LOCUS       NZ_CP024972            22029 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7829696
            Orig. end                         :: 7851725
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="32"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22029
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12029](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12029)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(13..27)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
     misc_feature    483..494
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    634..643
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(712..728)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     misc_feature    complement(911..925)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.33"
                     /tool="antismash"
     misc_feature    912..925
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.94"
                     /tool="antismash"
     misc_feature    complement(913..926)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.38"
                     /tool="antismash"
     gene            1076..1552
                     /locus_tag="CVV72_RS36200"
                     /old_locus_tag="CVV72_36055"
     CDS             1076..1552
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="CVV72_RS36200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36055"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_219148686.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTRDDYLVEEVRPLIRKYGWMVQTVERGSVQPGFAY
                     TVGLTDAGLPELVVTGLRERRSGQLLNYFAQQVVRSGPPEAGEVLPAAVGWPSFEVVPL
                     SSPPAHLLTAVLLYGDEFRALQLVYEDERGNWPWDREFRGGTGGQPVLGVRGRG"
     gene            complement(1557..2249)
                     /locus_tag="CVV72_RS36205"
                     /old_locus_tag="CVV72_36060"
     CDS             complement(1557..2249)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="CVV72_RS36205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36060"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_125673879.1"
                     /transl_table=11
                     /translation="MSLPDIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDRERVATELEEAVRAMATAADDDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQATYQQVEERVTEHTRIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(2253..3023)
                     /locus_tag="CVV72_RS36210"
                     /old_locus_tag="CVV72_36065"
     CDS             complement(2253..3023)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="CVV72_RS36210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36065"
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_219148688.1"
                     /transl_table=11
                     /translation="MPITPFASPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVVWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVNAARALGVRRVAVAASYPDDVARLFVEFLGAGGVEVV
                     AMGSADIDTAAEVGELSPEAVVELAMSRDHPAADALLVPDTAMRTLSEINTLETRLGKP
                     VLTANQVTVWEGLRLTGKSPLVRTLGALFGRRSN"
     gene            complement(3068..3808)
                     /locus_tag="CVV72_RS36215"
                     /old_locus_tag="CVV72_36070"
     CDS             complement(3068..3808)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="CVV72_RS36215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36070"
                     /product="maleate isomerase"
                     /protein_id="WP_016336992.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLAAATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGATDAVTTSGALAEVLHQLDLHRVSVLTPYDGDLTGKLHDFLAELGVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADAEAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     misc_feature    complement(3794..3796)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3907..4896
                     /locus_tag="CVV72_RS36220"
                     /old_locus_tag="CVV72_36075"
     CDS             3907..4896
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="CVV72_RS36220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36075"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_219148689.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.6e-51, bitscore:
                     173.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASETPVLAVLCGDTRPPDMRAIEDRAVVRYTGEAGLADALSGA
                     DAFFVYDFLSTAVPGAWHAADKLRWLHIASAGVDPVLFPGLQESDVVLTNSRGVFDGAI
                     AEYVLGVVLAFAKDFVRSWDLQRQKQWKHRESERISGRRVLVVGTGPIGRSIARMLRAA
                     GMSVAGVGRRPREGDPDFGDVYASSDLARHLPGADYVVAVAPLTEQTKGMFDAETFAAM
                     KPGARFVNVGRGELVVTSDLIGALRDGPLGGAALDVFDTEPLPSDSPLWTMENVLISPH
                     MSGDFVGWRNTLVEVFADNFRRWRAGEPLRNVVDKQLGYVPSETLRQG"
     misc_feature    4030..4032
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4905..6281
                     /locus_tag="CVV72_RS36225"
                     /old_locus_tag="CVV72_36080"
     CDS             4905..6281
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="CVV72_RS36225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36080"
                     /product="amidase"
                     /protein_id="WP_219148690.1"
                     /transl_table=11
                     /translation="MNDTKLTASELVAAYATGELSPVEATQNALRAIEERDGETNAFCL
                     VDADGALEQAKASEIRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPIDPSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLALPDHRDPAALAPPVSTYREAVRRDVRGLIAAYSPTLGYVDVDPEVAEIVK
                     SAVRSLGDAGLHIEETDPGFTDPKAAFDILWSTGAAKWLDTFPAGSETKVDPGLRKVWE
                     LGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIPAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSRGLPVGLQIVGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(6333..7553)
                     /locus_tag="CVV72_RS36230"
                     /old_locus_tag="CVV72_36085"
     CDS             complement(6333..7553)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033804.1"
                     /locus_tag="CVV72_RS36230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36085"
