAFPDRLPVS
                     VEVPWVRSGRRDAASWARTAFAASRASVEAAGLFAAWGSVESW"
     gene            complement(1188..1868)
                     /locus_tag="KEM60_RS15105"
                     /old_locus_tag="KEM60_03107"
     CDS             complement(1188..1868)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KEM60_RS15105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KEM60_03107"
                     /product="hypothetical protein"
                     /protein_id="WP_219108744.1"
                     /transl_table=11
                     /translation="MIRRTLSLASGAVALGTIALIMPSAVATAAPVAPANSDTSVPALP
                     IVKEQHKRPVQKNLLNPKPVCNAWEDSRVVIERAQKSFEPVGAVEMRNDTTATIPLTQT
                     LARTHSFTAGISGDVGGQFASAVKATIAPTFAFTMSWNAGQVIGPYQVPAGKTARASYG
                     FGVITFDGTHQFCKLDGTWSKPTRVNGRAPLASTVRVQLYSDPSDVLNARRAENVPTDQ
                     RQAR"
     gene            complement(2117..2797)
                     /locus_tag="KEM60_RS15110"
                     /old_locus_tag="KEM60_03108"
     CDS             complement(2117..2797)
                     /EC_number="5.1.3.9"
                     /GO_function="GO:0009385 - N-acylmannosamine-6-phosphate
                     2-epimerase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012804459.1"
                     /locus_tag="KEM60_RS15110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03108"
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="WP_219108745.1"
                     /transl_table=11
                     /translation="MSAVLDLLRHRLIVSCQAYPGEPLRHPETMAQMAQAAVIGGAAGI
                     RAQGLADISFITGRVDVPVIGLWKSGHEGVFITPTVRHARAVLDAGATIVALDGTRRPR
                     PDGLTLAQTVTALRESHPTSSIMADCGSLDDALAAADAGADLIGTTLAGYTPERASTPG
                     PDLELLQLITDALPDIPVIAEGRIHTPDHARAALLAGAFAVVVGTAITHPTTLTGWFAD
                     AMTH"
     gene            complement(2847..4022)
                     /locus_tag="KEM60_RS15115"
                     /old_locus_tag="KEM60_03109"
     CDS             complement(2847..4022)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025228.4"
                     /locus_tag="KEM60_RS15115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03109"
                     /product="exo-alpha-sialidase"
                     /protein_id="WP_219108747.1"
                     /transl_table=11
                     /translation="MSPSRHALRALALAITAPVLLFSVPASADPGSPPYAEQDLAVGGQ
                     GGFPNYRIPAVAVSPGGHILVSYDGRPQSNDAPGPNSILQRRSQDGGLTFGPQQTVHGG
                     KNSPREGYSDPSFVVDQQTKSVFNFHVLSYDQGFAGSRPGTDPHDRQVLHAEVSRSDDD
                     GQTWTHQTITAQITPDPTWRSRFATSGNGIQLRYGAHAGRLVQQFTIIDGGKNQRAVSV
                     YSDDHGATWTAGAAVGTGMDENKVVELSDGRLMMNSRDSARSGYRKIAYSQDGGATWGE
                     VSIDKNLIDPANNASLIRAYPDAPQGSAQAKVLLFSHAASSTSRTNGTIRMSCDDGKTW
                     PVSKVFQPGQTAYTSLAVLPDGTIGLAYEPGHNGIRFARFDLSWLGQTCQS"
     gene            4207..4377
