LOCUS       NZ_CP024972            23696 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8578489
            Orig. end                         :: 8602185
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23696
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="35"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23696
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23696
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13696]"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13696
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            157..1029
                     /gene="rpsB"
                     /locus_tag="CVV72_RS39875"
                     /old_locus_tag="CVV72_39780"
     CDS             157..1029
                     /GO_component="GO:0015935 - small ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032886.1"
                     /locus_tag="CVV72_RS39875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39780"
                     /product="30S ribosomal protein S2"
                     /protein_id="WP_034310929.1"
                     /transl_table=11
                     /translation="MAVVTMKQLLDSGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQQ
                     TLTYIDRAYEFIKETVAHGGTIMFVGTKKQAQEAIAAEASRVGMPYVNQRWLGGMLTNF
                     QTVHKRLLRLKELESQEQTGGFAGLTKREILTLTREKDKLEKTLGGIRDMAKVPSIVWI
                     VDTKKEHIAVGEARKLNIPVVAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVVAEAAA
                     AGLMARSSRNGSSADAKPEAGVATDEPLAEWEKELLAGSETAAADAKEAAAATEAATEA
                     PAEQATASS"
     gene            1123..1947
                     /gene="tsf"
                     /locus_tag="CVV72_RS39880"
                     /old_locus_tag="CVV72_39785"
     CDS             1123..1947
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tsf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074497.1"
                     /locus_tag="CVV72_RS39880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39785"
                     /product="translation elongation factor Ts"
                     /protein_id="WP_044850881.1"
                     /transl_table=11
                     /translation="MANYTAADVKRLRELTGSGMMNCKKALEENDGDFDKAVEFLRIKG
                     AKDVGKRAERATAEGLVAGDGGVLIELDSETDFVAKNEDFQALAAKIVEVAKAEKTSDV
                     EKLKAASLDGKTVDEQVQELAARIGEKLELRRVAAYEGTTTTYLHRRGADLPPAVGVLI
                     EYTGEGEAAAEAARGAAMQVAALKAKYLTREEVPAEIVENERRVAEATAREEGKPEQAM
                     PKIIEGKVNAYYKDNVLLEQPSVKDNKKTVKALLDEAGVSVSRFARFEVGQA"
     gene            2040..2783
                     /gene="pyrH"
                     /locus_tag="CVV72_RS39885"
                     /old_locus_tag="CVV72_39790"
     CDS             2040..2783
                     /EC_number="2.7.4.22"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0033862 - UMP kinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223864.1"
                     /locus_tag="CVV72_RS39885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39790"
                     /product="UMP kinase"
                     /protein_id="WP_005154669.1"
                     /transl_table=11
                     /translation="MGVRVEGGYRRVLLKLGGEMFGGGSIGVDPDVVHSVAQQIADVAR
                     TGVQIAVVIGGGNYFRGAELSQRGMDRDRADYMAMLGTVMNCLALQDFLEKEGLPTRVQ
                     TAITMGQVAEPYIPRRAERHLEKGRVVIFGAGVGMPYFSTDTAAAQRALELGCEAVLMA
                     KAVDGVYTADPKSDPTAEMFHEISHREVLERDLKVADATAFSLCMDNNMPIIVFNLLTE
                     GNIARAVSGERIGTLVDTPADGVPA"
     gene            2835..3392
                     /gene="frr"
                     /locus_tag="CVV72_RS39890"
                     /old_locus_tag="CVV72_39795"
     CDS             2835..3392
                     /GO_function="GO:0008135 - translation factor activity, RNA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="frr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943637.1"
                     /locus_tag="CVV72_RS39890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39795"
                     /product="ribosome recycling factor"
                     /protein_id="WP_034310934.1"
                     /transl_table=11
                     /translation="MIDETLLDAEEKMEKAVSVAKEDLSSVRTGRAHPGMFSRIVVEYY
                     GAPTPLNQMASVNIPEARMALIKPYDQTSLNAIEKAIRESDLGVNPSNDGNVIRIVIPQ
                     LTEERRKEMVKVAKAKGEDARVSIRSVRRKAKEELDRIKKDGEAGEDEVVHAEKELQNL
                     TDTYSHKVDELVKHKEAELLEV"
     gene            3392..4288
                     /locus_tag="CVV72_RS39895"
                     /old_locus_tag="CVV72_39800"
     CDS             3392..4288
                     /EC_number="2.7.7.41"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336218.1"
                     /locus_tag="CVV72_RS39895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39800"
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="WP_219149852.1"
                     /transl_table=11
                     /translation="MSQVSEEREDRVENPEPVPAEKPEPAKKVSRAGRNLPAAIGVGLL
                     LGAAIVTSLLTVRFLFIGIIAIAIAVGTIELAGALKRAAGIRIALVPVLVGGQAMIWLA
                     WPYGREGALTAFVLTVLVCLLWRLPGGADGYLRDISASVFAAAYIPLFGAFAAMLVPPA
                     DGVGRVLAFMIGVVASDTGGYIAGVLGGKHPMAPSISPKKTWEGFAGSLVAGVVAGSLT
                     LSLLLDGHAWQGVLFGAAIVCTATLGDLVESLIKRDLGVKDMGNMLPGHGGLMDRLDSL
                     LPSAVVSWLLLSAFVPL"
     gene            4334..5881
                     /locus_tag="CVV72_RS39900"
                     /old_locus_tag="CVV72_39805"
     CDS             4334..5881
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005153236.1"
                     /locus_tag="CVV72_RS39900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39805"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_255632409.1"
                     /transl_table=11
                     /translation="MRTQRLSKRLLSMALSVMTLGALTTTVAEAGESPVVRTDSGPVRG
                     VDTGEYRSFHGIPFAAPPVGDLRWAPPRSPGPWTAVRDASKPGPRCAQEAGLGPAPSDN
                     EDCLYLNVISPAKPAWKPRPVMVWVHGGSFTYGAGSDYDFKRMALGGDVVVVTVNYRLG
                     VFGFFGHPELGRDSGVFGLQDQQAALRWVQRNARAFGGDPGNVTLFGESAGSMSACAQL
                     ASPSAAGLFHRVIIQSSPCTLNWPDGGFVPGLPAGTPYLSRTDVEAMGADAAGKLGCAD
                     VACLRRLPVKALVNQPFAPPAFGTGLLPEHPAEALKAGRFARVPVLTGITRDEARMFVA
                     MFAGHPFTEQQYQGLLRTAFGEKAPLVAARYPSAKHGGPSMAFADAMTDRIWGCTQLET
                     ERLLRERTRTFGYEFADRDGPSLLPAPPGMSMGASHGAELAYLSDVVAPPAELTRAQRE
                     LGARMIRYWTAFARTGDPNGEELPKWRPSPRTQSLAPDAIGPVDLAAVHDCRFWAGI"
     misc_feature    complement(4373..4386)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.22"
                     /tool="antismash"
     gene            complement(5896..6741)
                     /locus_tag="CVV72_RS39905"