                     /product="MFS transporter"
                     /protein_id="WP_219148691.1"
                     /transl_table=11
                     /translation="MTSLREPLRHHNFRWLIGGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTEIAATVTQAVIAASVLCGFASI
                     PLLVGLSVVNGAVAAISAPASASLTPLTVPATLLAQANALARLLSNSGRIAGAGLGGIL
                     VTAVGPGWALGGNALLFLGSALSYRCIRLSRRERIPGSRPLAELVEGWHEFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPVVADSTFGRSGWGFALAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILFEAPPLILLGQAPLLPLLLAAMFVSGLAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAAQHFGVSTTLLACAALVVAATALALCSGQVRGLVR
                     KSHAAQP"
     gene            complement(7550..8068)
                     /locus_tag="CVV72_RS36235"
                     /old_locus_tag="CVV72_36090"
     CDS             complement(7550..8068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631259.1"
                     /locus_tag="CVV72_RS36235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36090"
                     /product="transcriptional regulator"
                     /protein_id="WP_219148692.1"
                     /transl_table=11
                     /translation="MSESPGLDGLRVLAHPVRLRILSLLTGVAMSAAEAARELGETQAN
                     VSYHLRRLHEAGLLDVAEEVRIRGGLAKRYRHDPESGSRFTSANPREEQLLIATMAEEL
                     KRRSEFRVPGKPGSTSDAEMWVDRETWKKALEHARELSDLLHSAAKPPRTRGTIPVSAT
                     VSLFEMRRR"
     misc_feature    8102..8115
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            8212..9150
                     /locus_tag="CVV72_RS36240"
                     /old_locus_tag="CVV72_36095"
     CDS             8212..9150
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336987.1"
                     /locus_tag="CVV72_RS36240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36095"
                     /product="aldo/keto reductase"
                     /protein_id="WP_255632374.1"
                     /transl_table=11
                     /translation="MSRIAFGTWQLGGDWGSFDEDAAIAAIHHARELGVNFFDTAQAYG
                     FGKSEAMLGKALREGLKRDRDSLVIATKGGIKPRSERPRDSRREWLAQGIEDSLRFLGV
                     DHIDLYQIHWPDPSTPAEETAGILQEFVDAGKIRHVGVSNYDAAGLAAFDRIRPVETLQ
                     PPYHLLRRDIETDPLPYARENDIGVLVYSPLGSGLLTGSFTPETTFEKSDWRSRSSAFT
                     GETFRHNLAVVDRLKEFAAGKGISVSQLAIAWTLAQPGVHVAIVGARKAANIEASLAAA
                     GIDLTTDDLAEIDRLTADAVLVSGASPEGVA"
     gene            complement(9147..10004)
                     /gene="pqqB"
                     /locus_tag="CVV72_RS36245"
                     /old_locus_tag="CVV72_36100"
     CDS             complement(9147..10004)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="CVV72_RS36245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36100"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_219148694.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCVSDAPPRTQDCVAVSADGEGW
                     YLLNVSPDIRAQILATPPLRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PDAVLGALSEQFPARSIIDGYGGWDWLPSSKVAIDGLRVSVLPVSDKRPKYARSSTEDG
                     PWVVAYRIEDVRTGGVFVYAPCLKSWPDGFDDFTRDAGLVLLDGTFHAPDEMSDAAAAE
                     AGAQLAMGHLPITGSLAKLRPGPRWAYTHLNNTNPVLDPASPEHAAVLNGGASLPLDGT
                     EFKL"
     gene            complement(10001..11083)
                     /gene="pqqE"
                     /locus_tag="CVV72_RS36250"
                     /old_locus_tag="CVV72_36105"
     CDS             complement(10001..11083)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336985.1"
                     /locus_tag="CVV72_RS36250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36105"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_219148695.1"
                     /sec_met_domain="PF04055 (E-value: 1.9e-21, bitscore: 76.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.8e-06, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.6e-08, bitscore: 32.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.1e-10, bitscore:
                     39.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLKTAAPPLGMLAELTHRCPLHCPYCSNPVELIARDGELSTEEW
                     RSVLTQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTESRLDDL
                     VERGIAHIQLSVQGATAERADRLAGARAHDHKLVAAALIKKAGLPLSVNVVLHRQNHDQ
                     LAGIIDLAEEMGADRLELANTQYYGWALRNRDALMPTRRQLDEAEPIVRAATERLRGRM
                     EIIYVVADYYEKYPKPCMYGWGARQLTVAPDGNVLPCPASAAIETLAFDNVRDKPLAWI
                     WYESGSFNAYRGEDWMPDTCGTCERRAIDFGGCRCQAFQLTGDASATDPVCSRSPHRKV
                     VDLILATQAKTDELVMRTAR"
     gene            complement(11074..11346)
                     /gene="pqqD"
                     /locus_tag="CVV72_RS36255"
                     /old_locus_tag="CVV72_36110"
     CDS             complement(11074..11346)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="CVV72_RS36255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36110"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_219148696.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-22, bitscore:
                     78.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-09, bitscore: 36.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVLEPGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAV
                     LSLCDGVVDVAGIASALRERYTGVREEEILDVLSRLGERRIVEWT"
     aSDomain        complement(11083..11343)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CVV72_RS36255_PqqD_RRE.1"
                     /evalue="4.10E-25"
                     /identifier="RREFam006.1"
                     /label="CVV72_RS36255"
                     /locus_tag="CVV72_RS36255"
                     /protein_end="88"
                     /protein_start="1"
                     /score="78.4"
                     /tool="antismash"
                     /translation="TVLEPGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAVL
                     SLCDGVVDVAGIASALRERYTGVREEEILDVLSRLGERRIVE"
     gene            complement(11346..12029)
                     /gene="pqqC"
                     /locus_tag="CVV72_RS36260"
                     /old_locus_tag="CVV72_36115"