                     /locus_tag="KEM60_RS15120"
     CDS             4207..4377
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KEM60_RS15120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_219108749.1"
                     /transl_table=11
                     /translation="MAKPRSGQHHLPTIGLHRAADVHRLWNADAADPLTAHSSDLRRVF
                     DSTHIPGATTY"
     misc_feature    4693..4708
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.2"
                     /tool="antismash"
     gene            4694..6640
                     /locus_tag="KEM60_RS15125"
                     /old_locus_tag="KEM60_03111"
     CDS             4694..6640
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="KEM60_RS15125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03111"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_219108751.1"
                     /sec_met_domain="TIGR03975 (E-value: 6.1e-165, bitscore:
                     541.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISLVNMPWALVDVPSLALGILREVVTRRHPHMQVDVIHANLDY
                     VDWIVSRREFTLADYQYLALDSYFQGIGDWVFAGALHDDPTWQADALRTAPQLTSEQIH
                     CATDLRSLAKPFVTELIDQLITTQPDVVGFTSTFQQNVAALAAAKELKQRDPEVTIVFG
                     GANCDDKQGAAVLRNFGFLDLVVRGEGEKAFPDLLEVLERHGRHAPHELFADIPGLCRR
                     APSGDILIVPMGSQPLMPQDMSRPDFRGYIDRLAASHAHDWVEPKLVVEGARGCWWGER
                     HHCTFCGLNGSSLQFRSKAPEVFYDEVVGLVREHQVLDMFVVDNILDMGYMRTFISQLI
                     ESGHDLRLQYEIKANMKKDQLRSLVEAGVVIVQPGIENLSSRVLALMDKGVTGCLNVRM
                     LRDAASVGLSVAWNYLYGFPGETEQDYLPLVAQFPALHHLPPLGGVTRIAIERFSPFFD
                     RPDLGFSPLSPHPQYARNYDLPVDELTDLAYLFVGPSHGINEDVADQIRAATNRWQECY
                     PDAVLTGTDLGDQILLRSRRVDYDWDVQWITDPAEIALFRALEQPRSLVSLAAQSFGPS
                     GSGQLHSSTLHEILDRWLGWGVVFTEDGYYIHVVPDDTNQHLLRFDCHRSHRHTPDKDD
                     AHRNPDAQQVAQR"
     gene            6637..7317
                     /locus_tag="KEM60_RS15130"
                     /old_locus_tag="KEM60_03112"
     CDS             6637..7317
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.3"
                     /locus_tag="KEM60_RS15130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03112"
                     /product="DUF5825 family protein"
                     /protein_id="WP_219108752.1"
                     /transl_table=11
                     /translation="MTATITGNPRTTTIPLIVWGHHDVDVPVPAVSPDLIIGDHIPPAG
                     VAIAQRVDEWVRRGVRRVQLPEVVDLTSKYDGRDVVTMLMTVAELTSRGMSVDWELDLT
                     ANMSTWVGITHLAPPRVLHGDADGTILAQWRDAFYVDQCLYRHGPGFVQVRDRRDGTLR
                     CIVIDDPAYLHACTALIQGCQTHEVPADILDDYLEEMLVAVVGAWAWWLPYRVRRWPDP
                     SFAV"
     gene            complement(7346..8068)
                     /locus_tag="KEM60_RS15135"
                     /old_locus_tag="KEM60_03113"
     CDS             complement(7346..8068)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006503494.1"