                     /old_locus_tag="CVV72_39810"
     CDS             complement(5896..6741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630575.1"
                     /locus_tag="CVV72_RS39905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39810"
                     /product="VOC family protein"
                     /protein_id="WP_219149854.1"
                     /transl_table=11
                     /translation="MSLGSAAHTSVIPSGIPCWIELACRDETAAQTFYSGLFDWEYVVR
                     RDPATPTGRYSIATLNGVPAGGLYRAGSGGPSGWSVHISVPQAAAAAEWVDSLGGRVTL
                     GPVAIPHRGNIVHAVDACGAHVVFWEPPATWEFATGVPNTFSGADLNTHDGAAADHFYC
                     RLFDYTSHQIGDGATLDYAEWLIEHEPVLYRYVMGSEYRPDTPPHWMVYIELDPARGAD
                     AAAGQALMLGGAVVVQPYDTPYGRMAILADPDGSVFAVIDHSRAVEGWGTAEVDDPYDD
                     "
     gene            6857..7696
                     /locus_tag="CVV72_RS39910"
                     /old_locus_tag="CVV72_39815"
     CDS             6857..7696
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336215.1"
                     /locus_tag="CVV72_RS39910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39815"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_219149856.1"
                     /sec_met_domain="PCMT (E-value: 6.4e-05, bitscore: 21.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWFPRALSSLRRGGEEVLPSPNIWYYQKAYEVENRAQDVDDEIW
                     RVLAGYRDWSGADVLDIGCGDGFHLPRFAATARSVVGIEPHEPLVRDARKRVGRLENVE
                     VRHGRAQRLPLPDAAFDVVHARTAYFFGPGCEPGLREAERVLRPGGLMMVVDLDVASEP
                     YGRWMRLDLPHYDPPGVEKFFTRQGFDCRKVMTRWLFEDAAAMEAVLKIEFSAPVAAKA
                     IAEVRRLNEVSSASGEKRMTLPVGYRVHTRAKPTGLVVPGHSASSSGAASSASPRMP"
     gene            complement(7642..8250)
                     /locus_tag="CVV72_RS39915"
                     /old_locus_tag="CVV72_39820"
     CDS             complement(7642..8250)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223869.1"
                     /locus_tag="CVV72_RS39915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39820"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_219149858.1"
                     /transl_table=11
                     /translation="MRRRPFPPEHGRPAFGPWARGGFGDFPPGPGGPGHRHRHGRRGGP
                     GRRGKRGDVRAAILALLSEQPRHGYEIIREIGERSGGFWKPSPGSVYPTLQLLADEGLV
                     ISKDENGKKLFELTESGRAAAEQQDAVPPWEQIAHDVDPVEVNLRKAGATLAAAVAQVM
                     HAGTESQQARTVDVLNEARRTIYGILGEAEDAAPDEDAE"
     gene            complement(8339..8803)
                     /locus_tag="CVV72_RS39920"
                     /old_locus_tag="CVV72_39825"
     CDS             complement(8339..8803)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226214.1"
                     /locus_tag="CVV72_RS39920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39825"
                     /product="N-acetyltransferase"
                     /protein_id="WP_255632410.1"
                     /transl_table=11
                     /translation="MRSELDDVYRRVYREPPYLEGEDDVARFGVLFAEHATLPGFAMTT
                     VREGGALGGFAYGVRQEAGWWPERATPPPSWLDGEEVFYVYELALLPELRGRGLGRALL
                     DDLLKERPERFAVLASRVEAPARRLYRRWGWRKVGEFDSGGIDLLALDLS"
     gene            complement(8793..10001)
                     /locus_tag="CVV72_RS39925"
                     /old_locus_tag="CVV72_39830"
     CDS             complement(8793..10001)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226215.1"
                     /locus_tag="CVV72_RS39925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39830"
                     /product="MFS transporter"
                     /protein_id="WP_219149860.1"
                     /transl_table=11
                     /translation="MAAADLLGLPSTRGRFPLIAAQSVDALGTGLFLPFAVVYFHAAKG
                     LSLTAVGAALSIAAMLALPSGPLAGRLIDRFGPGRMVITANLIRAVTFTGYVFAGEAWH
                     LVVLAAVTFWGEGLFWPSTGALVAQVADDGQRARWYAMERALRNVGIGLGGLLGAAMVA
                     WGGTGGYTVIVLVNAASFVVAAVLVASWRAPASTPPETGSEAVPAGGYRKVLADRIFRG
                     VLVSVFVFALCDLALTVLLSAYVLDGLKLPAWQPGVLFAINTVLVVLAQTVVSRRVERR
                     RMPRTLQISAAVWAVSFVLFALVPTGHPTTAFLVLTLAVTVFTGAELLQAPTSSALTVA
                     IAPARLRGRYLGLEELVWSAARVIAPATFTWLLSHGAALPWLVLIGCCGVAIVVLGRLN
                     RAL"
     gene            complement(10001..12169)
                     /locus_tag="CVV72_RS39930"
                     /old_locus_tag="CVV72_39835"
     CDS             complement(10001..12169)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226216.1"
                     /locus_tag="CVV72_RS39930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39835"
                     /product="YcaO-like family protein"
                     /protein_id="WP_219149862.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-60, bitscore: 203.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.2e-77, bitscore:
                     260.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSEEVRPRLDGIEITDLEPELCFLVTPNGGQFYIAAPTREFRAW
                     ASRCDGTRTRAELLAGMPPDYEEMMEILEADGCLRPGPDAGTEDIASTSILLTGSPVLI
                     EPLAEILGGSGYASVETVPYFHDLSERDIGNTVVVAAFDHPAYTESIALDALCAGSGVR
                     WLPLRRERGRVIAGPAIAPGGIDFADVVARRRSAAQDPRVVEAFLSASSDSTPLRPGDA
                     RWALTTFAVHLERWLSGGRSGMTTGEIELNPADLTEIRRPILPVPDRARPVPDATDPEL
                     LVDDQTGIVTGVGEIPPAPGMPARLRVCAVDVADMRRVTNWPNDRQAFGTSWHDFDLAR
                     QSAIGEAVERYCGSWLAPEREVCFGSYKQFDRYGVPALDPQRLNLYSATQYRSRGFPFA
                     PLTQDTECSWVEGFSHTTGEPVWVPAFLFSNERRPGEASFADPLIAGLASGTTEEHAVT
                     SGLEEVLERDTTMLWWANTPRLGRLTIPDEIRSLIADATDDYDVTLIHLDNEFDVPVVA
                     AVVLDRVKRWLSIGFATRPDALEAAKKALAEGFTLQHTCRALDDERELSGMRRDLPHLG
                     NLKPHRADRRYLDSYREDFADVVDLLCQQQIYLDPRAVKRVAPWVMDLPARGWDDLPAL
                     GERRLKAYQARVEARGFEVISVDLTTCDVAAAGFRAAHTLVPGLVSNFPAGSPLWGNGR
                     IAGAAVTLGWRDEPLAEHELNVFPLPHA"
     gene            complement(12258..12392)
                     /locus_tag="CVV72_RS41840"
     CDS             complement(12258..12392)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004561011.1"
                     /locus_tag="CVV72_RS41840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_255632411.1"
                     /transl_table=11
                     /translation="MISTYERPAAVVVHNRAVVHNRAVVHNRAVVHNRAVVHNRSAAK"
     misc_feature    12420..12433
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.19"
                     /tool="antismash"
     gene            12590..13696
                     /gene="rlmN"
                     /locus_tag="CVV72_RS39935"
                     /old_locus_tag="CVV72_39840"
     CDS             12590..13696
                     /EC_number="2.1.1.192"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0030488 - tRNA methylation [Evidence IEA]"