     CDS             complement(11346..12029)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631254.1"
                     /locus_tag="CVV72_RS36260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36115"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_219148697.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.6e-85, bitscore:
                     284.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSEFIAALRGLSDRYWGTHPFHVRMHEGDLSARELKIWAANRW
                     YYQCVLPQKDAAIISNCPLPEIRREWLDRIVYHDGTKAGDGGIERWLRLCAAVGLDREE
                     VLDQRHVAPGVRFAVDAYVNFARTKPWLEAVASGLTEMFAGHLMQRRVADMLANYSWIA
                     PEDLAYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAIERA
                     AAKEQ"
     gene            complement(12113..12220)
                     /gene="pqqA"
                     /locus_tag="CVV72_RS36265"
                     /old_locus_tag="CVV72_36120"
     CDS             complement(12113..12220)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="CVV72_RS36265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36120"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_126735666.1"
                     /transl_table=11
                     /translation="MWTLGAEMIEEWTTPDFVEYETPMEVTAYAARMED"
     misc_feature    complement(12209..12211)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12301..12314)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.78"
                     /tool="antismash"
     gene            12515..13498
                     /locus_tag="CVV72_RS36270"
                     /old_locus_tag="CVV72_36125"
     CDS             12515..13498
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="CVV72_RS36270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36125"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_219148698.1"
                     /transl_table=11
                     /translation="MSLRRTLAVTFAAATAVSIAAVPAAAEAPSIQAIRQLASGLNQAW
                     SIDFLPDGTGVFTQKDARTISKIDKAGKVTTVQTVPGVSVTAEAGLLGIAVSPNYATDE
                     TVFIYYTTSSDNRIAKLKLGQAPTPIVTGIPRGSQYHHGGRIRFGPDGYLYAGTGDGQN
                     GANAQNKNSLGGKVLRVTTDGAAAPGNPFNSRVYSYGHRNVQGLTWANGQLYVSDIGAN
                     RLDELNKIEPGKNYGWPTCEGPCNTAGMTNPVKSWPTSSATPSGLAAYKGSLYMASLKG
                     GTYKLDLNGNGGKLWTNLGRTRDATAGPDGQLYTITPGAIYVSDGS"
     misc_feature    12521..12523
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13510..14916)
                     /locus_tag="CVV72_RS36275"
                     /old_locus_tag="CVV72_36130"
     CDS             complement(13510..14916)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336981.1"
                     /locus_tag="CVV72_RS36275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36130"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_219148699.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEGAGPDYLRDIRK
                     SMLESDNMRSVFRRRPARPVNTAGHVAWATDNDLELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPFDLD
                     CPPPWGRRAKPDGARNGKASPSVFSTFGKTVNQLAGIAPAAMKVAREAFQEHTLTLPSQ
                     APKTMFNVPIGGARRFAAQSWSLDRVRRVATAAGVSRNDVVLAMCSGALRDYLMEQNAL
                     PDAPLTAMVPVSLRRKDSGDASGNNIGALLCNLATHLTDPAARLATINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGVSPIPGFVNNTKPPFNLVISNVPGPRKQMYWNGAALDGIY
                     PASVLLDGQALNITLTSNGDNLDFGITGCRRSVPHLQRILTHLDTALAELEHAVSPPRV
                     QSSGRLYPED"
     gene            15012..16025
                     /locus_tag="CVV72_RS36280"
                     /old_locus_tag="CVV72_36135"
     CDS             15012..16025
                     /EC_number="1.8.5.-"
                     /GO_function="GO:0004364 - glutathione transferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="CVV72_RS36280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36135"
                     /product="glutathione S-transferase family protein"
                     /protein_id="WP_219148700.1"
                     /sec_met_domain="GST_C (E-value: 1e-07, bitscore: 30.9,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPQTGEFRRSANHFDARVTADGRDGWPVEAGRYRLVVSRA
                     CPWAGRALVVRRLLGLESALSVAVADPIQDEKSWRFTLDPDDRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSKRLVSNDYPRITLDLSTEWTSLHRPGAPDLYPERLRGEIDD
                     VNVGVHADVNAAVYQAGFATRQAAYEDAYTRLFAMLDVLSERLEKQRYLVGDTITEADI
                     RLFTTLVRFDAVYHGHFKCNRNKLTEMPVLWAYARDLFQTPGFGDTVDFDHIKRHYHAV
                     HEQVNPTRIVPLGPDLSGWTTPHHREQLGGRPFGDGTPPGPPPEDERIGDPHGATS"
     gene            16009..17166
                     /locus_tag="CVV72_RS36285"
                     /old_locus_tag="CVV72_36140"
     CDS             16009..17166
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="CVV72_RS36285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36140"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_219148701.1"
                     /sec_met_domain="DAO (E-value: 4.9e-69, bitscore: 232.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPLPERADVVVIGGGIIGVSCAYRLAAAGVSVLLLERDILGAGS
                     TAKAAGGIRSSFTTRVNIEIGLRGLAEYASFAETYGTEIDFRRDGYLYLVTDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRLSPLIDTEGVVAALWSPDDAKATPDSAVQGYARAA
                     RGQGAVLRTGVEVVGIERDGDEITGVRTGAGFVRTEAVVCAAGAWSGRIGELAGVDLPV
                     RPYRRQVVFTGPVAELPGSVPLTIEMPSAFYFHREGLGLAMSFCDGDGDPGFDTRYQPG
                     EWLPKLAEIAARRVPAVLDAGIRGGWAGLYEVTPDRNQIVGESVHLSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDISGLDVRRFAGDRAVTREHNIV"
     gene            17159..17782
                     /locus_tag="CVV72_RS36290"
                     /old_locus_tag="CVV72_36145"
     CDS             17159..17782
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336978.1"
                     /locus_tag="CVV72_RS36290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36145"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_219148702.1"
                     /transl_table=11
                     /translation="MSEFVEVTTEAELREILPPPLERTANKARPKLHEMDRQWLAESPF
                     VLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFRNVLSNPHVGLIY
                     LIPGRGDTLRINGRARLVREAPFFDDMVVKGNRPKLALVVDIDEIFHHCQKAFMRSKLW
                     SPESWAPGALPSRAAIAKTFERPDDSMADLEAYYAPAAYSAGLY"
     gene            17892..19523
                     /locus_tag="CVV72_RS36295"
                     /old_locus_tag="CVV72_36150"
     CDS             17892..19523
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336977.1"
                     /locus_tag="CVV72_RS36295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36150"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_219148703.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.1e-56, bitscore:
                     187.0, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.1e-27, bitscore:
                     92.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHLADALTALGTEVVFGLPGVHNLPLWEALADTDIRLV
                     GVRHEQTAGYAADGYARATGKLGVALVTTGPGAANTLAAVGEAMASAAPVLIIATDIPS
                     TLRRPGVVRGVLHETSDQQAMFAPVTKAGFTVTSADQVAATLHRAARLALQPQSGPVYL
                     GIPADFLSERTPARRPPRSHARPSEIPDLTEAEALLATADRPLIWAGGGALRAEAGEAI
                     GKLAERLAAPVLTTFGARGLLPVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPQPKKLIAINVDPDDAAKNYPPDITLVGDARVLVEALKVEERAGIAALVGRLA
                     KVSARVRRRIKEEEPQAADLLSTLDEVLPQDAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGASAAGVGRAICVSGDGGFLFGCGDLHTLAQEQLPVTVILVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARAFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRAKMAPPLNTSPRWYRKESP"
     misc_feature    17988..17990
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19520..21580
                     /locus_tag="CVV72_RS36300"
                     /old_locus_tag="CVV72_36155"
     CDS             19520..21580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="CVV72_RS36300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_36155"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_219148705.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGIVAVGKVLTTHDEPARAVEEG
                     LQRTLADAGLDVGDVEQFVHGTTLVTNALIERKGARTALLATAGFRDVLEMRREHRYEL
                     YDLLIELPAPLVPRHLRFDVPERILADGTVHTGLDEEYVARLGRELDARGIDAVAICFL
                     HAFTNPAHERRAAEVLREVAPRLRVALSSEVVPEIREFERMSTTVGCVYVQDLTERYLR
                     DLERRLHEAGVRPSPHIMLSNGGIATVDTAARYPIRILESGPAGGALAASAIGSAAGID
                     DLLAFDMGGTTAKLCLISDGAPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIDALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     LDGAREAIRSKIAGPLGVSVEEAAWGIHTSVNEDMANAARVHAVERGKDPAKLPMFTFG
                     GAGPVHGVGVARALGAPEVVAPPAAGVLSAAGFLTAPLAFDFVRSARSAVLDLSQDQVG
                     ALFGEMEAEGAELLEKSGVDGAAVTHRRIAEMRYAGQGYEIRVPVEGGDWPGSLIDAFT
                     ETYRTLYRRTGPDVAIEVLNWRVVSSGPAPEVTLKLAGTEAEGDARKGSRPAYFPAEGG
                     FADTAVFDRYRLKPGDRVEGPAIVEERESTVVVPPGARCVVREDAGLVVTV"
     misc_feature    21726..21740
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 cgcgggtcgg ggtggagcgg atcatccgct acgccttcga actggcgaag acgcgcacgg
       61 ggcgggtctg ttcggcgacc aagtccaacg gcctcatcca ctccatgcct ttctgggacg
      121 agatcttcgc cgaaatctcc gcggaatacc cggacgtaca cgccgagcag tgccatgtcg
      181 acgcgctcgc cgcccggatg gtgcaggcgc ccgaccggct cgatgtcgtg gtggcttcca
      241 atctgttcgg cgacatcctg agcgacctgg cggcggccgt gacgggcggg ctcgggatgg
      301 cgccttcggg caacatcaat ccgaccggtg agctcccttc catgttcgag gcggtgcacg
      361 gcagcgctcc cgacatcgcc ggtcagggca tcgcgaatcc ggtggcgcag attctggcgg
      421 gagcgatgct gctcgaccat ctcggggaaa ccgttgcggc acaggatgta cgcgcggcgg
      481 tggaaaaggt tctcgaggag ggggccgtgc aaacccccga tctcggcggg aagtccacca
      541 ccgccgaact cgggtccgcg gtggtcgccg ctctatcttg acccatccgc atagcggcgt
      601 gtcaagtccc ggatgtcatg aacggtacat tcatgacttt tgagtgcacg aaggctcctt
      661 ctttgcgtta agcgcagaga aggagccttc gcgcactcaa gggagttaag gctgtagtgg
      721 tgttacgagt agagcatcca cggttcgtgt tcccaatgtc gcattaggga cactcagcgt
      781 ctcgaatgcg acattgggaa cctggctgac tgtcgagtcg cgctccagat gtggcatcgg
      841 ggccgccggc ccgtgaactc ggctttccgc gagggcccag gtggttcagc gcgcgatcat
      901 gctctcggtg aattttctca aacaaggtga aaatgttgcc ctgaaaggag aatctcggcg
      961 cgaaagcggg cattaaagcc cgttcgccgc ctgcacgcca cctcgggccg tgagtttttg
     1021 tcggtgcccc ggtgcacagt gccggtcatc ggattcgacg actggaggag caccgatgtg
     1081 ctggcattgc gacaaccccg ggaagacccg cgacgactac ctcgtcgagg aggtccgtcc
     1141 gctgatccgg aagtacggct ggatggtgca gacggtcgag cgcggaagtg tccaacccgg
     1201 tttcgcgtac acggtcgggc tcaccgatgc cgggctgccg gagctcgtcg tcaccggcct
     1261 gagagagcga agatccgggc aactgctgaa ttatttcgcc cagcaggtgg tgcggtccgg
     1321 accgccggag gcgggtgagg tgctgcccgc cgcggtcgga tggccgtcgt tcgaggtcgt
     1381 cccgctcagt tcgccgccgg cgcacctgct caccgccgtt ctcctgtacg gcgacgaatt
     1441 ccgcgcgctg caactggtct acgaggacga gcgcggcaat tggccgtggg acagggagtt
     1501 ccgcggcggg acgggcggcc agccggtgct gggggtgcgg ggccgtggct gaatccctaa
     1561 ggcaccgcgg gagcttcgcc ttcccgcagg ctggttcccg gggccagccg ctggacggcg
     1621 tcttccatat gggcttccag cagcgacagt gcggtctctt cgtcgccggc ccgcagggct
     1681 tcgatgatcc tggtgtgttc ggtgacccgt tcctcgacct gctggtaggt cgcctgcagt
     1741 gcggtgaggc acatccgcgt ctcgatcagc aaggtcctgg ccatgcgcac gagccgcttg
     1801 ctgcccgaag cggcgatcaa cgcttcgtgg aaacggaggt ccgcccagga gagcgccgtg
     1861 gggtcgtcgt cgtccgcggc ggtggccatg gcgcgcacgg cctcttcgag ttcggtggcg
     1921 acccgttccc tgtccccgcg cagtgcccgc agcattgcgg cgcgctcgat ggccgaacgc
     1981 gccgagtaga tgtcgtagac gtcgccgggc tcgaggtcga tcacgaacag gccgcggtgg
     2041 cgctcgctgc gcaggagtcc ttcggaaacg aggtgctgca tcgcctcgcg cagcggaccc
     2101 cgcgaaacct ggaaccggga ggcgagatcc gtttcaccga gctgggtgcc gggagggagg
     2161 gcgccggtca tgatcgcgtc ccgcaactgc cgtgcgatga tcccggcggt cgactcccgg
     2221 ctgaccggct cgatatccgg caaggacatg gctcagttgc tccttctccc gaacagcgcg
     2281 cccagtgtgc ggacgagcgg cgacttcccg gtgagccgca aaccttccca gacggtgacc
     2341 tggttggcgg tcagcaccgg cttgccgagc ctggtttcga gtgtgttgat ctcgctgagc
     2401 gtccgcatgg cggtgtcggg gacgagcagc gcgtcggcgg cggggtggtc ccggctcatc
     2461 gcgagctcga cgacggcttc cggactgagt tcgccgacct cggcggcggt gtcgatgtcc
     2521 gcgctgccca tcgcgaccac ttcgactccg cccgcgccga ggaactcgac gaacagccgg