                     /locus_tag="KEM60_RS15135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03113"
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_219108754.1"
                     /transl_table=11
                     /translation="MTTPVRRVGVWSTTEEIKRYIIEAGLRPGDPVPTEAELGAILGVS
                     RSSIREAIRTLASLDIVEVRHGHGTYVGAMSLAPLVNGMVFRLTLDAAHTLQSLRDVVT
                     TRISLDLALADDVVACHRGRKDPDLHRLVADMRAHSAAGRSFLQEDCAFHTALLHHIDN
                     RIIAELAGAFWEIHTRAVPLLGISPPEDLSETVEAHAAILHAVETGDRDGYVAAVHAHY
                     APLVRAIDRKVSSLEQSG"
     gene            8332..9942
                     /locus_tag="KEM60_RS15140"
                     /old_locus_tag="KEM60_03114"
     CDS             8332..9942
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010849240.1"
                     /locus_tag="KEM60_RS15140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03114"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_370626386.1"
                     /transl_table=11
                     /translation="MNVLAHQTSRRGFLQLTGAMGLAATLAATVSGCASRDNTTGTSQG
                     PAGPLAKDGTLTAAISYELGTNGYDPMSTSAALTIAANWHTMEGLTEIDPATRKTYPAL
                     ARELPTATGTSVDIALRDGATFHDGSPVTADDVVFSFERVQDPANKSLYAQFIPFVDKV
                     VKKDDRTVTLTLKHPTAVLAARLSVVKIVPKVAAADKKSFDAMPVGSGPYRMTDNGASS
                     KQIVFERFDKYTGPRPARAKTMKWQIIPDAATRTNAIQSKSVQVVDSVPYLSVDQLKAS
                     SKVESVQGFGLLFAMFNHSSGNPFATKENRQGFLTAIDMDKVVKTALLGQATPATSFLQ
                     EGHPDYQRAKTVYTFDAAKAKDIFAKTGLKKIRMLCTDHDWVKKCTPIIAESLKSAGVD
                     VDFVEKKSADVYNTIDGKPEAYDVVLAPGDPSVFGNDPDLLLRWWYAGDTWTEQRMHWK
                     GQPSYTKVQELLQEALTATDTAAQKKTWGELFDLLSDELPLYPLFHRKSPTAWDPTTLV
                     DFAPIALTGLSFVNVGSTK"
     gene            9955..10920
                     /locus_tag="KEM60_RS15145"
                     /old_locus_tag="KEM60_03115"
     CDS             9955..10920
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010849241.1"
                     /locus_tag="KEM60_RS15145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KEM60_03115"
                     /product="ABC transporter permease"
                     /protein_id="WP_219108756.1"
                     /transl_table=11
                     /translation="MSSVLRLVGRRLVALPVMVLGVTFLVFFVMSFSPADPARLALGES
                     ASPDALAAYRTEHGLDQPLLVRYGLFLSGMVQGDLGTTSGNTPVTDVIATAFPITLQLT
                     FLGLLIAVVLATVFGVLAALYRDRWPDQAIRVVSILALATPSFWLAILLIQWLGQVPGG
                     FGIFPALILAWVPFGADPATYLTNVALPAFALGVPVAGSLTRVVRTAMVEELDKDYVRT
                     AIGSGIPRSEVIAHNVLRNALITPITVLGLRVGYLMGGAVIIEIIFNIQAMGQLILDGV
                     TRNDVFLVQGVTLTVALAFIVINIVVDLLYVLVNPRIRSI"
     misc_feature    11151..11166
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.03"
                     /tool="antismash"
ORIGIN
        1 ggtggccgaa cgtccaccgg cagtatgtgc gcaaaaacgg cgttcccatc catcacgact