                     /GO_process="GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rlmN"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336213.1"
                     /locus_tag="CVV72_RS39935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39840"
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="WP_034310951.1"
                     /sec_met_domain="PF04055 (E-value: 1.7e-22, bitscore: 79.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALPLVFDAPKRGLPPRHLADLSAAERAAAVAELGEKPFRAKQL
                     SNHYFSRLTVNPEEMTDIPAASREKLVGDLMPTLLTEIKALACDDGTTRKTLWRAHDGT
                     LLESVLMRYPDRATLCISSQAGCGMACPFCATGQGGLDRNLSTAEIVDQVRAAAAVMRD
                     GSMPGGPGRLSNIVFMGMGEPLANYKRVVAAVRRITDPAPDGLGIGQRSVTVSTVGLAP
                     AIRKLADEKMQVRLAVSLHTPDDELRDTLVPVNERWSVDEVLSAARYYADTSGRRVSIE
                     YALIRDVNDQPWRAELLAKRLRQHLGQLVHVNVIPLNPTPGSKWDASPKPVEREFVRLV
                     NAGGVACTVRDTRGQEIAAACGQLAAEN"
     gene            13731..14036
                     /locus_tag="CVV72_RS39940"
                     /old_locus_tag="CVV72_39845"
     CDS             13731..14036
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032876.1"
                     /locus_tag="CVV72_RS39940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39845"
                     /product="hypothetical protein"
                     /protein_id="WP_219149864.1"
                     /transl_table=11
                     /translation="MYAPSLLDPAAEELKLADVIGHGATGVAREARTLLGDRFSSVTFM
                     YVLMRAFEVEYMAARDASRWHEFHGGPYALSDADLEALLAPWLGAHRRPAVASGTV"
     gene            14410..15225
                     /locus_tag="CVV72_RS39945"
                     /old_locus_tag="CVV72_39850"
     CDS             14410..15225
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336209.1"
                     /locus_tag="CVV72_RS39945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39850"
                     /product="DUF1206 domain-containing protein"
                     /protein_id="WP_219149866.1"
                     /transl_table=11
                     /translation="MSATKARQVRHNTAVQVLGRIGMGCYGLVYLLIGYLAVRVAVGSG
                     GQEADGRGAITEVGSTAVGGVLLWVLAAGLVAYGLWQALLAAVGYTWIDKRRTRTVKRV
                     TSGVRCVVGISLGVYAARVAAGAGQQGSGDQKQQEFTARLLGLPAGPFLVTVVAVVVFG
                     VAVGSVVKGVRRTFEQDLDLSRLPSGTRRWVERLGRIGYVARGVVFGVVAVLVGFAALT
                     HDAARSGGLDAALRTLAAQPFGTVLLLVVAAGVAAFGVYCFGAARAQRG"
     gene            complement(15317..16090)
                     /locus_tag="CVV72_RS39950"
                     /old_locus_tag="CVV72_39855"
     CDS             complement(15317..16090)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032873.1"
                     /locus_tag="CVV72_RS39950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39855"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_219149868.1"
                     /transl_table=11
                     /translation="MRGIPIDEVDHLDRAVVAIRTDYPPGHRIRPHRHRRAQFLYSATG
                     SMRVETADGTWTIPTRRAVLVPPETVHQVFTTTVSTRSLYIEPKAVPWFPRRCQVVEVS
                     ALLRELLNEAVVVPELYTPRGRDAAIIGLTLHEIRRSAPVRLDLPLPRHDRLRTLCESF
                     LDDPDIHDPVAGWADRLHVSERTLNRLFTAETGLSFARWRQRACVLHSLSLLSDGLPIA
                     GIAASLGYESPAAFSTMFTRLLGTSPKDYRAAVSR"
     gene            16182..16985
                     /locus_tag="CVV72_RS39955"
                     /old_locus_tag="CVV72_39860"
     CDS             16182..16985
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032872.1"
                     /locus_tag="CVV72_RS39955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39860"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_219154418.1"
                     /transl_table=11
                     /translation="MLIEISVLLGFGCLSGVTTVLFGFGGGFITVPVVYAFALAQPEHA
                     LGAMHVAVATSTAVMVVNAGSATLAQLRAGRLRRDYLWPLVAFIGLGAVLGSFAATVAD
                     ESVLRWLFVAYLALTIADSVLRKGFVSRRDDSLPRALGGITTTAGGTGIGAVASFLGVG
                     GSVLTVPLMRRKGLPMADATALANPLSLPVAVIGTAVYAFAATGTAPAPAHLGYIDLVA
                     AGALLCGSLPTIAVTRRVVGRIPDRAHAIAYLALLVAALIAIIVR"
     gene            17113..19098
                     /locus_tag="CVV72_RS39960"
                     /old_locus_tag="CVV72_39865"
     CDS             17113..19098
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032871.1"
                     /locus_tag="CVV72_RS39960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39865"
                     /product="peptidase S8/S53 subtilisin kexin sedolisin"
                     /protein_id="WP_219149870.1"
                     /transl_table=11
                     /translation="MKLRSITKRMFVLGLLTALGTTGATSVATAEPQLPPAEVNATGLP
                     HGGWDPVGPNSVGGLLAVSPAGLAMMVPSPPALWLSTDRGASWTARRGLPEDTAIQGFF
                     ADPVNPDRMLAVGNSPGGMPGEWHGMLLRTTDRGQTWETLREWYPDGAFGMATDPAGRV
                     VVVQNLDTLSVSIDGGEHWNDVPRTWPREGIAAPTGGLRLTMVGDDAYFTTVYPEYALW
                     AVRGVSGKEPRAELVYRTNGEINQVASDGERFVVTVGPELHGSTDGGKTWTVLRRDPGE
                     QPLREPHFVGGRLYIATYNDIDVSSDFGRTWTRKPVPAPGEGISDMIDLPASPGKPATT
                     LISSFYRGVYADGGKSGYQQIGVPAESIRDLVTTGNLLRESVVAAGVQEIYNTPLPRGK
                     VSAADRVWQSHPTDRLHEDARLSVSPGRPDVVWQVTRNGFALDVLRSGDGGRTWQFAAK
                     AKEGLPRAIFTHPADPDRLLVSAFAPSGYVLYRSDDAGKTWEKLASDKGFIAFAGDPWN
                     PDRVWGGDFDGLSRSDDGGKTWTHVTSQPVSSISVSRWGGGRVLIGGAGIHLSEDGGRT
                     FRRVHDGEDPREISRILPDPFDFRVWFASNATGGGVLRSTDFGRTWSPVPGALPDPRVL
                     SLAISADGRYLFAGTAQSGAYRLKLY"
     misc_feature    complement(17114..17128)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    complement(17133..17146)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.82"
                     /tool="antismash"
     misc_feature    17133..17146
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.27"
                     /tool="antismash"
     gene            19179..20360
                     /locus_tag="CVV72_RS39965"
                     /old_locus_tag="CVV72_39870"
     CDS             19179..20360
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (20-385). E-value: 6.7e-52.
                     Score: 168.5. Matches aSDomain:
                     nrpspksdomains_CVV72_RS39965_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032870.1"
                     /locus_tag="CVV72_RS39965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39870"
                     /product="cysteine desulfurase-like protein"
                     /protein_id="WP_219149872.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.9e-49, bitscore:
                     165.8, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.8e-05,
                     bitscore: 20.6, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.6e-06, bitscore:
                     24.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDVAALRLHFPSLADGTAFFDGPAGTQTPRPVADAIARTLTGP
                     LSNRGKVSPSELNAENAVAAFRSAYADFFGVPAEGVVHGRSATQLTYDFSRHLAKSWRE
                     GDEIVVSRLDHDANVRPWVQAAERTGMTVRWLDIDPLTTELDLDSLVLTERTRLVAVTA
                     ASNVLGTKPPIRRIADLAHDAGALLFVDGVHYAAHDLVDVPALGADFFVCSPYKFLGPH
                     CGVLGASPALLETVEPDKLVPSPGTVPERFEFGTLPYETLAGATAAVDFLAALDPGSAG
                     SRRDRLANSMNSLHEHENLLRTRLEKELGDAVTVHGKAADRTPTVLMSLGGREREAQKH
                     LAERNVVAPAGSFYAYEVFAALKLEDPALRVGMAPYTSTEDVDRLLDGLSAFG"
     aSDomain        19239..20333
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS39965_Aminotran_5.1"
                     /evalue="6.70E-52"
                     /label="CVV72_RS39965_Aminotran_5.1"
                     /locus_tag="CVV72_RS39965"
                     /protein_end="385"
                     /protein_start="20"
                     /score="168.5"
                     /tool="antismash"
                     /translation="FFDGPAGTQTPRPVADAIARTLTGPLSNRGKVSPSELNAENAVAA
                     FRSAYADFFGVPAEGVVHGRSATQLTYDFSRHLAKSWREGDEIVVSRLDHDANVRPWVQ
                     AAERTGMTVRWLDIDPLTTELDLDSLVLTERTRLVAVTAASNVLGTKPPIRRIADLAHD
                     AGALLFVDGVHYAAHDLVDVPALGADFFVCSPYKFLGPHCGVLGASPALLETVEPDKLV
                     PSPGTVPERFEFGTLPYETLAGATAAVDFLAALDPGSAGSRRDRLANSMNSLHEHENLL
                     RTRLEKELGDAVTVHGKAADRTPTVLMSLGGREREAQKHLAERNVVAPAGSFYAYEVFA
                     ALKLEDPALRVGMAPYTSTEDVDRL"
     gene            20476..21027
                     /locus_tag="CVV72_RS39970"
                     /old_locus_tag="CVV72_39875"
     CDS             20476..21027
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS39970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_39875"
                     /product="hypothetical protein"
                     /protein_id="WP_219149874.1"
                     /transl_table=11
                     /translation="MIDSGRFAMRFRSVAASVLLGCALCVAPAALGAGPQSLAIQPCPE
                     VNDPPDYKISNGAKAWMKTNLRSDYLRGPGTITYNKTTTSSVNASITGTTSAEAGVIFA
                     KASVSLAVSVGASYSKSDSWSYSATVPAGKTLRLQQYKEARSFTVQKYRIVPPCKVKYL
                     WKKNAVAPVKSPSYLWQLIG"
     gene            21163..21990
                     /locus_tag="CVV72_RS39975"
                     /old_locus_tag="CVV72_39880"
     CDS             21163..21990
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630552.1"
                     /locus_tag="CVV72_RS39975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39880"
                     /product="acetylxylan esterase"
                     /protein_id="WP_219149876.1"
                     /transl_table=11
                     /translation="MGKLRARILIAGMVVLATVGITPAATAEAGIASRWSEPGPYAVTV
                     EALDSAHTVYRPSRLEEHPVILWGNGTGANPKIYDGLLRHLASHGFVVAAADTPNAGSG
                     QEMLAGATTLIAENSRPGSPYQGKIDTAHIGATGHSQGGGGAIAAGADSRVTTTIPIEP
                     GPQGSVAALKGPSFFLGGQFDTIVVPGLLVIPRYRVADQVPAIYGELGGATHFTPVGDG
                     GGFRGAITAWFRFWLSGDEGARAEFFGASCGLCRDGAWSDVRRNAKALAVPGA"
     gene            22058..22612
                     /locus_tag="CVV72_RS39980"
                     /old_locus_tag="CVV72_39885"
     CDS             22058..22612
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336203.1"
                     /locus_tag="CVV72_RS39980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_39885"
                     /product="cysteine hydrolase family protein"
                     /protein_id="WP_219149878.1"
                     /transl_table=11
                     /translation="MTTLADRPNTALLVVDVQNGVVDEAYERDSVIANIGALVGRARRE
                     GVPVVWVRHSDEELVRGSEEWRIVGELDRAESEPLVEKSYGDSFEDTDLEKVLAERGVG
                     RLVVAGAETDACIRSTLHGAMVRGYDVTLVGDAHTTFDKSAWGAPTPEQVIAHTNLYWR
                     HQVAPGRKGGTVKTEDVDFRG"
     misc_feature    22984..22998
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    23037..23048
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
ORIGIN
        1 gcacacggcc cggcggtccc tggggtactt cgctcccggg tccgggcccg agcatcggca
       61 ccagggcgat cggccacccg gccgagagcg acgaaccgag caagcgcgtt ccggcggagc
      121 cgggcgcgca cgacacagaa gaggttgatt ccggcaatgg ccgtcgtcac catgaagcag
      181 ctgctcgaca gcggcgtgca cttcgggcac cagacccgtc ggtggaaccc gaagatgaag
      241 cgctacatct tcaccgagcg caacggcatc tacatcatcg acctgcagca gacgctgacc
      301 tacatcgacc gtgcgtacga gttcatcaag gaaaccgtcg cgcacggcgg caccatcatg
      361 ttcgtcggca cgaagaagca ggcacaggaa gccatcgcgg ccgaagcctc gcgcgtgggc
      421 atgccctacg tgaaccagcg ctggctcggc ggcatgctga ccaacttcca gacggtgcac
      481 aagcgtctcc tccgcctgaa ggagctcgag tcgcaggagc agaccggcgg cttcgccggc
      541 ctgaccaagc gcgaaatcct cacgctcacc cgtgagaagg acaagctcga gaagaccctc
      601 ggcggtatcc gcgacatggc caaggtgccg agcatcgtgt ggatcgtcga cacgaagaag
      661 gagcacatcg ccgtcggcga ggctcgcaag ctgaacatcc cggtcgtcgc gatcctggac
      721 accaactgcg acccggacga ggtcgactac ccgatcccgg gtaacgacga cgccatccgt
      781 tcggccgcgc tgctgaccaa ggtcgtggcc gaggccgccg ccgccggtct gatggcccgc
      841 tccagccgca acggttcctc cgccgacgcc aagcccgagg ccggcgtcgc cacggacgag
      901 ccgctggccg agtgggagaa ggagctgctc gccggctccg agaccgccgc cgcggacgcc
      961 aaggaagccg ccgccgcgac cgaggccgcc accgaggctc cggccgagca ggccaccgcc
     1021 tcctcctgat cgaccccgcc cgcagggccg cctcccggcg accctgcggg tgacttcccc
     1081 acaagacttt ctcgtacctg aaaaaggacg gacacaccca cgatggcgaa ctacaccgcc
     1141 gcagacgtga agcgtctccg ggagctcacc ggctccggca tgatgaactg caagaaggcg
     1201 ctggaggaga acgacggcga cttcgacaag gccgtcgagt tcctgcgcat caagggcgcc
     1261 aaggacgtcg gcaagcgcgc cgagcgcgcc accgccgagg gcctcgtcgc cggtgacggc
     1321 ggcgtgctga tcgagctcga ctccgagacc gacttcgtcg cgaagaacga ggacttccag
     1381 gccctcgccg cgaagatcgt cgaggtcgcg aaggccgaga agaccagcga cgtcgagaag
     1441 ctgaaggccg cctcgctcga cggcaagacc gtcgacgagc aggtccagga gctggccgcc
     1501 cgtatcggcg agaagctcga gctgcgccgt gtcgccgcct acgagggcac caccaccacg
     1561 tacctgcacc gtcgcggtgc ggacctcccg cccgccgtcg gcgtgctcat cgagtacacc
     1621 ggtgagggcg aagccgccgc cgaagccgct cgtggcgccg ccatgcaggt cgccgcgctc
     1681 aaggccaagt acctcacccg cgaagaggtc ccggccgaga tcgtcgagaa cgagcgccgc
     1741 gtcgccgagg cgaccgcccg tgaagagggc aagccggagc aggccatgcc gaagatcatc
     1801 gagggcaagg tcaacgcgta ctacaaggac aacgtcctgc tcgagcagcc gtcggtcaag
     1861 gacaacaaga agaccgtcaa ggccctgctc gacgaggccg gcgtgtccgt gagccggttc
     1921 gcccggttcg aggtcggcca ggcctgatcc aggcgcggaa cacaagaatc accactgtgc
     1981 cccgtctccg tccatcgggg acggggcaca gtcgggttca gagcattagg gagggcgaca
     2041 tgggtgtccg ggtcgaaggc ggataccggc gggtgctgct gaagctgggc ggcgagatgt
     2101 tcggcggcgg ttccatcggg gttgatccgg atgtggtgca ctcggtcgct cagcagatcg