     2581 gcgacgtcgt ccgggtaact ggcggcgacc gcgacccgcc ggacaccgag cgcccgtgcg
     2641 gcgttgacga aggcgaagga cgtactcgac gccgggacac cggcgacggc ggccagccgg
     2701 tcggcctggt cacgggcgcc ttcccagccg tagacgaagc tgccgctggt gcacgcccac
     2761 accaccgcgt cgggttcgtg tttggccagg agcgcggcgc cgtcggcgag ccggctttcg
     2821 ctaccgaggt ccaagagctc cggcacggcg tgcagatcgg ttccgtagat gtgctcgacc
     2881 ggcagcttga tcccggccat gtccccgccg aggagctgtt ccgcgagcgg gtagtcgtct
     2941 tcggccgcgt gatcggggta gatgaacccg atggtggtcg tctcggacgg cggctcgggc
     3001 gaggcgaacg gcgtgatggg cacggaacct ccggagggca gattgtcgac aatcgtaggc
     3061 gaagaggtca gtcgacctcc cggagccact tgccgggccc gacgatcggc aggttcatcc
     3121 gccggaggca ggcccacatg gtgagctgat tcgcggtgag gaccggtttg ccgagcgcgc
     3181 tttcgagtgg ctcgatcaga tcgtaggtgg ggaggttggt gcagctgacg aagatggctt
     3241 cggcgtcggc gtggtcggcg gcgaggatgc gctcggcgat ggtccggtaa ctgaccttcc
     3301 agatgccgcc gcccaggccg agatggtcgc tggagacggt gcggacgccg agttcggcca
     3361 ggaagtcgtg cagcttcccg gtcaggtcgc cgtcgtaggg cgtcagcacc gagacccggt
     3421 ggaggtcgag ctggtgcagg acctccgcca gcgcgccgga cgtggtgacg gcgtccgtcg
     3481 cgcccgcgtc gcagatcgcc ttggtcagtg agcgttcgta gtccacaccg ttgacgaaac
     3541 tgccggaggt gcacagatag gcgacgactt cgggctcgac gtggagcacg tcccgcgtgg
     3601 cggcggcgag atgcctgctg tcgctgacga gctgggccat ctccatgctg acgggcacgg
     3661 gctcgtacgg cgtccgcgcc agatggaggg aaacctccat gggcacccag cgccacagct
     3721 cgcgttccag ggccaggtcg aagggggcga tcacgccgat accgcgctgc gccaacgggc
     3781 cttcgaactc cagtaagtcg aaatccaagt ctcagcctcc ggaaacgtct gctgtcacag
     3841 tccggtgctc cgggggtcgt tcctcggatt gttgacaatc atacgagcca cttttacggt
     3901 gtcaacgtga tcgcctcgga gacccctgtg ctggcggtgc tctgcggaga cacgcgccca
     3961 ccggacatgc gcgctatcga agaccgagcg gtggttcgtt acaccggcga ggccgggttg
     4021 gccgacgcgt tatccggagc cgacgcgttc ttcgtctacg acttcctttc gaccgccgtc
     4081 ccgggcgcct ggcacgcggc cgacaaactg cgctggctgc acatcgccag cgcgggggtc
     4141 gaccccgtcc tgttcccggg gctgcaggag agcgacgtcg tgctcaccaa ctcccgcggg
     4201 gtgttcgacg gggcgatagc cgagtacgtc ctcggagtcg tcctcgcgtt cgccaaggat
     4261 ttcgtccgtt cgtgggacct gcagcgacag aagcagtgga agcaccggga gagtgaacgg
     4321 atctccggcc gccgggtcct cgtggtcggc accgggccga tcggccggtc gatcgcgcgg
     4381 atgctgcggg cggccgggat gtccgtggct ggcgtcgggc gccgtcctcg tgagggcgac
     4441 cccgacttcg gagacgtgta cgcgtcctcg gacctcgccc gtcatcttcc cggggcggac
     4501 tacgtcgtcg cggtcgcgcc actgaccgag cagacgaagg gcatgttcga cgccgagacc
     4561 ttcgccgcga tgaagcccgg cgcgcggttc gtcaacgtcg gccgaggcga gctggtcgtc
     4621 acctcggatc tgatcggcgc actgcgggac gggccgctcg gcggcgcggc gctcgacgtc
     4681 ttcgacaccg agccgctccc ctccgatagt cctttgtgga ctatggagaa cgtgctgatc
     4741 tcgccgcata tgtcgggtga cttcgtcggc tggcgtaata ctctggtaga ggtgttcgcg
     4801 gacaacttcc gtcgctggcg cgcgggggag ccactgcgca acgtcgtgga caagcagctc
     4861 gggtacgtgc cgtcggagac gcttcgccaa ggttaggggc cggattgaac gacaccaagt
     4921 tgaccgcgag cgagctcgtc gccgcgtacg ccaccggaga gctgtcgccg gtcgaggcca
     4981 ctcagaacgc cttgcgggcc atcgaagaac gcgacggcga gaccaacgct ttctgcctgg
     5041 tcgacgccga cggcgcgctc gaacaggcga aagcgtccga gatccgctgg cgcgacggca
     5101 atccgatcgg ctggctcgac ggcgtcccgg cctcgatcaa ggacatgttc ctgacccagg
     5161 gctggccgac gctgcgtggt tcgcggtgca tcgacccaga ccagccgtgg gacgtcgaca
     5221 gcccggtcac cgcgcggctg cgtgagaacg gcttggtgct gctgggaaag accacgacgc
     5281 cggaactggc gtggaagggc gtcaccgaca acaccctgac cgggatcacc cgcaacccga
     5341 tcgacccgtc gacgacggcg ggagggtcca gcgggggcag cgccgcggcc gtcgcggcgg
     5401 ggatgggcga actctccgtc ggcaccgatg gcggcggctc aatccggatc ccggcttcgt
     5461 tctgcggaat cgtcgggctc aaaccgacgc acggccggat cccgctgttc ccggcgagtc
     5521 cgttcggccc gctctcgcac gccggcccga tggcgcgttc ggtcgacgac acggcgctgc
     5581 tcctcgacgt cctcgccctg ccggaccacc gtgacccggc cgcgctcgcg ccaccggtct
     5641 cgacctatcg cgaggccgtc cgccgggacg tgcgcgggct gatcgccgcc tactcgccga
     5701 cgctcggcta cgtcgacgtc gacccggagg tggcggagat cgtcaagtcg gcggtccggt
     5761 cgctgggcga cgcgggcctg cacatcgaag agaccgatcc cggtttcacc gacccgaaag
     5821 cggccttcga catcctgtgg tcgacggggg cggccaagtg gctggacacc ttccccgccg
     5881 gttcggagac gaaggtcgat cccgggctgc ggaaggtgtg ggaactcggc aagaccttct
     5941 cggcgagcga ctacctcggc gccaacgccg agcgggccgc gctgggcatc ctgatgggcg
     6001 agttccacac gcgctacgac gtgctgatca cgccgactct ccccattccc gccttcgagg
     6061 cagggcacga ggtgccgccg ggcagcgggc tgagcggctg gccggactgg acgccgttca
     6121 cctatccgtt caacatgacc cagcagcccg ccatcagtgt tccggcgggc cgcacctcac
     6181 gcggtctccc ggtcggcttg cagatcgtcg gcccgcggca ctccgacgat ctggtcctcg
     6241 cggtcgcgaa gctcctcgag gaggttcgtc cctggccgtg acctgcggaa agggagcaag
     6301 ggacctttgc taccactttc gggggcgggg gatcagggct gcgcggcgtg ggacttccgg
     6361 acgagcccgc gcacttggcc gctgcacagc gcgagagcgg tggccgctac gaccagcgcg
     6421 gcgcacgcga gcagtgtcgt gctgaccccg aagtgctgcg cggcgggtcc ggccgccatc
     6481 tgtccgagcg gcagggcgat gaaggaaccg agcatgtcgt aggagtagac gcgcgcgagt
     6541 ttgtcctcgg gcacgttctc ctgcagcgag acgtcccacg cgaccacgaa ctgctcgatc
     6601 gccagcccgg agacgaacat ggccgccagc agcagcggca gcaagggagc ctggccgagg
     6661 aggatcagcg gcggcgcttc gaagaggatc accgcgacgc cgacgaacag tgcgcggcgc
     6721 ggctgccatc gggccacgag gatcccgccg acgagcgagc cgatcgtctg cgcggcgagg
     6781 gcgaatcccc agccggagcg tccgaaagtg ctgtcggcga cgacggggcc gagcaccgcg
     6841 atcccgcccg cgatgacggc gttcaccacc atgaactgca cgaccacgac ccacacccac
     6901 gtgcgcgacc ggaactcgtg ccagccttcg acgagttccg ccagcgggcg gctgccgggg
     6961 atccgttccc ggcggctgag gcggatgcac cggtaggaca gggcggagcc gaggaacagc
     7021 agcgcgttcc cgccgagcgc ccagccgggg ccgaccgcgg tgaccaggat gccgccgagc
     7081 ccggcgccgg cgatccggcc ggagttcgac aacagcctcg ccagcgcgtt ggcctgcgcg
     7141 aggagggtgg cgggcaccgt cagcggggtg agcgacgccg acgcgggggc ggagatcgcg
     7201 gccaccgcgc cgttgaccac gctcaggccg accagcagcg ggatcgacgc gaatccgcaa
     7261 aggacactcg ccgcgatgac cgcctgggtc accgtggcgg cgatttcggt gccttgcagg
     7321 atcaccgacc gcggtagccg gtccgccagc accccgccga acagcagcag gaccacgctc
     7381 gccacggatc gcgcgccgac gacgatgccg atgtcgacgg ccgaaccggt caggtcgatc