       61 ggacgtccga cctgaccggc tcttatcgtc gtgccgttca ccagggggga agcaccgcgg
      121 gacgtcttga tcgttcggga ggggtgcatg actgttcaag aaatggttta gacatggctg
      181 gatgtgatgg gggtcgagca atccgcccgt ggggcggacg accattagga ctggcagcgg
      241 cgtccatgcc cggtgtcgct ccgcatctga tggtcgaaaa tgccgcccac gctggattcg
      301 acttcgttgg tctgcaactc acccctgggg tcggcgcccg caccgggagg gtgtacggcg
      361 gagccgcgtc ttgcgagatg cacgctggtg gagtggaatc tcggcgtacc gctcgggcat
      421 tgatcgcgaa cggtgtcctg cttgaggaca tcagcggggt gctgctggac ggccggaccg
      481 aagccgcgca gtggctgcct gtcctggaag ccggagccgc cctcggggca aaaaccctca
      541 ccgtgacgat caccgaccct gacgccactc gacgagacga ccatctcgcc gccctcgtcc
      601 acgacgcccg cggccacggg atcgtccctg ctatcgaacc ggcagcacgc agcgccgtac
      661 ctcacctgat ggaagcagca gatctggctc gacgatggga ttgcctgatc ctgcccgatc
      721 tgctgcatca tcaccgcagc cgcgccacct ccgcccagat cgccgcctac gccgacctgg
      781 tggtgatggt ccaactgtgc gacgtggcgc ctctggccgg tgggcctcgt tcaccgcggg
      841 tgctgcctgg tgacggaatc gccgacatcg gcgccttcct cagtgccttc ccggaccggt
      901 tgccggtcag tgtggaggtg ccttgggtgc gctctggacg aagagatgcg gcttcttggg
      961 cacgtacggc gttcgccgca tctcgggcca gcgtcgaagc cgcagggctt ttcgccgcct
     1021 ggggcagcgt cgaatcgtgg tgatacctcg gccacggccg gtcggggcag ggttccggcc
     1081 ggccggaccg tgggagatga cgaccttcac gtcggtaggg ggcgtcggcg gatgctaagg
     1141 gggagcggcc gacgacatgc agtgctggtg gtctcaggaa tagctggtta gcgggcctgc
     1201 cgctgatcgg tggggacatt ttccgcccgc cgcgcattca agacatcgga cgggtcagag
     1261 tagagctgga ctcgtacggt gctcgccaac ggggcccgac cattgacccg ggtgggctta
     1321 ctccaggtgc cgtccaactt gcagaactgg tgggtcccat caaaggtgat caccccaaag
     1381 ccgtagctgg cccgcgccgt cttccctgca ggcacctggt acgggccaat cacctggcca
     1441 gcgttccagg acatggtgaa cgcgaacgtc ggagcaatcg ttgctttcac tgcgctggcg
     1501 aactggccgc ccacgtcgcc gctgatcccg gcggtgaagc tgtgggtgcg agcgagggtc
     1561 tgggtcaggg ggatggtggc ggtggtgtca ttgcgcatct cgacagcccc gactggttcg
     1621 aaggatttct gcgcacgttc aatgacgacc cggctgtctt cccaggcgtt gcagacgggc
     1681 ttggggttga gcaggttttt ctggaccggc cgtttgtgct gctctttgac gatggggagc
     1741 gcgggcacgc tggtgtcgga gttggccggg gcgaccggcg cggcggtggc gaccgcggac
     1801 ggcatgatca gtgcgatggt tccgagtgct acagcccctg aggccagact gagggtacgg
     1861 cgaatcatcc gtgtctcctg tcggttctgg tccggcggcg gacccgccag accagaccac
     1921 agctactccc tgccgaccgt tcattcaaga catttgacca agtcttgagc cgatagttag
     1981 cagttgttca caccgccaaa actgctagtg ccgtagcttt ttccgatttg cggggaatgt
     2041 cctttcgtgg atgaacgtca tagggctttt cccaagatgg cgtcaatggc tgacgtgacg
     2101 tcgcctgggg cggtgatcag tgagtcatgg catcggcgaa ccatccggtg agggtggtgg
     2161 ggtgtgtgat cgcggtcccg acgacaacgg cgaaggctcc ggcgaggagc gctgctctgg
     2221 cgtggtcggg ggtgtggatc cggccttcgg cgatcaccgg gatgtcaggc agagcgtcgg
     2281 tgatgagctg gagcagttcc aggtctggcc caggggtgct ggcccgttca ggggtgtatc