     2161 ccgacgtcgc gcggacgggc gtgcagatcg ccgtcgtgat cggcggcggc aactacttcc
     2221 gcggcgcgga gctgtcgcag cgcggcatgg accgcgaccg cgcggactac atggcgatgc
     2281 tcggcaccgt catgaactgc ctggcgttgc aggacttcct ggagaaggag ggcctgccga
     2341 cccgcgtgca gaccgccatc accatgggac aggtcgccga gccgtacatc ccgcgccgcg
     2401 ccgagcgtca cctggagaag ggccgcgtcg tcatcttcgg cgccggggtc ggcatgccgt
     2461 acttctcgac cgacaccgcc gccgcgcagc gcgcgctcga actcggctgt gaggccgtct
     2521 tgatggcgaa ggccgtcgac ggcgtctaca ccgcggaccc gaagagcgac ccgaccgccg
     2581 agatgttcca cgagatcagc caccgcgagg tgctggaacg ggatctcaag gtcgccgacg
     2641 ccaccgcgtt cagcctgtgc atggacaaca acatgccgat catcgtgttc aatctgctca
     2701 ccgaggggaa catcgcccgc gcggtcagtg gtgagaggat cggcaccctg gtcgacaccc
     2761 ccgccgacgg ggtgcccgcg taggcctgct ctgatcttcg caatcggtac gcatacacaa
     2821 ctacgggagt tgccgtgatc gacgagaccc tcctcgacgc cgaggagaag atggaaaaag
     2881 cggtgtccgt cgccaaggag gacctgtcgt cggtacgcac cggccgggct catcccggga
     2941 tgttctcgcg cattgtcgtc gagtactacg gcgcgccgac cccgctgaac cagatggcga
     3001 gcgtcaacat ccccgaagcc cggatggcgt tgatcaagcc gtacgaccag acctcgctca
     3061 acgccatcga gaaggcgatc cgcgagtcgg acctcggggt caacccgagc aacgacggca
     3121 acgtgatccg catcgtcatc ccgcagctca ccgaagagcg ccgcaaggag atggtgaagg
     3181 tcgccaaggc caagggtgag gacgcccgcg tctcgatccg cagcgtccgc cgcaaggcca
     3241 aggaagagct cgaccggatc aagaaggacg gcgaggcggg cgaggacgag gtcgtccacg
     3301 ccgagaagga actccagaac ctcaccgaca cctacagcca caaggtcgac gagctggtga
     3361 aacacaagga agccgagcta ctcgaggtct gatgagccag gtgagcgagg aacgcgagga
     3421 ccgggtggag aacccggaac cggttccggc cgaaaagccg gaaccggcga agaaggtttc
     3481 ccgcgccggc cgcaacctgc ccgccgcgat cggggtcggg ctgctgctgg gcgcggcgat
     3541 cgtcacgtcc ctgctcaccg tccgctttct gttcatcggc atcatcgcga tcgccatcgc
     3601 ggtcggcacg atcgagctgg ccggggcact gaagcgcgcg gcgggcatcc ggatcgcgct
     3661 ggtcccggtg ctcgtcggcg gtcaggcgat gatctggctg gcgtggccgt acggccgtga
     3721 aggcgcgctg acggcgttcg tgctgacggt gctcgtctgc ctcctgtggc ggttgcccgg
     3781 cggcgcggac ggctacctgc gcgacatcag cgcgtcggtc ttcgccgccg cgtacatccc
     3841 gcttttcggt gccttcgccg ccatgctcgt cccgcccgcg gacggtgtcg gccgcgtgct
     3901 ggcgttcatg atcggtgtgg tcgcttcgga caccggcggc tacatcgccg gtgtactggg
     3961 cggcaagcat ccgatggcgc ccagcatcag cccgaagaag acctgggaag gattcgccgg
     4021 ttcgctcgtg gccggtgtgg tcgccggctc cctgaccctc agccttctcc tcgacggtca
     4081 cgcctggcag ggcgtgctgt tcggcgcggc gatcgtctgc acggcgacgc tgggcgacct
     4141 cgtcgagtcg ctgatcaagc gcgacctcgg cgtcaaggac atggggaaca tgctgccggg
     4201 ccacggcggg ctgatggacc ggctcgactc gttgctccct tccgccgtcg tctcctggct
     4261 gctgctctcc gcattcgtgc ctctttaggc caagtccctg tgacgagtcc ggcgctctgt
     4321 catggtcggg ggcatgcgca ctcaacggct gagtaagcgg cttctgtcca tggcactgag
     4381 cgtgatgacg ctgggggcct tgacgacgac cgtggcggag gcgggcgaaa gcccggtcgt
     4441 ccgcacggat tccggtcccg ttcgaggcgt ggacacgggc gaataccgga gtttccacgg
     4501 cattccgttc gcggcgccac ccgtcggcga cctgcgctgg gcgccacccc gaagtcccgg
     4561 accgtggacc gccgtgcggg acgcgagcaa accgggacct cggtgcgcgc aggaggcggg
     4621 gctcggtccg gcgccgagtg acaatgagga ttgcctgtac ctcaacgtga tcagcccggc
     4681 caagccggcg tggaagccgc gtccggtgat ggtctgggtc cacggtggca gcttcaccta
     4741 cggggcgggc agcgactacg acttcaagcg catggcgctg ggcggggacg tcgtcgtggt
     4801 gacggtgaac taccggctgg gggtgttcgg cttcttcggg catccggaac tcggccgcga
     4861 ctccggcgtg ttcggccttc aagaccagca agccgcactt cgctgggtgc agcgcaacgc
     4921 gcgcgccttc gggggagatc ccgggaacgt cacgctgttc ggcgaatcgg ccggttcgat
     4981 gagcgcctgc gcccagctgg cctccccgtc ggccgcgggg ctcttccacc gcgtgatcat
     5041 ccagagcagt ccgtgcacct tgaactggcc cgacggcggg ttcgttcccg gcctgcccgc
     5101 gggcacgccg tacctgtccc ggacggacgt cgaagcgatg ggtgccgacg cggccgggaa
     5161 actcggctgc gccgacgtcg cctgtctccg gcggcttccg gtcaaggcct tggtgaacca
     5221 gccgttcgcg ccgcccgcgt tcggcaccgg cctgctgccc gagcatccgg ccgaggcact
     5281 gaaggcgggt cgcttcgccc gcgtgccggt gctgacgggg atcacgaggg acgaggcgag
     5341 gatgttcgtc gccatgttcg ccgggcatcc gttcaccgaa cagcagtacc aaggattgct
     5401 acggaccgct ttcggggaga aggcgccgct tgtcgcagcc cggtacccgt cggcgaagca
     5461 cggcggcccg tcgatggcgt tcgcggacgc gatgaccgac cggatctggg gctgcaccca
     5521 gctggagacc gagcgactgc tgcgcgagcg cacccggacc ttcggttacg agttcgcgga
     5581 tcgcgacgga ccctcgctcc tcccggctcc gcccggaatg tccatgggcg cttctcatgg
     5641 cgccgaattg gcctatttgt ccgatgtggt cgcgcctccg gcggaattga cgcgcgcgca
     5701 gcgggaactg ggagcgcgaa tgatccggta ctggaccgcg ttcgcgcgca ccggtgaccc
     5761 gaacggcgaa gaactgccga aatggcgtcc ctcgccgcgg acacaatcgc tggcgccgga
     5821 cgcgatcggc ccggtcgacc tcgcggcggt gcacgattgc cgattctggg cgggaatctg
     5881 accggagcgc ggggctcagt cgtcgtaggg atcgtcgact tcggcggtgc cccagccctc
     5941 gacggcccgg gagtggtcga tcacggcgaa caccgaaccg tccgggtcgg ccaggatcgc
     6001 catccggccg tacggggtgt cgtagggctg gaccacgacg gcgccgccga gcatcaaggc
     6061 ctgtcccgcc gcggcgtcgg cgccgcgggc cggatcgagt tcgatgtaga ccatccaatg
     6121 cgggggagtg tccggccgat actccgaacc catcacgtac cggtacagca cgggttcgtg
     6181 ctcgatgagc cattcggcgt agtcgagggt ggcaccgtcg ccgatctggt ggctggtgta
     6241 gtcgaagagg cggcagtaga agtgatccgc cgccgctccg tcgtgggtgt tgagatccgc
     6301 gccactgaag gtgttcggca ctcccgtcgc gaactcccag gtggcgggcg gctcccagaa
     6361 gacgacgtgt gcgccgcacg cgtcgacggc gtggacgatg ttgccgcgat gggggatcgc
     6421 caccggcccg agcgtgaccc ggccaccgag actgtccacc cattcggcgg cggccgccgc
     6481 ctggggcacc gagatgtgga cgctccagcc ggacggcccg cccgagcccg cgcggtacag
     6541 accaccggcc gggacgccgt tcagcgtcgc gatcgagtag cggccggtcg gcgtcgccgg
     6601 atcacgccgg acgacgtact cccagtcgaa aagcccgctg tagaaggttt gtgcggccgt
     6661 ttcgtctctg cacgcgagct cgatccagca cggaattccc gaaggtatga cggaagtgtg
     6721 ggcggccgag ccgagcgaca tgcggttctc ccttaccggt gggagtaaag tctagtcgct
     6781 gaccgcattg tttccgtgag agatttcgac cggatgaccc cggaaccccg cccggtgtcc
     6841 cttcgttgga gcttccgtgc gctggtttcc ccgagccctc tcctccctcc gccgcggcgg
     6901 tgaggaggtg ttgccgagcc cgaacatctg gtactaccaa aaggcctacg aggtcgagaa
     6961 ccgcgcacag gacgtcgacg acgagatctg gcgcgtgctc gccggatatc gtgattggtc
     7021 cggtgcggac gtcctcgaca tcggctgtgg tgacggtttc catctgccgc ggttcgccgc
     7081 gacggcgcgg tcggtggtcg ggatcgagcc ccatgagccg ctcgtccgtg acgcgcggaa
     7141 acgggtgggg cgactggaaa acgtcgaggt acggcacggg cgtgcgcagc ggcttccctt
     7201 gccggacgcg gctttcgacg tcgtccacgc acgcaccgcg tacttcttcg gccccggttg
     7261 tgaacccggt cttcgtgaag cggagcgggt gctgcggccg ggtgggctga tgatggtcgt
     7321 ggatctcgat gtggcgagtg agccctacgg acgctggatg cggctggatc tgccgcacta
     7381 cgacccgccc ggcgtggaga agttcttcac ccgtcaggga ttcgactgcc gcaaggtgat
     7441 gacgcggtgg ctgttcgagg acgccgccgc gatggaagcg gtgctgaaga tcgagttcag