     7441 accgcgaacg cgagcgcgag cggggcgacg gcgttgccga actccccgaa cgtgcggccg
     7501 ccgatcagcc agcggaagtt gtgatggcgc agtggttcgc gcagggacgt caccgtcgcc
     7561 tcatttcgaa cagcgagacc gtcgcgctga ccgggatcgt gccccgggtg cggggcggtt
     7621 tcgcggcgga gtgcaggagg tcgctcagtt cgcgagcgtg ttcgagcgcc ttcttccagg
     7681 tctcgcggtc gacccacatc tccgcgtcgc tcgtcgaccc cggcttgccg ggaacgcgga
     7741 attcgctgcg gcgcttgagt tcttcggcca tcgtcgcgat gagaagctgt tcttcccgcg
     7801 gattcgccga cgtgaaccgc gatccggact ccggatcgtg ccggtagcgt ttcgccaggc
     7861 cgccccggat ccggacctcc tcggcgacgt ccagcaggcc ggcttcgtgc aaccgtcgca
     7921 ggtgatagct gacattcgct tgtgtctcac cgagttcgcg cgcggcttcg gccgcgctca
     7981 tcgcgacacc ggtcaaaagc gacagaatgc gcagccgtac gggatgggcg aggacacgca
     8041 acccgtcgag gccgggggac tcggacatga gccgagtatc ggctgccggg acgccaaccg
     8101 tcaaacagtt atttgggggt ttcattggcc gggagatccg gtgcggtgat ccgatgtctg
     8161 tgctctgctg gagggatgcg tacgacgaca ttgggcagga gcggcctcga ggtgtcgagg
     8221 atcgctttcg gcacttggca actcggcggg gactggggtt cgttcgacga ggacgcggcg
     8281 atcgcggcga tccatcacgc ccgcgaactc ggcgtgaact tcttcgacac cgcacaggcc
     8341 tacgggttcg ggaagtccga agcgatgctg gggaaggcgc tgcgtgaagg actcaagcgc
     8401 gaccgcgaca gcctcgtcat cgccacgaag ggcggcatca agccgcgttc cgaacggccg
     8461 cgcgactcgc ggcgcgagtg gctggcccag ggcatcgagg acagcctccg ctttctcggc
     8521 gtcgaccaca tcgacctcta ccagatccac tggcctgacc ccagcactcc ggccgaggag
     8581 acggcgggga tccttcagga gttcgtcgac gcggggaaga tccggcacgt cggtgtctcg
     8641 aactacgacg ccgcggggct ggccgccttc gacaggatcc ggcccgtgga aaccctgcag
     8701 ccgccgtatc acctgctccg ccgcgacatc gaaaccgacc ctctcccgta cgcgcgcgag
     8761 aacgacatcg gcgtgctcgt gtacagcccg ctgggcagcg gactgctgac cggatccttc
     8821 acgccggaga cgacgttcga gaagagcgac tggcggtcac gatcgtcggc gttcaccggc
     8881 gagaccttcc ggcacaatct cgccgtcgtc gaccggctca aggaattcgc ggcgggcaag
     8941 ggaatctccg tcagtcaact ggcgatcgcg tggacgctcg cccagccggg tgtgcacgtc
     9001 gcgatcgtgg gcgcgcggaa ggcggccaac atcgaggcca gtctcgccgc cgccggcatc
     9061 gacctgacca cggacgatct cgcggagatc gatcggctca ccgccgacgc cgttctcgtg
     9121 tcgggcgcga gccccgaagg tgtcgcctaa agcttgaatt cggtaccgtc caagggaagc
     9181 gaggcgccgc cgttcagtac ggcggcgtgt tcgggcgacg cgggatcgag caccgggttc
     9241 gtgttgttca ggtgggtgta cgcccaccga gggccgggcc ggagcttcgc caggctgccg
     9301 gtgatcggaa gatgacccat agccagctga gcgccggctt cggccgcggc ggcgtccgac
     9361 atctcatccg gcgcgtggaa ggtcccgtcc agcagtacca gtccggcatc gcgggtgaag
     9421 tcgtcgaatc cgtccggcca gctcttcaaa caaggcgcgt aaacgaaaac gccgccggtc
     9481 cggacgtctt cgatccggta cgccaccacc catggaccgt cctcagtgga cgaacgggcg
     9541 tacttcggcc gcttgtcgct cacgggaagc acgctcaccc gcagcccgtc gatggcgacc
     9601 ttcgacgacg gcagccagtc ccagccgccg tatccgtcga tgatcgaccg cgcggggaac
     9661 tgctcggaca aggcgccgag cacggcgtcc ggtgcccaca cgggcaggcc gcccgcttcc
     9721 cgcagaagaa gcaggccgag tgaatggtcg agttcggcgt cggtcagcag cactccgcgc
     9781 agcgggatct ccctcggccc cggcccggcg cgcagcggtg gggtggcgag gatctgcgcg
     9841 cggatgtccg gtgacacgtt gagcaggtac cagccctcgc cgtccgcgct caccgccacg
     9901 cagtcctgtg tccgcggcgg cgcgtccgac acgcacaggg cgcaggcgca gttccactgc
     9961 gggaaaccgc cgcccgccgc ggtgccgagc aggatcaccc tcatcgtgcc gtccgcatca
    10021 cgagttcgtc cgttttcgcc tgtgtggcga ggatgaggtc gacgaccttt cgatgcgggg
    10081 aacgtgagca caccggatcc gtcgccgacg cgtcaccggt gagctggaac gcctggcagc
    10141 ggcagccgcc gaagtcgatc gcgcgccgtt cgcaggtgcc gcaggtgtcc ggcatccagt
    10201 cctcgccgcg gtaggcgttg aaggaaccgg attcgtacca gatccacgcc agcggcttgt
    10261 cccgcacgtt gtcgaatgcc agcgtctcga tcgccgccga ggcgggacac ggcagcacgt
    10321 tcccgtccgg cgccacggtc agttgccgcg cgccccagcc gtacatgcac ggtttcgggt
    10381 acttctcgta gtagtcggcg acgacgtaga tgatctccat gcggccacga aggcgttcgg
    10441 tggccgcgcg cacgatcggc tcggcctcgt cgagctggcg ccgggtcggc atcagggcgt
    10501 cacggttgcg cagggcccag ccgtagtact gcgtgttggc cagttcgagc cggtccgcgc
    10561 ccatttcctc ggccaggtcg atgatcccgg cgagctgatc gtggttctgc cggtgcagga
    10621 cgacgttcac cgaaagcggc agtccggcct tcttgatcag tgcggcggcg accagcttat
    10681 ggtcgtgtgc ccgcgctccg gcgagccggt ccgcgcgttc ggcggtcgcg ccctggacgg
    10741 acagctggat atgcgcgatg ccgcgctcga cgagatcgtc caatctggac tccgtcagtc
    10801 cgagcccgga cgtcaccaga ttgacgtagc accccagttt cgtggcgtgt tcgaccagga
    10861 tgggcagatc cggcctggcg agcggttcgc cgccggacat gtgcacctgg agcacgccga
    10921 gttcccgcgc ctgggtgagc acggaccgcc attcctctgt ggacagttcg ccgtcacggg
    10981 cgatcagctc gaccggattc gagcaatacg ggcaatgcag cgggcagcga tgggtcagct
    11041 cggccagcat gcccagtggc ggcgccgcgg ttttcaggtc cattcgacga tccgccgttc
    11101 tcccagccgg gacaggacgt ccaggatctc ttcctcgcgc acaccggtgt agcgttcgcg
    11161 caacgccgaa gcgattcccg ccacgtccac gacgccgtcg cagagggaaa gcacggccgc
    11221 ggcggtcgga ttcgggacga gcacaccctc ggggaacagg aggacgtgcg tttccctggt
    11281 ctggtcgtaa ctcagccgga ctccgcgccg cagccgcggc accgagcccg gttcgaggac
    11341 ggtcatcact gctccttggc cgcggcgcgc tcgatggcgt cgagcatcga ccagagcacg
    11401 tcggtcttga acgacagcgc ggcgatcgcc ttctcctgct gctcgcgggt gacggcgtgc
    11461 cgcacgacga tgtcgagcgt ccccttgccc tcaccggaca ccttgtcgat gcgattcgtg
    11521 aaataggcca gatcctccgg cgcgatccac gaatagttcg ccagcatgtc ggcgactcgc
    11581 cgctgcatga gatggccggc gaacatttcg gtcagccccg aggcgaccgc ttcgagccag
    11641 ggtttcgtgc gggcgaaatt cacgtaggcg tcgacggcga accggacgcc gggggcgacg
    11701 tgccgctgat cgagaacctc ttcgcggtcg agcccgaccg cggcgcacaa ccggagccat
    11761 cgctcgattc cgccgtctcc ggccttcgtc ccgtcgtggt agacgatgcg gtcgagccat
    11821 tcccggcgga tctccggcaa cgggcagttg ctgatgatcg ccgcgtcctt ctgcgggaga
    11881 acgcactggt agtaccagcg attcgcggcc cagatcttca gctcgcgcgc ggacaggtcg
    11941 ccttcgtgca tccgcacgtg gaacgggtgg gtgccccaat agcggtccga aagcccgcgc
    12001 aacgccgcga tgaactccga cgacgacatg agggacaccg tgcagcctcc gggtgttcgc
    12061 tgatcgggac ggcggcggtg gtgggggacg gcccccacca ccggatgcgg attcagtcct
    12121 ccatgcgggc cgcgtaggcg gtgacctcca tgggggtctc gtactcgacg aagtcggggg
    12181 tggtccattc ctcgatcatt tccgctccta acgtccacat gggatcgaac agggccgagc
    12241 caccgtcacc ctagaagcgc gtcgccgatt ctgaccagac gtaaggaccg acttccggcg