     2341 cagccagggt tgtcccgatc aggtcggctc cggcgtctgc ggcggctaag gcgtcgtcga
     2401 gtgatccgca gtcggccatg atcgacgagg tggggtggct ctcccgaagc gcagtgacgg
     2461 tctgggcgag ggttaatccg tcaggtctgg ggcggcgggt gccgtccaga gcgacgatcg
     2521 tggccccggc gtcgaggaca gcccgggcat ggcgcactgt cggggtgatg aagacaccct
     2581 cgtgaccgct tttccacagg ccaatgacag ggacgtcgac gcggccggtg atgaaggaga
     2641 tgtccgccag cccttgggcg cggatgccgg cggcgccccc gatgacagcg gcctgtgcca
     2701 tttgagccat ggtttcgggg tggcggagcg gttcccccgg gtaggcctgg caggacacga
     2761 tcaggcggtg acggagaagg tcaagtacag cggacatggg ttccttcgac gtgggtccgg
     2821 tggcgggatg tgtcgtggct gcgatgtcag ctctggcagg tctgtcctag ccaggacagg
     2881 tcgaatcggg caaagcggat gccgttgtgg ccgggttcat aggccaggcc gattgtgccg
     2941 tcgggtagca ccgccagtga ggtgtaggcg gtctgaccgg gctggaacac cttggacacc
     3001 ggccaggttt tgccatcgtc gcagctcatc cggatggtgc cattggtacg ggatgtggat
     3061 gaggcggcat gggagaacag cagcactttg gcttgggcgc tgccctgcgg cgcgtccggg
     3121 taggcgcgga tgagggaagc attgttggcg gggtcgatga ggtttttgtc gatgctcacc
     3181 tcaccccagg tggcaccgcc gtcctgggag tatgcgatct tgcgatatcc agagcgggcg
     3241 gagtcgcggg agttcatcat gagtcgtccg tcggagagct cgacgacttt gttctcgtcc
     3301 atccccgttc ccaccgcggc cccggctgtc caggtggcgc cgtggtcgtc ggagtacacc
     3361 gagaccgcgc gctggttttt gccgccatca atgatggtga actgttggac cagtcgacct
     3421 gcgtgagcgc cgtaccgcag ttggatgcca ttcccggagg tcgcgaatcg ggagcgccag
     3481 gtcgggtccg gggtgatctg cgcggtgatg gtctggtggg tccaggtctg gccgtcgtca
     3541 tcggaacggg acacttcggc gtgcaggacc tgccggtcgt gcgggtcggt gccaggtcgg
     3601 gacccggcga agccttggtc gtagctgagc acatggaagt tgaagaccga tttagtctgc
     3661 tgatccacca caaagctggg atcggaatag ccctctctgg ggctgttttt cccaccgtgc
     3721 acggtctgtt gaggaccgaa ggtcagaccg ccgtcctggg atcggcgttg caggatgctg
     3781 ttgggaccgg gggcgtcatt gctctgaggt cgtccgtcgt aggagaccag gatgtgcccg
     3841 ccaggactga ctgcgacggc ggggatgcgg tagttcggga atccgccctg tccgccgacg
     3901 gcgaggtcct gctcggcgta cggcggtgat ccggggtcag cggacgctgg gacggagaag
     3961 agcagcaccg gggcggtgat cgccagggcg agagcgcgaa gcgcatgccg agaaggggac
     4021 atcgtcattc cttagtggga cgaaggtggc ctcacagtac gacatcagat gtccgatgtc
     4081 aggtgattcc ggcggcacga tctgtcgatg gcgatgcgct gaagagtcca gcaacaacgt
     4141 tgccgtcgta agaagttcac tcgccatcca tcgttctggt gcggtgagct ccgtagcgtg
     4201 acgtccatgg ccaagccccg cagcggccaa caccacctcc ccaccatcgg ccttcaccga
     4261 gccgctgatg tccatcgact ctggaacgcc gacgccgcag accccctgac cgcgcacagc
     4321 agcgacctac gccgagtctt cgactcgacg cacatccctg gcgccacgac gtactgagaa
     4381 tcccagagac gtccacatcc ctgcagatcc agccccacag tgatcgcacc ctaggccccg
     4441 gtccgtcacc cggcgtgccg gtcccgcccc gtcatgaggg aggaggtgtt tcacgatgcg
     4501 caagaccaca gtgcacaaca acccgctcga tctcgccagc cccgatcgtg ccatccgcat
     4561 caagatcatc atcgaagcct gacggccgag gaatcaccgg ggtcggctct ggcgcagcag
     4621 ggaccctccc gttgctgcgc cagagtcggc gccacaccgg accacgatca cctcgactgt