     7501 cgctccggtc gcggcgaagg cgatcgcgga ggtccggcgc ctgaacgagg tttcgtcagc
     7561 ttccggggag aagcggatga cgctgccggt gggctatcgc gtgcatacgc gcgccaagcc
     7621 caccggcctc gtcgtgccag gtcactccgc gtcctcgtcc ggagcggcgt cctccgcctc
     7681 gccgaggatg ccgtagatcg tccggcgtgc ctcgttgagc acgtcgacgg tgcgggcctg
     7741 ctggctttcg gtgccggcgt gcatcacctg ggcgaccgcc gcggccaggg tcgcgcccgc
     7801 cttgcgcagg ttgacctcga ccgggtcgac gtcgtgggcg atctgctccc acggcgggac
     7861 ggcgtcctgc tgctcggccg cggcgcggcc ggattcggtg agctcgaaca gcttcttgcc
     7921 gttctcgtcc ttgctgatca ccaggccttc gtcggccagc aactgcaggg tcgggtagac
     7981 cgagccgggg ctcggcttcc agaacccgcc gctgcgttcg ccgatctcgc ggatgatctc
     8041 gtaaccgtgc ctcggctgct cggaaagcag cgccaggatc gcggcgcgga cgtcaccgcg
     8101 tttgccgcgc cgtccggggc caccgcggcg gccgtgccgg tgccgatggc ccggtccgcc
     8161 cgggcccggc gggaagtcgc cgaagccgcc gcgggcccaa ggtccgaagg ccggtcggcc
     8221 gtgttctgga gggaagggtc gtcgtcgcat gaggtgaatc ctttctacgt actgtctcga
     8281 cacgttcacg atatatcgga aacagtcgta cggcaacctc tcttcggtga tctgggtctc
     8341 aggagaggtc gagcgcgagg aggtcgatgc cgccggagtc gaactcgccg accttccgcc
     8401 agccccaacg gcggtacagc cgccgagcgg gcgcctcgac gcgggacgcc aggacggcga
     8461 accgctcagg ccgctctttc agcaggtcat cgagcagagc gcggccaagc ccgcgaccac
     8521 ggagctcggg gaggagcgcc agctcgtaca cgtagaacac ctcttcgccg tcgagccagg
     8581 acggcggagg cgtcgcacgt tcgggccacc agccggcttc ttggcgtacc ccgtaggcga
     8641 agccgccgag tgcgccgcct tcgcgcactg tcgtcatggc gaacccgggg agcgtggcgt
     8701 gctcggcgaa cagcacgccg aaccgggcga cgtcgtcctc gccttcgagg tacggcggtt
     8761 cgcggtagac gcggcgatag acgtcgtcca gttcagagcg cacgattcag tctgcccagc
     8821 accacgatcg ccacgccaca acagccgatc agcaccagcc acggcaaagc cgcgccgtgg
     8881 gacagcagcc aggtgaacgt cgccggggcg atcacccgcg ccgcgctcca cacgagttct
     8941 tcgaggccga gatagcggcc gcgcaagcgt gccggggcga tcgcgacggt cagcgcgctg
     9001 ctggtcggcg cctggagcag ttcggcaccg gtgaagacgg tcaccgcgag cgtgagcacg
     9061 aggaacgccg tcgtggggtg cccggtgggc accagcgcga acaggacgaa cgacaccgcc
     9121 cacaccgcgg ccgaaatctg gagcgtgcga ggcatgcggc gccgctcgac ccggcgcgac
     9181 accacggtct gcgccagcac gaccagcacc gtgttgatcg cgaacaggac tcccggctgc
     9241 caagccggca gtttcaagcc gtcgaggacg tacgcgctca gcaagacggt caacgccagg
     9301 tcgcacaacg cgaagacgaa gacgctcacg agtacgccgc gaaagatccg gtcggcgagc
     9361 accttccggt agccacccgc gggaaccgcc tcggatccgg tctcgggcgg ggtgctcgcc
     9421 ggagcccgcc acgacgcgac cagaaccgcg gcgacgacga aactcgccgc gttgaccagg
     9481 acgatcaccg tgtagccgcc ggtgccgccc caggcgacca tcgcggcgcc gaggagcccg
     9541 ccgagcccga tgccgacgtt gcgcagcgcg cgttccatcg cgtaccagcg ggcgcgctga
     9601 ccgtcgtcgg ccacctgtgc caccagcgcg ccggtcgacg gccagaacag gccctcgccc
     9661 cagaacgtca ccgccgccag gacgaccagg tgccatgcct cgccggcgaa gacgtagccg
     9721 gtgaaggtca ccgcgcggat caggttggcg gtgatcacca tccgccccgg cccgaaccgg
     9781 tcgatcagcc gtcccgcgag cggtcccgac ggcagggcca gcatcgccgc gatcgacagg
     9841 gccgctccga cggccgtgag cgacagcccc ttcgccgcgt ggaagtacac gacggcgaag
     9901 ggcaggaaca aaccggtccc cagcgcgtcg acgctttgcg ccgcgatgag cgggaaccgg
     9961 ccgcgagtgc tcggcaggcc gagcagatcg gcggcggcca tcacgcgtgg gggagcggga
    10021 agacgttgag ttcgtgctcg gcgagcggtt cgtcccgcca gccgagggtc accgccgcgc
    10081 cggcgatcct tccgttgccc cacaacggtg atccggcggg gaagttcgag acgagccccg
    10141 ggaccagcgt atgcgcggcg cggaatccgg cggccgcgac gtcgcaggtc gtcaggtcga
    10201 cgctgatcac ctcgaacccc cgggcttcga cccgggcttg gtaggccttg agccgccgtt
    10261 ccccgagggc gggaaggtcg tcccagccgc gggccggcag gtccatgacc cagggagcca
    10321 ctcgcttcac ggcgcgcgga tcgaggtaga tctgttgctg gcaaaggaga tccacgacgt
    10381 cggcgaagtc ttcgcggtac gagtccaggt agcgccggtc ggcccggtgc ggtttgaggt
    10441 tgcccagatg cggcaggtcc cggcgcatgc cggacagctc gcgctcgtcg tcgagggcac
    10501 ggcaggtgtg ctggagcgtg aacccttcgg cgagagcctt cttcgcggcc tccaacgcgt
    10561 ccggccgggt cgcgaagccg atcgacagcc agcgtttcac gcggtcgagt accaccgcgg
    10621 cgaccaccgg gacgtcgaac tcgttgtcca aatggatgag cgtgacgtcg tagtcgtcgg
    10681 tggcgtcggc gatgagcgac cggatctcgt ccgggatcgt gagcctgccg aggcgtggcg
    10741 tgttcgccca ccagagcatg gtcgtgtcgc gctcgaggac ctcttcgagg ccggaggtga
    10801 cggcgtgttc ttcggtggtc ccgctggcga ggccggcgat cagcggatcg gcgaaagacg
    10861 cttcccccgg tcggcgttcg ttcgagaaca ggaacgccgg aacccagacg ggttcgccgg
    10921 tggtgtggga gaagccttcc acccacgagc attccgtgtc ctgggtcagt ggtgcgaacg
    10981 ggaaaccccg ggaccggtac tgcgtggccg agtagagatt cagccgctgc ggatcgagtg
    11041 cagggactcc gtagcggtcg aattgcttgt agctgccgaa gcacacttcg cgctccggag
    11101 cgagccagct tccgcagtag cgctccaccg cttcgccgat ggccgattgg cgcgcgaggt
    11161 cgaagtcgtg ccacgacgtg ccgaacgcct gacggtcgtt gggccagttc gtcacgcggc
    11221 gcatgtccgc gacatcgacc gcgcagaccc gcagccgggc gggcattccc ggggcgggcg
    11281 ggatctcgcc gacaccggtc acgatcccgg tctggtcgtc caccagcagt tcggggtcgg
    11341 tcgcgtcggg aacggggcgg gcccggtcgg gtacggggag gatcgggcgg cggatctcgg
    11401 tgaggtcggc cggattcagt tcgatctcgc cggtggtcat accggatcgc ccgccggaga
    11461 gccagcgttc gagatggacg gcgaaggtgg tcagggccca gcgtgcgtcg ccgggccgaa
    11521 gcggggtgga gtccgaggag gccgaaagga acgcctcgac gacacgcggg tcctgtgcgg
    11581 cggagcggcg ccgcgcgacg acgtcggcga aatcgatgcc gccgggggcg atggccggtc
    11641 cggcgatcac gcggccgcgt tcccggcgca acggcagcca gcgcactccg ctgccggcgc
    11701 acaacgcgtc caaggcgatc gattcggtgt aggcgggatg atcgaaggcc gcgaccacga
    11761 ccgtgttccc gatgtcccgt tcggacagat cgtggaagta gggaaccgtc tcgacgctcg
    11821 catatccgct gccgccgagg atttccgcca agggctcgat gagcacgggc gagccggtga
    11881 ggaggatcga ggtcgaggcg atgtcttccg tcccggcgtc cgggccgggg cggaggcagc
    11941 cgtccgcttc gaggatctcc atcatttcct cgtagtccgg aggcatgccg gccaggagtt
    12001 cggcgcgagt ccgggtgccg tcgcagcggc tcgcccaagc gcggaactcc cgggtgggcg
    12061 cggcgatgta gaactgcccg ccgttgggcg tgacgagaaa gcagagctcc ggttcgagat
    12121 cggtgatctc gattccgtcg agccgcggtc tgacctcttc ggaccccatg gcaaccccat
    12181 cgtctccagg actcccgcct cgccgccgcg atcccggtgc gcgggaccgc ggcggcgcgg
    12241 gcggctttgt cggccggtta cttggcggcg gaacggttgt ggacgaccgc gcggttgtgc
    12301 acgacggccc ggttgtggac gaccgcgcgg ttgtggacca cggcccggtt gtggacgacg
    12361 acggcggcgg gacgctcgta ggtcgagatc atggttcctc cggtaattca ctcggggtcg
    12421 tcacgctccg tggcgtgaca tgaccaagtc tcgggccggc cgtgacctcc cgacgtctcc
    12481 tgatgtgcga tccgcacggt cggcccgggt gcggttcacg tgacctggga aacagcgatc
    12541 cggggcggcc caggcgcggc aaaggtggac atgggacact gagtgagcta tgactgccct
    12601 ccctctcgtc ttcgacgcgc ccaagcgcgg cctcccgccg cgccacctcg ccgacctttc
    12661 cgccgccgag cgggccgctg ccgtcgccga gctgggggag aagccgttcc gcgcgaagca
    12721 gctttcgaac cactacttct cgcggctcac ggtgaacccg gaggagatga ccgacatccc
    12781 ggcggcgtcg cgggagaagc tcgtcggcga tctgatgccg acgctgctca ccgagatcaa
    12841 ggcgctcgcg tgcgacgacg gcaccacgcg caagacgttg tggcgcgcgc acgacgggac