    12301 gtattttgta aagtttccta cctatggccg atcgaccggg gcgggccgtc acgctcggcg
    12361 cacacaacgg ttaacggccg gtgggtccga tagcccgtcc agtggtgtcc gtttcgttcc
    12421 gttgtgtgtt tctatccaac tcgacgggtg caccccgacc acccgcctac cgccgccatc
    12481 cgagctccag gggtgtagct gaaggaggcg tcccatgtcc ttacgtcgta ctctcgccgt
    12541 cacgttcgcc gcggcgacgg ccgtgtcgat cgcggccgtc ccggcggccg ccgaagcgcc
    12601 gtcgatccag gcgatcagac agctcgcgag cggcctcaac caagcctggt cgatcgattt
    12661 cctgcccgac ggcaccggtg tcttcacgca gaaggacgcc aggacgatca gcaagatcga
    12721 caaggcgggc aaggtcacca cggtccagac cgtccccggg gtgagcgtca ccgcggaggc
    12781 cggtctgctc ggcatcgccg tctcgccgaa ttacgccacc gacgagacgg tcttcatcta
    12841 ctacacgacc agttccgaca accgcatcgc caagctgaag ctgggccagg caccgacgcc
    12901 gatcgtcacc ggcatcccgc gcggttcgca gtaccaccac ggcgggcgga tcaggttcgg
    12961 cccggacggc tacctctacg cgggtaccgg cgacggccag aacggcgcca acgcgcagaa
    13021 caagaactcg ctcggcggca aggtcctgcg ggtcaccacc gacggcgcgg ccgcgcccgg
    13081 caacccgttc aacagccgcg tctactccta cggccaccgc aacgtccagg gcctgacctg
    13141 ggcgaacggc cagctgtacg tttccgacat cggcgccaac cggctcgacg agctgaacaa
    13201 gatcgagccc ggcaagaact acggctggcc gacctgcgag ggcccgtgca acacggccgg
    13261 gatgaccaac ccggtcaagt cctggccgac gtcctcggcg acgccgagcg ggctcgcggc
    13321 ctacaagggc tcgctgtaca tggcttcgct gaagggcggc acgtacaagc tcgacctgaa
    13381 cggcaacggc ggcaagctct ggaccaacct cggccgcact cgcgacgcga ccgccggccc
    13441 ggacggccag ctgtacacga tcacccctgg cgccatctac gtctccgacg gcagctgacc
    13501 ccggcgcgtt cagtcctctg gatacagccg tccagaggac tggacgcggg gcggggagac
    13561 cgcgtgttcg agttcggcga gcgcggtgtc caggtgggtc aggatgcgct gcagatgcgg
    13621 cacgctccgg cggcagccgg tgatgccgaa gtccaggttg tccccgttgc tggtcagcgt
    13681 gatgttcagc gcctgcccgt ccagcagtac cgacgccggg tagatgccgt cgagcgccgc
    13741 gccgttccag tacatctgct tgcgcggccc cggcacgttg gagatcacca ggttgaacgg
    13801 cggtttcgtg ttgttcacga aacccgggat cggggacacg ccgagctggg cgacgttgat
    13861 gcccgacagc agcagcgtct gcagcggggt cagctccgag aagagcttct tgccgttccg
    13921 catggacgcg ttgatcgtgg ccagccgggc ggccggatcg gtcagatggg tggcgaggtt
    13981 gcacagcagc gcgccgatgt tgttccccga cgcgtcccca ctgtccttgc gccgcaagga
    14041 aaccgggacc atcgcggtca ggggcgcgtc ggggagcgcg ttctgttcca tcaggtagtc
    14101 ccgcagcgcg cccgagcaca tcgcgaggac gacgtcgttg cgcgacaccc cggcggcggt
    14161 cgccaccctg cgcacgcggt ccagcgacca cgactgcgcg gcgaaccggc gggccccgcc
    14221 gatcggaacg ttgaacatcg tcttcggcgc ctgtgacggc agcgtgagcg tgtgctcctg
    14281 gaacgcctcc cgtgccacct tcatcgcggc gggcgcgatg ccggcgagct ggttcaccgt
    14341 cttgccgaag gtgctgaaca ccgagggcga cgccttgccg ttgcgggcgc cgtccggttt
    14401 ggcgcggcgc ccccacggcg gcgggcagtc gaggtcgaac gggtcgtccg acagcgtgcc
    14461 ctgaaggtgc cgcagtgccg agacgccgtc catcagcgcg tggtggatct tgctgtagat
    14521 cgcgaaccgg ccgtcctgca ggccctcgac caggtggatc tcccacagcg gacggtgccg
    14581 gtcgagcagg gtgctgtgcc agcggccggt cagctccagc agctcgcgga tccggccggg
    14641 ctggggcagc gccgaatgcc ggaagtggta gtcgagttcg agatcgttgt cggtcgccca
    14701 cgcgacgtgc cccgcggtgt tgaccggccg ggcgggacgg cgccggaaca ccgagcgcat
    14761 gttgtcggac tcgagcatgc tcttgcggat gtcacgcaga tagtcggggc ccgcgccctc
    14821 gggtttcttg aacagctgca gtccgccgac gtgcatcgga tgttcgcgcg tttccacgag
    14881 aaggaacatc gaatcggtca cgggcatgaa cggcatcgtc ggaccacctt ccgcgcggcg
    14941 gcgtgcgagc acgccgggtg ccagagtcta cgcacaccga aaccaccttc tcacgcttta
    15001 gggtggctca catgacgatc ccgaccgatc cgcagacggg tgagttccgt cggtccgcca
    15061 accatttcga cgcgcgtgtc accgccgacg gccgcgacgg ctggccggtg gaggcgggga
    15121 gataccggct ggtggtcagc cgggcctgtc cctgggccgg ccgcgccctg gtcgtccggc
    15181 ggctgctcgg cctcgagtcc gcgctgagcg tggccgtggc cgacccgatc caggacgaga
    15241 agagctggcg gttcaccctc gatcccgatg accgggatcc ggtgctcggc atcaagtacc
    15301 tggccgaggc ctatcacgcg gccgatccgc actacatggg cgggatcagc gttccggcca
    15361 ttgtggacat tccgagcaaa cggctggtga gtaacgacta tccgcggatc accctagatc
    15421 tgtccaccga atggaccagc ctccaccggc ctggcgcgcc cgacctctac ccagagcgac
    15481 ttcgcggcga gatcgacgac gtcaacgtgg gcgtccacgc ggatgtcaac gccgccgtct
    15541 accaagccgg gttcgcgacc agacaggccg cgtacgagga cgcttacacc cggctcttcg
    15601 ccatgctgga cgtgctttcc gagcggctgg aaaagcagcg ctacctcgtc ggtgacacga
    15661 tcaccgaagc ggacatccgg ttgttcacca cgctcgtccg cttcgacgcc gtctaccacg
    15721 ggcacttcaa gtgcaaccgg aacaaactga ccgaaatgcc ggtgctgtgg gcctacgccc
    15781 gcgacctctt ccaaacgccg ggcttcggtg acaccgtcga cttcgaccac atcaagcggc
    15841 actaccacgc ggtgcacgag caggtgaacc cgacgcggat cgtccctttg ggaccggacc
    15901 tgtccggctg gacgacgccg caccaccggg agcagctggg cgggcgcccg ttcggcgacg
    15961 gcacgccgcc gggaccgccg cccgaggacg aacggatcgg ggacccgcat ggagccactt
    16021 cctgaacgcg ccgacgtcgt cgtgatcggc ggcggcatca tcggggtcag ctgcgcatac
    16081 cggctggccg ccgccggggt ctcggtcctg ctgctcgaac gcgacatcct gggcgcgggc
    16141 tcgacggcga aggcggcggg cgggatccgg tcctcgttca ccacccgggt caacatcgag
    16201 atcgggctgc gcgggctggc cgagtacgcc tccttcgccg agacgtacgg gacggagatc
    16261 gacttccgcc gcgacggcta cctgtacctg gtcaccgacc ccgcggacct gcccgaattc
    16321 gaacgctgcg cagaactgca gaactcgtac ggcgttcgca gccgtctcgt cgagcccgcc
    16381 gaagcgcggc ggctctcccc gctgatcgac accgagggcg tcgtcgcggc gctgtggtcg
    16441 ccggacgacg ccaaggcgac cccggactcc gccgtccagg gttacgcgcg ggcggcccgc
    16501 gggcaaggtg cggtgctcag gaccggtgtc gaggtggtcg ggatcgaacg cgacggcgac
    16561 gagatcaccg gcgtccggac cggtgccggt ttcgtgcgga cggaagcggt ggtctgcgcg
    16621 gcgggcgcgt ggtcgggccg gatcggggaa ctcgccggtg tcgaccttcc ggtgcggccg
    16681 taccggcggc aggtcgtgtt caccggcccg gtcgcggagc tgcccggatc cgtgccgctg
    16741 accatcgaga tgccgtccgc cttctacttc catcgcgagg gtctcggcct ggcgatgtcc
    16801 ttctgcgacg gtgacggcga ccccggcttc gacacccgct atcagccggg cgagtggctg
    16861 ccgaaactcg ccgagatcgc cgcgcgccgg gtgcccgcgg tgctcgacgc ggggatccgc
    16921 ggcggctggg ccgggctgta cgaggtcacc cccgaccgca accagatcgt gggggaaagc
    16981 gtccacctgt cgcggttctt ctacgccacc ggcttttccg ggcacgggtt ccagatgggc
    17041 ccggcggtgg gggagctcgt gcgggacctc tacctggggc gggtcccggc catcgacatc
    17101 agcgggctcg acgtccgccg gttcgccggc gaccgggccg tgacgaggga gcacaacatt