     4681 gtgagggacc gctatgaaaa tcagcctcgt caacatgccc tgggccctcg tcgacgtccc
     4741 atccctggcc ctgggaatcc tccgagaagt agtgacccga cggcatcccc acatgcaggt
     4801 cgatgtcatc cacgccaatc tcgactacgt cgactggatc gtctcacgcc gagagttcac
     4861 cctcgcggat tatcagtacc tcgccctgga ctcctacttc cagggcatcg gagactgggt
     4921 ctttgccggt gcactccacg acgaccccac ctggcaggcc gatgcacttc gcaccgcacc
     4981 tcagctgaca tcagaacaga tccactgtgc gacagacctg cgcagcttag ccaaaccgtt
     5041 cgtgaccgaa ctcatcgacc agctcatcac cacccaacct gacgtcgtcg gattcacctc
     5101 aacgttccag cagaacgtcg cagcgctcgc ggctgccaaa gagctcaaac agcgcgaccc
     5161 tgaggtgacg attgtcttcg ggggagcgaa ctgcgacgac aagcaaggtg cggccgtgct
     5221 gcgcaacttc ggttttctcg atctcgtggt gcgcggcgaa ggcgagaagg ctttccctga
     5281 tcttcttgag gtcttagaac gtcatggtcg tcacgctccg catgaacttt tcgccgacat
     5341 tcccggcttg tgtcgacgcg cgcccagcgg ggacatcctg atcgtcccga tgggttctca
     5401 gccattgatg ccgcaggaca tgtctcgacc tgacttcagg ggatatatcg accgattggc
     5461 ggcgtcgcat gcgcatgact gggtggagcc aaaactcgtc gtcgagggtg cccggggatg
     5521 ttggtggggt gagcggcatc attgcacttt ttgtggcctc aacgggtcct ctttgcagtt
     5581 tcgcagcaag gcgccagagg ttttctatga tgaagttgtc ggcctagtcc gcgagcatca
     5641 ggtgcttgat atgtttgtgg tcgacaacat cttggatatg gggtatatgc ggacatttat
     5701 ctcccagctg atcgagtctg gccatgatct acggctccag tatgagatca aggccaatat
     5761 gaagaaggat caacttcggt cgctggtgga ggctggggtg gtgatcgttc agccgggtat
     5821 tgagaatctc agttcacgag tgctggccct gatggataaa ggggtcactg gttgcctgaa
     5881 tgtgcggatg ctgcgggatg cagcgagcgt gggattatcg gtcgcttgga attatttgta
     5941 cggatttcct ggggagactg agcaggacta cctccccttg gttgcacaat tccctgcctt
     6001 gcatcatctt ccccctttag ggggcgttac ccgtatcgct atcgaaaggt tcagtccctt
     6061 tttcgatcgc ccagatctcg gattctctcc gctgtcgccg catccgcaat atgcgcgtaa
     6121 ttacgacctg ccagtcgacg aactcactga tctagcctat ctttttgtcg gtccctccca
     6181 tggcatcaat gaggacgttg ccgaccagat ccgagcagcg acgaatcggt ggcaggagtg
     6241 ctatcccgac gctgttttga ccggcactga cctcggagac cagatactcc tgaggtctcg
     6301 tcgtgttgat tatgattggg atgtccagtg gatcaccgac ccggcagaga tcgcgctatt
     6361 cagagcgttg gaacaacccc gctctctggt gtcattggcc gcgcagtcct tcgggccgtc
     6421 tggatctggc cagctgcaca gctcgaccct ccacgagatc ttggaccgat ggctggggtg
     6481 gggggtggtt ttcaccgaag acggctatta catccatgtg gtgcccgatg acactaacca
     6541 gcatctgctc cgattcgact gccatcggag ccaccgacac acccccgaca aggacgacgc
     6601 ccaccgcaac cctgatgcgc agcaggtggc tcagcgatga cggccacgat cacggggaat
     6661 ccgcgcacca ccacgatccc gctgatcgtg tggggtcacc acgacgtcga cgtgccagtg
     6721 ccagcagtgt caccggatct gatcatcggc gaccacatcc cgccagcagg ggtggcgatc
     6781 gctcagcggg tcgacgaatg ggtacgccgc ggtgtccgtc gggtgcagct gccggaggtc
     6841 gtcgacctca ccagcaagta cgacggccga gatgtcgtga cgatgttgat gacggtagcg
     6901 gagctgacca gccgggggat gagcgtcgac tgggagctgg atctcaccgc caacatgtcc
     6961 acctgggtgg gaatcactca tctagcgcca cctcgtgtcc tgcacggcga cgctgacggg