    12901 gctgctggag agcgtgctga tgcgctaccc ggaccgcgcg acgctgtgca tctccagcca
    12961 ggcaggctgc ggcatggcgt gcccgttctg cgcgaccggt cagggcggtc tcgaccggaa
    13021 cctgtcgacc gcggagatcg tcgaccaggt ccgcgccgcg gccgcggtga tgcgcgacgg
    13081 atcgatgccc ggtggccccg gccgtctgtc gaacatcgtc ttcatgggca tgggcgagcc
    13141 gttggcgaac tacaaacgag tcgtggcggc ggtccggcgg atcacggatc ccgcgccgga
    13201 cgggctcggc atcggccagc gttcggtgac ggtgtcgacg gtgggtctcg cgccggcgat
    13261 ccgcaagctg gcggacgaga agatgcaggt gcggctcgcg gtttcgctgc acacgccgga
    13321 cgacgagctg cgggacacgc tggtgccggt gaacgagcgc tggtcggtgg acgaggtcct
    13381 gtccgcggcc cggtactacg cggacacctc cggccgccgg gtgtcgatcg agtacgcgct
    13441 gatccgggac gtcaacgatc agccttggcg tgccgagctg ctggcgaagc ggcttcggca
    13501 gcacctcggc cagctggtgc acgtgaacgt gatcccgctg aacccgacgc cgggcagcaa
    13561 atgggacgcc tcgccgaagc cggtggagcg ggagttcgtc cggctggtga acgcgggcgg
    13621 agtggcgtgc acggtccgtg acacgcgtgg tcaggagatc gcggcggcct gcggtcagct
    13681 cgccgccgag aactgagttc ttccctttca gtgatggaga ttttgtcgtg atgtatgccc
    13741 ccagcctgct ggacccggct gcggaggagc tgaagctcgc ggacgtgatc ggccacggcg
    13801 cgaccggtgt cgcgcgcgag gccaggacgt tgctcggcga ccggttcagc tcggtgacct
    13861 tcatgtacgt cctgatgcgg gcgttcgagg tggagtacat ggcggcgcgg gacgcttcgc
    13921 ggtggcacga gttccacggc gggccgtacg cgttgtcgga cgccgacctc gaagccctcc
    13981 tggcgccctg gctcggtgct caccgccgtc cggcggtcgc gtcgggcacc gtctgagcgg
    14041 gtcgacgcga ccgtcctttg tggatggtcg gtgcgattcg cgccgggtgg gccggtagac
    14101 gagttcctgg acccgccgtc gaaggtacgg ctttcgagca ggtgtgaaac ggcgacgaga
    14161 cggtcctcgg cccgctgcac ctggccgaag gcgacgccgc cccggccggc gtcggtccga
    14221 ttcccgggag cttcgacggc tcggcgtggt caggggccgt cgggctcggc cggcatcgcg
    14281 acaccggcga ctggcttccg gcttaagcgg caccacctcc ctcgcccgct gggccggacg
    14341 gagcagtcac gcggcggtca tggccgtcgg ccgtgacact cgatggtgac tcaggaggag
    14401 gtggaccgga tgtccgcgac caaggcgaga caggtgcggc acaacacggc cgtccaggtg
    14461 ctcggacgga tcgggatggg gtgctacggc ctggtgtatc tgctcatcgg gtacctggcg
    14521 gtgcgcgtcg ccgtcggcag tggcggccag gaggccgacg gccgcggcgc gatcaccgag
    14581 gtcggctcga ccgcggtggg cggtgtgctg ttgtgggtgc tggcggccgg actggtcgcc
    14641 tacggcctgt ggcaggcgtt gctggccgcg gtcggctaca cctggatcga caagcgcagg
    14701 acccggaccg tcaagcgggt gacgtccgga gtgcggtgcg tggtggggat ttccctgggc
    14761 gtctacgcgg ccagggtcgc cgcgggcgcg gggcagcagg gcagcggcga ccagaagcag
    14821 caggagttca ccgcgcgcct gctcgggttg ccggccgggc cgttcctggt gaccgtggtg
    14881 gccgtcgtcg tgttcggcgt cgcggtgggc tcggtggtga agggcgtacg ccggaccttc
    14941 gagcaggatc tcgacctctc gcggctcccg tcgggtactc ggcggtgggt ggagcggctc
    15001 ggcaggatcg gttacgtggc aaggggtgtc gtgttcggag tggtcgcggt actcgtcggt
    15061 ttcgcggcgc tgacgcacga cgcggcccgc tccggcgggc tcgacgccgc tctgcggacc
    15121 ttggccgccc agccgttcgg cacggtgctg ctcctcgtgg tggccgccgg ggtcgcggcc
    15181 ttcggcgtgt actgcttcgg ggcggcgcgg gcgcagcggg gctgagcccg cgcggacgct
    15241 caggaaaacc ggattcctcc gtcgatcgtg accggctgaa ctcccttgtc cgccggggtc
    15301 ggaggggtgt cgtgtctcac cgcgagacag cggcgcgata gtccttcggc gaggtgccga
    15361 gaagccgggt gaacatcgtg gagaacgcgg cgggactctc gtagccgagc gaggcggcga
    15421 tcccggcgat gggaaggccg tccgacagca gcgacaagga atgcaggacg caggctcgct
    15481 gccgccagcg ggcgaaactc agtccggttt cggcggtgaa gagccggttc agcgtccgct
    15541 cgctcacgtg cagccggtcg gcccagccgg cgaccggatc atggatgtcc ggatcgtcca
    15601 aaaaggactc acagagggtg cgcagccggt cgtgcctcgg cagcgggaga tcgagccgga
    15661 ccggggcgga gcggcggatc tcgtgcaggg tcaggccgat gatcgcggcg tcccgtccac
    15721 gcggggtgta cagctccggc acgacgacgg cctcgttcag aagttcccgg agcagcgcgg
    15781 aaacttcgac gacctggcag cggcgcggga accacggcac cgccttcggc tcgatgtaca
    15841 ggctccgggt gctcacggtc gtggtgaaga cctgatggac cgtctccggc ggcacgagca
    15901 ccgcccgccg cgtcgggatg gtccatgtgc cgtcggccgt ttcgacccgc atcgatcccg
    15961 tcgcgctgta gaggaactgg gcccgccggt gccgatgcgg gcggatccgg tgccccggtg
    16021 ggtaatcggt gcggatcgcc accaccgcgc ggtcgaggtg gtcgacctcg tcgatgggga
    16081 tgccgcgcat ctcaccgagc ctacgccggg tgtccgttcc acgaaagaaa ctggcgctct
    16141 ttcgaatgcc cgccgcgccg tggacgccta ccgtcgacgg ggtgctgatc gagatctcgg
    16201 tgctcctcgg gttcggttgc ctgagcgggg tcaccaccgt ccttttcgga ttcggcggcg
    16261 gcttcatcac cgtgcccgtc gtctacgcct tcgcgctcgc gcagccggag cacgcgctgg
    16321 gcgcgatgca cgtggcggtg gccacgtcga ccgcggtgat ggtggtcaac gccgggagcg
    16381 cgaccctcgc gcaactgcgg gcgggacggc ttcgccgcga ctacctttgg ccgctcgtcg
    16441 cgttcatcgg cctgggtgcc gtgctcggct ccttcgcggc caccgtggcc gacgagagtg
    16501 tcctgcgctg gctcttcgtc gcttacctcg cgctgacgat cgccgacagc gtgctccgga
    16561 agggcttcgt gagcaggcgg gacgacagcc tgccgcgtgc gctcggcggg atcaccacca
    16621 cggcgggcgg gaccgggatc ggtgccgtgg cgagcttcct cggggtcggg ggcagtgtcc
    16681 tcaccgtccc gctcatgcgg cgcaagggcc tgcccatggc cgacgcgacc gcgctggcga
    16741 acccgctgag cctgccggtg gcggtgatcg gcacggcggt ctacgccttc gcggcgacgg
    16801 gcacggctcc ggcccccgcc cacctcggct acatcgatct ggtggccgcg ggagcgctgc
    16861 tgtgcggatc gctgccgacc atcgccgtga cgcgccgcgt ggtcggccgg atcccggatc
    16921 gcgcgcacgc gatcgcgtac ctcgccttgc tcgtcgccgc gctgatcgcg atcatcgtcc
    16981 gctagtgatc ggatgagttt gtccgttgtc aagccttgac aagggatcgc cgagcaggca
    17041 aggggttatc gccaagcaaa gatccgacga atcctctatc tcttttcggg aacttgcgcc
    17101 aagatctccc gcatgaaact gagatcgatc accaaacgca tgttcgttct cgggctgctg
    17161 acggctctcg ggaccaccgg ggcgacgtcg gtggccaccg ccgaacccca gctgccgccc
    17221 gccgaggtca acgccaccgg gctgccgcac ggcggctggg acccggtcgg cccgaacagc
    17281 gtcggcgggc tgctggcggt ttcgcccgcc gggctcgcga tgatggtgcc cagtccgccc
    17341 gccctgtggc tctccaccga tcgtggcgcc tcctggaccg cgcgccgggg tctgccggaa
    17401 gacaccgcca tccagggatt cttcgccgat ccggtgaacc cggaccggat gctcgcggtg
    17461 ggcaactcgc ccggcgggat gcccggcgag tggcacggga tgctgctgag gaccaccgac
    17521 cgcggccaga cctgggagac cctgcgcgag tggtaccccg acggcgcgtt cggcatggcc
    17581 acggacccgg cgggccgggt cgtcgtggtg cagaacctcg atacgctgag cgtcagcatc
    17641 gacggcggcg agcactggaa cgacgtgccg aggacctggc cccgcgaggg gatcgccgcg
    17701 cccaccggcg ggctcaggct cacgatggtc ggcgacgacg cctacttcac gacggtgtac
    17761 ccggagtacg cgctgtgggc ggtccgcggg gtcagcggca aggagccgcg ggccgaactc
    17821 gtctaccgga ccaacggcga gatcaatcag gtcgcctcgg acggcgaacg gttcgtggtc
    17881 acggtcggcc ccgagctgca cggatccacc gacgggggca agacgtggac ggtgctacgg
    17941 cgcgatcccg gcgagcagcc cctgcgtgaa ccgcacttcg tcggcgggcg gctgtacatc
    18001 gcgacgtata acgacataga cgtcagctcg gacttcggcc gcacctggac gcgcaaaccg
    18061 gtgcccgccc cgggcgaggg catcagcgac atgatcgacc ttcctgcctc gccgggcaaa
    18121 cccgccacca cgctcatctc ctcgttctac cgcggcgtgt acgcggacgg cggcaagagc
    18181 gggtatcagc agatcggcgt gcctgccgaa tccatccgcg acctcgtgac caccgggaac
    18241 ctcctgcgcg agagcgtcgt cgcggcgggt gtgcaggaga tctacaacac cccgctcccg