    17161 gtctgagttc gtcgaagtca ccaccgaagc cgagctgcgc gagatcctgc cgccgccgct
    17221 ggaacggacc gcgaacaagg cgcgcccgaa gctgcacgag atggaccgcc agtggctcgc
    17281 ggagtcaccg ttcgtgctga tcgcgacgtc ggcggccgac ggcacctgcg acgtctcgcc
    17341 gaagggcgac ccggccgggt tcaccctggt actggacgac acgcggatcg ccatcccgga
    17401 gcgccccggc aaccggcgcg ccgacgggtt ccgcaacgtg ctgtcgaatc cgcacgtcgg
    17461 gctgatctac ctgatccccg gccgcggcga cacgctgcgg atcaacggcc gcgcgcggct
    17521 cgtgcgggag gcaccgttct tcgacgacat ggtcgtgaag ggcaaccggc cgaagctcgc
    17581 gctggtcgtc gacatcgacg agatcttcca ccactgccag aaggcgttca tgcggtcgaa
    17641 gctgtggtcg ccggagagct gggcgcccgg cgcgctgccg tcgcgggcgg cgatcgcgaa
    17701 gaccttcgaa cggccggacg acagcatggc cgacctggag gcttactacg cccctgccgc
    17761 ctactcggcc ggtctgtact gaagccagtt gcgcgtgaag gcccccttcc ctcggctcag
    17821 ccgagggaag ggggccttca cgcgcagtga ttggttgctg gatcgttgaa cgatctggca
    17881 ctatcggcgg ggtgcctgca cccaccggag cccagcatct cgccgacgcg ctgaccgctc
    17941 tggggaccga agtcgtcttc ggtctccccg gggtgcacaa cctgccgtta tgggaggcgc
    18001 tggccgatac ggacatccgg ctcgtcgggg tccggcacga gcagacggcg gggtacgccg
    18061 ccgacgggta cgcccgcgcg acggggaagc tcggcgtcgc gctggtgacc acggggcccg
    18121 gagcggcgaa cacgctcgcc gccgtcggcg aggccatggc gtcggcggcg ccggtgctga
    18181 tcatcgccac cgacatcccg tccacgctgc ggcggccggg cgtggtccgc ggcgtgctgc
    18241 acgagacgtc ggaccagcag gcgatgttcg cgccggtcac caaggcaggc ttcaccgtca
    18301 cgagcgccga ccaggtcgcc gccaccctcc accgcgcggc ccggctcgcg ctccagccgc
    18361 agagcgggcc ggtgtacctc ggcatccccg ccgacttcct gtcggagcgg acacccgcgc
    18421 gccgcccgcc gcggtcgcac gcccggccgt ccgagatccc ggacctcacc gaggccgagg
    18481 cgctcctggc caccgccgac cggccgctga tctgggcggg cggtggcgcg ctgcgcgccg
    18541 aggcgggtga ggcgatcggg aagctcgccg aacggctggc cgcgccggtg ctcaccacgt
    18601 tcggcgctcg cgggctcctg ccggtcgatc atccctgtct cgccccgaat ccggtgcacg
    18661 cgcccgaggt cggcgcgctg tgggacgagg ccgacgtcgt cctcgcgatc ggcaccgact
    18721 tcgacgggct gatgacccag aactggctga tgccgcagcc gaagaagctc atcgcgatca
    18781 acgtcgaccc ggacgacgcg gccaagaact acccgccgga catcaccctg gtcggcgacg
    18841 cccgggtgct cgtcgaggcg ctgaaagtcg aggaacgggc gggtatcgcg gcactcgtcg
    18901 gcaggctcgc caaggtctcc gcccgggtcc ggcggcggat caaggaggag gaaccgcagg
    18961 cggcggatct gctgtccact ttggacgagg tgctgccgca ggacgcggtc gtggtcgcgg
    19021 acatgtgcgt ggccgggtac tggatcggcg ggttccatcg cgtccgcgcg ccccgcaagc
    19081 tcgcgtaccc gatgggctgg ggcaccctcg gctacggttt ccccgccgcg ctcggcgcga
    19141 gcgccgcggg cgtcggccgc gcgatctgcg tcagcggtga cggcggtttc ctgttcggct
    19201 gcggcgatct gcacacgctc gcgcaggaac agctgccggt cacggtgatc ctcgtcgacg
    19261 acggcggcta cgggatgctc cgctacgacc aggatcgcgc ggggctgcca cgccgggggg
    19321 tggactggga cagtcctgat ttcgtcggcc tggcgagggc tttcggcgta cacgcggacc
    19381 gtgtttccgg attcgggcgc gcgttccggc ggctgctcgg cgaattcgtc gagtccgacg
    19441 agcccaacgt gctggtcgtg cgcgcgaaga tggctccgcc gctcaacacc tcgccgcgct
    19501 ggtaccgcaa ggaatccccg tgaccgggct ccgggtcggc gtggacatcg gcggcacgtt
    19561 caccgatctc tgcgtactcg acgagaccgg tatcgtggcg gtcggcaagg tgctgaccac
    19621 gcacgacgaa cccgcccggg cggtcgaaga aggcctccag aggacactcg cggacgccgg
    19681 gctggacgtg ggcgacgtcg agcagttcgt gcacggtacg acactggtca cgaacgcgct
    19741 gatcgaacgc aagggagcac gcaccgccct gctggcgacg gccggtttcc gcgacgtgct
    19801 ggagatgcgg cgcgagcacc ggtacgaact gtacgatctg ctcatcgaat tgccggcgcc
    19861 actggtgcca cggcacctgc ggttcgacgt ccctgaacgg atcctcgccg acggtaccgt
    19921 ccacacagga ctggacgagg agtacgtcgc gcggctcggc cgggagctcg acgcccgggg
    19981 gatcgacgcg gtggcgatct gtttcctgca cgccttcacg aatcccgcgc acgaaaggcg
    20041 ggcggccgag gtgctgcggg aggtcgcgcc ccggttgcgg gtcgcgctct ccagcgaggt
    20101 cgtccccgag atccgcgagt tcgaacgcat gtcgaccacg gtcggctgcg tctacgtcca
    20161 ggacctcacc gaacgttacc tgcgtgacct ggaaagacgc ctgcacgagg ccggggtgcg
    20221 gccgtcaccg cacatcatgc tgtccaacgg cgggatcgcg accgtcgaca ccgccgcgcg
    20281 ctacccgatc cgcatcctcg aatccgggcc ggccggcggg gcgctggccg cgtccgcgat
    20341 cgggtccgcg gcggggatcg acgatctgct ggccttcgac atgggcggca cgacggcgaa
    20401 attgtgcctg atctccgatg gcgcgccgct ggtgacgcac gagttcgaag tggaccggaa
    20461 gtaccggctg ctgccgggat ccgggctgcc ggtcaaggta ccggtcacgg acatgatcga
    20521 gatcggcgtc ggcggcggtt cgatcgcgcg gatcgacgcg ctcgggctgc tcaccgtcgg
    20581 tccggattcg gcggggtccg agcccggccc ggtctgttac ggccgaggtg gcaccgagcc
    20641 gaccgtgacg gacgccgacc tcgtgctcgg ctatctggat ccggggtatt tcctcggggg
    20701 cggaatgact ctggatctcg acggcgcgcg cgaggcgatc cgctcgaaga tcgccgggcc
    20761 gctcggcgtc agcgtcgaag aggccgcttg gggcatccac accagtgtca acgaggacat
    20821 ggccaacgcc gcccgggtcc acgccgtcga gcggggcaaa gatccggcga agctgccgat
    20881 gttcactttc ggcggcgccg gtccggtgca cggcgtcggg gtggcgcggg cgctcggcgc
    20941 gcccgaggtg gtcgcgccgc cggccgccgg ggtgctcagc gcggcgggat tcctcaccgc
    21001 gccactggct ttcgacttcg tgcgttcggc gcgctccgcg gtgctcgacc tttcccagga
    21061 ccaggtcggc gccctgttcg gagagatgga ggccgagggc gcggaactgc tggagaagtc
    21121 cggcgtggac ggtgcggcgg tgacgcaccg ccggatcgcc gagatgcggt acgccgggca
    21181 gggctacgag atccgggtgc cggtcgaggg cggggactgg ccgggttcgc tgatcgacgc
    21241 gttcaccgag acctatcgga cgctgtatcg gcggaccggg ccggatgtcg cgatcgaggt
    21301 gctgaactgg cgtgtcgtct ccagcggccc ggcgcccgag gtcacgctga aactcgcggg
    21361 caccgaggcc gagggcgacg cgcgcaaagg gagccgtccc gcgtacttcc ccgccgaagg
    21421 tggctttgcc gacacggcgg tgttcgacag gtaccggctc aagccgggtg atcgcgtcga
    21481 gggtccggcc atcgtggagg agcgggagtc cactgtggtc gttccaccgg gggcgcgctg
    21541 tgtcgtccgc gaagacgccg gcctggtggt gacggtatga gcgtcgaccc gatcctggtg
    21601 ggggtgctgg gaaaccggct gcactccatc ctggccgaac agcagaacgc gctcgtcaac
    21661 acggcgttct cgtccgtggt gcgggaatcg ctcgacctcg cctgcgcggt gttcgactcc
    21721 cgcggtgaga tgatcggcca gtccgtcggc gggacgcccg gccacatcaa cgcgatggcc
    21781 accgggatgc accatttcgt cgccgcgtac ccgccggagg cgctggaacc cggcgacgtc
    21841 ctgctcacca acgacccctg gcagacggcc gggcagatca acgacatcac cgtcgcgacg
    21901 ccggtgttcc tgcggggacg gctggtcgcg tggttcgcct cctgctgcca cgccccggac
    21961 atcggcgggc gcctggtctc cgccgaggcc agtgaggtct tcgaggaggg cctgcgcctg
    22021 ccgatcatg
//