     7021 acgatcctcg cgcagtggcg cgacgccttc tacgttgatc agtgtctcta ccgtcacggt
     7081 ccgggtttcg tgcaagtccg cgaccgtcgc gacgggacct tacggtgcat cgtcatcgac
     7141 gatccggcgt acctacatgc ctgtaccgcc ctcatccagg gatgccagac ccatgaggtg
     7201 cctgcggaca ttctcgatga ctatctcgaa gaaatgctgg tggcagtggt cggtgcgtgg
     7261 gcttggtggc ttccttatcg ggtccggcgg tggcccgacc cgtccttcgc tgtctgaggg
     7321 gtgcggtcct tctggcggag tcgactcacc ctgactgctc caggctggag accttgcggt
     7381 caatggcccg caccagtggt gcatagtgcg cgtggacagc agcgacatag ccgtcacggt
     7441 cgcctgtttc tacggcgtgc aggatggcgg cgtgggcctc caccgtctcg gaaagatcct
     7501 cgggcgggct gatccccaac agcggtacgg cgcgggtgtg gatctcccag aacgcacccg
     7561 ccagttccgc gatgatccgg ttgtcaatgt ggtggagcag cgccgtgtgg aaggcgcaat
     7621 cctcctgaag gaacgaccgt ccggccgcgc tgtgggcgcg catgtctgcg acgagccggt
     7681 gcagatcagg gtccttcctg ccgcggtgac aggcgacgac atcgtcagcg agcgccaggt
     7741 ccagggaaat ccgagtggtc accacgtccc gcaaactctg caaggtgtga gcggcgtcca
     7801 aggtcagtcg gaagaccatc ccgttgacca gtggggccag gctcatcgct ccgacgtacg
     7861 tgccatgccc gtgtcggacc tccacgatgt ccagggacgc gagggtgcga atggcctctc
     7921 tgatggatga ccgggatacc ccgaggatcg cgcccagctc ggcctctgtg ggcacgggat
     7981 cacccggccg tagaccggcc tcgatgatgt agcgcttgat ctcctcggtg gtcgaccaca
     8041 cacccacgcg tctgaccggg gtcgtcatcg ggctcctcac ttcctgaccg ggcgcagggc
     8101 agcgccggtg cagatccatc ttgacggggg atgggggtga cggccgacag gggaggtcgg
     8161 cgggtcgtta gtcccgatag gcggagccga cacaggtgct cggatgggtt gacccctccc
     8221 ggtgggcgtc gtatcgtcac ggtatcaccg tcggatgtca gacgtccgac gtcaggcaat
     8281 gtcgccgggc ggggccactc accacactcc cgccgcagaa aggtgcccac cgtgaatgtg
     8341 ctcgcccacc agacctccag gcgcggattc ctccaattga ccggcgcgat gggcctcgcc
     8401 gcgaccctcg ccgccactgt ctccggctgc gcctcccgcg acaacaccac cggcaccagc
     8461 caaggtcccg ccgggcccct ggccaaagac ggcaccctca ctgccgcgat ttcctacgaa
     8521 ctcggcacca acggctacga ccccatgagc acctcggcag cgctgaccat cgccgccaac
     8581 tggcacacca tggaaggcct cactgagatc gaccccgcca cccgcaagac ctatcccgcg
     8641 ctcgctcgtg agttgcctac tgcgactggg acgagtgtcg atatcgcgct gcgtgacggc
     8701 gctacattcc acgacggcag tccagtcact gctgatgatg tggtcttctc atttgagcga
     8761 gtccaagatc ccgcaaataa gagcttgtac gcccagttca ttccgtttgt cgataaagtc
     8821 gtcaagaagg atgatcggac cgtcactctg acgctgaaac atcccactgc agtcctcgct
     8881 gcgcgcctgt cagtggtcaa gattgttccg aaggttgctg ctgctgacaa aaaatccttc
     8941 gatgcgatgc cggtgggatc tggtccttac cggatgactg ataacggtgc ttcttccaaa
     9001 cagatcgtgt ttgaacgatt cgacaagtac accggccccc gaccggctcg cgccaaaacc
     9061 atgaaatggc agattatccc ggacgctgcg acccgcacca atgcgatcca atccaagagt
     9121 gtccaggtcg ttgactcggt gccctacctc tctgtcgacc agctgaaagc cagttccaag
     9181 gttgaatcag tccagggctt cgggctcctg tttgccatgt tcaaccactc ctcaggtaat
     9241 ccgtttgcca cgaaagaaaa ccggcagggc ttcctgacgg ctatcgacat ggacaaggtc