    18301 cgcggcaagg tctccgcggc ggaccgcgtg tggcagtcgc atcccaccga ccggctgcac
    18361 gaggacgcgc gcctgtccgt gtcgccggga cggcccgacg tcgtctggca ggtgacccgg
    18421 aacgggttcg cgctcgacgt gctccgcagc ggtgacggcg ggcggacctg gcagttcgcg
    18481 gcgaaggcga aggaggggct ccccagggcc atcttcactc acccggccga cccggaccgg
    18541 ctgctcgtct cggccttcgc gcccagcggc tacgtgctct accggagcga tgacgccggg
    18601 aagacctggg aaaagctcgc gtccgacaag ggcttcatcg cgttcgccgg tgatccgtgg
    18661 aacccggacc gggtctgggg cggggacttc gacggcctgt cccggtcgga cgacggcggc
    18721 aagacctgga cccatgtgac gagccaaccg gtcagttcga tctcggtcag ccggtggggt
    18781 ggcggccgcg tgctcatcgg cggcgcgggc atccacctga gcgaggacgg cggccggacg
    18841 ttccgccggg ttcacgacgg cgaggacccc cgtgagatca gccggatcct gccggatccg
    18901 ttcgatttcc gggtgtggtt cgcgagcaac gcgaccgggg gaggcgtgct gcgcagcacg
    18961 gacttcggcc gcacctggtc gcccgtgccc ggcgcgctgc ccgatcccag ggtgctctcc
    19021 ctggcgatca gcgcggacgg ccggtatctg ttcgccggca ccgcgcaatc cggcgcgtac
    19081 cggttgaagc tgtactgagt ccgagcgctt cgtggccgga gaaagttccg gccacgaagc
    19141 gtttactcgg tccctcttcg aatgtcagag tcgggggcat ggccatcgac gtcgccgccc
    19201 tccggctcca cttcccttcc ctcgccgacg gaaccgcctt cttcgacgga ccagcgggta
    19261 cccagacacc ccggcccgtc gccgacgcca tcgcccggac actcaccggg ccgctgtcga
    19321 accggggcaa ggtcagcccg tccgaactca acgcggagaa cgccgtcgcg gcgttccgat
    19381 ccgcctatgc cgacttcttc ggcgtgcccg ccgaaggtgt cgtccacggc cgcagcgcca
    19441 cccagctgac gtacgacttt tcccggcacc tggccaaaag ctggcgtgag ggggacgaga
    19501 tcgtcgtcag ccgtctcgat cacgacgcca acgtcaggcc gtgggtccag gccgcggagc
    19561 gaaccgggat gaccgtccgc tggctcgaca tcgatcctct gaccaccgag ctcgacctcg
    19621 attccctggt cctcaccgag aggaccaggc tggtcgcggt cacggccgct tcgaacgtcc
    19681 tcggcacgaa gccgcccatc cgccggatcg ccgatctcgc ccacgacgcc ggggcgctgc
    19741 tgttcgtcga cggagtgcac tacgccgccc acgatctggt ggacgttccc gcgctgggag
    19801 cggatttctt cgtctgctcg ccgtacaagt tcctcggccc gcactgcggg gtgctcggcg
    19861 cgtcgccggc cctcctggaa accgtcgagc cggacaagct cgtgccgtcg cccggcaccg
    19921 tcccggaacg gttcgaattc gggacgctgc cctacgaaac gctcgcgggc gcgacggcgg
    19981 ccgtggactt cctcgccgca ctcgacccgg gatcggccgg atctcgacgg gaccggctgg
    20041 cgaactcgat gaactcgttg cacgagcacg aaaacctgct gcgcaccaga ctggagaagg
    20101 agctgggcga cgccgtcacc gtccatggca aggccgccga ccggaccccg accgtcctga
    20161 tgagtctcgg cggccgcgag cgcgaggcgc aaaagcatct cgccgaaagg aatgtcgtcg
    20221 caccggcggg gtccttctac gcctacgaag tcttcgcggc cttgaaactg gaggaccccg
    20281 cgctccgcgt cgggatggct ccgtacacca gtacggagga cgtcgacagg ctgctggacg
    20341 ggctttcggc gttcgggtga aaccacagtg gacagtgcgg gcctgatgga gcgcggccgc
    20401 aacgacacct gcgacccgta actcgaacag gttggatttc cgcgccgccg acgggagccg
    20461 tattaccgtt cgatcatgat cgacagcggg aggttcgcga tgcgtttccg gtcggtggcc
    20521 gcttcagtcc ttctcggttg cgcgctgtgc gtggcgcctg cggcactcgg agccgggcca
    20581 cagtcgctcg cgattcagcc ctgccccgag gtcaacgatc cgcccgacta caagatctcg
    20641 aacggcgcca aggcctggat gaagacgaac ctgcgcagcg actacctgcg cgggccgggg
    20701 acgatcacct acaacaagac cacgacctcc tcggtcaacg cgtccatcac cggtacgacc
    20761 agcgccgagg cgggtgtcat cttcgccaag gcgagtgttt cgctggcggt gagtgtcggc
    20821 gcgagctact cgaagtccga ttcctggtcc tattccgcga cggtgcccgc ggggaagacg
    20881 ttgcggctgc agcagtacaa ggaagcgcgc tcgttcaccg tgcagaagta ccggatcgtc
    20941 ccgccgtgca aggtcaagta cctctggaag aagaacgcgg tcgcaccggt caagagcccc
    21001 agctacctct ggcagctcat cggctgaccc cggttggggt cgatcacaag actcgttcgc
    21061 ccgatcttgt gatcggcccc atggacgtac ggtgaccgtg ccgacacgct gggaggagcg
    21121 tcccgggcaa cggggcccgg acgaaacggg acggtggcca cgatggggaa acttcgcgca
    21181 cggatactga tcgccgggat ggtcgtgctc gcgaccgtgg gtatcacgcc cgccgcgacg
    21241 gccgaggccg gtatcgcgag ccggtggagt gagccggggc cctacgccgt gaccgtcgaa
    21301 gcgctcgaca gcgcccacac cgtgtaccgg ccttcgcggc tggaggagca cccggtgatc
    21361 ttgtggggca atggcaccgg cgcgaatccg aagatctacg acggcctgtt gcggcatctg
    21421 gcctcccacg gcttcgtggt cgcggcggcc gacacgccga acgcgggttc cggtcaggag
    21481 atgctggccg gggccacgac cttgatcgcc gagaactccc ggcccggcag tccgtatcaa
    21541 gggaagatcg acacggcgca catcggcgcc accggccact cccagggcgg tggcggggcg
    21601 atcgccgccg gcgcggactc ccgtgtcacc acgacgatcc cgatcgaacc gggaccgcag
    21661 ggctcggttg cggcgctgaa ggggccttcg ttcttcctgg gcgggcagtt cgacaccatc
    21721 gtcgttcccg ggctgctggt catcccgcgc taccgcgtcg cggaccaggt ccccgcgatc
    21781 tacggcgaac tgggcggagc gacccatttc acgcccgtcg gcgacggagg cgggttccgc
    21841 ggcgcgatca cggcgtggtt ccggttctgg ctttccggtg acgagggggc ccgggccgaa
    21901 ttcttcggcg cttcctgcgg attgtgccgg gacggggcgt ggtccgacgt ccggcgcaac
    21961 gcgaaggcgc tggccgttcc gggagcttga tcgccggatc ttgtcggtgg ccggggttaa
    22021 ggtctgccgc agcagcctga cctggaggga tcccgcgatg accactctcg ccgaccggcc
    22081 gaacaccgcg ctcctggtcg tcgacgtcca gaacggcgtc gtcgacgagg catacgagcg
    22141 tgactccgtg atcgcgaaca tcggcgctct cgtcggcagg gcgcggaggg aaggcgtgcc
    22201 ggtcgtgtgg gtgcggcatt ccgacgaaga actcgtgcga ggcagcgagg agtggcgcat
    22261 cgtcggcgag ctggaccgtg ccgagtccga gcctctcgtc gagaagtcct acggagactc
    22321 gttcgaggac accgatctgg agaaggtgct ggccgagcgc ggtgtcgggc ggctggtggt
    22381 cgccggggcg gagaccgatg cctgcatccg ttcgacactg cacggcgcga tggtccgcgg
    22441 gtacgacgtg acgctggtcg gtgacgcgca tacgaccttc gacaaatcgg cgtggggtgc
    22501 gcccacgccg gagcaggtca tcgcgcacac gaacctgtac tggcggcacc aggtcgcgcc
    22561 ggggcggaag ggaggaacgg tcaagaccga agacgtcgat ttccgcggct gagccgcttc
    22621 accgcgtgcc cggccagcgg gcgatcagca gtccggcgtc gcctgtgaaa ccgctgcggc
    22681 agtgggactt cgccgcatcg agcacccggc ggacgatttc cggcggtacc tgcccggcgc
    22741 tggcgtccag gctggcggcg agcgcgaagc gtgcaccgtc ggcggcgcgc gctcccgtga
    22801 ggccttcggt gtgcagcaca aggagatctc cggcctggag gcgcgaggac ccgatacgcc
    22861 gggagcctcc gtcgccgaac ggcgggcacc gtgcactgtc cactgtggtc ggttcgggtc
    22921 cggtgccgag cacgagcggt ggttccccgc ccgcttcgag atgacgcagg gcgccctgtg
    22981 tgaggtccac ctcggccagg gtgccgcgaa ccgtggtgcc gtcaccgaac ggtgtcgaaa
    23041 gcgctttgtc gacagcgttc tcctggccgc ggaggccatg gccctcgcgg cgggcggatc
    23101 ggtaggccgc gagtgccgcc gagaccgcga ggcccgcggc cccggtgtcc cggcccgcgt
    23161 cgaagatcgc cagccacgcc gtcgtgtcgg acagggcgta gtcgaaggtc actccgcgaa
    23221 cgtcgtaggc gggctcgacg ccgcccgcca ccacgaagtc ggccgtcgcc gccgtcagcg
    23281 ggggcaggtt ctgccagagc agctcggcgg tggggccgcg ccgtctccgg cgccgggtcg
    23341 tgtcgaggcc gtcgccgtag cgcatcgcgg cggcgatgag gtggccggac agcgacgcga
    23401 gccactggca ctgggtgcgc agggtggggt cgtgaaggtc ggcgtccgcg acggcttcga
    23461 tctcgagcac gcccatccgc tcgtcgccgt ccagcagggt ggcccacaac cgcggcccgc
    23521 ccggatcgtc ggtcagcacg gtgccggcgt gccgataggc gcgtccggcg gtactggcct
    23581 cgatgggcag cggcgtccgg tcgggcgcgg actcggtggg aagggggaag agctgccgct
    23641 gctcgtagtc ggcgagatag accgtcagct ccaggtccag cgcccggccg gcggcg
//