     9301 gtgaagaccg cactacttgg ccaagccacc ccggctacct cattcctcca ggaaggccac
     9361 cccgactatc agagagcgaa gacggtctat acctttgacg cagccaaagc taaagacatc
     9421 ttcgccaaaa ctgggctgaa gaagatccgc atgctgtgca ccgaccacga ctgggtgaag
     9481 aaatgcaccc cgatcatcgc agaatccctt aaatctgccg gtgtagatgt tgacttcgtc
     9541 gagaagaaat cagccgatgt ctacaacacc atcgacggca aacccgaggc ctacgacgtg
     9601 gtcctcgccc ccggcgaccc tagcgtcttc ggcaacgacc ccgacctatt gctgcgctgg
     9661 tggtacgccg gcgacacctg gaccgagcag cggatgcact ggaagggcca gccgtcgtac
     9721 acgaaggtcc aagaactcct ccaggaagca ctcaccgcga cggataccgc cgcgcaaaag
     9781 aagacctggg gcgaactgtt tgacctgctc agcgacgaac tgccgctgta tcccctgttc
     9841 caccgcaaga gtcccaccgc atgggacccg acaactctgg tcgatttcgc gcccatcgcg
     9901 ttgaccgggt tgtctttcgt caacgtcggt tccaccaagt aaggcggctg gtcggtgtcc
     9961 tctgtgcttc gtctggtcgg acgccgactg gtcgctcttc ccgtgatggt gctgggcgtc
    10021 accttcttgg tgttcttcgt gatgtccttc tcaccagccg acccggctcg tctcgccctg
    10081 ggcgaatcgg cgtcgccgga tgccctcgcg gcgtaccgca ctgagcatgg actggaccag
    10141 ccgctgctgg tgcgatatgg cctgttcctc agcggcatgg tgcaaggcga cctcgggacc
    10201 acgagcggca acacgccagt caccgatgtg atcgccaccg cgttccccat caccttgcag
    10261 ttgactttcc ttggcctact catcgcggtg gtccttgcga ccgtgttcgg agtgctagca
    10321 gcgctctacc gtgaccggtg gcctgatcag gcgattcgcg tcgtgtcgat tctcgccttg
    10381 gcgactccgt cgttctggtt ggcgatcctg ctgatccaat ggttggggca ggtgccgggc
    10441 ggatttggga tcttccccgc gttgatcctg gcgtgggtgc cgttcggggc agacccggcg
    10501 acgtatctca ccaatgtggc cctccccgcg tttgcgctgg gagtcccggt cgcgggttcg
    10561 ttgactcgcg tggtgcgcac cgcgatggtc gaagaactcg acaaggacta cgtccgtacg
    10621 gcgatcggct ccggcattcc ccgctccgaa gtgatcgccc acaacgtgct gcgcaacgca
    10681 ctgatcaccc cgatcaccgt gttaggtctg cgcgtgggct acctgatggg tggcgccgtc
    10741 atcatcgaaa tcatctttaa cattcaagcg atggggcagc tgatcctcga cggggtgacc
    10801 cgcaacgacg tcttcctcgt gcaaggggtg acgttgacgg tggcgttggc attcatcgtc
    10861 atcaatatcg tcgttgatct gctatatgtg ctggtcaacc cacggatcag gagcatctga
    10921 catgcgccgc gccctgacct cccgcctgga gtcatccgcc ggtggccgcc tcgccggtct
    10981 gcgtacgttg ccgttgtcct cccagatcgc ggtgggcttc ctctcgctga tcgtgcttgc
    11041 cgcactatgc gcgccgctcg tggcaggtga ccccttagcg accggaacgc cagtgcaatg
    11101 gcccggcgcg gagcacctgt ttggcaccga cgccatcggc cgagacgttt ttgcccgagt
    11161 ggtctggggc gccagatcgt ccctggcgat tgggttagcc gccaccggcg ctgccttggc
    11221 cgccgccgca gtgctgggat cggtagcagc cacagctggc aaagccacct cagagatcct
    11281 gatgcgggtc ctcgacatcg tgatgagctt tccggggatc gctttggctg ccgtgttcgt
    11341 cgccgtgttc ggcaacgcct tacccgtgct gatcttggcg atcggattcc tatacgtccc
    11401 acaactgtcc cgagtggtgc gggccaacgt gatcgcccag ttcggtgagg attacgtcgc
    11461 tgccaatcga gtgatggggg cgcggatccc atcgatcctg ctgcggcacg tagcccgcaa
    11521 ctgtgtggca ccgatcatgg tgttcgcgac agtgctggtc gcagacgcga tcgtgttcga
    11581 agcatcgctg tcgttcatca acgctggagt caagccgccg caccccagct ggggcaacat
//
